A convenient intraperitoneal drug delivery auxiliary device for murine animals

Abstract

The present invention provides a convenient murine intraperitoneal drug administration auxiliary device, comprising a fixed cylinder, an end cover and an anti-retraction device. One end face of the fixed cylinder is open and the other end face is movably connected to the end cover. The anti-retraction device is arranged in the fixed cylinder. An operation window is arranged on one side of the anti-retraction device, and a plurality of plug-in slots are arranged in parallel on the other side. Slide slots are symmetrically installed in the operation window, and a function board is slidably connected in the slide. An injection window is arranged on the function board, and a joint limit plate is inserted in the plug-in slot. Restraining windows are arranged on the front and rear sides between the anti-retraction device and the operation window, and the windows are sealed with rubber. The structural design of the present invention is scientific and reasonable, and it is highly practical. The operation is simple and labor-saving. The stable restraint of animals can be completed with one hand. It can be used for murine animals of different sizes, has high safety, and can be promoted for use.

Description

Technical Field

[0001] The invention relates to a drug delivery device, in particular to a convenient intraperitoneal drug delivery auxiliary device for murine animals. Background Art

[0002] Animal experiments are a major component of scientific research. As one of the means of scientific research, it directly determines the level of scientific research. Animal anesthesia is the first step in animal experiments and the key to determining the success of the experiment. Traditional rat capture and restraint can be roughly divided into four steps: 1. Open the mouse cage, pinch the mouse tail with your right hand and lift it up, and place it on a rough surface or the mouse cage cover. 2. Gently pull the mouse tail back. When the rat crawls forward, use the thumb and index finger of your left hand to form a "V" shape to press the back of the rat's neck to fix it and prevent it from turning back. 3. The thumb and index finger can push forward and pinch the rat's neck skin and ears. 4. After pinching, turn over your left hand, pinch the rat's tail with your right hand to straighten the rat's body position, and place it in the palm of your left hand so that the rat's body is in a straight line.

[0003] Traditional restraint injection methods mostly require two people to operate, which requires high operating skills and high quality requirements for operators. It is easy to be bitten during the grasping process, and it is easy to break free during intraperitoneal administration after restraint, which makes the failure of administration more serious and can cause the needle to injure surrounding tissues. In view of the above drawbacks, it is necessary to design an efficient and convenient animal intraperitoneal drug delivery device that can be operated by one person. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a convenient intraperitoneal drug administration auxiliary device for murines in view of the deficiencies of the above-mentioned prior art. The device has a scientific and reasonable structural design, is easy to operate, and has strong practicality. It can quickly and stably restrain the experimental subjects, and is convenient and accurate for intraperitoneal injection drug administration to murines. It can be promoted and used in the field of animal experimental research.

[0005] In order to solve the above technical problems, the technical solution adopted by the present invention is: a portable murine intraperitoneal drug administration auxiliary device, characterized in that it includes a fixed tube, an end cover and an anti-retraction device, one end face of the fixed tube is open, and the other end face of the fixed tube is movably connected to the end cover, an anti-retraction device is arranged in the fixed tube, and operation windows and plug-in plate slots are respectively arranged on both sides of the anti-retraction device on the fixed tube, and the plug-in plate slots are arranged in parallel and equidistantly, and a corresponding safety hole is arranged at the bottom end of the plug-in plate slot, and a head limit plate is movably inserted in the plug-in plate slot, and a function plate is slidably arranged in the operation window, and an injection window is arranged on the function plate. Two manual restraining windows are symmetrically arranged on the outer wall of the fixed tube between the anti-retraction device and the operation window, and the restraining windows are sealed by rubber.

[0006] Preferably, the anti-retreat device is composed of multiple anti-retreat plates, each of which is a fan-shaped plate bent into an arc, one end of which is fixedly connected to the inner wall of the fixed tube, and the other ends of the multiple anti-retreat plates are aggregated to form a restraining ring for the head and forelimbs of rodents to pass through.

