Antibacterial repair composition and use thereof, antibacterial repair sanitary napkin and preparation method thereof

Abstract

The present application discloses an antibacterial repair composition and its use, an antibacterial repair sanitary napkin and its preparation method; the antibacterial repair composition comprises: collagen peptide: 0.8-3 parts; Centella asiatica extract: 3-6 parts; yeast / rice fermentation product filtrate: 0.5-2 parts; Gleditsia sinensis extract: 0.5-2 parts; olive leaf extract: 1.5-4 parts. The present application selects collagen peptide, Centella asiatica extract, yeast / rice fermentation product filtrate and olive leaf extract as the antibacterial repair composition, which not only has excellent antibacterial effect, but also can comprehensively resist inflammation caused by skin problems and help the skin to repair quickly.

Description

Technical Field

[0001] The present application relates to the technical field of sanitary products, and in particular to an antibacterial repair composition and its use, an antibacterial repair sanitary napkin and its preparation method. Background Art

[0002] Sanitary napkins are sanitary products used by women during menstruation. Their main materials are cotton, non-woven fabrics, pulp or polymers and polymer composite paper formed by the above materials. The function of sanitary napkins is to absorb the menstrual blood flowing out of the vagina during menstruation.

[0003] With the progress and development of society, sanitary napkins, as female hygiene products, are no longer just considered for their basic purpose, and other related performances are also increasingly attracting the attention of consumers. Due to the endocrine effect of women's menstrual period, the menstrual blood produced by women during menstruation is accompanied by odor, and it is easy for bacteria to breed on sanitary napkins, which are prone to infection of reproductive system, urinary system and other diseases.

[0004] In the prior art, in order to achieve the sterilization function of sanitary napkins, some manufacturers will add sterilizing agents, such as nano-scale silver particles, into sanitary napkins. Studies have shown that although silver ions have a certain sterilization effect, long-term excessive use may pose a potential threat to the human body. Among them, long-term exposure to high concentrations of silver ions can cause damage to the skin, respiratory system, digestive system, etc. Summary of the invention

[0005] The purpose of the present application is to provide an antibacterial repair composition and its use, an antibacterial repair sanitary napkin and its preparation method.

[0006] In order to solve the above problems, this application proposes the following technical solutions:

[0007] In a first aspect, the present application provides an antibacterial repair composition, which comprises, by weight:

[0008] Collagen peptide: 0.8-3 parts;

[0009] Centella asiatica extract: 3-6 parts;

[0010] Yeast / rice fermentation product filtrate: 0.5-2 parts;

[0011] Gleditsia sinensis extract: 0.5-2 parts;

[0012] Olive leaf extract: 1.5-4 parts.

[0013] As an embodiment, the antibacterial repair composition comprises, by weight:

[0014] Collagen peptides: 1.5-2.5 parts;

[0015] Centella asiatica extract: 4-6 parts;

[0016] Yeast / rice fermentation product filtrate: 1-2 parts;

[0017] Gleditsia sinensis extract: 1-2 parts;

[0018] Olive leaf extract: 1.5-3.5 parts.

[0019] As a preferred embodiment, the weight ratio of the yeast / rice fermentation product filtrate to the Gleditsia sinensis extract is 1:1.

[0020] As an embodiment, the antibacterial repair composition further comprises:

[0021] Propylene glycol: 15-20 parts; and / or

[0022] Water: 20-30 parts.

[0023] In a second aspect, the present application provides a use of the antibacterial repair composition as described in the first aspect in the preparation of sanitary products.

[0024] Among them, the above-mentioned sanitary products include but are not limited to wet wipes and sanitary napkins.

[0025] In a third aspect, the present application provides an antibacterial repair sanitary napkin, the sanitary napkin comprising:

[0026] A sanitary napkin body and wings attached to both sides of the sanitary napkin body;

[0027] The sanitary napkin body comprises a cotton soft layer, an antibacterial layer, a water-absorbing layer, a bottom layer, a release paper and a film in sequence;

[0028] Wherein, the antibacterial layer contains the antibacterial repair composition described in the first aspect.

[0029] As an embodiment, the water absorbing layer is made of mesh non-woven fabric.

[0030] As an embodiment, the antibacterial layer is made of spunlace non-woven fabric.

