Composite wall material sunscreen particles coated with sunscreen agent and preparation method and application thereof

Abstract

The present invention relates to a composite wall material sunscreen particle coated with a sunscreen agent and a preparation method and application thereof. The composite wall material sunscreen particle coated with the sunscreen agent is an O / W type multi-structure particle, which is obtained by self-assembly and cross-linking or curing of porous particles adsorbing the sunscreen agent and a protein as a blocking agent, and the self-assembly protein and emulsifier are attached to the outside of the particle; the composite wall material sunscreen particle coated with the sunscreen agent is an independent spherical particle, and its particle size distribution is 1-12 μm, the coverage rate is 18-32.71%, and the encapsulation rate is 47.8-73.7%. Compared with the prior art, the composite wall material sunscreen particle coated with the sunscreen agent of the present invention has a stable structure, is not easy to leak and be absorbed by the skin, can be well dispersed in an aqueous phase system, has good compatibility with a formula, can effectively reduce the amount of oil phase used for dissolving the sunscreen agent in the sunscreen product and avoid precipitation, and the sunscreen effect is significantly improved.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics processing, and in particular to composite wall material sunscreen particles coated with sunscreen agents, and a preparation method and application thereof. Background Art

[0002] Recently, consumers are paying more and more attention to the sunscreen performance of sunscreen products and the safety and comfort of the raw materials used in the products when purchasing products. The use of sunscreens may penetrate the stratum corneum of the skin and diffuse to the bottom layer, causing excessive absorption and sensitization of the skin. People use microencapsulation technology to provide a new idea for solving such problems. At the same time, in order to provide better light stability and safety, many materials are used to encapsulate sunscreens, and polymer nanoparticles are widely used. As human beings gradually increase their requirements for sustainable development and environmental protection, the European Union has tightened its policy on the use of non-biodegradable materials such as plastic microspheres in cosmetics. Many wall materials used for coating are non-degradable, and using natural wall materials instead of existing synthetic wall materials has become a better choice.

[0003] Existing sunscreens are highly irritating and the coated particles are poorly degradable. Therefore, there is an urgent need for composite wall material sunscreen particles coated with sunscreens, which can use natural wall materials instead of existing synthetic wall materials and can avoid the problems of conventional sunscreens such as unstable structure, easy leakage and absorption by the skin. In addition, it can reduce the amount of oil phase used to dissolve the sunscreen in sunscreen products and avoid precipitation, so as to improve the sunscreen effect. Summary of the invention

[0004] The purpose of the present invention is to overcome the defects of the above-mentioned prior art and to provide a composite wall material sunscreen particles coated with a sunscreen agent and a preparation method and application thereof. By adopting water-soluble proteins and starches, no organic solvents, acids and alkalis are used, which is safer and more environmentally friendly. The porous external film closed structure of porous starch forms a wrapping system with obvious optimization and improvement effects. The sunscreen agent made of composite wall material sunscreen particles prepared from porous starch and water-soluble proteins has a higher SPF value and more significant effect. In addition, it can solve the problems of greater irritation of existing sunscreen agents and poor degradability of coated particles.

[0005] The purpose of the present invention can be achieved by the following technical solutions:

[0006] The first object of the present invention is to provide a composite wall material sunscreen particles coated with a sunscreen, wherein the composite wall material sunscreen particles coated with a sunscreen are O / W type multi-structure particles; the composite wall material sunscreen particles coated with a sunscreen are obtained by self-assembly and cross-linking porous particles that adsorb the sunscreen and proteins that serve as blocking agents, and the porous particles in the composite wall material sunscreen particles coated with the sunscreen have self-assembled proteins and emulsifiers attached to the outside.

[0007] Furthermore, the composite wall material sunscreen particles coated with the sunscreen agent are independent spherical particles with a particle size distribution of 1-12 μm, a coating rate of 18-32.71%, and an encapsulation rate of 47.8-73.7%.

