A pulsed electric field ablation device for hypertrophic cardiomyopathy

Abstract

The present invention belongs to the technical field of pulsed electric field ablation for thick cardiomyopathy, specifically a pulsed electric field ablation device for hypertrophic cardiomyopathy, comprising a pulse generator, a flexible catheter fixedly installed on one side of the pulse generator, and a sliding member slidably connected to the outer surface of the flexible catheter. Through the setting of an auxiliary ablation component, a real-time three-dimensional echocardiogram can be generated during the ablation process. The three-dimensional echocardiogram can provide doctors with clearer cardiac structure images, thereby facilitating doctors to better determine the area of ​​hypertrophic myocardium. Through the internal artificial intelligence and machine learning algorithms of the high-speed analog-to-digital converter, data analysis is performed on the hearts of a large number of patients to generate personalized heart models to assist doctors in precise positioning, thereby reducing the number of times the position of the PFAD electrode catheter is adjusted, shortening the time required for doctors during surgery and reducing the difficulty of surgical treatment.

Description

Technical Field

[0001] The invention belongs to the technical field of pulse electric field ablation of hypertrophic cardiomyopathy, in particular to a pulse electric field ablation device for hypertrophic cardiomyopathy. Background Art

[0002] Hypertrophic cardiomyopathy (HCM) is a myocardial disease of unknown cause, characterized by asymmetric hypertrophy of the ventricular wall, often invading the ventricular septum, smaller ventricular cavity, obstructed left ventricular blood filling, and decreased left ventricular diastolic compliance. According to the presence or absence of obstruction in the left ventricular outflow tract, it is divided into obstructive and non-obstructive hypertrophic cardiomyopathy, which may be related to genetics. Hypertrophic cardiomyopathy has a risk of sudden death and is one of the causes of sudden death during exercise. Hypertrophic cardiomyopathy is an autosomal dominant hereditary disease, 60% to 70% of which are familial and 30% to 40% are sporadic. Familial cases and sporadic cases, pediatric cases and adult cases have the same pathogenic gene mutations. It has been confirmed that at least 14 gene mutations are associated with the onset of hypertrophic cardiomyopathy, 10 of which are genes encoding sarcomere structural proteins, and most mutations are located in these genes.

[0003] During use of the existing pulsed field ablation device for thick cardiomyopathy, the doctor is required to accurately place the ablation component in the area of ​​hypertrophic myocardium and then perform precise ablation. This method greatly tests the doctor's surgical skills. The constant beating of the patient's heart and the differences in individual anatomical structures increase the difficulty of ablation positioning. It may be necessary to adjust the position of the PFAD electrode catheter multiple times, which prolongs the time used by the doctor during the operation and increases the difficulty of surgical treatment. Summary of the invention

[0004] In order to make up for the deficiencies of the prior art, at least one technical problem raised in the background technology is solved.

[0005] The technical solution adopted by the present invention to solve its technical problem is: a pulse electric field ablation device for hypertrophic cardiomyopathy described in the present invention comprises a pulse generator, a flexible catheter is fixedly installed on one side of the pulse generator, a sliding member is provided on the outer surface of the flexible catheter for sliding connection, a fixing member is provided on the outer surface of the flexible catheter, a plurality of PFAD electrode catheters are fixedly installed in a circular array between the sliding member and the fixing member, a plurality of pulse electrode sheets are provided on the outer surfaces of the plurality of PFAD electrode catheters, an auxiliary ablation component is provided on the surface of the pulse generator and the flexible catheter, a traction control component is provided on the surface of the flexible catheter, and a perfusion component is provided on the outer surface of the PFAD electrode catheter;

