A vitamin C and dihydroquercetin compound effervescent tablet and its preparation method

Abstract

The present invention discloses a composite effervescent tablet of vitamin C and dihydroquercetin and a preparation method thereof. The composite effervescent tablet of vitamin C and dihydroquercetin comprises the following raw materials in weight: 0.3-2 parts of vitamin C; 0.1-0.7 parts of dihydroquercetin; 25-35 parts of acid source; 20-30 parts of alkali source; 30-70 parts of filler; the acid source is tartaric acid; the alkali source is sodium bicarbonate; the filler is at least one of lactose, β-1,3 / α-1,3-glucan and arabinogalactan. The composite effervescent tablet of vitamin C and dihydroquercetin of the present invention is intended to provide antioxidant, anti-inflammatory and immune support, which helps to maintain overall health and reduce the risk of certain chronic diseases. This form of effervescent tablet is easier to take, making the two ingredients more easily absorbed by the human body, thereby enhancing its efficacy.

Description

Technical Field

[0001] The invention relates to a vitamin C and dihydroquercetin composite effervescent tablet and a preparation method thereof. Background Art

[0002] Vitamin C (ascorbic acid) and dihydroquercetin are two important bioactive compounds that have been extensively studied for their benefits to human health. Found in many foods, such as citrus fruits, strawberries, tomatoes, coconut, pine cones, and wine, these two compounds perform key physiological functions in the body, playing a key role in the immune system, antioxidant defense, and the prevention of a variety of diseases.

[0003] Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that is essential for maintaining human health. It plays an important role in a variety of physiological processes, including:

[0004] Immune System Support: Vitamin C is widely considered a key nutrient for the immune system. It helps enhance the function of white blood cells and improves resistance to viruses and bacteria, thereby helping to prevent colds and other infectious illnesses.

[0005] Antioxidant Defense: Vitamin C is a powerful antioxidant that helps neutralize free radicals and reduce cell damage caused by oxidative stress. This is essential for slowing the aging process and reducing the risk of chronic disease.

[0006] Collagen Synthesis: Vitamin C plays a key role in the formation of collagen, an important protein for maintaining healthy skin, teeth, bones and blood vessels.

[0007] Iron Absorption: Vitamin C helps increase the absorption rate of non-hemoglobin iron, which is essential for preventing anemia and maintaining the health of red blood cells.

[0008] However, because the body cannot synthesize vitamin C on its own, it must be obtained through diet or supplements. Inadequate vitamin C intake may lead to scurvy (a vitamin C deficiency disease), which manifests itself with symptoms such as fatigue, bruising, bleeding gums, and muscle weakness.

[0009] Dihydroquercetin is a natural antioxidant that belongs to the flavonoid class of compounds and is widely distributed in many foods, such as grapes, apples, tea and red wine. It has been widely studied and has shown a variety of health benefits:

[0010] Antioxidant Effect: Dihydroquercetin has a strong ability to fight oxidative stress, helping to neutralize free radicals and reduce cell damage. This is very important for reducing the risk of chronic diseases.

[0011] Anti-inflammatory effects: Dihydroquercetin can reduce inflammation levels in the body and help prevent inflammation-related diseases such as cardiovascular disease and arthritis by inhibiting the release of inflammatory mediators.

[0012] Cardiovascular Health: Studies show that dihydroquercetin may help lower high blood pressure, improve blood vessel health, and reduce the risk of heart disease.

[0013] Diabetic Complications: Dihydroquercetin has been shown to have potential benefits in preventing complications in patients with diabetes, such as arterial disease and retinopathy.

[0014] Liver Health: Dihydroquercetin can protect the liver from damage by toxic substances and viral infections.

[0015] In summary, both vitamin C and dihydroquercetin are compounds with a wide range of biological activities that are important for the immune system, antioxidant defense, and prevention of multiple chronic diseases. Therefore, combining them into a convenient effervescent tablet form has great potential benefits to help people more easily obtain the benefits of these key nutrients. Summary of the invention

[0016] The technical problem to be solved by the present invention is to provide a vitamin C and dihydroquercetin composite effervescent tablet and a preparation method thereof.