[0008] Furthermore, the composite wall material sunscreen particles coated with sunscreen agent include the following components and their weight contents (total amount 100 parts): 0.5-2 parts of protein, 0.5-2 parts of porous starch obtained after modification, 1-4 parts of fat-soluble sunscreen agent, 0.01-3 parts of emulsifier, 0-5 parts of crosslinking agent and the balance of deionized water.

[0009] Furthermore, the protein is a water-soluble protein.

[0010] Furthermore, the protein is one or a combination of soy protein, wheat protein, whey protein and gluten.

[0011] Furthermore, the fat-soluble sunscreen is one or a combination of octyl methoxycinnamate, diethylaminohydroxybenzoyl hexyl benzoate, benzophenone-3, homosalate and avobenzone.

[0012] Furthermore, the emulsifier is any one of anionic emulsifier and nonionic emulsifier or a mixture of both.

[0013] Furthermore, the emulsifier is at least one of sucrose ester 11, sodium lauryl sulfate, Tween 80, Span 80, Brij721, Brij72, glyceryl stearate and sodium cetearyl sulfate.

[0014] Furthermore, the cross-linking agent is at least one of transglutaminase, peroxidase and polyphenol oxidase.

[0015] Furthermore, the porous starch obtained after modification is one of porous corn starch obtained after modification, porous potato starch obtained after modification, and porous rice starch obtained after modification.

[0016] Further, the method for modifying porous starch is as follows:

[0017] 20g starch was dispersed in 40mL buffer solution (pH=4.0), stirred at 55℃ for 10min, and 0.4g α-amylase and saccharifying enzyme mixture was added. After stirring at 55℃ for 20h, 5mL NaOH (1mol / L) solution was added to terminate the reaction, and the reaction solution was filtered for solid-liquid separation. The obtained solid was washed with deionized water and filtered, and the washing was repeated three times. The washed solid was dried in an oven at 50℃, ground and sieved (100 mesh), and finally porous starch was obtained, which was stored in a dryer for use.

[0018] The second object of the present invention is to provide a method for preparing composite wall material sunscreen particles coated with sunscreen agent, comprising the following steps:

[0019] S1. Dissolve the solid fat-soluble UVA sunscreen in the oily fat-soluble UVB sunscreen in a water bath at 40°C-60°C, and stir thoroughly to dissolve to obtain a fat-soluble sunscreen;

[0020] S2, adding the modified porous starch to the fat-soluble sunscreen obtained in step S1, stirring, and fully dispersing to obtain an oil phase;

[0021] S3, adding the protein and emulsifier into deionized water in sequence, stirring, and fully dissolving to obtain an aqueous phase;

[0022] S4, adding the water phase obtained in step S3 to the oil phase obtained in S2 and homogenizing to obtain an emulsion, and then adding a cross-linking agent and drying and curing after cross-linking or directly drying and curing to obtain the composite wall material particles coated with the fat-soluble sunscreen agent.

[0023] Furthermore, in step S1, the temperature of the stirring and dissolving is 40°C-60°C.

[0024] Furthermore, in step S1, step S2 and step S3, the stirring speed is 400-600 r / min.

[0025] Furthermore, in step S4, the specific process of homogenization is: shearing with a homogenizer at a speed of 13000-25000 rpm for 10-15 minutes.

[0026] Furthermore, in step S4, the drying is carried out by air drying at room temperature, freeze drying or spray drying.

[0027] The third object of the present invention is to provide an application of composite wall material sunscreen particles coated with a sunscreen agent, and to use the composite wall material sunscreen particles coated with a sunscreen agent in the field of sunscreen cosmetics.

