A synergistic compound sanitary insecticide composition and its application

Abstract

The invention discloses a synergistic compounding sanitary insecticide composition and its application, the total active ingredient content is 2%-70%, and the remainder is an adjuvant; the active ingredient is composed of active ingredient A and active ingredient B, active ingredient A is a piperic acid derivative compound, and active ingredient B is propoxur; the weight ratio of the weight ratio of active ingredients A and B is 15:1-1:15; the dosage form of the sanitary insecticide composition is a suspension, an oil suspension, a suspoemulsion, a microcapsule suspension-suspension, a dry suspension, a wettable powder and a water dispersible granule. The sanitary insecticide composition in the present invention has good environmental compatibility on the one hand, reduces the amount of pesticide used, and on the other hand, from the perspective of the mechanism of action, the mechanism of action of active ingredients A and B is different, there is no cross-resistance, and the prevention effect is improved, and the compounding of insecticides with different mechanisms of action of the two can also delay pest resistance, which is conducive to the resistance management of pests.

Description

Technical Field

[0001] The invention relates to a sanitary insecticide composition, in particular to a sanitary insecticide composition containing a piperic acid derivative compound and propoxur, wherein the effective ingredients are the piperic acid derivative compound and propoxur, and the composition belongs to the technical field of sanitary insecticide. Background Art

[0002] For a long time, residual spraying agents used against public health pests have mostly been single or compound formulations of pyrethroid products. The long-term use of pyrethroid agents has caused health pests such as mosquitoes, flies, and cockroaches to develop varying degrees of resistance to some pyrethroids, greatly reducing the control effect.

[0003] Chinese invention patent CN112457288 discloses a piperic acid derivative and its application, wherein compound I-72 has contact and stomach poison activity and good conduction activity, and can be used to control a variety of Lepidoptera, Hemiptera, Thysanoptera, Coleoptera and other pests. The compound has the following structural formula:

[0004]

[0005] Propoxur has contact and stomach poisoning effects and good knockdown activity. It has the dual characteristics of inhibiting acetylcholinesterase and acting on nerve axons.

[0006] The present invention has found through experiments that the compound I-72 and propoxur can solve the resistance problem. On the one hand, from the perspective of the mechanism of action, since the compound of the two does not have cross-resistance with the existing sanitary insecticides, the resistance problem of sanitary pests such as mosquitoes, flies, and cockroaches is solved, the prevention effect is improved, and the dosage is reduced; on the other hand, the irritation of compound I-72 and propoxur is small, which improves the safety of the pesticide applicators; and the compound of the two pesticides with different mechanisms of action can also delay the generation of pest resistance. At the same time, there has been no report on the compound composition of compound I-72 and pyrethroid insecticides so far. Summary of the invention

[0007] The technical problem to be solved by the present invention is to provide a synergistic compound sanitary insecticide composition and its application in view of the deficiencies in the prior art. The compound sanitary insecticide composition of the present invention has effective ingredients of a piperic acid derivative compound (compound I-72) and propoxur, has good environmental compatibility, is compounded with synergistic properties, is not prone to drug resistance, and has a long lasting effect.

[0008] In order to achieve the above object, the present invention adopts the following technical solution:

[0009] The present invention first provides a synergistic compound sanitary insecticide composition, wherein the active ingredients are composed of active ingredient A and active ingredient B, and the total weight of active ingredient A and active ingredient B accounts for 2% to 70% of the insecticide composition, and the balance is adjuvant;

[0010] The active ingredient A is a piperic acid derivative compound shown in formula I (referred to as compound I-72); the active ingredient B is propoxur;

[0011]

[0012] In the above technical scheme, the weight ratio of the piperic acid derivative compound (Compound I-72) to propoxur is 15:1 to 1:15, and the weight ratio is preferably 11:1 to 1:1.

[0013] In the above technical scheme, the sanitary insecticide composition is in the form of suspension, oil suspension, suspension emulsion, microcapsule suspension-suspension, dry suspension, wettable powder and water dispersible granules.

[0014] In the above technical scheme, the auxiliary agent is a mixture of three or more of wetting agent, dispersant, antifreeze agent, preservative, defoamer, thickener, disintegrant, emulsifier, polymer capsule wall material, filler, solvent, deionized water, sustained-release agent and palatant in any proportion.

[0015] In the above technical scheme, the sanitary insecticide composition, when in the form of a suspension, comprises the following raw materials in weight percentage: 1-40% of a piperic acid derivative compound, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 3-7% of an antifreeze agent, 0.3-2% of a preservative, 0.1-1% of a defoaming agent, 0.5-3% of a thickener, 1-10% of a sustained-release agent, 1-10% of a palatant, and deionized water is added to 100%.

[0016] In the above technical scheme, the sanitary insecticide composition, when in the form of an oil suspension, comprises the following raw materials in weight percentage: 1-25% of a piperic acid derivative compound, 1-10% of propoxur, 0.2-1% of a wetting agent, 0.3-3% of a dispersant, 2-6% of an emulsifier, 0.2-5% of a defoaming agent, 0.2-5% of a thickener, 1-10% of a sustained-release agent, and 1-10% of a palatant, and the solvent is supplemented to 100%.

[0017] In the above technical scheme, the sanitary insecticide composition, when in the form of a suspension emulsion, comprises the following percentages of raw materials: 1-20% of piperic acid derivative compounds, 1-10% of propoxur, 1-8% of wetting agents, 1-8% of dispersants, 1-10% of solvents, 1-8% of emulsifiers, 3-7% of antifreeze agents, 0.3-2% of preservatives, 0.1-1% of defoamers, 0.5-3% of thickeners, 1-10% of sustained-release agents, 1-10% of palatants, and deionized water is added to 100%.