[0017] The specific technical scheme of the present invention is:

[0018] The invention discloses a vitamin C and dihydroquercetin composite effervescent tablet, comprising the following raw materials in parts by weight:

[0019] Vitamin C 0.3-2 parts;

[0020] Dihydroquercetin 0.1-0.7 parts;

[0021] 25-35 parts of acid source;

[0022] 20-30 parts of alkali source;

[0023] Filler 30-70 parts.

[0024] The acid source is tartaric acid, the alkali source is sodium bicarbonate, and the acid source and the alkali source together constitute the disintegrant of the effervescent tablet.

[0025] The filler is at least one of lactose, β-1,3 / α-1,3-glucan and arabinogalactan.

[0026] Preferably, a vitamin C and dihydroquercetin composite effervescent tablet comprises the following raw materials in parts by weight:

[0027] Vitamin C 0.5-1.5 parts;

[0028] Dihydroquercetin 0.2-0.5 parts;

[0029] 26-32 parts of acid source;

[0030] 20-25 parts of alkali source;

[0031] 40-60 parts of filler.

[0032] Preferably, a vitamin C and dihydroquercetin composite effervescent tablet comprises the following raw materials in parts by weight:

[0033] Vitamin C 0.7-1.3 parts;

[0034] Dihydroquercetin 0.2-0.4 parts;

[0035] 26-30 parts of acid source;

[0036] 20-24 parts of alkali source;

[0037] 45-55 parts of filler.

[0038] The present invention also discloses a method for preparing the above-mentioned vitamin C and dihydroquercetin composite effervescent tablet, comprising the following steps:

[0039] Mix the acid source and filler evenly.

[0040] Then add vitamin C, dihydroquercetin and alkaline source and mix well.

[0041] Tablet press machine for tableting.

[0042] Preferably, the present invention further discloses a vitamin C and dihydroquercetin composite effervescent tablet, comprising the following raw materials in parts by weight:

[0043] Vitamin C 0.7-1.3 parts;

[0044] Dihydroquercetin 0.2-0.4 parts;

[0045] 26-30 parts of acid source;

[0046] 20-24 parts of alkali source;

[0047] 45-55 parts of filler;

[0048] Stabilizer 0.3-0.6 parts.

[0049] The stabilizer is propylene glycol alginate.

[0050] The present invention also discloses a method for preparing the above-mentioned vitamin C and dihydroquercetin composite effervescent tablet, comprising the following steps:

[0051] Mix the acid source and filler separately and evenly.

[0052] Dihydroquercetin and stabilizer were mixed separately and evenly.

[0053] Mix all the raw materials evenly.

[0054] Tablet press machine for tableting.

[0055] The composite effervescent tablet of vitamin C and dihydroquercetin of the present invention has the following main functions: (1) Vitamin C supplementation: The effervescent tablet provides vitamin C, which is a key nutrient. Vitamin C is essential for the health of the immune system, can enhance the function of the immune system, and help prevent diseases such as colds and flu. In addition, vitamin C also has a positive effect on the health of the skin, teeth and bones, and promotes the formation of collagen. (2) Addition of dihydroquercetin: The dihydroquercetin provided together with vitamin C has powerful antioxidant and anti-inflammatory effects. It helps protect cells from oxidative damage and reduces the level of inflammation in the body. This helps prevent health problems such as cardiovascular disease, diabetic complications, liver damage, etc. (3) Effervescent tablet form: This composite effervescent tablet form makes vitamin C and dihydroquercetin easier to be absorbed and digested by the human body. By dissolving the tablet in water, it can be made into an oral liquid to improve the bioavailability of these two ingredients.

