Tumor drug resistance detection device based on artificial intelligence

Abstract

The invention relates to the technical field of tumor detection, in particular to a tumor drug resistance detection device based on artificial intelligence. Comprising a bottom frame, the bottom frame is fixedly connected with a shell, the shell is provided with a hydraulic push rod, the telescopic end of the hydraulic push rod is fixedly connected with a transverse rod, the transverse rod is fixedly connected with a first moving rod, the first moving rod is fixedly connected with a first piston plate, the bottom frame is provided with a first motor, and an output shaft of the first motor is fixedly connected with a rotating plate. The rotating plate is provided with a middle plate, the middle plate is in sliding connection with a first sliding column, and the first sliding column is provided with a cooling plate. The first piston plate is used for compressing air in the shell, and the cooling plate is used for cooling the nearby area, so that tumor cells are in a high-pressure and low-temperature environment similar to deep sea in the drug resistance detection process, and the normal living environment of the tumor cells in the drug resistance detection process is improved; and inaccurate detection caused by the change of the living environment is avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of tumor detection, and in particular to a tumor drug resistance detection device based on artificial intelligence. Background Art

[0002] Tumor cells, as mutated cells, can bring a fatal burden to the body. If tumor cells are found in the body, they are generally treated by a combination of drugs and surgery. As the medication time increases, tumor cells will develop drug resistance. In order to better formulate a treatment plan, it is usually necessary to test the drug resistance of tumor cells. Since the high-intelligence system (i.e., artificial intelligence) has functions such as self-processing, it can greatly reduce the workload of staff. Most of the existing detection technologies perform drug resistance detection on tumor cells in a standard atmospheric environment by combining a high-intelligence system with the detection device itself. The drug resistance detection device has a variety of application objects. When performing drug resistance detection on tumor cells in deep-sea fish, since the existing detection device is only performed in a standard atmospheric environment, it is impossible to make corresponding changes according to the living environment of the tumor cells in the deep-sea fish. As a result, the results of the drug resistance detection of tumor cells are inaccurate. Therefore, the present application proposes an artificial intelligence-based tumor resistance detection device to solve the above problem. Summary of the invention

[0003] In order to overcome the shortcomings mentioned in the above technical background, the present invention provides a tumor resistance detection device based on artificial intelligence.

[0004] The technical solution is: a tumor drug resistance detection device based on artificial intelligence, comprising a base frame, the base frame is fixedly connected to a shell, the base frame is installed with an intelligent monitoring center, the shell is hinged with a flip cover, the shell and the flip cover are both provided with observation windows, a recording lens electrically connected to the intelligent monitoring center is installed at the observation window of the flip cover, a hydraulic push rod is installed on the side of the shell away from the base frame, the telescopic end of the hydraulic push rod is fixedly connected to a cross bar, the end of the cross bar away from the hydraulic push rod is fixedly connected to a first moving rod, and the end of the first moving rod close to the base frame is fixedly connected to a first movable rod. The plug plate, the first piston plate is sealingly and slidingly connected to the shell, the base frame is equipped with a first motor, the output shaft of the first motor is sealingly and rotatably connected to the shell, the output shaft of the first motor is fixedly connected to a rotating plate, an intermediate plate is provided on the side of the rotating plate away from the first motor, the intermediate plate is slidingly connected to the first sliding column of the annular array, the first sliding columns of the annular array are jointly equipped with a cooling plate electrically connected to the intelligent monitoring center, an adding mechanism for adding materials is provided in the shell, and a clamping mechanism for clamping the detection dish is provided in the middle of the intermediate plate.

[0005] Further description, the adding mechanism includes a connecting frame, the connecting frame is arranged in the shell, the connecting frame is provided with an intermediate piece, the first channel and the second channel are provided in the intermediate piece, the first channel and the second channel are both installed with a one-way valve, the outside of the intermediate piece is provided with a first ring and a second ring, the base frame is fixedly connected with symmetrically arranged storage shells, the symmetrically arranged storage shells are respectively filled with nutrient medium and oxidizing medium, the symmetrically arranged storage shells are respectively connected to external medium filling devices, intermediate pipes are connected between the first channel and the storage shell filled with the nutrient medium and between the second channel and the storage shell filled with the oxidizing medium, the first ring and the second ring are respectively fixedly connected to adjacent intermediate pipes, and a power component for discharging the medium of the symmetrically arranged storage shells is provided on the side of the shell away from the base frame.

[0006] Further description, the power assembly includes a second motor, the second motor is installed on the side of the shell away from the base frame, the output shaft of the second motor is fixedly connected to the first gear, the storage shells are symmetrically fixedly connected to the mounting frame, the mounting frame is rotatably connected to the second gear, the side of the shell close to the first gear is rotatably connected to the first ring gear, the first gear and the symmetrically arranged second gear are both meshed with the first ring gear, the storage shell is slidably connected to the second moving rod, the second moving rod is provided with a first limiting groove, the second gear is fixedly connected to the inside of the protrusion which is limited by the adjacent first limiting groove, the storage shell is sealingly and slidably connected to the second piston plate, the second piston plate is fixedly connected to the adjacent second moving rod.

[0007] It is further explained that the first limiting groove is a spiral groove, and the pitch of the first limiting groove changes gradually, so as to enable the adjacent second piston plate to move at a variable speed.

