Composition for delaying oxidation of phenolic hydroxyl compound

Abstract

The invention discloses a composition for delaying oxidation of a phenolic hydroxyl compound, which comprises a protective agent, a stabilizer and a protective agent, and the mass ratio of the protective agent to the stabilizer to the protective agent is (0.01-0.3): (0.01-3): (0.005-5). According to the composition for delaying oxidation of the phenolic hydroxyl compound, hydroxyl in the phenolic hydroxyl compound is influenced by a benzene ring, so that the activity is enhanced, and the phenolic hydroxyl compound is easily oxidized into quinones with different colors. The composition comprises a protective agent, a stabilizer and a protective agent which can form a triple protective cover to delay the oxidation of the phenolic hydroxyl compound. Wherein the protective agent can be complexed with metal ions to reduce the catalytic action of trace iron or other heavy metals in the system on the oxidation reaction, so that the generation rate of free radicals is reduced; hydrogen bonds are formed between the stabilizer and the phenolic hydroxyl compound, so that the probability that the phenolic hydroxyl group is attacked by free radicals is reduced, and the oxidation reaction of the phenolic hydroxyl compound is delayed; the protective agent has a certain electron donor capability and is competitively combined with free radicals, so that the free radicals become relatively stable, attack of the free radicals on phenolic hydroxyl groups is interrupted, oxidation reaction is inhibited, the thermal stability of phenolic hydroxyl compounds is greatly improved, and discoloration reaction is delayed.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetics, and in particular to a composition for delaying the oxidation of phenolic hydroxyl compounds. Background Art

[0002] Raw materials containing phenolic hydroxyl groups have very important application value in the fields of food, medicine, and cosmetics. They have multiple functions such as antioxidant, anti-inflammatory, and anti-aging. However, the hydroxyl group in phenolic hydroxyl groups is affected by the benzene ring, and its activity is enhanced. It is easily oxidized into quinones of different colors and has poor stability. Summary of the invention

[0003] In order to solve the above problems, the present application provides a composition that can delay the oxidation of phenolic hydroxyl compounds and improve the stability of phenolic hydroxyl compounds.

[0004] The present application provides a composition for delaying the oxidation of phenolic hydroxyl compounds, which includes a protective agent, a stabilizer and a protective agent, wherein the mass ratio of the protective agent, the stabilizer and the protective agent is (0.01-0.3): (0.01-3): (0.005-5).

[0005] Furthermore, the protective agent is EDTA-2Na or EDTA-2K.

[0006] Furthermore, the stabilizer is selected from one or more of inositol, erythritol, trehalose, xylitol, sorbitol, glucose, rhamnose, fructose, galactose, fucose, maltose, soluble proteoglycan, and ginseng polysaccharide.

[0007] Furthermore, the protective agent is one or more of ergothioneine, acetylhydroxyproline, and raspberry glycosides.

[0008] Further, the phenolic hydroxy compound is selected from one or more of phenethyl resorcinol, 4-butyl resorcinol, hexyl resorcinol, n-octyl resorcinol, 4-pentyl resorcinol, 4-propyl resorcinol, 2-n-propyl resorcinol, 2-methyl resorcinol, 4-benzyl-1,3-benzene, 5-undecyl resorcinol, 4-methyl resorcinol, isopropyl catechol, 4-butyl catechol, 3-butyl catechol, 3-methyl catechol, 3-ethoxy catechol, resveratrol, pterostilbene, 3'-hydroxypterostilbene, resveratrol-4'-methyl ether, and dihydro-resveratrol.

[0009] The present application also provides a use of the aforementioned composition for delaying the oxidation of phenolic hydroxyl compounds in delaying the oxidation of phenolic hydroxyl compounds.

[0010] The present application provides a composition, which includes a phenolic hydroxyl compound and the aforementioned composition for delaying the oxidation of the phenolic hydroxyl compound.