[0056] Overall, the composite effervescent tablet of vitamin C and dihydroquercetin of the present invention is intended to provide antioxidant, anti-inflammatory and immune support, help maintain overall health and reduce the risk of certain chronic diseases. This form of effervescent tablet is easier to take, making the two ingredients more easily absorbed by the human body, thereby enhancing their efficacy. DETAILED DESCRIPTION

[0057] A vitamin C and dihydroquercetin composite effervescent tablet, comprising the following raw materials in parts by weight:

[0058] Vitamin C 0.7-1.3 parts;

[0059] Dihydroquercetin 0.2-0.4 parts;

[0060] 26-30 parts of acid source;

[0061] 20-24 parts of alkali source;

[0062] 45-55 parts of filler.

[0063] The filler is at least one of lactose, β-1,3 / α-1,3-glucan and arabinogalactan. Preferably, the filler is a mixture of lactose, β-1,3 / α-1,3-glucan and arabinogalactan in a mass ratio of (20-40):(5-15):(5-15).

[0064] Vitamin C, also known as ascorbic acid, is one of the main active ingredients in this effervescent tablet. It plays a variety of key roles in the human body, including boosting the immune system, promoting collagen formation, fighting free radicals, and preventing colds and flu. Vitamin C is essential for healthy skin, teeth, and bones. In this formula, the amount of vitamin C ranges from 0.7-1.3 servings, ensuring that each effervescent tablet provides the appropriate dose of vitamin C to meet daily health needs.

[0065] Dihydroquercetin, another key ingredient, is one of the core ingredients of this effervescent tablet. It belongs to a class of bio-based compounds called flavonoids, which have powerful antioxidant and anti-inflammatory properties. Dihydroquercetin helps protect cells from oxidative damage and reduces inflammation levels, which can help prevent cardiovascular disease, diabetic complications, liver damage, and more. In this formula, the amount of dihydroquercetin ranges from 0.2-0.4 parts per serving, ensuring that enough dihydroquercetin is provided to enhance the benefits of the product.

[0066] Tartaric acid plays a key role as an acid source in the preparation of effervescent tablets. They are responsible for the rapid decomposition of effervescent tablets and the generation of bubbles, which allows the tablets to dissolve in water and release the ingredients in them. The content of the acid source ranges from 26-30 parts, ensuring sufficient acidity to maintain the function of the effervescent tablets.

[0067] The role of sodium bicarbonate as an alkali source is to neutralize the acidity generated by the acid source, thereby maintaining the acid-base balance of the effervescent tablet. This helps ensure that the effervescent tablet is safe for consumption in water while maintaining its acid level to promote rapid disintegration. The content of the alkali source ranges from 20-24 parts to ensure sufficient acid-base neutralization reaction.

[0068] The acid source tartaric acid and the alkali source sodium bicarbonate together constitute the disintegrant of the effervescent tablet.

[0069] Lactose is a sugar also known as lactose or milk sugar. It is a disaccharide composed of two simple sugar molecules, glucose and galactose. Lactose is a white crystalline powder that is soluble in water. Lactose is often used as a filler, diluent and auxiliary substance in the pharmaceutical and food industries to adjust the particle size and stability of drugs and nutritional supplements. In addition, lactose is also used in the manufacture of drugs such as sodium lactobionate.

[0070] β-1,3 / α-1,3-glucan is a substance with CAS number: 1439905-58-4. It is made from sucrose through fermentation with Rhizobiumpusense, alcohol precipitation, filtration, separation, drying, and crushing. It is usually a white powder that can form a colloid in water. β-1,3 / α-1,3-glucan can be used as a thickener, stabilizer, and filler in the pharmaceutical and food industries. Its colloid properties make it particularly suitable for the preparation of oral preparations such as capsules and tablets.

[0071] Arabinogalactan is a polysaccharide composed of galactose and glucose molecules connected by α-1,6 bonds. It is usually a colorless or off-white powder that forms a gel-like substance in water. Arabinogalactan is used as a stabilizer, thickener and emulsifier in the food industry. In the pharmaceutical field, it is often used as a filler and auxiliary substance in formulations. Arabinogalactan also has prebiotic benefits and may have a positive impact on intestinal health.

