A cell reinfusion device

Abstract

The present invention discloses a cell reinfusion device, which relates to the technical field of medical devices. It includes an infusion component, a cell reinfusion control mechanism, a cell reinfusion bag, a cell infusion pump, a cell reinfusion device and a control system. The cell reinfusion control mechanism, the cell infusion pump and the cell reinfusion device are all installed on the infusion component; the cell reinfusion bag is installed in the cell reinfusion control mechanism, the cell reinfusion bag is connected to the cell reinfusion device to realize cell fluid transportation, and the cell infusion pump cooperates with the cell reinfusion device to control the cell fluid infusion; the actions of the cell reinfusion control mechanism, the cell reinfusion bag, the cell infusion pump and the cell reinfusion device are controlled by the control system. The cell reinfusion device of the present invention can realize the automatic swinging of the cell reinfusion bag to prevent cell precipitation.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a cell reinfusion device. Background Art

[0002] Cell transfusion is an important part of cell therapy technology. Currently, cell transfusion bags are mostly used for cell transfusion. However, due to the biological characteristics of cells, cells in the transfusion suspension are prone to clump or stick to the inner wall of the cell transfusion bag. In the worst case, the cells in the cell transfusion bag cannot be completely transfused to the patient, resulting in cell waste. In the worst case, the cell clusters block the blood vessels and cause medical accidents. Under current medical conditions, medical staff often shake the cell solution frequently during cell transfusion, which is labor-intensive and prone to medical accidents due to negligence.

[0003] In addition, there are strict requirements for the flow rate during the reinfusion process. At the beginning of the cell reinfusion, the speed should not be too fast. When the patient feels no discomfort, the flow rate can be gradually increased and the infusion should be completed within the specified time. At present, gravity infusion is used, and the number of drops is observed by human eyes and controlled by the regulator of the cell reinfusion device. The accuracy can only be roughly controlled, and the infusion time cannot be guaranteed, which affects the treatment effect.

[0004] Before cell reinfusion, the cell reinfusion device pipeline needs to be flushed with normal saline; if clumped cells are found on the filter screen of the cell reinfusion device during infusion, it is also necessary to flush it with normal saline before continuing the cell reinfusion; after the cell reinfusion is completed, the reinfusion bag and the cell reinfusion device are rinsed with normal saline to ensure that all cells are entered into the corresponding positions to avoid wasting cells. The frequent use of normal saline requires medical staff to unplug and plug the cell reinfusion device plug and switch between normal saline and the cell reinfusion bag, which is not only troublesome but also prone to secondary contamination. Finally, manually injecting normal saline into the reinfusion bag and shaking it is not only troublesome but also prone to mechanical risks.

[0005] The filters used in ordinary cell reinfusion devices are not suitable for cells, which can easily cause cell agglomeration, blockage, and slow downflow, which in turn affects the cell reinfusion speed. Nurses need to watch over them, sometimes flick the pipes and filters, or flush with saline. When the cells are reinfused, too many medical staff are required to shake the bag, observe the drip rate, detect the patient's vital data, flush with saline, etc., and the risk of problems is high. Summary of the invention

[0006] The present invention aims at solving the problems in the prior art and provides a cell reinfusion device.

[0007] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0008] A cell reinfusion device comprises an infusion assembly, a cell reinfusion control mechanism, a cell reinfusion bag, a cell infusion pump, a cell reinfusion device and a control system, wherein the cell reinfusion control mechanism, the cell infusion pump and the cell reinfusion device are all installed on the infusion assembly; the cell reinfusion bag is installed in the cell reinfusion control mechanism, the cell reinfusion bag is connected to the cell reinfusion device to realize cell fluid transportation, and the cell infusion pump cooperates with the cell reinfusion device to control the cell fluid infusion; the actions of the cell reinfusion control mechanism, the cell reinfusion bag, the cell infusion pump and the cell reinfusion device are controlled by the control system; the cell reinfusion control mechanism is provided with a first pressing bag body module, a second pressing bag body module and a third pressing bag body module; the cell reinfusion bag comprises a first bag body, a second bag body and a third bag body; when the cell reinfusion control mechanism is closed, the first pressing bag body module contacts the third bag body, a virtual welding part is provided at the interval between the second bag body and the third bag body, the second pressing bag body module contacts the virtual welding part, and the third pressing bag body module contacts the first bag body.