[0007] Preferably, the anti-recoil plate is made of a material with certain elasticity, plasticity and hardness, such as semi-rigid PVC material or vulcanized rubber, etc. As long as the anti-recoil plate can be deformed as the rodents drill in and can return to their original position in time, the arc bending direction of the anti-recoil plate is the same as the direction of travel of the rodents in the fixed cylinder. The fixed cylinder is black and dark inside the barrel. According to the habit of rodents to burrow in secret, rats will habitually enter the fixed cylinder and then pull their tails outward. Driven by instinct, rodents will crawl forward, and their heads will pass through the restraining ring to drive the anti-recoil plate to tilt. The rats will stop under the obstruction of the head limit plate. Since the anti-recoil plate is bent into an arc, the restraining ring is stuck in the rat's chest. At this time, the operator makes the index finger and middle finger of one hand "V"-shaped and stuck in the manual restraining window and exerts force in opposite directions to assist in fixing the rat's body. At the same time, the palm is located at the open end face of the fixed cylinder against the animal's buttocks, forming a triple anti-recoil effect, that is, achieving the whole body restraint of the rodents. The abdomen of the rat is exposed at the operation window, and the drug injection operation for the rat is completed through the injection window.

[0008] Preferably, the operation window is rectangular, a slide groove is fixedly connected in parallel in the operation window, a slide bar is slidably arranged in the slide groove, and two slide bars are fixedly connected to both sides of the function board. An adjustment head for pushing the function board to slide is arranged on the function board. Pushing the adjustment head makes the function board slide so that the injection window is aligned with a suitable injection position.

[0009] Preferably, the end cap is threadedly connected to one end of the fixing cylinder.

[0010] Preferably, the head limit plate is perpendicular to the central axis of the fixing tube when inserted into the plugging plate slot, and a lifting handle is fixedly provided on the head limit plate.

[0011] Preferably, a plurality of safety holes are provided on the outer side wall of the fixing tube, and the safety holes are located directly below the plug-in plate slot on the side wall of the fixing tube. When the lifting handle on the head limit plate breaks, the head limit plate is ejected through the safety holes.

[0012] Preferably, an air hole is provided on the outer side wall of the fixing tube, and the air hole is located on the outer side wall of the fixing tube between the anti-retraction device and the plug-in plate slot.

[0013] Compared with the prior art, the present invention has the following advantages:

[0014] 1. The structural design of the present invention is scientific and reasonable, the operation is simple, the binding is safe and reliable, and it is convenient for researchers to inject drugs into the abdomen of experimental animals. The injection drug administration efficiency is high, it is suitable for single-person operation, and can be promoted for use.

[0015] 2. The present invention secures the chest, abdomen and buttocks of experimental animals by means of an anti-retraction device, a manual securing window and a palm-closed blocking of the open end of the fixing tube. The all-round securing completely secures the experimental animals during the drug administration process to avoid struggling due to discomfort and the needle injuring surrounding organs and tissues, while completely avoiding the risk of being bitten by experimental animals.

[0016] 3. The present invention exposes the abdominal position of the experimental animal through the operating window, and aligns the injection window with the specific injection position through the sliding function plate, so as to facilitate the injection and administration of murine animals of different body sizes. The present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the three-dimensional structure from the first viewing angle of the present invention.

[0018] Figure 2 It is a schematic diagram of the stereoscopic structure from a second viewing angle of the present invention.

[0019] Figure 3 It is a schematic diagram of the connection structure between the functional board and the slide groove in the present invention.

[0020] Figure 4 It is a structural schematic diagram of the head limiting plate in the present invention.

[0021] Figure 5 It is a schematic diagram of the main structure of the anti-retreat device in the present invention.

[0022] Figure 6 It is a schematic diagram of the side structure of the anti-recoil plate in the present invention.

[0023] Description of reference numerals:

[0024] 1—fixed cylinder; 2—end cover; 3—operating window;

[0025] 4—chute; 5—functional board; 6—anti-return device;

[0026] 7—Anti-recoil plate; 8—Securing ring; 9—Plug plate slot;

[0027] 10—injection window; 11—adjustment head; 12—air vent;

[0028] 13—Head limit plate; 14—Lifting handle; 15—Sliding bar;

