Nicotine-free mint tobacco electronic atomization liquid and preparation method thereof

Abstract

The present application relates to a nicotine-free mint tobacco electronic atomization liquid and a preparation method thereof, wherein the atomization liquid comprises the following raw materials in mass parts: 2-5 parts of tobacco extract, 1-3 parts of beet extract, 0.8-1 parts of blueberry extract, 0.5-0.8 parts of hypericin, 1-3 parts of mint coolant, 0.2-0.5 parts of stabilizer, 0.3-0.5 parts of sweetener, 0.5-0.7 parts of flavor blend, 20-30 parts of glycerol, and 25-35 parts of propylene glycol. Preparation of atomization liquid: S1, propylene glycol and glycerol are mixed evenly to obtain a base solvent; S2, the base solvent, tobacco extract, beet extract, blueberry extract, hypericin and mint coolant are mixed evenly at 40-50 ° C to obtain a base mixture; S3, stabilizer, sweetener and flavor blend are added to the base mixture, mixed evenly, and atomization liquid is obtained. The present application has the effect of improving the addiction-relieving property of electronic cigarette atomization liquid.

Description

Technical Field

[0001] The present application relates to the field of electronic cigarettes, and in particular to a nicotine-free mint tobacco electronic atomization liquid and a preparation method thereof. Background Art

[0002] Electronic cigarette oil is an electronic atomizing liquid used with electronic cigarettes. It is heated by the electronic cigarette atomizer to produce cigarette-like mist. The main ingredients of electronic atomizing liquid are nicotine, propylene glycol and tobacco flavors. Since electronic atomizing liquid does not contain harmful substances such as tar and carbon monoxide, it is much less harmful to the human body than ordinary cigarettes, and has become a healthier choice for smokers in modern society.

[0003] Nicotine is often added to existing electronic atomizing liquids to satisfy the addiction relief effect of replacing ordinary cigarettes for smokers. However, nicotine is very harmful to the human body. Therefore, the current market is constantly seeking electronic atomizing liquids with low nicotine or no nicotine content. However, such electronic atomizing liquids are difficult to satisfy smokers' addiction relief and cannot achieve the invigorating effect of ordinary cigarettes.

[0004] In view of the above problems, the inventors believe that providing an electronic atomizing liquid that does not add nicotine but can satisfy the addiction relief needs of smokers has great market and economic value and better meets the needs of modern healthy life. Summary of the invention

[0005] In order to improve the addiction-relieving effect of electronic cigarette atomizer liquid, the present application provides a menthol tobacco electronic atomizer liquid without adding nicotine and a preparation method thereof.

[0006] In the first aspect, the present application provides a menthol tobacco electronic atomization liquid without adding nicotine, which adopts the following technical solution:

[0007] A nicotine-free mint tobacco electronic atomizing liquid comprises the following raw materials in parts by weight:

[0008] 2-5 parts of tobacco extract, 1-3 parts of beet extract, 0.8-1 parts of blueberry extract, 0.5-0.8 parts of hypericin, 1-3 parts of mint coolant, 0.2-0.5 parts of stabilizer, 0.3-0.5 parts of sweetener, 0.5-0.7 parts of flavor blending agent, 20-30 parts of glycerol, and 25-35 parts of propylene glycol.

[0009] Preferably, the electronic atomization liquid includes the following raw materials in parts by mass: 3 parts of tobacco extract, 3 parts of beet extract, 1 part of blueberry extract, 0.6 parts of hypericin, 1.8 parts of mint coolant, 0.4 parts of stabilizer, 0.4 parts of sweetener, 0.6 parts of flavor blending agent, 23 parts of glycerol, and 32 parts of propylene glycol.

[0010] Nicotine can stimulate the cerebral cortex, promote the secretion of dopamine, and put the brain in an excited state, making people feel relaxed and happy. However, as the dopamine content in the body surges and then rapidly metabolizes and decreases, this stimulation dissipates, causing a huge sense of gap in smokers. Smokers will feel uncomfortable all over, which in turn increases their need for nicotine stimulation, thus leading to dependence on tobacco.

