Antibacterial, breathable and biodegradable medical film material as well as preparation method and application thereof

Abstract

The invention provides an antibacterial breathable biodegradable medical film material as well as a preparation method and application thereof, and relates to the technical field of preparation of medical film materials. The film material comprises PLCL particles, polylactic acid particles, polyhydroxyalkanoate, a plasticizer, a lubricant and an antibacterial agent. The antibacterial plastic comprises the following components in parts by mass: 80-100 parts of PLCL particles, 10-20 parts of polylactic acid particles, 1-5 parts of polyhydroxyalkanoate, 1-3 parts of a plasticizer, 1-3 parts of a lubricant and 0.5-1 part of an antibacterial agent. The medical-grade film prepared by the invention has the characteristics of softness, skin friendliness, high elasticity, good transparency, strong water resistance and air permeability, good antibacterial effect and the like, also has good biodegradability, is green and environment-friendly, and does not cause environmental stress.

Description

Technical Field

[0001] The invention provides an antibacterial, breathable and biodegradable medical film material and a preparation method and application thereof, and relates to the technical field of medical film material preparation. Background Art

[0002] Traditional medical film materials, such as polyethylene (PE), polyvinyl chloride (PVC) and thermoplastic polyurethane (TPU), are widely used in the medical field due to their waterproof and liquid-proof properties. However, these materials also have many defects in actual use. The main problems include: Poor air permeability: PE and PVC films are not breathable enough, resulting in the inability of the covered wound area to sweat normally, causing itching, dampness and heat, and affecting wound healing. Although TPU film has a certain degree of air permeability, it is still not enough to completely solve this problem. Non-biodegradable: PE, PVC and TPU films are not biodegradable, resulting in a large amount of non-degradable medical waste generated by hospitals every day, which puts great pressure on the environment. Lack of antibacterial properties: These traditional film materials do not have antibacterial effects, increasing the risk of re-infection of the wound.

[0003] Patents CN116041941A, CN113337047B, CN112409777A, CN110330712B, etc. all use PE, PVC, and TPU as the main materials, which are basically not biodegradable. In addition, researchers have also proposed some new medical film materials, which not only have the advantages of being waterproof and liquid-proof, but also have good air permeability, biodegradability, and antibacterial properties. Aqueous polyurethane dispersions (PUDs): This material has attracted much attention due to its environmental friendliness, biodegradability, and antibacterial properties. By adjusting the structure of polyester and polyisocyanate, its degradation rate and mechanical properties can be regulated to make it suitable for medical applications. Thermoplastic starch (TPS) composite materials: TPS is blended with other biodegradable polymers (such as polycaprolactone) to provide good mechanical properties and biodegradability. This material can decompose in the natural environment and reduce environmental pollution. Bio-based TPU: TPU made from bio-based polyesters (such as succinic acid and 1,3-propylene glycol) not only has the excellent mechanical properties of traditional TPU, but is also biodegradable, and is expected to become a sustainable alternative to PVC. Antibacterial TPU composites: By adding antibacterial agents (such as nanosilver) to the TPU matrix, the antibacterial properties of the material can be significantly improved, reducing the risk of bacterial infection on wounds. This composite material has broad application prospects in medical devices and wound dressings. Antibacterial coating: Adding antibacterial coatings (such as polylysine coatings) to the surface of traditional materials can effectively inhibit bacterial growth and enhance the antibacterial properties of the materials. However, these solutions still face some challenges and problems, which require further research and development and optimization. Biodegradable materials still have a gap in mechanical properties compared with traditional materials, and stability under humidity and temperature changes is an important issue. In antibacterial TPU composites, the release rate and durability of antibacterial agents such as nanosilver need to be optimized. The durability and adhesion of antibacterial coatings are also issues that need to be addressed. The coating may wear or fall off during use, affecting its antibacterial effect. The potential toxicity and drug resistance caused by long-term use of antimicrobial agents also need to be paid attention to. In addition, the production process and cost control of the above-mentioned new materials are also important factors limiting their application. Summary of the invention

[0004] In order to solve the above problems, the present invention provides an antibacterial, breathable and biodegradable medical film material and a preparation method and application thereof. The specific scheme is as follows:

[0005] An antibacterial, breathable and biodegradable medical film material comprises PLCL particles, polylactic acid particles, polyhydroxyalkanoate, a plasticizer, a lubricant and an antibacterial agent.