[0008] It is further explained that an air outlet pipe is fixedly connected to one side of the middle piece close to the base frame, and the air outlet pipe is connected to the second channel.

[0009] Further description, the clamping mechanism includes a second sliding column, the second sliding column is slidably connected to the middle plate, a first elastic element is fixedly connected between the second sliding column and the middle plate, the middle plate is slidably connected to a clamping rod in an annular array, a second elastic element is fixedly connected between the clamping rod and the middle plate, opposite ends of the clamping rods in the annular array are slidably connected to symmetrically arranged limiting columns, a third elastic element is fixedly connected between the first sliding column and the middle plate, the second sliding column is provided with a second limiting groove arranged in an annular array and symmetrically, the second limiting groove is limitedly cooperated with adjacent limiting columns, a fourth elastic element is fixedly connected between adjacent and symmetrically arranged limiting columns, and a one-way plate is fixedly connected in the second limiting groove.

[0010] It is further explained that the second limiting groove is composed of an oblique groove, a long vertical groove, a transverse groove and a short vertical groove connected end to end, and the distance between the adjacent and symmetrically arranged short vertical grooves gradually increases from one side close to the cooling plate to the other side, and the groove depth of the transverse groove is smaller than the groove depth of the adjacent long vertical groove.

[0011] Further description, it also includes an extrusion mechanism for moving the connecting frame, the extrusion mechanism is arranged in the shell, the extrusion mechanism includes an elastic telescopic rod, the elastic telescopic rod is fixed to the side of the first piston plate away from the first moving rod, the rotating plate is rotatably connected to the middle plate, the connecting frame is slidably connected to the shell, the connecting frame is rotatably connected to the middle piece, the first ring and the second ring are both rotatably connected to the middle piece, the telescopic end of the elastic telescopic rod is fixed to the connecting frame, and a symmetrically arranged fifth elastic element is fixed between the connecting frame and the shell.

[0012] It is further explained that the output shaft of the first motor is located at an eccentric position of the rotating plate, a second gear ring is fixedly connected to one side of the housing close to the base frame, a third gear ring is fixedly connected to the outer side of the middle plate, and the third gear ring is meshed with the second gear ring.

[0013] It is further explained that a fixing rod is fixedly connected to the output shaft of the first motor, the fixing rod is slidably matched with the intermediate component, and an absorbing component is installed on a side of the fixing rod away from the first motor.

[0014] Compared with the prior art, the present invention has at least the following beneficial effects: 1. The present invention utilizes the first piston plate to compress the air in the housing and the cooling plate to cool the nearby area, so that the tumor cells are in a high pressure and low temperature environment similar to that in the deep sea during the drug resistance detection process, thereby improving the normal living environment of the tumor cells during the drug resistance detection process and avoiding inaccurate detection due to changes in the living environment; 2. The second piston plates are symmetrically arranged to slide in adjacent storage shells, and glucose solution and oxygen are added to the detection environment of tumor cells, so as to ensure that the death of tumor cells during drug resistance detection is only affected by drug factors, thereby improving the representativeness of the detection results; 3. Use the oxidizing medium from the gas outlet to drive the flow of gas above the culture dish, thereby accelerating the evaporation of water in the culture dish, preventing the additional water produced by tumor cell metabolism from affecting the concentration of various components in the culture dish, thereby affecting the results of tumor cell resistance detection; 4. The culture dish is rotated during the detection process so that the nutrient medium can enter the culture dish evenly, avoiding the nutrient medium from gathering in the culture dish, resulting in excessive concentration of the nutrient medium locally in the culture dish, thereby causing an osmotic pressure effect, causing unexpected death of tumor cells, and affecting the normal detection process. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the overall three-dimensional structure of the present invention; Figure 2 It is a three-dimensional structural cross-sectional view of the base frame and its upper parts of the present invention; Figure 3 It is a three-dimensional structural schematic diagram of the housing and its internal parts of the present invention; Figure 4 For the present invention Figure 3 A magnified view of the three-dimensional structure at center A; Figure 5 It is a three-dimensional structural schematic diagram of the rotating plate and the middle piece and the parts thereon of the rotating plate and the middle piece of the present invention; Figure 6 It is a three-dimensional structural schematic diagram of the rotating plate and parts thereon of the present invention; Figure 7 It is a three-dimensional structural exploded view of the second sliding column and its upper parts of the present invention; Figure 8 It is a three-dimensional structural schematic diagram of the housing and its internal parts of the present invention; Fig. 9 It is a three-dimensional structural exploded diagram of the middle plate and the parts thereon of the present invention; Fig.10 It is a three-dimensional structural schematic diagram of the fixing rod and the parts thereon of the present invention.

