Automatic temperature calibration system and method

Abstract

The invention belongs to the technical field of blood purification, and relates to an automatic temperature calibration system and method.The automatic temperature calibration system comprises liquid purification equipment and a calibration device which are detachably connected, the liquid purification equipment comprises a heating piece and a first temperature sensor which are connected with a control device, and the heating piece is used for heating liquid in a heating cavity; the first temperature sensor is used for collecting a current first temperature signal of liquid on the inlet side and / or the outlet side of the heating cavity and feeding back the first temperature signal to the control device. The calibration device comprises a constant-temperature liquid circulating device used for simulating a target object, a second temperature sensor used for collecting an actual second temperature signal of the heated liquid on the outlet side of the heating cavity, and a temperature inspection instrument used for transmitting the second temperature signal to the control device; according to the invention, heating devices of different liquid purification equipment can be conveniently detected, the calibration points can be automatically switched according to the preset flow velocity from small to large for temperature calibration, the calibration is accurate and efficient, the operation is simple, and the cost is low.

Description

Technical Field

[0001] The present application relates to the technical field of blood purification, and in particular to a temperature automatic calibration system and method. Background Art

[0002] Blood purification equipment is a medical device that removes certain specific substances such as waste, toxins, and excess fluid from the blood after it is drawn out of the body, and then returns the purified blood to the body to maintain the internal environment balance such as electrolyte balance and acid-base balance in the body, so as to purify the blood and treat diseases. Because the blood needs to be filtered through a filter device, the heat loss of the air, and the low temperature of the infusion fluid, the temperature of the blood outside the body will inevitably drop. Therefore, a heating device is usually installed in the blood purification equipment to heat the purified blood returned to the patient, so as to maintain the patient's normal body temperature as much as possible, promote the patient's recovery, and avoid the patient from being in danger due to hypothermia.

[0003] In practice, the inventors found that due to the inherent errors of the heating device and the built-in temperature sensor of the heating device, it is difficult for the blood purification device to accurately heat the returned blood to the normal body temperature of the patient, such as 37°C, before it is used or after a period of use. Therefore, before it is put into daily use, the heating temperature of the heating device in the blood purification device needs to be calibrated so that the temperature of the returned blood can reach an appropriate temperature to ensure the heating effect.

[0004] However, in the prior art, either the heating temperature is calibrated manually, which requires the calibrator to manually input the actual temperature measurement value and monitor the calibration process throughout, which is time-consuming and labor-intensive, or an expensive temperature detection device is used for temperature control. But in general, no matter which method is used, the calibration operation is relatively complicated and inefficient, and it is still difficult to ensure that the calibration result reaches and stably maintains the desired temperature value. Summary of the invention

[0005] The present application aims to solve at least one of the above-mentioned technical problems existing in the prior art.

[0006] In a first aspect, an embodiment of the present application provides a temperature automatic calibration system, which adopts the following technical solution:

[0007] The automatic temperature calibration system comprises a liquid purification device and a calibration device, wherein the calibration device is detachably connected to the liquid purification device and is used to assist the liquid purification device in automatically calibrating the heating temperature of the purified liquid;

[0008] The liquid purification equipment comprises:

[0009] Control devices;

[0010] A liquid purifier, connected to the target object through a first pipeline, and used to purify the liquid output by the target object;

[0011] a driving pump, disposed in the first pipeline, electrically connected to the control device, and used to provide driving force for the target object to input the liquid into the liquid purifier; and

[0012] The heating device comprises a body, wherein a heating chamber is formed in the body, and an inlet and an outlet communicated with the heating chamber are provided, wherein the inlet is used for inputting the liquid purified by the liquid purifier into the heating chamber; and the outlet is used for outputting the liquid in the heating chamber to be returned to the target object through a second pipeline;

[0013] The heating device also includes:

[0014] a heating element, disposed on the body and electrically connected to the control device, and used for heating the liquid in the heating chamber under the control of the control device; and

[0015] a first temperature sensor, electrically connected to the control device, for collecting a current first temperature signal of the liquid at the inlet side and / or the outlet side of the heating chamber, and feeding the first temperature signal back to the control device;

[0016] Wherein, the calibration device comprises:

[0017] A constant temperature liquid circulation device, which serves as the target object during temperature calibration and can circulate liquid inside to maintain the target temperature; the constant temperature liquid circulation device is detachably connected to the driving pump through the first pipeline, and is detachably connected to the heating device through the second pipeline;

[0018] A second temperature sensor is used to collect a second temperature signal of the liquid actually heated at the outlet side of the heating chamber;

[0019] A temperature patrol meter is electrically connected to the second temperature sensor and the control device, and is used to transmit the second temperature signal to the control device so that the control device controls the liquid purification equipment to calibrate the first temperature signal according to the second temperature signal.

[0020] In some embodiments of the present application, the second temperature sensor is installed in the second pipeline, and the second temperature sensor includes a temperature measuring part, which is used to collect the actual second temperature signal of the heated liquid returned to the constant temperature liquid circulation device through the second pipeline.

[0021] In some embodiments of the present application, a temperature measuring hole is provided in the second pipeline at the outlet side of the heating device; the temperature measuring part is closedly inserted into the temperature measuring hole to collect a second temperature signal of the heated liquid in the second pipeline;

[0022] Alternatively, the calibration device further comprises:

[0023] A three-way connector has a first interface, a second interface and a third interface that are interconnected; the first interface is connected to the outlet of the heating device through a joint and a section of the second pipeline in sequence, the second interface is connected to the constant temperature liquid circulation device through another section of the second pipeline, and the third interface is plugged with the temperature measuring part.

[0024] In some embodiments of the present application, the distance between the location of the temperature measuring part and the outlet of the heating device is 1 cm to 2 cm;

[0025] And / or, the second temperature sensor further comprises a connecting wire, one end of which is connected to the temperature measuring part, and the other end of which is connected to the temperature inspection instrument;

[0026] The calibration device also includes:

[0027] The installation tube has a first end and a second end that are connected to each other; the first end of the installation tube is connected to the third interface, and the second end is for the temperature measuring part to pass through and extend to the third interface and for part of the connecting line to extend into.

[0028] In some embodiments of the present application, the calibration device further includes a positioning clamp, which is used to clamp the connecting wire in the installation tube to assist in positioning the temperature measuring part at a target position;

[0029] And / or, the calibration device further comprises a packaging tube, one end of which is connected to the second end of the mounting tube, and the other end of which is used for the connecting wire in the mounting tube to pass through and is packaged with a seal.

[0030] In some embodiments of the present application, the temperature patrol meter is a multi-channel temperature patrol meter, which is used to simultaneously connect multiple liquid purification devices;

[0031] Wherein, the temperature patrol meter is connected to the control device of each of the liquid purification devices via a signal transmission line, so as to transmit the second temperature signal collected by the corresponding second temperature sensor to the control device;

[0032] And / or, the liquid purification device is a blood purification device.

[0033] On the second aspect, in order to solve the above-mentioned technical problem, the embodiment of the present application further provides a temperature calibration device, which adopts the following technical solution: the temperature calibration device adopts the calibration device of the above-mentioned automatic temperature calibration system.

