A kind of quick-dissolving hyaluronate and preparation method thereof

Abstract

The present application provides a method for preparing a fast-dissolving hyaluronate, wherein the fast-dissolving hyaluronate is prepared using hyaluronate and a binder as raw materials, wherein the binder is selected from one or more of monosaccharides, disaccharides, oligosaccharides, sugar alcohols, and soluble dietary fibers. The preparation method of the present application can solve the problems of dust pollution and slow dissolution rate during the use of hyaluronate. The preparation method of the present application granulates the hyaluronate to prevent the generation of small particles of dust, and can be quickly dispersed and dissolved in a liquid, thereby saving time and cost. In addition, the preparation method of the present application does not use an organic solvent and is safer.

Description

Technical Field

[0001] The present application belongs to the field of biomedicine, and specifically relates to a fast-dissolving hyaluronate and a preparation method thereof. Background Art

[0002] Hyaluronic acid is a macromolecular acidic mucopolysaccharide composed of D-glucuronic acid and N-acetylglucosamine disaccharide units, also known as hyaluronic acid. With its unique molecular structure and physical and chemical properties, hyaluronic acid exhibits a variety of important physiological functions in the body and is used in the fields of medicine and food. The slow solubility of hyaluronic acid in aqueous solution is the main factor affecting its application in different dosage forms. There are many methods for preparing instant hyaluronic acid on the market, such as using spray drying to obtain fine powder, using hammer mills and ultrafine mills to crush to obtain instant hyaluronic acid powder, and using granulators to make hyaluronic acid particles with three-dimensional structures.

[0003] Patent No. CN110423291 B describes a method for preparing a quick-dissolving sodium hyaluronate. After a sodium hyaluronate solution is framed with low-molecular sodium hyaluronate or chitosan, an organic solvent is added and freeze-dried to obtain quick-dissolving sodium hyaluronate, which completely dissolves in 4 minutes. However, the concentration of high-molecular sodium hyaluronate obtained by this method is only 0.5%, and a large amount of small-molecular sodium hyaluronate or chitosan needs to be introduced into the end product. In addition, the dissolution time is far from meeting the needs of the end product. Summary of the invention

[0004] In view of the above problems existing in the prior art, the present application provides a fast-dissolving hyaluronate and a preparation method thereof.

[0005] Specifically, this application involves the following aspects:

[0006] 1. A method for preparing a fast-soluble hyaluronate, characterized in that the fast-soluble hyaluronate is prepared by a boiling granulation method, and the raw materials used include a hyaluronate raw material and a binder, and the binder is selected from one or more of monosaccharides, disaccharides, oligosaccharides, sugar alcohols, and soluble dietary fibers.

[0007] 2. The preparation method according to item 1, characterized in that it comprises the following steps:

[0008] After the hyaluronate raw material is suspended in an air stream, a binder solution is sprayed on it to prepare hyaluronate particles, and the hyaluronate particles are dried and sieved to obtain instant hyaluronate.

[0009] 3. The preparation method according to item 2 is characterized in that the binder solution is an aqueous solution of the binder, wherein the concentration of the binder is 0.1wt%-60wt%.

[0010] 4. The preparation method according to item 2 or 3 is characterized in that the mass ratio of the added amount of the adhesive solution to the hyaluronate raw material is (0.1-20):1.

[0011] 5. The preparation method according to item 2 is characterized in that after the hyaluronate raw material is suspended in air flow and before the adhesive solution is sprayed, the following steps are further included:

[0012] spraying water or an aqueous solution to prepare first hyaluronate particles,

[0013] The first hyaluronate particles are dried.

[0014] 6. The preparation method according to item 5 is characterized in that the mass ratio of the added amount of water or aqueous solution to the hyaluronate raw material is (0.1-10):1.

[0015] 7. The preparation method according to item 1, characterized in that it comprises the following steps:

[0016] The hyaluronate raw material is mixed with the adhesive and then suspended in an air stream, and then sprayed with water or an aqueous solution to prepare hyaluronate particles. The hyaluronate particles are dried and sieved to obtain instant hyaluronate.

[0017] 8. The preparation method according to item 7 is characterized in that the mass ratio of the hyaluronate raw material to the adhesive is (2-99):1.

[0018] 9. The preparation method according to item 7 or 8 is characterized in that the mass ratio of water or aqueous solution to the mixture of the hyaluronate raw material and the adhesive is (0.1-20):1.

[0019] 10. A fast-dissolving hyaluronate, prepared by the preparation method described in any one of items 1 to 9.