[0006] The auxiliary ablation component includes an electric field sensor arranged on one side surface of several pulse electrode sheets, temperature sensors are fixedly installed on the other side surfaces of several pulse electrode sheets, several temperature sensors are fixedly installed on the outer surface of the PFAD electrode catheter, several first pressure sensors are arranged on the outer surfaces of several PFAD electrode catheters, several reflective marking layers are arranged on the outer surfaces of several PFAD electrode catheters, a second pressure sensor is arranged at one end of the flexible catheter, an articulated clamping ring is arranged on the outer surface of the flexible catheter, side blocks are fixedly installed on both sides of the outer surface of the articulated clamping ring, an optical camera is fixedly installed on the upper surface of the side block, an annular groove is opened on the outer surface of the flexible catheter, an electric slip ring is arranged on the inner bottom wall of the annular groove, an electric slider is electrically and slidably connected inside the electric slip ring, an ultrasonic probe is arranged on the upper surface of the electric slider, and the articulated clamping rings are mutually limitedly connected by bolts;

[0007] A storage cavity is provided inside the pulse generator, and a mounting plate is provided on the inner wall of the storage cavity. A signal processing circuit board, a communication circuit board and a power management circuit board are provided on the surface of the mounting plate. The processing circuit board, the communication circuit board and the power management circuit board are electrically connected. The internal components of the auxiliary ablation component are connected to the power management circuit board through wires.

[0008] As a preferred technical solution of the present application, the signal processing circuit board includes a high-speed analog-to-digital converter arranged on the surface of the mounting board, and the high-speed analog-to-digital converter is internally provided with artificial intelligence and machine learning algorithms. The high-speed analog-to-digital converter is used to convert analog signals into digital signals, and digitize, reconstruct and enhance the signals of the ultrasound probe to improve the quality and resolution of the image. A digital signal processor and a memory are arranged on one side of the high-speed analog-to-digital converter, and the digital signal processor and the memory are used to decode and calculate the coordinates of the second pressure sensor and the first pressure sensor signals to determine the exact positions of the pulse electrode sheet and the PFAD electrode catheter in the heart.

[0009] As a preferred technical solution of the present application, the communication circuit board includes a communication interface chip and a protocol stack chip arranged on the surface of the mounting board. A display is arranged on the upper surface of the pulse generator. The display is electrically connected to the communication circuit board. The communication interface chip and the protocol stack chip convert the signal processed by the signal processing circuit board into the inside of the display. The doctor can observe the surgical situation in real time. One side of the communication interface chip is electrically connected to a cable interface through a wire, and the cable interface is fixedly installed on the side surface of the pulse generator.

[0010] As a preferred technical solution of the present application, the traction control component includes guide wires arranged on both sides of the inner wall of the flexible conduit, guide wheels are slidably connected to both sides of the outer surface of the flexible conduit, connecting frames are connected to both sides of the outer surface of the guide wheels, connecting rods are rotatably connected to both sides of the outer surface of the connecting frame, and a rotating plate is fixedly installed on the other end of the connecting rod.

[0011] As a preferred technical solution of the present application, a clamping column is fixedly installed on one side surface of the rotating plate, one end of the clamping column is rotatably connected to a clamping cylinder, the clamping cylinder is fixedly installed on the outer surface of the flexible conduit, a fixed clamping ring is provided on the outer surface of the flexible conduit, a clamping plate is fixedly installed on the lower surface of the fixed clamping ring, and the interior of the clamping plate is rotatably connected to a rotating shaft.

[0012] As a preferred technical solution of the present application, damping plates are fixedly installed on both side surfaces of the rotating shaft, and the damping plates are tightly attached to the side surfaces of the clamping plate. Transmission wheels are fixedly installed on the outer surfaces of the rotating shaft and the clamping column, and a transmission belt is overlapped on the outer surface of the transmission wheel. A rotating handle is fixedly installed on one end of the rotating shaft.

[0013] As a preferred technical solution of the present application, the perfusion assembly includes a first water pipe arranged on the side surface of several PFAD electrode catheters, several nozzles are arranged on the surface of the first water pipe, a guide ring is fixedly installed at one end of the first water pipe, and the guide ring is rotatably connected to the outer surface of the PFAD electrode catheter, a corrugated hose is fixedly installed at one end of the first water pipe, and several of the corrugated hoses are fixedly installed at one end with telescopic water pipes, one end of the telescopic water pipe is provided with a water injection pipe, and the water injection pipe is arranged on the outer surface of the flexible catheter.