[0018] In the above technical scheme, the sanitary insecticide composition, when the dosage form is a microcapsule suspension-suspension concentrate, comprises the following percentages of raw materials: 1-40% of piperic acid derivative compounds, 1-10% of propoxur, 3-6% of polymer capsule wall materials, 3-8% of wetting agents, 2-10% of dispersants, 1-5% of solvents, 1-6% of emulsifiers, 0.2-5% of defoamers, 0.2-5% of thickeners, 1-10% of sustained-release agents, 1-10% of palatants, and deionized water is supplemented to 100%.

[0019] In the above technical scheme, the sanitary insecticide composition, when in the form of a dry suspension, comprises the following raw materials in weight percentage: 1-50% of a piperic acid derivative compound, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 1-10% of a sustained-release agent, 1-10% of a palatant, and the filler is supplemented to 100%.

[0020] In the above technical scheme, the sanitary insecticide composition, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 1-60% of a piperic acid derivative compound, 1-10% of propoxur, 2-6% of a wetting agent, 7-18% of a dispersant, 1-10% of a sustained-release agent, 1-10% of a palatant, and the filler is supplemented to 100%.

[0021] In the above technical scheme, the sanitary insecticide composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 1-60% of piperic acid derivative compounds, 1-10% of propoxur, 2-15% of wetting agents, 5-20% of dispersants, 2-8% of disintegrants, 1-10% of sustained-release agents, 1-10% of palatants, and the fillers are supplemented to 100%.

[0022] In the above technical scheme, the wetting agent is selected from any one of sodium naphthalenesulfonate, sodium dodecyl sulfate, pull-opening powder BX, alkylphenol polyoxyethylene ether formaldehyde condensate sodium sulfate, alkylbenzene polyoxyethylene ether phosphate, phenethylphenol polyoxyethylene ether phosphate, alkyl sodium sulfate, alkyl sodium sulfonate, and dodecylbenzene sulfonic acid, or a mixture of two or more in any proportion.

[0023] In the above technical scheme, the dispersant is selected from any one of sodium polycarboxylate, sodium lignin sulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate, sodium naphthalenesulfonic acid formaldehyde condensate, non-ionic hydroxy polyethylene oxide block copolymer, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester, and glycerol fatty acid ester polyoxyethylene ether, or a mixture of two or more in any proportion.

[0024] In the above technical solution, the antifreeze agent is selected from any one of ethylene glycol, propylene glycol, glycerol, glycerin, and urea, or a mixture of two or more of them in any proportion.

[0025] In the above technical solution, the preservative is selected from any one of sodium benzoate, benzoic acid, potassium sorbate, and kasone, or a mixture of two or more of the above in any proportion.

[0026] In the above technical solution, the defoaming agent is selected from any one of polydimethylsiloxane, silicone oil, glyceryl ricinoleate, distearyl ethylenediamine, or a mixture of two or more in any proportion.

[0027] In the above technical solution, the thickener is selected from any one of xanthan gum, hydroxymethyl cellulose, hydroxyethyl cellulose, and magnesium aluminum silicate, or a mixture of two or more of the above in any proportion.

[0028] In the above technical solution, the disintegrant is selected from any one of sodium chloride, ammonium sulfate, sodium carbonate, sodium bicarbonate, and sodium sulfate, or a mixture of two or more of them in any proportion.

[0029] In the above technical scheme, the emulsifier is selected from any one of calcium dodecylbenzene sulfonate, nonylphenol polyoxyethylene ether, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, Span 60, Span 80, Tween 60, Tween 80, fatty alcohol polyoxyethylene ether, styrylphenol polyoxyethylene ether, alkylaryl polyoxyethylene ether polyoxypropylene ether, or a mixture of two or more in any proportion.

[0030] In the above technical solution, the polymer capsule wall material is selected from any one of urea-formaldehyde resin, polyisocyanate, polyamide, or a mixture of the two in any proportion.

[0031] In the above technical solution, the filler is selected from any one of kaolin, white carbon black, corn starch, attapulgite, calcium carbonate, light calcium, diatomaceous earth, and bentonite, or a mixture of two or more of them in any proportion.

[0032] In the above technical scheme, the solvent is selected from any one of N,N-dimethylformamide, N,N-dimethylacetamide, N,N-dimethylbutyl amide, xylene, ethanol, soybean oil, methyl oleate, corn oil, rapeseed oil, and dodecane, or a mixture of two or more in any proportion.

[0033] In the above technical solution, the sustained-release agent is selected from any one of methyl cellulose, modified starch, gum arabic, and polyvinyl alcohol, or a mixture of two or more of them in any proportion.

[0034] In the above technical solution, the palatant is selected from any one of maltose, sucrose, lactose, and protein sugar, or a mixture of two or more of them in any proportion.

[0035] In the above technical scheme, when the sanitary insecticide composition is in the form of suspension, oil suspension, suspension emulsion, suspension-microcapsule suspension, dry suspension, water dispersible granules and wettable powder, it can be prepared according to conventional methods or existing methods in the art.

[0036] The invention also provides an application of the sanitary insecticide composition in preventing and controlling sanitary pests.

[0037] In the above technical scheme, the sanitary pests refer to Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Aedes harassingus, Chironomids, Housefly, Chrysopa longituba, Lucilia sericata, Lucilia cuprina, Lucilia brighten, Summer toilet fly, Meta toilet fly, German cockroach, American cockroach, Bed bug, Human flea, Ixodes persulcatus, Ixodes sinensis, Ixodes prairies, Boophilus microplus, Gamas and scabies.