[0034] In the third aspect, in order to solve the above technical problems, the embodiment of the present application also provides a method for automatic temperature calibration, which adopts the following technical solution:

[0035] In the temperature automatic calibration method, N calibration points are provided, where N is a positive integer greater than or equal to 3; the predetermined flow rates corresponding to the N calibration points gradually increase, wherein the predetermined flow rate corresponding to the first current calibration point is the minimum predetermined flow rate; and the predetermined flow rate corresponding to the Nth current calibration point is the maximum predetermined flow rate;

[0036] The automatic temperature calibration method uses a calibration device to automatically calibrate the liquid returned from the liquid purification device, in sequence, at the predetermined flow rate corresponding to the N calibration points, and at the heating temperature of each calibration point;

[0037] The automatic temperature calibration method comprises:

[0038] Step S1: Calibration start step

[0039] Connect the constant temperature liquid circulation device of the calibration device to the heating device and the liquid purifier of the liquid purification device to form a circulating liquid circuit; start the calibration device and the liquid purification device, and heat the liquid in the constant temperature liquid circulation device to a standard temperature value T0 and then keep it warm;

[0040] Step S2: Heating step according to the current target heating temperature value T1 at the current calibration point

[0041] The driving pump of the liquid purification device operates at the predetermined flow rate of the current calibration point, and the heating device heats the liquid purified by the liquid purifier according to the current target heating temperature value T1; wherein the initial flow rate of the current calibration point is the minimum predetermined flow rate; the initial current target heating temperature value of each current calibration point is the default machine target heating temperature value of the device;

[0042] Step S3: Obtaining the actual heating temperature value

[0043] The second temperature sensor of the calibration device obtains the actual heating temperature value T2 of the return liquid at the outlet side of the heating device, and transmits the actual heating temperature to the control device of the liquid purification equipment;

[0044] Step S4: Compare the actual heating temperature value T2 with the standard temperature value T0

[0045] If the actual heating temperature value T2 is not within the preset temperature range, the calibration target heating temperature value T1' is obtained according to the preset calibration formula, and the current target heating temperature value T1 is updated to the calibration target heating temperature value T1', and the predetermined flow rate of the current calibration point is used to repeat the steps S2 to S4 in sequence until the actual heating temperature value T2 is within the preset temperature range;

[0046] If the actual heating temperature value T2 is within the preset temperature range, further determining whether the actual heating temperature value T2 reaches the preset temperature range for the first time;

[0047] If yes, then stop heating and wait for the temperature to drop, and then execute the steps S2 to S4 in sequence until the actual heating temperature value T2 is within the preset temperature range for the second time;

[0048] If not, the actual heating temperature value T2 has reached the preset temperature range twice, then the calibration of the current calibration point is qualified, the current target heating temperature value in step S2 is saved as the final target heating temperature value of the current calibration point, the calibration of the current calibration point is completed, the current calibration point is switched to the next calibration point, and then the steps S2 to S4 are sequentially executed until the calibration of the Nth calibration point is completed;

[0049] Step S5: After the N calibration points are calibrated in sequence, the liquid purification equipment and the calibration device automatically stop.

[0050] In some embodiments of the present application, in step S3, the step of obtaining the actual heating temperature value T2 of the reinfused liquid specifically includes:

[0051] The second temperature sensor detects the liquid temperature at the outlet of the heating device in real time, and when the error of the liquid temperature at the outlet is detected to be within a first preset time length and within a preset error range, the second temperature sensor outputs the liquid temperature as the actual heating temperature value T2;

[0052] And / or, in step S4, the step of stopping heating and waiting for cooling specifically includes:

[0053] The heating device stops heating under the control of the control device;

[0054] The driving pump operates at the maximum predetermined flow rate for a second preset time period to cool the liquid outside the constant temperature liquid circulation device.

[0055] In some embodiments of the present application, the liquid purification device is a blood purification device;

[0056] And / or, the calibration formula in step S4 is as follows:

[0057] Calibration target heating temperature value T1' = calibration coefficient K * current target heating temperature value T1

[0058] Wherein, calibration coefficient K = standard temperature value T0 / actual heating temperature value T2;

[0059] And / or, the standard temperature value T0 is 37°C;

[0060] And / or, there are 5 calibration points, and the predetermined flow rates corresponding to the 5 calibration points are 15 ml / min, 80 ml / min, 160 ml / min, 200 ml / min, and 400 ml / min, respectively, wherein the minimum predetermined flow rate is 15 ml / min, and the maximum predetermined flow rate is 400 ml / min;

[0061] And / or, the preset temperature range is 36.8°C to 37.2°C.

[0062] Compared with the prior art, the temperature automatic calibration system and method provided in the embodiment of the present application mainly have the following beneficial effects:

[0063] The temperature automatic calibration system is composed of a constant temperature liquid circulation device, a second temperature sensor, a temperature patrol meter, etc. to form an independent and complete calibration device, and the calibration device is detachably connected to the liquid purifier and heating device of the liquid purification equipment such as the blood purification equipment. It can not only facilitate the detection of the heating devices of different liquid purification equipment, but also can realize the automatic calibration of the heating temperature of the heating device of the liquid purification equipment under the control of the control device through the cooperation of the first temperature sensor, the second temperature sensor, the temperature patrol meter, the heating element, the driving pump, etc., and can automatically switch the calibration points of different flow rates for temperature calibration. The temperature automatic calibration method can automatically switch the calibration points of different flow rates for temperature calibration, and automatically switch the calibration points according to the predetermined flow rate from small to large. In general, the present application makes full use of the existing structure and procedures of the liquid purification equipment on the basis of not changing or changing the liquid purification equipment as little as possible, and realizes the automatic temperature calibration through the cooperation of the calibration device and the liquid purification equipment. The calibration operation is simple and reliable, which is conducive to improving the calibration efficiency and saving labor costs. At the same time, it is also conducive to reducing the calibration error and shortening the delivery time of the liquid purification equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0064] In order to more clearly illustrate the scheme in this application, the following is a brief introduction to the drawings required for the description of the embodiments. Obviously, the drawings described below are some embodiments of this application or corresponding prior art. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work. Among them:

[0065] Figure 1This is a structural connection block diagram of a temperature automatic calibration system in an example of the present application;

[0066] Figure 2 This is a basic structural diagram of a blood purification device in an example of the present application;

[0067] Figure 3 This is a connection diagram of an automatic temperature calibration system in an example of the present application when it is working;

[0068] Figure 4 This is another connection diagram when the automatic temperature calibration system in an example of the present application is working;

[0069] Figure 5 It is a schematic diagram of a three-dimensional structure in which a second temperature sensor in an automatic temperature calibration system in an example of the present application is connected to a heating device through a three-way connector;

[0070] Figure 6 is a schematic diagram of the three-dimensional structure of a second temperature sensor in a calibration device in an example of the present application;

[0071] Figure 7 This is a structural connection block diagram of a multi-channel temperature inspection instrument in a temperature automatic calibration system in an example of the present application, which can calibrate multiple liquid purification devices at the same time;

[0072] Figure 8 is a flow chart of calibrating all calibration points in a temperature automatic calibration method in an example of the present application;

[0073] Fig. 9 This is a flow chart of calibrating a single calibration point in an automatic temperature calibration method in an example of the present application, wherein in the figure, the predetermined flow rate of the single calibration point is 15 ml / min.

