Binary sanitary fly-killing composition containing cyprosulfuron and application of binary sanitary fly-killing composition

Abstract

The invention discloses a binary sanitary insecticidal composition containing cyprosulfuron and application of the binary sanitary insecticidal composition. The effective components of the binary sanitary insecticidal composition are cyprosulfuron and a neonicotinoid insecticide. The total content of the cyprosulfuron and the neonicotinoid insecticide is 2%-80%; the weight ratio of the cyprosulfuron to the neonicotinoid insecticide is (10: 1)-(1: 20). According to the fly killing composition, two effective components with different action mechanisms are adopted and mixed according to a proper proportion, the action effect is obviously improved compared with that of a single agent, pests can be effectively prevented and controlled, the occurrence of drug resistance is delayed, and in addition, the addition of the attractant composition is innovative.

Description

Technical Field

[0001] The invention relates to a sanitary insecticide composition, in particular to a binary sanitary insecticide composition containing ciprofloxacin and application thereof, wherein the active ingredients of the binary sanitary insecticide composition are ciprofloxacin and neonicotinoid insecticides. Background Art

[0002] For a long time, sanitary insecticides have been mainly pyrethroids, which are mostly used as a single agent or a combination of two pyrethroids to kill sanitary pests. Since its launch, this type of agent has quickly occupied the sanitary insecticide field with its high efficiency and low toxicity, but long-term use has caused some resistance problems.

[0003] Ciprofloxacin is a newly developed compound that has not been used in the health field on the market. It is mainly used for crops. Neonicotinoid insecticides are a class of synthetic nicotinoid compounds that have a killing effect on most pests, mainly through stomach poisoning. The combination of two agents with different mechanisms of action has not been used.

[0004] Residual spraying is a common method of using pesticides in the field of sanitary pest control. Traditional residual spraying relies on the pesticide to remain on the surface of an object to passively kill pests that come into contact with the surface. To this end, traditional residual spraying needs to cover most surfaces that pests may come into contact with, with a large amount of pesticide used and serious pollution. The pesticides that can be selected are limited. By adding some attractants to the residual spray formulation, traditional residual spraying can be changed from passive to active to attract pests to contact or feed on the pesticide. The pesticide coverage area can be changed to partial coverage, reducing the amount of pesticide used and reducing pollution. At the same time, stomach poison-type pesticides can also be used. This method has certain limitations. The short duration of the attractant results in the inability to maintain its advantages. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a binary sanitary insecticide composition containing cyprodinil and its application in view of the deficiencies in the prior art. The present invention solves the passive control situation of residual spraying formulations by adding an attractant composition, and can prolong the lasting effect of the attractant.

[0006] In order to achieve the above object, the present invention adopts the following technical solution:

[0007] The invention first provides a binary sanitary insecticide composition containing ciprofloxacin, wherein the active ingredients are ciprofloxacin and neonicotinoid insecticides, and the total weight of the ciprofloxacin and neonicotinoid insecticides accounts for 2% to 80% of the total weight of the sanitary insecticide composition, and the remainder is auxiliary materials.

[0008] In the above technical scheme, the neonicotinoid insecticide is any one of imidacloprid, acetamiprid, thiacloprid, thiamethoxam, dinotefuran, flupyradone, chlorothiazide, and clothianidin.

[0009] In the above technical solution, the weight ratio of cyfluthrin and neonicotinoid insecticide is 10:1 to 1:20, preferably 1:1 to 1:20.

[0010] In the above technical scheme, the auxiliary materials are auxiliary agents and attractant compositions, wherein the auxiliary agents are a mixture of three or more of wetting agents, dispersants, fillers, antifreeze agents, preservatives, defoamers, thickeners, pH regulators, deionized water, and disintegrants in any proportion.

[0011] In the above technical solution, the binary sanitary insecticide composition is in the form of wettable powder, suspension, water dispersible granules, or dry suspension.

[0012] In the above technical scheme, the binary sanitary insecticide composition, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 1-40% of ciprofloxacin, 1-40% of neonicotinoid insecticide, 2-6% of wetting agent, 7-18% of dispersant, 2-5% of attractant composition, and the remainder is filler.

[0013] In the above technical scheme, the binary sanitary insecticide composition, when in the form of a suspension, comprises the following raw materials in weight percentage: 1-20% of cyfluthrin, 1-20% of neonicotinoid insecticide, 1-8% of wetting agent, 1-20% of dispersant, 3-7% of antifreeze agent, 0.3-2% of preservative, 0.1-1% of defoamer, 0.5-3% of thickener, 0.1-0.5% of pH regulator, 2-5% of attractant composition, and the balance is deionized water.

[0014] In the above technical scheme, the binary sanitary insecticide composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 1-40% of ciprofloxacin, 1-40% of neonicotinoid insecticide, 2-12% of wetting agent, 5-18% of dispersant, 2-8% of disintegrant, 2-5% of attractant composition, and the balance is filler.

