A Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type and its application

Abstract

The present invention relates to a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type, which is made of the following raw materials in parts by weight: 4-8 parts of Fritillaria thunbergii, 4-8 parts of Rhizoma Cibotii, 1-5 parts of Sterculia lychnophora, 2-6 parts of Scrophularia ningpoensis, 4-8 parts of Radix Ophiopogonis, 1-5 parts of Radix Adenophorae, 4-8 parts of Radix Asparagi, 1-5 parts of Lilium, 1-5 parts of Patchouli, 1-5 parts of Mentha, and 2-4 parts of Liquorice. The present invention also provides the use of the Chinese medicine composition. Its advantages are: in the prescription, Fritillaria thunbergii, Rhizoma Cibotii, and Sterculia lychnophora are all monarch medicines, clearing away heat and relieving sore throat, resolving phlegm and relieving cough; Scrophularia ningpoensis, Radix Ophiopogonis, Radix Adenophorae, and Radix Asparagi are ministerial medicines, nourishing yin and clearing lungs, nourishing yin and promoting body fluid; Patchouli and Mentha are adjuvants, aromatic and dehumidifying and relieving sore throat; Liquorice is a messenger medicine, which harmonizes various medicines. The various medicines of this prescription are used together to play the effects of nourishing yin and relieving sore throat, clearing lungs and resolving phlegm.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating chronic pharyngolaryngitis of yin deficiency and lung dryness type and application thereof. Background Art

[0002] Chronic pharyngitis is a common disease, which is a diffuse pharyngeal lesion caused by chronic infection, mainly inflammation of the pharyngeal mucosa. Because the throat is located at the intersection of the respiratory tract and the digestive tract, long-term nonspecific stimulation from the throat and esophagus will cause throat discomfort. Various chronic diseases in the body, such as anemia, constipation, chronic inflammation of the lower respiratory tract, cardiovascular disease, etc., can also be secondary to this disease. Conscious throat discomfort, dryness, itching, swelling, a lot of secretions and burning pain, easy to dry nausea, a foreign body sensation, can not cough up, can not swallow, the above symptoms are aggravated when talking a little more, eating irritating food, fatigue or weather changes. Breathing and swallowing are not smooth and blocked by foreign bodies.

[0003] Western medicine generally focuses on local medication, such as: mouthwash, repeatedly gargling with 2% boric acid solution, 3% saline and 1:5000 furazolidone solution, or applying 2% iodine glycerol, 5% strong protein silver solution to the pharyngeal wall, or using iodine lozenges, domiphene, mint, etc. in the mouth, etc., which have a certain function of relieving symptoms. Local symptomatic treatment can also use Chinese patent medicine, such as coral lozenges, watermelon frost, etc.

[0004] Traditional Chinese medicine focuses on treating the root cause of this disease. It uses drugs according to the syndrome differentiation method and has a good effect. It is divided into 1. Exogenous pathogen invasion syndrome: (1) Wind-heat syndrome has severe pharyngeal pain, aggravated pain when swallowing, bright red pharyngeal mucosa, etc., and can be treated with Shufeng Qingre Decoction; (2) Wind-cold syndrome has mild pharyngeal pain, pale pharyngeal mucosa, accompanied by slight fever, etc., and can be treated with Liuwei Decoction. 2. Lung and stomach heat syndrome: Symptoms include severe redness, swelling and pain in the throat, difficulty swallowing, red and swollen granules or pus spots at the bottom of the throat, etc., and can be treated with Qingyan Lige Decoction. 3. Yin deficiency and lung dryness syndrome: Symptoms include dry throat, burning pain and discomfort, more severe in the afternoon, or pharyngeal obstruction, etc., and can be treated with Yangyin Qingfei Decoction combined with Zhibai Dihuang Decoction. 4. Spleen deficiency syndrome: Symptoms include pharyngeal obstruction or sticky feeling, dry throat, mild pain, pale red or slightly swollen pharyngeal mucosa, etc., and can be treated with Buzhong Yiqi Decoction. 5. Spleen and Kidney Yang Deficiency Syndrome: Symptoms include foreign body sensation in the throat, mild dry and painful throat, obstruction, etc. Fuzi Lizhong Pills can be used with modifications. 6. Phlegm coagulation and blood stasis syndrome: Symptoms include foreign body sensation in the throat, sticky phlegm, burning sensation in the throat, or slight pain in the throat, dry throat and no desire to drink, etc. Beimu Gualou Powder can be used with modifications.