[0038] In the above technical scheme, the sanitary insecticide composition is used to control sanitary pests by residual spraying: the sanitary insecticide composition is diluted 50-300 times with water and then sprayed on surfaces such as walls, doors, windows, ceilings and homes, so that the sanitary insecticide remains on the surfaces of the above objects, knocking down and killing the sanitary pests.

[0039] Compared with the prior art, the composition of the present invention adopts two insecticides with different action mechanisms to improve the prevention effect and delay the generation of resistance, thus providing a new method for preventing and controlling sanitary pests. DETAILED DESCRIPTION

[0040] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0041] The preparation method of the dosage form in each embodiment of the present invention is as follows:

[0042] The laboratory preparation method of the suspension concentrate is as follows: weigh the wetting agent, dispersant, antifreeze, preservative, defoamer, slow-release agent, and deionized water according to the ratio, add them into a beaker and mix them evenly, then add cyantraniliprole and neonicotinoid insecticides into the beaker, and then transfer it to a sand mill, add zirconium oxide beads into the sand mill, grind for 2-3 hours, add thickener and continue grinding for 0.5 hours, and make the particle size D 95 The product can be obtained by controlling the particle size below 5 microns and filtering to remove the zirconium oxide beads.

[0043] The laboratory preparation method of the oil suspension is as follows: weigh the dispersant, wetting agent, emulsifier, defoamer, slow-release agent and solvent according to the proportion, add them into a beaker and mix them evenly, then add cyantraniliprole and neonicotinoid insecticides into the beaker, and then transfer it to a sand mill, add zirconium oxide beads into the sand mill, grind for 2-3 hours, add thickener and continue grinding for 0.5 hours, and make the particle size D95 The product can be obtained by controlling the particle size below 5 microns and filtering to remove the zirconium oxide beads.

[0044] The laboratory preparation method of the suspension emulsion is as follows: weigh the wetting agent, dispersant, preservative, and sustained-release agent according to the ratio, add them into a beaker, mix them evenly with part of the deionized water, add cyantraniliprole or neonicotinoid insecticide into the beaker, and then transfer it to a sand mill, add zirconium oxide beads into the sand mill, grind for 2-3 hours, add thickener and continue grinding for 0.5 hours to make the particle size D 95 The concentration is controlled below 5 microns, and the zirconium oxide beads are filtered to remove the cyantraniliprole suspension or neonicotinoid insecticide suspension. The cyantraniliprole or neonicotinoid insecticide, solvent and emulsifier are dissolved into an oil phase, and the antifreeze, defoamer and remaining deionized water form an aqueous phase. Under high-speed shear, the aqueous phase is added to the oil phase or the oil phase is added to the aqueous phase to obtain the cyantraniliprole aqueous emulsion or neonicotinoid insecticide aqueous emulsion. Then, the cyantraniliprole suspension and the neonicotinoid insecticide aqueous emulsion or the cyantraniliprole aqueous emulsion and the neonicotinoid insecticide suspension are evenly mixed to obtain a suspension emulsion.

[0045] The laboratory preparation method of microcapsule suspension-suspension concentrate is as follows: cyantraniliprole or neonicotinoid insecticide, polymer capsule wall material, and solvent are weighed in proportion to dissolve into oil phase, emulsifier, dispersant, sustained-release agent and part of deionized water are weighed in proportion to form water phase, and the water phase is added to the oil phase or the oil phase is added to the water phase under high-speed shearing to obtain cyantraniliprole microcapsule suspension or neonicotinoid insecticide microcapsule suspension. Weigh the wetting agent, defoamer, thickener, antifreeze agent and remaining deionized water in proportion, add them to a beaker and mix them evenly, then add cyantraniliprole or neonicotinoid insecticide to the beaker, and then transfer it to a sand mill, add zirconium oxide beads to the sand mill, grind for 2-3 hours, add thickener and continue grinding for 0.5 hours to make the particle size D 95 The concentration of cyantraniliprole suspension or neonicotinoid insecticide suspension can be obtained by controlling the concentration below 5 microns and filtering to remove the zirconium oxide beads. Then, the cyantraniliprole microcapsule suspension and the neonicotinoid insecticide suspension or the cyantraniliprole suspension and the neonicotinoid insecticide microcapsule suspension are uniformly mixed to obtain a microcapsule suspension-suspension concentrate.

[0046] The laboratory preparation method of the dry suspension concentrate is as follows: weigh the wetting agent, dispersant, filler, slow-release agent, palatant and water according to the proportion, add them into a beaker and mix them evenly, then add cyantraniliprole and neonicotinoid insecticides into the beaker, and then transfer it to a sand mill, add zirconium oxide beads into the sand mill, grind for 2-3 hours, and make the particle size D 95 The particle size is controlled below 5 microns, the zirconium oxide beads are removed by filtration, and the obtained material is dried by a spray dryer to obtain the product.

[0047] The laboratory preparation method of wettable powder is as follows: compound I-72, propoxur, wetting agent, dispersant, sustained-release agent, palatant and filler are weighed according to the ratio, added into a food processor and mixed evenly, and then put into a jet mill for grinding to obtain the wettable powder.

[0048] The laboratory preparation method of water-dispersible granules is as follows: compound I-72, propoxur, wetting agent, dispersant, disintegrant, sustained-release agent, palatant and filler are weighed according to the ratio, added into a food processor and mixed evenly, then put into a jet mill for grinding, mixed again with a food processor, added with an appropriate amount of water, extruded into granules with a granulator, and dried in an oven at 45°C.