[0074] The reference numerals in the accompanying drawings are as follows:

[0075] 1000. Automatic temperature calibration system;

[0076] 100, liquid purification device / blood purification device; 110, first pipeline; 120, driving pump; 130, liquid purifier; 140, heating device; 141, body; 1411, heating chamber; 1412, inlet; 1413, outlet; 142, heating element; 143, first temperature sensor; 150, control device; 160, display; 170, memory; 180, liquid level detector; 190, second pipeline;

[0077] 200, calibration device; 210, constant temperature liquid circulation device; 220, second temperature sensor; 221, temperature measuring part / temperature measuring probe; 222, connecting line; 230, temperature patrol meter; 240, three-way connector; 241, first interface; 242, second interface; 243, third interface; 250, joint; 260, installation tube; 261, first end; 262, second end; 270, positioning clamp; 280, packaging tube. DETAILED DESCRIPTION

[0078] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field of this application; the terms used in this specification are only for the purpose of describing specific embodiments and are not intended to limit the present application. For example, the directions or positions indicated by the terms "length", "width", "up", "down", "left", "right", "front", "back", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc. are based on the directions or positions shown in the drawings, which are only for the convenience of description and cannot be understood as limitations on the present technical solution.

[0079] The terms "including" and "having" and any variations thereof in the specification and claims of this application and the above-mentioned drawings are intended to cover non-exclusive inclusions; the terms "first", "second", etc. in the specification and claims of this application or the above-mentioned drawings are used to distinguish different objects rather than to describe a specific order. "Multiple" means two or more, unless otherwise clearly and specifically limited.

[0080] In the specification and claims of this application and the above-mentioned drawings, when an element is referred to as being "fixed to" or "mounted on" or "disposed on" or "connected to" another element, it may be directly or indirectly located on the other element. For example, when an element is referred to as being "connected to" another element, it may be directly or indirectly connected to the other element.

[0081] In addition, reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0082] The embodiment of the present application provides a temperature automatic calibration system 1000, which can be applied to a liquid purification device 100 to realize automatic calibration of the heating temperature of the liquid purification device 100. The liquid purification device 100 described herein includes but is not limited to a blood purification device 100. The liquid circulating in the liquid purification device 100 may be blood or other liquids, such as water. For the convenience of description, the following mainly takes the liquid purification device 100 as a blood purification device 100 as an example for description.

[0083] like Figure 1 , Figure 3 and Figure 4 As shown, the automatic temperature calibration system 1000 includes a calibration device 200 and a liquid purification device 100. The calibration device 200 is detachably connected to the liquid purification device 100. The calibration device 200 is mainly used to assist the liquid purification device 100 in automatically calibrating the heating temperature of the purified liquid.

[0084] Taking the blood purification equipment 100 as an example, through the detachable connection between the calibration device 200 and the liquid purification equipment 100, the calibration device 200 can be reused as a whole, which makes it convenient to use the same calibration device 200 to calibrate the heating temperature of the liquid of the heating devices 140 (specifically, a heating bag) of different blood purification equipment 100 in turn. It is easy to disassemble and replace, which is conducive to reducing the cost of temperature calibration.

[0085] In the embodiments of the present application, Figure 1 As shown, the liquid purification device 100 includes a control device 150, a liquid purifier 130, a drive pump 120 and a heating device 140. Exemplarily, taking the blood purification device 100 as an example, the blood purification device 100 can apply different types of blood treatment modes, such as a blood perfusion treatment mode, a hemodialysis treatment mode, etc. In different blood treatment modes, the type of blood purifier will also be different, for example, it can be a blood perfusion device, a dialyzer, etc. or a combination thereof, so there are correspondingly multiple ways of connecting the pipes in the blood purification device 100. But in general, the basic structures of different types of blood purification devices 100 are basically the same (see Figure 2 ), the details are as follows:

[0086] like Figure 2 and Figure 3As shown, the liquid purifier 130 is connected to the target object through the first pipeline 110, and is used to purify the liquid output by the target object. It should be noted that the target object in this article can be a human body, other organisms, or other suitable non-biological bodies, and is not particularly limited here. It only needs that the liquid in the target object can maintain a constant temperature inside the target object, and after connecting to the liquid purification device 100, the internal liquid can be transported to the liquid purification device 100 for liquid purification, and the purified liquid is then returned to the target object.

[0087] The driving pump 120 is provided in the first pipeline 110 and is electrically connected to the control device 150, wherein the driving pump 120 can be used to provide driving force for the liquid of the target object to be input into the liquid purifier 130. Understandably, the driving pump 120 is located between the target object and the liquid purifier 130. Under the control of the control device 150, the driving pump 120 enables the liquid outputted by the target object through the first pipeline 110 to be input into the liquid purifier 130 at different flow rates, so as to provide different flow rates according to different needs of the patient, improve the comfort of the patient, and facilitate the automatic calibration of the temperature automatic calibration system 1000 to automatically calibrate different calibration points.

[0088] For example Figure 3 and Figure 5 As shown, the heating device 140 includes a body 141, and a heating chamber 1411, an inlet 1412 and an outlet 1413 are formed in the body 141, wherein the inlet 1412 and the outlet 1413 are both connected to the heating chamber 1411, and the inlet 1412 can be used to input the liquid purified by the liquid purifier 130 into the heating chamber 1411; the outlet 1413 can be used to output the liquid in the heating chamber 1411, so as to be returned to the target object through the second pipeline 190. It should be noted that in the liquid purification device 100, the outlet 1413 and the target object are not limited to only the second pipeline 190, and other suitable components can also be provided.

[0089] Exemplarily, in the blood purification device 100, the first pipeline 110 is usually an arterial pipeline, one end of the first pipeline 110 can be connected to the human artery, and the other end can be connected to the blood input end of the blood purifier, and the driving pump 120 (which can be a blood pump, specifically a peristaltic pump) is arranged in the middle part of the first pipeline 110; the second pipeline 190 is usually a venous pipeline, one end of the second pipeline 190 can be connected to the blood output end of the blood purifier, and the other end can be connected to the human vein. Among them, the second pipeline 190 can be connected by multiple sections of pipelines, so that other functional parts can be connected in the middle.

[0090] like Figure 1As shown, the heating device 140 further includes a heating element 142 and a first temperature sensor 143. The heating element 142 is disposed on the body 141 and is electrically connected to the control device 150; the first temperature sensor 143 is electrically connected to the control device 150. The heating element 142 can be used to heat the liquid in the heating chamber 1411 under the control of the control device 150. For example, the control device 150 can adjust the heating temperature of the heating element 142 by pulse width modulation PWM to increase or decrease the temperature, so that the liquid in the heating chamber 1411 reaches the target heating temperature. For example, the body 141 of the heating device 140 can be a bag body, that is, the heating device 140 can be a heating bag, wherein the interior of the heating bag can be a tubular structure in a coiled, reciprocating zigzag, etc. The heating element 142 can be attached to the outer wall of the heating bag to heat the heating bag, and the heating bag is heated by heating by powering on, so that the liquid flowing in the heating bag can be heated.