[0014] As a preferred technical solution of the present application, the lower surface of the sliding member is rotatably connected to a plurality of driven gears and a driving gear ring, a first water pipe is fixedly installed on the lower surface of the driven gear, one side of a plurality of the driven gears is meshingly connected to the driving gear ring, an electromagnetic coil is arranged inside the sliding member, the electromagnetic coil is electrically connected to a power management circuit board through a wire, and a rotor is arranged on the inner side wall of the driving gear ring.

[0015] As a preferred technical solution of the present application, the auxiliary ablation component also includes a storage box arranged on the side surface of the pulse generator, the inner wall of the storage box is connected to a telescopic frame, one end of the telescopic frame is rotatably connected to a magnetic field generator, and the surface of the storage box is rotatably connected to a protective cover.

[0016] The beneficial effects of the present invention are as follows:

[0017] 1. The pulsed electric field ablation device for hypertrophic cardiomyopathy described in the present invention can generate real-time three-dimensional echocardiography during the ablation process through the setting of the auxiliary ablation component. The three-dimensional echocardiography can provide doctors with clearer cardiac structural images, so that doctors can better determine the area of ​​hypertrophic myocardium. The high-speed analog-to-digital converter's internal artificial intelligence and machine learning algorithms can be used to perform data analysis on the hearts of a large number of patients to generate personalized heart models to assist doctors in accurate positioning, thereby reducing the number of times the PFAD electrode catheter position is adjusted, shortening the time required by doctors during surgery and reducing the difficulty of surgical treatment;

[0018] 2. The pulsed electric field ablation device for hypertrophic cardiomyopathy described in the present invention, through the setting of the traction control component, can drive the rotating shaft to rotate by turning the rotating handle, and the flexible catheter can be effectively bent under the moving guide wheel through the transmission pulley, and the internal guide wire can effectively support the flexible catheter, and the guide wire can be bent, which is convenient for doctors to stably control the bending degree of the flexible catheter, so that the PFAD electrode catheter and the pulse electrode sheet can smoothly and stably enter the right ventricle from the right atrium, thereby improving the doctor's surgical efficiency;

[0019] 3. The pulse electric field ablation device for hypertrophic cardiomyopathy described in the present invention, through the setting of the perfusion component, first energizes the electromagnetic coil to make the first water pipe rotate from the inner wall to the outer wall, and the nozzle is aimed at the hypertrophic myocardial area, and physiological saline is input into the telescopic water pipe through the water injection pipe with a suitable pressure, so that the physiological saline is sprayed on the hypertrophic myocardial area, thereby improving the conductivity of the local tissue at the ablation site, improving the consistency and effect of the ablation, and at the same time having a cooling effect, reducing tissue overheating, lowering tissue temperature, and reducing the risk of thermal damage. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The present invention will be further described below in conjunction with the accompanying drawings.

[0021] Figure 1 is a stereogram of the present invention;

[0022] Figure 2 is a schematic structural diagram of a first part of the perfusion assembly of the present invention;

[0023] Figure 3 is a schematic structural diagram of a second part of the perfusion assembly of the present invention;

[0024] Figure 4 is a schematic structural diagram of a first part of the auxiliary ablation component in the present invention;

[0025] Figure 5 The present invention Figure 4A schematic diagram of the enlarged structure at A in the middle;

[0026] Figure 6 is a schematic diagram of the structure of the traction control component in the present invention from a first perspective;

[0027] Figure 7 is a schematic diagram of the structure of the traction control component in the present invention from a second viewing angle;

[0028] Figure 8 is a second partial structural schematic diagram of the auxiliary ablation component in the present invention;

[0029] Fig. 9 It is a structural schematic diagram of the telescopic frame and the magnetic field generator in the present invention.

