Aqueous system for improving stability of EUK-134 and application of aqueous system in preparation of cosmetics

Abstract

The invention relates to the technical field of cosmetics, and particularly discloses a water-based system for improving EUK-134 stability and application of the water-based system in preparation of cosmetics. The water-based system for improving the stability of the EUK-134 is prepared from the EUK-134, hydroxytyrosol, 1, 3-butanediol and water. Most preferably, in the aqueous system, the mass percentages of EUK-134, hydroxytyrosol, 1, 3-butanediol and water are as follows: 0.1% of EUK-134, 0.1% of hydroxytyrosol, 0.1% of 1, 3-butanediol and the balance of water. 2% of hydroxytyrosol; 20% of 1, 3-butanediol; and 77.9% of water. Researches show that hydroxytyrosol, 1, 3-butanediol and EUK-134 are added into water together to prepare a water-based system; and the stability is greatly higher than that of an EUK-134 aqueous solution.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, and in particular to an aqueous system for improving the stability of EUK-134 and an application thereof in preparing cosmetics. Background Art

[0002] EUK-134 is a synthetic antioxidant ingredient, and its Chinese name is ethylbisimidomethylguaiacol manganese chloride. Due to its excellent antioxidant ability, it is sought after by many beauty brands. However, EUK-134 is unstable in aqueous solution and will decompose and fade. In particular, EUK-134 will begin to decompose and fade when the temperature exceeds 45°C for 30 minutes.

[0003] Due to the instability of EUK-134 in water, it is difficult for EUK-134 to be widely used in the cosmetics industry. Currently, EUK-134 can basically only be made into freeze-dried powder in the cosmetics field, which greatly limits the application of EUK-134 in the cosmetics field.

[0004] Therefore, providing a technology for improving the stability of EUK-134 in water has important application value for broadening the application of EUK-134 in the field of cosmetics. Summary of the invention

[0005] In order to overcome at least one of the technical problems existing in the prior art, the present invention first provides an aqueous system for improving the stability of EUK-134 and its application in the preparation of cosmetics.

[0006] The above technical problems to be solved by the present invention are achieved through the following technical solutions:

[0007] The present invention firstly provides an aqueous system for improving the stability of EUK-134, which comprises EUK-134, hydroxytyrosol, 1,3-butanediol and water.

[0008] The inventors surprisingly found in their research that the stability of the aqueous system prepared by adding hydroxytyrosol and 1,3-butanediol together with EUK-134 into water is much higher than the stability of EUK-134 in water.

[0009] The inventors also found in the study that the stability of the aqueous system prepared by adding hydroxytyrosol, 1,3-butanediol and EUK-134 to water is also much higher than that of the aqueous system prepared by adding only hydroxytyrosol or only 1,3-butanediol and EUK-134 to water; adding hydroxytyrosol, 1,3-butanediol and EUK-134 to water at the same time can synergistically improve the stability of EUK-134 in water.

[0010] Preferably, in the aqueous system, the mass percentage of EUK-134 is 0.05-0.15%.

[0011] Most preferably, in the aqueous system, the mass percentage of EUK-134 is 0.1%.

[0012] Preferably, in the aqueous system, the mass percentage of hydroxytyrosol is 0.5-3%.

[0013] Most preferably, in the aqueous system, the mass percentage of hydroxytyrosol is 2%.

[0014] Preferably, in the aqueous system, the mass percentage of 1,3-butanediol is 15-25%.

[0015] Most preferably, in the aqueous system, the mass percentage of 1,3-butanediol is 20%.

[0016] Preferably, the mass percentage of water is 75-80%.

[0017] Most preferably, in the aqueous system, the mass percentages of EUK-134, hydroxytyrosol, 1,3-butanediol and water are respectively: EUK-134 0.1%; hydroxytyrosol 2%; 1,3-butanediol 20%; water 77.9%.

[0018] The inventors found in further research that the amount of hydroxytyrosol and 1,3-butanediol used has an important influence on the stability of the prepared aqueous system; when hydroxytyrosol and 1,3-butanediol are respectively used at the above mass percentages to obtain an aqueous system, its stability is significantly higher than that of an aqueous system obtained at other mass percentages.