[0020] The preparation method of the present application can solve the problems of dust pollution and slow dissolution rate during the use of hyaluronate. The preparation method of the present application granulates the hyaluronate to prevent the generation of small particles of dust, and can be quickly dispersed and dissolved in liquid, thereby saving time and cost. In addition, the preparation method of the present application does not use organic solvents, and is safer to eat. DETAILED DESCRIPTION

[0021] The present application is further described below in conjunction with examples. It should be understood that the examples are only used to further describe and illustrate the present application and are not used to limit the present application.

[0022] Unless otherwise defined, the technical and scientific terms in this specification have the same meaning as those generally understood by those skilled in the art. Although similar or identical methods and materials as described herein may be used in experiments or practical applications, materials and methods are described herein below. In the event of a conflict, the present specification including the definitions therein shall prevail. In addition, materials, methods and examples are provided for illustration only and are not restrictive. The present application is further described below in conjunction with specific embodiments, but is not intended to limit the scope of the present application.

[0023] The present application provides a method for preparing instant hyaluronate, which adopts a boiling granulation method to prepare instant hyaluronate, and the raw materials used include hyaluronate raw materials and a binder, and the binder is selected from one or more of monosaccharides, disaccharides, oligosaccharides, sugar alcohols, and soluble dietary fibers.

[0024] Fluidized bed granulation is a commonly used granulation method in the art, which is to put the material into a closed container, suspend the material in the container by air flow, spray the binder at a uniform speed through the equipment, let the binder and the material mix fully, flow in the container to form small particles, send hot air through the bottom, dry the wet particles, and finally directly collect the finished dry particles. For the specific method of fluidized bed granulation, those skilled in the art can make their own choices in the prior art, and this application does not limit it.

[0025] Monosaccharides refer to molecules that cannot be simply hydrolyzed into smaller sugars. According to the position of the carbonyl group, they are divided into two categories: aldoses and ketoses. According to the number of carbon atoms in the monosaccharide, it can also be divided into trioses, tetroses, pentoses, hexoses, and heptoses. The most abundant monosaccharides in nature are pentoses and hexoses. Such as glyceraldehyde, a three-carbon sugar; erythrose and thulose, four-carbon sugars; arabinose, ribose, xylose, and lyxose, five-carbon sugars; glucose, mannose, fructose, and galactose, six-carbon sugars. Monosaccharides in food are mainly hexoses (six-carbon sugars).

[0026] In a specific embodiment, the monosaccharide is selected from one or more of glucose, fructose, galactose and arabinose.

[0027] Disaccharides, also known as disaccharides, are formed by two molecules of monosaccharides through glycosidic bonds. When the reducing group of one monosaccharide is combined with the alcoholic hydroxyl group of another sugar, they show the common chemical properties with monosaccharides, such as reduction in Fehling solution, mutarotation, and amine formation (such as maltose and lactose). Monosaccharides combined through reducing groups do not have this property (such as sucrose and trehalose).

[0028] In a specific embodiment, the disaccharide is selected from one or more of white sugar, lactose, maltose and trehalose.

[0029] Oligosaccharides, also known as oligosaccharides or oligosaccharides, are a new type of functional sugar source. They usually refer to compounds containing 2-10 glycosidic bonds. The glycosidic bond is formed by the dehydration condensation of the glycoside hydroxyl group of a monosaccharide and a hydroxyl group of another monosaccharide.

[0030] In a specific embodiment, the oligosaccharide is selected from one or more of fructooligosaccharide, maltooligosaccharide, isomaltooligosaccharide, lactofructooligosaccharide and chitosan oligosaccharide.

[0031] Sugar alcohol is a polyol containing more than two hydroxyl groups. However, unlike polyols such as ethylene glycol, propylene glycol, and pentaerythritol synthesized from petrochemicals, sugar alcohol can be prepared from widely available corresponding sugars, that is, the aldehyde or ketone groups on the sugar molecules are reduced to hydroxyl groups to form sugar alcohols. For example, glucose is reduced to form sorbitol, xylose is reduced to form xylitol, maltose is reduced to form maltitol, and fructose is reduced to form mannitol.

[0032] In a specific embodiment, the sugar alcohol is selected from one or more of erythritol, xylitol, maltitol, sorbitol, lactitol and mannitol.

[0033] Dietary fiber is a type of carbohydrate that cannot be digested by the human body. It is divided into two categories: soluble fiber and insoluble fiber. Common pectin and gum are soluble fibers, which exist in non-fibrous substances in nature.