[0006] Preferably, the components include, by mass, 80 to 100 parts of PLCL particles, 10 to 20 parts of polylactic acid particles, 1 to 5 parts of polyhydroxyalkanoate, 1 to 3 parts of plasticizer, 1 to 3 parts of lubricant, and 0.5 to 1 part of antibacterial agent.

[0007] Preferably, the plasticizer includes one or more of tri-n-butyl citrate, acetyl citrate, and dibutyl phthalate.

[0008] Preferably, the melt index of the PLCL particles is 5-40 g / 190°C, 2.16 kg*10 min; the melt index of the polylactic acid particles is 5-40 g / 190°C, 2.16 kg*10 min.

[0009] Further preferably, the PLCL particles have a melting temperature of 5-20 g / 160°C, 2.16 kg*10 min; the polylactic acid particles have a melting temperature of 5-20 g / 190°C, 2.16 kg*10 min.

[0010] Preferably, the lubricant includes one or more of stearic acid, zinc stearate, polyethylene wax, paraffin wax, and silicone powder.

[0011] Preferably, the antibacterial agent is a guanidine compound.

[0012] Preferably, the guanidine compound includes one or more of porous polyguanidine, polyether guanidine, polyacrylamide guanidine, and polycarboxylate guanidine, more preferably polyhexamethylene biguanide.

[0013] Preferably, the preparation method of the PLCL particles comprises: adding lactide, ε-caprolactone monomer, a catalyst and an initiator into a reaction kettle, introducing nitrogen after mixing, and heating for reaction; after the reaction is completed, vacuum devolatilization is performed, and the obtained product is melt-extruded, pelletized and dried to obtain PLCL particles.

[0014] Preferably, the mass ratio of the lactide to the ε-caprolactone monomer is (4:1) to (9:1); more preferably 4:1.

[0015] Preferably, the catalyst is added in an amount of 0.001 to 0.5 wt % of the total mass of lactide and ε-caprolactone, and the initiator is added in an amount of 0.01 to 0.7 wt % of the total mass of lactide and ε-caprolactone.

[0016] Preferably, the catalyst is a bimetallic aluminum alkyl complex represented by structural formula I or structural formula II:

[0017]

[0018] Wherein, R1 is selected from hydrogen, C1-C12 straight chain, branched chain or cyclic alkyl; R2 is selected from C1-C6 straight chain or branched alkyl, C1-C6 straight chain or branched alkoxy. The bimetallic aluminum alkyl complex catalyst includes but is not limited to one of the structures shown in the following formulas (I) to (VI):

[0019]

[0020]

[0021]

[0022] Preferably, the initiator includes one or more of benzyl alcohol, 1,4-butanediol, ethylene glycol, glycerol, neopentyl glycol, 2-aminoethanol, triethanolamine, 1,3-propylene glycol, and 1,2-propylene glycol.

[0023] The present invention also provides a method for preparing the above-mentioned antibacterial, breathable and biodegradable medical film material, comprising: premixing the components in the formula to obtain a mixed material, and extruding the mixed material into a film by a casting method; wherein the barrel temperature is 155-165°C; the filter screen temperature is 175-180°C; the elbow temperature is 175-180°C; the connection temperature is 178-185°C; and the die temperature is 185-190°C.

[0024] The present invention also provides application of the antibacterial, breathable and biodegradable medical film material in the preparation of medical materials.

[0025] The beneficial effects of the present invention are mainly reflected in the following aspects:

[0026] 1. The present invention adopts a bimetallic aluminum alkyl complex as a catalyst, which can effectively regulate the difference in the reactivity ratio between lactide and ε-caprolactone in the copolymerization, and realize the random copolymerization of the two. The PLCL particles prepared by using the catalyst have good transparency and extremely high flexibility. The elongation at break can reach more than 500%, and it can also be directly used as a film.

[0027] 2. The medical-grade film produced by the present invention has the characteristics of being soft, skin-friendly, highly elastic, transparent, waterproof and breathable, and also has good biodegradability, is green and environmentally friendly, and will not cause environmental pressure.

[0028] 3. The polyhydroxyalkanoate added in the present invention is a biodegradable polymer. Although it has no antibacterial property itself, it can affect the overall crystallinity and microstructure of the material, and can produce a synergistic effect with polyhexamethylene biguanide to further enhance its antibacterial and disinfection effect. It has excellent continuous antibacterial ability and prevents the risk of reinfection. It is especially popular in medical protection, such as wound dressings and surgery. DETAILED DESCRIPTION

[0029] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0030] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0031] The experimental methods in the following examples are conventional methods unless otherwise specified, and the experimental materials used in the following examples are purchased from commercial channels unless otherwise specified.

