A solid-liquid separation device for heparin sodium production

Abstract

The present invention discloses a solid-liquid separation device for sodium heparin production in the technical field of three-phase separation devices, comprising a base and a separation drum arranged on the base, a first motor is arranged on the base on one side of the separation drum, the output shaft end of the first motor drives the central shaft of the separation drum to rotate via a pulley, a second motor is arranged on the base on the other side of the separation drum, the second motor is connected to a water pump, the outer water pumping pipe of the water pump is connected to the inner water pumping pipe inside the separation drum through an annular circular tube connected to the separation drum; both ends of the central shaft extend to the outside of the separation drum and are fixed on bearing seats at both ends, the separation drum comprises a rotating net that can rotate with the central shaft, and a solid discharge pipe is also arranged at a position where the outer shell of the separation drum is flush with the horizontal axis of the central shaft. The present invention can make the solid-liquid phase separation thorough, improve the solid-liquid phase separation effect, and avoid the accumulation of odor in the separation device, and is suitable for use in the processing system of sodium heparin production.

Description

Technical Field

[0001] The present invention relates to the technical field of three-phase separation devices in the production of heparin sodium, in particular to a solid-liquid separation device for the production of heparin sodium. Background Art

[0002] Heparin sodium is an anticoagulant, a mucopolysaccharide substance, the sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle, and sheep. It is naturally present in the human blood. Heparin sodium has the effects of preventing platelet aggregation and destruction, inhibiting the conversion of fibrinogen to fibrin monomers, inhibiting the formation of thrombin and antagonizing existing thrombin, and preventing the conversion of prothrombin to thrombin and antagonizing thrombin.

[0003] In the extraction and production of sodium heparin, the small intestines of raw materials such as pigs, cattle, and sheep must first be pre-treated. However, the small intestine contains a large amount of connective tissue, which can easily form entanglements in the solid-liquid separation device and is difficult to clean, causing blockage inside the device, resulting in poor separation efficiency and effect of the separation device. In addition, odor is also generated during the production of sodium heparin, which can easily cause extreme olfactory discomfort to the human body. Therefore, the separation device needs to be connected to an odor treatment device to collect the odor for centralized treatment. However, when the device is congested, the discharge of odor is restricted, and the odor content in the separation device is high, which also poses certain safety hazards.

[0004] The Chinese patent database discloses a high-speed liquid-liquid-solid three-phase centrifuge for extracting porcine-derived sodium heparin. The centrifuge comprises a base, a rotating drum, a first drive motor, a differential, a heavy liquid pipe mounted on the top right side of the drum, a light liquid pipe mounted on the bottom right side of the drum, and a solid phase pipe mounted on the bottom left side of the drum, along with a spiral. The top of the base is fixedly connected to the drum via a support column, and the differential is mounted on the side end of the drum. The centrifugal force generated by the spiral achieves solid-liquid separation, enhancing the separation efficiency of the three-phase centrifuge. The centrifugal force increases the feed rate by replacing the straight feed pipe with a spiral pipe. However, the disadvantages of this centrifuge are that the porcine solids tend to become entangled between the spiral pipe and the drum, causing blockage and compromising the solid-liquid separation efficiency of the device. Furthermore, the separation of the heavy and light liquids is incomplete, with the heavy liquid discharge often containing a significant amount of light liquid, resulting in poor separation efficiency. Summary of the Invention

[0005] The purpose of the present invention is to overcome the defects in the prior art and provide a solid-liquid separation device for the production of heparin sodium, so that the solid-liquid phase separation is thorough, the solid-liquid phase separation effect is improved, and the accumulation of odor in the separation device is avoided.

[0006] The objective of the present invention is achieved as follows: A solid-liquid separation device for the production of sodium heparin comprises a base and a separation drum arranged on the base, a first motor is provided on the base on one side of the separation drum, the output shaft end of the first motor drives the central rotating shaft of the separation drum to rotate via a pulley, a second motor is provided on the base on the other side of the separation drum, the second motor is connected to a water pump, the outer water pumping pipe of the water pump is connected to the inner water pumping pipe inside the separation drum through an annular circular tube connected to the separation drum; both ends of the central rotating shaft extend to the outside of the separation drum and are fixed to the bearing seats at both ends, the separation drum comprises a rotating net that can rotate with the central rotating shaft, and a solid discharge pipe is also provided at a position where the outer shell of the separation drum is flush with the horizontal axis of the central rotating shaft.