[0030] In the figure:

[0031] 1. Pulse generator; 2. Flexible catheter; 3. Sliding part; 4. PFAD electrode catheter; 5. Pulse electrode sheet;

[0032] 6. Auxiliary ablation component; 602. Temperature sensor; 603. First pressure sensor; 604. Reflective marking layer; 605. Second pressure sensor; 606. Optical camera; 607. Electric slip ring; 608. Ultrasound probe; 609. Signal processing circuit board; 610. Communication circuit board; 611. Power management circuit board; 612. Cable interface; 613. Telescopic frame; 614. Magnetic field generator; 615. Display;

[0033] 7. Traction control assembly; 701. Guide wire; 702. Guide wheel; 703. Connecting frame; 704. Connecting rod; 705. Rotating plate; 706. Fixed snap ring; 707. Rotating shaft; 708. Damping sheet;

[0034] 8. Infusion assembly; 801. First water pipe; 802. Nozzle; 803. Guide ring; 804. Corrugated hose; 805. Telescopic water pipe; 806. Driven gear; 807. Drive gear ring; 808. Electromagnetic coil. DETAILED DESCRIPTION

[0035] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0036] Embodiment 1:

[0037] like Figures 1 to 9As shown, a pulse electric field ablation device for hypertrophic cardiomyopathy described in an embodiment of the present invention comprises a pulse generator 1, a flexible catheter 2 is fixedly installed on one side of the pulse generator 1, a sliding member 3 is slidably connected to the outer surface of the flexible catheter 2, a fixing member is provided on the outer surface of the flexible catheter 2, a plurality of PFAD electrode catheters 4 are fixedly installed in a circular array between the sliding member 3 and the fixing member, a plurality of pulse electrode sheets 5 are provided on the outer surfaces of the plurality of PFAD electrode catheters 4, an auxiliary ablation component 6 is provided on the surface of the pulse generator 1 and the flexible catheter 2, a traction control component 7 is provided on the surface of the flexible catheter 2, and a perfusion component 8 is provided on the outer surface of the PFAD electrode catheter 4;

[0038] The auxiliary ablation component 6 includes an electric field sensor arranged on one side surface of several pulse electrode sheets 5, and temperature sensors 602 are fixedly installed on the other side surfaces of several pulse electrode sheets 5. Several temperature sensors 602 are fixedly installed on the outer surface of the PFAD electrode catheter 4, and several first pressure sensors 603 are arranged on the outer surfaces of several PFAD electrode catheters 4. Several reflective marking layers 604 are arranged on the outer surfaces of several PFAD electrode catheters 4. A second pressure sensor 605 is arranged at one end of the flexible catheter 2, and an articulated clamping ring is arranged on the outer surface of the flexible catheter 2. Side blocks are fixedly installed on both sides of the outer surface of the articulated clamping ring, and an optical camera 606 is fixedly installed on the upper surface of the side block. An annular groove is opened on the outer surface of the flexible catheter 2, and an electric slip ring 607 is arranged on the inner bottom wall of the annular groove. The electric slip ring 607 is electrically and slidably connected to an electric slider inside, and an ultrasonic probe 608 is arranged on the upper surface of the electric slider. The articulated clamping rings are mutually limitedly connected by bolts.

[0039] A storage cavity is provided inside the pulse generator 1, and a mounting plate is provided on the inner wall of the storage cavity. A signal processing circuit board 609, a communication circuit board 610 and a power management circuit board 611 are provided on the surface of the mounting plate. The processing circuit board 609, the communication circuit board 610 and the power management circuit board 611 are electrically connected, and the internal components of the auxiliary ablation component 6 are connected to the power management circuit board 611 through wires.