[0049] The present invention will be described below in conjunction with specific embodiments:

[0050] Formulation Example 1: 21% Compound I-72·Propoxur Suspension

[0051] 18% of compound I-72, 3% of propoxur, 1% of sodium naphthalenesulfonate, 8% of sodium polycarboxylate, 3% of ethylene glycol, 0.3% of sodium benzoate, 0.1% of polydimethylsiloxane, 3% of xanthan gum, 1% of methylcellulose, 1% of maltose, and deionized water is added to make up to 100%.

[0052] Formulation Example 2: 16% Compound I-72·Propoxur Suspension

[0053] 15% of compound I-72, 1% of propoxur, 3% of sodium dodecyl sulfate, 5% of sodium lignin sulfonate, 4% of propylene glycol, 1% of benzoic acid, 0.4% of silicone oil, 2.5% of hydroxymethyl cellulose, 4% of modified starch, 2% of sucrose, and deionized water is added to 100%.

[0054] Formulation Example 3: 10% Compound I-72·Propoxur Suspension

[0055] 5% of compound I-72, 5% of propoxur, 5% of lakai powder BX, 3% of alkylphenol polyoxyethylene ether formaldehyde condensate, 6% of glycerol, 1.5% of potassium sorbate, 0.7% of glyceryl ricinoleate, 1.5% of hydroxyethyl cellulose, 7% of gum arabic, 3% of lactose, and deionized water is added to 100%.

[0056] Formulation Example 4: 12% Compound I-72·Propoxur Suspension

[0057] 2% compound I-72, 10% propoxur, 8% sodium sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, 1% sodium naphthalenesulfonic acid formaldehyde condensate, 7% glycerol, 2% kason, 1% distearyl ethylenediamine, 0.5% magnesium aluminum silicate, 10% polyvinyl alcohol, 4% protein sugar, and deionized water is supplemented to 100%.

[0058] Formulation Example 5: 21% Compound I-72·Propoxuryl Oil Suspension

[0059] 18% of compound I-72, 3% of propoxur, 0.2% of alkylbenzene polyoxyethylene ether phosphate, 3% of non-ionic hydroxy polyethylene oxide block copolymer, 6% of calcium dodecylbenzene sulfonate, 0.2% of polydimethylsiloxane, 5% of xanthan gum, 1% of methyl cellulose, 5% of protein sugar, and methyl oleate is supplemented to 100%.

[0060] Formulation Example 6: 27% Compound I-72·Propoxuryl Oil Suspension

[0061] 25% of compound I-72, 2% of propoxur, 0.5% of phenethylphenol polyoxyethylene ether phosphate, 1.5% of fatty amine polyoxyethylene ether, 5% of nonylphenol polyoxyethylene ether, 2% of silicone oil, 3% of hydroxymethyl cellulose, 4% of modified starch, 6% of lactose, and corn oil is supplemented to 100%.

[0062] Formulation Example 7: 20% Compound I-72·Propoxuryl Oil Suspension

[0063] 10% of compound I-72, 10% of propoxur, 0.8% of sodium alkyl sulfate, 1% of polyoxyethylene fatty acid esters, 3% of alkylphenol polyoxyethylene ethers, 3% of glyceryl ricinoleate, 2% of hydroxyethyl cellulose, 7% of gum arabic, 7% of sucrose, and rapeseed oil is supplemented to 100%.

[0064] Formulation Example 8: 8% Compound I-72·Propoxuryl Oil Suspension

[0065] 2% of compound I-72, 6% of propoxur, 1% of sodium alkyl sulfonate, 0.3% of glycerol fatty acid ester polyoxyethylene ether, 2% of castor oil polyoxyethylene ether, 5% of glycerol ricinoleate, 0.2% of magnesium aluminum silicate, 10% of polyvinyl alcohol, 8% of maltose, and dodecane is supplemented to 100%.

[0066] Formulation Example 9: 21% Compound I-72·Propoxur suspension emulsion

[0067] 18% of compound I-72, 3% of propoxur, 1% of phenethylphenol polyoxyethylene ether phosphate, 8% of non-ionic hydroxypolyethylene oxide block copolymer, 1% of N,N-dimethylformamide, 8% of Span 60, 3% of propylene glycol, 0.3% of sodium benzoate, 1% of polydimethylsiloxane, 3% of xanthan gum, 10% of methylcellulose, 9% of maltose, and deionized water is added to 100%.

[0068] Formulation Example 10: 22% Compound I-72·Propoxur suspension emulsion

[0069] 20% compound I-72, 2% propoxur, 3% sodium alkyl sulfate, 5% fatty amine polyoxyethylene ether, 4% N,N-dimethylacetamide, 6% Span 80, 3% glycerol, 0.3% benzoic acid, 1% silicone oil, 3% hydroxymethyl cellulose, 1% modified starch, 10% sucrose, and deionized water is added to 100%.

[0070] Formulation Example 11: 18% Compound I-72·Propoxur suspension emulsion

[0071] 9% compound I-72, 9% propoxur, 5% sodium alkyl sulfonate, 3% polyoxyethylene fatty acid ester, 7% N,N-dimethyltaurate, 4% Tween 60, 7% glycerol, 2% potassium sorbate, 0.1% silicone oil, 0.5% hydroxyethyl cellulose, 10% gum arabic, 1% maltose, 9% sucrose, and deionized water is added to 100%.

[0072] Formulation Example 12: 12% Compound I-72·Propoxur suspension emulsion

[0073] 3% compound I-72, 9% propoxur, 8% dodecylbenzenesulfonic acid, 1% glycerol fatty acid ester polyoxyethylene ether, 10% xylene, 1% Tween 80, 7% urea, 2% kason, 0.1% polydimethylsiloxane, 0.5% magnesium aluminum silicate, 1% polyvinyl alcohol, 3% maltose, 1% sucrose, and deionized water is added to 100%.