[0007] Furthermore, the annular tube is sleeved on one end of the central rotating shaft, and a gap is left between the annular tube and the central rotating shaft. The external water pumping pipe connected to the water pump and the internal water pumping pipe arranged in the separation drum are connected through the annular tube. A bearing sleeve for fixing the annular tube is provided on the separation drum shell where the annular tube and the central rotating shaft are connected, and a sealing ring is provided between the annular tube and the separation drum shell; a gap is left between the annular tube and the central rotating shaft, and when the central rotating shaft rotates, the annular tube will not rotate with the central rotating shaft, thereby avoiding the entanglement of the internal water pumping pipe in the separation drum and ensuring the safety and stability of the water pumping pipeline; the setting of the sealing ring ensures the airtightness of the connection between the water pumping end pipelines, ensuring that the liquid in the separation drum will not leak out.

[0008] Furthermore, a filter cover with a small retention hole is sleeved on the outer periphery of the water pumping end of the inner water pumping pipe, and a large retention hole is provided on the inner water pumping pipe corresponding to the small retention hole, and the aperture of the large retention hole is larger than the aperture of the small retention hole; the filter cover can further retain the solids in the separation drum to prevent them from being sucked into the water pump and affecting the safe and stable operation of the water pump. The filter cover provides double-layer protection for the inner water pump, and the small retention hole can improve the retention accuracy of the filter cover.

[0009] Furthermore, a conveyor belt is provided in the solid discharge pipe, and the conveyor belt is wound around the first roller and the second roller. A scraping paddle and a scraper are provided above the second roller. One end of the scraper is rotatably connected to the scraping paddle, and the other end is in conflict with the dense filter screen arranged on the surface of the rotating net. The upper surface of the scraper is a smooth plane. The scraper is kept at a certain distance from the surface of the rotating net by the scraping paddle, so that the scraper does not stick tightly to the surface of the rotating net to avoid damage during rotation, and does not stay too far away from the surface of the rotating net to scrape off the solids. The solids scraped off by the scraper slide along the scraper surface to the conveyor belt and are discharged from the solid discharge pipe.

[0010] Furthermore, the central rotating shaft is a hollow shaft with a plurality of through holes formed thereon. The other end of the central rotating shaft opposite to the annular circular tube is connected to the air extraction component via a rotary joint.

[0011] Furthermore, the vacuum assembly includes an vacuum pump, the vacuum pipe of the vacuum pump is connected to the rotary joint and is connected to the central rotating shaft, the vacuum pump is connected to an eccentric retaining ring through a baffle, the outer periphery of the eccentric retaining ring is at different distances from the inner shell of the vacuum pump, when the vacuum pump starts working, the air pressure at the large spacing is small, and the air pressure at the small spacing is large, the uneven pressure of the gas in the pump forms a pressure difference, and the atmospheric pressure at the small spacing is squeezed toward the small air pressure at the large spacing. Under the action of the vacuum pump, the discharge of odor in the separation drum is accelerated, and the rotary joint can prevent the vacuum pipe from rotating with the central rotating shaft, avoid the vacuum pipe from being entangled, and ensure the safety and stability of the vacuum pipeline.

[0012] During operation, the present invention separates the solid-liquid mixture within the separation drum. Solids such as connective tissue adhering to the casings are separated from the liquid as the separation drum rotates and then discharged through a solids discharge pipe. The liquid within the separation drum is discharged through an external pump. Compared with the prior art, the present invention has the following advantages: the solid-liquid mixture is separated during continuous rotation and mixing by providing a rotating screen. Solids adhering to the rotating screen are removed and discharged by scrapers provided above the solids discharge pipe as the screen rotates. The interior of the separation drum is in a negative pressure state, which allows the solids to be firmly adhered to the rotating screen. As the screen rotates, they are scraped and discharged by the scrapers. This reciprocating cycle continuously separates the solid-liquid mixture within the separation drum, achieving a thorough separation effect and preventing congestion within the device caused by fixed objects. The present invention can be used in a processing system for the production of sodium heparin. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 The figure is a schematic structural diagram of the solid-liquid separation device for heparin sodium production according to the present invention.

[0014] Figure 2 for Figure 1 Section view in the AA direction.