[0032] Example 1

[0033] An antibacterial, breathable and biodegradable medical film material and a preparation method and application thereof, the steps are as follows:

[0034] (1) Synthesis of PLCL:

[0035] Add 800 kg of lactide, 200 kg of ε-caprolactone monomer, 10 g of bimetallic aluminum alkyl complex (structural formula I), 100 g of initiator 1,4-butanediol into the reactor, control the reaction temperature to 175 ° C, react for 12 hours, and then carry out vacuum devolatilization for 1 hour, then extrude through a melt pump, and perform underwater pelletizing and drying. The melt index is tested to be 5.16 / 190 ° C, 2.16 kg * 10 min.

[0036]

[0037] (2) Raw material pretreatment:

[0038] The synthesized PLCL particles were placed in a vacuum drying oven set at 50°C for 8 hours, the polylactic acid particles (20g / 190°C, 2.16kg*10min) were placed in a vacuum drying oven set at 75°C for 6 hours, and the polyhydroxybutyrate was placed in a vacuum drying oven set at 75°C for 10 hours to ensure that the moisture content of each raw material was less than 0.01%;

[0039] (3) Material blending:

[0040] Take 100 parts of dried PLCL particles, 20 parts of polylactic acid particles, 1 part of polyhydroxybutyrate, 3 parts of tri-n-butyl citrate, 3 parts of polyethylene wax, and 1 part of polyhexamethylene biguanide, put them into a high-speed mixer, and mix them until the materials are uniform;

[0041] (4) Casting extrusion film:

[0042] The mixed materials are sent to a casting machine and extruded into a film; the process conditions for the extrusion film are: the barrel temperature is 155°C; the filter screen temperature is 175°C; the elbow temperature is 180°C; the connection temperature is 185°C; and the die temperature is 190°C.

[0043] Example 2

[0044] An antibacterial, breathable and biodegradable medical film material and a preparation method and application thereof, the steps are as follows:

[0045] (1) Synthesis of PLCL:

[0046] Add 800 kg of lactide, 200 kg of ε-caprolactone monomer, 20 g of bimetallic aluminum alkyl complex (structural formula II), 150 g of initiator 1,4-butanediol into the reactor, control the reaction temperature to 175 ° C, react for 7 hours, and then carry out vacuum devolatilization for 1 hour, then extrude through a melt pump, and perform underwater pelletizing and drying. The melt index is tested to be 12.46 / 190 ° C, 2.16 kg*10 min.

[0047]

[0048] (2) Raw material pretreatment:

[0049] The synthesized PLCL particles were placed in a vacuum drying oven set at 50°C for 6 hours, the polylactic acid particles (10g / 190°C, 2.16kg*10min) were placed in a vacuum drying oven set at 65°C for 6 hours, and the polyhydroxybutyrate was placed in a vacuum drying oven set at 75°C for 10 hours to ensure that the moisture content of each raw material was less than 0.01%;

[0050] (3) Material blending:

[0051] Take 100 parts of the dried PLCL particles, 15 parts of polylactic acid particles, 5 parts of polyhydroxybutyrate, 2 parts of acetyl citrate, 2 parts of paraffin, and 1 part of polyhexamethylene biguanide, put them into a high-speed mixer, and mix them until the materials are uniform;

[0052] (4) Casting extrusion film:

[0053] The mixed materials are sent to a casting machine and extruded into a film; the process conditions for the extrusion film are: the barrel temperature is 160°C; the filter screen temperature is 175°C; the elbow temperature is 178°C; the connection temperature is 185°C; and the die head temperature is 185°C.

[0054] Example 3

[0055] An antibacterial, breathable and biodegradable medical film material and a preparation method and application thereof, the steps are as follows:

[0056] (1) Synthesis of PLCL:

[0057] Add 800 kg of lactide, 200 kg of ε-caprolactone monomer, 40 g of bimetallic aluminum alkyl complex (structural formula III), 200 g of initiator 1,4-butanediol into the reactor, control the reaction temperature to 180°C, react for 6 hours, perform vacuum devolatilization for 1 hour, then extrude through a melt pump, perform underwater pelletizing and drying, and the melt index is tested to be 21.54 / 190°C, 2.16 kg*10 min.

