Saliva detection device and detection method thereof

Abstract

The present invention relates to a saliva detection device and a detection method thereof, which belongs to the field of medical devices and solves the problem of time-consuming saliva detection in the prior art. The present invention includes a liquid introduction mechanism, an incubator, a test tube rack, a flip mechanism, a rotating boss and a rotating sub-boss, the rotating boss is installed at the bottom of the device, the rotating sub-boss is rotatably installed on the rotating boss, the test tube rack is arranged on the rotating sub-boss, the rotating sub-boss drives the test tube rack to rotate itself, and aligns with different infusion channels to introduce different liquids; then the test tube rack is rotated to the position of the incubator or the flip mechanism by the rotating boss, and after flipping by the flip mechanism, the mixed liquid is poured on the microplate, and the microplate is taken out for detection. The saliva detection device of the present invention integrates the collection, processing, storage and use of saliva, reduces the operation process of saliva detection, and realizes the automated processing of saliva detection.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical instruments, and in particular to a saliva detection device and a detection method thereof. Background Art

[0002] Saliva is a complex mixture that contains not only various proteins, but also DNA, RNA, fatty acids, and various microorganisms. Saliva collection is safe and convenient, non-invasive, without the risk of blood-borne disease transmission, simple process, low price, and has the advantage of real-time sampling. Saliva can be used for early diagnosis and treatment of oral and dental diseases.

[0003] However, most dental clinics are not equipped with saliva testing devices. In addition to the non-stimulating method of saliva flowing out of the mouth naturally, the existing saliva biological sample collection method sometimes requires stimulation to increase the secretion of the salivary glands in order to obtain more samples. The above method has the following problems: it is not easy to collect saliva directly, the cleanliness of the medical environment is difficult to maintain, and it is easy to contaminate the test paper card.

[0004] Although the existing simple detection device has a fast detection procedure, the data that can be obtained is extremely limited. The precision detection process often requires the use of PCR technology or mass spectrometry, which is complicated to operate, time-consuming and consumable. The saliva cannot be stored after collection, which requires multiple saliva collection during the detection process. Before the saliva test, liquids such as buffer solution need to be added to the saliva. The process of post-processing the collected saliva is cumbersome and inconvenient to operate. Therefore, it is necessary to provide a saliva detection device to post-process and store the collected saliva at a constant temperature. Summary of the invention

[0005] In view of the above analysis, the present invention aims to provide a saliva testing device and a saliva testing method to solve the problems that the existing dental clinics are not equipped with saliva testing devices, saliva testing is time-consuming and labor-intensive, costly and time-consuming, and the collected saliva cannot be stored.

[0006] The purpose of the present invention is mainly achieved through the following technical solutions:

[0007] A saliva detection device comprises: a test tube rack, a liquid introduction mechanism, a rotating boss and a rotating sub-boss; the rotating boss is rotatably mounted on the bottom of the saliva detection device; the rotating sub-boss is rotatably mounted on the rotating boss; the test tube rack is placed on the rotating sub-boss; and a test tube for collecting liquid is installed in the test tube rack.

[0008] Furthermore, the rotating sub-boss is eccentrically arranged on the rotating boss.

[0009] Furthermore, the rotating boss and the rotating sub-boss are driven to rotate along their own axes by the first motor and the second motor respectively; when the rotating boss rotates, the test tube rack can be transferred, and when the rotating sub-boss rotates, the test tube rack can be rotated along its own axis.

[0010] Furthermore, there are four rotating sub-bosses, which are evenly distributed circumferentially on the rotating boss.

[0011] Furthermore, the liquid introduction mechanism includes: a liquid pump and a liquid infusion pipeline.

[0012] Furthermore, it also includes: an insulated box; the insulated box can keep the liquid in the test tube warm.

[0013] Furthermore, the test tube rack is provided with a plurality of test tube mounting holes; the test tubes are arranged in the test tube mounting holes.

[0014] Furthermore, an elastic rubber pad is provided on the test tube mounting hole.

[0015] Furthermore, the infusion pipeline includes: a first infusion pipeline, a second infusion pipeline, a third infusion pipeline and a fourth infusion pipeline; the outlet ends of the first infusion pipeline, the second infusion pipeline, the third infusion pipeline and the fourth infusion pipeline are downwardly oriented and symmetrically distributed in the circumferential direction.