[0028] Furthermore, the sunscreen cosmetics include sunscreen and skin care cosmetics such as creams and lotions, color makeup products, etc.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] 1) The wall material used in the present invention is a natural component, safe, green, biodegradable, and not restricted by environmental protection policies; compared with other sunscreen encapsulation systems, the sunscreen particle wall material coated with protein and porous starch as a natural composite wall material has a stable structure, is not easy to leak and be absorbed by the skin, can be well dispersed in the water phase system, reduces the amount of oil phase used for dissolving sunscreen in sunscreen products and avoids precipitation, significantly improves the sunscreen effect, and has a broad application prospect.

[0031] 2) The present invention uses water-soluble protein and starch instead of organic solvents, acids and alkalis, and is safer and more environmentally friendly.

[0032] 3) In the preparation process of the composite wall material sunscreen particles coated with sunscreen provided by the present invention, the porous external film closed structure of porous starch forms a packaging system that has obvious optimization and improvement effects compared with other sunscreen packaging systems. The sunscreen made of the composite wall material sunscreen particles prepared from porous starch and water-soluble protein has a higher SPF value and more significant effect.

[0033] 4) The composite wall material sunscreen particles coated with sunscreen provided by the present invention have less irritation and the coated particles have better degradability. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 This is a scanning electron microscope image of the composite wall material sunscreen particles coated with sunscreen prepared in Example 1 of the present invention, wherein (a) and (b) are porous starch and sunscreen particles, respectively.

[0035] Figure 2 This is a particle size distribution diagram of the composite wall material sunscreen particles coated with sunscreen prepared in Example 3 of the present invention.

[0036] Figure 3 The sunscreen test diagrams of the sunscreens prepared in Application Example 2 of the present invention and Comparative Application Example 2 are shown.

[0037] Figure 4 This is a leakage test diagram of the present invention.

[0038] Figure 5 It is a schematic diagram of the mechanism of the present invention. DETAILED DESCRIPTION

[0039] The present invention is described in detail below in conjunction with the accompanying drawings and specific embodiments. The following embodiments will help those skilled in the art to further understand the present invention, but are not intended to limit the present invention in any form. It should be noted that, for those of ordinary skill in the art, several variations and improvements may be made without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0040] During the course of conception, the applicant believed that: using protein and porous starch as natural composite wall materials is safe, green, biodegradable, and not restricted by environmental protection policies; the sunscreen particles of the protein and porous starch composite wall materials are not easily absorbed by the skin compared with unwrapped sunscreens; at the same time, the solubility of oil-soluble sunscreens in the aqueous phase can be improved, the amount of oil used to dissolve the sunscreen can be reduced to avoid the precipitation of the sunscreen, and the sunscreen effect can be significantly improved, which has a broad application prospect; compared with other sunscreens, the use of water-soluble or hydrophilic wall materials also avoids the use of organic solvents, and the preparation process is simple and feasible, and there is no obvious safety risk in the production process; at the same time, the porous external membrane closed structure of porous starch can obtain O / W type multi-structure particles with self-assembled proteins and emulsifiers attached to the outside of the porous particles, which have the advantages of stable structure and not easy to leak.

[0041] like Figure 5 As shown, the composite wall material sunscreen particles coated with sunscreen are O / W type multi-structure particles; the composite wall material sunscreen particles coated with sunscreen are obtained by self-assembly and cross-linking of porous particles that adsorb sunscreen and proteins that serve as blocking agents, and the porous particles in the composite wall material sunscreen particles coated with sunscreen are attached with self-assembled proteins and emulsifiers on the outside.

[0042] Any features such as preparation methods, materials, structures or composition ratios that are not clearly described in this technical solution shall be deemed as common technical features disclosed in the prior art.

[0043] The modification method of the porous corn starch obtained after modification used in the following examples is:

[0044] 20g corn starch was dispersed in 40mL buffer solution (pH=4.0), stirred at 55℃ for 10min, and 0.4g α-amylase and saccharifying enzyme mixture was added. After stirring at 55℃ for 20h, 5mL NaOH (1mol / L) solution was added to terminate the reaction, and the reaction solution was filtered for solid-liquid separation. The obtained solid was washed with deionized water and filtered, and the washing was repeated three times. The washed solid was dried in an oven at 50℃, ground and sieved (100 mesh), and finally porous corn starch was obtained, which was stored in a dryer for use.