[0058]

[0059] (2) Raw material pretreatment:

[0060] The synthesized PLCL particles were placed in a vacuum drying oven set at 50°C for 6 hours, the polylactic acid particles (20g / 190°C, 2.16kg*10min) were placed in a vacuum drying oven set at 65°C for 6 hours, and the polyhydroxybutyrate was placed in a vacuum drying oven set at 75°C for 10 hours to ensure that the moisture content of each raw material was less than 0.01%;

[0061] (3) Material blending:

[0062] Take 80 parts of dried PLCL particles, 10 parts of polylactic acid particles, 1 part of polyhydroxybutyrate, 1 part of acetyl citrate, 1 part of stearic acid, and 0.5 parts of polyhexamethylene biguanide, put them into a high-speed mixer, and mix until the materials are uniform;

[0063] (4) Casting extrusion film:

[0064] The mixed materials are sent to a casting machine and extruded into a film; the process conditions for the extrusion film are: the barrel temperature is 160°C; the filter screen temperature is 175°C; the elbow temperature is 178°C; the connection temperature is 185°C; and the die head temperature is 185°C.

[0065] Example 4

[0066] An antibacterial, breathable and biodegradable medical film material and a preparation method and application thereof, the steps are as follows:

[0067] (1) Synthesis of PLCL:

[0068] Add 800 kg of lactide, 200 kg of ε-caprolactone monomer, 15 g of bimetallic aluminum alkyl complex (structural formula IV), 120 g of initiator 1,4-butanediol into the reactor, control the reaction temperature to 170°C, react for 10 hours, perform vacuum devolatilization for 1 hour, then extrude through a melt pump, perform underwater pelletizing and drying, and the melt index is tested to be 6.73 / 190°C, 2.16 kg*10 min.

[0069]

[0070] (2) Raw material pretreatment:

[0071] The synthesized PLCL particles were placed in a vacuum drying oven set at 50°C for 6 hours, the polylactic acid particles (5g / 190°C, 2.16kg*10min) were placed in a vacuum drying oven set at 65°C for 6 hours, and the polyhydroxybutyrate was placed in a vacuum drying oven set at 75°C for 10 hours to ensure that the moisture content of each raw material was less than 0.01%;

[0072] (3) Material blending:

[0073] Take 100 parts of the dried PLCL particles, 15 parts of polylactic acid particles, 1 part of polyhydroxybutyrate, 1 part of dibutyl phthalate, 1 part of zinc stearate, and 1 part of polyhexamethylene biguanide, put them into a high-speed mixer, and mix them until the materials are uniform;

[0074] (4) Casting extrusion film:

[0075] The mixed materials are sent to a casting machine and extruded into a film; the process conditions for the extrusion film are: the barrel temperature is 165°C; the filter screen temperature is 180°C; the elbow temperature is 180°C; the connection temperature is 185°C; and the die temperature is 190°C.

[0076] Comparative Example 0

[0077] Medical grade thermoplastic polyurethane (TPU) film material.

[0078] Product Model: XM

[0079] Manufacturer: Covestro

[0080] Main Application

[0081] XM is a medical-grade thermoplastic polyurethane (TPU) film widely used in wound dressings, surgical diaphragms and other medical applications.

[0082] Its main features and uses include:

[0083] Comfort: The film is soft, suitable for skin contact, and feels comfortable when used.

[0084] Breathability: With good breathability, it helps the wound area to drain sweat and other body fluids and reduce discomfort.

[0085] Antibacterial: Low coefficient of friction prevents the film from rubbing against clothing, reducing the frequency of early replacement and reducing patient costs.

[0086] Cost-effective: Produced by blown film technology, with competitive price.

[0087] Low reflectivity: Matte surface reduces distracting reflections in bright environments such as operating rooms.

[0088] Material composition: Medical grade thermoplastic polyurethane (TPU)

[0089] Comparative Example 1

[0090] (1) Synthesis of PLCL:

[0091] Add 800 kg of lactide and 200 kg of ε-caprolactone monomer into the reactor, add 20 g of neodymium trifluoride catalyst, adjust the amount of initiator 1,4-butanediol to 100 g, control the reaction temperature to 160°C, extend the reaction time to 12 h, and then perform vacuum devolatilization for 1 h.