[0016] Furthermore, in order to achieve uniform mixing of the liquid in the test tube and pouring it onto the microplate, the saliva detection device of the present invention is also provided with a flipping mechanism.

[0017] Furthermore, the flipping mechanism includes: a driving mechanism, a transmission mechanism and a test tube rack slot. The flipping mechanism can flip the test tube rack. The test tube rack slot can be engaged with the test tube rack. The driving mechanism can drive the test tube rack slot to flip through the transmission mechanism. The microplate is detachably mounted on the test tube rack slot; after the test tube rack and the test tube are flipped, the microplate is located below the test tube rack.

[0018] Furthermore, the transmission mechanism comprises: a transmission gear and a spur rack; the transmission gear and the spur rack are meshed. The transmission gear is fixedly connected to the test tube rack slot; the spur rack is fixedly connected to the housing of the saliva detection device; the driving mechanism can drive the transmission gear to rotate itself while rolling up and down relative to the spur rack.

[0019] Furthermore, the flipping mechanism also includes: a mounting bracket, a slider, a connecting plate and a slide rail fixedly arranged on the mounting bracket; the driving mechanism can drive the slider to move up and down; the slider and the slide rail are slidably matched; the slide rail is parallel to the spur rack; one end of the connecting plate is fixedly connected to the slider, and the other end is rotationally connected to the transmission gear; the spur rack is fixedly connected to the mounting bracket.

[0020] Furthermore, the driving mechanism is a linear motor, a cylinder or a hydraulic cylinder.

[0021] A saliva detection method of a saliva detection device comprises the following steps:

[0022] Step S1: Turn on the liquid pump and introduce saliva and buffer solution into the test tube on the test tube rack through the infusion pipe;

[0023] Step S2: the first motor drives the rotating boss to rotate, and transfers the test tube rack to the inside of the incubator for insulated heat, waiting for the use of the saliva sample;

[0024] Step S3: When the saliva sample needs to be tested, the liquid in the test tube is poured into the microplate;

[0025] Step S4: Take out the microplate and perform saliva testing on the saliva sample.

[0026] Furthermore, in step S1, when liquid is introduced into the test tube through the infusion pipe, saliva, buffer solution and dye solution are introduced through different infusion pipes respectively.

[0027] Furthermore, in step S1, the second motor drives the rotating sub-boss to rotate, and the rotating sub-boss drives the test tube rack to rotate, so that the test tubes are aligned with different infusion pipes, and the saliva, buffer solution and dye solution are introduced into the test tubes.

[0028] Furthermore, in step S3, the first motor is driven to drive the rotating boss to rotate, and the test tube rack is transferred to the flipping mechanism, and the test tube rack can be flipped by the flipping mechanism.

[0029] The technical solution of the present invention can achieve at least one of the following effects:

[0030] 1. The saliva testing device of the present invention has an incubator, which can insulate and preserve the saliva when the saliva testing cannot be performed in time.

[0031] 2. The saliva testing device of the present invention can realize the position transfer of the test tube rack by rotating the rotating boss, and then perform liquid injection, heat preservation or flipping operations. The operation is simple and is conducive to the rapid implementation of saliva testing in dental clinics.

[0032] 3. In the saliva testing device of the present invention, a test tube rack groove is provided on the flipping mechanism to hold the test tube rack, and the driving mechanism drives the transmission gear to mesh and roll along the spur rack. When the transmission gear rolls along the spur rack, it can drive the test tube rack to flip, and the liquid in the test tube is poured onto the microplate. The microplate can be taken out for testing. The flipping mechanism of the present invention realizes the automatic pouring of the mixed liquid in the test tube, which is convenient for the subsequent testing process.

[0033] 4. The saliva detection device of the present invention injects saliva, buffer solution and other liquids into the test tube through multiple infusion pipes, and drives the test tube rack to rotate through the rotating sub-boss, so that the test tube can be aligned with different infusion pipes to achieve the addition of different liquids, thereby realizing the automated addition of saliva and its buffer solution.