[0015] Figure 3 for Figure 1 Cross-sectional view along the BB direction.

[0016] Figure 4 for Figure 2 Enlarged schematic diagram of point M in the middle.

[0017] Among them, 1 separation drum, 2 rotary screen, 3 dense filter screen, 4 scraper, 5 solid discharge pipe, 6 conveyor belt, 7 scraper paddle, 8 first roller, 9 second roller, 10 first motor, 11 rotary joint, 12 center shaft, 13 bearing seat, 14 inner water extraction pipe, 15 annular circular pipe, 16 outer water extraction pipe, 17 water extraction pump, 18 second motor, 19 filter cover, 20 small retention hole, 21 large retention hole, 22 air extraction pump, 23 eccentric retaining ring, 24 through hole, 25 bearing sleeve, 26 sealing ring. DETAILED DESCRIPTION

[0018] like Figures 1 to 4 A solid-liquid separation device for the production of sodium heparin is shown, comprising a base and a separation drum 1 arranged on the base. A first motor 10 is provided on the base on one side of the separation drum 1. The output shaft end of the first motor 10 drives the central rotating shaft 12 of the separation drum 1 to rotate via a pulley. A second motor 18 is provided on the base on the other side of the separation drum 1. The second motor 18 is connected to a water pump 17. The outer water pump pipe 16 of the water pump 17 is connected to the inner water pump pipe 14 inside the separation drum 1 through an annular circular tube 15 connected to the separation drum 1; both ends of the central rotating shaft 12 extend to the outside of the separation drum 1 and are fixed to bearing seats 13 at both ends. The separation drum 1 includes a rotating net 2 that can rotate with the central rotating shaft 12. A solid discharge pipe 5 is also provided on the outer shell of the separation drum 1 at a position flush with the horizontal axis of the central rotating shaft 12.

[0019] The annular tube 15 is sleeved on one end of the central rotating shaft 12, and a gap is left between the annular tube 15 and the central rotating shaft 12. The external water pumping pipe 16 connected to the water pump 17 and the internal water pumping pipe 14 arranged in the separation drum 1 are connected through the annular tube 15. A bearing sleeve 25 for fixing the annular tube 15 is provided outside the separation drum 1 where the annular tube 15 and the central rotating shaft 12 are connected, and a sealing ring 26 is provided between the annular tube 15 and the outer shell of the separation drum 1; through the bearing sleeve 25 and the gap left between the annular tube 15 and the central rotating shaft 12, when the central rotating shaft 12 rotates, the annular tube 15 will not rotate with the central rotating shaft 12, thereby avoiding the entanglement of the internal water pumping pipe 15 in the separation drum 1, ensuring the safety and stability of the water pumping pipeline; the setting of the sealing ring 26 ensures the airtightness of the connection between the water pumping end pipelines, ensuring that the liquid in the separation drum 1 will not leak out.

[0020] A filter cover 19 with a small retention hole 20 is sleeved on the outer periphery of the water pumping end of the inner water pumping pipe 14, and a large retention hole 21 is provided on the inner water pumping pipe 14 corresponding to the small retention hole 20, and the aperture of the large retention hole 21 is larger than the aperture of the small retention hole 20; the filter cover 19 can further retain the solids in the separation drum 1, preventing the solids from being sucked into the water pump 17 and affecting the safe and stable operation of the water pump 17. The filter cover 19 provides double-layer protection for the inner water pump 14, and the small retention hole 20 can improve the retention accuracy of the filter cover 19.

[0021] A conveyor belt 6 is provided in the solid discharge pipe 5, and the conveyor belt 6 is wound around the first roller 8 and the second roller 9. A scraping paddle 7 and a scraper 4 are provided above the second roller 9. One end of the scraper 4 is rotatably connected to the scraping paddle 7, and the other end is in contact with the dense filter 3 arranged on the surface of the rotary net 2. The upper surface of the scraper 4 is a smooth plane; the scraping paddle 7 is used to keep a certain distance between the scraper 4 and the surface of the rotary net 2, so that the scraper 4 does not stick tightly to the surface of the rotary net 2, or even press the rotary net 2 downward, thereby avoiding damage to the rotary net 2, and not being too far away from the surface of the rotary net 2 to scrape off the solids. The solids scraped off by the scraper 4 slide along the surface of the scraper 4 to the conveyor belt 6 and are discharged from the solid discharge pipe 5.