[0034] In a specific embodiment, the soluble dietary fiber is selected from one or more of resistant dextrin, polydextrose and inulin.

[0035] In a specific embodiment, the binder is erythritol.

[0036] In a specific embodiment, the binder is resistant dextrin.

[0037] In a specific embodiment, the binder is white sugar.

[0038] In a specific embodiment, the binder is erythritol.

[0039] In a specific embodiment, the binder is fructose.

[0040] In a specific embodiment, the preparation method described in the present application comprises the following steps:

[0041] After the hyaluronate raw material is suspended in an air stream, a binder solution is sprayed on it to prepare hyaluronate particles, and the hyaluronate particles are dried and sieved to obtain instant hyaluronate.

[0042] The purpose of using air flow suspension is to keep the hyaluronate raw material in a fluidized state and fully disperse it. The process parameters and implementation methods related to air flow suspension can be carried out in a conventional manner in the art. In this application, the air flow used for air flow suspension is clean air. The air volume, air pressure and other parameters of the air flow are not limited and can be adjusted accordingly according to the amount of material.

[0043] In a specific embodiment, the temperature of the air flow in the air flow suspension is 30-60°C.

[0044] The adhesive solution may be sprayed in any manner that is conducive to uniform distribution of the adhesive solution, and this application does not impose any limitation thereto, and those skilled in the art may select one from the prior art.

[0045] In a specific embodiment, the binder solution is sprayed in the form of a mist aqueous solution, and the compressed air pressure is 0.3-0.6 MPa.

[0046] After spraying the adhesive, the hyaluronate raw material can form uniformly dispersed hyaluronate particles.

[0047] In a specific embodiment, the hyaluronate particles have a uniform particle size, with a particle size of 5-60, preferably 30-40 mesh.

[0048] The binder solution is an aqueous solution of a binder. In a specific embodiment, the concentration of the binder in the binder solution is 0.1wt%-60wt%, for example, 0.1wt%, 0.5wt%, 1wt%, 5wt%, 10wt%, 15wt%, 20wt%, 25wt%, 30wt%, 35wt%, 40wt%, 45wt%, 50wt%, 55wt%, 60wt%, etc.

[0049] In a specific embodiment, the mass ratio of the added amount of the adhesive solution to the hyaluronate raw material is (0.1-20):1, for example, it can be 0.1:1, 0.2:1, 0.5:1, 0.7:1, 1:1, 3:1, 5:1, 10:1, 12:1, 15:1, 18:1, 20:1, etc.

[0050] In a specific embodiment, after the hyaluronate raw material is suspended in air flow and before the adhesive solution is sprayed, the following steps are further included:

[0051] spraying water or an aqueous solution to prepare first hyaluronate particles,

[0052] The first hyaluronate particles are dried.

[0053] In this case, the preparation method of the present application comprises the following steps:

[0054] After the hyaluronate raw material is suspended in air flow, water or an aqueous solution is sprayed to prepare first hyaluronate particles, and the first hyaluronate particles are dried.

[0055] The binder solution is sprayed onto the first hyaluronate particles to prepare hyaluronate particles, and the hyaluronate particles are dried and sieved to obtain fast-dissolving hyaluronate.

[0056] The aqueous solution can be an aqueous solution of various components, for example, a hyaluronate aqueous solution. The concentration of hyaluronate in the hyaluronate aqueous solution is not limited in this application, as long as the hyaluronate aqueous solution is kept in a flowing state, and those skilled in the art can freely choose, for example, 0.1wt%-15wt%, preferably 0.1wt%-5wt%, for example, 0.1wt%, 0.2wt%, 0.2wt%, 0.7wt%, 1.0wt%, 1.5wt%, 2.0wt%, 2.5wt%, 3.0wt%, 5wt%, 10wt%, 15wt%, etc.

[0057] The present application does not impose any limitation on the molecular weight of the hyaluronate in the aqueous solution of hyaluronate.

[0058] In a specific embodiment, the molecular weight of the hyaluronate in the aqueous solution of hyaluronate is 1-2 million, for example, 10,000, 50,000, 100,000, 200,000, 300,000, 400,000, 500,000, 600,000, 700,000, 800,000, 900,000, 1 million, 1.1 million, 1.2 million, 1.3 million, 1.4 million, 1.5 million, 1.6 million, 1.7 million, 1.8 million, 1.9 million, 2 million, etc.