[0074] Formulation Example 13: 21% Compound I-72·Propoxur Microcapsule Suspension-Suspension Concentrate

[0075] 18% compound I-72, 3% propoxur, 3% polyisocyanate, 8% phenethylphenol polyoxyethylene ether phosphate, 2% non-ionic hydroxy polyethylene oxide block copolymer, 3% ethanol, 1% Tween 80, 3% polydimethylsiloxane, 3% magnesium aluminum silicate, 10% polyvinyl alcohol, 2% lactose, 3% protein sugar, and deionized water is supplemented to 100%.

[0076] Preparation Example 14: 44% Compound I-72·Propoxur Microcapsule Suspension-Suspension

[0077] 40% compound I-72, 4% propoxur, 4% urea-formaldehyde resin, 3% sodium alkyl sulfate, 5% fatty amine polyoxyethylene ether, 5% soybean oil, 4% fatty alcohol polyoxyethylene ether, 5% silicone oil, 0.2% hydroxyethyl cellulose, 5% gum arabic, 5% lactose, and deionized water is added to 100%.

[0078] Formulation Example 15: 30% Compound I-72·Propoxur Microcapsule Suspension-Suspension

[0079] 20% of compound I-72, 10% of propoxur, 5% of polyamide, 8% of sodium alkyl sulfonate, 8% of polyoxyethylene fatty acid esters, 3% of methyl oleate, 6% of polyoxyethylene styrylphenol ether, 3% of glycerol ricinoleate, 3% of hydroxymethyl cellulose, 1% of modified starch, 3% of protein sugar, and deionized water is added to make up to 100%.

[0080] Formulation Example 16: 10% Compound I-72·Propoxur Microcapsule Suspension-Suspension

[0081] 2% compound I-72, 8% propoxur, 6% urea-formaldehyde resin, 3% dodecylbenzenesulfonic acid, 10% glycerol fatty acid ester polyoxyethylene ether, 1% corn oil, 4% alkylaryl polyoxyethylene ether polyoxypropylene ether, 0.2% distearylethylenediamine, 5% xanthan gum, 5% methyl cellulose, 3% lactose, and deionized water is supplemented to 100%.

[0082] Formulation Example 17: 21% Compound I-72·Propoxur dry suspension

[0083] 18% of compound I-72, 3% of propoxur, 1% of phenethylphenol polyoxyethylene ether phosphate, 8% of sodium naphthalenesulfonic acid formaldehyde condensate, 1% of polyvinyl alcohol, 3% of maltose, and kaolin is added to 100%.

[0084] Preparation Example 18: 55% Compound I-72·Propoxur dry suspension

[0085] 50% of compound I-72, 5% of propoxur, 3% of sodium alkyl sulfate, 5% of alkylphenol polyoxyethylene ether formaldehyde condensate, 4% of gum arabic, 3% of sucrose, and corn starch is supplemented to 100%.

[0086] Formulation Example 19: 30% Compound I-72·Propoxur dry suspension

[0087] 20% of compound I-72, 10% of propoxur, 5% of sodium alkyl sulfonate, 3% of sodium lignin sulfonate, 7% of modified starch, 4% of lactose, and attapulgite is added to make up to 100%.

[0088] Formulation Example 20: 12% Compound I-72·Propoxur dry suspension

[0089] 2% of compound I-72, 10% of propoxur, 8% of dodecylbenzenesulfonic acid, 1% of sodium polycarboxylate, 10% of methylcellulose, 5% of protein sugar, and calcium carbonate is added to 100%.

[0090] Formulation Example 21: 21% Compound I-72·Propoxur Wettable Powder

[0091] 18% of compound I-72, 3% of propoxur, 2% of sodium naphthalenesulfonate, 18% of sodium polycarboxylate, 1% of polyvinyl alcohol, 6% of sucrose, and kaolin is added to make up to 100%.

[0092] Formulation Example 22: 65% Compound I-72·Propoxur Wettable Powder

[0093] 60% of compound I-72, 5% of propoxur, 3% of sodium dodecyl sulfate, 14% of sodium lignin sulfonate, 3% of gum arabic, 6% of lactose, 10% of white carbon black, and corn starch to make up to 100%.

[0094] Formulation Example 23: 30% Compound I-72·Propoxur Wettable Powder

[0095] 20% of compound I-72, 10% of propoxur, 5% of lakai powder BX, 11% of alkylphenol polyoxyethylene ether formaldehyde condensate, 7% of modified starch, 6% of lactose, and attapulgite is supplemented to 100%.

[0096] Formulation Example 24: 13% Compound I-72·Propoxur Wettable Powder

[0097] 3% of compound I-72, 9% of propoxur, 6% of sodium sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, 7% of sodium naphthalenesulfonic acid formaldehyde condensate, 10% of methyl cellulose, 1% of maltose, and kaolin is supplemented to 100%.

[0098] Formulation Example 25: 21% Compound I-72·Propoxur Water Dispersible Granules

[0099] 18% of compound I-72, 3% of propoxur, 2% of alkylbenzene polyoxyethylene ether phosphate, 20% of nonionic hydroxy polyethylene oxide block copolymer, 2% of sodium sulfate, 10% of methyl cellulose, 10% of lactose, and bentonite is supplemented to 100%.

[0100] Formulation Example 26: 64% Compound I-72·Propoxur Water Dispersible Granules

[0101] 60% of compound I-72, 4% of propoxur, 6% of phenethylphenol polyoxyethylene ether phosphate, 15% of fatty amine polyoxyethylene ether, 2% of sodium carbonate, 2% of sodium bicarbonate, 5% of modified starch, 1% of maltose, 1% of protein sugar, and diatomaceous earth is added to make up to 100%.