[0016] Markings in the accompanying drawings: 101: culture dish, 1: base frame, 2: shell, 3: intelligent monitoring center, 4: flip cover, 5: recording lens, 6: hydraulic push rod, 7: cross bar, 8: first moving rod, 9: first piston plate, 10: first motor, 11: rotating plate, 1201: middle plate, 1202: first sliding column, 13: cooling plate, 1401: connecting frame, 1402: middle piece, 1403: first channel, 1404: second channel, 1405: first ring, 1406: second ring, 1407: storage shell, 1408: middle tube, 1501: second motor, 1502: first gear, 1503: mounting frame, 1504: second gear, 1505: first gear ring , 1506: second moving rod, 1507: first limiting groove, 1508: second piston plate, 16: exhaust pipe, 1701: second sliding column, 1702: first elastic element, 1703: clamping rod, 1704: second elastic element, 1705: limiting column, 1706: third elastic element, 1707: second limiting groove, 17071: oblique groove, 17072: long vertical groove, 17073: short vertical groove, 17074: horizontal groove, 1708: fourth elastic element, 1709: one-way plate, 1801: elastic telescopic rod, 1802: fifth elastic element, 1901: second gear ring, 1902: third gear ring, 2001: fixing rod, 2002: absorption member. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] When existing detection devices are used to detect drug resistance in tumor cells whose living environment is the deep sea, they are unable to simulate the normal growth environment of tumor cells, resulting in inaccurate detection results of tumor cell resistance.

[0019] Embodiment 1: A tumor drug resistance detection device based on artificial intelligence, such as Figure 1-Figure 3As shown, it includes a base frame 1, a shell 2 is fixedly connected to the upper side of the base frame 1, and an intelligent monitoring center 3 is installed on the left part of the base frame 1. The intelligent monitoring center 3 involves the field of artificial intelligence, which is a prior art and will not be described in detail here. A flip cover 4 is hinged on the lower part of the front side of the shell 2, and a transparent observation window is provided on the upper part of the front side of the shell 2 and the middle part of the flip cover 4, so that the staff can observe the situation inside the shell 2 in real time. A recording lens 5 electrically connected to the intelligent monitoring center 3 is installed in the middle and upper part of the observation window on the flip cover 4. The recording lens 5 uses live cell imaging technology (prior art, used to record the real-time growth status of tumor cells), and its working principle is not described in detail here. Two hydraulic push rods 6 arranged symmetrically on the left and right are installed on the upper part of the outer side of the shell 2, and the telescopic ends of the hydraulic push rods 6 are fixedly connected to cross bars 7, and the opposite ends of the two cross bars 7 are commonly fixedly connected to a first moving rod 8, and the lower end of the first moving rod 8 is fixedly connected to a first moving rod 8 which is sealingly and slidably connected to the shell 2. A piston plate 9, a first motor 10 is installed on the base frame 1, the output shaft of the first motor 10 is sealed and rotatably connected to the shell 2, the output shaft of the first motor 10 is fixedly connected to the rotating plate 11, and an intermediate plate 1201 is arranged on the upper side of the rotating plate 11, the intermediate plate 1201 is slidably connected with three first sliding columns 1202 in a ring array, and the three first sliding columns 1202 are jointly installed with a cooling plate 13 electrically connected to the intelligent monitoring center 3, the cooling plate 13 is used to change the temperature in the detection environment, and the air in the shell 2 is compressed by the first piston plate 9, so that the detection environment in the shell 2 is in a high-pressure environment similar to the deep sea, and the cooling plate 13 is used to cool the surrounding space, simulating the low-temperature environment of the deep sea position, so that the detection environment is the same as the growth environment of tumor cells, thereby improving the detection effect, an adding mechanism for adding materials is arranged in the shell 2, and a clamping mechanism for clamping the detection dish is arranged in the middle of the intermediate plate 1201.

[0020] like Figure 2 , Figure 3 and Figure 5As shown, the adding mechanism includes a connecting frame 1401, the connecting frame 1401 is arranged in the middle of the shell 2, and a middle piece 1402 is arranged in the middle of the connecting frame 1401. A first channel 1403 and a second channel 1404 are arranged in the middle piece 1402. Check valves are installed in the first channel 1403 and the second channel 1404. The flow direction of the check valve is from top to bottom. A first ring 1405 and a second ring 1406 are arranged on the outside of the middle piece 1402. Two storage shells 1407 arranged symmetrically on the left and right are fixedly connected to the upper side of the bottom frame 1. The storage shell 1407 on the left is filled with an oxidizing medium, which is oxygen, and the storage shell 1407 on the right is filled with a nutrient medium, which is a glucose solution. Liquid, the two storage shells 1407 are respectively connected to the external medium filling device, and oxygen and glucose are added during the detection process to supplement the consumption in the culture dish 101 due to tumor cell proliferation, ensuring that the death of tumor cells is only affected by drugs, thereby improving the effect of tumor cell resistance detection. The first channel 1403 and the storage shell 1407 on the right and the second channel 1404 and the storage shell 1407 on the left are connected by an intermediate tube 1408, the intermediate tube 1408 is made of elastic deformable material, the first ring 1405 and the second ring 1406 are respectively fixed to the adjacent intermediate tube 1408, and the upper side of the shell 2 is provided with a power component for discharging the medium in the two storage shells 1407.

