A water-soluble human lubricant suitable for multiple occasions and a preparation method thereof

Abstract

The invention discloses a water-soluble human body lubricant applicable to multiple occasions and a preparation method thereof. The lubricant comprises the following raw materials, by weight: 70-84 parts of water, 15-25 parts of moisturizing agent, 0.5-1.5 parts of thickener, 0.5-1 parts of neutralizer, 0.1-0.9 parts of stabilizer and 0.02-0.1 parts of preservative. The lubricant is skin-friendly and non-irritating, easy to clean, applicable to multiple occasions, and has a long-lasting moisturizing and lubricating effect, and does not require frequent re-application.

Description

Technical Field

[0001] The invention belongs to the technical field of medical or hygienic materials, and in particular relates to a water-soluble human body lubricant suitable for multiple occasions and a preparation method thereof. Background Art

[0002] For the human body, water-soluble lubricant is a lubricating product with the most natural feel. Its main ingredient is water, and it usually also contains glycerin, polyols, sodium hyaluronate and preservatives. It can be used for lubrication of medical devices entering human cavities, lubrication during sexual intercourse and lubrication of condoms.

[0003] Patent CN103785068B discloses a water-soluble lubricant and a preparation method thereof, which is composed of the following raw materials: glycerin, sorbitol, phenoxyethanol, carbomer, sodium hydroxide, potassium sorbate, propylparaben and pure water. The lubricant has strong applicability, good lubrication effect, and no residue. It can reduce the friction or damage to the human mucosa caused by the operation of instruments in the natural cavity of the human body. However, some water-soluble components are easily evaporated by air and absorbed by the skin, resulting in dryness and loss of lubrication effect. It may be necessary to reapply in the middle to maintain a good lubrication effect.

[0004] Patent CN105999426B discloses a hyaluronic acid water-soluble human lubricant containing the following components: hydroxyethyl cellulose, sodium hyaluronate, rose extract, polylysine, glycerin and purified water. The lubricant contains rose extract, which is more environmentally friendly and safer. However, it still poses potential risks to some people who are prone to allergies. Summary of the invention

[0005] In order to overcome the deficiencies of the above-mentioned prior art, the present invention provides a water-soluble human lubricant suitable for multiple occasions and a preparation method thereof. The lubricant is skin-friendly, non-irritating, easy to clean, has a long-lasting moisturizing and lubricating effect, and does not require frequent reapplication.

[0006] In order to achieve the above object, the technical solution adopted by the present invention is:

[0007] The first aspect of the present invention provides a water-soluble human lubricant suitable for multiple occasions, comprising the following raw materials by weight: 70-84 parts of water, 15-25 parts of moisturizing agent, 0.5-1.5 parts of thickener, 0.5-1 parts of neutralizer, 0.1-0.9 parts of stabilizer and 0.02-0.1 parts of preservative;

[0008] Wherein, the moisturizing agent comprises modified sodium hyaluronate and glycerin;

[0009] The stabilizer comprises sodium polyacrylate and EDTA-2Na.

[0010] In some embodiments, the preparation steps of the modified sodium hyaluronate are as follows:

[0011] S1. Dissolve sodium hyaluronate in deionized water, add 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and adipic acid dihydrazide, adjust the pH to 4-5, stir at room temperature for 1.5-2.5 hours, and after the reaction is completed, adjust the pH to neutral, dialyze with deionized water for 44-52 hours to obtain pretreated sodium hyaluronate;

[0012] S2, dissolving monoterpene alcohol, succinic anhydride and 4-dimethylaminopyridine in a solvent, adding pyridine under the protection of an inert gas, stirring at room temperature for 20-28 hours, washing and drying after the reaction is completed to obtain a reactant;

[0013] S3. Dissolve the reactant in step S2 in N,N-dimethylformamide, add 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, stir for 1-3 hours, then add the pretreated sodium hyaluronate in step S1, stir at room temperature for 20-28 hours, then add sulfur trioxide pyridine and stir at room temperature for 15-25 minutes, dialyze with deionized water for 40-60 hours to obtain the modified sodium hyaluronate.

[0014] In some embodiments, the relative molecular mass of sodium hyaluronate in step S1 is 8000-10000.

[0015] Sodium hyaluronate can combine with a large amount of water to produce strong hydrophilicity, so it has strong moisturizing properties. It is currently the substance with the best moisturizing properties in nature. As a moisturizer, it has good safety, high purity, excellent lubricity and film-forming properties. The applicant avoids the sticky skin feel and makes it easy to wash by selecting the relative molecular weight of sodium hyaluronate, but it also brings the characteristics of fast drying speed, strong fluidity and difficulty in staying on the skin surface to the water-based lubricant.