[0009] Based on the above technical solution, further, the infusion assembly includes an infusion stand and a fixed base, and the fixed base is installed at the bottom of the infusion stand.

[0010] Based on the above technical solution, further, the cell reinfusion control mechanism is a box structure, including a box bottom and a box cover, and the box bottom and the box cover are movably connected; a swing driving component is provided on the outside of the box bottom, and a first fixed seat is provided on one side of the swing driving component, and the first fixed seat is clamped on the infusion stand; a accommodating space is provided inside the box bottom, and a fixing part and a plurality of fixing buckles are provided in the accommodating space, and a liquid level sensor is provided on the fixing part.

[0011] Based on the above technical solution, further, a swing motor is provided inside the swing driving component, the swing motor is provided with an output shaft, a mounting hole is opened at the bottom of the box, the output shaft is arranged in the mounting hole, and the swing motor is started to drive the output shaft to rotate, and the output shaft rotates to drive the cell reinfusion control mechanism to swing.

[0012] Based on the above technical solution, further, the cell reinfusion bag also includes a cell reinfusion bag body, and the first bag body, the second bag body and the third bag body are arranged on the cell reinfusion bag body at intervals; a plurality of fixing holes are arranged on the cell reinfusion bag body at intervals, and a fixing buckle is installed in each fixing hole, and the cell reinfusion bag is placed in the accommodating space for fixing through the fixing structure of the fixing buckle and the fixing hole.

[0013] Based on the above technical solution, further, the first pressing bag module has a built-in vibration motor.

[0014] Based on the above technical solution, further, the first bag body is provided with a first physiological saline cavity, the second bag body is provided with a second physiological saline cavity, the third bag body is provided with a cell reinfusion cavity, and the first bag body is provided with a first filling port, the third bag body is provided with a third filling port, the second bag body is provided with a second filling port and an infusion port, and the first physiological saline cavity is connected to the first filling port, the cell reinfusion cavity is connected to the third filling port, and the second physiological saline cavity is connected to the second filling port and the infusion port.

[0015] Based on the above technical solution, further, the cell transfusion device includes a puncture filter, a drip bucket, a hose, a flow regulator and a Luer outer cone, wherein the hose passes through the puncture filter, the interior of the drip bucket is connected to the interior of the hose and the drip bucket is located below the puncture filter, the flow regulator is sleeved on the hose and the flow regulator is located below the drip bucket, the Luer outer cone is arranged on the hose and the Luer outer cone is located at the lower end of the flow regulator; the end of the puncture filter is connected to the infusion port.

[0016] Based on the above technical solution, further, the bottom end of the puncture filter is internally a double-layer filter membrane structure, including a first filter membrane and a second filter membrane, the first filter membrane is located above the second filter membrane, and the area of ​​the first filter membrane is smaller than the area of ​​the second filter membrane.

[0017] Based on the above technical solution, further, a second fixing seat is fixedly connected to the side of the cell infusion pump, and the second fixing seat is clamped on the infusion stand.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] (1) The cell reinfusion device of the present invention can realize automatic swinging of the cell reinfusion bag to prevent cell sedimentation, and can be used with a cell infusion pump to fix the rear end of the cell reinfusion device to prevent the cell reinfusion bag from shaking during the swinging process and affecting the safety of cell reinfusion.

[0020] (2) The cell reinfusion device of the cell reinfusion apparatus of the present invention is used in conjunction with a cell infusion pump to set and control the flow rate and infusion time, and a prompt will be given after the infusion is completed.

[0021] (3) The cell reinfusion bag of the cell reinfusion device of the present invention is used in conjunction with the cell reinfusion control mechanism, and physiological saline for flushing and cleaning the remaining cell fluid can be pre-loaded into the cell reinfusion bag to complete the automatic control of flushing the pipeline, cell reinfusion, and cleaning the remaining cell fluid. The cell reinfusion device is fixed by a cell infusion pump to prevent damage to the patient during shaking; the cell reinfusion device only needs to be inserted into the infusion port of the cell reinfusion bag once, and no secondary contamination will be caused by plugging and unplugging. Among them, the cell reinfusion bag adopts a three-chamber bag structure to achieve the connection between physiological saline and cell reinfusion fluid, and is used in conjunction with the cell reinfusion control mechanism, and each bag body can also be shaken and flushed to allow all cells to be infused, avoiding waste and affecting the infusion effect; avoiding repeated punctures, reducing labor, and avoiding infection.