[0040] The signal processing circuit board 609 includes a high-speed analog-to-digital converter arranged on the surface of the mounting board. The high-speed analog-to-digital converter is internally provided with artificial intelligence and machine learning algorithms. The high-speed analog-to-digital converter is used to convert analog signals into digital signals, and digitize, reconstruct and enhance the signals of the ultrasound probe 608 to improve the quality and resolution of the image. A digital signal processor and a memory are arranged on one side of the high-speed analog-to-digital converter. The digital signal processor and the memory are used to decode and calculate the coordinates of the signals of the second pressure sensor 605 and the first pressure sensor 603 to determine the exact positions of the pulse electrode sheet 5 and the PFAD electrode catheter 4 in the heart.

[0041] The communication circuit board 610 includes a communication interface chip and a protocol stack chip arranged on the surface of the mounting plate. A display 615 is arranged on the upper surface of the pulse generator 1. The display 615 is electrically connected to the communication circuit board 610. The communication interface chip and the protocol stack chip convert the signal processed by the signal processing circuit board 609 into the display 615. The doctor can observe the surgical situation in real time. One side of the communication interface chip is electrically connected to the cable interface 612 through a wire. The cable interface 612 is fixedly installed on the side surface of the pulse generator 1.

[0042] The auxiliary ablation component 6 also includes a storage box arranged on the side surface of the pulse generator 1. The inner wall of the storage box is connected to a telescopic frame 613. One end of the telescopic frame 613 is rotatably connected to a magnetic field generator 614. The surface of the storage box is rotatably connected to a protective cover.

[0043] In this embodiment: the operator inserts the flexible catheter 2 into the patient's heart, and the second pressure sensor 605 at the bottom detects the pressure during insertion, thereby helping the doctor to determine whether the catheter is in the correct position to avoid damage caused by excessive insertion. The electric slip ring 607 at the bottom is started to drive the internal electric slider and the ultrasonic probe 608 on the upper surface to rotate, thereby providing a full range of three-dimensional images of the heart. The ultrasonic probe 608 inputs data into the signal processing board 609, and then displays the three-dimensional image of the heart through the display 615, which can provide a real-time three-dimensional image of the heart, can clearly display the myocardial structure and blood flow, has a high frame rate and high resolution, and can dynamically observe the heart;

[0044] After the hypertrophic myocardial part is detected, the PFAD electrode catheter 4 is in a bent state by squeezing and sliding the sliding member 3, and the PFAD electrode catheter 4 and the pulse electrode sheet 5 on the surface are closely attached to the hypertrophic myocardial part. During the ablation process, the temperature sensor 602 can detect that the temperature rise may cause tissue damage during the pulse electric field ablation process. The temperature sensor 602 can provide real-time temperature feedback to help control the ablation energy and prevent overheating. It has a rapid response capability so as to adjust the ablation parameters in time. The first pressure sensor 603 is used to detect the contact pressure between the catheter and the myocardial tissue, which can help the doctor determine whether the position of the PFAD electrode catheter 4 is correct and avoid damage caused by excessive insertion. Since the reflective marking layer 604 is set on the surface of the PFAD electrode catheter 4, the reflective marking layer 604 and the position of the PFAD electrode catheter 4 can be captured by the optical camera 606, so as to calculate the position of the PFAD electrode catheter 4, and then the data is converted into coordinates through the signal processing circuit board 609 and displayed through the display 615, which is convenient for the doctor to perform the operation. The communication circuit board 610 can transmit the image, position and sensor data processed by the signal processing circuit board 609 to the surgical navigation display system for the doctor to observe and make decisions in real time.

[0045] Before the operation, it is necessary to open the storage box and take out the magnetic field generator 614 inside through the telescopic frame 613. At the same time, the telescopic frame 613 is adjusted to place the magnetic field generator 614 above the operation. The magnetic field generator 614 cooperates with the electric field sensor to detect the electric field distribution around the PFAD electrode catheter 4, help determine the range and intensity of the ablation area, and provide real-time electric field information to assist surgical personnel in adjusting ablation parameters and achieve precise ablation.