[0015] In the above technical scheme, the binary sanitary insecticide composition, when in the form of a dry suspension, comprises the following raw materials in weight percentage: 1-20% of cyfluthrin, 1-40% of neonicotinoid insecticide, 1-8% of wetting agent, 1-8% of dispersant, 2-5% of attractant composition, and the filler is supplemented to 100%.

[0016] In the above technical scheme, the attractant composition comprises the following raw materials in weight percentage: 5% agar, 5% sorbitol, 60% attractant, 5% propylene glycol, 0.5% xanthan gum, 0.5% to 1% magnesium aluminum silicate and the balance deionized water; the attractant is selected from any one of brown sugar, white sugar, cream flavor and cis-9-tricosene.

[0017] In the above technical scheme, the attractant composition is prepared by the following method: agar, sorbitol, attractant, propylene glycol, xanthan gum and water are weighed in proportion, heated to a puffed state, and then 0.5% to 0.7% of magnesium aluminum silicate is added, and stirred evenly to obtain a wet gel-like attractant composition; the same as the above steps, when the amount of magnesium aluminum silicate added is 0.7% to 1%, the attractant composition is naturally dried or baked to obtain a dry gel-like attractant composition.

[0018] In the above technical scheme, the wet gel-like attractant composition is used for suspension and is directly added; the dry gel-like attractant composition is used for wettable powder, water-dispersible granules and dry suspension after being pulverized by air flow.

[0019] In the above technical scheme, the dispersant is selected from any one of modified polyacrylic acid copolymers, modified rosin polyether phosphates, hydrophobic group modified carboxylic acid copolymers, sodium lignin sulfonate, alkyl naphthalene sulfonate sodium salt formaldehyde condensation product, methyl naphthalene sulfonate sodium salt formaldehyde condensation product, alkylphenol polyoxyethylene ether phosphate, phenethylphenol polyoxyethylene ether phosphate, nonionic hydroxy polyethylene oxide block copolymer, fatty alcohol polyoxyethylene ether sodium sulfonate, and fatty alcohol polyoxyethylene ether sodium sulfate, or a mixture of two of them.

[0020] In the above technical scheme, the wetting agent is selected from: sodium polycarboxylate, fatty alcohol polyoxyethylene ether, fatty acid polyoxyethylene ether, fatty amine polyoxyethylene ether, castor oil polyoxyethylene ether, polyarylphenol polyoxyethylene ether (formaldehyde condensate), trisiloxane polyoxyethylene ether, sodium α-olefin sulfonate, alkylbenzene polyoxyethylene ether phosphate, sodium lauryl sulfate, any one or a mixture of two thereof.

[0021] In the above technical solution, the disintegrant is selected from any one of sodium chloride, ammonium sulfate, sodium carbonate, sodium bicarbonate, sodium sulfate, or a mixture of two of them.

[0022] In the above technical solution, the filler is selected from: any one of kaolin, white carbon black, corn starch, attapulgite, calcium carbonate, light calcium, diatomaceous earth, or a mixture of two of them.

[0023] In the above technical solution, the antifreeze agent is any one of ethylene glycol, propylene glycol, glycerin and urea, or a mixture of two of them.

[0024] In the above technical solution, the thickener is any one of xanthan gum, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate, and organic bentonite, or a mixture of two of them.

[0025] In the above technical solution, the preservative is any one of sodium benzoate, potassium sorbate and kasonon or a mixture of two of them.

[0026] In the above technical solution, the defoaming agent is any one of polydimethylsiloxane, silicone oil, and glyceryl ricinoleate, or a mixture of two of them.

[0027] In the above technical solution, the pH regulator is selected from any one of citric acid and benzoic acid.

[0028] In the above technical scheme, when the sanitary insecticide composition is in the form of a suspension, wettable powder, water dispersible granules and dry suspension, it can be prepared according to conventional methods or existing methods in the art.

[0029] The invention provides an application of the binary sanitary insecticide composition containing cyprodinil in the field of sanitation for preventing and controlling flies.

[0030] In the above technical scheme, the flies include flies of the Muscidae family and Calliphoridae family, specifically: housefly, city fly, summer toilet fly, toilet fly, stable fly, big-headed golden fly, silk-colored green fly, copper green fly, bright green fly, red-headed blowfly, giant-tailed Ali fly, bedfly, and new land bedfly.

[0031] In the above technical scheme, when the binary sanitary insecticide composition containing cyprodinil is used to control flies in the sanitary field, the insecticide composition is diluted 50-200 times with water through residual spraying control, and the liquid medicine is sprayed on the ground, wall, railing, fence surface, etc. using a constant spray equipment.