[0045] Other raw materials used in the following examples are all commercially available.

[0046] Example 1

[0047] The present embodiment provides a composite wall material sunscreen particle coated with a sunscreen agent, comprising the following components and their weight contents: protein (whey protein): 2 parts, porous starch obtained after modification (porous corn starch obtained after modification): 2 parts; fat-soluble sunscreen agent (2 parts of diethylaminohydroxybenzoyl hexyl benzoate, 2 parts of octyl methoxycinnamate): 4 parts; emulsifier (sucrose ester 11): 0.7 parts; cross-linking agent (transglutaminase): 1 part; deionized water: 90.3 parts.

[0048] The specific steps of the preparation method of the composite wall material sunscreen particles coated with sunscreen agent are as follows:

[0049] S1. In a 55°C water bath, add diethylaminohydroxybenzoyl hexyl benzoate to octyl methoxycinnamate, and fully stir and dissolve at a speed of 400 r / min to obtain a fat-soluble sunscreen;

[0050] S2, adding the porous corn starch obtained after modification to the fat-soluble sunscreen solution obtained in step S1, stirring at a speed of 400 r / min, and obtaining an oil phase after being fully dispersed;

[0051] S3, adding whey protein and sucrose ester 11 into deionized water in sequence, stirring at a speed of 400 r / min to fully dissolve, to obtain an aqueous phase;

[0052] S4, slowly adding the aqueous phase in step S3 to the oil phase in step S2, shearing for 15 minutes under a homogenizer at a speed of 13000 rpm to obtain an emulsion, then adding transglutaminase for cross-linking, spray drying to obtain the composite wall material particles coated with the fat-soluble sunscreen agent, that is, particles coated with diethylaminohydroxybenzoyl hexyl benzoate (DHHB) and octyl methoxycinnamate (EHMC) sunscreen agents, and heating and drying at 130° C. for 10 minutes.

[0053] The composite wall material sunscreen particles coated with sunscreen prepared in this example had a particle size distribution of 1-12 μm, a coating rate of 23%, and an encapsulation rate of 55.8%.

[0054] Example 2

[0055] The present embodiment provides a composite wall material sunscreen particle coated with a sunscreen agent, comprising the following components and their weight contents: protein (whey protein): 2 parts, porous starch obtained after modification (porous corn starch obtained after modification): 2 parts; fat-soluble sunscreen agent (2.66 parts of diethylamino hydroxybenzoyl hexyl benzoate, 1.33 parts of octyl methoxycinnamate): 4 parts; emulsifier (sucrose ester 11): 0.7 parts; deionized water: 91.3 parts.

[0056] The specific steps of the preparation method of the composite wall material sunscreen particles coated with sunscreen agent are as follows:

[0057] S1. In a 55°C water bath, add diethylaminohydroxybenzoyl hexyl benzoate to octyl methoxycinnamate, and fully stir and dissolve at a speed of 400 r / min to obtain a fat-soluble sunscreen;

[0058] S2, adding the porous corn starch obtained after modification to the fat-soluble sunscreen solution obtained in step S1, stirring at a speed of 400 r / min, and obtaining an oil phase after being fully dispersed;

[0059] S3, adding whey protein and sucrose ester 11 into deionized water in sequence, stirring at a speed of 400 r / min to fully dissolve, to obtain an aqueous phase;

[0060] S4, slowly adding the aqueous phase in step S3 to the oil phase in step S2, shearing for 15 minutes under a homogenizer at a speed of 13000 rpm to obtain an emulsion, spray drying to obtain the composite wall material particles coated with the fat-soluble sunscreen agent, i.e., particles coated with diethylamino hydroxybenzoyl hexyl benzoate (DHHB) and octyl methoxycinnamate (EHMC) sunscreen agents, and heating and drying at 130° C. for 10 minutes.