[0021] like Figure 1-Figure 4 As shown, the power assembly includes a second motor 1501, which is installed on the upper right part of the outer side of the shell 2, and the output shaft of the second motor 1501 is fixedly connected to the first gear 1502. The back sides of the two storage shells 1407 are fixedly connected to the mounting frame 1503, and the mounting frame 1503 is rotatably connected to the second gear 1504. The upper part of the outer side of the shell 2 is rotatably connected to the first ring gear 1505, and the first gear 1502 and the two second gears 1504 are all meshed with the first ring gear 1505. The storage shell 1407 is slidably connected to the second moving rod 1506, and the second moving rod 1506 is provided with a first limiting groove 1507, and the first limiting groove 1507 is a spiral groove, and the first limiting groove 1507 is a spiral groove. The pitch of a limiting groove 1507 gradually decreases from top to bottom to adapt to the amount of oxygen and glucose required for tumor cell proliferation (the pitch change of the first limiting groove 1507 can be changed accordingly according to different situations). A protrusion is fixedly connected to the second gear 1504. The second gear 1504 drives the adjacent protrusions to rotate together during the rotation process, and squeezes the adjacent first limiting groove 1507 to move the second moving rod 1506. A second piston plate 1508 fixedly connected to the adjacent second moving rod 1506 is sealed and slidably connected in the storage shell 1407. The lower side of the middle piece 1402 is fixedly connected to the air outlet pipe 16, and the air outlet pipe 16 is connected to the second channel 1404.

[0022] like Figure 3, Figure 5-Figure 7 and Fig. 9 As shown, the clamping mechanism includes a second sliding column 1701, the second sliding column 1701 is slidably connected to the middle part of the middle plate 1201, a first elastic element 1702 is fixedly connected between the second sliding column 1701 and the middle plate 1201, the first elastic element 1702 is a spring, and is used to reset the second sliding column 1701, the middle plate 1201 is slidably connected to three clamping rods 1703 in an annular array, a rubber pad is provided on the upper side of the clamping rod 1703, the clamping rod 1703 is used to clamp and fix the culture dish 101, and the clamping rod 1703 is fixedly connected to the middle plate 1201. There is a second elastic element 1704, which is a spring and is used to reset the adjacent clamping rods 1703. The opposite ends of the three clamping rods 1703 are slidably connected with two symmetrically arranged limiting columns 1705, and the two adjacent and symmetrically arranged limiting columns 1705 form a group. A third elastic element 1706 is fixedly connected between the first sliding column 1202 and the middle plate 1201. The third elastic element 1706 is a spring and is used to reset the adjacent first sliding column 1202. The second sliding column 1701 is provided with three groups of second limiting grooves 1707 in an annular array, each The group contains two symmetrically arranged second limiting grooves 1707, the shape of the second limiting grooves 1707 is a right-angled trapezoid, the second limiting grooves 1707 are composed of an oblique groove 17071, a long vertical groove 17072, a transverse groove 17074 and a short vertical groove 17073 connected end to end, and the distance between the two adjacent and symmetrically arranged short vertical grooves 17073 gradually increases from top to bottom, the groove depth of the transverse groove 17074 is less than the groove depth of the adjacent long vertical groove 17072, and a groove is provided in the short vertical groove 17073 to cooperate with the adjacent limiting column 1705. The adjacent limiting columns 1705 are limited so that the two adjacent and symmetrically arranged limiting columns 1705 move relative to each other during the sliding process. A fourth elastic element 1708 is fixedly connected between the two adjacent and symmetrically arranged limiting columns 1705. The fourth elastic element 1708 is a spring and is used to reset the two adjacent limiting columns 1705. A one-way plate 1709 is fixedly connected to the second limiting groove 1707 and cooperates with the adjacent limiting columns 1705 to limit the position. The one-way plate 1709 is a spring plate and can initially only swing downward, so as to allow the adjacent limiting columns 1705 to pass downward in one direction.

[0023] When the device is needed to detect drug resistance of tumor cells in deep-sea fish, the staff first opens the flap 4, and then places the culture dish 101 containing tumor cells, drugs and nutrient medium on the second sliding column 1701. Then the staff presses the culture dish 101 downward, and the culture dish 101 drives the second sliding column 1701 to start moving downward. The second sliding column 1701 compresses the first elastic element 1702, and at the same time, the limiting column 1705 starts to slide in the adjacent inclined groove 17071. Next, the three groups of limiting columns 1705 begin to move toward each other, and the two limiting columns 1705 in the same group jointly drive the adjacent clamping rods 1703 to move together. The clamping rods 1703 compress the adjacent second elastic elements 1704, and then the three clamping rods 1703 flexibly clamp the culture dish 101 through the rubber pads thereon. When the culture dish 101 moves downward until it contacts the cooling plate 13 and stops moving, the limiting columns 1705 move into the adjacent short vertical grooves 17073 and are limited by the adjacent grooves, thereby completing the clamping of the culture dish 101.

[0024] After completing the clamping of the culture dish 101, the staff closes the flap 4 and starts the two hydraulic push rods 6 and the cooling plate 13 through the intelligent monitoring center 3. The telescopic ends of the two hydraulic push rods 6 begin to move downward, and the cooling plate 13 begins to cool the surrounding space. The telescopic ends of the two hydraulic push rods 6 respectively drive the adjacent cross bars 7 to move downward together, and the two cross bars 7 jointly drive the first moving rod 8 to move downward together, and the first moving rod 8 drives the first piston plate 9 to move downward together. The first piston plate 9 slides relative to the shell 2, and the air pressure in the shell 2 begins to increase. When the pressure in the shell 2 and the temperature of the surrounding environment change to a level equivalent to the living environment of deep-sea fish, the staff closes the two hydraulic push rods 6 and the cooling plate 13 through the intelligent monitoring center 3, and uses the first piston plate 9 to compress the air in the shell 2 and the cooling plate 13 to cool the surrounding space, so that the tumor cells are in a high-pressure and low-temperature environment similar to the deep sea during the drug resistance detection process, so that the tumor cells are in a normal living environment during the drug resistance detection process, avoiding inaccurate detection due to changes in the living environment.