[0022] (4) The cell reinfusion device of the cell reinfusion device of the present invention has a puncture filter that increases the filtration area and adopts a double filtration membrane structure of 40 μm and 200 μm, which effectively prevents cells from clogging the filter, ensures the cell reinfusion flow rate and efficiency, and increases the filtration speed. It is used in conjunction with a cell infusion pump through a hose to achieve the purpose of accurately controlling the infusion speed.

[0023] (5) The system using the cell reinfusion device of the present invention takes into account the entire process of cell reinfusion, and achieves automated control in cell reinfusion flow rate control, cell anti-precipitation, and use of physiological saline, thereby reducing labor costs, improving cell reinfusion efficiency, reducing external risks of cell reinfusion, and ensuring the therapeutic effect of cell reinfusion.

[0024] (6) The present invention can set various parameters of cell reinfusion by setting a control system, which greatly reduces the risk of manual operation, reduces the workload of medical staff and the number of medical staff required, and improves the efficiency of cell fluid reinfusion and the reinfusion treatment effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the overall structure of the cell reinfusion device of the present invention;

[0026] Figure 2 for Figure 1 Schematic diagram of the overall structure of the cell reinfusion control mechanism after it rotates a certain angle;

[0027] Figure 3 It is a three-dimensional structural schematic diagram of the cell reinfusion control mechanism of the present invention;

[0028] Figure 4 It is a schematic diagram of the structure of the cell reinfusion control mechanism of the present invention after being unfolded;

[0029] Figure 5 For the present invention Figure 4 Schematic diagram of the structure in a non-expanded state;

[0030] Figure 6 This is a schematic diagram of the structure of the cell reinfusion bag of the present invention;

[0031] Figure 7 It is a schematic diagram of the structure of the cell infusion pump of the present invention;

[0032] Figure 8 It is a schematic diagram of the structure of the cell reinfusion device of the present invention;

[0033] Fig. 9 for Figure 8 Schematic diagram of the structure of the medium puncture filter;

[0034] Fig.10 for Fig. 9 A schematic cross-sectional view of a medium puncture filter;

[0035] Fig.11 for Fig. 9 Schematic diagram of the structure of each filter membrane inside the puncture filter;

[0036] Figure numerals: 1, infusion stand; 2, fixed base; 3, cell reinfusion control mechanism; 30, observation window; 31, box cover; 32, box bottom; 33, first pressing bag module; 34, second pressing bag module; 35, third pressing bag module; 36, fixed buckle; 37, fixed part; 38, first fixed seat; 39, swing drive; 4, cell reinfusion bag; 40, cell reinfusion bag body; 41, first saline cavity; 42, second saline cavity; 43, cell reinfusion solution Cavity; 44, first filling port; 45, second filling port; 46, third filling port; 47, fixing hole; 48, infusion port; 49, cold soldering part; 5, cell infusion pump; 50, second fixing seat; 51, through hole; 52, key indicator light; 53, touch screen; 54, control button; 6, cell return device; 60, puncture filter; 61, drip bucket; 62, hose; 63, flow regulator; 64, Ruhr outer cone; 65, first filter membrane; 66, second filter membrane; 7, handle. DETAILED DESCRIPTION

[0037] The present invention is further described and illustrated below in conjunction with the accompanying drawings and specific embodiments. The technical features of each embodiment of the present invention can be combined accordingly without conflicting with each other.

[0038] In order to make the above-mentioned purpose, features and advantages of the present invention more obvious and easy to understand, the specific implementation mode of the present invention is described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below. The technical features in each embodiment of the present invention can be combined accordingly without conflicting with each other.

[0039] In the description of the present invention, it is to be understood that when an element is considered to be "connected" to another element, it may be directly connected to the other element or indirectly connected, that is, there are intermediate elements. On the contrary, when an element is said to be "directly" connected to another element, there are no intermediate elements.

[0040] In the description of the present invention, it should be understood that the terms "first" and "second" are only used for the purpose of distinguishing descriptions, and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features.