[0005] There are many Chinese medicine compositions for treating chronic pharyngitis, but they all have more or less disadvantages, such as too many medicinal flavors, difficult to obtain materials, expensive prices, unclear efficacy, poor therapeutic effect, etc. Therefore, there is an urgent need for a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type in view of the deficiencies in the prior art.

[0007] Another object of the present invention is to provide a use of a traditional Chinese medicine composition.

[0008] To achieve the above object, the technical solution adopted by the present invention is:

[0009] A traditional Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type is prepared from the following raw materials in proportion by weight: 4-8 parts of thunbergii bulbs, 4-8 parts of cyperus rotundus, 1-5 parts of sterculia lychnophora, 2-6 parts of scrophularia, 4-8 parts of ophiopogon, 1-5 parts of northern adenophora, 4-8 parts of asparagus, 1-5 parts of lily, 1-5 parts of patchouli, 1-5 parts of mint and 2-4 parts of liquorice.

[0010] Preferably, the traditional Chinese medicine composition is made of the following raw materials in the following weight proportions: 5-7 parts of Fritillaria thunbergii, 5-7 parts of Sterculia lychnophora, 2-4 parts of Sterculia lychnophora, 3-5 parts of Scrophularia ningpoensis, 5-7 parts of Ophiopogon japonicus, 2-4 parts of Glehnia littoralis, 5-7 parts of Asparagus cochinchinensis, 2-4 parts of Lilium, 2-4 parts of Patchouli, 2-4 parts of Menthus fragrans, and 2-3 parts of Licorice.

[0011] More preferably, the Chinese medicine composition is made of the following raw materials in the following weight ratio: 6 parts of Fritillaria thunbergii, 6 parts of Sterculia lychnophora, 3 parts of Sterculia lychnophora, 4 parts of Scrophularia ningpoensis, 6 parts of Ophiopogon japonicus, 3 parts of Glehnia littoralis, 6 parts of Asparagus cochinchinensis, 3 parts of Lilium, 3 parts of Patchouli, 3 parts of Menthus fragrans, and 2 parts of Licorice.

[0012] To achieve the above second purpose, the technical solution adopted by the present invention is:

[0013] Use of any of the above-mentioned Chinese medicine compositions in the preparation of tea, food, health care products or medicines for treating chronic pharyngitis of yin deficiency and lung dryness type.

[0014] Preferably, the clinical manifestations of chronic pharyngitis of Yin deficiency and lung dryness type are dry and sore throat, burning sensation, aggravated symptoms after talking too much; choking cough with little sputum, frequent quest for drinking, but not much drinking; dark red congestion in the pharynx, dry mucosa, or atrophy, or lymph follicle hyperplasia; red tongue, thin coating, and thready pulse.

[0015] The present invention has the advantages that:

[0016] 1. In the prescription, Fritillaria thunbergii, Fructus tianzhu, and Sterculia lychnophora are the main drugs, which can clear away heat, relieve sore throat, resolve phlegm and relieve cough; Scrophularia ningpoensis, Radix Ophiopogonis, Radix Adenophorae, and Radix Asparagi are the assistant drugs, which can nourish yin and clear lungs, and nourish yin and promote body fluid; Patchouli and Mentha are the adjuvant drugs, which can remove dampness and relieve sore throat with aromatic properties; Licorice is the guiding drug, which can harmonize the drugs. The drugs in this prescription are used together to achieve the effects of nourishing yin and relieving sore throat, clearing lungs and resolving phlegm.