[0025] In order to improve the accuracy of the detection results, the second piston plate 1508 slides in the adjacent storage shell 1407 and replenishes glucose solution and oxygen into the detection environment of the tumor cells, thereby ensuring that the death of the tumor cells is only affected by drug factors. The specific steps are as follows: when the environment in the shell 2 changes to the same as the deep-sea environment, the staff starts the second motor 1501, and the output shaft of the second motor 1501 begins to rotate counterclockwise (looking down), and the output shaft of the second motor 1501 drives the first gear 1502 to rotate counterclockwise together. The first gear 1502 drives the two second gears 1504 to rotate counterclockwise through the first gear ring 1505, and then the protrusion on the second gear 1504 begins to slide in the adjacent first limiting groove 1507. Under the squeezing action of the protrusion on the adjacent second gear 1504, the adjacent second moving rod 1506 begins to move downward, and the second moving rod 1506 drives the adjacent second piston plate 1508 to move downward together, and the second piston plate 1508 on the left side begins to squeeze the oxygen in the left storage shell 1407, and the second piston plate 1508 on the right side begins to squeeze the left The glucose solution in the storage shell 1407 and the oxygen in the left storage shell 1407 enter the second channel 1404 through the left middle tube 1408, and the glucose solution in the right storage shell 1407 enters the first channel 1403 through the right middle tube 1408, and then the glucose solution and oxygen are discharged from the middle piece 1402 after passing through the adjacent one-way valves, and the glucose solution directly falls downward into the culture dish 101, so as to supplement the nutrients consumed by the tumor cells in the culture dish 101, prevent the situation that the tumor cells in the culture dish 101 are not sufficient and cause the accidental death of the tumor cells, and finally reduce the representativeness of the detection result. During the process, the oxygen is blown to the culture dish 101 through the air outlet pipe 16, so that the flow of oxygen makes the gas above the culture dish 101 flow, so as to supplement the living environment of the tumor cells with oxygen while accelerating the evaporation of the extra water generated by the metabolism of the tumor cells in the culture dish 101, that is, to ensure the stability of the tumor cell detection environment, and prevent the extra water from affecting the concentration of the culture fluid of the tumor cells in the culture dish 101, thereby affecting the normal detection.

[0026] During the process of drug resistance detection of tumor cells, the recording lens 5 always observes and records the number and morphology of tumor cells in the culture dish 101, and transmits the data to the intelligent monitoring center 3 in real time. The intelligent monitoring center 3 then analyzes the obtained data and presents it to the staff in a digital display form, so that the staff can intuitively observe the drug resistance detection process of tumor cells in real time.

[0027] In order to improve the accuracy of the tumor cell drug resistance test results, the rotating plate 11 drives the middle plate 1201 to rotate, so that the culture dish 101 rotates around the axis of the output shaft of the first motor 10 during the test process, so that the culture dish 101 shakes during the test process, so as to disperse the glucose entering the culture dish 101 and disperse the aggregated tumor cells, so that they are fully in contact with the drug and the nutrient medium. The specific steps are as follows: during the counterclockwise rotation of the first gear 1502, the staff starts the first motor 10 through the intelligent monitoring center 3, and the output shaft of the first motor 10 starts to rotate clockwise (in the top view direction). ), the output shaft of the first motor 10 drives the rotating plate 11 to rotate clockwise, and the rotating plate 11 drives the middle plate 1201 and the parts thereon to rotate clockwise, and then the culture dish 101 starts to rotate clockwise around the axis of the output shaft of the first motor 10, so as to shake the components in the culture dish 101, so that the components in the culture dish 101 are evenly distributed, and at the same time, the position of the glucose solution when it is dripped into the culture dish 101 is changed, so as to further improve the uniform state of glucose in the culture dish 101, so that the tumor cells are evenly contacted with the various components in the culture dish 101, thereby improving the accuracy of the tumor cell resistance detection results.

[0028] After completing the drug resistance test of tumor cells, the staff starts the two hydraulic push rods 6 through the intelligent monitoring center 3. The telescopic ends of the two hydraulic push rods 6 start to move upward, and the telescopic ends of the hydraulic push rods 6 drive the adjacent cross bars 7 to move upward together. The two cross bars 7 jointly drive the first moving rod 8 to move upward together, and the first moving rod 8 drives the first piston plate 9 to move upward together. The air pressure in the housing 2 gradually decreases until the first moving rod 8 is completely reset. The staff closes the two hydraulic push rods 6, and then opens the flip cover 4. Then the staff further The culture dish 101 is pressed downward, the culture dish 101 drives the cooling plate 13 and the second sliding column 1701 to move downward together, the cooling plate 13 drives the three first sliding columns 1202 to move downward together, the first sliding column 1202 squeezes the adjacent third elastic element 1706, the second sliding column 1701 further compresses the first elastic element 1702, during which the limiting column 1705 moves toward the middle again under the action of the adjacent groove, the limiting column 1705 drives the adjacent clamping rod 1703 to move together, and the rubber pad on the clamping rod 1703 is further deformed. At the same time, the two limiting columns 1705 in the same group begin to move toward each other under the squeezing action of the adjacent short vertical grooves 17073, and the two limiting columns 1705 in the same group jointly squeeze an adjacent fourth elastic element 1708. When the limiting column 1705 enters the adjacent transverse groove 17074, the three clamping rods 1703 begin to move backwards under the action of the elastic force of the adjacent second elastic element 1704, that is, the clamping of the culture dish 101 is lost. During the process, the clamping rod 1703 drives the adjacent limiting column 1705 and the adjacent fourth elastic element 1708 to move together. After the limiting column 1705 moves to be separated from the adjacent transverse groove 17074, the transverse groove 17074 loses the limiting effect on the adjacent limiting column 1705. Subsequently, the two limiting columns 1705 in the same group begin to move backwards and enter the adjacent long vertical groove 17072 under the action of the elastic force of the adjacent fourth elastic element 1708. By further pressing the culture dish 101, the three clamping rods 1703 can quickly release the clamping of the culture dish 101, and the rubber pad on the clamping rod 1703 returns to its original state, thereby reducing the staff's additional operating steps and improving work efficiency.