[0046] Embodiment 2:

[0047] like Figures 1 to 9 As shown, the traction control component 7 includes a guide wire 701 arranged on both sides of the inner wall of the flexible conduit 2, both sides of the outer surface of the flexible conduit 2 are slidably connected with a guide wheel 702, both sides of the outer surface of the guide wheel 702 are connected with a connecting frame 703, both sides of the outer surface of the connecting frame 703 are rotatably connected with a connecting rod 704, and the other end of the connecting rod 704 is fixedly installed with a rotating plate 705.

[0048] A clamping column is fixedly installed on one side surface of the rotating plate 705, one end of which is rotatably connected to a clamping cylinder, which is fixedly installed on the outer surface of the flexible catheter 2. A fixed clamping ring 706 is provided on the outer surface of the flexible catheter 2, and a clamping plate is fixedly installed on the lower surface of the fixed clamping ring 706, and a rotating shaft 707 is rotatably connected to the inside of the clamping plate.

[0049] Damping plates 708 are fixedly installed on both side surfaces of the rotating shaft 707, and the damping plates 708 are tightly attached to the side surfaces of the clamping plate. Transmission wheels are fixedly installed on the outer surfaces of the rotating shaft 707 and the clamping column, and a transmission belt is overlapped on the outer surface of the transmission wheel. A rotating handle is fixedly installed on one end of the rotating shaft 707.

[0050] In this embodiment: when the pulse part moves from the right atrium to the right ventricle, it is necessary to adjust the bending direction of the flexible catheter 2. The surgeon drives the rotating shaft 707 to rotate by rotating the handle. The rotation of the rotating shaft 707 drives the damping plate 708 to rotate inside the card plate. The damping plate 708 is relatively stable after the rotation stops due to the high friction force. The rotating shaft 707 rotates the rotating plate 705 on the other side through the transmission wheel and the transmission belt. The rotating plate 705 drives the connecting frame 703 to rotate through the connecting rod 704. The connecting frame 703 drives the guide wheel 702 to move. The guide wheel 702 slides on the surface of the flexible catheter 2 and adjusts the bending direction of the flexible catheter 2. The internal guide wire 701 can effectively support the flexible catheter 2, and the guide wire 701 can be bent, which is convenient for the doctor to stably control the bending degree of the flexible catheter 2, so that the PFAD electrode catheter 4 and the pulse electrode sheet 5 can smoothly and stably enter the right ventricle from the right atrium, thereby improving the doctor's surgical efficiency.

[0051] Embodiment three:

[0052] like Figures 1 to 9 As shown, the perfusion assembly 8 includes a first water pipe 801 arranged on the side surface of several PFAD electrode catheters 4, and several nozzles 802 are arranged on the surface of the first water pipe 801. A guide ring 803 is fixedly installed at one end of the first water pipe 801, and the guide ring 803 is rotatably connected to the outer surface of the PFAD electrode catheter 4. A corrugated hose 804 is fixedly installed at one end of the first water pipe 801, and telescopic water pipes 805 are fixedly installed at one end of several corrugated hoses 804. A water injection pipe is arranged at one end of the telescopic water pipe 805, and the water injection pipe is arranged on the outer surface of the flexible catheter 2.

[0053] The lower surface of the sliding member 3 is rotatably connected to a plurality of driven gears 806 and a driving gear ring 807, a first water pipe 801 is fixedly installed on the lower surface of the driven gear 806, one side of the plurality of driven gears 806 is meshingly connected to the driving gear ring 807, an electromagnetic coil 808 is arranged inside the sliding member 3, the electromagnetic coil 808 is electrically connected to the power management circuit board 611 through a wire, and a rotor is arranged on the inner wall of the driving gear ring 807.