[0034] 5. The saliva detection device of the present invention can realize the left and right shaking of the test tube rack slot and the test tube rack by driving the transmission gear to reciprocate up and down along the spur rack through the driving mechanism, and has the function of mixing the liquid in the test tube evenly, which is convenient for subsequent detection and saves manpower. The flipping mechanism has the functions of pouring the liquid in the test tube and shaking the test tube. The rotation angle of the transmission gear is determined according to different functional requirements. When the transmission gear rotates slightly (small rotation angle), the test tube shaking function can be realized. When it rotates greatly (large rotation angle), the test tube rack and the test tube can be flipped to pour the liquid into the microplate.

[0035] In the present invention, the above-mentioned technical solutions can also be combined with each other to achieve more preferred combination solutions. Other features and advantages of the present invention will be described in the subsequent description, and some advantages can become obvious from the description, or can be understood by practicing the present invention. The purpose and other advantages of the present invention can be realized and obtained through the contents particularly pointed out in the embodiments of the description and the drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] The drawings are only for the purpose of illustrating specific embodiments and are not to be considered limiting of the present invention. Like reference symbols denote like components throughout the drawings.

[0037] Figure 1 is an external view of the saliva detection device of the present invention;

[0038] Figure 2 It is a left side view of the saliva detection device of the present invention;

[0039] Figure 3 It is a right side view of the saliva detection device of the present invention;

[0040] Figure 4 The internal structure of the saliva detection device of the present invention is shown in FIG. Figure 1 ;

[0041] Figure 5 The internal structure of the saliva detection device of the present invention is shown in FIG. Figure 2 ;

[0042] Figure 6 A top view of the internal structure of the saliva detection device of the present invention;

[0043] Figure 7 A bottom view of the saliva detection device of the present invention;

[0044] Figure 8 It is a schematic diagram of the structure of the insulation box;

[0045] Fig. 9 It is a schematic diagram of the heating structure of the heat preservation box;

[0046] Fig.10 Schematic diagram of the test tube rack structure;

[0047] Fig.11 It is a cross-sectional view of a test tube rack;

[0048] Fig.12 It is a schematic diagram of the flip mechanism structure;

[0049] Fig.13 A rotating boss;

[0050] Fig.14 The rotary boss;

[0051] Fig.15 This is a cross-sectional view of the rotating boss.

[0052] Reference numerals:

[0053] 1-housing; 11-liquid pump; 12-display; 13-control key; 14-inlet and outlet; 111-first infusion pipeline; 112-second infusion pipeline; 113-third infusion pipeline; 114-fourth infusion pipeline;

[0054] 2-heating box; 21-arc channel; 22-heating resistance wire; 23-temperature sensor;

[0055] 3-test tube rack; 31-first support plate; 32-second support plate; 33-third support plate; 34-middle shaft; 35-test tube mounting hole; 36-test tube; 37-concave hole;

[0056] 4-flipping mechanism; 41-mounting bracket; 411-slide rail; 412-spur rack; 413-U-shaped groove; 42-sliding block; 43-connecting plate; 44-driving mechanism; 45-transmission gear; 46-flipping bracket; 47-test tube rack slot; 48-microplate;

[0057] 5-rotating boss; 51-sub-boss mounting hole;

[0058] 6-rotating sub-boss; 61-boss disc; 62-sub-boss connecting shaft; 63-protrusion;

[0059] 7- first driving gear;

[0060] 8- Second drive gear. DETAILED DESCRIPTION

[0061] The preferred embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings, wherein the accompanying drawings constitute a part of the present invention and are used together with the embodiments of the present invention to illustrate the principles of the present invention, but are not used to limit the scope of the present invention.

[0062] A specific embodiment of the present invention discloses a saliva detection device, such as Figure 1-Figure 15 As shown, it includes: a liquid introduction mechanism, an incubator 2, a test tube rack 3, a flipping mechanism 4 and a transmission mechanism; wherein the test tube rack 3 is placed above the transmission mechanism and is moved by the transmission mechanism, and the transmission mechanism can move the test tube rack 3 from the bottom of the liquid introduction mechanism to the incubator 2 for insulation or to the flipping mechanism 4 for flipping. The test tube 36 is installed on the test tube rack 3, and the liquid introduction mechanism is used to introduce saliva and buffer into the test tube 36; the incubator 2 has an insulation function and can keep the liquid in the test tube 36 warm; the flipping mechanism 4 includes a microplate 48 and a test tube rack slot 47, the test tube rack slot is used to fix the test tube rack 3, and the flipping mechanism 4 can flip the test tube rack 3, pour the liquid in the test tube 36 onto the microplate 48, and take out the microplate 48 from the inlet and outlet 14 of the saliva detection device to perform saliva detection.