[0017] 2. The raw materials of the Chinese medicine composition of the present invention are easy to obtain, the preparation process is simple, and it is suitable for popularization and use. DETAILED DESCRIPTION

[0018] Example 1 Preparation of a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type (I)

[0019] 6 parts of Fritillaria thunbergii, 6 parts of Sterculia lychnophora, 3 parts of Sterculia lychnophora, 4 parts of Scrophularia ningpoensis, 6 parts of Ophiopogon japonicus, 3 parts of Glehnia littoralis, 6 parts of Asparagus cochinchinensis, 3 parts of Lilium, 3 parts of Patchouli, 3 parts of Mentha, and 2 parts of Licorice are brewed and taken orally using a conventional method.

[0020] Example 2 Preparation of a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type (II)

[0021] 6 parts of Fritillaria thunbergii, 5 parts of Sterculia lychnophora, 4 parts of Sterculia lychnophora, 2 parts of Scrophularia ningpoensis, 8 parts of Ophiopogon japonicus, 3 parts of Glehnia littoralis, 5 parts of Asparagus cochinchinensis, 4 parts of Lilium, 1 part of Patchouli, 5 parts of Mentha, and 2 parts of Liquorice are taken orally by conventional method.

[0022] Example 3 Preparation of a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type (III)

[0023] 5 parts of Fritillaria thunbergii, 7 parts of Sterculia lychnophora, 1 part of Sterculia lychnophora, 6 parts of Scrophularia ningpoensis, 6 parts of Ophiopogon japonicus, 2 parts of Glehnia littoralis, 7 parts of Asparagus cochinchinensis, 1 part of Lilium, 5 parts of Patchouli, 3 parts of Mentha, and 2 parts of Licorice are brewed and taken orally using a conventional method.

[0024] Example 4 Preparation of a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type (IV)

[0025] 7 parts of Fritillaria thunbergii, 4 parts of Sterculia lychnophora, 5 parts of Sterculia lychnophora, 4 parts of Scrophularia ningpoensis, 5 parts of Ophiopogon japonicus, 4 parts of Glehnia littoralis, 4 parts of Asparagus cochinchinensis, 5 parts of Lilium, 3 parts of Patchouli, 2 parts of Mentha, and 3 parts of Licorice are brewed and taken orally using a conventional method.

[0026] Example 5 Preparation of a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type (V)

[0027] 4 parts of Fritillaria thunbergii, 8 parts of Sterculia lychnophora, 3 ... Scrophularia ningpoensis, 7 parts of Ophiopogon japonicus, 1 part of Glehnia littoralis, 8 parts of Asparagus cochinchinensis, 3 parts of Lilium, 2 parts of Patchouli, 4 parts of Mentha, and 2 parts of Licorice are brewed and taken orally using a conventional method.

[0028] Example 6 Preparation of a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type (VI)

[0029] 8 parts of Fritillaria thunbergii, 6 parts of Sterculia lychnophora, 2 parts of Sterculia lychnophora, 5 parts of Scrophularia ningpoensis, 4 parts of Ophiopogon japonicus, 5 parts of Glehnia littoralis, 6 parts of Asparagus cochinchinensis, 2 parts of Lilium, 4 parts of Patchouli, 1 part of Mentha, and 4 parts of Licorice are brewed and taken orally in a conventional manner.

[0030] Example 7 Preparation of a Chinese medicine composition for treating chronic pharyngitis of Yin deficiency and lung dryness type (VII)

[0031] 6 parts of Fritillaria thunbergii, 7 parts of Sterculia lychnophora, 1 part of Sterculia lychnophora, 6 parts of Scrophularia ningpoensis, 6 parts of Ophiopogon japonicus, 2 parts of Glehnia littoralis, 7 parts of Asparagus cochinchinensis, 1 part of Lilium, 5 parts of Patchouli, 3 parts of Mentha, and 2 parts of Licorice are taken orally by conventional method.