[0011] Furthermore, the phenolic hydroxy compound is dissolved in water to form a phenolic hydroxy compound system, and the mass ratio of the phenolic hydroxy compound system to the protective agent, stabilizer and protectant is 80: (0.01-0.3): (0.01-3): (0.005-5).

[0012] Furthermore, the phenolic hydroxy compound is a water-insoluble compound, and the phenolic hydroxy compound system also includes a solubilizing agent. The mass ratio of the phenolic hydroxy compound, the solubilizing agent and water is (0.001-1): (0.01-10): (0.01-18).

[0013] Furthermore, the solubilizing agent is selected from one or more of betaine, dipropylene glycol, dimethyl isosorbide, trimethylpentanediol / adipic acid / glycerol cross-linked polymer or PEG / PPG-17 / 6 copolymer.

[0014] Furthermore, the solubilizing agent is a combination of betaine and dipropylene glycol, and the mass ratio of the betaine to dipropylene glycol is (0.5-10):1.

[0015] The present application provides a composition for delaying the oxidation of a phenolic hydroxyl compound or use of the aforementioned composition in cosmetics.

[0016] The composition for delaying the oxidation of phenolic hydroxyl compounds of the present application, because the hydroxyl group in the phenolic hydroxyl compound is affected by the benzene ring, the activity is enhanced, and it is easy to be oxidized into quinones of different colors. The composition described in the present application includes a protective agent, a stabilizer and a protective agent, which can form a triple protective shield to delay the oxidation of phenolic hydroxyl compounds. Wherein the protective agent can complex metal ions, reduce the catalytic effect of trace iron or other heavy metals present in the system on the oxidation reaction, thereby reducing the generation rate of free radicals; hydrogen bonds are formed between the stabilizer and the phenolic hydroxyl compound, reducing the probability of the phenolic hydroxyl group being attacked by free radicals, and delaying the oxidation reaction of the phenolic hydroxyl compound; the protective agent has a certain electron donor ability, competitively combines with free radicals, and makes the free radicals become relatively stable, thereby interrupting the attack of free radicals on the phenolic hydroxyl group, inhibiting the oxidation reaction, thereby greatly improving the thermal stability of the phenolic hydroxyl compound and delaying the color change reaction. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The accompanying drawings are used to better understand the present application and do not constitute an improper limitation on the present application.

[0018] Figure 1 This is a color comparison of the compositions of the examples of the present application and the comparative examples after being placed for 50 days. DETAILED DESCRIPTION

[0019] The following is a description of the exemplary embodiments of the present application, including various details of the embodiments of the present application to facilitate understanding, which should be considered as merely exemplary. Therefore, it should be recognized by those of ordinary skill in the art that various changes and modifications can be made to the embodiments described herein without departing from the scope and spirit of the present application. Similarly, for the sake of clarity and conciseness, the description of well-known functions and structures is omitted in the following description.

[0020] The present application provides a composition for delaying the oxidation of phenolic hydroxyl compounds, comprising a protective agent, a stabilizer and a protective agent, wherein the mass ratio of the protective agent, the stabilizer and the protective agent is (0.01-0.3): (0.01-3): (0.005-5), preferably (0.05-0.25): (0.1-1): (0.1-2.5).

[0021] The composition of the application includes a protective agent, a stabilizer and a protective agent, which can form a triple protective shield to delay the oxidation of phenolic hydroxyl compounds. The protective agent can complex metal ions and reduce the catalytic effect of trace iron or other heavy metals in the system on the oxidation reaction, thereby reducing the rate of free radical generation; hydrogen bonds are formed between the stabilizer and the phenolic hydroxyl compound, reducing the probability of phenolic hydroxyl being attacked by free radicals and delaying the oxidation reaction of the phenolic hydroxyl compound; the protective agent has a certain electron donor ability and competitively combines with free radicals to make the free radicals relatively stable, thereby interrupting the attack of free radicals on phenolic hydroxyl groups and inhibiting the oxidation reaction, thereby greatly improving the thermal stability of phenolic hydroxyl compounds and delaying the discoloration reaction.