[0016] In some embodiments, the mass ratio of sodium hyaluronate to adipic acid dihydrazide in step S1 is 1:(1.3-1.42).

[0017] In some embodiments, the moisturizing agent further comprises propylene glycol, butylene glycol, 1,2-hexanediol and fucoidan sulfate.

[0018] Preferably, the moisturizing agent further comprises, by weight, 4-7 parts of propylene glycol, 2.5-3.5 parts of butylene glycol, 2.5-3.5 parts of 1,2-hexanediol and 0.5-1.8 parts of fucoidan sulfate.

[0019] In some embodiments, the monoterpene alcohol is geraniol.

[0020] The applicant introduced monoterpene alcohol extracted from natural plants into sodium hyaluronate, which brought significant antibacterial, antiviral and antifungal properties to the lubricant without attacking the normal skin flora. However, the introduction of monoterpene alcohol will affect the water solubility of sodium hyaluronate. For this reason, the water solubility is compensated by introducing sulfonic acid groups. In addition, the introduction of long chains of monoterpene alcohol will cause some physical entanglement in the modified sodium hyaluronate, which is similar to increasing the degree of cross-linking and enhancing the retention and water retention, reducing the amount used at one time and the number of re-applications.

[0021] The applicant has compounded a variety of moisturizing agents to provide the lubricant with characteristics such as not drying out easily, having a good skin feel, and being easy to clean. Among them, fucoidan sulfate has a moisturizing and hygroscopic activity similar to that of sodium hyaluronate. The two can work together to automatically adjust in different environments, preventing glycerin from absorbing moisture from the skin when the air is dry.

[0022] In some embodiments, the preservative comprises caprylhydroxamic acid, capryloylglycine.

[0023] Preferably, the mass ratio of octanoylhydroxamic acid to octanoylglycine is 1:(0.6-1).

[0024] In some embodiments, the neutralizing agent comprises triethanolamine.

[0025] The applicant selected a low-irritation preservative and used triethanolamine to adjust the pH value of the product to maintain it between 3-7, so that caprylhydroxamic acid can exert its antibacterial effect. However, the antibacterial spectrum of caprylhydroxamic acid is relatively single, and the antibacterial effect is weak when used alone. The present application uses it together with propylene glycol and hexylene glycol in moisturizing agents and capryloylglycine to achieve a combined antibacterial and synergistic effect.

[0026] Although capryloyl glycine has a strong inhibitory effect on Staphylococcus aureus and Propionibacterium acnes, it is almost insoluble in water. The applicant found that adding fucoidan sulfate can improve its solubility and reduce the process time cost. The possible reason is that the lipid structure of fucoidan sulfate promotes dissolution.

[0027] In some embodiments, the thickening agent comprises carbomer.

[0028] The present application also neutralizes carbomer by triethanolamine to form a stable polymer structure, thereby achieving the effects of thickening and moisturizing.

[0029] The second aspect of the present invention provides a method for preparing a water-soluble human lubricant suitable for multiple occasions, comprising the following steps:

[0030] A1. Soften water to obtain softened water;

[0031] A2, stirring the glycerin in the moisturizing agent and the sodium polyacrylate in the stabilizer for 30-70 minutes, degassing, and filtering to obtain component 1;

[0032] A3. Homogenize the softened water, thickener and the remaining moisturizing agent and stabilizer for 5-10 minutes, stir at 70-90° C. for 20-60 minutes and then degas, add component 1 obtained in step A2, keep warm for 20-40 minutes, cool to below 40° C., add a neutralizer and a preservative, and stir evenly to obtain the water-soluble human lubricant suitable for multiple occasions.

[0033] The applicant first mixed sodium polyacrylate with glycerol and dissolved it in the glycerol to form a matrix. This mixture may bring good wettability and low interfacial tension, making it easier to mix and dissolve with other substances later.

[0034] In some embodiments, the conductivity of the softened water in step A1 is ≤5 μs / cm.

[0035] Compared with the prior art, the present invention has the following beneficial effects:

[0036] 1. The present invention provides a water-soluble lubricant for human body which is skin-friendly, non-irritating and easy to clean, suitable for various occasions, and has a long-lasting moisturizing and lubricating effect, and does not require frequent reapplication.