[0072] In the formulation of effervescent tablets, the choice of these fillers depends on the specific needs of the product and the manufacturing process. They not only occupy a portion of the volume in the tablet to make the preparation easier, but also can adjust the concentration of other ingredients to ensure the uniformity and stability of the product. Different fillers can affect the physical properties and performance of effervescent tablets.

[0073] The preparation method of the above-mentioned vitamin C and dihydroquercetin composite effervescent tablet comprises the following steps:

[0074] Mix the acid source and filler evenly.

[0075] Then add vitamin C, dihydroquercetin and alkaline source and mix well.

[0076] Tablet press machine for tableting.

[0077] The present invention uses lactose, β-1,3 / α-1,3-glucan and arabinogalactan as fillers, which have the following dual advantages: on the one hand, they can block the acid source and the alkali source during the mixing process, thereby improving the stability of the disintegrant; on the other hand, lactose, β-1,3 / α-1,3-glucan and arabinogalactan can promote the disintegration process, dissolve quickly after encountering water, and make the acid source and the alkali source contact more fully, thereby accelerating the disintegration and having a shorter disintegration time. It is particularly noteworthy that β-1,3 / α-1,3-glucan and arabinogalactan show more excellent effects in this regard.

[0078] In addition, the present invention also discloses a vitamin C and dihydroquercetin composite effervescent tablet, comprising the following raw materials in parts by weight:

[0079] Vitamin C 0.7-1.3 parts;

[0080] Dihydroquercetin 0.2-0.4 parts;

[0081] 26-30 parts of acid source;

[0082] 20-24 parts of alkali source;

[0083] 45-55 parts of filler;

[0084] Stabilizer 0.3-0.6 parts.

[0085] The stabilizer is propylene glycol alginate.

[0086] The preparation method of the above-mentioned vitamin C and dihydroquercetin composite effervescent tablet comprises the following steps:

[0087] The acid source and filler are mixed separately and evenly;

[0088] Mix dihydroquercetin and stabilizer separately and evenly; By mixing dihydroquercetin and stabilizer separately and evenly first, it can be ensured that these two key ingredients are more evenly dispersed during the mixing process. This helps the stabilizer to fully coat or form a more stable complex with dihydroquercetin, thereby improving the protective effect of the stabilizer on dihydroquercetin.

[0089] Then mix all the raw materials evenly;

[0090] Tablet press machine for tableting.

[0091] The role of propylene glycol alginate in this formula is to improve the stability and bioavailability of dihydroquercetin. It helps to form a stable complex with dihydroquercetin, thereby protecting the latter's activity and ensuring that the product will not fail in the acidic environment of water. In addition, propylene glycol alginate may interact with dihydroquercetin to promote the latter's faster dissolution and release in water. This may be due to the molecular structure and properties of propylene glycol alginate better fitting with dihydroquercetin, thereby improving the latter's solubility and release rate in water. Therefore, propylene glycol alginate plays a key role in the present invention, not only improving the stability of dihydroquercetin, but also enhancing the bioavailability of dihydroquercetin in the product. The problem of poor solubility of dihydroquercetin in water in effervescent tablets is solved, and the dissolution of active ingredients during administration is increased to promote human absorption.

[0092] The present invention adopts a powder direct tableting method, skips the cumbersome steps of granulation, and directly performs tableting. This preparation method brings multiple advantages. First, it saves a lot of time and energy, improves production efficiency, and reduces costs. Secondly, the process is more simplified, reduces the complexity of the preparation process, and is conducive to batch production. In addition, this method can also avoid contact with water, effectively improve the stability of the effervescent tablet, extend its shelf life, and ensure that the quality and efficacy of the product are not affected.

[0093] In a specific embodiment of the present invention, the relevant raw materials are introduced as follows:

[0094] Vitamin C, product number wss13 Vitamin C provided by Zhengzhou Sanhe Food Additive Co., Ltd.

[0095] Dihydroquercetin, food grade dihydroquercetin provided by Nanjing Tongying Biotechnology Co., Ltd., with a content of 98%.