[0022] The central rotating shaft 12 is a hollow shaft with a plurality of through holes formed therein. The other end of the central rotating shaft 12 opposite to the annular tube 15 is connected to the air extraction assembly via a rotary joint 11 .

[0023] The air extraction component includes an air extraction pump 22. The air extraction pipe of the air extraction pump 22 is connected to the rotary joint 11 and is connected to the central rotating shaft 12. The interior of the air extraction pump 22 is connected to an eccentric retaining ring 23 through a baffle. The outer periphery of the eccentric retaining ring 23 is at different distances from the inner shell of the air extraction pump 22. When the air extraction pump 22 starts working, the interior of the separation drum 1 is in a negative pressure state. The air pressure at the large spacing is small, and the air pressure at the small spacing is large. The uneven air pressure in the pump forms a pressure difference. The atmospheric pressure at the small spacing is squeezed toward the small air pressure at the large spacing, which can accelerate the discharge of odor in the separation drum 1. The rotary joint 11 can prevent the air extraction pipe of the air extraction pump 22 from rotating with the central rotating shaft 12, avoid entanglement of the air extraction pipe, and ensure the safety and stability of the air extraction pipeline.

[0024] When the present invention is working, the solid-liquid mixture is separated by the separation drum 1, and the solids such as connective tissue adhered to the casing are separated from the liquid as the separation drum 1 rotates, and then discharged through the solid discharge pipe. The liquid in the separation drum 1 is discharged through the external water pump 17. Specifically, the first motor 10 drives the central shaft 12 to rotate counterclockwise through the pulley, and drives the separation drum 1 installed on the central shaft 12 to rotate counterclockwise. A solid discharge pipe 5 is provided on the outer shell of the separation drum 1 at a position flush with the horizontal axis of the separation drum 1. A first roller 8 and a second roller 9 are installed in the solid discharge pipe 5, and a conveyor belt 6 is wound thereon. A shovel and scraper are installed above the second roller 9. The scraper 4 is rotatably connected to the scraper paddle 7, and the front end of the scraper 4 is in contact with the rotary screen 2 of the separation drum 1. The surface of the rotary screen 2 is a dense filter screen 3. The scraper 4 is adjusted to a suitable position by the scraper paddle 7, that is, the scraper will not be tightly attached to the surface of the rotary screen 2 to cause damage to the rotary screen 2, nor will it be too far away from the surface of the rotary screen 2 to scrape off the solids. When the rotary screen 2 rotates counterclockwise to the scraper 4, the solids adhered to the surface of the rotary screen 2 are scraped by the scraper 4 and slide along the smooth surface of the scraper 4 to the conveyor belt 6, and then discharged through the solid discharge pipe 5; the liquid level in the separation drum 1 is lower than the installation height of the conveyor belt 6, so as to avoid the solid-liquid mixture being directly discharged from the solid discharge pipe 5. During the continuous rotation and scraping process, the solids that are not scraped sink into the water as the rotating screen rotates, and are adsorbed on the rotating screen 2 under the action of suction, and then continue to be scraped by the scraper 4. This reciprocating cycle realizes uninterrupted and continuous solid-liquid separation.

[0025] The second motor 18 drives the water pump 17 to work. The outer water pumping pipe 16 of the water pump 17 is connected to the inner water pumping pipe 14 installed inside the separation drum 1 through the annular tube 15. The annular tube 15 is sleeved on the central shaft 12 and fixed to the outer shell of the separation drum 1 through the bearing sleeve 25. A gap is left between the annular tube 15 and the central shaft 12 to prevent the annular tube 15 from rotating with the central shaft 12, thereby ensuring the safe and stable operation of the inner water pumping pipe 14. Since the inner water pumping pipe 14 is arranged on the separation drum 1, the dense filter screen 3 on the surface of the rotary net 1 plays the role of the first layer of filtering and blocking, which can block large pieces of solid matter outside the rotary net 2. The outer periphery of the water pumping end of the inner water pumping pipe 14 is also sleeved with a filter cover 19 with small retention holes 20, which plays the role of the second layer of filtering and blocking, preventing small pieces of solid matter in the rotary net 2 from entering the inner water pumping pipe 14 through the small retention holes 20 and being extracted with the liquid. At the same time, the setting of the filter cover 19 can also prevent other solid foreign matter from being sucked into the inner water pumping pipe 14, thereby protecting the safe operation of the water pump 17.