[0032] Compared with the existing technology, it has the following characteristics:

[0033] The binary sanitary insecticide composition of the present invention has a good control effect on sanitary pests resistant to pyrethroid insecticides, thereby improving the control effect; the combination of the two insecticides with different action mechanisms can also delay the generation of resistance, thus providing a new method for controlling sanitary pests and delaying resistance; the addition of the attractant composition greatly improves the killing effect of the composition on flies and reduces the irritation to non-target animals. DETAILED DESCRIPTION

[0034] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0035] In the following embodiments of the present invention, the attractant composition is prepared by the following method:

[0036] (1) Weigh 5 g agar, 0.5 g xanthan gum, 0.5 g aluminum magnesium silicate, and 24 g water, and heat until the agar and xanthan gum swell;

[0037] (2) Weigh 60 g of attractant, 5 g of sorbitol, and 5 g of propylene glycol, add them to the solution of step (1), stir evenly, and obtain a wet gel-like attractant composition, which is used for the suspension and added directly;

[0038] (3) Repeat steps (1) and (2) except that the amount of magnesium aluminum silicate added is adjusted to 1 g and the amount of water is adjusted to 23.5 g. The obtained gel is dried by self-heating to form a dry gel-like attractant composition, which is then crushed by air flow to be used in wettable powders, water dispersible granules, and dry suspensions.

[0039] In the following embodiments of the present invention, the preparation methods of various dosage forms are as follows:

[0040] The laboratory preparation method of wettable powder is as follows: add cyflumizone, neonicotinoid insecticide, wetting agent, dispersant, attractant composition and filler into a food processor and mix them evenly, and then put them into a jet mill for crushing to obtain the wettable powder.

[0041] The laboratory preparation method of the suspension concentrate is as follows: weigh the wetting agent, dispersant, antifreeze agent, preservative, defoamer, pH regulator, attractant composition and deionized water according to the proportion, add them into a beaker and mix them evenly, then add cyprodinil and neonicotinoid insecticides into the beaker, and then transfer it to a sand mill, add zirconium oxide beads into the sand mill, grind for 2-3 hours, add thickener and continue grinding for 0.5 hours, and make the particle size D 95 The product can be obtained by controlling the particle size below 5 microns and filtering to remove the zirconium oxide beads.

[0042] The laboratory preparation method of water-dispersible granules is as follows: add ciprofloxacin, neonicotinoid insecticides, wetting agents, dispersants, disintegrants, attractant compositions, and fillers into a food processor and mix them evenly, then put them into a jet mill for grinding, mix them again with a food processor, add an appropriate amount of deionized water, extrude and granulate them with a granulator, and then dry them at 54°C for 2 hours to obtain the water-dispersible granules.

[0043] The laboratory preparation method of the dry suspension is as follows: weigh the wetting agent, dispersant, attractant composition, filler and deionized water according to the proportion, add them into a beaker and mix them evenly, then add cyprodinil and neonicotinoid insecticides into the beaker, and then transfer it to a sand mill, add zirconium oxide beads into the sand mill, grind for 2-3 hours, and make the particle size D 95 The particle size is controlled below 5 microns, the zirconium oxide beads are removed by filtration, and the obtained material is dried by a spray dryer to obtain the product.

[0044] The present invention will be described below in conjunction with specific embodiments:

[0045] Formulation Example 1: 16% cyprodinil·imidacloprid suspension

[0046] 8g of cyprodinilflumizone, 8g of imidacloprid, 4g of sodium polycarboxylate, 5g of modified polyacrylic acid copolymer, 5g of propylene glycol, 0.5g of potassium sorbate, 0.1g of citric acid, 0.5g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of silicone oil, 2g of attractant composition (attractant brown sugar), and deionized water to make up to 100g. A suspension was prepared according to the above method.

[0047] Formulation Example 2: 5% cyprodinil·thiacloprid suspension

[0048] 1g of cyprodinil, 4g of thiacloprid, 5g of sodium polycarboxylate, 2g of fatty alcohol polyoxyethylene ether, 4g of modified rosin polyether phosphate, 2g of sodium lignin sulfonate, 3g of urea, 0.5g of potassium sorbate, 0.5g of magnesium aluminum silicate, 0.4g of xanthan gum, 0.2g of polydimethylsiloxane, 0.2g of benzoic acid, 2g of attractant composition (attractant white sugar), and deionized water to make up to 100g. The suspension was prepared according to the above method.

[0049] Formulation Example 3: 30% cyprodinil·acetamiprid suspension

[0050] 10g of cyprodinil, 20g of acetamiprid, 8g of alkylbenzene polyoxyethylene ether phosphate, 2g of sodium lignin sulfonate, 3g of alkylphenol polyoxyethylene ether phosphate, 7g of ethylene glycol, 0.3g of potassium sorbate, 0.25g of magnesium aluminum silicate, 0.25g of xanthan gum, 0.2g of glycerol ricinoleate, 0.3g of citric acid, 5g of attractant composition (attractant cream flavor), and deionized water are added to 100g. The suspension is prepared according to the above method.

[0051] Formulation Example 4: 5% cyprodinil·thiamethoxam suspension

[0052] 2.5g of cyprosulfuron, 2.5g of thiamethoxam, 2g of fatty alcohol polyoxyethylene ether, 5g of modified rosin polyether phosphate, 5g of sodium lauryl sulfate, 5g of sodium lignin sulfonate, 5g of nonionic hydroxy polyethylene oxide block copolymer, 7g of glycerol, 2g of sodium benzoate, 2.6g of magnesium aluminum silicate, 0.4g of xanthan gum, 1g of glycerol ricinoleate, 2g of attractant composition (attractant cis-9-tricosene), 0.5g of citric acid, and deionized water are added to make up to 100g. The suspension is prepared according to the above method.