[0041] Example

[0042] Combination Figure 1 As shown, this embodiment provides a cell reinfusion device, which includes an infusion component, a cell reinfusion control mechanism 3, a cell reinfusion bag 4, a cell infusion pump 5, a cell reinfusion device 6 and a control system; the infusion component includes an infusion stand 1 and a fixed base 2, the fixed base 2 is installed at the bottom of the infusion stand 1, and the fixed base 2 is used to support and fix the infusion stand 1 to keep it stable. The cell reinfusion control mechanism 3, the cell infusion pump 5, and the cell reinfusion device 6 are all installed on the infusion stand 1. The cell reinfusion bag 4 is installed in the cell reinfusion control mechanism 3, the cell reinfusion bag 4 is connected to the cell reinfusion device 6 to realize cell fluid transportation, and the cell infusion pump 5 cooperates with the cell reinfusion device 6 to control the infusion of the cell fluid. Among them, the cell reinfusion control mechanism 3 can fix the cell reinfusion bag 4 and can have the function of automatic swinging, which can prevent cells from agglomerating and clogging, and at the same time, no manual work is required, reducing the workload of medical staff; it can automatically flush the cell reinfusion bag 4 and the pipeline with physiological saline to ensure that the cells are completely transfused into the patient's body, while reducing the workload of medical staff; the built-in liquid level sensor can monitor the pipeline liquid.

[0043] Reference Figure 2-Figure 5As shown, in this embodiment, the cell reinfusion control mechanism 3 is a box structure, including a box bottom 32 and a box cover 31, and the box bottom 32 and the box cover 31 are movably connected, and the connection method can be selected to be hinged or the like. A swing drive member 39 is provided on the outside of the box bottom 32, and the swing drive member 39 is preferably a flat plate structure. A swing motor is provided inside the swing drive member 39, and the swing motor is provided with an output shaft. A mounting hole is provided at the bottom of the box bottom 32, and the output shaft is provided in the mounting hole. By starting the swing motor, the output shaft is driven to rotate, and the rotation of the output shaft drives the cell reinfusion control mechanism 3 fixedly connected to the output shaft through the mounting hole to swing and rotate at a certain angle. Furthermore, a first fixing seat 38 is provided on one side of the swing driving member 39 away from the bottom 32 of the box, and the first fixing seat 38 is clamped on the infusion stand 1. In order to strengthen the connection stability between the first fixing seat 38 and the infusion stand 1, a limiting hole is provided on the side of the first fixing seat 38, and a bolt or other fixing member passes through the limiting hole and abuts against the infusion stand 1 to lock the connection between the first fixing seat 38 and the infusion stand 1. Furthermore, the swing driving member 39 also includes a battery, a power module, a communication connection socket of the cell infusion pump 5, etc., to ensure that the entire device can be started and operated.

[0044] Reference Figure 2-Figure 5 As shown, at least one observation window 30 is provided on the box cover 31, which can be used to observe the internal situation of the box body and protect the cell reinfusion bag 4 from light. In this embodiment, two observation windows 30 are set as an example. Of course, the observation window 30 can also be one, three or even more. For the implementation of one, three or even more observation windows 30, no more details are given here. A handle 7 is also provided on the outer surface of the box cover 31 to facilitate opening the box cover 31; the inner surface of the box cover 31 is independently provided with a first pressing bag body module 33, a second pressing bag body module 34 and a third pressing bag body module 35. In addition to the function of pressing the third bag body to connect the second physiological saline cavity 42 with the cell reinfusion liquid cavity 43 at the weld joint, the first pressing bag body module 33 also has a built-in vibration motor. In the process of flushing, reinfusion and cleaning the remaining cell fluid, the third bag body of the cell reinfusion liquid cavity 43 is vibrated. Combined with the swing of the cell reinfusion control mechanism 3, the precipitation of cells and the attachment to the bag body surface are prevented, solving the blockage problem of cell reinfusion. A accommodating space is provided inside the box bottom 32, and a plurality of fixing buckles 36 are provided in the accommodating space. The fixing buckles 36 are provided to fix the cell return bag 4; and a fixing portion 37 is also provided inside the box bottom 32. The fixing portion 37 is a U-shaped structure, and a liquid level sensor is provided on the fixing portion 37 for monitoring the liquid level.