[0032] Example 8 Preparation of a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type (VIII)

[0033] 5 parts of Fritillaria thunbergii, 4 parts of Sterculia lychnophora, 5 parts of Scrophularia ningpoensis, 5 parts of Ophiopogon japonicus, 4 parts of Glehnia littoralis, 4 parts of Asparagus cochinchinensis, 5 parts of Lilium, 3 parts of Patchouli, 2 parts of Mentha, and 3 parts of Licorice are brewed and taken orally using a conventional method.

[0034] Example 9 Preparation of a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type (IX)

[0035] 7 parts of Fritillaria thunbergii, 8 parts of Sterculia lychnophora, 3 ... Scrophularia ningpoensis, 7 parts of Ophiopogon japonicus, 1 part of Glehnia littoralis, 8 parts of Asparagus cochinchinensis, 3 parts of Lilium, 2 parts of Patchouli, 4 parts of Mentha, and 2 parts of Licorice are brewed and taken orally using a conventional method.

[0036] Example 10 Preparation of a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type (X)

[0037] 4 parts of Fritillaria thunbergii, 6 parts of Sterculia lychnophora, 2 parts of Sterculia lychnophora, 5 parts of Scrophularia ningpoensis, 4 parts of Ophiopogon japonicus, 5 parts of Glehnia littoralis, 6 parts of Asparagus cochinchinensis, 2 parts of Lilium, 4 parts of Patchouli, 1 part of Mentha, and 4 parts of Licorice are brewed and taken orally in a conventional manner.

[0038] Example 11 Preparation of a Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type (XI)

[0039] 8 parts of Fritillaria thunbergii, 5 parts of Sterculia lychnophora, 4 parts of Sterculia lychnophora, 2 parts of Scrophularia ningpoensis, 8 parts of Ophiopogon japonicus, 3 parts of Glehnia littoralis, 5 parts of Asparagus cochinchinensis, 4 parts of Lilium, 1 part of Patchouli, 5 parts of Mentha, and 2 parts of Licorice are taken orally by conventional method.

[0040] It should be noted that the conventional method described in Examples 1-11 is a conventional method for preparing Chinese herbal decoctions, that is, the raw materials are ground into fine particles, wrapped with non-woven fabrics, divided into small bags, and then brewed into tea with hot water.

[0041] Example 12 Clinical Trial

[0042] 1. Clinical data

[0043] 1.1 Case source

[0044] The 80 patients with chronic pharyngitis were all from the routine outpatient clinics of the Department of Prevention and Treatment of Diseases and the Department of Otorhinolaryngology of our hospital and voluntarily joined this trial.

[0045] 1.2 Diagnostic criteria

[0046] (1) Western medicine diagnostic standards: Western medicine diagnostic standards refer to the "Clinical Diagnosis and Treatment Guidelines - Otorhinolaryngology and Head and Neck Surgery" compiled by the Chinese Medical Association in 2009.

[0047] symptom:

[0048] ① The systemic symptoms of various types of chronic pharyngitis are not obvious, and local symptoms are the main symptoms;

[0049] ② Discomfort in the throat, such as foreign body sensation, burning sensation, itching, dryness or irritation, slight pain, etc. Sensitive throat, easy to feel nauseous;

[0050] ③ Irritating cough, without sputum or with granular lotus root powder-like secretions;

[0051] ④ If the inflammation affects the Eustachian tube, there will be symptoms such as tinnitus and hearing impairment. If it affects the larynx downward, hoarseness may occur.

[0052] examine:

[0053] ① The pharynx is sensitive and nausea may occur when the mouth is opened for pharyngeal examination;

[0054] ② The pharyngeal mucosa is congested and dark red, mostly located on the posterior pharyngeal wall, especially on the edge of the soft palate, palatine arch, and tonsils;

[0055] ③ A small number of scattered lymph follicles can be seen on the posterior pharyngeal wall, and the dilated and congested small blood vessels are connected to form a network;

[0056] ④The uvula can become thicker and droop to touch the root of the tongue.