[0053] Formulation Example 5: 15% cyprodinil·dinotefuran suspension

[0054] 5g of cyprodinil, 10g of dinotefuran, 7g of fatty acid polyoxyethylene ether, 1g of sodium fatty alcohol polyoxyethylene ether sulfonate, 7g of propylene glycol, 0.3g of potassium sorbate, 0.3g of citric acid, 1g of magnesium aluminum silicate, 0.4g of xanthan gum, 1g of glycerol ricinoleate, 3g of attractant composition (attractant brown sugar), and deionized water are added to 100g. A suspension is prepared according to the above method.

[0055] Formulation Example 6: 2% cyprodinil flupyradone suspension

[0056] Cyclosulfuron 1g, flupyrrolidone 1g, hydrophobic group modified carboxylic acid copolymer 7g, methyl naphthalene sulfonic acid sodium salt formaldehyde condensate 1g, fatty alcohol polyoxyethylene ether sodium sulfate 1g, α-olefin sulfonate sodium 1g, propylene glycol 5g, kason 1.8g, citric acid 0.5g, magnesium aluminum silicate 2g, xanthan gum 0.4g, silicone oil 0.5g, attractant composition (attractant cis-9-tricosene) 2g, deionized water is added to 100g. The suspension is prepared according to the above method.

[0057] Formulation Example 7: 10% cyprodinil·chlorothiazide suspension

[0058] 2g of cyprodinil, 8g of chlorpyrifos, 7g of sodium sulfate of fatty alcohol polyoxyethylene ether, 4g of fatty amine polyoxyethylene ether, 5g of propylene glycol, 2g of potassium sorbate, 0.4g of citric acid, 2g of magnesium aluminum silicate, 0.4g of xanthan gum, 0.5g of silicone oil, 3g of attractant composition (attractant cis-9-tricosene), and deionized water are added to 100g. A suspension is prepared according to the above method.

[0059] Formulation Example 8: 40% cyprodinil fluazifop-thiamethoxam suspension

[0060] 20g of cyprofensulfuron, 20g of clothianidin, 2g of phenethylphenol polyoxyethylene ether phosphate, 2g of hydrophobic group modified carboxylic acid copolymer, 4g of castor oil polyoxyethylene ether, 5g of propylene glycol, 2g of kason, 0.1g of citric acid, 2g of magnesium aluminum silicate, 0.4g of xanthan gum, 0.5g of silicone oil, 5g of attractant composition (attractant cis-9-tricosene), and deionized water are added to 100g. A suspension is prepared according to the above method.

[0061] Formulation Example 9: 30% cyprodinil·acetamiprid wettable powder

[0062] Cyprodinil 10g, acetamiprid 20g, sodium lignin sulfonate 8g, alkylnaphthalene sulfonic acid sodium salt formaldehyde condensation product 10g, sodium dodecyl sulfate 2g, attractant composition (attractant cis-9-tricosene) 4g, kaolin is supplemented to 100g. Wettable powder is prepared according to the above method.

[0063] Formulation Example 10: 80% cyprodinil·dinotefuran wettable powder

[0064] 40g of cyprodinil, 40g of dinotefuran, 10g of sodium lignin sulfonate, 5g of sodium lauryl sulfate, 2g of attractant composition (attractant brown sugar), and kaolin to make up to 100g. A wettable powder was prepared according to the above method.

[0065] Formulation Example 11: 4% cyprodinil·imidacloprid wettable powder

[0066] 1g of cyprofenamide, 3g of imidacloprid, 7g of methylnaphthalenesulfonic acid sodium salt formaldehyde condensate, 6g of sodium dodecyl sulfate, 3.8g of attractant composition (attractant cis-9-tricosene), and kaolin to make up to 100g. A wettable powder was prepared according to the above method.

[0067] Formulation Example 12: 5% cyprodinil·thiacloprid wettable powder

[0068] 2.5 g of cyprodinil, 2.5 g of thiacloprid, 10 g of sodium lignin sulfonate, 6 g of sodium dodecyl sulfate, 3.8 g of attractant composition (attractant cis-9-tricosene), and kaolin to make up to 100 g. A wettable powder was prepared according to the above method.

[0069] Formulation Example 13: 25% cyprodinil·thiamethoxam wettable powder

[0070] 5 g of cyprodinil, 20 g of thiamethoxam, 10 g of sodium lignin sulfonate, 4 g of sodium dodecyl sulfate, 3.8 g of attractant composition (attractant cis-9-tricosene), and kaolin to make up to 100 g. A wettable powder was prepared according to the above method.