[0031] As an embodiment, the method for preparing the antibacterial layer comprises:

[0032] According to the proportion, the collagen peptide, Centella asiatica extract, yeast / rice fermentation product filtrate, Gleditsia sinensis extract, olive leaf extract, water and / or propylene glycol are stirred and heated to 40-50° C., and mixed evenly to obtain an antibacterial repair composition;

[0033] The spunlace nonwoven fabric is immersed in the antibacterial repair composition at 25-30° C. for 10-15 minutes and then dried.

[0034] In a fourth aspect, the present application provides a method for preparing the antibacterial repair sanitary napkin as described in the third aspect, the method for preparing the sanitary napkin comprising:

[0035] After cutting to size, the cotton soft layer, the antibacterial layer, the water-absorbing layer, the bottom layer, the release paper and the wrapping film are bonded together in order to form the main body of the sanitary napkin;

[0036] The wings are attached to both sides of the sanitary napkin body to obtain the sanitary napkin.

[0037] Compared with the prior art, this application has at least the following beneficial effects:

[0038] The present application uses collagen peptide, Centella asiatica extract, yeast / rice fermentation product filtrate and olive leaf extract as the antibacterial repair composition, which not only has excellent antibacterial effect, but also can comprehensively resist inflammation caused by skin problems and help the skin to repair quickly. The above antibacterial repair composition is applied to sanitary products, which has excellent antibacterial and repair effects.

[0039] Additional aspects and advantages of the present application will be partially given in the following description, which will become apparent from the following description, or will be understood through the practice of the present application. DETAILED DESCRIPTION

[0040] In order to more fully understand the technical content of the present application, the present application will be further introduced and illustrated in conjunction with specific embodiments below; obviously, the described embodiments are only part of the embodiments of the present application, rather than all of the embodiments; based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making any creative work are within the scope of protection of the present application.

[0041] For those skilled in the art, the features, beneficial effects and advantages of the present application will become apparent by reading the contents disclosed in this specification.

[0042] The term "mass content" herein may be represented by the symbol "part(s)".

[0043] In the following schemes, the corresponding raw materials can be purchased from the market or prepared according to the common knowledge known in the art.

[0044] In the examples of the present application, collagen peptides were purchased from Guangdong Baiwei Biotechnology Co., Ltd., Centella asiatica extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., yeast / rice fermentation product filtrate was purchased from Guangzhou Zhaoyi Biotechnology Co., Ltd., saponin extract was purchased from Guangzhou Baoyi Biotechnology Co., Ltd., and olive leaf extract was purchased from Guangzhou Shengkais Chemical Co., Ltd.

[0045] The antibacterial repair composition of the present application is described in detail below.

[0046] Antibacterial repair composition

[0047] The antibacterial repair composition of the present application comprises: collagen peptide, Centella asiatica extract, yeast / rice fermentation product filtrate, sapodilla extract and olive leaf extract.

[0048] The Centella asiatica extract used in this application has antibacterial and anti-inflammatory effects. At the same time, the Centella asiatica extract tightens the connection between the epidermis and the dermis, making the connection between the epidermis and the dermis more compact, and can help the formation of collagen in the dermis, regenerate fibrin and reconnect, thereby achieving a repairing effect on the skin.

[0049] However, the skin utilization rate of Centella asiatica extract is relatively low, and its effect is difficult to exert, especially on damaged skin. In the prior art, some penetration enhancers are usually used to help skin utilization, such as menthol and azone, but the above-mentioned penetration enhancers are irritating and can easily cause irritation to the skin during use.

[0050] The collagen peptide used in this application has peptide molecules that can be quickly absorbed, thereby repairing the body's skin cells, repairing the skin barrier, restoring skin elasticity, and restoring skin radiance. It can also reduce inflammatory responses and reduce the level of inflammatory mediators in the body.

[0051] The yeast / rice fermentation product filtrate used in the present application can activate body cells and prevent skin roughness; it has a small molecular weight and super strong permeability, can quickly penetrate the skin, promote epidermal cell activation and renewal, and at the same time can promote collagen production and elastic fiber renewal, thereby increasing skin elasticity.

[0052] The soapberry extract used in the present application has a good antibacterial effect on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Enterobacter cloacae, Salmonella enterica and Candida albicans.

[0053] The olive leaf extract used in the present application not only has excellent antibacterial effect, but also can promote fibroblasts to produce collagen, thereby increasing skin elasticity.