[0029] After the three clamping rods 1703 clamp the culture dish 101, the staff member holds the culture dish 101 and moves upward, the second sliding column 1701 starts to move upward with the first elastic element 1702, and the first sliding column 1202 starts to move upward under the action of the elastic force of the adjacent third elastic element 1706, and the three first sliding columns 1202 jointly drive the cooling plate 13 to move upward together. During the upward movement of the second sliding column 1701, the limiting column 1705 is equivalent to sliding downward in the adjacent long vertical groove 17072, and then the limiting column 1705 passes over the adjacent one-way plate 1709 and enters the adjacent inclined groove 17071, the middle plate 1201 and all parts thereon are reset, and then the staff member takes out the culture dish 101 for storage, and finally controls the switch of the second motor 1501 through the intelligent monitoring center 3 to reset the second moving rod 1506 and the parts thereon (the next time it is used, the external medium filling device is used to fill the two storage shells 1407 with glucose and oxygen respectively).

[0030] In Example 1, the rotating plate 11 is fixedly connected to the middle plate 1201, the connecting frame 1401 is fixedly connected to the shell 2, the connecting frame 1401 is fixedly connected to the middle piece 1402, and the first ring 1405 and the second ring 1406 are both fixedly connected to the middle piece 1402. In Example 2, the rotating plate 11 is rotatably connected to the middle plate 1201, the connecting frame 1401 is slidably connected to the shell 2, the connecting frame 1401 is rotatably connected to the middle piece 1402, and the first ring 1405 and the second ring 1406 are both rotatably connected to the middle piece 1402, so that glucose can enter the culture dish 101 evenly, thereby increasing the uniformity of contact between tumor cells and glucose and improving the detection effect.

[0031] Embodiment 2: Based on embodiment 1, Figure 8 and Fig.10 As shown, it also includes an extrusion mechanism for moving the connecting frame 1401, and the extrusion mechanism is arranged in the shell 2. The extrusion mechanism includes two elastic telescopic rods 1801 arranged symmetrically on the left and right. The two elastic telescopic rods 1801 are fixed to the lower side of the first piston plate 9, the rotating plate 11 is rotatably connected to the middle plate 1201, the connecting frame 1401 is slidably connected to the shell 2, the connecting frame 1401 is rotatably connected to the middle piece 1402, the first ring 1405 and the second ring 1406 are rotatably connected to the middle piece 1402, the telescopic ends of the two elastic telescopic rods 1801 are fixed to the connecting frame 1401, and two fifth elastic elements 1802 arranged symmetrically on the left and right are fixed between the connecting frame 1401 and the shell 2. The fifth elastic element 1802 is elastic rubber and is used to reset the connecting frame 1401.

[0032] like Figure 3 and Figure 8-Figure 10As shown, the output shaft of the first motor 10 is located at an eccentric position of the rotating plate 11, and a second gear ring 1901 is fixedly connected to the lower side of the shell 2, and a third gear ring 1902 meshing with the second gear ring 1901 is fixedly connected to the outer side of the middle plate 1201, which is used to make the third gear ring 1902 roll around the second gear ring 1901, so that the culture dish 101 rotates, thereby increasing the number of points where glucose enters the culture dish 101, improving the degree of dispersion of glucose in the culture dish 101, and ensuring the nutrient supply of tumor cells. The output shaft of the first motor 10 is fixedly connected to a fixed rod 2001, and the fixed rod 2001 is slidably matched with the middle piece 1402. When the fixed rod 2001 rotates, the middle piece 1402 is driven to rotate together, thereby further increasing the number of points where glucose enters the culture dish 101, and an absorbent 2002 is detachably installed on the upper part of the left side of the fixed rod 2001. The absorbent 2002 contains a medium capable of absorbing water vapor and carbon dioxide, such as activated carbon.