[0061] The scanning electron microscope image of the composite wall material sunscreen particles coated with sunscreen prepared in this example is as follows: Figure 1 As shown, the particles are independent spherical particles with a particle size distribution of 1-12 μm, a coverage rate of 32.71%, and an encapsulation rate of 73.7%.

[0062] Example 3

[0063] The present embodiment provides a composite wall material sunscreen particle coated with a sunscreen agent, comprising the following components and their weight contents: protein (whey protein): 1.34 parts, porous starch obtained after modification (porous corn starch obtained after modification): 2.66 parts; fat-soluble sunscreen agent (2 parts of diethylaminohydroxybenzoyl hexyl benzoate, 2 parts of octyl methoxycinnamate): 4 parts; emulsifier (sucrose ester 11): 0.7 parts; cross-linking agent (transglutaminase): 1 part; deionized water: 90.3 parts.

[0064] The specific steps of the preparation method of the composite wall material sunscreen particles coated with sunscreen agent are as follows:

[0065] S1. In a 55°C water bath, add diethylaminohydroxybenzoyl hexyl benzoate to octyl methoxycinnamate, and fully stir and dissolve at a speed of 400 r / min to obtain a fat-soluble sunscreen;

[0066] S2, adding the porous corn starch obtained after modification to the fat-soluble sunscreen solution obtained in step S1, stirring at a speed of 400 r / min, and obtaining an oil phase after being fully dispersed;

[0067] S3, adding whey protein and sucrose ester 11 into deionized water in sequence, stirring at a speed of 400 r / min to fully dissolve, to obtain an aqueous phase;

[0068] S4, slowly adding the aqueous phase in step S3 to the oil phase in step S2, shearing for 15 minutes under a homogenizer at a speed of 13000 rpm to obtain an emulsion, and then adding transglutaminase for cross-linking,

[0069] After spray drying, the composite wall material particles coated with the fat-soluble sunscreen agent are obtained, and the particle size distribution diagram is as follows: Figure 2 As shown, microparticles coated with diethylaminohydroxybenzoyl hexyl benzoate (DHHB) and octyl methoxycinnamate (EHMC) sunscreen agents were heated and dried at 130° C. for 10 minutes.

[0070] The composite wall material sunscreen particles coated with sunscreen prepared in this example had a particle size distribution of 1-12 μm, a coating rate of 18%, and an encapsulation rate of 47.8%.

[0071] Example 4

[0072] The present embodiment provides a composite wall material sunscreen particle coated with a sunscreen agent, comprising the following components and their weight contents: protein (whey protein): 2 parts, porous starch obtained after modification (porous corn starch obtained after modification): 2 parts; fat-soluble sunscreen agent (octyl methoxycinnamate): 1.33 parts; emulsifier (sucrose ester 15): 0.7 parts; cross-linking agent (transglutaminase): 1 part; deionized water: 92.97 parts.

[0073] The specific steps of the preparation method of the composite wall material sunscreen particles coated with sunscreen agent are as follows:

[0074] S1. Add octyl methoxycinnamate to a 55°C water bath and stir thoroughly at a speed of 400 r / min to obtain a fat-soluble sunscreen;

[0075] S2, adding the porous corn starch obtained after modification to the fat-soluble sunscreen solution obtained in step S1, stirring at a speed of 400 r / min, and obtaining an oil phase after being fully dispersed;

[0076] S3, adding whey protein and sucrose ester 15 into deionized water in sequence, stirring at a speed of 400 r / min to fully dissolve, to obtain an aqueous phase;

[0077] S4, slowly adding the aqueous phase in step S3 to the oil phase in step S2, shearing for 15 minutes under a homogenizer at a speed of 13000 rpm to obtain an emulsion, then adding transglutaminase for cross-linking, spray drying to obtain the composite wall material particles coated with the fat-soluble sunscreen agent, i.e., particles coated with octyl methoxycinnamate (EHMC) sunscreen agent, and heating and drying at 130° C. for 10 minutes.