[0054] The present application uses collagen peptide, Centella asiatica extract, yeast / rice fermentation product filtrate and olive leaf extract as the antibacterial repair composition, which not only has excellent antibacterial effect, but also can comprehensively resist the inflammation caused by skin problems and help the skin to repair quickly. The principle may be:

[0055] On the one hand, collagen peptides and yeast / rice fermentation product filtrate both have excellent permeability, can quickly repair the body's skin cells, rebuild the skin barrier, and promote the skin's absorption of Centella asiatica extract, thereby improving the skin utilization rate of Centella asiatica extract; on the other hand, the Centella asiatica extract with significantly improved skin utilization rate can not only participate in the bactericidal effect of Gleditsia sinensis extract and olive leaf extract, thereby improving the overall bactericidal performance of the antibacterial repair composition, but can also work together with olive leaf extract, collagen peptides and yeast / rice fermentation product filtrate to further resist inflammation caused by the skin and promote the production of collagen and the renewal of elastic fibers, thereby increasing skin elasticity and achieving the effect of repairing the skin.

[0056] The antibacterial repair composition provided in the present application has the dual effects of antibacterial and skin repair.

[0057] The antibacterial repair composition provided in the present application adopts collagen peptides, yeast / rice fermentation product filtrate and various plant extracts, and the use process is gentle and non-irritating.

[0058] In the present application, the contents of the above components are respectively calculated by weight: collagen peptide: 0.8-3 parts; Centella asiatica extract: 3-6 parts; yeast / rice fermentation product filtrate: 0.5-2 parts; saponin extract: 0.5-2 parts; olive leaf extract: 1.5-4 parts.

[0059] As a preferred technical solution of the present application, the contents of the above components are respectively: collagen peptide: 1.5-2.5 parts; Centella asiatica extract: 4-6 parts; yeast / rice fermentation product filtrate: 1-2 parts; saponin extract: 1-2 parts; olive leaf extract: 1.5-3.5 parts.

[0060] For example, in this application:

[0061] The content of collagen peptides includes but is not limited to: 0.8 parts, 0.9 parts, 1.0 parts, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2.0 parts, 2.1 parts, 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts, 2.8 parts, 2.9 parts, and 3.0 parts.

[0062] The content of Centella asiatica extract includes but is not limited to: 3 parts, 3.5 parts, 3.8 parts, 3.9 parts, 4 parts, 4.7 parts, 5 parts, 5.2 parts, 5.4 parts, 5.5 parts, 5.7 parts, 5.9 parts, and 6 parts.

[0063] The contents of the yeast / rice fermentation product filtrate include but are not limited to: 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1.0 parts, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, and 2.0 parts.

[0064] The content of saponin extract includes but is not limited to: 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1.0 parts, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, and 2.0 parts.

[0065] The content of olive leaf extract includes but is not limited to: 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2.0 parts, 2.1 parts, 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts, 2.8 parts, 2.9 parts, 3.0 parts, 3 parts, 3.5 parts, 3.8 parts, 3.9 parts, and 4 parts.

[0066] As a more preferred technical solution of the present application, in the antibacterial repair composition, the weight ratio of the yeast / rice fermentation product filtrate to the saponin extract is 1: 1. The present application confirms through relevant experiments that within this range, the antibacterial repair composition of the present application has better antibacterial and repair effects.

[0067] Other components

[0068] In addition to the above components, the antibacterial repair composition of the present application may reasonably use other additives, such as solvents, within the scope that does not significantly damage the effect of the present application.

[0069] Wherein, the solvent can be selected from propylene glycol and / or water.

[0070] In the present application, the amount of propylene glycol used is usually 15-20 parts, and the amount of water used is usually 20-30 parts.

[0071] The water is preferably purified water.

[0072] For example, the amount of water used can be: 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts.

[0073] The amount of propylene glycol used can be: 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts.

[0074] The antibacterial repair composition of the present application is preferably in liquid form, that is, an antibacterial repair liquid.

[0075] Preparation method

[0076] The antibacterial repair composition of the present application can be prepared by methods known in the art.

[0077] For example, the preparation method of the above antibacterial repair composition comprises:

[0078] According to the proportion, collagen peptide, Centella asiatica extract, yeast / rice fermentation product filtrate, Gleditsia sinensis extract, olive leaf extract, water and / or propylene glycol are stirred and heated to 40-50° C., and the antibacterial repair composition is obtained after mixing evenly.