[0092] Then it is extruded by a melt pump and then pelletized and dried underwater. The melt index is tested to be 6.73 / 190°C, 2.16kg*10min.

[0093] (2) Raw material pretreatment:

[0094] The synthesized PLCL particles were placed in a vacuum drying oven set at 50°C for drying for 6 hours, the polylactic acid particles (5g / 190°C, 2.16kg*10min) were placed in a vacuum drying oven set at 65°C for drying for 6 hours, and the polyhydroxybutyrate was placed in a vacuum drying oven set at 75°C for drying for 10 hours, ensuring that the moisture content in each raw material was less than 0.01%.

[0095] (3) Material blending:

[0096] Take 100 parts of the dried PLCL particles, 15 parts of polylactic acid particles, 1 part of polyhydroxybutyrate, 1 part of dibutyl phthalate, 1 part of zinc stearate, and 1 part of polyhexamethylene biguanide, put them into a high-speed mixer, and mix them until the materials are uniform.

[0097] (4) Casting extrusion film:

[0098] The mixed materials are sent to a casting machine and extruded into a film; the process conditions for the extrusion film are: the barrel temperature is 165°C; the filter screen temperature is 180°C; the elbow temperature is 180°C; the connection temperature is 185°C; and the die temperature is 190°C.

[0099] Comparative Example 2

[0100] (1) Synthesis of PLCL:

[0101] Add 800 kg of lactide and 200 kg of ε-caprolactone monomer into the reactor, add 30 g of diphenyltin oxide as a catalyst, adjust the amount of initiator 1,4-butanediol to 100 g, control the reaction temperature to 150°C, and the reaction time to 8 hours, followed by vacuum devolatilization for 1 hour.

[0102] Then it is extruded by a melt pump and then pelletized and dried underwater. The melt index is tested to be 6.73 / 190°C, 2.16kg*10min.

[0103] (2) Raw material pretreatment:

[0104] The synthesized PLCL particles were placed in a vacuum drying oven set at 50°C for drying for 6 hours, the polylactic acid particles (5g / 190°C, 2.16kg*10min) were placed in a vacuum drying oven set at 65°C for drying for 6 hours, and the polyhydroxybutyrate was placed in a vacuum drying oven set at 75°C for drying for 10 hours, ensuring that the moisture content in each raw material was less than 0.01%.

[0105] (3) Material blending:

[0106] Take 100 parts of the dried PLCL particles, 15 parts of polylactic acid particles, 1 part of polyhydroxybutyrate, 1 part of dibutyl phthalate, 1 part of zinc stearate, and 1 part of polyhexamethylene biguanide, put them into a high-speed mixer, and mix them until the materials are uniform.

[0107] (4) Casting extrusion film:

[0108] The mixed materials are sent to a casting machine and extruded into a film; the process conditions for the extrusion film are: the barrel temperature is 165°C; the filter screen temperature is 180°C; the elbow temperature is 180°C; the connection temperature is 185°C; and the die temperature is 190°C.

[0109] The difference between Comparative Example 3 and Example 4 is that the bimetallic aluminum alkyl complex is represented by the following structural formula, and other conditions remain unchanged.

[0110]

[0111] The difference between Comparative Example 4 and Example 4 is that polyhydroxybutyrate is not included in the formula.

[0112] The difference between Comparative Example 5 and Example 4 is that the antibacterial agent polyhexamethylene biguanide is not included in the formula.

[0113] Performance Testing

[0114] The performance of the medical-grade films prepared in Examples 1 to 5 was tested as follows:

[0115] (1) The air permeability test shall be carried out in accordance with the provisions of "Water Vapor Permeability Test Method" in Appendix C of YY / T 0148-2006;

[0116] (2) Water absorption test: The test was carried out in accordance with the "Water absorption test method" in YY / T 0471.1-2004 to obtain the average amount of liquid absorbed by the film dressing on the wound surface within 30 minutes (g / 100cm 2 );

[0117] (3) The antibacterial rate test is carried out in accordance with the provisions of YY / T 0471.5-2004 on antibacterial properties in a semi-humid state;

[0118] (4) Film mechanical properties test: The mechanical properties test was carried out on a universal testing machine according to the national standard GB / T 1040.3-2006;

[0119] (5) Biodegradability test: The biodegradability rate is tested under industrial composting conditions in the national standard GB / T 41010-2021, and the test period is 180 days;

[0120]

[0121] It can be seen from the data results that the medical film material prepared by the present invention has excellent waterproof and breathable properties, the specific preparation method of PLCL provides excellent mechanical properties, the compounding and addition of polyhydroxyalkanoate and polyhexamethylene biguanide gives the film long-lasting antibacterial properties, and its light transmittance and mechanical properties are also quite excellent, making it have a wider application value in the medical field, especially as a medical transparent dressing or surgical film. In addition, the medical film prepared by the present invention has a biodegradability rate of more than 95%, is green and environmentally friendly, and does not cause environmental pressure.