[0071] Formulation Example 14: 42% cyprodinil·flupyrazone wettable powder

[0072] 2g of cyprodinil, 40g of flupyralidone, 12g of sodium lignin sulfonate, 5g of sodium dodecyl sulfate, 5g of attractant composition (attractant cis-9-tricosene), and kaolin to make up to 100g. A wettable powder was prepared according to the above method.

[0073] Formulation Example 15: 15% cyprodinil·chlorothiazide wettable powder

[0074] 5g of cyprodinil, 10g of chlorpyrifos, 18g of sodium salt of methylnaphthalene sulfonate formaldehyde condensate, 6g of sodium dodecyl sulfate, 3.8g of attractant composition (attractant cis-9-tricosene), and kaolin to make up to 100g. A wettable powder was prepared according to the above method.

[0075] Formulation Example 16: 35% cyprodinil·thiamethoxam wettable powder

[0076] 5g of cyprodinil, 30g of clothianidin, 12g of sodium lignin sulfonate, 4g of sodium dodecyl sulfate, 4g of attractant composition (attractant cis-9-tricosene), and kaolin to make up to 100g. A wettable powder was prepared according to the above method.

[0077] Formulation Example 17: 60% cyprodinil·dinotefuran water dispersible granules

[0078] 20g of cyfluthrin, 40g of dinotefuran, 5g of sodium lignin sulfonate, 5g of sodium polycarboxylate, 1g of sodium sulfate, 3g of ammonium sulfate, 5g of attractant composition (attractant cis-9-tricosene), and corn starch to make up to 100g. Water dispersible granules were prepared according to the above method.

[0079] Formulation Example 18: 20% cyprodinil·imidacloprid water dispersible granules

[0080] 5g of cyprodinil, 15g of imidacloprid, 5g of sodium lignin sulfonate, 12g of sodium polycarboxylate, 1g of sodium sulfate, 1g of ammonium sulfate, 2g of attractant composition (attractant cream flavor), 6g of light calcium, and diatomaceous earth are added to make up to 100g. Water dispersible granules are prepared according to the above method.

[0081] Formulation Example 19: 30% cyprodinil·acetamiprid water dispersible granules

[0082] Cyprodinil 10g, acetamiprid 20g, sodium lignin sulfonate 8g, sodium polycarboxylate 2g, sodium carbonate 4g, sodium bicarbonate 4g, attractant composition (attractant cis-9-tricosene) 3g, kaolin is added to make up to 100g. Water dispersible granules are prepared according to the above method.

[0083] Formulation Example 20: 25% cyprodinil·thiacloprid water dispersible granules

[0084] 5g of cyprodinil, 20g of thiacloprid, 8g of sodium lignin sulfonate, 5g of sodium polycarboxylate, 2g of sodium carbonate, 2g of sodium bicarbonate, 4g of attractant composition (attractant cis-9-tricosene), and diatomaceous earth are added to make up to 100g. Water dispersible granules are prepared according to the above method.

[0085] Formulation Example 21: 40% cyprodinil·thiamethoxam water dispersible granules

[0086] 20g of cyprofensulfuron, 20g of thiamethoxam, 5g of methylnaphthalenesulfonic acid sodium salt formaldehyde condensate, 5g of sodium polycarboxylate, 6g of sodium chloride, 5g of attractant composition (attractant cis-9-tricosene), 5g of calcium carbonate, and corn starch to make up to 100g. Water dispersible granules were prepared according to the above method.

[0087] Formulation Example 22: 30% cyprodinil·flupyrazone water dispersible granules

[0088] 5g of cyprofenamide, 25g of flupyralidone, 4g of alkylnaphthalenesulfonic acid sodium salt formaldehyde condensate, 4g of methylnaphthalenesulfonic acid sodium salt formaldehyde condensate, 10g of sodium polycarboxylate, 6g of sodium chloride, 5g of attractant composition (attractant cis-9-tricosene), 4g of light calcium, and attapulgite to make up to 100g. Water dispersible granules were prepared according to the above method.

[0089] Formulation Example 23: 20% ciprofloxacin·chlorothiazide water dispersible granules

[0090] 15g of cyprodinil, 5g of chlorpyrifos, 6g of sodium lignin sulfonate, 10g of fatty amine polyoxyethylene ether, 6g of sodium chloride, 3.8g of attractant composition (attractant cis-9-tricosene), 4g of light calcium, and attapulgite are added to make up to 100g. Water dispersible granules are prepared according to the above method.

[0091] Formulation Example 24: 25% cyprodinil·thiamethoxam water dispersible granules

[0092] 5g of cyprodinil, 20g of clothianidin, 6g of sodium lignin sulfonate, 10g of fatty alcohol polyoxyethylene ether, 6g of sodium chloride, 3.8g of attractant composition (attractant cis-9-tricosene), 4g of light calcium, and attapulgite are added to make up to 100g. Water dispersible granules are prepared according to the above method.

[0093] Formulation Example 25: 60% cyprodinil·dinotefuran dry suspension

[0094] 20g of cyfluthrin, 40g of dinotefuran, 5g of sodium lignin sulfonate, 5g of sodium polycarboxylate, 5g of attractant composition (attractant brown sugar), and corn starch to make up to 100g. A dry suspension was prepared according to the above method.