[0037] 2. The present invention modifies sodium hyaluronate to impart antibacterial, antiviral and antifungal properties to the lubricant without attacking the normal flora of the skin, thereby reducing the amount of preservatives used, and compensating for the problem of decreased water solubility of sodium hyaluronate caused by monoterpene alcohol by introducing sulfonic acid groups.

[0038] 3. The modified sodium hyaluronate of the present invention enhances the retention and water retention of the lubricant, reducing the amount used at one time and the number of re-applications.

[0039] 4. The low-irritation preservatives in the present invention can achieve a compound antibacterial and synergistic effect with triethanolamine, propylene glycol and hexylene glycol, wherein the fucoidan sulfate can also increase the solubility of capryloyl glycine in water and reduce the time cost of the lubricant process. DETAILED DESCRIPTION

[0040] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following embodiments are examples of the present invention and are only used to illustrate the present invention, but not to limit the present invention. Other combinations and various modifications within the concept of the present invention may be performed without departing from the spirit or scope of the present invention.

[0041] In order to facilitate those skilled in the art to implement the present invention, some raw materials and manufacturers of the embodiments and comparative examples are described as follows:

[0042] Sodium hyaluronate was purchased from Bloomage Biotech Co., Ltd. with a relative molecular mass of 8000;

[0043] Sodium polyacrylate was purchased from Hubei Zhonglong Kangsheng Fine Chemical Co., Ltd.;

[0044] Fucoidan sulfate was purchased from Shaanxi Haoyang Biotechnology Co., Ltd.

[0045] Preparation Example 1

[0046] The preparation steps of modified sodium hyaluronate-A are as follows:

[0047] S1. Dissolve 60 g of sodium hyaluronate in 1 L of deionized water, add 36.4 g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and 82.7 g of adipic acid dihydrazide, adjust the pH to 4.8, stir at room temperature for 2 h, and after the reaction is completed, adjust the pH to neutral with 1 mol / L sodium hydroxide solution, and dialyze with deionized water for 48 h using a dialysis bag with a cutoff relative molecular mass of 8000 to obtain pretreated sodium hyaluronate;

[0048] S2, dissolving 15.4 g of monoterpene alcohol, 12 g of succinic anhydride and 0.1 g of 4-dimethylaminopyridine in 500 mL of dichloromethane, adding 7.9 g of pyridine under nitrogen protection, stirring at room temperature for 24 h, and after the reaction, washing with 2 mol / L HCl and water, and drying with anhydrous sodium sulfate to obtain a reactant;

[0049] S3. Dissolve 25.5 g of the reactant in step S2 in 200 mL of N,N-dimethylformamide, add 38.3 g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, stir for 2 h, then add 51.9 g of the pretreated sodium hyaluronate in step S1, stir at room temperature for 24 h, then add 31.3 g of sulfur trioxide pyridine and stir at room temperature for 20 min, dialyze with deionized water in a dialysis bag with a cutoff relative molecular mass of 3500 for 48 h to obtain the modified sodium hyaluronate-A.

[0050] Preparation Example 2

[0051] The preparation steps of modified sodium hyaluronate-B are as follows:

[0052] The difference between this preparation example and preparation example 1 is that the amount of adipic acid dihydrazide used in step S1 is 66 g.

[0053] Preparation Example 3

[0054] The preparation steps of modified sodium hyaluronate-C are as follows:

[0055] The difference between this preparation example and preparation example 1 is that the amount of adipic acid dihydrazide used in step S1 is 87 g.

[0056] Preparation Example 4

[0057] The preparation steps of modified sodium hyaluronate-D are as follows:

[0058] S1. Dissolve 60 g of sodium hyaluronate in 1 L of deionized water, add 36.4 g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and 82.7 g of adipic acid dihydrazide, adjust the pH to 4.8, stir at room temperature for 2 h, and after the reaction is completed, adjust the pH to neutral with 1 mol / L sodium hydroxide solution, and dialyze with deionized water for 48 h using a dialysis bag with a cutoff relative molecular mass of 8000 to obtain pretreated sodium hyaluronate;

[0059] S2, dissolving 15.4 g of monoterpene alcohol, 12 g of succinic anhydride and 0.1 g of 4-dimethylaminopyridine in 500 mL of dichloromethane, adding 7.9 g of pyridine under nitrogen protection, stirring at room temperature for 24 h, and after the reaction, washing with 2 mol / L HCl and water, and drying with anhydrous sodium sulfate to obtain a reactant;

[0060] S3. Dissolve 25.5 g of the reactant in step S2 in 200 mL of N,N-dimethylformamide, add 38.3 g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, stir for 2 h, then add 51.9 g of the pretreated sodium hyaluronate in step S1, stir at room temperature for 24 h, and dialyze with deionized water in a dialysis bag with a cutoff relative molecular mass of 3500 for 48 h to obtain the modified sodium hyaluronate-D.