[0078] The composite wall material sunscreen particles coated with sunscreen prepared in this example had a particle size distribution of 1-12 μm, a coating rate of 10%, and an encapsulation rate of 67.6%.

[0079] Application Example 1

[0080] In this application example 1, the composite wall material particles coated with the fat-soluble sunscreen agent obtained in example 2 are used to prepare a sunscreen, which includes the following components and their weight contents:

[0081] Phase A:

[0082]

[0083]

[0084] Phase B:

[0085] Glycerin 5 parts;

[0086] 0.2 parts of xanthan gum;

[0087] 36 parts of deionized water;

[0088] Phase C:

[0089] 33.8 parts of composite wall material particles coated with a fat-soluble sunscreen agent;

[0090] 10 parts of deionized water.

[0091] The preparation method of the sunscreen comprises the following steps:

[0092] S1. Accurately weigh each component in phase A into beaker A, and stir and dissolve them in a water bath at 80°C;

[0093] S2. Accurately weigh a certain amount of deionized water into beaker B, and dissolve the remaining components in beaker B in the deionized water;

[0094] S3. Slowly mix phase A and phase B, and homogenize using a homogenizer at a speed of r = 13000 rpm for 5 minutes;

[0095] S4, uniformly dispersing the components of phase C in deionized water, adding them to the emulsion prepared in S3 at a temperature below 50° C., and obtaining a sunscreen after sufficient stirring. The sunscreen contains sunscreen particles coated with DHHB and EHMC sunscreen agents.

[0096] Application Example 2

[0097] In this application example 2, the composite wall material particles coated with the fat-soluble sunscreen agent obtained in example 4 are used to prepare a sunscreen, which includes the following components and their weight contents:

[0098] Phase A:

[0099]

[0100]

[0101] Phase B:

[0102] Glycerin 5 parts;

[0103] 0.2 parts of xanthan gum;

[0104] 36 parts of deionized water;

[0105] Phase C:

[0106] 33.8 parts of composite wall material particles coated with a fat-soluble sunscreen agent;

[0107] 10 parts of deionized water.

[0108] The preparation method of the sunscreen comprises the following steps:

[0109] S1. Accurately weigh each component in phase A into beaker A, and stir and dissolve them in a water bath at 80°C;

[0110] S2. Accurately weigh a certain amount of deionized water into beaker B, and dissolve the remaining components in beaker B in the deionized water;

[0111] S3. Slowly mix phase A and phase B, and homogenize using a homogenizer at a speed of r = 13000 rpm for 5 minutes;

[0112] S4, uniformly dispersing the components of phase C in deionized water, adding them to the emulsion prepared in S3 at a temperature below 50° C., and obtaining a sunscreen after sufficient stirring. The sunscreen contains EHMC sunscreen particles coated therein.

[0113] Comparative Application Example 1

[0114] This comparative application example 1 provides a sunscreen (cream) with free sunscreen added, including the following components and contents by weight:

[0115] Phase A:

[0116]

[0117] Phase B:

[0118] Glycerin 5 parts;

[0119] 0.2 parts of xanthan gum;

[0120] Deionized water was added until the mass of the cream was 100 parts.

[0121] The method for preparing the sunscreen cream containing free sunscreen agent comprises the following steps:

[0122] S1. Accurately weigh each component in phase A into beaker A, and stir and dissolve them in a water bath at 80°C;

[0123] S2. Accurately weigh a certain amount of deionized water into beaker B, and dissolve the remaining components in beaker B in the deionized water;

[0124] S3. Slowly mix phase A and phase B, and homogenize using a homogenizer at a speed of r = 13000 rpm for 5 minutes;

[0125] S4, uniformly dispersing the components of phase C in deionized water, adding them to the emulsion prepared in S3 at a temperature below 50° C., and obtaining a sunscreen after sufficient stirring. The sunscreen contains sunscreen particles coated with DHHB and EHMC sunscreen agents.