[0096] Tartaric acid, food grade DL-tartaric acid provided by Shandong Huiheng Biotechnology Co., Ltd., content 99%.

[0097] Sodium bicarbonate, food grade Haihua brand sodium bicarbonate provided by Jinan Kunfeng Chemical Co., Ltd., content 99%.

[0098] Lactose, CAS number: 63-42-3, food grade D-lactose provided by Shandong Yatu Biotechnology Co., Ltd.

[0099] β-1,3 / α-1,3-glucan is a linear polysaccharide composed of 9 D-glucose repeating units formed by 7 β-1,3-D-glucose and 2 α-1,3-glucose connected to each other. The content of β-1,3 / α-1,3-glucan in this product is 95g / 100g.

[0100] Arabinogalactan, food grade Arabinogalactan provided by Shandong Gushuo Biotechnology Co., Ltd., has a content of 99%.

[0101] Propylene glycol alginate, food grade propylene glycol alginate provided by Jiangxi Baiying Biotechnology Co., Ltd.

[0102] Glucose, food grade glucose provided by Guangdong Baian Chemical Co., Ltd., with an active ingredient content of 99.5%.

[0103] Xanthan gum, food grade xanthan gum provided by Henan Rongshen Chemical Co., Ltd., content 99%.

[0104] Sodium hyaluronate, food grade sodium hyaluronate provided by Hebei Jiuyu Biotechnology Co., Ltd., content 99%.

[0105] Polyethylene glycol 6000, high-quality polyethylene glycol 6000 provided by Yunsheng Chemical (Shandong) Co., Ltd., has a content of 99.8%.

[0106] Sodium alginate, food grade sodium alginate provided by Shaanxi Yunsheng Biotechnology Co., Ltd., content 99%.

[0107] Embodiment 1:

[0108] A vitamin C and dihydroquercetin composite effervescent tablet, comprising the following raw materials in parts by weight:

[0109] Vitamin C 1.0 part;

[0110] Dihydroquercetin 0.3 parts;

[0111] Acid source: tartaric acid 28 parts;

[0112] Alkali source sodium bicarbonate 22 parts;

[0113] Filler lactose 50 parts.

[0114] The preparation method of vitamin C and dihydroquercetin composite effervescent tablet comprises the following steps:

[0115] (1) Mix the acid source and filler evenly under dry conditions.

[0116] (2) While maintaining dry conditions, add vitamin C, dihydroquercetin and an alkali source and mix well.

[0117] (3) The tablets were pressed using a tablet press with a pressure of 30 kN and a mass of 4 g per tablet.

[0118] Embodiment 2:

[0119] A vitamin C and dihydroquercetin composite effervescent tablet, comprising the following raw materials in parts by weight:

[0120] Vitamin C 1.0 part;

[0121] Dihydroquercetin 0.3 parts;

[0122] Acid source: tartaric acid 28 parts;

[0123] Alkali source sodium bicarbonate 22 parts;

[0124] Filler lactose 30 parts;

[0125] Filler: 20 parts of arabinogalactan.

[0126] The preparation method of vitamin C and dihydroquercetin composite effervescent tablet comprises the following steps:

[0127] (1) Mix the acid source and filler evenly under dry conditions.

[0128] (2) While maintaining dry conditions, add vitamin C, dihydroquercetin and an alkali source and mix well.

[0129] (3) The tablets were pressed using a tablet press with a pressure of 30 kN and a mass of 4 g per tablet.

[0130] Embodiment 3:

[0131] A vitamin C and dihydroquercetin composite effervescent tablet, comprising the following raw materials in parts by weight:

[0132] Vitamin C 1.0 part;

[0133] Dihydroquercetin 0.3 parts;

[0134] Acid source: tartaric acid 28 parts;

[0135] Alkali source sodium bicarbonate 22 parts;

[0136] Filler lactose 30 parts;

[0137] Filler β-1,3 / α-1,3-glucan 20 parts.

[0138] The preparation method of vitamin C and dihydroquercetin composite effervescent tablet comprises the following steps:

[0139] (1) Mix the acid source and filler evenly under dry conditions.

