A pesticide tank-mix adjuvant composition and its preparation method and application

Abstract

The present invention relates to a pesticide tank-mix adjuvant composition, a preparation method and an application thereof, wherein the pesticide tank-mix adjuvant composition comprises at least one polyethylene glycol, and the molecular weight of the polyethylene glycol is 200 to 20000 Da. The pesticide tank-mix adjuvant composition of the present invention can effectively improve the effect of the pesticide preparation on the target.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticides, and specifically relates to a pesticide tank-mix adjuvant composition, a preparation method and an application thereof. Background Art

[0002] Pesticide tank-mix adjuvants refer to adjuvants that are added directly to the spray barrel or medicine box before spraying pesticides. After being evenly mixed with the pesticides, they can improve the performance of the pesticide solution. Using tank-mix adjuvants to increase the efficiency of pesticides is one of the important measures to "reduce the amount and increase the efficiency". The main function of tank-mix adjuvants is to improve the physical and chemical properties of the pesticide solution and increase the efficiency of the active ingredients reaching the site of action.

[0003] The tank-mix adjuvants currently sold in the pesticide market are mainly silicones, vegetable oils, mineral oils, inorganic salts, polymers and mixtures of these.

[0004] Polyethylene glycol (also known as PEG) is a high molecular polymer, which is formed by the gradual addition polymerization of ethylene oxide and water or ethylene glycol. It has good water solubility and good compatibility with many organic components. Polyethylene glycol is an inert substance with low self-reactivity and is non-toxic. PEG is often used as an inert excipient for the preparation of intramuscular injection drugs, a base material for commonly used oral drugs, a thickener for syrups in the food industry, a coating and additive for tablets, and a thickening or viscosity-enhancing excipient in pesticides.

[0005] However, the ability of PEG to enhance the target effects of certain pesticides / or certain types of pesticides has not yet been discovered. Summary of the invention

[0006] In view of this, the main purpose of the present invention is to provide a pesticide tank-mix adjuvant composition and a preparation method and application thereof. The technical problem to be solved is that by using the tank-mix adjuvant composition, the absorption and conduction of the agent can be significantly promoted, the efficacy of the pesticide can be greatly improved, the cost of medication can be reduced, the generation of pesticide resistance can be slowed down, and the ecological environment can be protected.

[0007] In order to achieve the above-mentioned object, the present invention provides a pesticide tank-mix adjuvant composition, wherein the pesticide tank-mix adjuvant composition comprises at least one polyethylene glycol, and the molecular weight of the polyethylene glycol is 200 to 20,000 Da.

[0008] Preferably, the pesticide tank-mix adjuvant composition comprises polyethylene glycol 400 and polyethylene glycol 800.

[0009] Preferably, the mass ratio of polyethylene glycol 400 to polyethylene glycol 800 is 5:5-9:1.

[0010] Preferably, the pesticide tank-mix adjuvant composition further comprises at least one of silicones, vegetable oils, mineral oils, inorganic salts and other polymers.

[0011] In order to achieve the above-mentioned object, the present invention also provides a method for preparing a pesticide tank-mix adjuvant composition, comprising the following steps:

[0012] The at least one polyethylene glycol is stirred evenly and then allowed to stand for 10 to 30 minutes to obtain the pesticide tank-mix adjuvant composition.

[0013] Preferably, at least one of the polyethylene glycols comprises polyethylene glycol 400 and polyethylene glycol 800.

[0014] Preferably, the mass ratio of polyethylene glycol 400 to polyethylene glycol 800 is 5:5-9:1.

[0015] Preferably, at least one polyethylene glycol is uniformly stirred with at least one of silicones, vegetable oils, mineral oils, inorganic salts and other polymers and then allowed to stand for 10 to 30 minutes.

[0016] Preferably, the stirring speed is 150 to 3000 rpm, and the stirring time is 0.2 to 1 min.

[0017] Preferably, the stirring is performed using an electric stirring instrument.

[0018] In order to achieve the above-mentioned purpose, the present invention also provides a method for using the pesticide tank-mix adjuvant composition, which comprises diluting the above-mentioned pesticide tank-mix adjuvant composition with water to form a 0.04wt% to 0.1wt% solution, and then using the solution to dilute the pesticide preparation for subsequent spraying.

[0019] Preferably, the water is tap water or irrigation water.

[0020] Preferably, the pesticide formulation is selected from insecticides, fungicides, herbicides or plant growth regulators.

[0021] Preferably, the dilution factor is 2500-5000 times.