[0063] In a specific embodiment of the present invention, a main switch for controlling the operation of the saliva detection device is provided on the top, and a support for easy placement is provided on the bottom; a display 12 and a control key 13 are provided on the front (main view), and the display 12 and the control key 13 are used to regulate the operation of various internal components; a heat dissipation hole is provided on the back; a liquid pump 11 and an infusion pipeline are provided on the left (left view), which are used to add saliva and buffer solution and other liquids to the internal test tube 36; and a control board (circuit board) is provided in the housing 1, and the control board is connected to the external control key 13 and the internal insulation box 2, the liquid pump 11, the turning mechanism 4, the rotating boss 5 and the rotating sub-boss 6, so as to realize the operation control of the whole device; an inlet and outlet 14 is provided on the right (right view), and the microplate 48 and the test tube rack 3 are taken in and out through the inlet and outlet 14 when in use.

[0064] Furthermore, the transmission mechanism comprises: a rotating boss 5 and a rotating sub-boss 6. The rotating sub-boss 6 is rotatably mounted on the rotating boss 5 and is an eccentric device.

[0065] Specifically, there are four rotating sub-bosses 6, which are symmetrical with respect to the center of the rotating boss 5. The test tube rack 3 is mounted on the rotating sub-bosses 6, and the displacement is achieved by the rotation of the rotating boss 5. The rotating boss 5 can achieve the switching (displacement) of the test tube rack 3 between the four positions of the incubator 2, the liquid introduction mechanism, the flip mechanism 4 and the inlet and outlet 14.

[0066] Specifically, four sub-boss mounting holes 51 are evenly arranged on the rotating boss 5 in the circumferential direction, and the rotating sub-boss 6 is rotatably mounted in the sub-boss mounting hole 51 of the rotating boss 5 , that is, the rotating sub-boss 6 can rotate relative to the rotating boss 5 .

[0067] Specifically, an annular groove is provided on the side wall of the sub-boss mounting hole 51, and an annular protrusion is provided on the outer side of the boss disk 61 of the rotating sub-boss 6. The rotating sub-boss 6 and the rotating boss 5 are snap-fitted and installed through the annular groove and the annular protrusion, and the rotating sub-boss 6 can rotate relative to the rotating boss 5.

[0068] Furthermore, the rotating boss 5 and the rotating sub-boss 6 are driven by the motor to rotate along their own axis. Specifically, the rotating boss 5 is driven to rotate by the first motor, and the four rotating sub-bosses 6 are respectively driven to rotate by the four second motors. When the rotating boss 5 rotates, the position of the test tube rack 3 as a whole can be moved, and the test tube rack 3 can be rotated to the position of the incubator 2, the flip mechanism 4, the liquid introduction mechanism or the inlet and outlet 14. When the rotating sub-boss 6 rotates, the rotational movement of the test tube rack 3 relative to its own axis can be realized.

[0069] Specifically, the rotating sub-boss 6 is fixedly connected to the second drive gear 8 via the sub-boss connecting shaft 62, the second drive gear 8 is driven to rotate by the second motor, the rotating boss 5 is fixedly connected to the first drive gear 7, and the first drive gear 7 is driven to rotate by the first motor.

[0070] Furthermore, the rotating sub-boss 6 is connected to the test tube rack 3 through the rough bottom surface, and the test tube rack 3 is used to place the test tube 36. Rotating the rotating sub-boss 6 can drive the test tube 36 to rotate with the test tube rack 3, so as to facilitate adding different liquids into the test tube through different infusion pipes.

[0071] Specifically, a protrusion 63 is provided on the upper surface of the rotating sub-boss 6 , and a recessed hole 37 is provided at the bottom of the test tube rack 3 . The test tube rack 3 is stably mounted on the rotating sub-boss 6 by engaging the recessed hole 37 with the protrusion 63 .

[0072] Furthermore, in order to facilitate the turning of the test tube rack 3, preferably, the protrusion 63 and the recessed hole 37 are both semi-spherical and have a diameter less than 1 mm.