[0140] (2) While maintaining dry conditions, add vitamin C, dihydroquercetin and an alkali source and mix well.

[0141] (3) The tablets were pressed using a tablet press with a pressure of 30 kN and a mass of 4 g per tablet.

[0142] Embodiment 4:

[0143] A vitamin C and dihydroquercetin composite effervescent tablet, comprising the following raw materials in parts by weight:

[0144] Vitamin C 1.0 part;

[0145] Dihydroquercetin 0.3 parts;

[0146] Acid source: tartaric acid 28 parts;

[0147] Alkali source sodium bicarbonate 22 parts;

[0148] Filler lactose 30 parts;

[0149] Filler β-1,3 / α-1,3-glucan 10 parts;

[0150] Filler: 10 parts of arabinogalactan.

[0151] The preparation method of vitamin C and dihydroquercetin composite effervescent tablet comprises the following steps:

[0152] (1) Mix the acid source and filler evenly under dry conditions.

[0153] (2) While maintaining dry conditions, add vitamin C, dihydroquercetin and an alkali source and mix well.

[0154] (3) The tablets were pressed using a tablet press with a pressure of 30 kN and a mass of 4 g per tablet.

[0155] Embodiment 5:

[0156] A vitamin C and dihydroquercetin composite effervescent tablet, comprising the following raw materials in parts by weight:

[0157] Vitamin C 1.0 part;

[0158] Dihydroquercetin 0.3 parts;

[0159] Acid source: tartaric acid 28 parts;

[0160] Alkali source sodium bicarbonate 22 parts;

[0161] Filler lactose 30 parts;

[0162] Filler β-1,3 / α-1,3-glucan 10 parts;

[0163] Filler arabinogalactan 10 parts;

[0164] Stabilizer propylene glycol alginate 0.5 parts.

[0165] The preparation method of vitamin C and dihydroquercetin composite effervescent tablet comprises the following steps:

[0166] (1) Under dry conditions, the acid source and the filler are mixed uniformly to obtain powder A.

[0167] (2) While maintaining dry conditions, the stabilizer and dihydroquercetin are mixed to obtain powder B.

[0168] (3) While maintaining dry conditions, add powder A, powder B, vitamin C and alkali source and mix well.

[0169] (4) The tablets were pressed using a tablet press with a pressure of 30 kN and a mass of 4 g per tablet.

[0170] Comparative Example 1:

[0171] The only difference from Example 1 is that the filler lactose is replaced by an equal amount of glucose.

[0172] Comparative Example 2:

[0173] The only difference from Example 5 is that the stabilizer propylene glycol alginate is replaced by an equal amount of xanthan gum.

[0174] Comparative Example 3:

[0175] The only difference from Example 5 is that the stabilizer propylene glycol alginate is replaced by an equal amount of sodium hyaluronate.

[0176] Comparative Example 4:

[0177] The only difference from Example 5 is that the stabilizer propylene glycol alginate is replaced by an equal amount of polyethylene glycol 6000.

[0178] Comparative Example 5:

[0179] The only difference from Example 5 is that the stabilizer propylene glycol alginate is replaced by an equal amount of sodium alginate.

[0180] Comparative Example 6:

[0181] The formula is the same as that of Example 5, except that the preparation method is different. The specific preparation method is as follows:

[0182] The preparation method of vitamin C and dihydroquercetin composite effervescent tablet comprises the following steps:

[0183] (1) Under dry conditions, the acid source and the filler are mixed uniformly to obtain powder A.

[0184] (2) While maintaining dry conditions, mix powder A, stabilizer, vitamin C, dihydroquercetin and alkaline source evenly.

[0185] (3) The tablets were pressed using a tablet press with a pressure of 30 kN and a mass of 4 g per tablet.

[0186] Test Example 1:

[0187] Disintegration time test:

[0188] Ten composite effervescent tablets prepared in the examples and comparative examples were placed in 50 mL of distilled water at 25° C. The time taken for the tablets to dissolve or disperse in the water without any aggregated particles remaining when the gas around the tablets or fragments stopped escaping was averaged.