[0091] In addition, the first temperature sensor 143 is used to collect the current first temperature signal of the liquid at the inlet and / or outlet side of the heating chamber 1411, and feed the first temperature signal back to the control device 150. It should be noted that the first temperature value T1 corresponding to the first temperature signal described herein has an initial value that is the machine temperature value of the program default in the liquid purification device 100. The initial first temperature values ​​of the following different calibration points may be the same or different. Due to the manufacturing error of the equipment, the automatic temperature calibration system 1000 mainly calibrates the initial first temperature value corresponding to each calibration point to ensure that the temperature of the liquid returned to the target object is within the preset temperature range.

[0092] It should also be noted that if Figure 1 As shown, the liquid purification device 100 may also generally include a memory 170, a display 160 and a liquid level detector 180, wherein the memory 170, the display 160 and the liquid level detector 180 are all connected to the control device 150, wherein the memory 170 may be used to store computer programs and various data, the control device 150 may be used to execute computer programs, and the display 160 may realize interactive communication under the control of the control device 150, for example, the user may directly operate and click "start" on the display 160, so as to directly instruct each component to start running after the temperature automatic calibration system 1000 is connected, so as to complete the automatic calibration of the temperature. In addition, the liquid level detector 180 is used to detect the liquid level of the liquid in the liquid flow circuit, and feed the data back to the control device 150, when the liquid level is too high, the control device 150 may control the drive pump 120 to reduce the flow rate to reduce the liquid in the venous line.

[0093] In the embodiments of the present application, Figure 1 , Figure 3 and Figure 4As shown, the calibration device 200 includes a constant temperature liquid circulation device 210, a second temperature sensor 220 and a temperature inspection meter 230, wherein the constant temperature liquid circulation device 210 is detachably connected to the driving pump 120 of the liquid purification device 100 through the first pipeline 110, and is detachably connected to the heating device 140 of the liquid purification device 100 through the second pipeline 190. During temperature calibration, the constant temperature liquid circulation device 210 can simulate the target object of the liquid purification device 100 during daily operation, and can circulate the liquid internally while maintaining the target temperature T0.

[0094] Exemplarily, the constant temperature liquid circulation device 210 may be a constant temperature water tank, wherein the constant temperature water tank may be used to simulate the blood system of the human body, and the constant temperature water tank may be connected to the first pipeline 110 (corresponding to the arterial pipeline) and the second pipeline 190 (corresponding to the venous pipeline) respectively, and during the automatic temperature calibration process, the constant temperature water tank may transport water reaching the human body temperature of 37° C. to the blood purifier, and the internal water temperature is maintained at 37° C. In this way, water may be used to simulate blood circulation through the blood purifier, the heating device 140 and the human body's blood circulation system under the drive of the blood pump.

[0095] Understandably, when the calibration device 200 assists the blood purification device 100 in performing heating temperature calibration, the circulating liquid used by the temperature automatic calibration system 1000 can be the blood used in the daily operation of the blood purification device 100, or other types of liquids such as water. Specifically in this embodiment, the constant temperature liquid circulation device 210 is directly used as the target object to simulate the human body, which is beneficial to saving resources and simplifying the calibration operation.

[0096] In addition, the second temperature sensor 220 can be used to collect the actual second temperature signal of the liquid after heating at the outlet side of the heating chamber 1411. It should be noted that the second temperature value T2 corresponding to the second temperature signal described herein is the actual temperature value of the returned liquid after heating. It is understandable that if the actual temperature value is significantly different from the target temperature T0 of the constant temperature liquid circulation device 210 and is not within the preset temperature range, the first temperature value T1 corresponding to the first temperature signal needs to be calibrated.

[0097] For example Figure 1 As shown, the temperature patrol meter 230 is electrically connected to the second temperature sensor 220 and the control device 150, and is used to transmit the second temperature signal to the control device 150, so that the control device 150 controls the liquid purification equipment 100 to calibrate the first temperature signal according to the second temperature signal.

[0098] It can be understood that the working principle of the temperature automatic calibration system 1000 is as follows: the temperature automatic calibration system 1000 simulates the human blood system by using the constant temperature liquid circulation device 210. Before the liquid purification device 100 leaves the factory or is used daily, the constant temperature liquid circulation device 210 can be detachably connected to the liquid purifier 130 and the heating device 140, so as to cooperate with the liquid purification device 100 to form the temperature automatic calibration system 1000; after startup, the first temperature sensor 143 of the heating device 140 can collect the first temperature value T1 obtained by heating the liquid by the machine temperature value defaulted by the application, and feed the first temperature value T1 back to the control device 150;

[0099] In addition, the second temperature sensor 220 of the calibration device 200 can directly collect the actual second temperature value T2 of the liquid after being heated by the heating element 142 at the outlet side of the heating chamber 1411, and feed back the second temperature value T2 to the control device 150 through the temperature patrol meter 230. The control device 150 compares T2 with the target temperature T0 of the constant temperature liquid circulation device 210. If T2 is within the error temperature range of T0, there is no need to calibrate the first temperature value T1. If T2 is not within the error temperature range of T0, it is necessary to calibrate the first temperature value T1 until T2 is within the error temperature range of T0, and update the original first temperature value T1 to the latest first temperature value T1'. In this way, in daily use in the future, the heating element 142 is controlled to heat with the latest first temperature value T1', thereby ensuring that the temperature of the liquid returned to the target object can meet the temperature expected by the user; in addition, the control device 150 controls the drive pump 120 to make the liquid run at different flow rates, so as to automatically calibrate the heating temperature of the liquid at different flow rates.

[0100] In summary, compared with the prior art, the temperature automatic calibration system 1000 has at least the following beneficial effects:

[0101] The temperature automatic calibration system 1000 is composed of a constant temperature liquid circulation device 210, a second temperature sensor 220, a temperature patrol meter 230, etc., which form an independent and complete calibration device 200, and the calibration device 200 is detachably connected to the liquid purifier 130 and the heating device 140 of the liquid purification device 100, which can not only facilitate the detection of the heating device 140 of different liquid purification devices 100, but also can be controlled by the first temperature sensor 143, the second temperature sensor 220, the temperature patrol meter 230, the heating element 142, the driving pump 140, etc. 20, etc., the heating temperature of the heating device 140 of the liquid purification equipment 100 can be automatically calibrated, and the calibration points of different flow rates can be automatically switched for temperature calibration, so that the existing structure and procedures of the liquid purification equipment 100 can be fully utilized without changing or changing the liquid purification equipment 100 as little as possible. Through the cooperation of the calibration device 200 and the liquid purification equipment 100, automatic temperature calibration can be achieved. The calibration operation is simple and reliable, which is beneficial to improving the calibration efficiency and saving labor costs. At the same time, it is also beneficial to reduce the calibration error and shorten the delivery time of the liquid purification equipment 100.

[0102] In order to make the technical personnel in this field better understand the present application scheme, the following will be combined with the attached Figures 1 to 7 , clearly and completely describe the technical solutions in the embodiments of the present application.

[0103] In some embodiments of the present application, Figure 1 and Figure 3 As shown, at the outlet side of the heating chamber 1411 of the heating device 140, a second temperature sensor 220 is installed on the second pipeline 190, and the second temperature sensor 220 includes a temperature measuring part 221, wherein the temperature measuring part 221 can be used to collect the actual second temperature signal of the heated liquid that is returned to the constant temperature liquid circulation device 210 through the second pipeline 190.