[0057] (2) TCM diagnostic criteria:

[0058] According to the diagnostic criteria of chronic throat paralysis of Yin deficiency and lung dryness type in the "Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes", the symptoms are dry, sore and burning in the throat, and the symptoms worsen after talking too much; choking cough with little sputum, frequent requests for water, but the amount of water is not much, and the symptoms are obvious in the afternoon and evening. The pharynx is congested and dark red, the mucosa is dry, or atrophic, or there is lymph follicle hyperplasia. The tongue is red, the coating is thin, and the pulse is thin and rapid.

[0059] 1.3 Inclusion criteria

[0060] ① Those who meet the Western medical diagnostic criteria for chronic pharyngitis;

[0061] ②Those who meet the TCM diagnostic criteria for chronic laryngeal paralysis and TCM syndrome differentiation of yin deficiency and lung dryness;

[0062] ③ Those aged between 25 and 70;

[0063] ④ No medication to relieve chronic pharyngitis has been used, or the medication has been used but has been discontinued for two weeks or more.

[0064] 1.4 Exclusion criteria

[0065] ① Chronic pharyngitis accompanied by obvious tonsil enlargement;

[0066] ② Chronic pharyngitis accompanied by chronic rhinitis and chronic sinusitis;

[0067] ③Chronic pharyngitis accompanied by chronic inflammation of the lower respiratory tract and gastroesophageal reflux disease;

[0068] ④ Those under 25 years old or over 70 years old;

[0069] ⑤ Those who are known to be allergic to the drug;

[0070] ⑥ Pregnant or lactating women;

[0071] ⑦ Patients with severe primary diseases of the liver, heart, kidney and hematopoietic system, and mental illness.

[0072] 1.5 Rejection and shedding criteria

[0073] ① Those who did not meet the inclusion criteria and were mistakenly included;

[0074] ②Those who met the inclusion criteria but did not take medication after inclusion;

[0075] ③ During the treatment process, the subjects' compliance is poor, which affects the evaluation of drug effectiveness and safety;

[0076] ④ Those who have special physiological changes, serious adverse events and complications and should continue the trial;

[0077] ⑤ Those who voluntarily withdraw from the trial;

[0078] ⑥ Cases in which the patient withdrew from the trial, was lost to follow-up, or died before the end of the treatment due to various other reasons.

[0079] The reasons for all dropouts or exclusions must be recorded truthfully, and those who experience adverse reactions during medication will be included in the adverse reaction statistics.

[0080] 1.6 Treatment

[0081] 80 patients with chronic pharyngitis were given Qingfei Liyan tea for oral administration. The drugs were as follows: 6g of Fritillaria thunbergii, 6g of Tianzhuzi, 3g of Sterculia lychnophora, 4g of Scrophularia ningpoensis, 6g of Ophiopogon japonicus, 3g of Adenophora scutellariae, 6g of Asparagus cochinchinensis, 3g of Lilium bulgur, 3g of Patchouli, 3g of Mentha spicata, and 2g of Licorice. The preparation room processed the tea uniformly according to the formula, and made it into fine particles, which were wrapped with non-woven fabrics and packaged in small bags. When the patient took the tea, he added it to a container of about 500mL, filled it with boiling water, covered it and simmered it for 30 minutes before drinking. After drinking, he could drink it repeatedly several times, twice a day, 1 pack each time, and the course of treatment lasted for 4 weeks.

[0082] 1.7 Observation indicators

[0083] The main symptoms of dry throat and itchy throat were divided into four levels: normal (0 points), mild (3 points), moderate (6 points), and severe (9 points). The secondary symptoms of cough, expectoration, sore throat, foreign body in throat, posterior pharyngeal wall lymph follicles, posterior pharyngeal wall mucosa, and thick lateral pharyngeal cord were also divided into four levels: normal (0 points), mild (1 point), moderate (2 points), and severe (3 points). The scores were observed separately, and the tongue and pulse were not scored. The symptoms were quantified by their scores to monitor their changes before and after treatment.