[0102] Formulation Example 27: 30% Compound I-72·Propoxur Water Dispersible Granules

[0103] 20% of compound I-72, 10% of propoxur, 10% of sodium alkyl sulfate, 10% of polyoxyethylene fatty acid esters, 6% of ammonium sulfate, 5% of gum arabic, 2% of maltose, 1% of sucrose, and light calcium supplemented to 100%.

[0104] Formulation Example 28: 20% Compound I-72·Propoxur Water Dispersible Granules

[0105] 10% compound I-72, 10% propoxur, 10% sodium alkyl sulfonate, 5% dodecylbenzenesulfonic acid, 4% fatty acid polyoxyethylene esters, 1% glycerol fatty acid ester polyoxyethylene ether, 8% sodium chloride, 1% polyvinyl alcohol, 2% sucrose, 1% protein sugar, and calcium carbonate is supplemented to 100%.

[0106] Formulation Example 29: 50% Compound I-72·Propoxur Suspension

[0107] 40% of compound I-72, 10% of propoxur, 1% of sodium naphthalenesulfonate, 8% of sodium polycarboxylate, 3% of ethylene glycol, 0.3% of sodium benzoate, 0.1% of polydimethylsiloxane, 3% of xanthan gum, 1% of methylcellulose, 1% of maltose, and deionized water is added to make up to 100%.

[0108] Formulation Example 30: 35% Compound I-72·Propoxuryl Oil Suspension

[0109] 25% of compound I-72, 10% of propoxur, 0.2% of alkylbenzene polyoxyethylene ether phosphate, 3% of non-ionic hydroxy polyethylene oxide block copolymer, 6% of calcium dodecylbenzene sulfonate, 0.2% of polydimethylsiloxane, 5% of xanthan gum, 1% of methyl cellulose, 5% of protein sugar, and methyl oleate is supplemented to 100%.

[0110] Formulation Example 31: 30% Compound I-72·Propoxur suspension emulsion

[0111] 20% of compound I-72, 10% of propoxur, 1% of phenethylphenol polyoxyethylene ether phosphate, 8% of non-ionic hydroxypolyethylene oxide block copolymer, 1% of N,N-dimethylformamide, 8% of Span 60, 3% of propylene glycol, 0.3% of sodium benzoate, 1% of polydimethylsiloxane, 3% of xanthan gum, 10% of methylcellulose, 9% of maltose, and deionized water is added to 100%.

[0112] Formulation Example 32: 50% Compound I-72·Propoxur Microcapsule Suspension-Suspension

[0113] 40% of compound I-72, 10% of propoxur, 3% of polyisocyanate, 8% of phenethylphenol polyoxyethylene ether phosphate, 2% of non-ionic hydroxy polyethylene oxide block copolymer, 3% of ethanol, 1% of Tween 80, 3% of polydimethylsiloxane, 3% of magnesium aluminum silicate, 1% of polyvinyl alcohol, 2% of lactose, 3% of protein sugar, and deionized water is added to 100%.

[0114] Preparation Example 33: 60% Compound I-72·Propoxur dry suspension

[0115] 50% of compound I-72, 10% of propoxur, 1% of phenethylphenol polyoxyethylene ether phosphate, 8% of sodium naphthalenesulfonic acid formaldehyde condensate, 1% of polyvinyl alcohol, 3% of maltose, and kaolin is added to 100%.

[0116] Formulation Example 34: 70% Compound I-72·Propoxur Wettable Powder

[0117] 60% of compound I-72, 10% of propoxur, 2% of sodium naphthalenesulfonate, 7% of sodium polycarboxylate, 1% of polyvinyl alcohol, 1% of sucrose, and kaolin is added to make up to 100%.

[0118] Formulation Example 35: 70% Compound I-72·Propoxur Water Dispersible Granules

[0119] 60% of compound I-72, 10% of propoxur, 2% of alkylbenzene polyoxyethylene ether phosphate, 7% of nonionic hydroxy polyethylene oxide block copolymer, 2% of sodium sulfate, 1% of methyl cellulose, 1% of lactose, and bentonite is supplemented to 100%.

[0120] Application Example 1: Co-toxicity coefficient of compound I-72 and propoxur against Culex pipiens pallens

[0121] Test subjects: Culex pipiens pallens (laboratory breeding); Test methods: Refer to the first part of the pesticide indoor bioassay test guidelines for insecticides: contact activity test, and use the drip method NY / T1154.1-2006 to conduct activity determination tests on Culex pipiens pallens; Data statistics: The co-toxicity coefficient method is used to evaluate the activity of the combination of the two against Culex pipiens pallens. Then use DPS statistical software to calculate the LD50 value of each drug, and then calculate the toxicity index and co-toxicity coefficient of the agent according to Sun Yunpei's method. A co-toxicity coefficient greater than 120 indicates a synergistic effect, a co-toxicity coefficient between 80-120 indicates an additive effect, and a co-toxicity coefficient less than 80 indicates an antagonistic effect. The test results are shown in the following table:

[0122] Table 1 Co-toxicity coefficient of compound I-72 and propoxur to Culex pipiens pallens

[0123]

[0124] It can be seen from Table 1 that the co-toxicity coefficient of compound I-72: propoxur at a ratio of 11:1 to 1:1 is greater than 120, which is a synergistic effect.