[0011] In the present application, by adopting the above-mentioned technical scheme, the mint coolant determines the refreshing tone of the prepared electronic atomization liquid; the tobacco extract, beet extract, blueberry extract and hypericin are compounded, and the prepared electronic atomization liquid can promote the body's dopamine secretion without adding nicotine during the smoking process, and make the secreted dopamine metabolized slowly. The secretion and metabolism process of dopamine is smooth and stable, which can bring a long-lasting and stable sense of refreshing and relaxation to the smoker, meet the needs of smoking addiction, and reduce the smoker's desire to smoke in a short time; and the stabilizer, sweetener and flavor blend work together, so that the prepared atomization liquid will not be too cold and bitter under the tone of tobacco mint, and the taste is dense and the flavor is good.

[0012] Preferably, the mint coolant comprises 30-40%wt of menthol, 20-30%wt of menthyl lactate and the balance of peppermint oil.

[0013] By adopting the above technical scheme, the mint coolant prepared by compounding menthol, menthyl lactate and peppermint oil has the cooling and refreshing effect of mint, and the cooling feeling lasts for a long time. It can achieve a good compatible and coordinated effect with the extract components in the atomized liquid, thereby laying the cooling tone of the atomized liquid and further enhancing the effect of promoting dopamine secretion.

[0014] Preferably, the stabilizer includes two or more of xanthan gum, pullulan and ethyl maltol.

[0015] By adopting the above technical scheme, xanthan gum, pullulan and ethyl maltol are added to the atomizing liquid as stabilizers alone or in combination, which can effectively connect the various components in the atomizing liquid, improve the stability of the overall atomizing liquid system, and thus improve the quality of the prepared electronic atomizing liquid product.

[0016] Preferably, the stabilizer is obtained by mixing xanthan gum, pullulan, ethyl maltol and water in a mass ratio of (1-2):(0.3-0.5):2:5.

[0017] By adopting the above technical scheme, water is used as the solvent, and xanthan gum, pullulan and ethyl maltol are dissolved and compounded in water according to a specific ratio. Under the joint action, the stability of the overall system of the atomized liquid can be further improved, and the coordination between the components in the atomized liquid system can be further promoted, so that the addiction relief obtained after inhaling the atomized liquid is satisfactory and lasting.

[0018] Preferably, the flavor blend is prepared by mixing dihydroactin, γ-dodecalactone, vanillin and propylene glycol in a mass ratio of 3:2:1.8:5.

[0019] By adopting the above technical scheme, with propylene glycol as the solvent, dihydroactinolactone, γ-dodecalactone and vanillin are compounded and prepared in a specific proportion to obtain a flavor blend that can neutralize the overly cold stimulation brought by the mint coolant, and give the atomized liquid a light and dense feeling during the inhalation process, without an overly prominent flavor, and is therefore more universal and suitable for the flavor needs of most consumers.

[0020] Preferably, the sweetener is neotame or aspartame.

[0021] By adopting the above technical scheme, neotame and aspartame have low calories, high sweetness, pure sweetness, freshness and naturalness, good stability, can achieve good compatibility with the components in the atomized liquid system, and prolong and enhance the taste and aroma of the atomized liquid prepared by the present application.

[0022] In the second aspect, the present application provides a method for preparing a nicotine-free mint tobacco electronic atomization liquid using the following technical solution:

[0023] A method for preparing a nicotine-free mint tobacco electronic atomization liquid comprises the following steps:

[0024] S1, mixing propylene glycol and glycerol evenly to obtain a base solvent;

[0025] S2, heating the base solvent to 40-50° C., adding tobacco extract, beet extract, blueberry extract, hypericin and mint coolant, and mixing evenly to obtain a base mixture;

[0026] S3, adding the stabilizer, sweetener and flavor blend into the base mixture, stirring until completely dissolved, and obtaining a mint tobacco electronic atomization liquid without adding nicotine.

[0027] By adopting the above technical solution, the main ingredients such as tobacco extract are first added to facilitate the full mixing of the extracts, and then additives such as stabilizers are added to further adjust the overall stability of the atomized liquid system, so that the atomized liquid has uniform components, stable performance, and a long-lasting flavor.