[0022] Preferably, the spraying pressure is 0.15-0.50 MPa, the nozzle diameter is 0.8-1 mm, and the flow rate is 50-75 L / h.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] The pesticide tank-mix adjuvant composition of the present invention is diluted with water to a solution of 0.04wt% to 0.1wt%, and the solution is then used to dilute the pesticide preparation for subsequent spraying, which can effectively improve the physical and chemical properties of the pesticide solution, increase the efficiency of the active ingredients reaching the site of action, and thus improve the effect of the pesticide preparation on the target, such as increasing the mortality rate of pests when the same dose of the pesticide preparation is applied. DETAILED DESCRIPTION

[0025] In order to further explain the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the following is a detailed description of a pesticide tank-mix adjuvant composition and its preparation method and application according to the present invention, its specific implementation method, characteristics and performance in combination with the preferred embodiments. In the following description, different "one embodiment" or "embodiment" does not necessarily refer to the same embodiment. In addition, specific features, structures or characteristics in one or more embodiments may be combined in any suitable form.

[0026] The following materials or reagents, unless otherwise specified, were purchased from the market.

[0027] The method provided by the present invention is further illustrated by the following examples, but is not limited to the following examples.

[0028] It should be noted that the following detailed descriptions are exemplary and are intended to provide further explanation of the present invention. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present invention belongs.

[0029] Example 1

[0030] Polyethylene glycol 400 and polyethylene glycol 800 were uniformly mixed at a ratio of 5:5 (mass ratio) using an electric stirring instrument to obtain a pesticide tank-mix adjuvant composition.

[0031] Example 2

[0032] Polyethylene glycol 400 and polyethylene glycol 800 were uniformly mixed in a ratio of 6:4 (mass ratio) using an electric stirring instrument to obtain a pesticide tank-mix adjuvant composition.

[0033] Example 3

[0034] Polyethylene glycol 400 and polyethylene glycol 800 were uniformly mixed at a ratio of 9:1 (mass ratio) using an electric stirring instrument to obtain a pesticide tank-mix adjuvant composition.

[0035] Example 4

[0036] Polyethylene glycol 400 and polyethylene glycol 800 were uniformly mixed in a ratio of 6:3 (mass ratio) using an electric stirring instrument to obtain a pesticide tank-mix adjuvant composition.

[0037] Example 5

[0038] Polyethylene glycol 400 and polyethylene glycol 800 were uniformly mixed in a ratio of 6:2 (mass ratio) using an electric stirring instrument to obtain a pesticide tank-mix adjuvant composition.

[0039] Example 6

[0040] Polyethylene glycol 400 and polyethylene glycol 800 were uniformly mixed at a ratio of 6:1 (mass ratio) using an electric stirring instrument to obtain a pesticide tank-mix adjuvant composition.

[0041] Comparative Example 1

[0042] Polyethylene glycol 400 and polyethylene glycol 800 were uniformly mixed in a ratio of 1:2 (mass ratio) using an electric stirring apparatus to obtain an auxiliary agent composition.

[0043] Comparative Example 2

[0044] Polyethylene glycol 400 and polyethylene glycol 800 were uniformly mixed at a ratio of 10:1 (mass ratio) using an electric stirring apparatus to obtain an auxiliary agent composition.

[0045] Application Example 1

[0046] In order to compare the synergistic effect of the pesticide tank-mix adjuvant composition described in Examples 1-6, the lethal concentration (LC) of the pesticide solution to the pests was measured indoors. 50 ), further calculate the synergistic ratio of different treatments, and compare the synergistic effects of different treatments by the size of the synergistic ratio. The specific method is as follows: the pesticide tank-mixed adjuvant composition described in Examples 1-6 and Comparative Examples 1-2 is first diluted with sterile water to a 0.08% (volume ratio) solution, and then the pesticide preparation (avermectin wettable powder with an active ingredient concentration of 1.8% by mass) is diluted with the diluted solution to five gradient solutions of 6.3 mg / L, 1.26 mg / L, 0.252 mg / L, 0.05 mg / L, and 0.01 mg / L, and the five gradient solutions are used to perform biological testing with the citrus fruit fly as the target; at the same time, the pesticide preparation (avermectin wettable powder with an active ingredient concentration of 1.8% by mass) is diluted with sterile water to five gradient solutions of 6.3 mg / L, 1.26 mg / L, 0.252 mg / L, 0.05 mg / L, and 0.01 mg / L, with the citrus fruit fly as the target, as a control without an adjuvant.