[0045] Reference Figure 6As shown, in this embodiment, the cell reinfusion bag 4 includes a cell reinfusion bag body 40, a first bag body, a second bag body, and a third bag body, wherein the first bag body is provided with a first physiological saline cavity 41, the second bag body is provided with a second physiological saline cavity 42, and the third bag body is provided with a cell reinfusion liquid cavity 43, the volume of the first physiological saline cavity 41 is preferably 300ml; the volume of the second physiological saline cavity 42 is preferably 100ml; the volume of the cell reinfusion liquid cavity 43 is preferably 200ml, wherein the first bag body, the second bag body and the third bag body are arranged on the cell reinfusion bag body 40 at intervals, and correspondingly, the first bag body is provided with a first infusion liquid cavity 43. The third bag body is provided with a third filling port 46, the second bag body is provided with a second filling port 45 and an infusion port 48, and the first physiological saline cavity 41 is connected to the first filling port 44, the cell reinfusion cavity 43 is connected to the third filling port 46, and the second physiological saline cavity 42 is connected to the second filling port 45 and the infusion port 48; a plurality of fixing holes 47 are provided at intervals on the cell reinfusion bag body 40, and a fixing buckle 36 is installed in the fixing hole 47. The fixing structure of the fixing buckle 36 and the fixing hole 47 can realize that the cell reinfusion bag 4 is placed in the accommodating space of the box bottom 32 of the cell reinfusion control mechanism 3 for fixing. Specifically, the first physiological saline cavity 41 is infused with the corresponding solution through the first filling port 44, the second physiological saline cavity 42 is infused with the corresponding solution through the second filling port 45, and the cell return fluid cavity 43 is infused with the corresponding cell fluid to be infused through the third filling port 46. The infusion socket 48 is used to connect with the cell return transfusion device 6 to perform cell return operation; the middle area where the first physiological saline cavity 41, the second physiological saline cavity 42 and a cell return fluid cavity 43 are connected is a virtual weld, and the cell return fluid cavity 43 and the first physiological saline cavity 41 are squeezed to make the second physiological saline cavity 42 and the cell return fluid cavity 43, and the cell return fluid cavity 43 and the first physiological saline cavity 41 connected in sequence, and each bag body is provided with a capacity scale line, which is convenient for intuitive observation of data. Furthermore, when the box cover 31 and the box bottom 32 are closed, the first pressing bag module 33 located inside the box cover 31 presses on the third bag to contact it, a virtual welding part 49 is provided between the second bag and the cell return infusion cavity 43, the second pressing bag module 34 contacts the virtual welding part 49, and the third pressing bag module 35 contacts the first bag. Specifically, the order of opening the three bags during the infusion process is as follows: first, the saline in the second saline cavity 42 is used to flush the pipeline. Then, the virtual welding connection between the second saline cavity 42 and the cell reinfusion cavity 43 is opened to allow the cell fluid to flow out through the infusion port of the second saline cavity 42. The corresponding working mode of the pressing bag module here is: the second pressing bag module 34 presses the virtual welding port between the first saline cavity 41 and the cell reinfusion cavity 43, and the first pressing bag module 33 presses the cell reinfusion cavity 43 to connect the second saline cavity 42 with the cell reinfusion cavity 43.After the cell fluid infusion in the cell reinfusion fluid cavity 43 is completed, the virtual welding joint between the first saline cavity 41 and the cell reinfusion fluid cavity 43 is opened, and the first saline cavity 41 is used for flushing; the corresponding pressing bag module works as follows: the third pressing bag module 35 presses the first saline cavity 41 to open the virtual welding joint between the first saline cavity 41 and the cell reinfusion fluid cavity 43.