[0028] In summary, the present application includes at least one of the following beneficial technical effects:

[0029] 1. The present application uses tobacco extract, beet extract, blueberry extract, and hypericin as the compound components. During the smoking process, the prepared electronic atomized liquid can promote the secretion of dopamine in the human body by the same effect as nicotine, and the secreted dopamine can be kept stable in the body for a long period of time, reducing the sense of difference caused by the sudden increase and decrease of dopamine secretion, thereby bringing the trial user a long-term and stable refreshing and relaxing effect, and satisfying the user's purpose of smoking addiction without damaging the user's health; the above components are combined with mint coolant, stabilizer, sweetener, and flavor blending agent to work together, so that the prepared atomized liquid will not be too cold under the basic tone of tobacco mint, and the taste is dense and the flavor is good;

[0030] 2. The mint coolant in the present application is prepared by compounding menthol, menthyl lactate and peppermint oil, and has the cooling and refreshing effect of mint, and the cooling feeling lasts for a long time. The addition of the mint coolant can further amplify the stimulating effect of the atomized liquid on dopamine secretion, so that the user can relieve fatigue and feel happy after inhaling the atomized liquid;

[0031] 3. The present application uses water as a solvent, and dissolves xanthan gum, pullulan, and ethyl maltol in water in a specific ratio to prepare a stabilizer. The stabilizer is added to the atomized liquid, and the components in the stabilizer can work together to further enhance the stability of the overall atomized liquid system and promote the coordination between the components in the atomized liquid system, so that the addiction relief obtained after inhaling the atomized liquid is satisfying and lasting. DETAILED DESCRIPTION

[0032] The present application is further described in detail below in conjunction with embodiments and comparative examples.

[0033] Preparation Example

[0034] Preparation Example 1

[0035] Preparation Example 1 discloses a method for preparing a mint coolant, specifically: 3 g of menthol, 3 g of menthyl lactate and 4 g of peppermint oil are mixed and added into a blender, and stirred at a speed of 800 r / min for 3 min to obtain a mint coolant.

[0036] Preparation Example 2

[0037] Preparation Example 2 discloses a method for preparing a mint coolant, specifically: 4 g of menthol, 2 g of menthyl lactate and 4 g of peppermint oil are mixed and added into a blender, and stirred at a speed of 800 r / min for 3 min to obtain a mint coolant.

[0038] Preparation Example 3

[0039] Preparation Example 3 discloses a method for preparing a mint coolant, specifically: 2.5 g of menthol, 3.5 g of menthyl lactate and 4 g of peppermint oil are mixed and added into a blender, and stirred at a speed of 800 r / min for 3 min to obtain a mint coolant.

[0040] Preparation Example 4

[0041] Preparation Example 4 discloses a method for preparing a stabilizer, specifically: 1.59 g of xanthan gum and 0.48 g of pullulan are mixed and added into 7.93 g of water, heated to 35° C., and stirred at a speed of 100 r / min for 10 min to obtain a stabilizer.

[0042] Preparation Example 5

[0043] Preparation Example 5 discloses a method for preparing a stabilizer, specifically: 0.67 g of pullulan and 2.67 g of ethyl maltol are mixed and added into 6.66 g of water, heated to 35° C., and stirred at a speed of 100 r / min for 10 min to obtain a stabilizer.

[0044] Preparation Example 6

[0045] Preparation Example 6 discloses a method for preparing a stabilizer, specifically: mix 1g of xanthan gum, 1g of pullulan and 1g of ethyl maltol, add them to 7g of water, heat to 35°C, and stir at a speed of 100r / min for 10min to obtain a stabilizer, wherein the mass ratio of xanthan gum, pullulan, ethyl maltol and water is 1:1:1:7.

[0046] Preparation Example 7

[0047] Preparation Example 7 discloses a method for preparing a stabilizer, specifically: 1.2 g of xanthan gum, 0.36 g of pullulan and 2.41 g of ethyl maltol are mixed and added to 6.02 g of water, heated to 35°C, and stirred at a speed of 100 r / min for 10 minutes to obtain a stabilizer, wherein the mass ratio of xanthan gum, pullulan, ethyl maltol and water is 1:0.3:2:5.