[0022] In some embodiments, the mass ratio of the protective agent to the stabilizer is (0.05-0.25):

[0023] (0.1-1).

[0024] In some embodiments, the mass ratio of the protective agent to the stabilizer is 0.05:(0.1-1).

[0025] In some embodiments, the mass ratio of the protective agent to the stabilizer is 0.15:(0.1-1).

[0026] In some embodiments, the mass ratio of the protective agent to the stabilizer is 0.2:(0.1-1).

[0027] Specifically, the mass ratio of the protective agent to the stabilizer can be 0.01:0.01, 0.01:0.05, 0.01:0.1, 0.01:0.5, 0.01:1, 0.01:1.5, 0.01:2, 0.01:2.5, 0.01:3, 0.02:0.01, 0.02:0.05, 0.02:0.1, 0. 02:0.5, 0.02:1, 0.02:1.5, 0.02:2, 0.02:2.5, 0.02:3, 0.05:0.1, 0.05:0.5, 0.05:1, 0.05:1.5, 0.05:2, 0.05:2.5, 0.05:3, 0.1:0.1, 0.1:0.5, 0.1:1, 0.1: 1.5, 0.1:2, 0.1:2.5, 0.1:3, 0.15:0.1, 0.15:0.5, 0.15:1, 0.15:1.5, 0.15:2, 0.15:2.5, 0.15:3, 0.2:0.1, 0.2:0.5, 0.2:1, 0.2:1.5, 0.2:2, 0.2:2.5, 0.2 :3, 0.25:0.1, 0.25:0.5, 0.25:1, 0.25:1.5, 0.25:2, 0.25:2.5, 0.25:3, 0.3:0.01, 0.3:0.05, 0.3:0.1, 0.3:0.5, 0.3:1, 0.3:1.5, 0.3:2, 0.3:2.5, 0.3:3, etc.

[0030] In some embodiments, the mass ratio of the protective agent to the protecting agent is (0.05-0.25): (0.1-2.5).

[0032] In some embodiments, the mass ratio of the protective agent to the protecting agent is 0.1:(0.1-2.5).

[0033] In some embodiments, the mass ratio of the protective agent to the protecting agent is 0.15:(0.1-2.5).

[0034] In some embodiments, the mass ratio of the protective agent to the protecting agent is 0.2:(0.1-2.5).

[0035] Specifically, the mass ratio of the protective agent to the protecting agent is 0.01:0.005, 0.01:0.01,

[0036] 0.01:0.015, 0.01:0.02, 0.01:0.05, 0.01:0.1, 0.01:0.5, 0.01:1, 0.01:1.5, 0.01:2, 0.01:2.5, 0.01:3, 0.01:3.5, 0.01:4, 0.01:4.5, 0.01:5, 0.02:0.005, 0.02:0.01, 0.02:0.015, 0.02:0.02, 0.02:0.05, 0.02:0.1, 0.02:0.5, 0.02:1, 0.02:1.5, 0.02:2, 0.02:2.5, 0.02 :3, 0.02:3.5, 0.02:4, 0.02:4.5, 0.02:5, 0.05:0.02, 0.05:0.05, 0.05:0.1, 0.05:0.5, 0.05:1, 0.05:1.5, 0.05:2, 0.05:2.5, 0.05:3, 0.05:3.5, 0.05:4, 0.05:4.5, 0.05:5, 0.1:0.02, 0.1:0.05, 0.1:0.1, 0.1:0.5, 0.1:1, 0.1:1.5, 0.1:2, 0.1:2.5, 0.1:3, 0.1:3.5, 0.1:4, 0 .1:4.5, 0.1:5, 0.15:0.02, 0.15:0.05, 0.15:0.1, 0.15:0.5, 0.15:1, 0.15:1.5, 0.15:2, 0.15:2.5, 0.15:3, 0.15:3.5, 0.15:4, 0.15:4.5, 0.15:5, 0.2:0.02, 0.2:0.05, 0.2:0.1, 0.2:0.5, 0.2:1, 0.2:1.5, 0.2:2, 0.2:2.5, 0.2:3, 0.2:3.5, 0.2:4, 0.2:4.5, 0.2:5, 0.25:0.0 2. 0.25:0.05, 0.25:0.1, 0.25:0.5, 0.25:1, 0.25:1.5, 0.25:2, 0.25:2.5, 0.25:3, 0.25:3.5, 0.25:4, 0.25:4.5, 0.25:5, 0.3:0.005, 0.3:0.01, 0.3:0.015, 0.3:0.02, 0.3:0.05, 0.3:0.1, 0.3:0.5, 0.3:1, 0.3:1.5, 0.3:2, 0.3:2.5, 0.3:3, 0.3:3.5, 0.3:4, 0.3:4.5, 0.3:5, etc.