[0095] Formulation Example 26: 20% cyprodinil·imidacloprid dry suspension

[0096] 5g of cyprodinil, 15g of dinotefuran, 2.5g of sodium lignin sulfonate, 8g of sodium polycarboxylate, 3g of attractant composition (attractant cis-9-tricosene), 6g of light calcium, and diatomaceous earth are added to make up to 100g. A dry suspension is prepared according to the above method.

[0097] Formulation Example 27: 30% cyprodinil·acetamiprid dry suspension

[0098] Cyprodinil 10g, acetamiprid 20g, sodium lignin sulfonate 8g, sodium polycarboxylate 2g, attractant composition (attractant cis-9-tricosene) 4g, kaolin is added to make up to 100g. A dry suspension is prepared according to the above method.

[0099] Formulation Example 28: 25% cyprodinil·thiacloprid dry suspension

[0100] 5g of cyprodinil, 20g of thiacloprid, 8g of sodium lignin sulfonate, 5g of sodium polycarboxylate, 3g of attractant composition (attractant cis-9-tricosene), and diatomaceous earth are added to make up to 100g. A dry suspension is prepared according to the above method.

[0101] Formulation Example 29: 40% cyprodinil·thiamethoxam dry suspension

[0102] Cyprodinil flumet 20g, thiamethoxam 20g, methylnaphthalene sulfonic acid sodium salt formaldehyde condensate 4g, sodium polycarboxylate 5g, attractant composition (attractant cis-9-tricosene) 4g, calcium carbonate 5g, corn starch is supplemented to 100g. A dry suspension is prepared according to the above method.

[0103] Formulation Example 30: 30% cyprodinil flupyradone dry suspension

[0104] 5g of cyprofenamide, 25g of flupyralidone, 4g of alkylnaphthalenesulfonic acid sodium salt formaldehyde condensate, 4g of methylnaphthalenesulfonic acid sodium salt formaldehyde condensate, 8g of sodium polycarboxylate, 5g of attractant composition (attractant cis-9-tricosene), 4g of light calcium, and attapulgite to make up to 100g. A dry suspension was prepared according to the above method.

[0105] Formulation Example 31: 20% cyprodinil·chlorothiazide dry suspension

[0106] 15g of cyprodinil, 5g of chlorpyrifos, 6g of sodium lignin sulfonate, 4g of fatty amine polyoxyethylene ether, 2g of attractant composition (attractant cis-9-tricosene), 4g of light calcium, and attapulgite are added to make up to 100g. A dry suspension is prepared according to the above method.

[0107] Formulation Example 32: 25% cyprodinil·thiamethoxam dry suspension

[0108] 5g of cyprodinil, 20g of clothianidin, 6g of sodium lignin sulfonate, 5g of fatty alcohol polyoxyethylene ether, 3g of attractant composition (attractant cis-9-tricosene), 4g of light calcium, and attapulgite are added to make up to 100g. A dry suspension is prepared according to the above method.

[0109] Comparative Example 1: 8% cyprodinil suspension

[0110] 8g of cyprodinilflumizone, 4g of sodium polycarboxylate, 5g of modified rosin polyether phosphate, 5g of propylene glycol, 0.5g of potassium sorbate, 0.1g of citric acid, 0.5g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of silicone oil, 2g of attractant composition (attractant brown sugar), and deionized water to make up to 100g. A suspension was prepared according to the above method.

[0111] Comparative Example 2: 40% dinotefuran wettable powder

[0112] 40g of dinotefuran, 10g of sodium lignin sulfonate, 5g of sodium dodecyl sulfate, 2g of attractant composition (attractant brown sugar), and kaolin to make up to 100g. A wettable powder was prepared according to the above method.

[0113] Comparative Example 3: 15% Imidacloprid Water Dispersible Granules

[0114] Imidacloprid 15g, sodium lignin sulfonate 5g, sodium polycarboxylate 12g, sodium sulfate 1g, ammonium sulfate 1g, light calcium 6g, attractant composition (attractant cream flavor) 2g, diatomaceous earth is added to make up to 100g. Water dispersible granules are prepared according to the above method.

[0115] Comparative Example 4: 40% Dinotefuran dry suspension

[0116] 40g of dinotefuran, 5g of sodium lignin sulfonate, 5g of sodium polycarboxylate, 5g of attractant composition (attractant brown sugar), and corn starch are added to make up to 100g. A dry suspension is prepared according to the above method.

[0117] Comparative Example 5: 15% cyprodinil·dinotefuran suspension

[0118] 5g of cyprodinil, 10g of dinotefuran, 7g of fatty acid polyoxyethylene ether, 1g of sodium fatty alcohol polyoxyethylene ether sulfonate, 7g of propylene glycol, 0.3g of potassium sorbate, 0.3g of citric acid, 1g of magnesium aluminum silicate, 0.4g of xanthan gum, 1g of glycerol ricinoleate, and deionized water are added to make up to 100g. A suspension was prepared according to the above method.