[0104] Optionally, the temperature measuring part 221 is a temperature sensing probe; the second temperature sensor 220 can be optionally a thermistor temperature sensor, which also includes a connecting line 222, wherein one end of the connecting line 222 is connected to the temperature sensing probe, and the other end is connected to the temperature patrol meter 230. The second temperature signal collected by the temperature sensing probe can be transmitted to the temperature patrol meter 230 via the connecting line 222.

[0105] It can be understood that by installing a second temperature sensor 220 on the outlet side of the heating chamber 1411 of the heating device 140, the water temperature measured by the second temperature sensor 220 can be closer to the constant temperature liquid circulation device 210 (corresponding to the human body end), so that the temperature of the heated reinfused blood under actual use conditions can be more realistically simulated.

[0106] In order to install the second temperature sensor 220 on the second pipeline 190 at the outlet side of the heating device 140, there are at least two specific implementations as follows:

[0107] In the first specific embodiment, a temperature measuring hole (not shown) is provided in the second pipeline 190 at the outlet side of the heating device 140; the temperature measuring part 221 is closed and inserted into the temperature measuring hole to collect the second temperature signal of the heated liquid in the second pipeline 190. Exemplarily, a temperature measuring hole is provided in the axial direction of the second pipeline 190, and the temperature sensing probe of the second temperature sensor 220 is inserted into the temperature measuring hole to detect the temperature of the heated liquid in the second pipeline 190. It should be noted that the temperature sensing probe can directly block the temperature measuring hole to avoid water leakage; in addition, the size of the temperature sensing probe should not be too large to reduce the influence of the temperature sensing probe on the liquid flow rate, so as to reduce the influence of the flow rate of the heated liquid in the second pipeline 190 on the temperature detection result.

[0108] Alternatively, in a second specific embodiment, Figure 1 and Figure 5 As shown, the calibration device 200 also includes a three-way connector 240, which has a first interface 241, a second interface 242 and a third interface 243 that are interconnected (see Figure 5 ), wherein the first interface 241 is connected to the outlet 1413 of the heating device 140 through the joint 250 and a section of the second pipeline 190 in sequence, the second interface 242 is connected to the constant temperature liquid circulation device 210 through another section of the second pipeline 190, and the third interface 243 is plugged with a temperature measuring part 221. It can be understood that the temperature measuring part 221 of the second temperature sensor 220 does not enter the second pipeline 190, but directly detects the temperature of the heated liquid in the second pipeline 190 at the third interface 243 that communicates with the second pipeline 190. On the one hand, it can avoid extending the temperature measuring part 221 into the second pipeline 190, reducing the influence of the temperature measuring part 221 on the liquid flow rate in the loop, and on the other hand, it can avoid directly opening a hole in the second pipeline 190, avoiding the influence of atmospheric circulation on the liquid flow rate in the second pipeline 190, thereby facilitating to minimize the influence of the temperature measuring installation structure of the second temperature sensor 220 on the liquid flow rate, and facilitating accurate calibration of calibration points with different flow rates.

[0109] In some embodiments of the present application, the distance between the temperature measuring portion 221 of the second temperature sensor 220 and the outlet 1413 of the heating device 140 is 1 cm to 2 cm, so that the temperature of the heated reinfusion liquid measured by the second temperature sensor 220 is closer to the actual usage state.

[0110] and / or, if Figure 5 and Figure 6As shown, the second temperature sensor 220 also includes a connecting line 222, wherein one end of the connecting line 222 is connected to the temperature measuring part 221, and the other end is connected to the temperature patrol meter 230, so that the second temperature signal collected by the temperature measuring part 221 can be transmitted to the temperature patrol meter 230 through the connecting line 222.

[0111] For example Figure 5 As shown, to ensure the installation stability of the second temperature sensor 220, the calibration device 200 further includes a mounting tube 260, and the mounting tube 260 has a first end 261 and a second end 262 that are in communication, wherein the first end 261 of the mounting tube 260 is connected to the third interface 243 of the three-way connector 240, and the second end 262 of the mounting tube 260 is for the temperature measuring portion 221 of the second temperature sensor 220 to pass through and extend to the third interface 243 and for part of the connecting wire 222 to extend into. It can be understood that the temperature measuring portion 221 of the second temperature sensor 220 and the connecting wire 222 connected thereto can extend into the mounting tube 260 from the second end 262 of the mounting tube 260. In order to measure the temperature of the heated liquid, the temperature measuring portion 221 will pass through the mounting tube 260 and enter the third interface 243, and one end of the connecting wire 222 close to the temperature patrol meter 230 is exposed in the mounting tube 260 and can be connected to the temperature patrol meter 230.

[0112] Optionally, in order to further ensure the installation stability of the second temperature sensor 220 and to ensure the accuracy and safety of temperature detection, the calibration device 200 further includes a positioning clamp 270, wherein the positioning clamp 270 can be used to clamp the connecting wire 222 in the installation tube 260 to assist in positioning the temperature measuring part 221 at the target position. Exemplarily, the installation tube 260 is a hose, and the connecting wire 222 in the installation tube 260 is clamped by the positioning clamp 270 to prevent the connecting wire 222 from moving and further extending into or out of the installation tube 260, thereby fixing the temperature measuring part 221 of the second temperature sensor 220 at the detection position of the third interface 243 of the three-way connector 240, ensuring accurate detection of the water temperature at the outlet 1413 of the heating device 140.

[0113] And / or, optionally, in order to further improve the installation stability and safety of the second temperature sensor 220, the calibration device 200 also includes a packaging tube 280, wherein one end of the packaging tube 280 (specifically, the head end) is connected to the second end 262 of the mounting tube 260, and the other end of the packaging tube 280 (specifically, the tail end) is for the connecting wire 222 in the mounting tube 260 to pass through and is encapsulated with a seal.

[0114] Exemplarily, the packaging tube 280 is a hard tube, and the end of the connecting line 222 close to the temperature inspection meter 230 passes through the mounting tube 260 and the packaging tube 280 in sequence to connect with the temperature inspection meter 230. Among them, the opening at the tail end of the packaging tube 280 is larger than the opening at the head end, so that it is convenient to inject glass glue into the tail end of the packaging tube 280 to ensure that the entire liquid flow circuit is sealed, effectively reducing the probability of water leakage.

[0115] In some embodiments of the present application, Figure 7 As shown, the temperature patrol meter 230 is a multi-channel temperature patrol meter 230, which can be used to connect multiple liquid purification devices 100 at the same time.

[0116] Among them, the temperature patrol meter 230 is connected to the control device 150 of each liquid purification device 100 through a signal transmission line to transmit the second temperature signal collected by the corresponding second temperature sensor 220 to the control device 150. It can be understood that multiple calibration devices 200 can share a multi-channel temperature patrol meter 230. Specifically, the second temperature sensor 220 of each calibration device 200 is connected to the same multi-channel temperature patrol meter 230 through a corresponding connection line 222; and multiple liquid purification devices 100 also share a multi-channel temperature patrol meter 230. Specifically, the control device 150 of each liquid purification device 100 is connected to the same multi-channel patrol meter through a corresponding signal transmission line, so as to improve the calibration efficiency, save calibration time, and shorten the delivery time of the liquid purification device 100.

[0117] For example, the temperature patrol meter 230 may be a temperature patrol meter 230 with 16 channels, that is, 16 calibration devices 200 may share one temperature patrol meter 230 to simultaneously calibrate the temperature of 16 devices. Of course, in other embodiments, the number of channels of the temperature patrol meter 230 may be other numbers, which may be determined according to actual needs.