[0044] In the present application, the protective agent is EDTA-2Na or EDTA-2K.

[0045] In the present application, the stabilizer is selected from one or more of inositol, erythritol, trehalose, xylitol, sorbitol, glucose, rhamnose, fructose, galactose, fucose, maltose, soluble proteoglycan, and ginseng polysaccharide.

[0046] In some embodiments, the stabilizer is inositol, erythritol, or trehalose.

[0047] In the present application, the protective agent is one or more of ergothioneine, acetylhydroxyproline, and raspberry glycosides, preferably acetylhydroxyproline.

[0048] In the present application, the phenolic hydroxy compound is a water-insoluble phenolic hydroxy compound.

[0049] The water-insoluble phenolic hydroxyl compound is phenethylresorcinol, 4-butylresorcinol, hexylresorcinol, resveratrol, pterostilbene and the like.

[0050] The composition for delaying the oxidation of a phenolic hydroxyl compound of the present application is used in delaying the oxidation of a phenolic hydroxyl compound.

[0051] The present application also provides a composition, including a phenolic hydroxyl compound and the aforementioned composition for delaying oxidation of the phenolic hydroxyl compound.

[0052] Furthermore, the phenolic hydroxy compound is dissolved in water to form a phenolic hydroxy compound system, and the mass ratio of the phenolic hydroxy compound system to the protective agent, stabilizer and protectant is 80: (0.01-0.3): (0.01-3): (0.005-5), and the preferred range is 80: (0.05-0.25): (0.1-1): (0.1-2.5).

[0053] The present application provides a composition, which consists of a phenolic hydroxyl compound system, a protective agent, a stabilizer, a protective agent and water, wherein the weight portion of the phenolic hydroxyl compound system is 80 parts, the weight portion of the protective agent is 0.01-0.3 parts, the weight portion of the stabilizer is 0.01-3 parts, the weight portion of the protective agent is 0.005-5 parts, and the balance is water.

[0054] In some embodiments, the mass ratio of the phenolic hydroxyl compound system to the protective agent is 80:(0.05-0.25).

[0055] In some embodiments, the mass ratio of the phenolic hydroxyl compound system to the protective agent is 80:(0.1-0.25).

[0056] Specifically, the mass ratio of the phenolic hydroxyl compound system to the protective agent can be 80:0.01, 80:0.02, 80:0.03, 80:0.04, 80:0.05, 80:0.06, 80:0.07, 80:0.08, 80:0.09, 80:0.1, 80:0.11, 80:0.12, 80:0.13, 80:0 0.14, 80:0.15, 80:0.16, 80:0.17, 80:0.18, 80:0.19, 80:0.2, 80:0.21, 80:0.22, 80:0.23, 80:0.24, 80:0.25, 80:0.26, 80:0.27, 80:0.28, 80:0.29, 80:0.3, etc.

[0057] In some embodiments, the mass ratio of the phenolic hydroxyl compound system to the stabilizer is 80:(0.1-3).

[0058] In some embodiments, the mass ratio of the phenolic hydroxyl compound system to the stabilizer is 80:(0.1-2).

[0059] In some embodiments, the mass ratio of the phenolic hydroxyl compound system to the stabilizer is 80:(0.1-1).