[0125] Application Example 2: Experiment on the efficacy of drugs for preventing and controlling mosquitoes and flies

[0126] Test subjects: Culex pipiens and housefly (laboratory reared);

[0127] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spray test;

[0128] Control 1: 21% Compound I-72 suspension

[0129] 21% of compound I-72, 1% of sodium naphthalenesulfonate, 8% of sodium polycarboxylate, 3% of ethylene glycol, 0.3% of sodium benzoate, 0.1% of polydimethylsiloxane, 3% of xanthan gum, 1% of methylcellulose, 1% of maltose, and deionized water is added to 100%.

[0130] Control 2: 21% Propoxur SC

[0131] 21% propoxur, 1% sodium naphthalenesulfonate, 8% sodium polycarboxylate, 3% ethylene glycol, 0.3% sodium benzoate, 0.1% polydimethylsiloxane, 3% xanthan gum, 1% methylcellulose, 1% maltose, and deionized water is added to make up to 100%.

[0132] Control sample 3: 32% compound I-72·Propoxur SC

[0133] 30% of compound I-72, 2% of propoxur, 1% of sodium naphthalenesulfonate, 8% of sodium polycarboxylate, 3% of ethylene glycol, 0.3% of sodium benzoate, 0.1% of polydimethylsiloxane, 3% of xanthan gum, 1% of methylcellulose, 1% of maltose, and deionized water is added to 100%.

[0134] Control sample 4: 21% compound I-72·propoxur wettable powder

[0135] 21% of compound I-72, 2% of sodium naphthalenesulfonate, 18% of sodium polycarboxylate, 1% of polyvinyl alcohol, 6% of sucrose, and kaolin to 100%.

[0136] Control sample 5: 21% compound I-72·propoxur wettable powder

[0137] 21% propoxur, 2% sodium naphthalenesulfonate, 18% sodium polycarboxylate, 1% polyvinyl alcohol, 6% sucrose, kaolin to make up to 100%.

[0138] Control sample 6: 64% compound I-72·propoxur wettable powder

[0139] 60% of compound I-72, 4% of propoxur, 2% of sodium naphthalenesulfonate, 18% of sodium polycarboxylate, 1% of polyvinyl alcohol, 6% of sucrose, and kaolin is added to make up to 100%.

[0140] Control sample 7: 10% perchlorpromazine·propoxur suspension (commercially available)

[0141] Control sample 8: 15% cischlorfenapyr suspension (commercially available)

[0142] Test treatment: The preparation examples and control agents were diluted to 1000 ppm according to the total concentration of active ingredients;

[0143] Test results:

[0144] Table 5 Residual spraying efficacy test of some formulation examples against Culex pipiens pallens and housefly

[0145]

[0146]

[0147] As can be seen from Table 5, the combination of compound I-72 and propoxur has a significant synergistic effect on the knockdown and lethality of mosquitoes and flies, and compared with commercially available products, the knockdown and lethality of the present invention against mosquitoes and flies are higher. When the weight ratio of compound I-72 to propoxur is within the preferred range, the synergistic effect is more obvious.

[0148] Application Example 3: Sustained Release Agent Efficacy Test

[0149] Test target: Culex pipiens pallens, female adults that have not fed blood on the 3rd to 5th day after emergence;

[0150] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spray test;

[0151] Control sample 9: 21% compound I-72·propoxur suspension emulsion

[0152] 18% of compound I-72, 3% of propoxur, 1% of phenethylphenol polyoxyethylene ether phosphate, 8% of non-ionic hydroxypolyethylene oxide block copolymer, 1% of N,N-dimethylformamide, 8% of Span 60, 3% of propylene glycol, 0.3% of sodium benzoate, 1% of polydimethylsiloxane, 3% of xanthan gum, and deionized water is added to 100%.

[0153] Control sample 10: 21% compound I-72·propoxur dry suspension

[0154] 18% of compound I-72, 3% of propoxur, 1% of phenethylphenol polyoxyethylene ether phosphate, 8% of sodium naphthalenesulfonic acid formaldehyde condensate, and kaolin is added to make up to 100%.

[0155] Control sample 11: 21% compound I-72·propoxur water dispersible granules

[0156] 18% of compound I-72, 3% of propoxur, 2% of alkylbenzene polyoxyethylene ether phosphate, 20% of nonionic hydroxy polyethylene oxide block copolymer, 2% of sodium sulfate, and bentonite makes up to 100%.

[0157] Test treatment: The preparation examples and control agents were diluted to 1000 ppm according to the total concentration of active ingredients;

[0158] Test results:

[0159] Table 6 Sustained-release and sustained-effect test of some formulation examples against mosquitoes and flies

[0160]

[0161] As can be seen from Table 6, after being exposed to air and stored for 15 days, the formulation examples 9, 17, and 25 still have a good knockdown effect on mosquitoes and flies, the efficacy decreases slowly, and the duration of efficacy is long. However, after 15 days, the efficacy of the control samples 9, 10, and 11 (no sustained-release agent is added to the formula) decreases rapidly, the knockdown rate is significantly slowed down, and the mortality rate is significantly reduced.

[0162] Application Example 4: Palatant Effect Test

[0163] Test target: Culex pipiens pallens, female adults that have not fed blood on the 3rd to 5th day after emergence;

[0164] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spray test;

[0165] Control 12: 21% Compound I-72·Propoxuryl oil suspension

[0166] 18% of compound I-72, 3% of propoxur, 0.2% of alkylbenzene polyoxyethylene ether phosphate, 3% of non-ionic hydroxy polyethylene oxide block copolymer, 6% of calcium dodecylbenzene sulfonate, 0.2% of polydimethylsiloxane, 5% of xanthan gum, 1% of methyl cellulose, and methyl oleate is supplemented to 100%.