[0061] Example 1

[0062] A water-soluble human lubricant suitable for multiple occasions, comprising the following raw materials by weight: 78 parts of water, 20 parts of moisturizing agent, 1 part of carbomer, 0.8 parts of triethanolamine, 0.6 parts of stabilizer and 0.06 parts of preservative;

[0063] The moisturizing agent contains 1.5 parts of modified sodium hyaluronate-A, 7 parts of glycerin, 5 parts of propylene glycol, 3 parts of butylene glycol, 3 parts of 1,2-hexanediol and 0.5 parts of fucoidan sulfate;

[0064] The stabilizer includes 0.35 parts of sodium polyacrylate and 0.25 parts of EDTA-2Na;

[0065] The preservatives comprised 0.03 parts of capryloylhydroxamic acid and 0.03 parts of capryloylglycine.

[0066] The preparation method of the water-soluble human body lubricant applicable to multiple occasions in this embodiment comprises the following steps:

[0067] A1. The water is filtered through a water softener to obtain softened water with a conductivity of ≤5μs / cm;

[0068] A2, stirring glycerin and sodium polyacrylate in the moisturizing agent for 50 minutes, degassing, and filtering to obtain component 1;

[0069] A3. Homogenize softened water, carbomer, modified sodium hyaluronate-A, propylene glycol, butylene glycol, 1,2-hexanediol, fucoidan sulfate and EDTA-2Na for 7 minutes, stir at 80°C for 40 minutes and then degas, add component 1 obtained in step A2, keep warm for 30 minutes, cool to below 40°C, add triethanolamine and preservatives, and stir evenly to obtain the water-soluble human lubricant suitable for multiple occasions.

[0070] Example 2

[0071] A water-soluble human lubricant suitable for multiple occasions, comprising the following raw materials by weight: 72 parts of water, 18 parts of moisturizing agent, 0.7 parts of carbomer, 0.5 parts of triethanolamine, 0.3 parts of stabilizer and 0.04 parts of preservative;

[0072] The moisturizing agent contains 1.2 parts of modified sodium hyaluronate-A, 6 parts of glycerin, 4 parts of propylene glycol, 2.5 parts of butylene glycol, 2.5 parts of 1,2-hexanediol and 1.8 parts of fucoidan sulfate;

[0073] The stabilizer includes 0.2 parts of sodium polyacrylate and 0.1 parts of EDTA-2Na;

[0074] The preservatives comprised 0.02 parts of capryloylhydroxamic acid and 0.02 parts of capryloylglycine.

[0075] The preparation method of the water-soluble human body lubricant applicable to multiple occasions in this embodiment comprises the following steps:

[0076] A1. The water is filtered through a water softener to obtain softened water with a conductivity of ≤5μs / cm;

[0077] A2, stirring the glycerin in the moisturizing agent and the sodium polyacrylate in the stabilizer for 40 minutes, degassing, and filtering to obtain component 1;

[0078] A3. Homogenize softened water, carbomer, modified sodium hyaluronate-A, propylene glycol, butylene glycol, 1,2-hexanediol, fucoidan sulfate and EDTA-2Na for 5 minutes, stir at 70°C for 60 minutes and then degas, add component 1 obtained in step A2, keep warm for 20 minutes, cool to below 40°C, add triethanolamine and preservatives, and stir evenly to obtain the water-soluble human lubricant suitable for multiple occasions.

[0079] Example 3

[0080] A water-soluble human lubricant suitable for multiple occasions, comprising the following raw materials by weight: 84 parts of water, 25 parts of moisturizing agent, 1.5 parts of carbomer, 1 part of triethanolamine, 0.9 parts of stabilizer and 0.1 parts of preservative;

[0081] The moisturizing agent contains 2 parts of modified sodium hyaluronate-A, 8 parts of glycerin, 7 parts of propylene glycol, 3.5 parts of butylene glycol, 3.5 parts of 1,2-hexanediol and 1 part of fucoidan sulfate;

[0082] The stabilizer includes 0.5 parts of sodium polyacrylate and 0.4 parts of EDTA-2Na;

[0083] The preservatives comprised 0.06 parts of capryloylhydroxamic acid and 0.04 parts of capryloylglycine.