[0118] The embodiment of the present application also provides a temperature calibration device 200, wherein the temperature calibration device 200 is the calibration device 200 in the above-mentioned temperature automatic calibration system 1000. In general, the temperature calibration device 200 has a simple structure, low cost, simple calibration operation, and accurate calibration, which is conducive to wide promotion and application.

[0119] The embodiment of the present application also provides a temperature automatic calibration method, in which N calibration points are provided, wherein N is a positive integer greater than or equal to 3. The predetermined flow rates corresponding to the N calibration points gradually increase, wherein the predetermined flow rate corresponding to the first current calibration point is the minimum predetermined flow rate; and the predetermined flow rate corresponding to the Nth current calibration point is the maximum predetermined flow rate. It should be noted that the specific values ​​of the predetermined flow rates corresponding to the N calibration points can be determined according to actual needs, and it is only necessary to ensure that they can be gradually increased in sequence.

[0120] In the embodiment of the present application, the temperature automatic calibration method uses the calibration device 200 to automatically calibrate the liquid returned from the liquid purification device 100, the predetermined flow rate corresponding to the N calibration points, and the heating temperature of each calibration point one by one. It can be understood that the temperature automatic calibration method automatically switches the calibration points in sequence according to the predetermined flow rate from small to large to perform temperature calibration. In this way, omissions can be avoided and orderly calibration can be facilitated; secondly, the influence of the temperature retained at the previous calibration point on the heating of the next calibration point can be reduced, thereby improving the calibration accuracy.

[0121] Exemplarily, in some specific implementations of this embodiment, there may be 5 calibration points, that is, N=5. Taking the liquid purification device 100 as a blood purification device 100 as an example, the predetermined flow rates corresponding to the 5 calibration points may be 15ml / min, 80ml / min, 160ml / min, 200ml / min, and 400ml / min, respectively. Obviously, the predetermined flow rate of the first calibration point is the minimum predetermined flow rate of 15ml / min, and the predetermined flow rate of the fifth calibration point is the maximum predetermined flow rate of 400ml / min. Of course, in other specific implementations, the specific flow rate of the corresponding predetermined flow rate of each calibration point may adopt other values. For the convenience of description, the following will be described by taking the 5 calibration points as an example.

[0122] In the embodiments of the present application, Figure 8 and Fig. 9 As shown, the temperature automatic calibration method includes the following:

[0123] Step S1 is a calibration start step. Step S1 includes:

[0124] Step S11: Connect the constant temperature liquid circulation device 210 of the calibration device 200 to the heating device 140 and the liquid purifier of the liquid purification equipment 100 to form a circulating liquid circuit.

[0125] Optionally, when the temperature patrol meter 230 is a single-channel temperature patrol meter 230, Figure 1 The structure shown in the figure connects the calibration device 200 to the liquid purification device 100 in a detachable manner; when the temperature inspection instrument 230 is a multi-channel temperature inspection instrument 230, it can be used according to Figure 7 The structure shown detachably connects a plurality of calibration devices 200 to a plurality of liquid purification equipment 100 to form a plurality of circulating liquid circuits.

[0126] Step S12: Start the calibration device 200 and the liquid purification device 100, and heat the liquid in the constant temperature liquid circulation device 210 to a standard temperature value T0 and then keep it warm.

[0127] Exemplarily, the constant temperature liquid circulation device 210 may be a constant temperature water tank, and the standard temperature value T0 is 37°C; the constant temperature water tank, the liquid purification device 100, the temperature inspection instrument 230, etc. are started, and the water in the constant temperature water tank is heated to 37°C and then kept warm, ready for calibration. Then click "Start" on the screen of the display 160 of the liquid purification device 100 to start the calibration of the current calibration point, wherein the predetermined flow rate of the initial calibration point is the minimum predetermined flow rate, for example, the predetermined flow rate of the first calibration point mentioned above, 15 ml / min.

[0128] Step S2 is a step of heating at the current target heating temperature value T1 at the current calibration point. Step S2 includes:

[0129] The driving pump 120 of the liquid purification device 100 operates at a predetermined flow rate of the current calibration point, and the heating device 140 heats the liquid purified by the liquid purifier according to the current target heating temperature value T1.

[0130] Among them, the flow rate of the initial current calibration point is the minimum predetermined flow rate; the initial current target heating temperature value of each current calibration point is the default machine target heating temperature value of the device.

[0131] Exemplarily, taking the above-mentioned 5 calibration points as an example, in step S2, the initial current calibration point, that is, the calibration point that is calibrated first, corresponds to a predetermined flow rate of 15 ml / min, and the initial target heating temperature value T1 at the predetermined flow rate of 15 ml / min is the default machine target heating temperature value of the blood purification device 100. If during calibration, it is detected that the initial target heating temperature value T1 does not meet expectations, the target heating temperature value T1 needs to be updated to a new target heating temperature value T1' to calibrate the target heating temperature value T1. If several tests still fail to meet expectations, the current target heating temperature value T1 needs to be continuously updated until the heating temperature of the heated liquid meets expectations, and the corresponding current target heating temperature value T1 or T1' that meets expectations is used as the target heating temperature value corresponding to the current calibration point at the predetermined flow rate when the blood purification device 100 is actually working.

[0132] Step S3 is a step of obtaining the actual heating temperature value. Step S3 includes:

[0133] The second temperature sensor 220 of the calibration device 200 obtains the actual heating temperature value T2 of the return liquid at the outlet side of the heating device 140 , and transmits the actual heating temperature to the control device 150 of the liquid purification equipment 100 .

[0134] In some specific embodiments of the present application, in step S3, the step of obtaining the actual heating temperature value T2 of the reinfused liquid specifically includes:

[0135] The second temperature sensor 220 detects the liquid temperature at the outlet 1413 of the heating device 140 in real time, and outputs the liquid temperature as the actual heating temperature value T2 when it is detected that the error of the liquid temperature at the outlet 1413 is within the first preset time period and remains within the preset error range.

[0136] It is understandable that the liquid temperature detected by the second temperature sensor 220 at the outlet 1413 of the heating device 140 may be changed frequently. Only when the error of a certain temperature changes within a preset error range and is maintained for a first preset time, can the temperature be used as the actual heating temperature value T2 and fed back to the control device 150 by the temperature patrol meter 230. Otherwise, the temperature patrol meter 230 will not feed back to the control device 150.

[0137] Optionally, in some specific embodiments of the present application, the first preset time length may be 2 minutes, and the preset error range may be ±0.2° C. Of course, in other specific embodiments, the first preset time length and the preset error range may also be other suitable values, which are not particularly limited here.

[0138] Step S4 is a step of comparing the actual heating temperature value T2 with the standard temperature value T0. Figure 8 and Fig. 9 As shown, step S4 includes:

[0139] If the actual heating temperature value T2 detected in step S3 is not within the preset temperature range, the calibration target heating temperature value T1' is obtained according to the preset calibration formula, and the current target heating temperature value T1 in step S2 is updated to the calibration target heating temperature value T1', and the predetermined flow rate of the current calibration point is used to repeat steps S2 to S4 in sequence until the actual heating temperature value T2 is within the preset temperature range.