[0189] Table 1 Test results of disintegration performance of composite effervescent tablets

[0190] Disintegration time, seconds Example 1 204 Example 2 186 Example 3 172 Example 4 150 Example 5 153 Comparative Example 1 231 Comparative Example 2 151 Comparative Example 3 155 Comparative Example 4 152 Comparative Example 5 153 Comparative Example 6 156

[0191] Example 1 (lactose filler): disintegration time was 204 seconds. Example 2 (lactose and arabinogalactan filler): disintegration time was 186 seconds. Example 3 (lactose and β-1,3 / α-1,3-glucan filler): disintegration time was 172 seconds. Example 4 (lactose, β-1,3 / α-1,3-glucan and arabinogalactan filler): disintegration time was 150 seconds. Comparative Example 1 (glucose filler): disintegration time was 231 seconds.

[0192] Filler type and combination: In these examples, the filler type and combination are different. Example 1 uses lactose alone as a filler, while Example 2 uses a combination of lactose and arabinogalactan, Example 3 uses a combination of lactose and β-1,3 / α-1,3-glucan, and Example 4 uses a combination of lactose, β-1,3 / α-1,3-glucan, and arabinogalactan. Comparative Example 1 uses glucose as a filler.

[0193] Disintegration time: The disintegration time is the time required for the effervescent tablet to completely disintegrate and release its active ingredient. In these examples, the disintegration time gradually decreases from Example 1 to Example 4, the shortest disintegration time occurs in Example 4, and the disintegration time of Comparative Example 1 is the longest.

[0194] Effect of fillers: Fillers play a key role in the preparation of these effervescent tablets. Different types and combinations of fillers have different dissolution characteristics and stability. Lactose dissolves slowly during disintegration, so the disintegration time of Example 1 is longer. In Examples 2 and 3, the combination of arabinogalactan and β-1,3 / α-1,3-glucan increased the disintegration rate and shortened the disintegration time. In Example 4, the combination of the three fillers produced the shortest disintegration time, indicating that they have a synergistic effect in the disintegration process, allowing the acid source and the base source to contact faster, thereby promoting disintegration.

[0195] Results of Comparative Example 1: Comparative Example 1 used glucose as a filler, and its disintegration time was the longest, indicating that glucose was not as effective as other fillers in the preparation of this effervescent tablet. This emphasizes that the choice of filler has an important impact on the performance of the effervescent tablet.

[0196] In conclusion, the type and combination of fillers have a significant effect on the disintegration time of effervescent tablets, and different fillers may affect the stability and disintegration performance of effervescent tablets.

[0197] Test Example 2:

[0198] Dissolution transfer rate of dihydroquercetin composite effervescent tablets

[0199] (1) Preparation of dihydroquercetin reference solution

[0200] Weigh 14 mg of dihydroquercetin, dilute to 100 mL with methanol, filter through a 0.22 μm filter membrane, and take the filtrate for liquid phase detection;

[0201] (2) Preparation of dihydroquercetin aqueous solution sample

[0202] Add 21 mg of dihydroquercetin to 1000 mL of water and mix well, filter through a 0.22 μm filter membrane, and take the filtrate for liquid phase detection;

[0203] (3) Add one composite effervescent tablet to 50 mL of water and mix evenly, filter through a 0.22 μm filter membrane, and take the filtrate for liquid phase detection;

[0204] (4) Liquid phase conditions: chromatographic column: Dikma Technologies Diamonsil C18 (5 μm, 250 mm×4.6 mm); mobile phase: V (methanol)-(water)=40:60 (1% H 3 PO 4 ); volume flow rate: 1.0 mL / min; detection wavelength: 289 nm; column temperature: 25 °C, injection volume: 10 μL.

[0205] (5) Calculation of dihydroquercetin dissolution transfer rate

[0206] Dissolution transfer rate = dihydroquercetin content after dissolution / theoretical value of dihydroquercetin content*100%.