[0059] The mass ratio of the added amount of water or aqueous solution to the hyaluronate raw material is (0.1-10):1, for example, it can be 0.1:1, 0.2:1, 0.5:1, 0.7:1, 1:1, 3:1, 5:1, 10:1, etc.

[0060] In a specific embodiment, the first hyaluronate particles are passed through a 30-80 mesh sieve, preferably a 40-60 mesh sieve, and the obtained first hyaluronate particles are uniform particles with a particle size of 30-80 mesh, preferably 40-60 mesh.

[0061] The adhesive of the present application can also be first dry-mixed with the hyaluronate raw material and then granulated.

[0062] In a specific embodiment, the preparation method described in the present application comprises the following steps:

[0063] The hyaluronate raw material is mixed with a binder and then suspended in an air stream, and then sprayed with water or an aqueous solution to prepare hyaluronate particles. The hyaluronate particles are dried and sieved to obtain instant hyaluronate.

[0064] The aqueous solution is as described above, and may be an aqueous solution of various components, for example, an aqueous solution of hyaluronate.

[0065] In a specific embodiment, the mass ratio of the hyaluronate raw material to the adhesive is 2-99:1, for example, it can be 2:1, 5:1, 10:1, 15:1, 20:1, 25:1, 30:1, 35:1, 40:1, 45:1, 50:1, 55:1, 60:1, 65:1, 70:1, 75:1, 80:1, 85:1, 90:1, 95:1, 99:1, etc.

[0066] In a specific embodiment, the mass ratio of the aqueous solution to the mixture of the hyaluronate raw material and the binder is (0.1-20):1, that is, the ratio of the mass of the aqueous solution to the mass of the hyaluronate raw material and the binder is (0.1-20):1. For example, it can be 0.1:1, 0.2:1, 0.5:1, 0.7:1, 1:1, 3:1, 5:1, 10:1, 12:1, 15:1, 18:1, 20:1, etc.

[0067] In a specific embodiment, the mass ratio of water to the mixture of the hyaluronate raw material and the binder is (0.1-20): 1,

[0068] This application does not limit the molecular weight of the hyaluronate contained in the raw materials.

[0069] In a specific embodiment, the molecular weight of the hyaluronate raw material used in the present application is 400,000 or more, preferably 400,000-2 million, for example, it can be 400,000, 500,000, 600,000, 700,000, 800,000, 900,000, 1 million, 1.1 million, 1.2 million, 1.3 million, 1.4 million, 1.5 million, 1.6 million, 1.7 million, 1.8 million, 1.9 million, 2 million, etc.

[0070] In the present application, the hyaluronate in the hyaluronate raw material or the hyaluronate aqueous solution may be sodium hyaluronate, potassium hyaluronate, zinc hyaluronate, etc., preferably sodium hyaluronate.

[0071] The present application also provides a fast-dissolving hyaluronate prepared by any one of the above-mentioned preparation methods.

[0072] Example

[0073] The present application provides a general and / or specific description of the materials and test methods used in the experiments. In the following examples, unless otherwise specified, % means wt%, i.e., weight percentage. The reagents or instruments used without indicating the manufacturer are all conventional reagent products that can be obtained commercially.

[0074] Example 1

[0075] 1. Step 1: Prepare a certain mass of sodium hyaluronate raw material (purchased from Bloomage Biotechnology Co., Ltd., batch number 1803234, molecular weight 1.37 million Da), use appropriate air volume under the fluidization state of the material, and the air flow temperature is 50°C. Spray mist water, the compressed air pressure is 0.6MPa, and the mass ratio of water spray to sodium hyaluronate raw material is 0.67:1. After completion, dry at 50°C, pass through a 40-60 mesh sieve, and obtain the first hyaluronate particles, whose particle size is 40-60 mesh.

[0076] 2. Step 2: Use appropriate air volume while ensuring the fluidization of the material, and the air temperature is 50°C. Spray a 5% oligofructose aqueous solution into the first hyaluronate particles, the compressed air pressure is 0.4MPa, and the spraying amount of the oligofructose aqueous solution is 1:1 with the mass ratio of the sodium hyaluronate raw material. After completion, dry at 55°C, pass through a 30-40 mesh sieve, and the final particle size is 30-40 mesh.

[0077] Example 2

[0078] The only difference between Example 2 and Example 1 is that in step 2, a mist of 5% erythritol aqueous solution is sprayed into the first hyaluronate particles.

[0079] Example 3

[0080] The only difference between Example 3 and Example 1 is that in step 2, a mist of 5% resistant dextrin aqueous solution is sprayed into the first hyaluronate particles.