[0126] Comparative Application Example 2

[0127] This comparative application implementation example 2 provides a sunscreen (cream) with free sunscreen added, including the following components and their weight contents:

[0128] Phase A:

[0129]

[0130] Phase B:

[0131] Glycerin 5 parts;

[0132] 0.2 parts of xanthan gum;

[0133] Deionized water was added until the mass of the cream was 100 parts.

[0134] The method for preparing the sunscreen cream containing free sunscreen agent comprises the following steps:

[0135] S1. Accurately weigh each component in phase A into beaker A, and stir and dissolve them in a water bath at 80°C;

[0136] S2. Accurately weigh a certain amount of deionized water into beaker B, and dissolve the remaining components in beaker B in the deionized water;

[0137] S3. Slowly mix phase A and phase B, and homogenize using a homogenizer at a speed of r = 13000 rpm for 5 minutes;

[0138] S4, uniformly dispersing the components of phase C in deionized water, adding them to the emulsion prepared in S3 at a temperature below 50° C., and obtaining a sunscreen after sufficient stirring. The sunscreen contains a free EHMC sunscreen agent.

[0139] Sunscreen effect test:

[0140] The sunscreens of Application Example 1 and Comparative Application Example 1 were subjected to an in vitro sunscreen test using an SPF-290AS instrument. The SPF value of Application Example 1 (21.74±0.08) was compared with the SPF value of Application Example 1 (13.4±0.2), and the comparison between the two showed that the anti-ultraviolet UVB protection ability was significantly improved by 62.24%. The PFA value of Application Example 1 (23.03±0.34) was compared with the PFA value of Application Example 1 (11.22±0.05), and the comparison between the two showed that the anti-ultraviolet UVA protection ability was improved by 105.26%, and the sunscreens had a full-band protection effect.

[0141] Light stability test:

[0142] The prepared sunscreen containing the sample to be tested (Application Example 2) and the sunscreen containing the sunscreen agent (Comparative Application Example 2) were evenly applied on the surface of the substrate, placed away from light at room temperature for 20 minutes, and irradiated under a solar simulator. The substrate was taken out at regular intervals to measure the SPF value. Figure 3 It can be seen that the SPF value of comparative application example 2 continued to decrease in 8 hours, decreasing by about 36.95%. However, the SPF value of application example 2 was basically stable after 6 hours, and its SPF value only decreased by about 12.46%, which was 66.28% higher than that of comparative application example 2. This shows that the prepared sunscreen has better light stability.

[0143] In vitro skin penetration test:

[0144] Using anhydrous ethanol as the receiving solution, samples were taken at specific time intervals over 120 hours, and the UV absorption at 311 nm and 356 nm was measured to evaluate the in vitro transdermal absorption of sunscreen particles and sunscreen agents DHHB and EHMC. Using pure sunscreen as the control, the penetration rate of DHHB and EHMC was very fast, penetrating the microporous filter within 1 hour, and the penetration rate could reach more than 90% within 120 hours. For the sunscreen particles, a small amount of DHHB penetration could be detected within 1 hour, and there was almost no penetration after 48 hours of release. The cumulative penetration rate of DHHB (diethylaminohydroxybenzoyl hexyl benzoate) was only 7.23%. The cumulative penetration rate of EHMC within 72 hours was only 5.25%. The results of the in vitro permeation test showed that the cumulative release of DHHB and EHMC in the sunscreen particles was much lower than that of the free sunscreen, which also confirmed that the prepared sunscreen particles had good coating effect and stability, effectively avoiding skin penetration and sunscreen leakage, and the results were shown in Figure 2. Figure 4 shown.

[0145] The above description of the embodiments is to facilitate the understanding and use of the invention by those skilled in the art. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above embodiments, and improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the scope of protection of the present invention.