[0060] Specifically, the mass ratio of the phenolic hydroxyl compound system to the stabilizer can be 80:0.01, 80:0.02, 80:0.03, 80:0.04, 80:0.05, 80:0.06, 80:0.07, 80:0.08, 80:0.09, 80:0.1, 80:0.2, 80:0.3, 80:0.4, 80:0.5, 80:0.6, 80:0.7, 80:0.8, 80:0.9, 80:1, 80:1.1, 80:1.2, 80:1.3, 80:1.4, 80:1.5, 80:1.6, 80:1.7, 80:1.8,

[0061] 80:1.9, 80:2, 80:2.1, 80:2.2, 80:2.3, 80:2.4, 80:2.5, 80:2.6, 80:2.7, 80:2.8, 80:2.9, 80:3, etc.

[0062] In some embodiments, the mass ratio of the phenolic hydroxyl compound system to the protective agent is 80:(0.1-5).

[0063] In some embodiments, the mass ratio of the phenolic hydroxyl compound system to the protective agent is 80:(0.1-2.5).

[0064] Specifically, the mass ratio of the phenolic hydroxyl compound system to the protective agent is 80:0.005, 80:0.01, 80:0.02, 80:0.03, 80:0.04, 80:0.05, 80:0.06, 80:0.07, 80:0.08, 80:0.09, 80:0.1, 80:0.11, 80:0.12, 80:0.13, 80:0.14, 80:0.15, 80:0.16, 80:0.17 , 80:0.18, 80:0.19, 80:0.2, 80:0.21, 80:0.22, 80:0.23, 80:0.24, 80:0.25, 80:0.3, 80:0.4, 80:0.5, 80:0.6, 80:0.7, 80:0.8, 80:0.9, 80:1, 80:1.5, 80:2, 80:2.5, 80:3, 80:3.5, 80:4, 80:4.5, 80:5, etc.

[0065] In the present application, the phenolic hydroxy compound is a water-insoluble compound, and the phenolic hydroxy compound system also includes a solubilizing agent. The mass ratio of the phenolic hydroxy compound, the solubilizing agent and water is (0.001-1): (0.01-10): (0.01-18).

[0066] In some embodiments, the mass ratio of the phenolic hydroxyl compound to the solubilizing agent is (0.001-1): (0.01-10).

[0067] In some embodiments, the mass ratio of the phenolic hydroxyl compound to the solubilizing agent is 0.05:(0.01-10).

[0068] In some embodiments, the mass ratio of the phenolic hydroxyl compound to the solubilizing agent is 0.1:

[0069] (0.01-10).

[0070] In some embodiments, the mass ratio of the phenolic hydroxyl compound to the solubilizing agent is 0.5:

[0071] (0.01-10).

[0072] In some embodiments, the mass ratio of the phenolic hydroxyl compound to the solubilizing agent is 1:

[0073] (0.01-10).

[0074] Specifically, the mass ratio of the phenolic hydroxyl compound to the solubilizing agent can be 0.001:0.01, 0.001:0.05, 0.001:0.1, 0.001:0.2, 0.001:0.3, 0.001:0.4, 0.001:0.5, 0.001:0.6, 0.001:0.7, 0.001:0.8, 0.001:0.9, 0.001:1, 0.001:1.5, 0.001:2, 0.001:2.5, 0.001:3, 0.001:3.5, 0.001:4, 0.001:4.5, 0.001:5, 0.001:5. .001:5.5、0.001:6、0.001:7、0.001:8、0.001:9、0.001:10、0.05:0.01、0.05:0.05、0.05:0.1、0.05:0.2、0.05:0.3、0.05:0.4、0.05:0.5、0.05:0.6、0.05:0.7、0.05:0.8、0.05:0.9、0.05:1、0.05:1.5、0.05:2、0.05:2.5、0.05:3、0.05:3.5、0.05:4、0.05:4.5、0.0 5:5, 0.05:5.5, 0.05:6, 0.05:7, 0.05:8, 0.05:9, 0.05:10, 0.1:0.01, 0.1:0.1, 0.1:0.2, 0.1:0.3, 0.1:0.4, 0.1:0.5, 0.1:0.6, 0.1:0.7, 0.1:0.8, 0.1:0.9, 0.1:1, 0.1:2, 0.1:3, 0.1:4, 0.1:5, 0.1:6, 0.1:7, 0.1:8, 0.1:9, 0.1:10, 0.5:0.01, 0.5:0.1, 0.5:0.2, 0. : 5:0.3, 0.5:0.4, 0.5:0.5, 0.5:0.6, 0.5:0.7, 0.5:0.8, 0.5:0.9, 0.5:1, 0.5:2, 0.5:3, 0.5:4, 0.5:5, 0.5:6, 0.5:7, 0.5:8, 0.5:9, 0.5:10, 1:0.01, 1:0.1, 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.