[0084] Main symptoms:

[0085] (1) Dry throat: ①0 points: no dry throat; ②3 points: occasional dry throat; ③6 points: frequent dry throat; ④9 points: unbearable dry throat.

[0086] (2) Throat itching: ①0 points: no itching; ②3 points: occasional itching; ③6 points: frequent itching; ④9 points: unbearable itching, causing irritating cough.

[0087] Secondary symptoms:

[0088] (1) Cough: ①0 points: no cough; ②1 points: occasional cough; ③2 points: frequent cough; ④3 points: constant coughing, inability to speak, and affecting sleep.

[0089] (2) Sputum cough: ①0 points, no expectoration; ②1 points, occasional expectoration; ③2 points, frequent expectoration, 10 to 30 times a day; ④3 points, expectoration more than 30 times a day.

[0090] (3) Foreign body sensation in the throat: ①0 points: no foreign body sensation in the throat; ②1 points: occasional foreign body sensation in the throat; ③2 points: frequent foreign body sensation in the throat; ④3 points: foreign body sensation in the throat almost always exists.

[0091] (4) Throat pain: ①0 points, no pain; ②1 points, occasional pain; ③2 points, frequent pain; ④3 points, obvious pain.

[0092] (5) Lymph follicles of the posterior pharyngeal wall: ①0 points: none; ②1 points: 1-3 lymph follicles of the posterior pharyngeal wall; ③2 points: 4-6 lymph follicles of the posterior pharyngeal wall; ④3 points: 6 or more lymph follicles of the posterior pharyngeal wall.

[0093] (6) Posterior pharyngeal mucosa: ①0 points: smooth and moist posterior pharyngeal mucosa; ②1 points: less moist posterior pharyngeal mucosa; ③2 points: relatively dry posterior pharyngeal mucosa, showing moderate chronic congestion; ④3 points: obviously dry posterior pharyngeal mucosa, showing severe chronic congestion.

[0094] (7) Thickness of lateral pharyngeal cords: ①0 points: none; ②1 points: slight thickening of lateral pharyngeal cords; ③2 points: obvious thickening of lateral pharyngeal cords; ④3 points: obvious thickening of lateral pharyngeal cords with dark red color.

[0095] 1.8 Criteria for determining efficacy

[0096] Therapeutic index (n) = (score before treatment - score after treatment) / score before treatment × 100%;

[0097] Markedly effective: The main symptoms were significantly alleviated and most of the signs disappeared before and after treatment, n≥70%;

[0098] Effective: The main symptoms are alleviated and some signs disappear before and after treatment, 30%≤n<70%;

[0099] Ineffective: No significant improvement in symptoms and signs, n<30%.

[0100] Effective rate = (number of cured cases + number of effective cases) / total number of cases × 100%.

[0101] 2. Results

[0102] 2.1 Comparison of efficacy before and after treatment

[0103] According to the results of clinical research, 80 cases of chronic pharyngitis were treated with Qingfei Liyan Tea, of which 32 cases were markedly effective, 42 cases were effective, and 6 cases were ineffective, with a total effective rate of 92.5%. The symptom and sign scores before and after treatment were significantly improved, with significant statistical significance, as shown in Table 1.

[0104] Table 1 Comparison of efficacy before and after treatment

[0105]

[0106] 2.2 Pharyngeal symptom and sign scores before and after treatment

[0107] The total score before and after treatment was compared, p < 0.01, indicating that Qingfei Liyan Tea has a significant effect on improving the subjective symptoms and signs of chronic pharyngitis in the throat.