[0033] In order to further improve the dispersion of glucose in the culture dish 101, the third gear ring 1902 is used to roll along the second gear ring 1901 so that the culture dish 101 rotates counterclockwise (in the top view) during the clockwise rotation around the axis of the output shaft of the first motor 10. At the same time, the fixing rod 2001 drives the middle piece 1402 to rotate clockwise, so that the glucose solution from the first channel 1403 enters the culture dish 101 at different positions, thereby increasing the uniformity of contact between tumor cells and glucose, thereby ensuring that the tumor cells have sufficient nutrients for proliferation. The specific steps are as follows: during the clockwise rotation of the middle plate 1201, the middle plate 1201 drives the third gear ring 1902 to rotate clockwise together. During the process, the third gear ring 1902 rolls along the second gear ring 1901, that is, The middle plate 1201 rotates counterclockwise, and the middle plate 1201 drives the parts thereon and the culture dish 101 to rotate counterclockwise. At the same time, the output shaft of the first motor 10 drives the fixed rod 2001 to rotate clockwise, and the fixed rod 2001 drives the middle piece 1402 to rotate clockwise. The first ring 1405 and the second ring 1406 slide relative to the middle piece 1402. After the glucose solution flows out of the first channel 1403, the glucose solution enters the culture dish 101 at multiple points, thereby increasing the dispersion of glucose in the culture dish 101, thereby making the tumor cells evenly contact with the glucose, so that the tumor cells have sufficient nutrients to proliferate, and preventing some tumor cells from accidentally dying due to lack of contact with glucose, thereby reducing the accuracy of the tumor cell resistance detection results.

[0034] In order to improve the accuracy of the tumor cell resistance test results and prevent the carbon dioxide and moisture produced by the aerobic respiration of tumor cells from affecting the normal detection process, the two elastic telescopic rods 1801 jointly drive the connecting frame 1401 to move downward, and the fixed rod 2001 drives the absorbent 2002 to rotate together, thereby changing the evaporation rate of the moisture in the culture dish 101, and absorbing the carbon dioxide and water vapor in the detection environment, so as to ensure the stability of the detection environment. The specific steps are as follows: during the downward movement of the first piston plate 9, the first piston plate 9 drives the two elastic telescopic rods 1801 to move downward together, and the two elastic telescopic rods 1801 jointly drive the connecting frame 1401 and the parts thereon to move downward together. During the process, the elastic telescopic rods 1801 are compressed, and the fifth elastic element 1802 is compressed, so that the air outlet pipe 16 is close to the culture dish 101, thereby accelerating the evaporation of the extra moisture in the culture dish 101 (the deeper the deep sea, the greater the pressure and the lower the temperature, so the ventilation volume is changed to change the evaporation rate of water).

[0035] During the clockwise rotation of the fixed rod 2001, the fixed rod 2001 drives the absorber 2002 to rotate clockwise together, and uses the solid sodium hydroxide in the absorber 2002 to absorb water vapor and carbon dioxide in the nearby area, so as to ensure that the components in the detection environment are relatively stable and improve the effect of tumor cell resistance detection. When the detection is completed and the first piston plate 9 moves upward, the two elastic telescopic rods 1801 are gradually reset, the connecting frame 1401 and the parts thereon are reset together, and the two fifth elastic elements 1802 are also reset.

[0036] The above are only further embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical solutions and concepts of the present invention within the scope disclosed by the present invention, which belong to the protection scope of the present invention.

Claims

1. A tumor drug resistance detection device based on artificial intelligence, comprising a base frame (1), the base frame (1) being fixedly connected to a shell (2), an intelligent monitoring center (3) being installed on the base frame (1), a flip cover (4) being hingedly connected to the shell (2), the shell (2) and the flip cover (4) being both provided with observation windows, a recording lens (5) electrically connected to the intelligent monitoring center (3) being installed at the observation window of the flip cover (4), a hydraulic push rod (6) being installed on a side of the shell (2) away from the base frame (1), a cross bar (7) being fixedly connected to the telescopic end of the hydraulic push rod (6), and a first moving rod (8) being fixedly connected to one end of the cross bar (7) away from the hydraulic push rod (6), wherein: The invention also comprises a first piston plate (9), the first piston plate (9) being fixedly connected to one end of the first moving rod (8) close to the base frame (1), the first piston plate (9) being sealingly and slidably connected to the shell (2), the base frame (1) being mounted with a first motor (10), the output shaft of the first motor (10) being sealingly and rotatably connected to the shell (2), the output shaft of the first motor (10) being fixedly connected to a rotating plate (11), a middle plate (1201) being arranged on a side of the rotating plate (11) away from the first motor (10), the middle plate (1201) being slidably connected to a first sliding column (1202) in an annular array, the first sliding columns (1202) in the annular array being jointly mounted with a cooling plate (13) electrically connected to the intelligent monitoring center (3), an adding mechanism for adding materials being arranged in the shell (2), and a clamping mechanism for clamping the detection dish being arranged in the middle of the middle plate (1201).

2. The device for detecting tumor drug resistance based on artificial intelligence according to claim 1, characterized in that: The adding mechanism comprises a connecting frame (1401), the connecting frame (1401) being arranged in the housing (2), the connecting frame (1401) being provided with an intermediate piece (1402), the intermediate piece (1402) being provided with a first channel (1403) and a second channel (1404), both the first channel (1403) and the second channel (1404) being provided with a one-way valve, the outer side of the intermediate piece (1402) being provided with a first ring (1405) and a second ring (1406), the bottom frame (1) being fixedly connected with symmetrically arranged storage shells (1407), the symmetrically arranged storage shells (1407) being filled with The storage shells (1407) are filled with nutrient medium and oxidizing medium, and the symmetrically arranged storage shells (1407) are respectively connected to external medium filling devices. An intermediate tube (1408) is connected between the first channel (1403) and the storage shell (1407) filled with nutrient medium, and between the second channel (1404) and the storage shell (1407) filled with oxidizing medium. The first ring (1405) and the second ring (1406) are respectively fixed to the adjacent intermediate tubes (1408). A power component for discharging the medium of the symmetrically arranged storage shells (1407) is provided on a side of the shell (2) away from the base frame (1).