[0026] In order to discharge the odor generated during the separation process smoothly, the other end of the central rotating shaft 12 opposite to the annular circular tube 15 is connected to the exhaust pipe of the exhaust pump 22 through a rotary joint 11. The setting of the rotary joint 11 prevents the exhaust pipe from rotating with the central rotating shaft 12, avoids the exhaust pipe from being entangled, and ensures the safe and stable operation of the exhaust pump 22. An eccentric retaining ring 23 is installed inside the exhaust pump 22 through a baffle. The distance between the outer periphery of the eccentric retaining ring 23 and the inner shell of the exhaust pump 22 is different. When the exhaust pump 22 starts working, the inside of the separation drum 1 is in a negative pressure state. The air pressure at the large spacing in the exhaust pump 22 is small, and the air pressure at the small spacing is large. The uneven air pressure in the pump forms a pressure difference, and the atmospheric pressure at the small spacing is squeezed toward the small air pressure at the large spacing, thereby accelerating the discharge of odor in the separation drum 1.

[0027] The present invention separates the solid-liquid mixture in continuous rotation and mixing by arranging a rotating net 2. Solids adhere to the rotating net 2. As the rotating net 2 rotates, they are scraped and discharged by a scraper 4 arranged above a solid discharge pipe 5. The interior of the separation drum 1 is in a negative pressure state. Solids adhere to the rotating net 2 and can be scraped and discharged by the scraper 4 as the rotating net 2 rotates. This reciprocating cycle continuously separates the solid-liquid mixture in the separation drum 1. The separation effect is thorough, and congestion inside the device caused by fixed objects is avoided. The separation drum 1 can be used in a processing system for heparin sodium production.

[0028] The present invention is not limited to the above-mentioned embodiments. On the basis of the technical solutions disclosed in the present invention, those skilled in the art can make some substitutions and modifications to some of the technical features therein according to the disclosed technical content without creative labor, and these substitutions and modifications are all within the protection scope of the present invention.

Claims

1. A solid-liquid separation device for the production of heparin sodium, comprising a base and a separation drum arranged on the base, characterized in that: A first motor is provided on the base on one side of the separation drum, and the output shaft end of the first motor drives the central shaft of the separation drum to rotate via a pulley. A second motor is provided on the base on the other side of the separation drum, and the second motor is connected to a water pump. The outer water pumping pipe of the water pump is connected to the inner water pumping pipe inside the separation drum through an annular circular tube connected to the separation drum; both ends of the central shaft extend to the outside of the separation drum and are fixed to the bearing seats at both ends. The separation drum includes a rotating net that can rotate with the central shaft, and a solid discharge pipe is also provided at a position where the outer shell of the separation drum is flush with the horizontal axis of the central shaft; The annular circular tube is sleeved at one end of the central rotating shaft, a gap is left between the annular circular tube and the central rotating shaft, an external water pumping pipe connected to the water pump and an internal water pumping pipe arranged in the separation drum are connected through the annular circular tube, a bearing sleeve for fixing the annular circular tube is arranged on the separation drum shell where the annular circular tube and the central rotating shaft are connected, and a sealing ring is arranged between the annular circular tube and the separation drum shell; A filter cover with a small interception hole is sleeved on the outer periphery of the water extraction end of the inner water extraction pipe, and a large interception hole is opened on the inner water extraction pipe corresponding to the small interception hole, and the aperture of the large interception hole is larger than the aperture of the small interception hole; A conveyor belt is arranged in the solid discharge pipe, and the conveyor belt is wound around the first roller and the second roller. A scraping blade and a scraper are arranged above the second roller. One end of the scraper is rotatably connected to the scraping blade, and the other end is in contact with a dense filter arranged on the surface of the rotating net. The upper surface of the scraper is a smooth plane. The central rotating shaft is a hollow shaft, and a plurality of through holes are opened on the central rotating shaft. The other end of the central rotating shaft opposite to the annular circular tube is connected to the air extraction component through a rotating joint.

2. A solid-liquid separation device for heparin sodium production according to claim 1, characterized in that: The air extraction component comprises an air extraction pump, an air extraction pipe of the air extraction pump is connected to the rotary joint and communicated with the central rotating shaft, and an eccentric retaining ring is connected to the inside of the air extraction pump through a baffle.

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