[0108] Table 2 Pharyngeal symptom and sign scores before and after treatment

[0109]

[0110] 3. Summary

[0111] Qingfei Liyan Tea is not only effective in treating chronic pharyngitis, but also has a definite effect on relieving the subjective symptoms and TCM syndromes of chronic pharyngitis.

[0112] Example 13 Animal Experiment

[0113] 1. Experimental Materials

[0114] 1.1 Animals

[0115] A total of 60 clean-grade male guinea pigs, 5-7 weeks old, weighing (220±20) g, were purchased from the Experimental Animal Center of Shanghai Academy of Medical Sciences.

[0116] 1.2 Drugs and reagents

[0117] Preparation of the Chinese medicine composition of the present invention: 6g of Fritillaria thunbergii, 6g of Sterculia lychnophora, 3g of Sterculia lychnophora, 4g of Scrophularia ningpoensis, 6g of Ophiopogon japonicus, 3g of Glehnia littoralis, 6g of Asparagus cochinchinensis, 3g of Lilium bulgur, 3g of Patchouli, 3g of Mentha, and 2g of Licorice, and the mixture is taken orally by conventional method;

[0118] Preparation of the second Chinese medicine composition of the present invention: 5g of Fritillaria thunbergii, 7g of Sterculia lychnophora, 1g of Sterculia lychnophora, 6g of Scrophularia ningpoensis, 6g of Ophiopogon japonicus, 2g of Glehnia littoralis, 7g of Asparagus cochinchinensis, 1g of Lilium bulgur, 5g of Patchouli, 3g of Mentha, and 2g of Licorice, and the mixture is taken orally by conventional method;

[0119] Control group 1 preparation: Fritillaria thunbergii 5g, Fructus tianzhu 7g, Sterculia lychnophora 1g, Cortex Lycii 6g, Ophiopogon japonicus 6g, Glehnia littoralis 2g, Fructus Ligustri Lucidi 7g, Lilium 1g, Patchouli 5g, Folium Mori 3g, Radix Glycyrrhizae 2g, soaked and taken by conventional method;

[0120] Preparation of control group 2: 6g of Fritillaria thunbergii, 6g of Sterculia lychnophora, 3g of Sterculia lychnophora, 4g of Scrophularia ningpoensis, 6g of Polygonatum odoratum, 3g of Glehnia littoralis, 6g of Asparagus cochinchinensis, 3g of Lycium barbarum, 3g of Magnolia officinalis, 3g of Mentha, 2g of Licorice, and taken orally by conventional method;

[0121] Model group: normal saline;

[0122] Blank group: normal saline.

[0123] Main reagents: ammonia water, turpentine, citric acid (Shanghai Aladdin).

[0124] 1.3 Main instruments

[0125] Tonsillar injection needle (Shanghai Shuangge); ultrasonic atomizer; laryngeal sprayer (Yangzhou, China).

[0126] 2. Methods

[0127] 2.1 Model establishment

[0128] After guinea pigs were adapted to feeding for 7 days, except for the guinea pigs in the normal group, the other groups were sprayed with 0.5% ammonia water on the pharynx 6 times, 1 spray each time, for a total of 7 days. From the 4th day, turpentine was injected into the pharynx of guinea pigs with a tonsil injection needle, 0.5 mL each time, once a day, for 4 consecutive days. On the 8th day, the guinea pigs were placed in a closed spray box and smoked with smoke liquid once a day, each time for 20 minutes, for 5 consecutive days. On the 13th day, 16% citric acid was sprayed to induce cough, and the ultrasonic atomizer was sprayed at the maximum spray intensity for 1 minute, the temperature was maintained at (20±2)℃, and the humidity was 50%-60%. When the guinea pigs scratched their mouths, drank water frequently but not much, the oral secretions increased, and the pharynx was locally congested and slightly swollen, it indicated that the model was successfully established. After the model was established, the drug regimen was gavaged for 10 consecutive days. The guinea pigs in the above groups were anesthetized 1 hour after the last gavage, and 2 mL of blood was collected by abdominal aorta cannulation under sterile conditions.