[0081] Example 4

[0082] The only difference between Example 4 and Example 1 is that in step 2, a mist of 5% crystalline fructose aqueous solution is sprayed into the first hyaluronate particles.

[0083] Example 5

[0084] The only difference between Example 5 and Example 1 is that in step 2, a mist of 0.5% oligofructose aqueous solution is sprayed into the first hyaluronate particles.

[0085] Example 6

[0086] The only difference between Example 6 and Example 1 is that in step 2, a mist of 2% oligofructose aqueous solution is sprayed into the first hyaluronate particles.

[0087] Example 7

[0088] The only difference between Example 7 and Example 1 is that in step 2, a mist of 15% oligofructose aqueous solution is sprayed into the first hyaluronate particles.

[0089] Example 8

[0090] The only difference between Example 8 and Example 1 is that in step 2, a mist of 50% oligofructose aqueous solution is sprayed into the first hyaluronate particles.

[0091] Example 9

[0092] 1. Prepare a certain mass of sodium hyaluronate raw material (purchased from Huaxi Biotechnology Co., Ltd., batch number 1803234, molecular weight 1.37 million Da), use appropriate air volume under the fluidization state of the material, and the air flow temperature is 50°C. Spray a mist of 0.2% sodium hyaluronate (molecular weight 90,000 Da) aqueous solution, the compressed air pressure is 0.6MPa, and the amount of aqueous solution sprayed is two-thirds of the mass of the sodium hyaluronate raw material. After completion, dry at 50°C, pass through a 40-60 mesh sieve, and obtain material 1, whose particle size is 40-60 mesh.

[0093] 2. Use appropriate air volume while ensuring the fluidization of the material, and the air temperature is 50°C. Spray a 5% oligofructose aqueous solution into the material 1 in step 1, the compressed air pressure is 0.4MPa, and the spraying amount is the same as the mass of the sodium hyaluronate raw material. After completion, dry it at 55°C, pass through a 30-40 mesh sieve, and the final particle size is 30-40 mesh.

[0094] Example 10

[0095] The only difference between Example 10 and Example 1 is that the molecular weight of the sodium hyaluronate raw material is 400,000 Da.

[0096] Embodiment 11

[0097] The only difference between Example 11 and Example 1 is that in step 1, the mass ratio of the amount of water sprayed to the sodium hyaluronate raw material is 5:1.

[0098] Example 12

[0099] The only difference between Example 12 and Example 1 is that in step 1, the mass ratio of the amount of water sprayed to the sodium hyaluronate raw material is 10:1.

[0100] Embodiment 13

[0101] The only difference between Example 13 and Example 1 is that in step 2, the mass ratio of the sprayed fructo-oligosaccharide aqueous solution to the sodium hyaluronate raw material is 0.1:1.

[0102] Embodiment 14

[0103] The only difference between Example 14 and Example 1 is that in step 2, the mass ratio of the sprayed fructo-oligosaccharide aqueous solution to the sodium hyaluronate raw material is 10:1.

[0104] Embodiment 15

[0105] The only difference between Example 15 and Example 1 is that in step 2, the mass ratio of the sprayed fructo-oligosaccharide aqueous solution to the sodium hyaluronate raw material is 20:1.

[0106] Example 16

[0107] Prepare a certain mass of sodium hyaluronate raw material (purchased from Bloomage Biotechnology Co., Ltd., batch number 1803234, molecular weight 1.37 million Da), use appropriate air volume under the fluidization state of the material, and the air temperature is 50°C. Spray a mist of 5% oligofructose aqueous solution, the compressed air pressure is 0.4MPa, the spray amount of oligofructose aqueous solution and the mass ratio of sodium hyaluronate raw material is 1:1, and then dry at 55°C, pass through a 30-40 mesh sieve, and the final particle size is 30-40 mesh.

[0108] Embodiment 17

[0109] Prepare a certain amount of sodium hyaluronate raw material (purchased from Huaxi Biotechnology Co., Ltd., batch number 1803234, molecular weight of 1.37 million Da) and mix it evenly with oligofructose at a mass ratio of 20:1. Use an appropriate air volume while ensuring the fluidization of the material, and the air temperature is 50°C. Spray mist water, the compressed air pressure is 0.6MPa, and the mass ratio of the water spray amount to the sodium hyaluronate raw material and oligofructose mixture is 0.67:1. After completion, dry it at a temperature of 55°C, pass through a 30-40 mesh sieve, and the final particle size is 30-40 mesh.