[0140] Optionally, the above-mentioned liquid purification device 100 can be a blood purification device 100. In this way, in order to adapt to the human blood system and ensure the treatment effect of the patient, the standard temperature value T0 is 37°C, and the above-mentioned preset temperature range is 36.8°C to 37.2°C.

[0141] In addition, the calibration formula in step S4 may be as follows:

[0142] Calibration target heating temperature value T1' = calibration coefficient K * current target heating temperature value T1

[0143] Wherein, the calibration coefficient K=standard temperature value T0 / actual heating temperature value T2.

[0144] Exemplarily, if the actual heating temperature value T2 detected by the second temperature sensor 220 in step S4 is not within the range of 36.8°C to 37.2°C, for example, T2 is 37.5°C, it indicates that the current target heating temperature value T1 in step S2 is too high. In this case, calibration needs to be performed through a calibration formula to obtain T1'. In this situation, T1' < T1, and the control device 150 can control the heating temperature of the heating element 142 to be updated from T1 to T1', thereby reducing the heating temperature of the heating element 142. Conversely, it indicates that the current target heating temperature value T1 in step S2 is too low, and it needs to be calibrated to a higher T1'. At this time, T1' > T1, and the control device 150 can control the heating temperature of the heating element 142 to be updated from T1 to T1', thereby increasing the heating temperature of the heating element 142.

[0145] If the actual heating temperature value T2 is within the preset temperature range, it is further determined whether the actual heating temperature value T2 reaches the preset temperature range for the first time.

[0146] See, for example, Figure 8 and Fig. 9 , if so, stop heating, wait for the temperature to drop, and then sequentially execute steps S2 to S4 until the actual heating temperature value T2 is within the preset temperature range for the second time.

[0147] It can be understood that if it is detected that the actual heating temperature value T2 only reaches the preset temperature range for the first time, it still cannot ensure that the heating element 142 is heated according to the current target heating temperature value T1. Whether the actual heating temperature value T2 obtained during actual operation is within the preset temperature range. Therefore, it is still necessary to further verify whether the current target heating temperature value T1 in step S2 can be used as the target heating temperature value for actual operation under the current calibration point of the liquid purification device 100.

[0148] In some specific embodiments of the present application, as Figure 8 and Fig. 9 shown, in step S4, the step of stopping heating and waiting for the temperature to drop specifically includes:

[0149] The heating device 140 stops heating under the control of the control device 150.

[0150] The driving pump 120 operates at the maximum predetermined flow rate for a second preset duration to cool the liquid outside the constant temperature liquid circulation device 210.

[0151] It can be understood that if it is detected that the actual heating temperature value T2 only reaches the preset temperature range for the first time, it is necessary to quickly dissipate the heat of the feedback liquid and prepare for the second heating to verify whether the actual heating temperature value T2 can be used as the target heating temperature value for actual operation under the current calibration point of the liquid purification device 100.

[0152] If not, the actual heating temperature value T2 has reached the preset temperature range twice, then the calibration of the current calibration point is qualified, and the current target heating temperature value in step S2 is saved as the final target heating temperature value of the current calibration point. The calibration of the current calibration point is completed, and the current calibration point is switched to the next calibration point, and then steps S2 to S4 are executed in sequence until the calibration of the Nth calibration point is completed.

[0153] Optionally, the maximum predetermined flow rate may adopt the predetermined flow rate corresponding to the fifth standard point mentioned above, 400 ml / min, and the second preset time length may be 1 min. Exemplarily, when it is determined that T2 detected in step S3 is within the range of 36.8°C to 37.2°C, the control device 150 controls the heating element 142 to stop heating, and controls the drive pump 120 to run at 400ml / min for 1min for cooling, so as to remove the heat at the calibration point, such as the predetermined flow rate of 15ml / min, through a large flow rate, to avoid the result of the subsequent second calibration being affected by it, and then controls the drive pump 120 to run at 15ml / min, and controls the heating element 142 to reheat the liquid according to the current target heating temperature value T1 or T1', and judges whether the actual heating temperature value T2 detected by the second temperature sensor 220 again is within 36.8°C to 37.2°C. If so, it means that it reaches 36.8°C to 37.2°C for the second time, and saves the current target heating temperature value T1 or T1' at the 15ml / min standard point as the target heating temperature value used by the blood purification equipment 100 when it actually works at the 15ml / min standard point. At this point, the calibration at the 15ml / min standard point is completed.

[0154] Then, the control device 150 can control the driving pump 120 to run at 80ml / min, and then execute steps S2 to S4 in sequence; after the calibration at the standard point of 80ml / min is completed, the control device 150 can control the driving pump 120 to run at 160ml / min, and then execute steps S2 to S4 in sequence; after the calibration at the standard point of 160ml / min is completed, the control device 150 can control the driving pump 120 to run at 200ml / min, and then execute steps S2 to S4 in sequence; after the calibration at the standard point of 200ml / min is completed, the control device 150 can control the driving pump 120 to run at 400ml / min, and then execute steps S2 to S4 in sequence; after the calibration at the standard point of 400ml / min is completed, step S5 can be entered.

[0155] Step S5: After the N calibration points are calibrated sequentially, the liquid purification equipment 100 and the calibration device 200 automatically stop.

[0156] For example, after the N calibration points are calibrated in sequence, the screen of the display 160 of the liquid purification device 100 may prompt that the calibration is completed, and after the user clicks to confirm, the liquid purification device 100 and the calibration device 200 automatically stop. It should be noted that the temperature automatic calibration method can be implemented using the above-mentioned temperature automatic calibration system 1000, which is also the calibration method of the above-mentioned temperature automatic calibration system 1000.

[0157] In summary, compared with the prior art, the temperature automatic calibration method has at least the following beneficial effects:

[0158] The temperature automatic calibration method can automatically switch calibration points of different flow rates for temperature calibration, which is beneficial to improve the calibration efficiency of liquid purification equipment, save labor costs, and reduce calibration errors and shorten the delivery time of liquid purification equipment. In addition, by automatically switching calibration points according to predetermined flow rates from small to large, it is possible to avoid missing calibration points and reduce the influence of the temperature retained at the previous calibration point on the heating of the current calibration point, thereby improving the calibration accuracy.

[0159] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various changes and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the scope of the claims of the present application.

Claims

1. A temperature automatic calibration system, characterized in that: The automatic temperature calibration system comprises a liquid purification device and a calibration device, wherein the calibration device is detachably connected to the liquid purification device and is used to assist the liquid purification device in automatically calibrating the heating temperature of the purified liquid; The liquid purification equipment comprises: Control devices; A liquid purifier, connected to the target object through a first pipeline, and used to purify the liquid output by the target object; a driving pump, disposed in the first pipeline, electrically connected to the control device, and used to provide driving force for the target object to input the liquid into the liquid purifier; and The heating device comprises a body, wherein a heating chamber is formed in the body, and an inlet and an outlet communicated with the heating chamber are provided, wherein the inlet is used for inputting the liquid purified by the liquid purifier into the heating chamber; and the outlet is used for outputting the liquid in the heating chamber to be returned to the target object through a second pipeline; The heating device also includes: a heating element, disposed on the body and electrically connected to the control device, and used for heating the liquid in the heating chamber under the control of the control device; and a first temperature sensor, electrically connected to the control device, for collecting a current first temperature signal of the liquid at the inlet side and / or the outlet side of the heating chamber, and feeding the first temperature signal back to the control device; Wherein, the calibration device comprises: A constant temperature liquid circulation device, which serves as the target object during temperature calibration and can circulate liquid inside to maintain the target temperature; the constant temperature liquid circulation device is detachably connected to the driving pump through the first pipeline, and is detachably connected to the heating device through the second pipeline; A second temperature sensor is used to collect a second temperature signal of the liquid actually heated at the outlet side of the heating chamber; A temperature patrol meter is electrically connected to the second temperature sensor and the control device, and is used to transmit the second temperature signal to the control device so that the control device controls the liquid purification equipment to calibrate the first temperature signal according to the second temperature signal.

