The invention relates to the field of medical instruments, and discloses a blood separation comprehensive therapy apparatus complete machine. The blood separation comprehensive therapy apparatus complete machine comprises a rack, wherein the rack is provided with an anti-coagulant pump, a blood pump, a plasma pump, an anti-coagulant hanger, a normal saline hanger, a centrifugal machine, a pipelinedetector, therapeutic apparatus hoops, a plurality of pressure detectors, a plurality of ultrasonic air detectors and a plurality of pinch-off valves; the centrifugal machine is located in the central position of the rack; the blood pump and the pipe detector are arranged beside the centrifugal machine; the anti-coagulant hanger and the normal saline hanger are arranged at two sides of the rack.According to the blood separation comprehensive therapy apparatus complete machine disclosed by the invention, by utilizing the matching of the centrifugal machine and a separation cup in a purification system and adopting a centrifugation technology, blood is separated into blood cells and plasma, a membrane used for separating the blood is replaced, and the production cost is greatly reduced; functional components such as a heater, a cuff connector, an electronic scale, a heat sealing machine and the like are integrated, and medical staff can conveniently operate and use.