[0083] In some embodiments, the mass ratio of the phenolic hydroxyl compound to water is (0.001-1):

[0084] (0.01-18).

[0085] In some embodiments, the mass ratio of the phenolic hydroxyl compound to water is 0.001:(0.01-18).

[0086] In some embodiments, the mass ratio of the phenolic hydroxyl compound to water is 0.05:(0.01-18).

[0087] In some embodiments, the mass ratio of the phenolic hydroxyl compound to water is 1:(0.01-18).Specifically, the mass ratio of the phenolic hydroxyl compound to water can be 0.001:0.01, 0.001:0.05, 0.001:0.1, 0.001:0.2, 0.001:0.3, 0.001:0.4, 0.001:0.5, 0.001:0.6, 0.001:0.7, 0.001:0.8, 0.001:0.9, 0.001:1, 0.001:1.5, 0.001:2, 0.001:2.5, 0.001:3, 0.001:3.5, 0.001:4, 0.001:4.5, 0.001:5, 0.001:5.5, 0.001:6, 0.001:7, 0.001:8 :8, 0.001:9, 0.001:10, 0.001:13, 0.001:15, 0.001:18, 0.05:0.01, 0.05:0.05, 0.05:0.1, 0.05:0.2, 0.05:0.3, 0.05:0.4, 0.05:0.5, 0.05:0.6, 0.05:0.7, 0.05:0.8, 0.05:0.9, 0.05:1, 0.05:1.5, 0.05:2, 0.05:2.5, 0.05:3, 0.05:3.5, 0.05:4, 0.05:4.5, 0.05:5, 0.05:5.5, 0.05:6, 0.05:7, 0. 0.5:8、0.05:9、0.05:10、0.05:13、0.05:15、0.05:18、0.1:0.01、0.1:0.1、0.1:0.2、0.1:0.3、0.1:0.4、0.1:0.5、0.1:0.6、0.1:0.7、0.1:0.8、0.1:0.9、0.1:1、0.1:2、0.1:3、0.1:4、0.1:5、0.1:6、0.1:7、0.1:8、0.1:9、0.1:10、0.1:13、0.1:15、0.1:18、0.5:0.01、0.5:0.1、0.5:0.2、0.5:0.3、0.5: : 0.4, 0.5:0.5, 0.5:0.6, 0.5:0.7, 0.5:0.8, 0.5:0.9, 0.5:1, 0.5:2, 0.5:3, 0.5:4, 0.5:5, 0.5:6, 0.5:7, 0.5:8, 0.5:9, 0.5:10, 0.5:13, 0.5:15, 0.5:18, 1:0.01, 1:0.1, 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:13, 1:15, 1:18, etc.

[0099] Furthermore, the solubilizing agent is selected from one or more of betaine, dipropylene glycol, dimethyl isosorbide, trimethylpentanediol / adipic acid / glycerol cross-linked polymer or PEG / PPG-17 / 6 copolymer.

[0100] In some embodiments, the solubilizing agent is a combination of betaine and dipropylene glycol, and the mass ratio of betaine to dipropylene glycol is (0.5-10):1, for example, it can be 0.5:1, 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, 5.5:1, 6:1, 6.5:1, 7:1, 7.5:1, 8:1, 8.5:1, 9:1, 9.5:1, 10:1, etc.