[0048] Preparation Example 8

[0049] Preparation Example 8 discloses a method for preparing a stabilizer, specifically: 2.11 g of xanthan gum, 0.53 g of pullulan and 2.11 g of ethyl maltol are mixed and added to 5.25 g of water, heated to 35°C, and stirred at a speed of 100 r / min for 10 minutes to obtain a stabilizer, wherein the mass ratio of xanthan gum, pullulan, ethyl maltol and water is 2:0.5:2:5.

[0050] Preparation Example 9

[0051] Preparation Example 9 discloses a method for preparing a flavor blend, specifically: 2.54 g of dihydroactin, 1.69 g of γ-dodecalactone, 1.53 g of vanillin and 4.24 g of propylene glycol are mixed, and stirred at a speed of 100 r / min for 10 min to obtain the flavor blend.

[0052] Example

[0053] Examples 1-4

[0054] Example 1-4 discloses a menthol tobacco electronic atomization liquid without adding nicotine, comprising the following raw materials in parts by weight:

[0055] 2-5 parts of tobacco extract, 1-3 parts of beet extract, 0.8-1 parts of blueberry extract, 0.5-0.8 parts of hypericin, 1-3 parts of mint coolant, 0.2-0.5 parts of stabilizer, 0.3-0.5 parts of sweetener, 0.5-0.7 parts of flavor blending agent, 20-30 parts of propylene glycol, and 25-35 parts of glycerol.

[0056] Examples 1-4 also disclose a method for preparing the above-mentioned nicotine-free mint tobacco electronic atomization liquid, comprising the following steps:

[0057] S1, mixing propylene glycol and glycerol, and stirring at a speed of 70 r / min for 1 min to obtain a base solvent;

[0058] S2, heating the matrix solvent to 40-50° C., adding tobacco extract, beet extract, blueberry extract, hypericin and mint coolant, stirring at a speed of 1000 r / min for 5 min to obtain a matrix mixture;

[0059] S3. Add the stabilizer, sweetener and flavor blend into the base mixture, stir at a speed of 1000 r / min for 5 minutes, and obtain a mint tobacco electronic atomization liquid without adding nicotine.

[0060] The dosages of the raw material components in Examples 1-4 (unit: g) are detailed in Table 1.

[0061] Table 1

[0062]

[0063]

[0064] Embodiment 5-6

[0065] Examples 5-6 disclose a method for preparing a nicotine-free mint tobacco electronic atomization liquid, which is different from Example 4 in that the stabilizers are the stabilizers prepared in Preparation Examples 7 and 8, respectively.

[0066] Comparative Example

[0067] Comparative Example 1

[0068] Comparative Example 1 discloses a method for preparing a menthol tobacco electronic atomization liquid without adding nicotine, which is different from Example 4 in that the beet extract is replaced with an equal amount of propylene glycol.

[0069] Comparative Example 2

[0070] Comparative Example 2 discloses a method for preparing a menthol tobacco electronic atomization liquid without adding nicotine, which is different from Example 4 in that the blueberry extract is replaced with an equal amount of propylene glycol.

[0071] Comparative Example 3

[0072] Comparative Example 3 discloses a method for preparing a menthol tobacco electronic atomization liquid without adding nicotine, which is different from Example 4 in that: hypericin is replaced by an equal amount of propylene glycol.

[0073] Comparative Example 4

[0074] Comparative Example 4 discloses a method for preparing a mint tobacco electronic atomization liquid without adding nicotine, which is different from Example 4 in that the menthyl lactate and peppermint oil in the mint coolant are replaced with an equal amount of menthol.

[0075] Comparative Example 5

[0076] Comparative Example 5 discloses a method for preparing a menthol tobacco electronic atomization liquid without adding nicotine, which is different from Example 4 in that the stabilizer is replaced with an equal amount of propylene glycol.