[0079] The antibacterial repair composition provided in the present application can be used to prepare sanitary products, for example, wet wipes or sanitary napkins.

[0080] The wet wipes and antibacterial repair sanitary napkins of the present application will be further introduced below.

[0081] Wet wipes

[0082] The wet wipes of the present application include spunlace nonwoven fabrics and the above antibacterial repair composition (antibacterial repair liquid). Specifically, the spunlace nonwoven fabrics are soaked in the antibacterial repair composition at 25-30° C. for 10-15 minutes to obtain the wet wipes.

[0083] Typically, the content of the antibacterial repair liquid in the wet wipes is 75-85%, preferably 80-83%.

[0084] Therefore, the wet wipes of the present application not only have excellent antibacterial effects, but can also comprehensively resist inflammation caused by skin problems and help the skin to repair quickly.

[0085] sanitary napkin

[0086] The sanitary napkin of the present application comprises a sanitary napkin body and wings adhered to both sides of the sanitary napkin body; wherein the sanitary napkin body comprises a cotton soft layer, an antibacterial layer, a water-absorbing layer, a bottom layer, a release paper and a film in sequence.

[0087] The antibacterial layer contains the antibacterial repair composition (antibacterial repair liquid) mentioned above.

[0088] The preparation method of the above-mentioned sanitary napkin comprises:

[0089] After cutting to size, the cotton soft layer, antibacterial layer, water-absorbing layer, bottom layer, release paper and wrapping film are bonded together in order to form a sanitary napkin body, and then the wings are attached to both sides of the sanitary napkin body to obtain a sanitary napkin.

[0090] Among them, the water-absorbing layer is preferably made of mesh non-woven fabric, and the antibacterial layer is preferably made of spunlace non-woven fabric.

[0091] In the embodiment of the present application, the preparation method of the antibacterial layer is:

[0092] According to the proportion, the collagen peptide, Centella asiatica extract, yeast / rice fermentation product filtrate, Gleditsia sinensis extract, olive leaf extract, water and / or propylene glycol are stirred and heated to 40-50° C., and mixed evenly to obtain an antibacterial repair composition;

[0093] The spunlace nonwoven fabric is immersed in the antibacterial repair composition at 25-30° C. for 10-15 minutes and then dried.

[0094] Therefore, the sanitary napkin of the present application not only has the care function of ordinary sanitary napkins, but also has excellent antibacterial effect, and can also comprehensively resist inflammation caused by skin problems and help the skin to repair quickly.

[0095] The present application is further described below in conjunction with the examples. It should be understood that these examples are only used to illustrate the present application and are not used to limit the scope of the present application.

[0096] In the following examples, the materials, reagents and instruments used can be purchased from commercial sources unless otherwise specified.

[0097] Example 1-Example 6

[0098] In this application, an antibacterial repair solution having the following embodiments was prepared, and the specific composition is shown in Table 1.

[0099] Table 1: Components and dosages of Examples 1-6 (parts)

[0100] Components Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Collagen Peptides 0.8 1.5 2.5 3 2 3 Centella Asiatica Extract 6 5 4 3 4 4.5 Yeast / Rice Ferment Filtrate 1 2 1.5 0.5 1 1.5 Gleditsia sinensis extract 1 0.5 1.5 2 0.5 1 Olive Leaf Extract 2.7 2.5 2 3 4 1.5 Propylene glycol 18 18 18 18 18 18 water 22 22 22 22 22 22

[0101] Comparative Example 1-Comparative Example 5

[0102] The following comparative example of antibacterial repair liquid was also prepared in the present application, and the specific composition is shown in Table 2.

[0103] Table 2: Components and dosages of Comparative Examples 1-5 (parts)

[0104] Components Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Collagen Peptides - 3 3.5 2.5 2.5 Centella Asiatica Extract 5.5 5 - 4.5 5 Yeast / Rice Ferment Filtrate 2.5 - 2.5 1.5 1.5 Gleditsia sinensis extract 1.5 1.5 2.5 - 2.5 Olive Leaf Extract 2 2 3 3 - Propylene glycol 18 18 18 18 18 water 22 22 22 22 22

[0105] The preparation method of the antibacterial repair liquid of Examples 1-6 and Comparative Examples 1-5 comprises the following steps:

[0106] According to the proportion, the collagen peptide, Centella asiatica extract, yeast / rice fermentation product filtrate, saponin extract, olive leaf extract, water and / or propylene glycol are stirred and heated to 45° C., and the antibacterial repair solution is obtained after mixing evenly.