[0101] The present application also provides a composition for delaying the oxidation of a phenolic hydroxyl compound or use of the composition in cosmetics.

[0102] Example

[0103] The experimental methods used in the following examples are all conventional methods unless otherwise specified.

[0104] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0105] Example 1

[0106] The composition in this embodiment is composed of a phenolic hydroxyl compound system, a protective agent, a stabilizer, a protective agent and water, and is obtained by mixing 80 g of a phenolic hydroxyl compound system (0.5 g of phenethyl resorcinol, 39.8 g of dipropylene glycol, 19.9 g of betaine, and 19.8 g of water), 0.1 g of a protective agent, 0.5 g of a stabilizer, 0.02 g of a protective agent and water (water is the balance). The various parameters of the composition are shown in Tables 1 and 2.

[0107] The test conditions and methods in Table 2 are as follows: the composition samples in the embodiments and comparative examples are placed in an electric constant temperature incubator (product model: XY-DRL-350), the temperature is set to 50°C, the temperature fluctuation is ±1°C, the samples are taken out at the specified time, placed at 25°C, and the color changes are observed by visual inspection.

[0108] The difference between Example 2 to Example 9 and Example 1 is that the content of the protective agent, protectant or stabilizer is different. The various parameters of the composition are shown in Table 1 and Table 2.

[0109] The difference between Example 10 and Example 7 is that the types of phenolic hydroxyl compounds are different, and other parameters are the same. The parameters of the composition are shown in Table 1 and Table 2.

[0110] The difference between Example 11 to Example 13 and Example 4 is that the types of phenolic hydroxyl compounds are different, and other parameters are the same. The parameters of the composition are shown in Table 1 and Table 2.

[0111] The difference between Example 14 and Example 7 is that the type of protective agent is different, and the other parameters are the same. The parameters of the composition are shown in Table 1 and Table 2.

[0112] The difference between Example 15 and Example 7 is that the types of protective agents are different, and other parameters are the same. The parameters of the composition are shown in Table 1 and Table 2.

[0113] The difference between Example 16 and Example 17 and Example 7 is that the types of stabilizers are different, and other parameters are the same. The parameters of the composition are shown in Table 1 and Table 2.

[0114] The difference between Example 18 and Example 7 is that the type of phenolic hydroxyl compound is different, and the other parameters are the same. The parameters of the composition are shown in Table 1 and Table 2.

[0115] The difference between Comparative Examples 1 to Comparative Examples 10 and Example 1 is that the content of the protective agent, stabilizer or protecting agent is different, and other parameters are the same. The various parameters of the composition are shown in Table 1 and Table 2.

[0116] The difference between Comparative Example 11 and Example 7 is that the type of protective agent is different, and the other parameters are the same. The parameters of the composition are shown in Table 1 and Table 2.

[0117] The difference between Comparative Examples 12 and 13 and Example 7 is that the types of stabilizers are different, and other parameters are the same. The parameters of the composition are shown in Tables 1 and 2.

[0118] The difference between Comparative Example 14 and Example 7 is that the type of protective agent is different, and the other parameters are the same. The parameters of the composition are shown in Table 1 and Table 2.

[0119] The difference between Comparative Example 15 and Example 7 is that there is no protective agent, stabilizer and protectant. Other parameters are the same, and the parameters of the composition are shown in Table 1 and Table 2.

[0120] Comparative Examples 16 to 19 are different from Comparative Example 15 in that the types of phenolic hydroxyl compounds are different. Other parameters are the same, and the parameters of the composition are shown in Table 1 and Table 2.

[0121] Table 1 shows the parameters of each embodiment and comparative example.

[0122]

[0123]

[0124] Table 2 shows the performance of each embodiment and comparative example.