Claims

1. A composite wall material sunscreen particle coated with a sunscreen agent, characterized in that: The composite wall material sunscreen particles coated with the sunscreen agent are O / W type multi-structure particles; The composite wall material sunscreen particles coated with sunscreen are obtained by cross-linking or curing porous particles adsorbing sunscreen and proteins as blocking agents through self-assembly, and the porous particles in the composite wall material sunscreen particles coated with sunscreen are attached with self-assembled proteins and emulsifiers. The composite wall material sunscreen particles coated with the sunscreen agent are independent spherical particles with a particle size distribution of 1-12 μm, a coverage rate of 18-32.71%, and an encapsulation rate of 47.8-73.7%; The composite wall material sunscreen particles coated with sunscreen agent include the following components and contents by weight: 0.5-2 parts of protein, 0.5-2 parts of porous starch obtained after modification, 1-4 parts of fat-soluble sunscreen, 0.01-3 parts of emulsifier, 0-5 parts of cross-linking agent and deionized water; The prepared sunscreen particles have good coating effect and stability, and can effectively prevent skin penetration and sunscreen agent leakage.

2. The composite wall material sunscreen particles coated with sunscreen agent according to claim 1, characterized in that: The protein is one or a combination of soy protein, wheat protein, whey protein and gluten.

3. The composite wall material sunscreen particles coated with sunscreen agent according to claim 1, characterized in that: The fat-soluble sunscreen is one or a combination of octyl methoxycinnamate, diethylaminohydroxybenzoyl hexyl benzoate, benzophenone-3, homosalate and avobenzone.

4. The composite wall material sunscreen particles coated with sunscreen agent according to claim 1, characterized in that: The emulsifier is any one of anionic emulsifier and nonionic emulsifier or a mixture of two; The emulsifier is at least one of sucrose ester 11, sodium lauryl sulfate, Tween 80, Span 80, Brij721, Brij72, glyceryl stearate and sodium cetearyl sulfate.

5. The composite wall material sunscreen particles coated with sunscreen agent according to claim 1, characterized in that: The cross-linking agent is at least one of transglutaminase, peroxidase and polyphenol oxidase.

6. The composite wall material sunscreen particles coated with sunscreen agent according to claim 1, characterized in that: The porous starch obtained after modification is one of porous corn starch obtained after modification, porous potato starch obtained after modification, and porous rice starch obtained after modification.

7. A method for preparing composite wall material sunscreen particles coated with sunscreen agent according to any one of claims 1 to 6, characterized in that: The method comprises the following steps: S1, dissolving a solid fat-soluble UVA sunscreen in an oily fat-soluble UVB sunscreen, stirring thoroughly to dissolve, to obtain a fat-soluble sunscreen; S2, adding the modified porous starch to the fat-soluble sunscreen obtained in step S1, stirring, and fully dispersing to obtain an oil phase; S3, adding the protein and emulsifier into deionized water in sequence, stirring, and fully dissolving to obtain an aqueous phase; S4, adding the water phase obtained in step S3 to the oil phase obtained in S2 and homogenizing to obtain an emulsion, and then adding a cross-linking agent and drying and curing after cross-linking or directly drying and curing to obtain the composite wall material particles coated with the fat-soluble sunscreen agent.

8. The method for preparing composite wall material sunscreen particles coated with sunscreen agent according to claim 7, characterized in that: In step S1, the temperature of stirring and dissolving is 40°C - 60°C; In step S1, step S2 and step S3, the stirring speed is 400-600 r / min; In step S4, the specific process of the homogenization is: shearing with a homogenizer at a speed of 13000-25000 rpm for 10-15 minutes; In step S4, the drying is performed by air drying at room temperature, freeze drying, or spray drying followed by thermal curing.

9. An application of composite wall material sunscreen particles coated with sunscreen agent as claimed in any one of claims 1 to 6, characterized in that: The composite wall material sunscreen particles coated with sunscreen agent are used in the field of sunscreen cosmetics.

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