[0077] Performance testing

[0078] Experiment 1: Dopamine secretion detection:

[0079] 33 mice weighing about 200 g were selected. The mice were in good health. The mice were divided into 11 groups. 3 mice in each group were placed in 3 transparent sealed boxes for culture. Oxygen was introduced into the boxes. The living environment and culture method of each group were the same. Each group tested the sample prepared in the same embodiment or comparative example. Before the test, the dopamine content in the blood of the mice in each box was detected as a blank control. Then, smoke formed by the same sample was introduced into each of the three transparent boxes by an atomizer. The amount introduced into each box was 1 ml, and the ventilation time was 1 min. The dopamine content in the blood of the mice in the three boxes was detected at 5 min, 30 min, and 2 h after inhaling the smoke, and the increase in dopamine content was calculated, and the increase = (dopamine content after inhaling the smoke for a limited time - dopamine content before the test) / dopamine content before the test × 100%;

[0080] The dopamine content was tested by high performance liquid chromatography, where the chromatographic conditions were as follows: chromatographic column: Develosil C30-UG-5 (150×4.6mm, 5μm, Nomura Chemical, Japan Co., Ltd); mobile phase: potassium dihydrogen phosphate solution (25mmol / L, containing 0.5mmol / L disodium ethylenediaminetetraacetic acid, 0.5mmol / L sodium octane sulfonate, adjusted to pH=3.6 with phosphoric acid): acetonitrile = 90:10 (volume ratio), vacuum filtered through a 0.45μm filter membrane before use, flow rate 1.0mL / min; glassy carbon working electrode, Ag / AgCl reference electrode, detection potential 0.6V; column temperature 30℃, automatic sampler temperature 10℃; experimental method: SD mice were anesthetized, blood was collected from the orbital venous plexus, allowed to stand, centrifuged to separate serum, 250μL serum was drawn into a centrifuge tube, 250μL of 2% trichloroacetic acid solution (precooled to 4℃) was added, vortexed for 30s, allowed to stand for 30min, low-temperature high-speed centrifugation (4℃, 15000r / min, 15min), and 50μL of the supernatant was taken for injection and determination.

[0081] Experiment 2, addiction test:

[0082] 10 testers were selected to respectively smoke the electronic atomization liquids prepared in the embodiments of the present application and the comparative examples. Each tester was required to test only one experimental sample per day. The smoking test was started in the evening (17:00-19:00) when the human body is most tired, and each puff was separated by 1 minute. The number of puffs taken when the tester felt satisfied with the addiction was recorded, and the average value of the test results of each experimental sample was taken.

[0083] Experiment 3: Sensory performance evaluation:

[0084] 110 male smokers aged between 25 and 45 were selected and randomly divided into 11 groups, with 10 people in each group. The electronic atomization liquids prepared in the embodiments of the present application and the comparative examples were smoked using electronic cigarettes, and the cooling feeling, sweetness, restoration feeling, smoke volume, miscellaneous taste, aftertaste and addiction relief of the samples after use were scored and evaluated. The scores were from 0 to 10 points from bad to good, and the results were averaged.

[0085] The performance test data of Experiments 1-3 are detailed in Table 2-3.

[0086] Table 2

[0087]

[0088]

[0089] Table 3

[0090] Cooling sensation Sweetness Restoration Off-flavor Aftertaste Smoke volume Addiction Example 1 8 7 7 9 9 8 9 Example 2 8 8 7 10 9 9 9 Example 3 8 7 7 10 9 9 10 Example 4 8 8 7 10 10 9 10 Example 5 8 8 8 10 10 10 10 Example 6 9 8 7 10 10 10 10 Comparative Example 1 7 5 6 9 6 7 5 Comparative Example 2 8 6 6 9 5 8 4 Comparative Example 3 7 7 6 8 4 8 5 Comparative Example 4 10 6 5 9 3 7 7 Comparative Example 5 8 7 6 9 6 7 6

[0091] According to the performance test data of Examples 1-4 in Table 2, the atomized liquid prepared in Examples 1-4 of the present application can significantly promote the secretion of dopamine and maintain the stability of the dopamine content in the body for a long period of time. Taking 3-5 puffs can achieve the physiological satisfaction of addiction relief, with a dense and prolonged taste and a sweet flavor, which can relax the mind of the smoker and make him feel happy physically and mentally.

[0092] Examples 5 and 6 use the stabilizers prepared in Preparation Examples 7 and 8. Preparation Examples 7 and 8 further limit the combination ratio of the components in the stabilizer, thereby further improving the stabilizing effect of the stabilizer, so that the electronic atomization liquid prepared in Examples 5 and 6 has a longer-lasting dopamine secretion stabilization effect and a stronger anti-addiction effect than the electronic atomization liquid prepared in Example 4.