[0073] Further, the test tube rack 3 includes three layers of support plates and an intermediate shaft 34, the support plates are respectively a first support plate 31, a second support plate 32 and a third support plate 33, and the first support plate 31, the second support plate 32 and the third support plate 33 are provided with a plurality of test tube mounting holes 35 evenly distributed circumferentially. Specifically, the test tube mounting holes 35 on the first support plate 31 and the second support plate 32 are through holes, and the test tube mounting holes 35 on the third support plate 33 are blind holes, and the test tubes 36 are nested and installed in the test tube mounting holes 35 of the test tube rack 3.

[0074] Specifically, six test tubes 36 can be installed on a single test tube rack 3 , and the six test tube installation holes 35 are evenly distributed circumferentially on the test tube rack 3 , that is, the multiple test tubes 36 are evenly distributed in the circumferential direction relative to the axis of the intermediate shaft 34 .

[0075] Furthermore, an annular elastic rubber pad is bonded to the surface of the test tube mounting hole. After the test tube 36 is inserted into the test tube rack 3, it can be clamped and fixed by the elastic rubber pad to prevent the test tube 36 from loosening on the test tube rack 3 during the subsequent turning process.

[0076] Furthermore, the liquid introduction mechanism includes: a liquid pump 11 and a liquid infusion pipeline, wherein there are multiple liquid infusion pipelines, which are respectively used to introduce different liquids (saliva, buffer solution, etc.) into the same test tube 36.

[0077] Specifically, the infusion pipeline includes: a first infusion pipeline 111, a second infusion pipeline 112, a third infusion pipeline 113 and a fourth infusion pipeline 114. Furthermore, the outlet ports of the first infusion pipeline 111, the second infusion pipeline 112, the third infusion pipeline 113 and the fourth infusion pipeline 114 are downwardly oriented and symmetrically distributed in the circumferential direction. That is to say, when the rotating sub-boss 6 drives the test tube rack 3 to rotate, the test tube rack 3 rotates around its own central axis (intermediate axis 34), and at the same time drives the test tube 36 to rotate around the central axis of the test tube rack 3, so that the nozzle of the test tube 36 can be aligned with the nozzles of different infusion pipelines in turn, and different liquids (saliva, buffer solution, various dye solutions, etc.) are added to the test tube 36 through different infusion pipelines.

[0078] Furthermore, there is a receiving plate on the left panel of the saliva detection device, on which a filter is placed. The saliva entering the test tube 36 through the infusion pipeline needs to be filtered by the filter before entering the test tube.

[0079] Furthermore, after saliva is injected into the infusion tube, it is necessary to connect the flushing tube to flush and clean it before the next use to remove the residual liquid in the infusion tube.

[0080] Furthermore, the flip mechanism 4 includes: a driving mechanism, a gear rack transmission mechanism, a test tube rack slot 47 and a microplate 48. The driving mechanism of the flip mechanism 4 can flip the test tube rack slot 47 and the microplate 48 through the gear rack transmission mechanism. Then, the test tube rack 3 and the microplate 48 connected to the test tube rack 3 through the test tube rack slot 47 can be flipped, so that the liquid to be tested in the test tube 36 enters the microplate 48, and the test can be performed by taking out the microplate 48 and putting it into the enzyme label detector.

[0081] The test tube rack slot 47 can be engaged with the test tube rack 3 and drive the test tube rack 3 to move synchronously; the microplate 48 can collect the liquid to be tested, and the microplate 48 can be detachably mounted above the test tube rack slot 47 and can move synchronously with the test tube rack slot 47.

[0082] Specifically, the gear rack transmission mechanism includes: a transmission gear 45 and a spur rack 412; the transmission gear 45 is meshed with the spur rack 412, wherein the spur rack 412 is fixedly mounted on the mounting bracket 41 of the flip mechanism 4. The driving mechanism is used to drive the transmission gear 45 to rotate, and when the transmission gear 45 rotates, it can mesh with the spur rack 412 and move up and down relative to the spur rack 412.

[0083] Specifically, the flip mechanism 4 is fixedly mounted on the housing 1 of the saliva detection device via a mounting bracket 41 .

[0084] Specifically, a slide rail 411 , a spur rack 412 and a U-shaped groove 413 are arranged in parallel on the mounting bracket 41 .