[0119] Comparative Example 6: 80% cyprodinil·dinotefuran wettable powder

[0120] 40g of cyprodinil, 40g of dinotefuran, 10g of sodium lignin sulfonate, 5g of sodium lauryl sulfate, and kaolin are added to make up to 100g. Wettable powder is prepared according to the above method.

[0121] Comparative Example 7: 20% cyprodinil·imidacloprid water dispersible granules

[0122] 5g of cyprodinil, 15g of imidacloprid, 5g of sodium lignin sulfonate, 12g of sodium polycarboxylate, 1g of sodium sulfate, 1g of ammonium sulfate, 6g of light calcium, and diatomaceous earth are added to make up to 100g. Water dispersible granules are prepared according to the above method.

[0123] The technical effects of the present invention are described below in conjunction with specific experiments:

[0124] Verification test 1: Co-toxicity coefficient test

[0125] (1) Test subjects: Houseflies (reared in the laboratory)

[0126] (2) Test method: Refer to GB / T26350-2010 "Methods for detecting insecticide resistance in flies - Housefly bioassay" and NY / T1154.7-2006 "Guidelines for indoor bioassay of pesticides - Insecticides - Part 7: Determination of the combined effect of mixtures"

[0127] (3) Data statistics: Take the drug to be tested and dissolve it in dichloromethane first, then use an aqueous solution containing 0.1% Triton-X100 to perform a series of dilutions at a ratio of 1:9, take 1mL of each diluted concentration and add it to a 150mL serum bottle, keep rotating the serum bottle to make the drug solution evenly distributed on the inner wall of the bottle, place it in a fume hood overnight to allow the organic solvent to evaporate completely, and then put the test insects in to determine the concentration range of the drug that causes 100% death and 100% survival. Take the appropriate concentration within this range and use an aqueous solution containing 0.1% Triton-X100 to perform a series of multiple dilutions. Take 1mL of each diluted concentration and add it to a 150mL serum bottle, keep rotating the serum bottle to make the drug solution evenly distributed on the inner wall of the bottle, place it in a fume hood overnight to allow the organic solvent to evaporate completely. Then apply vaseline on the bottleneck of the serum bottle, put 20 test insects in each bottle, and repeat the experiment 5 times. The corresponding solvent treatment is used as the control group. After 1 hour, all test insects were transferred to clean containers for standard feeding. After 24 hours, the number of deaths was checked and counted. The statistical analysis software SPSS was used for analysis to calculate the LC of each agent. 50 and its 95% confidence limit. The results are shown in the following table:

[0128] Table 1 Co-toxicity coefficient of cyfluthrin and imidacloprid to housefly

[0129]

[0130]

[0131] It can be seen from Table 1 that when the combination ratio of ciprofloxacin: imidacloprid is between 10:1 and 2:1, the co-toxicity coefficient to houseflies is greater than 100 and less than 120, showing an additive effect; when the combination ratio of ciprofloxacin: imidacloprid is between 1:1 and 1:20, the co-toxicity coefficient to houseflies is greater than 120, and the synergistic effect is obvious.

[0132] Table 2 Co-toxicity coefficient of cyprodinil and dinotefuran to houseflies

[0133]

[0134] It can be seen from Table 2 that when the combination ratio of ciprofloxacin: dinotefuran is between 10:1 and 2:1, the co-toxicity coefficient to houseflies is greater than 100 and less than 120, showing an additive effect; when the combination ratio of ciprofloxacin: dinotefuran is between 1:1 and 1:20, the co-toxicity coefficient to houseflies is greater than 120, and the synergistic effect is obvious.

[0135] The optimal proportions and co-toxicity coefficients of ciprofloxacin and acetamiprid, thiacloprid, thiamethoxam, flupyralid, chlorothiazide and clothianidin are shown in Table 3 below:

[0136] Table 3 Co-toxicity coefficients of cyfluthrin and neonicotinoid insecticides to houseflies

[0137]

[0138] Verification test 2: Fly retention efficacy test

[0139] (1) Test subjects: Housefly

[0140] (2) Test method: Refer to GB / T13917.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spraying test.

[0141] (3) Test agent:

[0142] Comparative Example 1: 70% Imidacloprid water dispersible granules (commercially available)

[0143] Comparative Example 2: 40% dinotefuran soluble granules (commercially available)

[0144] Preparation Examples 1 to 35 were all diluted with water to 800 ppm, Comparative Examples 1 to 4 and Control Examples 1 to 2 were diluted with water to 800 ppm.

[0145] (4) Statistics:

[0146] Table 4 Results of efficacy tests of several treatments against houseflies

[0147]

[0148]

[0149] The test results show that the mortality rate of the optimally formulated compound pesticide against houseflies is 80% to 100%, and the effect is obvious.

[0150] Verification test 3: Attractant effect test of attractant composition

[0151] (1) Test subjects: Housefly

[0152] (2) Test method: Refer to GB / T13917.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spraying test.