2. The automatic temperature calibration system according to claim 1, characterized in that: The second temperature sensor is installed in the second pipeline, and the second temperature sensor includes a temperature measuring part, which is used to collect the actual second temperature signal of the heated liquid that is returned to the constant temperature liquid circulation device through the second pipeline.

3. The automatic temperature calibration system according to claim 2, characterized in that: A temperature measuring hole is provided in the second pipeline at the outlet side of the heating device; the temperature measuring part is closedly inserted into the temperature measuring hole to collect a second temperature signal of the heated liquid in the second pipeline; Alternatively, the calibration device further comprises: A three-way connector having a first interface, a second interface and a third interface that are interconnected; The first interface is connected to the outlet of the heating device via a joint and a section of the second pipeline in sequence, the second interface is connected to the constant temperature liquid circulation device via another section of the second pipeline, and the temperature measuring part is plugged into the third interface.

4. The automatic temperature calibration system according to claim 3, characterized in that: The distance between the temperature measuring part and the outlet of the heating device is 1 cm to 2 cm; And / or, the second temperature sensor further comprises a connecting wire, one end of which is connected to the temperature measuring part, and the other end of which is connected to the temperature inspection instrument; The calibration device also includes: The installation tube has a first end and a second end that are connected to each other; the first end of the installation tube is connected to the third interface, and the second end is for the temperature measuring part to pass through and extend to the third interface and for part of the connecting line to extend into.

5. The automatic temperature calibration system according to claim 4, characterized in that: The calibration device further comprises a positioning clamp, which is used to clamp the connecting wire in the installation tube to assist in positioning the temperature measuring part at a target position; And / or, the calibration device further comprises a packaging tube, one end of which is connected to the second end of the mounting tube, and the other end of which is used for the connecting wire in the mounting tube to pass through and is packaged with a seal.

6. The automatic temperature calibration system according to any one of claims 1 to 5, characterized in that: The temperature inspection instrument is a multi-channel temperature inspection instrument, which is used to connect multiple liquid purification devices at the same time; Wherein, the temperature patrol meter is connected to the control device of each of the liquid purification devices via a signal transmission line, so as to transmit the second temperature signal collected by the corresponding second temperature sensor to the control device; And / or, the liquid purification device is a blood purification device.

7. A temperature calibration device, characterized in that: The temperature calibration device adopts the calibration device according to any one of claims 1 to 6.

8. A temperature automatic calibration method, characterized in that: In the temperature automatic calibration method, N calibration points are provided, where N is a positive integer greater than or equal to 3; the predetermined flow rates corresponding to the N calibration points gradually increase, wherein the predetermined flow rate corresponding to the first current calibration point is the minimum predetermined flow rate; and the predetermined flow rate corresponding to the Nth current calibration point is the maximum predetermined flow rate; The automatic temperature calibration method uses a calibration device to automatically calibrate the liquid returned from the liquid purification device, in sequence, at the predetermined flow rate corresponding to the N calibration points, and at the heating temperature of each calibration point; The automatic temperature calibration method comprises: Step S1: Calibration start step Connect the constant temperature liquid circulation device of the calibration device to the heating device and the liquid purifier of the liquid purification device to form a circulating liquid circuit; start the calibration device and the liquid purification device, and heat the liquid in the constant temperature liquid circulation device to a standard temperature value T0 and then keep it warm; Step S2: Heating step according to the current target heating temperature value T1 at the current calibration point The driving pump of the liquid purification device operates at the predetermined flow rate of the current calibration point, and the heating device heats the liquid purified by the liquid purifier according to the current target heating temperature value T1; wherein the initial flow rate of the current calibration point is the minimum predetermined flow rate; the initial current target heating temperature value of each current calibration point is the default machine target heating temperature value of the device; Step S3: Obtaining the actual heating temperature value The second temperature sensor of the calibration device obtains the actual heating temperature value T2 of the return liquid at the outlet side of the heating device, and transmits the actual heating temperature to the control device of the liquid purification equipment; Step S4: Compare the actual heating temperature value T2 with the standard temperature value T0 If the actual heating temperature value T2 is not within the preset temperature range, the calibration target heating temperature value T1' is obtained according to the preset calibration formula, and the current target heating temperature value T1 is updated to the calibration target heating temperature value T1', and the predetermined flow rate of the current calibration point is used to repeat the steps S2 to S4 in sequence until the actual heating temperature value T2 is within the preset temperature range; If the actual heating temperature value T2 is within the preset temperature range, further determining whether the actual heating temperature value T2 reaches the preset temperature range for the first time; If yes, then stop heating and wait for the temperature to drop, and then execute the steps S2 to S4 in sequence until the actual heating temperature value T2 is within the preset temperature range for the second time; If not, the actual heating temperature value T2 has reached the preset temperature range twice, then the calibration of the current calibration point is qualified, the current target heating temperature value in step S2 is saved as the final target heating temperature value of the current calibration point, the calibration of the current calibration point is completed, the current calibration point is switched to the next calibration point, and then the steps S2 to S4 are sequentially executed until the calibration of the Nth calibration point is completed; Step S5: After the N calibration points are calibrated in sequence, the liquid purification equipment and the calibration device automatically stop.

9. The automatic temperature calibration method according to claim 8, characterized in that: In step S3, the step of obtaining the actual heating temperature value T2 of the reinfused liquid specifically includes: The second temperature sensor detects the liquid temperature at the outlet of the heating device in real time, and when the error of the liquid temperature at the outlet is detected to be within a first preset time length and within a preset error range, the second temperature sensor outputs the liquid temperature as the actual heating temperature value T2; And / or, in step S4, the step of stopping heating and waiting for cooling specifically includes: The heating device stops heating under the control of the control device; The driving pump operates at the maximum predetermined flow rate for a second preset time period to cool the liquid outside the constant temperature liquid circulation device.

10. The automatic temperature calibration method according to claim 8 or 9, characterized in that: The liquid purification device is a blood purification device; And / or, the calibration formula in step S4 is as follows: Calibration target heating temperature value T1' = calibration coefficient K * current target heating temperature value T1 Wherein, calibration coefficient K = standard temperature value T0 / actual heating temperature value T2; And / or, the standard temperature value T0 is 37°C; And / or, there are 5 calibration points, and the predetermined flow rates corresponding to the 5 calibration points are 15 ml / min, 80 ml / min, 160 ml / min, 200 ml / min, and 400 ml / min, respectively, wherein the minimum predetermined flow rate is 15 ml / min, and the maximum predetermined flow rate is 400 ml / min; And / or, the preset temperature range is 36.8°C to 37.2°C.

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