[0122] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0123] The present invention and its implementation methods are described above, which is not restrictive. What is shown is only one of the implementation methods of the present invention, and the actual application is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design methods and embodiments similar to the technical solution without creativity without departing from the purpose of the invention, they should all fall within the protection scope of the present invention.

Claims

1. An antibacterial, breathable and biodegradable medical film material, characterized by: It includes PLCL particles, polylactic acid particles, polyhydroxyalkanoate, plasticizer, lubricant, and antibacterial agent; the components are calculated by weight as follows: 80-100 parts of PLCL particles, 10-20 parts of polylactic acid particles, 1-5 parts of polyhydroxyalkanoate, 1-3 parts of plasticizer, 1-3 parts of lubricant, and 0.5-1 part of antibacterial agent.

2. The antibacterial, breathable and biodegradable medical film material according to claim 1, characterized in that: The plasticizer includes one or more of tri-n-butyl citrate, acetylcitrate, and dibutyl phthalate; the lubricant includes one or more of stearic acid, zinc stearate, polyethylene wax, paraffin, and silicone powder; and the antibacterial agent is a guanidine compound.

3. The antibacterial, breathable and biodegradable medical film material according to claim 2, characterized in that: The guanidine compound includes one or more of porous polyguanidine, polyether guanidine, polyacrylamide guanidine, and polycarboxylate guanidine, and polyhexamethylene biguanide is more preferred.

4. The antibacterial, breathable and biodegradable medical film material according to claim 1, characterized in that: The melt index of the PLCL particles is 5-40 g / 190° C., 2.16 kg*10 min; the melt index of the polylactic acid particles is 5-40 g / 190° C., 2.16 kg*10 min.

5. The antibacterial, breathable and biodegradable medical film material according to claim 1, characterized in that: The preparation method of the PLCL particles comprises: adding lactide, ε-caprolactone monomer, a catalyst and an initiator into a reaction kettle, introducing nitrogen after mixing, and heating for reaction; after the reaction is completed, performing vacuum devolatilization, and performing melt extrusion, pelletizing and drying of the obtained product to obtain the PLCL particles.

6. The antibacterial, breathable and biodegradable medical film material according to claim 5, characterized in that: The mass ratio of the lactide to the ε-caprolactone monomer is (4:1) to (9:1); the amount of the catalyst added is 0.001 to 0.5 wt% of the total mass of the lactide and ε-caprolactone, and the amount of the initiator added is 0.01 to 0.7 wt% of the total mass of the lactide and ε-caprolactone.

7. The antibacterial, breathable and biodegradable medical film material according to claim 5, characterized in that: The catalyst is a bimetallic aluminum alkyl complex shown in structural formula I or structural formula II: Among them, R1 is selected from one of hydrogen, C1~C12 linear, branched or cyclic alkyl groups; R2 is selected from one of C1~C6 linear or branched alkyl groups, C1~C6 linear or branched alkoxy groups.

8. The antibacterial, breathable and biodegradable medical film material according to claim 5, characterized in that: The initiator includes one or more of benzyl alcohol, 1,4-butanediol, ethylene glycol, glycerol, neopentyl glycol, 2-aminoethanol, triethanolamine, 1,3-propylene glycol, and 1,2-propylene glycol.

9. A method for preparing the antibacterial, breathable and biodegradable medical film material according to any one of claims 1 to 8, characterized in that: include: Premixing the components in the formula to obtain a mixed material, and extruding the mixed material into a film by casting; The barrel temperature is 155-165°C; the filter screen temperature is 175-180°C; the elbow temperature is 175-180°C; the connection temperature is 178-185°C; and the die head temperature is 185-190°C.

10. Use of the antibacterial, breathable and biodegradable medical film material according to any one of claims 1 to 8 in the preparation of medical materials.

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