[0107] Effect verification

[0108] The effects of the antibacterial repair liquid prepared in the above Examples 1-6 and Comparative Examples 1-5 were verified, specifically including:

[0109] Antibacterial performance test:

[0110] The spunlace nonwoven fabric was immersed in the corresponding antibacterial repair liquid at 25° C. for 15 minutes to obtain the antibacterial repair wet wipes.

[0111] The antibacterial properties of the wet wipes were determined with reference to FZ / T73023-2006 "Antibacterial Knitwear", and the test strains were: Escherichia coli, Staphylococcus aureus, and Candida albicans. The antibacterial properties were expressed as the inhibition rate. The test results are shown in Table 3 below.

[0112] Table 3: Antibacterial rate (%) of Examples 1-6 and Comparative Examples 1-5

[0113] Antibacterial rate Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Escherichia coli 99.5 98.5 99.5 98.2 98.3 98.6 86.6 88.2 82.5 81.5 80.9 Staphylococcus aureus 98.6 98.2 99.8 97.4 97.3 97.8 86.7 88.5 82.7 81.3 80.7 Candida albicans 98.2 96.8 98.7 96.5 96.6 96.9 85.8 87.6 81.8 80.4 80.0

[0114] According to the test results in Table 3, Examples 1-5 of the present application selected collagen peptides, Centella asiatica extract, yeast / rice fermentation product filtrate and olive leaf extract as antibacterial repair compositions, which have excellent antibacterial effects.

[0115] Among them, in Comparative Example 1-2, due to the lack of collagen peptides or yeast / rice fermentation product filtrate, the skin utilization rate of Centella asiatica extract was significantly reduced, which in turn caused the antibacterial effect of Comparative Example 1-2 to be significantly weakened.

[0116] In Comparative Examples 3-5, due to the lack of Centella asiatica extract, Gleditsia sinensis extract or Olive Leaf Extract, the antibacterial effect of Comparative Examples 3-5 is also significantly weakened, indicating that Centella asiatica extract, Gleditsia sinensis extract and Olive Leaf Extract have a synergistic effect in antibacterial effect.

[0117] Skin penetration test of Centella asiatica extract

[0118] The skin permeation test of the Centella asiatica extract refers to the existing Franz diffusion cell method;

[0119] The specific experimental steps are:

[0120] The dorsal skin of healthy male Wistar rats was used as the permeability barrier in an in vitro Franz diffusion cell experiment;

[0121] Fix the intact skin between the receiving pool and the supply pool (with the inner layer of the skin facing the receiving pool) to ensure that there are no bubbles between the skin and the receiving solution;

[0122] Diffusion cell parameters: effective diffusion area is about 3.15cm 2, the volume of the receiving cell was about 8.8 mL, the magnetic stirring speed was 600 rpm, and the temperature of the receiving solution was 36.0 ± 0.1 °C;

[0123] The receiving pool was filled with the release medium 1% SDS-10% ethanol-normal saline, bubbles were removed, stirring was started, and the temperature was kept constant at (36.0±0.1)℃, and about 1g of the sample was evenly applied to the skin surface (n=8);

[0124] At 1, 2, 4, 6, 8, 10, and 12 hours, 0.5 mL of the receiving solution was drawn, and the same volume of release medium at the same temperature was added immediately after sampling. The concentration of the Centella asiatica extract in the receiving solution filtered through a 0.22 μm filter membrane was determined by HPLC. The cumulative drug permeation at different times was calculated.

[0125] The cumulative transdermal amount of Centella asiatica extract per unit area was calculated according to the following formula:

[0126] ;

[0127] In the above formula: Q: cumulative transdermal amount; S: effective diffusion area; V: volume of saline in the receiving pool; C i : drug concentration in the receiving solution from the first sampling to the last sampling; C n : drug concentration in the receiving solution during sampling; m0: theoretical sample weight; m: actual sample weight.

[0128] The test results are shown in Table 4.