[0046] Reference Figure 7 As shown, the cell infusion pump 5 is provided with a key indicator light 52, a touch screen 53, a control button 54 and a handle 7. In this embodiment, the key indicator light 52 includes at least a power indicator light and a battery indicator light, and the control button 54 includes at least a power button, a start button and a pause button. The side of the cell infusion pump 5 is also fixedly connected with a second fixing seat 50, and the second fixing seat 50 is clamped on the infusion stand 1. In order to strengthen the connection stability between the second fixing seat 50 and the infusion stand 1, a limiting hole is opened on the side of the second fixing seat 50, and a bolt or other fixing member passes through the limiting hole and abuts on the infusion stand 1 to lock the connection between the second fixing seat 50 and the infusion stand 1. Further, the cell infusion pump 5 is also provided with a plurality of communication connection sockets, through which the communication connection sockets can realize the communication process between the cell infusion pump 5 and the cell reinfusion control mechanism 3. Specifically, the cell reinfusion control mechanism 3 supplies power to the cell infusion pump 5 through the communication connection socket, and controls the entire cell reinfusion action through the touch screen 53 and the control button 54 of the cell infusion pump 5. The cell infusion pump 5 is provided with a cell flow control module composed of a peristaltic pump, and the cell flow control module cooperates with the hose 62 of the cell reinfusion device 6 to control the infusion of cell fluid. At the same time, the cell flow control module is also provided with a capacitive sensor for detecting the liquid level and a pressure sensor for detecting the pressure in the hose 62. The cell infusion pump 5 is also provided with a through hole 51, and the capacitive sensor and the pressure sensor are arranged in the through hole 51. The cell infusion pump 5 can not only control the infusion speed, but also prevent the mechanical danger caused by the swing of the hose 62 of the cell reinfusion device 6 during the swinging process of the cell reinfusion control mechanism 3; the built-in liquid level sensor can monitor the pipeline liquid; the pressure sensor can monitor the pipeline pressure.

[0047] Reference Figure 8-Figure 11As shown, the cell reinfusion device 6 includes a puncture filter 60, a drip bucket 61, a hose 62, a flow regulator 63 and a Luer outer cone 64. In this embodiment, the hose 62 passes through the puncture filter 60, the inside of the drip bucket 61 is connected to the inside of the hose 62 and the drip bucket 61 is located below the puncture filter 60, the flow regulator 63 is sleeved on the hose 62 and the flow regulator 63 is located below the drip bucket 61, and the Luer outer cone 64 is arranged on the hose 62 and the Luer outer cone 64 is located at the lower end of the flow regulator 63. Among them, the end of the puncture filter 60 is connected to the infusion socket 48 to transport the cell fluid into the patient's body, and the end of the puncture filter 60 is limited in the U-shaped structure. Specifically, the bottom end area of ​​the puncture filter 60 is the largest, and the bottom end is provided with an inner and outer double-layer filter membrane, which is set as a first filter membrane 65 and a second filter membrane 66. The first filter membrane 65 is located inside the second filter membrane 66. The area of ​​the first filter membrane 65 is smaller than the area of ​​the second filter membrane 66. The folded area of ​​the second filter membrane 66 is smaller than the bottom end area of ​​the filter. Further, the first filter membrane 65 is a 40um filter membrane, and the second filter membrane 66 is a 200um filter membrane. The purpose of setting the double-layer filter membrane is to prevent cell blockage and improve the filtering capacity. The hose 62 is made of silicone, and the silicone hose 62 is used in conjunction with the cell infusion pump 5 to control the cell infusion speed.

[0048] In this embodiment, the control system is an external control end, wherein the control system has the function of controlling the entire reinfusion device, and the control end includes a control screen, on which the process data of the reinfusion device is visualized. The control system can set the saline of the cell reinfusion bag 4, the preset amount of the cell reinfusion bag 4; the speed of each stage and the total time during the cell reinfusion process; monitor the liquid level state of the cell reinfusion bag 4, the liquid level state of the pipeline, and the pipeline infusion pressure; automatically open the virtual welding position between the cavities of the cell reinfusion bag 4 through the cooperation between the three pressing bag body modules, realize the functions of saline flushing pipeline, cell reinfusion, saline flushing of the cell reinfusion bag 4 and pipeline shaking of the cell reinfusion bag 4 infusion; can control the swing speed and angle of the fixing mechanism of the cell reinfusion bag 4.

[0049] The whole process of this device is:

[0050] First, fill the cell fluid and physiological saline into the cell reinfusion bag 4: fill the physiological saline into the first physiological saline cavity 41 and the second physiological saline cavity 42 through the first filling port 44 and the second filling port 45 respectively, and fill the cell fluid into the cell reinfusion cavity 43 through the third filling port 46 respectively.

[0051] Second, fix the cell reinfusion bag 4 in the accommodation space provided inside the box bottom 32 of the cell reinfusion control mechanism 3: In this embodiment, the four fixing holes 47 on the physiological saline cavity in the cell reinfusion bag 4 are fixed to the four fixing buckles 36 of the corresponding number provided in the accommodation space, and the box cover 31 is closed to complete the fixation.