[0084] The preparation method of the water-soluble human body lubricant applicable to multiple occasions in this embodiment comprises the following steps:

[0085] A1. The water is filtered through a water softener to obtain softened water with a conductivity of ≤5μs / cm;

[0086] A2, stirring the glycerin in the moisturizing agent and the sodium polyacrylate in the stabilizer for 70 minutes, degassing, and filtering to obtain component 1;

[0087] A3. Homogenize softened water, carbomer, modified sodium hyaluronate-A, propylene glycol, butylene glycol, 1,2-hexanediol, fucoidan sulfate and EDTA-2Na for 10 minutes, stir at 90°C for 20 minutes and then degas, add component 1 obtained in step A2, keep warm for 40 minutes, cool to below 40°C, add triethanolamine and preservatives, and stir evenly to obtain the water-soluble human lubricant suitable for multiple occasions.

[0088] Example 4

[0089] This embodiment provides a water-soluble human body lubricant suitable for multiple occasions and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the moisturizing agent does not contain fucoidan sulfate.

[0090] Example 5

[0091] This embodiment provides a water-soluble human lubricant suitable for multiple occasions and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the modified sodium hyaluronate-A in the raw material is replaced by an equal portion of modified sodium hyaluronate-B.

[0092] Example 6

[0093] This embodiment provides a water-soluble human lubricant suitable for multiple occasions and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the modified sodium hyaluronate-A in the raw material is replaced by an equal portion of modified sodium hyaluronate-C.

[0094] Example 7

[0095] This embodiment provides a water-soluble human lubricant suitable for multiple occasions and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the modified sodium hyaluronate-A in the raw material is replaced by an equal portion of modified sodium hyaluronate-D.

[0096] Comparative Example 1

[0097] This comparative example provides a water-soluble human lubricant suitable for multiple occasions and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the modified sodium hyaluronate-A in the raw material is replaced by an equal portion of sodium hyaluronate.

[0098] Performance Test:

[0099] 1. Moisturizing experiment:

[0100] Take 0.2g (accurate to 0.0001g) of the lubricant in each embodiment and apply it on a 7.5cm×7.5cm glass plate with 3M tape, put it in a dryer filled with a saturated potassium acetate solution, the relative humidity in the dryer is 62%, weigh it after standing for 4 hours, and calculate the moisture retention rate. The moisture retention rate calculation formula is: Moisture retention rate %=m2 / m1×100%, where: m1 is the water content of the sample before placement, and m2 is the water content of the sample after placement.

[0101] 2. Antibacterial Experiment

[0102] This experiment was carried out in accordance with the quantitative antibacterial test of suspension in the standard WS / T 650-2019 "Antibacterial and Antibacterial Effect Evaluation Method". The strain was Staphylococcus aureus (ATCC 6538), and the evaluation was as follows: if the inhibition rate was ≥50% to 90%, it was judged to have an antibacterial effect; if the inhibition rate was ≥90%, it was judged to have a strong antibacterial effect.

[0103] The results are shown in Table 1.

[0104] Table 1 Performance test results

[0105] Moisturizing rate / % Antibacterial rate / % Example 1 91 99 Example 2 88 99 Example 3 90 99 Example 4 83 94 Example 5 85 98 Example 6 86 99 Example 7 80 92 Comparative Example 1 79 88

[0106] It can be seen from the data in Table 1 that the water-soluble human body lubricants of Examples 1-3 have excellent moisturizing properties and antibacterial effects, indicating that the lubricants can provide a long-lasting lubricating effect, do not require frequent reapplication, and can also ensure the shelf life when less preservatives are added, reducing the irritation of preservatives to the human body; It can be seen from Examples 1 and 4 that the addition of fucoidan sulfate can significantly improve the moisturizing properties of the lubricant, which may be due to the fact that fucoidan sulfate has a moisturizing and hygroscopic activity similar to that of sodium hyaluronate, and the two can synergistically prevent glycerol from absorbing moisture when the air is dry; In addition, fucoidan sulfate also affects the antibacterial properties of the lubricant, which may be due to the fact that fucoidan sulfate has a similar moisturizing and hygroscopic activity to ... The lipid structure of polysaccharide sulfate promotes the dissolution of capryloylglycine in water-soluble lubricants; it can be seen from Examples 1 and 5-6 that the water retention of the lubricant is improved by the specific selection of the raw material ratio for synthesizing modified sodium hyaluronate. The possible reason is that the introduced long chains will have some physical entanglement, which is similar to increasing the degree of cross-linking and enhancing the retention and water retention; it can be seen from Examples 1 and 7 that the introduction of sulfonic acid groups in modified sodium hyaluronate can make up for the problem of insufficient water solubility caused by the introduction of monoterpene alcohol, thereby improving the moisturizing rate of the lubricant; it can be seen from Example 1 and Comparative Example 1 that modified sodium hyaluronate can bring antibacterial properties to the lubricant.