[0129] Table 4: Cumulative skin penetration of Centella asiatica extract (12h)

[0130] Example 3 Comparative Example 1 Comparative Example 2 Cumulative permeation of Centella asiatica extract <![CDATA[1424μg / cm 2 ]]> <![CDATA[525μg / cm 2 ]]> <![CDATA[568μg / cm 2 ]]>

[0131] According to the test results in Table 4, in the absence of one of the collagen peptides or the yeast / rice fermentation product filtrate, the skin utilization rate of the Centella asiatica extract decreases significantly, indicating that in the scheme of the present application, the combined action of the collagen peptides and the yeast / rice fermentation product filtrate can quickly repair the body's skin cells, rebuild the skin barrier, and promote the skin's absorption of the Centella asiatica extract, thereby improving the skin utilization rate of the Centella asiatica extract and further exerting the antibacterial and repairing effect of the Centella asiatica extract.

[0132] Repair effect test

[0133] Test subjects: 110 healthy women aged 25-45, divided into 11 groups, 10 people in each group.

[0134] Test area: face (the left face is blank control, the right face uses comparative example sample or embodiment sample).

[0135] Usage: Apply once in the morning and evening (same dosage) for 28 days.

[0136] Testing instrument: CK skin tester (Germany)

[0137] Test parameters: moisture content of skin stratum corneum, transepidermal water loss

[0138] After 28 days, the CK skin tester (Germany) was used to measure the change rate of the moisture content of the stratum corneum and the change rate of the transepidermal water loss of the skin. The higher the change rate of the moisture content of the stratum corneum, the better the moisture content of the skin; the lower the change rate of the transepidermal water loss, the better the skin barrier. The test results are shown in Table 5.

[0139] Table 5:

[0140] Sample set Moisture content change rate (%) Transepidermal water loss change rate (%) Example 1 5.46 1.53 Example 2 5.55 1.45 Example 3 5.68 1.34 Example 4 5.52 1.43 Example 5 5.25 1.64 Example 6 5.26 1.66 Comparative Example 1 3.02 2.89 Comparative Example 2 3.15 2.75 Comparative Example 3 3.55 2.08 Comparative Example 4 4.46 1.87 Comparative Example 5 4.35 1.91

[0141] According to the test results in Table 5, Examples 1-6 of the present application can effectively help the skin to repair quickly by selecting collagen peptides, Centella asiatica extract, yeast / rice fermentation product filtrate and olive leaf extract as antibacterial repair compositions.

[0142] Among them, in Comparative Example 1-2, in the absence of collagen peptides or yeast / rice fermentation product filtrate, the skin utilization rate of Centella asiatica extract was significantly reduced. At the same time, since collagen peptides and yeast / rice fermentation product filtrate themselves can repair the body's skin cells and rebuild the skin barrier, the repair effect of Comparative Example 1-2 was significantly weakened.

[0143] In Comparative Example 3, due to the lack of Centella asiatica extract, its repair effect was significantly weakened, indicating that Centella asiatica extract and collagen peptides, yeast / rice fermentation product filtrate have a synergistic effect in repair.

[0144] When the comparative examples 4-5 lacked the saponin extract or the olive leaf extract, the repair effect of the comparative examples 4-5 was also weakened, indicating that the saponin extract and the olive leaf extract also had some influence on the repair effect in the scheme of the present application, but the overall influence was relatively small.

[0145] Safety Testing

[0146] 1. Number of testers: 36 in total, including 18 males and 18 females; youngest age: 25 years old, oldest age: 40 years old; the average age meets the inclusion criteria.

[0147] 2. Test method: Examples 1-6 were patch tested. A qualified patch tester was selected, and the test substance of about 0.020-0.025 mL was placed in the patch tester using the closed patch test method. The test substance was applied to the back of the subject with medical tape. The test substance was removed after 24 hours. The skin reaction was observed at 0.5, 24, and 48 hours after the patch was removed, and the results were recorded according to the skin reaction grading standard in the "Technical Specifications for Safety of Cosmetics" (2015 edition). The evaluation criteria are shown in Table 6 below, and the test results are shown in Table 7.