[0085] The flip mechanism 4 also includes: a slider 42 and a connecting plate 43; the slider 42 is slidably matched with the slide rail 411, that is, a slide groove is provided on the slider 42, and the slide groove has the same cross section as the slide rail, and the slider 42 can slide up and down relative to the slide rail 411.

[0086] Further, the output end of the driving mechanism is fixedly connected to the slider 42. The slider 42 is connected to the transmission gear 45 through the connecting plate 43. Specifically, the slider 42 is fixedly connected to the connecting plate 43 and moves synchronously; the connecting plate 43 is rotationally connected to the transmission gear 45, that is, the transmission gear 45 can rotate relative to the connecting plate 43.

[0087] Furthermore, the transmission gear 45 is fixedly connected to the test tube rack slot 47 , and the test tube rack slot 47 includes a straight portion and an arc portion, the straight portion is connected to the newly replaced transmission gear 45 , the arc portion cooperates with the test tube rack 3 , and the straight portion is arranged in the U-shaped slot 413 .

[0088] When in use, the flip mechanism 4 drives the slider 42 to slide upward along the slide rail 411 through the driving mechanism, and the connecting plate 43 moves upward. At the same time, the connecting plate 43 drives the transmission gear 45 to move upward and engage the spur rack 412 for transmission. The transmission gear 45 rotates relative to the connecting plate 43 when it engages with the spur rack 412. In other words, the transmission gear 45 moves upward and rotates at the same time, driving the test tube rack slot 47 to move upward along the U-shaped slot, and the test tube rack slot 47 and the microplate 48 move upward and rotate at the same time (i.e. flip), so that the liquid in the test tube 36 is poured onto the microplate 48.

[0089] The microplate 48 is provided with storage holes corresponding to the number of test tubes 36 on the test tube rack 3, for storing the mixed liquid. Furthermore, the size of the storage holes is slightly larger than the diameter of the test tube 36, and after the flip mechanism 4 flips the test tube rack 3, the storage holes of the microplate 48 are aligned with the openings of the test tube 36.

[0090] Specifically, the driving mechanism is a pneumatic cylinder, a hydraulic cylinder or a linear motor.

[0091] Specifically, the test tube rack slot 47 can adopt a clamping claw structure, and the test tube rack 3 can be grasped and released by opening and closing the clamping claw, so that the test tube rack 3 can be turned over with the turning mechanism 4 or transferred by the rotating boss 5.

[0092] Furthermore, behind the saliva testing device is an incubator 2 , which is a box structure and has an arc-shaped passage 21 inside. The arc-shaped passage 21 can allow the test tube rack 3 to pass through, thereby enabling the test tube rack 3 to enter and transfer into the incubator 2 .

[0093] Furthermore, the incubator 2 is also provided with a heating resistor 22 and a temperature sensor 23. The heating resistor 22 can heat the incubator 2, thereby achieving the insulation of the liquid in the test tube 36. The temperature sensor 23 can monitor the temperature of the incubator 2, so that the insulation temperature of the incubator 2 always meets the insulation requirements. That is, the heat generation of the heating resistor 22 is adjusted by the temperature sensor 23, so that the internal temperature of the incubator 2 maintains a stable temperature suitable for saliva storage. When the saliva cannot be tested in time, the test tube rack 3 can be transferred to the incubator 2 for storage through the rotating boss 5.

[0094] In a specific embodiment of the present invention, the incubator 2, the liquid introduction mechanism and the flip mechanism 4 are respectively arranged on the three side panels of the saliva detection device. That is to say, the position of the test tube rack 3 can be switched by rotating the rotating boss 5 by 90°. Figure 6 As shown, the rotating boss 5 rotates 90° clockwise to transfer the test tube rack 3 from below the infusion pipeline to the incubator 2, and the rotating boss 5 rotates 270° clockwise to transfer the test tube rack 3 from below the infusion pipeline to the turning mechanism 4 to fit in the test tube rack slot 47.

[0095] When using:

[0096] Saliva, buffer solution, two different dye solutions and other liquids are added into the test tube 36 through four infusion pipes on the liquid pump 11 .

[0097] If storage is required, the rotating boss 5 is controlled to rotate to rotate the test tube rack 3 into the incubator 2;

[0098] If storage is not required, the test tube rack 3 is directly rotated to the flipping mechanism 4, and the test tube rack 3 is flipped by the flipping mechanism 4 so that the liquid to be tested in the test tube 36 is poured into the microporous plate 48, and the microporous plate 48 is taken out through the inlet and outlet to obtain the liquid to be tested, and then flipped again, and the test tube rack 3 is rotated to the inlet and outlet 14 position, the test tube rack 3 is taken out, and a new test tube 36 is replaced.