[0054] In this embodiment: before pulse ablation, the electromagnetic coil 808 is energized through the wire, and the electromagnetic coil 808 generates magnetic force to drive the rotor to rotate, and the rotor drives the driving gear ring 807 to rotate, and the driving gear ring 807 rotates the driven gear 806 engaged on the outer surface to rotate, and the driven gear 806 drives the first water pipe 801 below to rotate, and the first water pipe 801 rotates on the outer surface of the flexible catheter 2 through the guide ring 803, and the first water pipe 801 is rotated from the inner wall to the outer wall. At the same time, the first water pipe 801 pulls the corrugated hose 804 to extend the operation, and then the physiological saline is input into the interior of the telescopic water pipe 805 through the water injection pipe at a suitable pressure, and then it is sprayed outward through the nozzle 802 at a suitable pressure, so that the physiological saline is sprayed on the hypertrophic myocardial area, thereby improving the conductivity of the local tissue at the ablation site, improving the consistency and effect of ablation, and at the same time, it can play a cooling role, reduce tissue overheating, reduce tissue temperature, and reduce the risk of thermal damage.

[0055] The above-mentioned front, back, left, right, top and bottom are all based on the figures in the specification. Figure 1 As a benchmark, according to the person's observation perspective, the side of the device facing the observer is defined as the front, the left side of the observer is defined as the left, and so on.

[0056] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the scope of protection of the present invention.

[0057] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A pulsed electric field ablation device for hypertrophic cardiomyopathy, characterized by: The invention comprises a pulse generator (1), a flexible catheter (2) is fixedly mounted on one side of the pulse generator (1), a sliding member (3) is slidably connected to the outer surface of the flexible catheter (2), a fixing member is disposed on the outer surface of the flexible catheter (2), a plurality of PFAD electrode catheters (4) are fixedly mounted in a circular array between the sliding member (3) and the fixing member, a plurality of pulse electrode sheets (5) are disposed on the outer surfaces of the plurality of PFAD electrode catheters (4), an auxiliary ablation component (6) is disposed on the surface of the pulse generator (1) and the flexible catheter (2), a traction control component (7) is disposed on the surface of the flexible catheter (2), and an irrigation component (8) is disposed on the outer surface of the PFAD electrode catheter (4); The auxiliary ablation component (6) comprises an electric field sensor arranged on one side surface of a plurality of pulse electrode sheets (5), a temperature sensor (602) is fixedly mounted on the other side surface of a plurality of pulse electrode sheets (5), a plurality of temperature sensors (602) are fixedly mounted on the outer surface of a PFAD electrode catheter (4), a plurality of first pressure sensors (603) are arranged on the outer surface of a plurality of PFAD electrode catheters (4), and a plurality of reflective marking layers (604) are arranged on the outer surface of a plurality of PFAD electrode catheters (4). A second pressure sensor (605) is provided at one end of the flexible conduit (2), an articulated clamp is provided on the outer surface of the flexible conduit (2), side blocks are fixedly mounted on both sides of the outer surface of the articulated clamp, an optical camera (606) is fixedly mounted on the upper surface of the side block, an annular groove is provided on the outer surface of the flexible conduit (2), an electric slip ring (607) is provided on the inner bottom wall of the annular groove, an electric slider is electrically slidably connected inside the electric slip ring (607), an ultrasonic probe (608) is provided on the upper surface of the electric slider, and the articulated clamps are mutually limit-connected by bolts; The pulse generator (1) has a storage cavity formed inside, the inner side wall of the storage cavity is provided with a mounting plate, a signal processing circuit board (609), a communication circuit board (610) and a power management circuit board (611) are mounted on the surface of the mounting plate, the signal processing circuit board (609), the communication circuit board (610) and the power management circuit board (611) are electrically connected, and the internal components of the auxiliary ablation component (6) are all connected to the power management circuit board (611) via wires; The traction control assembly (7) comprises guide wires (701) arranged on both sides of the inner wall of the flexible conduit (2); guide wheels (702) are slidably connected to both sides of the outer surface of the flexible conduit (2); connecting frames (703) are connected to both sides of the outer surface of the guide wheels (702); connecting rods (704) are rotatably connected to both sides of the outer surface of the connecting frame (703); and a rotating plate (705) is fixedly mounted on the other end of the connecting rod (704); The irrigation assembly (8) comprises a first water pipe (801) arranged on the side surface of a plurality of PFAD electrode catheters (4), a plurality of nozzles (802) being arranged on the surface of the first water pipe (801), a guide ring (803) being fixedly mounted on one end of the first water pipe (801), the guide ring (803) being rotatably connected to the outer surface of the PFAD electrode catheter (4), a corrugated hose (804) being fixedly mounted on one end of the first water pipe (801), a telescopic water pipe (805) being fixedly mounted on one end of a plurality of the corrugated hoses (804), a water injection pipe being arranged on one end of the telescopic water pipe (805), and the water injection pipe being arranged on the outer surface of the flexible catheter (2); The auxiliary ablation component (6) further comprises a storage box arranged on the side surface of the pulse generator (1), the inner side wall of the storage box being connected to a telescopic frame (613), one end of the telescopic frame (613) being rotatably connected to a magnetic field generator (614), and the surface of the storage box being rotatably connected to a protective cover.