[0029] 16—manual securing window; 17—safety hole. DETAILED DESCRIPTION

[0030] like Figures 1 to 6 As shown, the present invention includes a fixed cylinder 1, an end cover 2 and an anti-retreat device 6, the left end face of the fixed cylinder 1 is open, the right end face of the fixed cylinder 1 is movably connected to the end cover 2, the anti-retreat device 6 is arranged in the fixed cylinder 1 perpendicular to the central axis of the fixed cylinder 1, an operation window 3 is arranged on the left side of the anti-retreat device 6 on the fixed cylinder 1, a plug-in plate slot 9 is arranged on the right side of the anti-retreat device 6 on the fixed cylinder 1, a safety hole 17 is arranged on the side wall of the fixed cylinder 1 directly below the plug-in plate slot 9, five corresponding plug-in plate slots 9 and safety holes 17 are arranged in parallel at equal distances, and two manual securing windows 16 are symmetrically arranged on the outer wall of the fixed cylinder 1 between the anti-retreat device 6 and the operation window 3. A head limiting plate 13 is movably inserted into the plug-in plate slot 9. After the head limiting plate 13 is inserted into the plug-in plate slot 9, it is parallel to the anti-retreat device. A function plate 5 is slidably arranged in the operation window 3. An injection window 10 is provided on the function plate 5. A black rubber film is provided on the manual restraining window 16. The restraining window allows the fingers to pinch and fit the rat's body to completely fix it, and the rat can be quickly restored after letting go.

[0031] In this embodiment, Figure 1 As shown, two manual securing windows 16 are symmetrically arranged on the upper and lower sides of the operating window 3 .

[0032] In this embodiment, the anti-recoil device 6 is composed of eight anti-recoil plates 7, which are fan-shaped plates bent into an arc. The anti-recoil plate 7 is fan-shaped when viewed from the front and arc-shaped when viewed from the side. The wide end of the anti-recoil plate 7 is fixedly connected to the inner wall of the fixed cylinder 1, and the opposite narrow ends of the eight anti-recoil plates 7 are aggregated to form a retaining ring 8 for the head of the rodent to pass through. The aggregated narrow ends of the anti-recoil plates 7 are provided with arc-shaped protective heads, which are made of silicone.

[0033] In this embodiment, the anti-recoil plate 7 is made of vulcanized rubber material, which has certain elasticity, plasticity and hardness, can maintain the overall shape of the anti-recoil device 6 and can be deformed and reset as the rat drills in and out, and the arc bending direction of the anti-recoil plate 7 is the same as the moving direction in the fixed tube 1. That is, the anti-recoil plate 7 is inclined and bent to the right side of the fixed tube 1.

[0034] In this embodiment, the fixed cylinder 1 is black, and the inside of the barrel is dark. According to the habit of rats to burrow in the dark, rats will habitually enter the fixed cylinder 1. When the rat enters the fixed cylinder 1 from the left end, the rat will crawl forward by pulling the rat tail. The head passes through the retaining ring 8 to drive the anti-retraction plate 7 to tilt to the right. The rat stays under the obstruction of the head limit plate 13. The retaining ring 8 is stuck on the rat's chest. The abdomen, chest and buttocks of the rat are well secured by the fingers stuck in the manual retaining window 16, the retaining ring 8 and the palm at the open end face of the left end of the fixed cylinder 1. The abdomen of the rat is exposed at the operation window 3, and the injection operation of the rat is completed through the injection window 10. Multiple plug-in slots 9 can plug the head limit plate 13 into different plug-in slots 9 according to the different body sizes of the rat, and limit the position of the rat's head to ensure that the retaining ring 8 can be accurately stuck on the rat's chest.

[0035] In this embodiment, the functional plate 5 is a curved plate.

[0036] In this embodiment, the operation window 3 is rectangular, and the upper and lower inner walls of the operation window 3 are fixedly connected to the slide groove 4. A slide bar 15 is slidably arranged in the slide groove 4, and two slide bars 15 are fixedly connected to the upper and lower sides of the function board 5. The function board 5 is provided with an adjustment head 11 for pushing the function board 5 to slide. Pushing the adjustment head 11 makes the function board 5 slide so that the injection window 10 is aligned with a suitable injection position.

[0037] In this embodiment, the end cover 2 is threadedly connected to one end of the fixing tube 1 .

[0038] In this embodiment, the diameter of the head limit plate 13 is the same as the diameter of the fixed tube 1, and a lifting handle 14 is fixedly provided on the head limit plate 13. When the lifting handle 14 breaks, a thin wooden stick or a needle is used to push the head limit plate 13 out through the safety hole 17.