[0167] Control sample 13: 21% compound I-72·Propoxur microcapsule suspension-suspension concentrate

[0168] 18% of compound I-72, 3% of propoxur, 3% of polyisocyanate, 8% of phenethylphenol polyoxyethylene ether phosphate, 2% of non-ionic hydroxy polyethylene oxide block copolymer, 3% of ethanol, 1% of Tween 80, 3% of polydimethylsiloxane, 3% of magnesium aluminum silicate, 10% of polyvinyl alcohol, and deionized water is added to 100%.

[0169] Test treatment: The preparation examples and control agents were diluted to 1000 ppm according to the total concentration of active ingredients;

[0170] Test results:

[0171] Table 7: Efficacy test of palatants against mosquitoes and flies in some formulation examples

[0172]

[0173] As can be seen from Table 7, the knockdown and lethality of formulation examples 5 and 13 against mosquitoes and flies are significantly improved after adding palatants, and compared with commercially available products, the knockdown and lethality of the present invention against mosquitoes and flies are higher.

[0174] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A synergistic compound sanitary insecticide composition, characterized in that: The active ingredients are composed of active ingredient A and active ingredient B, and the total weight of active ingredient A and active ingredient B accounts for 2%-70% of the insecticide composition by weight, and the balance is adjuvants; wherein active ingredient A is a piperic acid derivative compound shown in formula I, and active ingredient B is propoxur; the weight ratio of active ingredients A to B is 11:1 to 1:1; the hygienic insecticide composition is in the form of a suspension concentrate, an oil suspension concentrate, a suspension emulsion, a microcapsule suspension-suspension concentrate, a dry suspension concentrate, a wettable powder or a water-dispersible granule; Formula I.

2. The sanitary insecticidal composition according to claim 1, characterized in that When the dosage form of the sanitary insecticide composition is a suspension, it includes the following raw materials in weight percentage: 1-40% of piperic acid derivative compounds, 1-10% of propoxur, 1-8% of wetting agent, 1-8% of dispersant, 3-7% of antifreeze agent, 0.3-2% of preservative, 0.1-1% of defoaming agent, 0.5-3% of thickener, 1-10% of sustained-release agent, 1-10% of palatant, and deionized water is supplemented to 100%.

3. The sanitary insecticidal composition according to claim 1, characterized in that When the sanitary insecticide composition is in the form of an oil suspension, it comprises the following raw materials in weight percentage: 1-25% of a piperic acid derivative compound, 1-10% of propoxur, 0.2-1% of a wetting agent, 0.3-3% of a dispersant, 2-6% of an emulsifier, 0.2-5% of a defoaming agent, 0.2-5% of a thickener, 1-10% of a sustained-release agent, and 1-10% of a palatant, and the solvent is supplemented to 100%.

4. The sanitary insecticidal composition according to claim 1, characterized in that The sanitary insecticide composition, when in the form of a suspended emulsion, comprises the following raw materials in percentages: 1-20% of a piperic acid derivative compound, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 1-8% of an emulsifier, 1-10% of a solvent, 3-7% of an antifreeze agent, 0.3-2% of a preservative, 0.1-1% of a defoaming agent, 0.5-3% of a thickener, 1-10% of a sustained-release agent, 1-10% of a palatant, and deionized water is added to make up to 100%.

5. The sanitary insecticidal composition according to claim 1, characterized in that: The sanitary insecticide composition, when in the form of a microcapsule suspension-suspension concentrate, comprises the following raw materials in percentages: 1-40% of piperic acid derivative compounds, 1-10% of propoxur, 3-6% of polymer capsule wall materials, 3-8% of wetting agents, 2-10% of dispersants, 1-5% of solvents, 1-6% of emulsifiers, 0.2-5% of defoamers, 0.2-5% of thickeners, 1-10% of sustained-release agents, 1-10% of palatants, and deionized water is added to 100%.

6. The sanitary insecticidal composition according to claim 1, characterized in that: The sanitary insecticide composition, when in the form of a dry suspension, comprises the following raw materials in percentage by weight: 1-50% of a piperic acid derivative compound, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 1-10% of a sustained-release agent, 1-10% of a palatant, and the filler is supplemented to 100%.

7. The sanitary insecticidal composition according to claim 1, characterized in that: The sanitary insecticide composition, when in the form of a wettable powder, comprises the following raw materials in percentage by weight: 1-60% of a piperic acid derivative compound, 1-10% of propoxur, 2-6% of a wetting agent, 7-18% of a dispersant, 1-10% of a sustained-release agent, 1-10% of a palatant, and the filler is supplemented to 100%.

8. The sanitary insecticidal composition according to claim 1, characterized in that The sanitary insecticide composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 1-60% of piperic acid derivative compounds, 1-10% of propoxur, 2-15% of wetting agents, 5-20% of dispersants, 2-8% of disintegrants, 1-10% of sustained-release agents, 1-10% of palatants, and the fillers are supplemented to 100%.

9. The sanitary insecticide composition according to any one of claims 2 to 8, characterized in that: The sustained-release agent is any one of methyl cellulose, modified starch, gum arabic, and polyvinyl alcohol, or a mixture of two or more of them in any proportion; the palatant is any one of maltose, sucrose, lactose, and protein sugar, or a mixture of two or more of them in any proportion.

10. Use of the sanitary insecticide composition according to any one of claims 2 to 8 in controlling sanitary pests, characterized in that: When the sanitary insecticide composition is used to control sanitary pests, a residual spraying method is adopted to control sanitary pests: the sanitary insecticide composition is diluted 50-300 times with water and then sprayed on surfaces such as walls, doors, windows, ceilings and homes, so that the sanitary insecticide remains on the surfaces of the above objects, knocking down and killing the sanitary pests; the sanitary pests are Culex pipiens pallens.

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