[0125]

[0126]

[0127] Note: 0 means no color change, △ means partial precipitation and incomplete dissolution, color change degree rating: Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅴ, Ⅵ, Ⅶ, Ⅷ, Ⅰ means the lightest color change, which is slightly yellow or slightly brown, Ⅷ means the darkest color change, which is dark yellow or brown.

[0128] Summary: The color of the compositions in Example 7, Example 12, Comparative Examples 15-18 after being placed for 50 days is as follows: Figure 1 Combining Table 1 and Table 2, it can be seen that the composition for delaying the oxidation of phenolic hydroxyl compounds of the present application can greatly improve the thermal stability of phenolic hydroxyl compounds and delay the color change reaction.

[0129] Although the embodiments of the present application are described above, the present application is not limited to the above specific embodiments and application fields, and the above specific embodiments are merely illustrative and instructive, rather than restrictive. A person of ordinary skill in the art can make many forms under the guidance of this specification and without departing from the scope of protection of the claims of the present application, all of which belong to the protection of the present application.

Claims

1. A composition for delaying the oxidation of a phenolic hydroxyl compound, wherein: It comprises a protective agent, a stabilizer and a protecting agent, wherein the mass ratio of the protective agent, the stabilizer and the protecting agent is (0.01-0.3): (0.01-3): (0.005-5).

2. The composition according to claim 1, wherein The protective agent is EDTA-2Na or EDTA-2K.

3. The composition according to claim 1, wherein The stabilizer is selected from one or more of inositol, erythritol, trehalose, xylitol, sorbitol, glucose, rhamnose, fructose, galactose, fucose, maltose, soluble proteoglycan, and ginseng polysaccharide.

4. The composition according to claim 1, wherein The protective agent is one or more than two of ergothioneine, acetylhydroxyproline and raspberry glycoside.

5. The composition according to claim 1, wherein The phenolic hydroxy compound is selected from one or more of phenethyl resorcinol, 4-butyl resorcinol, hexyl resorcinol, n-octyl resorcinol, 4-pentyl resorcinol, 4-propyl resorcinol, 2-n-propyl resorcinol, 2-methyl resorcinol, 4-benzyl-1,3-benzene, 5-undecyl resorcinol, 4-methyl resorcinol, isopropyl catechol, 4-butyl catechol, 3-butyl catechol, 3-methyl catechol, 3-ethoxy catechol, resveratrol, pterostilbene, 3'-hydroxypterostilbene, resveratrol-4'-methyl ether, and dihydro-resveratrol.

6. Use of the composition for delaying the oxidation of phenolic hydroxyl compounds according to any one of claims 1 to 5 in delaying the oxidation of phenolic hydroxyl compounds.

7. A composition, wherein The invention comprises a phenolic hydroxyl compound and the composition for delaying the oxidation of the phenolic hydroxyl compound as claimed in any one of claims 1 to 5.

8. The composition according to claim 7, wherein The phenolic hydroxy compound is dissolved in water to form a phenolic hydroxy compound system, and the mass ratio of the phenolic hydroxy compound system to the protective agent, the stabilizer and the protecting agent is 80: (0.01-0.3): (0.01-3): (0.005-5).

9. The composition according to claim 7, wherein The phenolic hydroxy compound is a water-insoluble compound. The phenolic hydroxy compound system also includes a solubilizing agent. The mass ratio of the phenolic hydroxy compound, the solubilizing agent and water is (0.001-1): (0.01-10): (0.01-18).

10. The composition according to claim 9, wherein The solubilizing agent is selected from one or more of betaine, dipropylene glycol, dimethyl isosorbide, trimethylpentanediol / adipic acid / glycerol cross-linked polymer or PEG / PPG-17 / 6 copolymer.

11. The composition according to claim 10, wherein The solubilizing agent is a combination of betaine and dipropylene glycol, and the mass ratio of the betaine to dipropylene glycol is (0.5-10):

1.

12. Use of the composition for delaying oxidation of phenolic hydroxyl compounds according to any one of claims 1 to 5 or the composition according to any one of claims 7 to 11 in cosmetics.

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