[0039] In this embodiment, an air vent 12 is provided on the outer wall of the fixing tube 1. The air vent 12 is located on the outer wall of the fixing tube 1 between the anti-retreat device 6 and the plug-in plate slot 9 to ensure that the restrained rat has sufficient air in the device.

[0040] When in use, observe the body length of the experimental subject and insert the head limiting plate 13 at a suitable position in the plug slot 9, and aim the left end opening of the device at the head of the rat. The rat will enter the fixing tube 1 under the instinctive tendency of liking to drill holes in the dark. When the rat drills into the fixing tube 1, gently pull the tail of the rat backwards. The rat will instinctively move in the opposite direction. When it is blocked by the head limiting plate 13, the front paws of the rat just pass the anti-return device 6, and the anti-return plate 7 blocks the position of the rat's chest. At this time, the operator places the index finger and middle finger of one hand in a "V" shape at the manual restraining window 16, exerts force in opposite directions to pinch the abdominal cavity of the rat, and the palm of the hand presses against the open end of the fixing tube to press against The rat's buttocks form a triple anti-retreat effect, that is, the whole body of the rat is restrained, so that it cannot turn back or retreat. Keeping the fixed gesture, flip the fixed cylinder 1 180° to make the rat's abdomen face up and expose it from the operation window 3, turn the adjustment head 11 to align the injection window 10 with the injection position, and use the other hand to inject the drug into the rat's peritoneum through the injection window 10. After the drug is administered, flip the fixed cylinder 1 again, unscrew the end cover 2 and pull out the head limit plate 13, release the fingers at the manual restraint window 16, and the rat will drill out of the fixed cylinder 1 from the side of the end cover 2, thus completing the intraperitoneal drug injection operation for the rat.

[0041] The above is only a preferred embodiment of the present invention and does not limit the present invention in any way. Any simple modification, change and equivalent change made to the above embodiment according to the technical essence of the invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A convenient intraperitoneal drug delivery device for murines, characterized in that: The invention comprises a fixed cylinder (1), an end cover (2) and an anti-retraction device (6), wherein one end face of the fixed cylinder (1) is open, and the other end face of the fixed cylinder (1) is movably connected to the end cover (2); the anti-retraction device (6) is arranged in the fixed cylinder (1); an operation window (3) and a plug-in plate slot (9) are respectively arranged on both sides of the anti-retraction device (6) on the fixed cylinder (1); a plurality of plug-in plate slots (9) are arranged in parallel and at equal distances; a joint limit plate (13) is movably inserted in the plug-in plate slot (9); a function plate (5) is slidably arranged in the operation window (3); an injection window (10) is arranged on the function plate (5); and two manual securing windows (16) are symmetrically arranged at a position between the anti-retraction device (6) and the operation window (3) on the outer wall of the fixed cylinder (1); The anti-recoil device (6) is composed of a plurality of anti-recoil plates (7) spliced ​​together, wherein the anti-recoil plate (7) is a fan-shaped plate bent into an arc, one end of the anti-recoil plate (7) is fixedly connected to the inner wall of the fixed cylinder (1), and the other ends of the plurality of anti-recoil plates (7) are aggregated to form a retaining ring (8) for the head and forelimbs of the rodent to pass through; The anti-recoil plate (7) is made of a material with elastic plasticity and hardness, and the arc-shaped bending direction of the anti-recoil plate (7) is the same as the moving direction of the rodent in the fixed cylinder (1); The operating window (3) is rectangular, a slide groove (4) is fixedly connected in parallel with the operating window (3), a slide bar (15) is slidably arranged in the slide groove (4), and the two slide bars (15) are fixedly connected to two sides of the function board (5); The functional plate (5) is provided with an adjusting head (11) for pushing the functional plate (5) to slide; When the head limit plate (13) is inserted into the plug-in plate slot (9), it is perpendicular to the central axis of the fixed tube (1); a lifting handle (14) is fixedly provided on the head limit plate (13); and a plurality of safety holes (17) are provided on the fixed tube (1) at the bottom position directly below the plug-in plate slot (9).

2. A convenient murine intraperitoneal drug delivery auxiliary device according to claim 1, characterized in that: An air vent (12) is provided on the outer wall of the fixed cylinder (1), and the air vent (12) is located on the outer wall of the fixed cylinder (1) between the anti-retraction device (6) and the plug-in plate slot (9).

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