2. The pulsed electric field ablation device for hypertrophic cardiomyopathy according to claim 1, characterized in that: The signal processing circuit board (609) includes a high-speed analog-to-digital converter arranged on the surface of the mounting board. The high-speed analog-to-digital converter is internally provided with artificial intelligence and machine learning algorithms. The high-speed analog-to-digital converter is used to convert analog signals into digital signals, and digitally process, reconstruct and enhance the signals of the ultrasound probe (608) to improve the quality and resolution of the image. A digital signal processor and a memory are arranged on one side of the high-speed analog-to-digital converter. The digital signal processor and the memory are used to decode and calculate the coordinates of the signals of the second pressure sensor (605) and the first pressure sensor (603), and determine the accurate positions of the pulse electrode sheet (5) and the PFAD electrode catheter (4) in the heart.

3. The pulsed electric field ablation device for hypertrophic cardiomyopathy according to claim 2, characterized in that: The communication circuit board (610) includes a communication interface chip and a protocol stack chip arranged on the surface of the mounting plate. A display (615) is arranged on the upper surface of the pulse generator (1). The display (615) is electrically connected to the communication circuit board (610). The communication interface chip and the protocol stack chip convert the signal processed by the signal processing circuit board (609) into the display (615), so that the doctor can observe the operation in real time. One side of the communication interface chip is electrically connected to a cable interface (612) through a wire. The cable interface (612) is fixedly installed on the side surface of the pulse generator (1).

4. The pulsed electric field ablation device for hypertrophic cardiomyopathy according to claim 1, characterized in that: A clamping column is fixedly mounted on one side surface of the rotating plate (705), one end of the clamping column is rotatably connected to a clamping cylinder, the clamping cylinder is fixedly mounted on the outer surface of the flexible conduit (2), the outer surface of the flexible conduit (2) is provided with a fixed clamping ring (706), a clamping plate is fixedly mounted on the lower surface of the fixed clamping ring (706), and the interior of the clamping plate is rotatably connected to a rotating shaft (707).

5. The pulsed electric field ablation device for hypertrophic cardiomyopathy according to claim 4, characterized in that: Damping plates (708) are fixedly mounted on both side surfaces of the rotating shaft (707), the damping plates (708) being closely attached to the side surfaces of the clamping plate, transmission wheels are fixedly mounted on the outer surfaces of the rotating shaft (707) and the clamping column, a transmission belt is overlapped on the outer surface of the transmission wheel, and a rotating handle is fixedly mounted on one end of the rotating shaft (707).

6. The pulsed electric field ablation device for hypertrophic cardiomyopathy according to claim 5, characterized in that: The lower surface of the sliding member (3) is rotatably connected to a plurality of driven gears (806) and a driving gear ring (807); a first water pipe (801) is fixedly mounted on the lower surface of the driven gear (806); one side of the plurality of driven gears (806) is meshingly connected to the driving gear ring (807); an electromagnetic coil (808) is disposed inside the sliding member (3); the electromagnetic coil (808) is electrically connected to a power management circuit board (611) via a wire; and a rotor is disposed on the inner side wall of the driving gear ring (807).

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