[0047] The number of dead insects was investigated 24 h after each treatment, and the mortality rate under different concentrations was calculated. The LC was calculated using Poloplus software (LeOra Software). 50 , further calculate the efficiency ratio, the calculation method of the efficiency ratio is as follows:

[0048] Synergistic ratio = LC of pesticide formulation 50 / LC of mixture of (pesticide formulation + tank-mixed adjuvant) 50

[0049] If the synergistic ratio is greater than 1, it means that the tank-mixed adjuvant has a synergistic effect; if the synergistic ratio is less than 1, it means that the tank-mixed adjuvant has an antagonistic effect. The synergistic ratio results of different treatments are shown in Table 1 below. The larger the synergistic ratio, the stronger the synergistic effect.

[0050] Table 1

[0051]

[0052]

[0053] It can be seen from the data in Table 1 that the synergistic ratios of the pesticide tank-mix adjuvant compositions of Examples 1-6 are much higher than the synergistic ratios of the pesticide tank-mix adjuvant compositions of Comparative Examples 1-2. Example 1 has the strongest synergistic effect, with a synergistic ratio of 8.9, while Example 3 has the weakest synergistic effect, with a synergistic ratio of 3.7.

[0054] Application Example 2

[0055] In order to compare the synergistic effect of different dilution concentrations of the pesticide tank-mixed adjuvant composition described in Example 1, the pesticide tank-mixed adjuvant composition described in Example 1 was diluted with sterile water to solutions with a volume ratio of 0.03%, 0.05%, and 0.08%, respectively, and then the pesticide preparation (avermectin wettable powder with a mass ratio of 1.8% active ingredient concentration) was diluted with solutions of different concentrations to form a series of gradient solutions. The LC of different treatments on pests was determined indoors. 50 , further calculate the efficiency ratio, the specific method is the same as that of Application Example 1. The test results are shown in Table 2.

[0056] Table 2

[0057] deal with <![CDATA[LC 50 (95% confidence interval) / mg·L -1 ]]> Efficiency ratio Pesticide preparation (1.8% avermectin wettable powder) 0.563(0.334～0.95) - 0.03% of the pesticide tank-mix adjuvant composition solution described in Example 1 0.091(0.032～0.229) 6.2 0.05% of the pesticide tank-mix adjuvant composition solution described in Example 1 0.082(0.029～0.146) 6.8 0.08% of the pesticide tank-mix adjuvant composition solution described in Example 1 0.076(0.024～0.195) 7.4

[0058] The results in Table 2 show that the synergistic ratio of using 0.08% pesticide tank-mixed adjuvant composition solution is 1.2 higher than that of 0.03% pesticide tank-mixed adjuvant composition solution, and 0.6 higher than that of 0.05% pesticide tank-mixed adjuvant composition solution. The synergistic effect of 0.08% pesticide tank-mixed adjuvant composition solution is the strongest.

[0059] Application Example 3

[0060] In order to compare the synergistic effect of the pesticide tank-mix adjuvant composition described in Example 1 with the synergistic effect of commonly used commercial tank-mix adjuvants, the pesticide tank-mix adjuvant composition described in Example 1 and the commonly used commercial tank-mix adjuvants were mixed. (Chengdu Jijian Biotechnology Co., Ltd.) were diluted with sterile water to 0.08% (volume ratio) solutions, and then the diluted solutions were used to dilute the pesticide preparation (avermectin wettable powder with a mass ratio of active ingredient concentration of 1.8%) into a series of gradient solutions. The LC of the solutions on pests was measured indoors. 50, and further calculate the efficiency ratio. The specific method is the same as that of Application Example 1. The test results are shown in Table 3.

[0061] Table 3

[0062] deal with <![CDATA[LC 50 (95% confidence interval) / mg·L -1 ]]> Efficiency ratio Pesticide preparation (1.8% avermectin wettable powder) 1.02(0.607～1.595) - 0.08% pesticide tank mix adjuvant composition solution 0.082(0.029～0.146) 12.4 0.08% of the 0.11(0.044～0.259) 9.3

[0063] The results in Table 3 show that the use of the pesticide tank-mix adjuvant composition described in Example 1 has a significant synergistic effect, with a synergistic ratio of up to 12.4, and is 3.1 higher than the synergistic effect of the commonly used commercial adjuvant (0.08% Jijian), indicating that the pesticide tank-mix adjuvant composition described in Example 1 has a significant effect of increasing the mortality rate of target pests, and the effect is higher than that of commonly used commercial adjuvants. Therefore, the pesticide tank-mix adjuvant composition has a high potential commercial value.