[0052] Third, the process of connecting the cell infusion device 6: initialize the flow of the flow regulator 63 of the cell infusion device to zero, insert the puncture filter 60 of the cell infusion device 6 into the infusion port 48 of the cell infusion bag 4, pass the partial hose 62 of the cell infusion device through the through hole 51 of the cell infusion pump 5, and then adjust the flow regulator 63 to the maximum.

[0053] Fourth, control system setting process: press the power button of the cell infusion pump 5 to start the cell reinfusion device. The control system detects that the cell reinfusion bag 4 has been installed in place through the liquid level sensor of the cell reinfusion control mechanism 3, and detects that the cell reinfusion device 6 is installed in place through the capacitance sensor and pressure sensor of the cell infusion pump 5, and starts to set the relevant parameters, among which, the flushing line speed range is preferably set to 1-800ml / h, the cell washing speed range is preferably set to 1-200ml / h, and the reinfusion speed range is preferably set to 1-200ml / h; in this embodiment, according to the requirements of cell reinfusion, it is necessary to slow first and then fast, and both slow and fast speeds can be set; the total infusion time range is preferably set to 0-2h, the preset amount range is preferably set to 0-200ml, the swing speed range is preferably set to 0-30 rpm, and the swing angle range is preferably 60°-180°. After the settings are completed, click Start.

[0054] Fifth, the process of flushing the pipeline: first, the cell reinfusion device 6 is inserted into the infusion socket 48. After the second saline cavity 42 connected to the infusion socket 48 is plugged in, the cell infusion pump 5 is used to use the saline in the second saline cavity 42 to flush the hose 62 of the cell reinfusion device 6. When the liquid level sensor of the cell reinfusion control mechanism 3 detects that the second saline cavity 42 has been used up, the control screen of the control system prompts that the pipeline flushing is completed. The medical staff uses the Luer outer cone 64 of the cell reinfusion device 6 to connect with other infusion devices and prepare to infuse the patient.

[0055] Sixth, cell reinfusion process: After the cell reinfusion device 6 is connected to the patient, the medical staff clicks the control screen of the control system to confirm the start of cell reinfusion, and the control system controls the first pressing bag module 33 of the cell reinfusion control mechanism 3 to squeeze the cell reinfusion liquid cavity 43, and the second pressing bag module 34 squeezes the virtual welding position between the first physiological saline cavity 41 and the cell reinfusion liquid cavity 43, the purpose of which is to prevent the first pressing bag module 33 from squeezing the cell reinfusion liquid cavity 43 and connecting the first physiological saline cavity 41, thereby connecting the second physiological saline cavity 42 and the cell reinfusion liquid cavity 43. The cavity 43 is connected, and the cell fluid flows into the infusion socket 48, and first passes through the transfer filter of the cell reinfusion device 6 for coarse filtration and fine filtration from the outside to the inside, wherein the first filter membrane 65 performs fine filtration, which can filter particles of 40 μm in size, and the second filter membrane 66 performs coarse filtration, which can filter particles of 200 μm in size, and then is infused into the patient's body through the cell infusion pump 5 and the hose 62. The cell infusion pump 5 first uses the set slow speed to return the cells, and after the medical staff confirms that the patient data is normal, clicks the touch screen 53 to fast, and then performs rapid infusion.

[0056] Seventh, the process of cleaning the remaining cell fluid: when the set infusion time is reached or the preset infusion amount is reached or the liquid level sensor detects that the cell fluid infusion is completed, the control system stops the cell reinfusion and prompts that the cell reinfusion is completed. After the medical staff confirms, click to clean the remaining cell fluid. The system controls the second pressing bag module 34 pressed at the virtual welding position between the second saline cavity 42 and the cell reinfusion cavity 43 to lift up, and the third pressing bag module 35 squeezes the first saline cavity 41 to connect the first saline cavity 41 with the cell reinfusion cavity 43. At this time, the swinging angle and speed are accelerated. After the cell fluid in the cell reinfusion bag 4 is evenly mixed with the saline, the swinging speed is slowed down, and the cell infusion pump 5 starts to work and infuse according to the set cell cleaning speed.