3. The device for detecting tumor drug resistance based on artificial intelligence according to claim 2, characterized in that: The power assembly comprises a second motor (1501), the second motor (1501) being mounted on a side of the housing (2) away from the base frame (1), the output shaft of the second motor (1501) being fixedly connected to a first gear (1502), the storage shells (1407) being symmetrically arranged and being fixedly connected to mounting frames (1503), the mounting frames (1503) being rotatably connected to a second gear (1504), the side of the housing (2) close to the first gear (1502) being rotatably connected to a first gear ring (1505), the first gear (1502) and The symmetrically arranged second gears (1504) are meshed with the first gear ring (1505); the storage shell (1407) is slidably connected to a second moving rod (1506); the second moving rod (1506) is provided with a first limiting groove (1507); a protrusion that cooperates with the adjacent first limiting groove (1507) is fixedly connected in the second gear (1504); a second piston plate (1508) is sealingly slidably connected in the storage shell (1407); the second piston plate (1508) is fixedly connected to the adjacent second moving rod (1506).

4. The device for detecting tumor drug resistance based on artificial intelligence according to claim 3 is characterized in that: The first limiting groove (1507) is a spiral groove, and the pitch of the first limiting groove (1507) changes gradually, so as to enable the adjacent second piston plate (1508) to move at a variable speed.

5. The device for detecting tumor drug resistance based on artificial intelligence according to claim 2, characterized in that: An air outlet pipe (16) is fixedly connected to one side of the middle piece (1402) close to the base frame (1), and the air outlet pipe (16) is in communication with the second channel (1404).

6. The device for detecting tumor drug resistance based on artificial intelligence according to claim 1, characterized in that: The clamping mechanism comprises a second sliding column (1701), the second sliding column (1701) is slidably connected to the middle plate (1201), a first elastic element (1702) is fixedly connected between the second sliding column (1701) and the middle plate (1201), the middle plate (1201) is slidably connected to a ring-shaped array of clamping rods (1703), a second elastic element (1704) is fixedly connected between the clamping rods (1703) and the middle plate (1201), and opposite ends of the ring-shaped array of clamping rods (1703) are slidably connected to The limiting columns (1705) are symmetrically arranged, a third elastic element (1706) is fixedly connected between the first sliding column (1202) and the middle plate (1201), the second sliding column (1701) is provided with a second limiting groove (1707) in a ring array and symmetrically arranged, the second limiting groove (1707) is limitedly matched with adjacent limiting columns (1705), a fourth elastic element (1708) is fixedly connected between adjacent and symmetrically arranged limiting columns (1705), and a one-way plate (1709) is fixedly connected in the second limiting groove (1707).

7. The device for detecting tumor drug resistance based on artificial intelligence according to claim 6, characterized in that: The second limiting groove (1707) is composed of an oblique groove (17071), a long vertical groove (17072), a transverse groove (17074) and a short vertical groove (17073) connected end to end, and the distance between the adjacent and symmetrically arranged short vertical grooves (17073) gradually increases from one side close to the cooling plate (13) to the other side, and the groove depth of the transverse groove (17074) is smaller than the groove depth of the adjacent long vertical groove (17072).

8. The device for detecting tumor drug resistance based on artificial intelligence according to claim 2, characterized in that: The invention also comprises an extrusion mechanism for moving the connecting frame (1401), the extrusion mechanism being arranged in the shell (2), the extrusion mechanism comprising an elastic telescopic rod (1801), the elastic telescopic rod (1801) being fixedly connected to a side of the first piston plate (9) away from the first moving rod (8), the rotating plate (11) being rotatably connected to the intermediate plate (1201), the connecting frame (1401) being slidably connected to the shell (2), the connecting frame (1401) being rotatably connected to the intermediate piece (1402), the first ring (1405) and the second ring (1406) being rotatably connected to the intermediate piece (1402), the telescopic end of the elastic telescopic rod (1801) being fixedly connected to the connecting frame (1401), and a symmetrically arranged fifth elastic element (1802) being fixedly connected between the connecting frame (1401) and the shell (2).

9. The artificial intelligence-based tumor drug resistance detection device according to claim 8, characterized in that: The output shaft of the first motor (10) is located at an eccentric position of the rotating plate (11); a second gear ring (1901) is fixedly connected to a side of the housing (2) close to the base frame (1); a third gear ring (1902) is fixedly connected to the outer side of the intermediate plate (1201); and the third gear ring (1902) meshes with the second gear ring (1901).

10. The device for detecting tumor drug resistance based on artificial intelligence according to claim 9, characterized in that: The output shaft of the first motor (10) is fixedly connected to a fixing rod (2001), the fixing rod (2001) is slidably matched with the intermediate component (1402), and an absorbing component (2002) is installed on a side of the fixing rod (2001) away from the first motor (10).

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