[0064] Application Example 4

[0065] This application example is a field application example.

[0066] Treatment area 1 is a solution in which the pesticide tank-mixed adjuvant composition described in Example 1 is diluted to 0.08% (volume ratio) with field irrigation water, and then the avermectin wettable powder with a mass ratio of 1.8% active ingredient concentration is diluted 2500 times with this solution, and a backpack electric sprayer is used to spray the citrus trees (pressure is 0.25MPa, spray hole diameter is 1mm, flow rate is 75L / h). The drug control area 1 is a avermectin wettable powder with a mass ratio of 1.8% active ingredient concentration, which is diluted 2500 times with irrigation water by mass ratio, and the application method is the same as before. At the same time, a control area with clear water without drug application is set up. 14 days and 21 days after the application of the drug, the prevention effect on citrus fruit fly is tested, and the test results are shown in Table 1 below. From the data in Table 1, it can be seen that 14 days after the application of the pesticide, the fruit preservation effect of the citrus trees in the treatment area 1 was 10% higher than that in the pesticide control area 1; 21 days after the application of the pesticide, the fruit preservation effect of the citrus trees in the treatment area 1 was 3% higher than that in the pesticide control area 1. This shows that the addition of the tank-mixed adjuvant described in Example 1 to the pesticide formulation has a significant synergistic effect. The results are shown in Table 4.

[0067] Table 4

[0068]

[0069] Note:

[0070] Fruit preservation effect % = [(fruit worm rate in the clear water control area - fruit worm rate in the treatment area) / fruit worm rate in the clear water control area] × 100

[0071] The insect fruit rate refers to the ratio of the number of citrus fruit infested by the fruit fly found in the survey to the total number of fruits surveyed.

[0072] Application Example 5

[0073] This application example is a field application example.

[0074] Treatment area 2 is a solution in which the pesticide tank-mixed adjuvant composition described in Example 1 is diluted to 0.04% (volume ratio) with field irrigation water, and then the solution is used to dilute the mass ratio of 5% emamectin salt water dispersible granules by mass ratio, and sprayed with an electric sprayer (pressure is 0.15MPa, spray hole diameter is 0.8mm, flow rate is 50L / h) on corn damaged by fall armyworm. The control area 2 is a 5% emamectin salt water dispersible granules with a mass ratio of active ingredient concentration, which is diluted 5000 times by mass ratio with irrigation water, and the application method is the same as before. At the same time, a control area for clear water without pesticide application is set. Three days after the application of the drug, the inspection results are shown in Table 2 below. It can be seen from the data in Table 2 that compared with the control area 2, the control effect of the 5% emamectin salt water dispersible granules + the barrel-mixed pesticide adjuvant composition described in Example 1 on the larvae of fall armyworm is increased by 8.3% compared with the control area 2. This indicates that adding the tank-mix adjuvant described in Example 1 to the pesticide formulation has a significant synergistic effect. The results are shown in Table 5.

[0075] Table 5

[0076] deal with Corrected protection effect / % Drug control area 2 (5% emamectin benzoate saline dispersible granules) 87.5 Treatment area 2 (5% emamectin benzoate dispersible granules + the pesticide adjuvant composition described in Example 1) 95.8

[0077] Note:

[0078] Larvae control effect (%) = [(number of larvae in the clean water control area - number of larvae in the treatment area) / number of larvae in the clean water control area}] × 100 The above embodiments are only used for the technical solutions of the present invention, but not for limiting the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, it should be understood by those skilled in the art that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features thereof may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A pesticide tank-mix adjuvant composition, characterized in that: The auxiliary agent composition comprises polyethylene glycol 400 and polyethylene glycol 800, The mass ratio of polyethylene glycol 400 to polyethylene glycol 800 is 5:5-9:1, and the active ingredient of the pesticide is avermectin or emamectin benzoate.

2. A method for preparing the pesticide tank-mix adjuvant composition according to claim 1, characterized in that: The following steps are involved: The polyethylene glycol 400 and the polyethylene glycol 800 are uniformly stirred and then allowed to stand for 10 to 30 minutes to obtain the pesticide tank-mix adjuvant composition.

3. A method for using a pesticide tank-mix adjuvant composition, comprising diluting the adjuvant composition according to claim 1 with water to form a 0.02wt% to 0.08wt% solution, and then using the solution to dilute the pesticide preparation for subsequent spraying, wherein the active ingredient of the pesticide is avermectin or emamectin benzoate.

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