[0093] In Comparative Examples 1-3, beet extract, blueberry extract and hypericin are replaced with an equal amount of propylene glycol solvent, respectively. The atomized liquid systems prepared in Comparative Examples 1-3 lack beet extract, blueberry extract and hypericin, respectively. In the present application, the combinations of tobacco extract, beet extract, blueberry extract and hypericin have a special synergistic effect, which can promote the secretion of dopamine in the body under synergistic cooperation, and control the rate of dopamine secretion and metabolism, so that the smoker can be refreshed and feel physically and mentally happy during the slow secretion of dopamine; and the lack of one or more of the above components breaks the synergistic inhibition balance between the components, thereby reducing the increase in dopamine in the atomized liquid prepared in Comparative Examples 1-3, shortening the maintenance time of dopamine in the body, and reducing the addiction-relieving effect.

[0094] In Comparative Example 4, the menthyl lactate and peppermint oil in the mint coolant are replaced with an equal amount of menthol. The mint coolant in the present application can effectively neutralize the cool and bitter feeling of mint through the compounding of multiple components, thereby increasing the integration of the mint cool feeling with other fragrances and sweetness and the persistence of the sweet taste of the atomized liquid, so that the flavor and taste of the prepared atomized liquid are better. In Comparative Example 4, a single component of menthol is used as a coolant, and the cool feeling is too prominent, and it will have a bitter feeling. Under the short-term cool stimulation, multiple inhalations are required to make up for the quickly dissipated satisfaction, thereby significantly reducing the addiction relief of the atomized liquid prepared in Comparative Example 4.

[0095] In Comparative Example 5, the stabilizer is replaced with an equal amount of propylene glycol. The xanthan gum, pullulan and ethyl maltol in the stabilizer are compounded in water and added to the atomized liquid to improve the stability of the overall system of the atomized liquid and promote the coordination between the components in the atomized liquid system, so that the addiction relief obtained after inhaling the atomized liquid is satisfactory and lasting. The lack of stabilizer makes the atomized liquid prepared in Comparative Example 5 less stable and less addictive than the atomized liquid prepared in Example 4 in stimulating dopamine secretion and dopamine retention in the body.

[0096] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A nicotine-free mint tobacco electronic atomization liquid, characterized in that: The invention comprises the following raw materials in parts by weight: 2-5 parts of tobacco extract, 1-3 parts of beet extract, 0.8-1 parts of blueberry extract, 0.5-0.8 parts of hypericin, 1-3 parts of mint coolant, 0.2-0.5 parts of stabilizer, 0.3-0.5 parts of sweetener, 0.5-0.7 parts of flavor blending agent, 20-30 parts of glycerol, 25-35 parts of propylene glycol; The stabilizer is obtained by mixing xanthan gum, pullulan, ethyl maltol and water in a mass ratio of (1-2): (0.3-0.5): 2:5; The flavor blend is prepared by mixing dihydroactin, gamma-dodecalactone, vanillin and propylene glycol in a mass ratio of 3:2:1.8:

5.

2. The nicotine-free mint tobacco electronic atomization liquid according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 3 parts of tobacco extract, 3 parts of beet extract, 1 part of blueberry extract, 0.6 parts of hypericin, 1.8 parts of mint coolant, 0.4 parts of stabilizer, 0.4 parts of sweetener, 0.6 parts of flavor blender, 23 parts of glycerol, and 32 parts of propylene glycol.

3. The nicotine-free mint tobacco electronic atomization liquid according to claim 1 or 2, characterized in that: The mint coolant comprises 30-40%wt of menthol, 20-30%wt of menthyl lactate and the balance of peppermint oil.

4. The nicotine-free mint tobacco electronic atomization liquid according to claim 1 or 2, characterized in that: The sweetener is neotame or aspartame.

5. A method for preparing a nicotine-free mint tobacco electronic atomization liquid according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1, mixing propylene glycol and glycerol evenly to obtain a base solvent; S2, heating the base solvent to 40-50° C., adding tobacco extract, beet extract, blueberry extract, hypericin and mint coolant, and mixing evenly to obtain a base mixture; S3, adding the stabilizer, sweetener and flavor blend into the base mixture, stirring until completely dissolved, and obtaining a mint tobacco electronic atomization liquid without adding nicotine.

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