[0107] The embodiments described above do not impose any form of limitation on the present invention. Although the present invention has been disclosed as a preferred embodiment as above, it is not intended to limit the present invention. Any technician familiar with the profession can make some changes or modifications to equivalent embodiments of equivalent changes using the technical contents disclosed above without departing from the scope of the technical solution of the present invention. However, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still falls within the scope of the technical solution of the present invention.

Claims

1. A water-soluble personal lubricant suitable for multiple occasions, characterized in that: The composition comprises the following raw materials by weight: 70-84 parts of water, 15-25 parts of moisturizing agent, 0.5-1.5 parts of thickener, 0.5-1 parts of neutralizer, 0.1-0.9 parts of stabilizer and 0.02-0.1 parts of preservative; Wherein, the moisturizing agent comprises modified sodium hyaluronate and glycerin; The stabilizer comprises sodium polyacrylate and EDTA-2Na; The preparation steps of the modified sodium hyaluronate are as follows: S1. Dissolve sodium hyaluronate in deionized water, add 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and adipic acid dihydrazide, adjust the pH to 4-5, stir at room temperature for 1.5-2.5 hours, and after the reaction is completed, adjust the pH to neutral, dialyze with deionized water for 44-52 hours to obtain pretreated sodium hyaluronate; S2, dissolving monoterpene alcohol, succinic anhydride and 4-dimethylaminopyridine in a solvent, adding pyridine under the protection of an inert gas, stirring at room temperature for 20-28 hours, washing and drying after the reaction is completed to obtain a reactant; S3, dissolving the reactant in step S2 in N,N-dimethylformamide, adding 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, stirring for 1-3 hours, adding the pretreated sodium hyaluronate in step S1, stirring at room temperature for 20-28 hours, then adding sulfur trioxide pyridine and stirring at room temperature for 15-25 minutes, and dialyzing with deionized water for 40-60 hours to obtain the modified sodium hyaluronate; The moisturizing agent further comprises propylene glycol, butylene glycol, 1,2-hexanediol and fucoidan sulfate.

2. The water-soluble personal lubricant suitable for multiple occasions according to claim 1, characterized in that: The relative molecular mass of sodium hyaluronate in step S1 is 8000-10000.

3. The water-soluble personal lubricant suitable for multiple occasions according to claim 2, characterized in that: The mass ratio of sodium hyaluronate to adipic acid dihydrazide in step S1 is 1:(1.3-1.42).

4. The water-soluble personal lubricant suitable for multiple occasions according to claim 1, characterized in that: The molar ratio of monoterpene alcohol to succinic anhydride in step S2 is 1:(1.1-1.3).

5. The water-soluble personal lubricant suitable for multiple occasions according to claim 1, characterized in that: The preservatives include caprylhydroxamic acid and capryloylglycine.

6. The water-soluble personal lubricant suitable for multiple occasions according to claim 1, characterized in that: The neutralizing agent comprises triethanolamine.

7. A method for preparing a water-soluble personal lubricant suitable for multiple occasions as claimed in any one of claims 1 to 6, characterized in that: The following steps are involved: A1. Soften water to obtain softened water; A2, stirring the glycerin in the moisturizing agent and the sodium polyacrylate in the stabilizer for 30-70 minutes, degassing, and filtering to obtain component 1; A3. Homogenize the softened water, thickener and the remaining moisturizing agent and stabilizer for 5-10 minutes, stir at 70-90° C. for 20-60 minutes and then degas, add component 1 obtained in step A2, keep warm for 20-40 minutes, cool to below 40° C., add a neutralizer and a preservative, and stir evenly to obtain the water-soluble human lubricant suitable for multiple occasions.

8. The method for preparing a water-soluble personal lubricant suitable for multiple occasions according to claim 7, characterized in that: The conductivity of the softened water in step A1 is ≤5 μs / cm.