[0153] (3) Test agent:

[0154] Comparative Examples 5, 6, and 7 were all diluted with water to 800 ppm, and Formulation Examples 5, 10, and 18 were diluted with water to 800 ppm.

[0155] (4) Statistics:

[0156] Table 5 Results of efficacy tests of several treatments against houseflies

[0157] Treatment Group Target 24-hour mortality rate Preparation Example 5 Housefly 90.0％ Comparative Example 5 Housefly 76.7％ Preparation Example 10 Housefly 96.7％ Comparative Example 6 Housefly 86.7％ Preparation Example 18 Housefly 100.0％ Comparative Example 7 Housefly 83.3％

[0158] The test results show that the mortality rate of the agent with the attractant composition added is higher than that of the agent without the attractant composition added.

[0159] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A binary sanitary insecticide composition containing cyprodinil, characterized in that: The active ingredients are ciprofloxacin and neonicotinoid insecticides, and the total weight of ciprofloxacin and neonicotinoid insecticides accounts for 2% to 80% of the total weight of the sanitary insecticide composition, and the remainder is auxiliary materials; The neonicotinoid insecticide is any one of imidacloprid, acetamiprid, thiacloprid, thiamethoxam, dinotefuran, flupyradone, chlorothiazide and clothianidin; the weight ratio of cyprodinil to the neonicotinoid insecticide is 10:1 to 1:

20.

2. The binary sanitary insecticide composition according to claim 1, characterized in that: The auxiliary materials are auxiliary agents and attractant compositions, wherein the auxiliary agents are a mixture of three or more of wetting agents, dispersants, fillers, antifreeze agents, preservatives, defoamers, thickeners, pH regulators, deionized water, and disintegrants in any proportion; the binary sanitary insecticide composition is in the form of wettable powders, suspensions, water-dispersible granules, and dry suspensions.

3. The binary sanitary insecticide composition according to claim 2, characterized in that: The binary sanitary insecticide composition, when in the form of a wettable powder, comprises the following raw materials in percentage by weight: 1-40% of cyfluthrin, 1-40% of a neonicotinoid insecticide, 2-6% of a wetting agent, 7-18% of a dispersant, 2-5% of an attractant composition, and the remainder being filler.

4. The binary sanitary insecticide composition according to claim 2, characterized in that: The binary sanitary insecticide composition, when in the form of a suspension, comprises the following raw materials in percentage by weight: 1-20% of ciprofloxacin, 1-20% of neonicotinoid insecticide, 1-8% of a wetting agent, 1-20% of a dispersant, 3-7% of an antifreeze agent, 0.3-2% of a preservative, 0.1-1% of a defoamer, 0.5-3% of a thickener, 0.1-0.5% of a pH regulator, 2-5% of an attractant composition, and the remainder is deionized water.

5. The binary sanitary insecticide composition according to claim 2, characterized in that: The binary sanitary insecticide composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 1-40% of ciprofloxacin, 1-40% of neonicotinoid insecticide, 2-12% of wetting agent, 5-18% of dispersant, 2-8% of disintegrant, 2-5% of attractant composition, and the balance is filler.

6. The binary sanitary insecticide composition according to claim 2, characterized in that: The binary sanitary insecticide composition, when in the form of a dry suspension, comprises the following raw materials in weight percentage: 1-20% of component A, 1-40% of component B, 1-8% of a wetting agent, 1-8% of a dispersant, 2-5% of an attractant composition, and the filler is supplemented to 100%.

7. The binary sanitary insecticide composition according to any one of claims 3 to 6, characterized in that: The attractant composition comprises the following raw materials in weight percentage: 5% agar, 5% sorbitol, 60% attractant, 5% propylene glycol, 0.5% xanthan gum, 0.5% to 1% magnesium aluminum silicate and the balance deionized water; the attractant is selected from any one of brown sugar, white granulated sugar, cream flavor and cis-9-tricosene.

8. The binary sanitary insecticide composition according to claim 7, characterized in that: The attractant composition is prepared by the following method: agar, sorbitol, attractant, propylene glycol, xanthan gum and water are weighed in proportion, heated to a puffed state, and then 0.5% of magnesium aluminum silicate is added, and stirred evenly to obtain a wet gel-like attractant composition; the same as the above steps, when the amount of magnesium aluminum silicate added is 1%, the dry gel-like attractant composition is obtained by natural air drying or baking; the wet gel-like attractant composition is used for a suspension and is directly added; the dry gel-like attractant composition is used for a wettable powder, a water-dispersible granule, and a dry suspension after being pulverized by air flow.

9. Use of the binary sanitary insecticide composition containing cyfluthrin as claimed in claim 1 in controlling flies in the sanitary field.

10. The use according to claim 9, characterized in that: The flies mentioned herein refer to: houseflies, city flies, summer toilet flies, toilet flies, stable flies, big-headed golden flies, silky green flies, copper green flies, bright green flies, red-headed blowflies, giant-tailed Ali flies, bedflies, and new land bedflies.

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