[0148] Table 6: Grading criteria for adverse skin reactions

[0149] Degree of reaction Rating scale Skin reactions — 0 Negative reaction ± 1 Suspected reaction: only slight erythema ＋ 2 Weak positive reaction (erythema reaction): erythema, infiltration, edema, and papules may be present ＋＋ 3 Strong positive reaction (herpes reaction): erythema, infiltration, edema, papules, herpes: the reaction may extend beyond the test area ＋＋＋ 4 Very strong positive reaction (confluent herpes reaction): obvious erythema, severe infiltration, edema, confluent herpes: reaction beyond the test area

[0150] Table 7: Safety test results

[0151] Rating scale Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 0.5(h) 0 0 0 0 0 0 24(h) 0 0 0 0 0 0 48(h) 0 0 0 0 0 0

[0152] The results in Table 7 show that in the human skin closed patch test of Examples 1-6, no positive reactions were observed among the 30 subjects. According to the Technical Specifications for Safety of Cosmetics (2015 edition), the test substances will not cause adverse skin reactions in this batch of subjects.

[0153] In summary, the present application selects collagen peptides, Centella asiatica extract, yeast / rice fermentation product filtrate and olive leaf extract as the antibacterial repair composition, which not only has excellent antibacterial effect, but also can comprehensively resist the inflammation caused by skin problems and help the skin to repair quickly.

[0154] The technical solutions provided in the embodiments of the present application are introduced in detail above. Specific examples are used herein to illustrate the principles and implementation methods of the embodiments of the present application. The description of the above embodiments is only applicable to help understand the principles of the embodiments of the present application. At the same time, for those skilled in the art, according to the embodiments of the present application, there will be changes in the specific implementation methods and application scopes. In summary, the contents of this specification should not be understood as limiting the present application.

Claims

1. An application of an antibacterial repair composition for increasing skin absorption of Centella asiatica extract, characterized in that: The antibacterial repair composition is composed of the following components by weight: Collagen peptide: 0.8-3 parts; Centella asiatica extract: 3-6 parts; Yeast rice fermentation product filtrate: 0.5-2 parts; Gleditsia sinensis extract: 0.5-2 parts; Olive leaf extract: 1.5-4 parts; Propylene glycol: 15-20 parts; Water: 20-30 parts; The mass ratio of the yeast rice fermentation product filtrate to the sapodilla extract was 1:

1.

2. The use according to claim 1, characterized in that The antibacterial repair composition is composed of the following components by weight: Collagen peptides: 1.5-2.5 parts; Centella asiatica extract: 4-6 parts; Yeast rice fermentation product filtrate: 1-2 parts; Gleditsia sinensis extract: 1-2 parts; Olive leaf extract: 1.5-3.5 parts; Propylene glycol: 15-20 parts; Water: 20-30 parts.

3. The use according to claim 1, characterized in that The preparation method of the antibacterial repair composition comprises: According to the proportion, collagen peptide, Centella asiatica extract, yeast rice fermentation product filtrate, Gleditsia sinensis extract, olive leaf extract, water and propylene glycol are stirred and heated to 40-50° C., and the antibacterial repair composition is obtained after mixing evenly.

4. The use according to claim 1, characterized in that The antibacterial repair composition is used for preparing sanitary products.

5. The use according to claim 1, characterized in that The antibacterial repair composition is used for preparing wet wipes.

6. The use according to claim 1, characterized in that The antibacterial repair composition is used for preparing sanitary napkins.

7. The use according to claim 6, characterized in that The sanitary napkin comprises: A sanitary napkin body and wings attached to both sides of the sanitary napkin body; The sanitary napkin body is composed of a cotton soft layer, an antibacterial layer, a water-absorbing layer, a bottom layer, a release paper and a film in sequence; wherein the antibacterial layer contains the antibacterial repair composition.

8. The use according to claim 7, characterized in that The water absorbing layer is made of mesh non-woven fabric.

9. The use according to claim 7, characterized in that The antibacterial layer is made of spunlace non-woven fabric.

10. The use according to claim 7, characterized in that The preparation method of the antibacterial layer comprises: mixing collagen peptide, Centella asiatica extract, yeast rice fermentation product filtrate, Gleditsia sinensis extract, olive leaf extract, water and propylene glycol in proportion, stirring and heating to 40-50° C., and mixing evenly to obtain an antibacterial repair composition; The spunlace nonwoven fabric is immersed in the antibacterial repair composition at 25-30° C. for 10-15 minutes and then dried.

11. The use according to claim 7, characterized in that The preparation method of the sanitary napkin comprises: After cutting to size, the cotton soft layer, the antibacterial layer, the water-absorbing layer, the bottom layer, the release paper and the wrapping film are bonded together in order to form the main body of the sanitary napkin; The wings are attached to both sides of the sanitary napkin body to obtain the sanitary napkin.