[0129] 2.2 Experimental plan

[0130] 50 mice with established models were randomly divided into the present invention group 1, the present invention group 2, the control group 1, the control group 2, and the model group, with 10 mice in each group. By detecting the behavioral state and weight change of mice, there was no shedding in the present invention group 1; the weight of the present invention group 2 was not up to standard, and 1 case of shedding; the behavior of the control group 1 was abnormal, and 2 cases of shedding; the weight of the control group 2 was overweight, and 1 case of shedding; there was no shedding in the model group.

[0131] 2.3 Detection indicators

[0132] The total white blood cell count, lymphocyte count, and eosinophil count were determined using an automatic hematology analyzer.

[0133] 2.4 Statistical methods

[0134] The statistical software GraphPad Prism8.0.2 was used for statistics. The means among multiple groups were compared by one-way analysis of variance, and the means among groups were compared by t-test, and P < 0.05 was considered statistically significant.

[0135] 2.5 Results

[0136] Compared with the blank group, the number of white blood cells and lymphocytes in the model group increased, p<0.05; compared with the model group, the number of white blood cells and lymphocytes in the control group and the treatment group decreased, and the treatment group had the best effect; there was no significant change in eosinophils, see Table 3.

[0137] Table 3 Results of blood indexes of guinea pigs in each group

[0138]

[0139] Note: &Compared with the blank group, p<0.05; *Compared with the model group, p<0.05; #Compared with the control group, p<0.05.

[0140] The above is only a preferred embodiment of the present invention. It should be pointed out that ordinary technicians in this technical field can make several improvements and supplements without departing from the method of the present invention. These improvements and supplements should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating chronic pharyngitis of yin deficiency and lung dryness type, characterized in that: The medicine is prepared from the following raw materials in proportion by weight: 4-8 parts of Fritillaria thunbergii, 4-8 parts of Sterculia lychnophora, 1-5 parts of Sterculia lychnophora, 2-6 parts of Scrophularia ningpoensis, 4-8 parts of Ophiopogon japonicus, 1-5 parts of Glehnia littoralis, 4-8 parts of Asparagus cochinchinensis, 1-5 parts of Lilium bulb, 1-5 parts of Patchouli vulgaris, 1-5 parts of Mentha arvense and 2-4 parts of Licorice.

2. The Chinese medicine composition according to claim 1, characterized in that The medicine is prepared from the following raw materials in proportion by weight: 5-7 parts of thunbergii bulbs, 5-7 parts of cyperus rotundus, 2-4 parts of sterculia lychnophora, 3-5 parts of scrophularia, 5-7 parts of ophiopogon, 2-4 parts of adenophora australis, 5-7 parts of asparagus cochinchinensis, 2-4 parts of lily, 2-4 parts of patchouli, 2-4 parts of mint and 2-3 parts of liquorice.

3. The Chinese medicine composition according to claim 2, characterized in that: The medicine is prepared from the following raw materials in proportion by weight: 6 parts of Fritillaria thunbergii, 6 parts of Sterculia lychnophora, 3 parts of Sterculia lychnophora, 4 parts of Scrophularia ningpoensis, 6 parts of Ophiopogon japonicus, 3 parts of Glehnia littoralis, 6 parts of Asparagus cochinchinensis, 3 parts of Lilium bulbs, 3 parts of Patchouli vulgaris, 3 parts of Mentha arvense and 2 parts of Licorice.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a drug for treating chronic pharyngitis of yin deficiency and lung dryness type.

5. The use according to claim 4, characterized in that: The clinical manifestations of chronic pharyngitis of Yin deficiency and lung dryness type are dry and sore throat, burning sensation, and worsening symptoms after talking too much; choking cough with little sputum, frequent requests for drinking, but not much; dark red congestion in the pharynx, dry mucosa, or atrophy, or lymph follicle hyperplasia; red tongue, thin coating, and thready pulse.

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