[0207] Table 2 Dissolution transfer rate test results

[0208] Dissolution transfer rate, % Example 1 79.6 Example 2 81.0 Example 3 82.7 Example 4 84.5 Example 5 92.8 Comparative Example 1 77.9 Comparative Example 2 86.1 Comparative Example 3 87.4 Comparative Example 4 85.5 Comparative Example 5 85.2 Comparative Example 6 89.0

[0209] The stabilizer used in Example 5 is propylene glycol alginate, which may have a significant effect on the dissolution transfer rate of dihydroquercetin. Propylene glycol alginate may play an important role in the effervescent tablet, helping to improve the stability and solubility of dihydroquercetin.

[0210] The experiment also shows that different stabilizers may have different effects on improving the dissolution transfer rate. Compared with other comparative examples 2-5 (xanthan gum, sodium hyaluronate, polyethylene glycol 6000, sodium alginate), Example 5 (propylene glycol alginate) has a more significant effect.

[0211] Propylene glycol alginate may have excellent solubility and stability properties, making it an ideal choice to improve the solubility transfer rate of dihydroquercetin. This stabilizer may better promote the dispersion and solubility of dihydroquercetin, thereby improving its bioavailability.

Claims

1. A vitamin C and dihydroquercetin composite effervescent tablet, characterized in that: In parts by weight, the raw materials are composed of: Vitamin C 0.3-2 parts; Dihydroquercetin 0.1-0.7 parts; 25-35 parts of acid source; 20-30 parts of alkali source; 30-70 parts of filler; The filler is a mixture of lactose, β-1,3 / α-1,3-glucan and arabinogalactan in a mass ratio of (20-40):(5-15):(5-15); The acid source is tartaric acid; The alkali source is sodium bicarbonate; The vitamin C and dihydroquercetin composite effervescent tablet is prepared by the following steps: Mix the acid source and filler evenly. Then add vitamin C, dihydroquercetin and alkaline source and mix well. Tablet press machine for tableting.

2. The vitamin C and dihydroquercetin composite effervescent tablet according to claim 1, characterized in that: In parts by weight, the raw materials are composed of: Vitamin C 0.5-1.5 parts; Dihydroquercetin 0.2-0.5 parts; 26-32 parts of acid source; 20-25 parts of alkali source; 40-60 parts of filler.

3. The vitamin C and dihydroquercetin composite effervescent tablet according to claim 2, characterized in that: In parts by weight, the raw materials are composed of: Vitamin C 0.7-1.3 parts; Dihydroquercetin 0.2-0.4 parts; 26-30 parts of acid source; 20-24 parts of alkali source; 45-55 parts of filler.

4. A vitamin C and dihydroquercetin composite effervescent tablet, characterized in that: In parts by weight, the raw materials are composed of: Vitamin C 0.7-1.3 parts; Dihydroquercetin 0.2-0.4 parts; 26-30 parts of acid source; 20-24 parts of alkali source; 45-55 parts of filler; Stabilizer 0.3-0.6 parts; The stabilizer is propylene glycol alginate; The acid source is tartaric acid; The alkali source is sodium bicarbonate; The vitamin C and dihydroquercetin composite effervescent tablet is prepared by the following steps: Mix the acid source and filler separately and evenly. Dihydroquercetin and stabilizer were mixed separately and evenly. Mix all the raw materials evenly. Tablet press machine for tableting.

5. The method for preparing the vitamin C and dihydroquercetin composite effervescent tablet according to any one of claims 1 to 3, characterized in that: The steps include: Mix the acid source and filler evenly. Then add vitamin C, dihydroquercetin and alkaline source and mix well. Tablet press machine for tableting.

6. The method for preparing the vitamin C and dihydroquercetin composite effervescent tablet according to claim 4, characterized in that: The steps include: Mix the acid source and filler separately and evenly. Dihydroquercetin and stabilizer were mixed separately and evenly. Mix all the raw materials evenly. Tablet press machine for tableting.