[0057] Eighth, cell reinfusion is completed: When the system detects that there is no liquid in the pipeline through the liquid level sensor of the cell reinfusion control mechanism 3 and the liquid level sensor of the cell infusion pump 5, the system touch screen 53 prompts that the cell reinfusion is completed. After confirmation by the medical staff, the Luer outer cone 64 of the cell reinfusion device 6 is disconnected from other infusion devices, and the remaining post-infusion care is carried out to observe whether the patient has any adverse reactions.

[0058] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A cell reinfusion device, characterized in that: It includes an infusion component, a cell reinfusion control mechanism, a cell reinfusion bag, a cell infusion pump, a cell reinfusion device and a control system. The cell reinfusion control mechanism, the cell infusion pump and the cell reinfusion device are all installed on the infusion component; The cell reinfusion bag is installed in the cell reinfusion control mechanism, the cell reinfusion bag is connected to the cell reinfusion device to realize cell fluid delivery, and the cell infusion pump cooperates with the cell reinfusion device to control the cell fluid infusion; Controlling the actions of the cell reinfusion control mechanism, the cell reinfusion bag, the cell infusion pump, and the cell reinfusion device through the control system; The cell reinfusion control mechanism is provided with a first pressing bag body module, a second pressing bag body module and a third pressing bag body module; the cell reinfusion bag comprises a first bag body, a second bag body and a third bag body; when the cell reinfusion control mechanism is closed, the first pressing bag body module contacts the third bag body, a virtual welding part is provided at the interval between the second bag body and the third bag body, the second pressing bag body module contacts the virtual welding part, and the third pressing bag body module contacts the first bag body; Wherein, the infusion assembly comprises an infusion stand and a fixed base, and the fixed base is installed at the bottom of the infusion stand; The cell reinfusion control mechanism is a box structure, including a box bottom and a box cover, which are movably connected; a swing driving member is provided on the outside of the box bottom, a first fixing seat is provided on one side of the swing driving member, and the first fixing seat is clamped on the infusion stand; a receiving space is provided inside the box bottom, a fixing part and a plurality of fixing buckles are provided in the receiving space, and a liquid level sensor is provided on the fixing part; The swing drive component is provided with a swing motor inside, the swing motor is provided with an output shaft, a mounting hole is provided at the bottom of the box, the output shaft is arranged in the mounting hole, the swing motor is started to drive the output shaft to rotate, and the output shaft rotates to drive the cell reinfusion control mechanism to swing.

2. The cell reinfusion device according to claim 1, characterized in that: The cell reinfusion bag also includes a cell reinfusion bag body, on which the first bag body, the second bag body and the third bag body are arranged at intervals; a plurality of fixing holes are arranged at intervals on the cell reinfusion bag body, and a fixing buckle is installed in each fixing hole. The cell reinfusion bag is placed in the accommodating space and fixed through the fixing structure of the fixing buckle and the fixing hole.

3. The cell reinfusion device according to claim 1, characterized in that: The first pressing bag module has a built-in vibration motor.

4. The cell reinfusion device according to claim 1, characterized in that: The first bag body is provided with a first physiological saline cavity, the second bag body is provided with a second physiological saline cavity, the third bag body is provided with a cell reinfusion cavity, the first bag body is provided with a first filling port, the third bag body is provided with a third filling port, the second bag body is provided with a second filling port and an infusion port, the first physiological saline cavity is connected to the first filling port, the cell reinfusion cavity is connected to the third filling port, and the second physiological saline cavity is connected to the second filling port and the infusion port.

5. The cell reinfusion device according to claim 4, characterized in that: The cell reinfusion device includes a puncture filter, a drip bucket, a hose, a flow regulator and a Luer outer cone, wherein the hose passes through the puncture filter, the interior of the drip bucket is connected to the interior of the hose and the drip bucket is located below the puncture filter, the flow regulator is sleeved on the hose and the flow regulator is located below the drip bucket, the Luer outer cone is arranged on the hose and the Luer outer cone is located at the lower end of the flow regulator; the end of the puncture filter is connected to the infusion socket.

6. The cell reinfusion device according to claim 5, characterized in that: The bottom end of the puncture filter has a double-layer filter membrane structure, including a first filter membrane and a second filter membrane. The first filter membrane is located above the second filter membrane, and the area of ​​the first filter membrane is smaller than that of the second filter membrane.

7. The cell reinfusion device according to claim 1, characterized in that: A second fixing seat is fixedly connected to the side of the cell infusion pump, and the second fixing seat is clamped on the infusion stand.

Images