[0099] Example 2

[0100] This embodiment provides a detection method of the saliva detection device in Embodiment 1, comprising the following steps:

[0101] Step S1: Turn on the liquid pump 11 to introduce saliva and buffer solution into the test tube 36 on the test tube rack 3 through the infusion pipe.

[0102] Step S2: The first motor drives the rotating boss 5 to rotate, and transfers the test tube rack 3 to the inside of the incubator 2 for insulated heat, waiting for the use of the saliva sample.

[0103] Step S3: when the saliva sample needs to be tested, the first motor is driven to drive the rotating boss 5 to rotate, and the test tube rack 3 is transferred to the flipping mechanism 4 . The test tube rack 3 is flipped by the flipping mechanism 4 , and the liquid in the test tube 36 is introduced into the microplate 48 .

[0104] Step S4: Take out the microplate 48 and perform saliva testing on the saliva sample.

[0105] Furthermore, in step S1, when liquid is introduced into the test tube 36 through the infusion pipe, saliva and buffer solution are introduced through different infusion pipes respectively, and the second motor drives the rotating sub-boss 6 to rotate, and the rotating sub-boss 6 drives the test tube rack 3 to rotate, so that the test tube 36 is aligned with different infusion pipes, and different liquids are introduced into the test tube 36.

[0106] Specifically, the infusion pipeline includes a first infusion pipeline 111, a second infusion pipeline 112, a third infusion pipeline 113 and a fourth infusion pipeline 114. The liquid outlets of the first infusion pipeline 111, the second infusion pipeline 112, the third infusion pipeline 113 and the fourth infusion pipeline 114 are evenly distributed around the circumference.

[0107] In the present invention, the second motor drives the rotating sub-boss 6 to rotate, and the test tube rack 3 rotates 0°, 90°, 180°, and 270° in sequence, so that the test tubes 36 on the test tube rack 3 can be aligned with the first infusion pipeline 111, the second infusion pipeline 112, the third infusion pipeline 113, and the fourth infusion pipeline 114 in sequence, and liquid is added through the first infusion pipeline 111, the second infusion pipeline 112, the third infusion pipeline 113, and the fourth infusion pipeline 114 respectively.

[0108] In step S2, when the rotating boss 5 rotates, the rotating sub-boss 6 and the test tube rack 3 above the rotating sub-boss 6 both rotate around the center of the rotating boss 5. When the rotating boss 5 rotates 90°, the test tube rack 3 enters the incubator 2. When the rotating boss 5 rotates 270°, the test tube rack 3 is transferred to the position of the flipping mechanism 4.

[0109] In the step S3, when the test tube rack 3 is flipped by the flipping mechanism 4, the following steps are included:

[0110] Step S31: the driving mechanism (cylinder, hydraulic cylinder or linear motor) drives the slider 42 to slide upward along the slide rail 411; the connecting plate 43 and the transmission gear 45 synchronize the slider 42 to move upward.

[0111] Step S32: During the upward movement of the transmission gear 45, it meshes with the spur rack 412, that is, the transmission gear 45 rolls upward along the spur rack 412; when the transmission gear 45 rolls upward, the test tube rack slot 47 moves upward and rotates, and at the same time, the test tube rack slot 47 drives the test tube rack 3 to flip over, and the liquid in the test tube 36 is poured onto the microplate 48.

[0112] Step S33 : the micro-well plate 48 falls onto the rotating sub-boss 6 below and can be transferred in position through the rotating boss 5 .

[0113] Furthermore, the flipping mechanism has the function of shaking the test tube to mix the liquid in addition to the function of pouring the liquid when taking it; specifically:

[0114] The turning mechanism 4 drives the transmission gear 45 to reciprocate up and down along the spur rack 412 through the driving mechanism 44, thereby shaking the test tube rack slot 47 and the test tube rack 3 left and right to mix the liquid in the test tube 36. The turning mechanism 4 can replace the process of manually shaking the test tube, which is convenient for subsequent detection and saves manpower.