[0110] Embodiment 18

[0111] The only difference between Example 18 and Example 17 is that the mass ratio of sodium hyaluronate raw material to oligofructose is 2:1.

[0112] Embodiment 19

[0113] The only difference between Example 19 and Example 17 is that the mass ratio of sodium hyaluronate raw material to oligofructose is 99:1.

[0114] Embodiment 20

[0115] The only difference between Example 20 and Example 17 is that the mass ratio of the amount of water sprayed to the sodium hyaluronate raw material and the oligofructose mixture is 20:1.

[0116] Comparative Example 1

[0117] Prepare a certain mass of sodium hyaluronate raw material (purchased from Bloomage Biotechnology Co., Ltd., batch number 1803234, molecular weight 1.37 million Da), use appropriate air volume under the fluidization state of the material, and the air flow temperature is 50°C. Spray mist water, the compressed air pressure is 0.6MPa, and the mass ratio of water spray to sodium hyaluronate raw material is 0.67:1. After completion, dry at 50°C, pass through a 40-60 mesh sieve, and obtain hyaluronate particles with a particle size of 40-60 mesh.

[0118] Comparative Example 2

[0119] Prepare a certain mass of sodium hyaluronate raw material (purchased from Bloomage Biotechnology Co., Ltd., batch number 1803234, molecular weight 1.37 million Da), use appropriate air volume under the fluidization state of the material, and the air flow temperature is 50°C. Spray a mist of 0.2% sodium hyaluronate (molecular weight 90,000 Da) aqueous solution, the compressed air pressure is 0.6MPa, and the spray amount of sodium hyaluronate aqueous solution and the mass ratio of sodium hyaluronate raw material are 0.67:1. After completion, dry at 50°C, pass through a 40-60 mesh sieve, and obtain hyaluronate particles with a particle size of 40-60 mesh.

[0120] Test example

[0121] The sodium hyaluronate particles obtained in the above examples and comparative examples, as well as the sodium hyaluronate raw material, were subjected to solubility tests.

[0122] Specifically, at room temperature (20°C-30°C), stirring was started at 1000 rpm (IKA stirrer), and the prepared sodium hyaluronate particles were slowly added into water, the mass concentration of the sodium hyaluronate particles in the water was 1%, and the solution was stirred until there was no agglomeration and the solution was uniform and transparent, indicating that the sodium hyaluronate was fully dissolved, and the dissolution time of each sodium hyaluronate particle was recorded.

[0123] The test results of various embodiments and comparative examples are shown in Table 1.

[0124] Table 1

[0125]

[0126]

Claims

1. A method for preparing a fast-dissolving hyaluronate, characterized in that: The instant hyaluronate is prepared by a boiling granulation method, and the preparation method comprises the following steps: After suspending the hyaluronate raw material in an air stream, spraying a binder solution to prepare hyaluronate particles, drying and sieving the hyaluronate particles to obtain instant hyaluronate; The binder is selected from one or more of monosaccharides, disaccharides, oligosaccharides, sugar alcohols, and soluble dietary fibers; The binder solution is an aqueous solution of a binder, wherein the concentration of the binder is 0.1wt%-60wt%; The mass ratio of the added amount of the adhesive solution to the hyaluronate raw material is (0.1-20):

1.

2. The preparation method according to claim 1, characterized in that: After the hyaluronate raw material is suspended in air flow and before the adhesive solution is sprayed, the following steps are also included: spraying water or an aqueous solution to prepare first hyaluronate particles, The first hyaluronate particles are dried.

3. The preparation method according to claim 2, characterized in that: The mass ratio of the added amount of water or aqueous solution to the hyaluronate raw material is (0.1-10):

1.

4. A method for preparing a fast-dissolving hyaluronate, characterized in that: The instant hyaluronate is prepared by a boiling granulation method, and the preparation method comprises the following steps: The hyaluronate raw material is mixed with a binder, suspended in an air stream, and then sprayed with water or an aqueous solution to prepare hyaluronate particles. Drying and sieving the hyaluronate particles to obtain instant hyaluronate; The binder is selected from one or more of monosaccharides, disaccharides, oligosaccharides, sugar alcohols, and soluble dietary fibers; The mass ratio of the hyaluronate raw material to the adhesive is (2-99): 1; The mass ratio of water or aqueous solution to the mixture of the hyaluronate raw material and the adhesive is (0.5-20):

1.

5. A fast-dissolving hyaluronate, prepared by the preparation method according to any one of claims 1 to 4.

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