[0115] In step S4, an inlet and outlet 14 is provided on the right side of the saliva detection device, and the rotating boss 5 transfers the microplate 48 to the position of the inlet and outlet 14. The detection personnel take out the microplate 48 from the inlet and outlet 14 and analyze and detect the liquid in the microplate 48.

[0116] Compared with the prior art, the present invention has at least one of the following beneficial effects:

[0117] The present invention is small in size, low in cost, can quickly and conveniently collect and test saliva, and can obtain relatively complete and reliable test results, so it is particularly suitable for saliva testing in dental clinics.

[0118] 1. The present invention is provided with an incubator 2, and the heat generation of the heating resistor 22 is adjusted by the temperature sensor 23, so that the inside of the incubator 2 maintains a stable temperature suitable for saliva storage, so as to realize constant temperature storage of saliva when the saliva cannot be tested in time.

[0119] 2. The present invention can perform operations such as adding different liquids and filtering saliva through multiple infusion tubes, thereby improving the efficiency of saliva testing in dental clinics and reducing labor costs.

[0120] 3. The present invention is easy and quick to operate. The automatic operation of the mechanism can be achieved by manually pressing buttons, without the need for high technical operation levels, and is less time-consuming, thereby improving the efficiency of oral health examinations.

[0121] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by any technician familiar with the technical field within the technical scope disclosed by the present invention should be covered within the protection scope of the present invention.

Claims

1. A saliva detection device, characterized in that: include: A test tube rack (3), a liquid introduction mechanism, a rotating boss (5) and a rotating sub-boss (6); the rotating boss (5) is rotatably mounted on the bottom of the saliva detection device; the rotating sub-boss (6) is rotatably mounted on the rotating boss (5); the test tube rack (3) is placed on the rotating sub-boss (6); a test tube (36) for collecting liquid is installed in the test tube rack (3); The rotating boss (5) and the rotating sub-boss (6) are driven to rotate by the first motor and the second motor respectively; when the rotating boss (5) rotates, the position of the test tube rack (3) can be transferred, and when the rotating sub-boss (6) rotates, the test tube rack (3) can be rotated along its own axis; A flipping mechanism (4) is also provided; the flipping mechanism (4) comprises: a driving mechanism (44), a transmission mechanism and a test tube rack slot (47); the flipping mechanism (4) can flip the test tube rack (3); the test tube rack slot (47) can be engaged with the test tube rack (3); the driving mechanism (44) can drive the test tube rack slot (47) to flip through the transmission mechanism; the microplate (48) can be detachably mounted on the test tube rack slot (47); after the test tube rack (3) and the test tube (36) are flipped, the microplate (48) is located below the test tube rack (3).

2. The saliva detection device according to claim 1, characterized in that: The rotating sub-boss (6) is eccentrically arranged on the rotating boss (5).

3. The saliva detection device according to claim 2, characterized in that: There are four rotating sub-bosses (6), which are evenly distributed circumferentially on the rotating boss (5).

4. The saliva detection device according to claim 1, characterized in that: The liquid introduction mechanism comprises a liquid pump (11) and a liquid infusion pipeline.

5. The saliva detection device according to claim 1, characterized in that: Also includes: An insulated box (2); the insulated box (2) can insulate the liquid in the test tube (36).

6. The saliva detection device according to claim 1, characterized in that: The test tube rack (3) is provided with a plurality of test tube mounting holes (35); the test tubes (36) are arranged in the test tube mounting holes (35).

7. The saliva detection device according to claim 6, characterized in that: An elastic rubber pad is provided on the test tube mounting hole (35).

8. The saliva detection method according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step S1: Turn on the liquid pump (11) to introduce saliva and buffer solution into the test tube (36) on the test tube rack (3) through the infusion pipe; Step S2: The first motor drives the rotating boss (5) to rotate, and transfers the test tube rack (3) to the inside of the incubator (2) for incubation, waiting for the use of the saliva sample; Step S3: When a saliva sample needs to be tested, the liquid in the test tube (36) is poured into the microplate (48); Step S4: Take out the microplate (48) and perform saliva testing on the saliva sample.

9. The detection method of the saliva detection device according to claim 8, characterized in that: In the step S1, when liquid is introduced into the test tube (36) through the infusion pipeline, saliva, buffer solution and dye solution are introduced through different infusion pipelines respectively.

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