[0019] The present invention also provides an application of the aqueous system for improving the stability of EUK-134 in the preparation of cosmetics.

[0020] Preferably, the cosmetics are moisture-containing cosmetics.

[0021] Beneficial effects: The present invention provides a new aqueous system for improving the stability of EUK-134. Studies have shown that the aqueous system prepared by adding hydroxytyrosol and 1,3-butanediol together with EUK-134 into water has a much higher stability than the aqueous solution of EUK-134. The aqueous system containing EUK-134 prepared by the present invention can greatly improve the stability of EUK-134 in water. Therefore, the aqueous system for improving the stability of EUK-134 described in the present invention is applied to the field of cosmetics, which can broaden the dosage form of cosmetics containing EUK-134 and realize the application of EUK-134 in the preparation of cosmetics containing water, and has important application value. DETAILED DESCRIPTION

[0022] The present invention is further explained below in conjunction with specific examples, but the examples do not limit the present invention in any form.

[0023] Example 1 Aqueous system to improve the stability of EUK-134

[0024] Composition by mass percentage: EUK-134 0.1%; Hydroxytyrosol 2%; 1,3-Butanediol 20%; Water 77.9%.

[0025] Preparation method: EUK-134, hydroxytyrosol and 1,3-butanediol are added into water and stirred evenly to obtain the aqueous system for improving the stability of EUK-134.

[0026] Example 2 Aqueous system to improve the stability of EUK-134

[0027] Composition by mass percentage: EUK-134 0.1%; Hydroxytyrosol 0.5%; 1,3-Butanediol 25%; Water 74.4%.

[0028] Preparation method: EUK-134, hydroxytyrosol and 1,3-butanediol are added into water and stirred evenly to obtain the aqueous system for improving the stability of EUK-134.

[0029] Example 3 Aqueous system to improve the stability of EUK-134

[0030] Composition by mass percentage: EUK-134 0.1%; Hydroxytyrosol 3%; 1,3-Butanediol 15%; Water 81.9%.

[0031] Preparation method: EUK-134, hydroxytyrosol and 1,3-butanediol are added into water and stirred evenly to obtain the aqueous system for improving the stability of EUK-134.

[0032] Comparative Example 1EUK-13 Water-based System

[0033] Composition by mass percentage: EUK-134 0.1%; water 99.9%.

[0034] Preparation method: Add EUK-134 into water and stir evenly to obtain the aqueous system.

[0035] Comparative Example 2 Aqueous system for improving the stability of EUK-134

[0036] Composition by mass percentage: EUK-134 0.1%; 1,3-butanediol 20%; water 79.9%.

[0037] Preparation method: EUK-134 and 1,3-butanediol are added into water, and stirred evenly to obtain the aqueous system for improving the stability of EUK-134.

[0038] Comparative Example 3 Aqueous system for improving the stability of EUK-134

[0039] Composition by mass percentage: EUK-134 0.1%; Hydroxytyrosol 2%; Water 97.9%.

[0040] Preparation method: EUK-134 and hydroxytyrosol are added into water, and stirred evenly to obtain the aqueous system for improving the stability of EUK-134.

[0041] Experimental example: Stability test

[0042] Accelerated testing examines the stability of cosmetics under conditions of temperature and humidity higher than long-term storage conditions. It provides a basis for formula and process design, and determines whether cosmetics can maintain stable quality when conditions deviate from actual storage conditions. It also provides a preliminarily predicted quality retention trend of cosmetics under specified storage conditions.

[0043] The accelerated stability test steps of this experiment are as follows: the samples are stored in a sealed clean container, and then placed in an incubator pre-adjusted to 45°C ± 2°C, 75% RH ± 5% RH for 60 days. Samples are taken at five time points (7th, 14th, 28th, 42nd, and 56th days). After returning to room temperature, they are observed and tested according to standards.

[0044] The aqueous systems for improving the stability of EUK-134 prepared in Examples 1 to 3 and Comparative Examples 2 to 3, and the aqueous system prepared in Comparative Example 1 were subjected to an accelerated stability test (45°C) to observe whether the colors of the aqueous systems after different acceleration times faded compared with the freshly prepared aqueous system at 0 days; the experimental results are shown in Table 1.

[0045] Table 1. Stability test results

[0046]

[0047] It can be seen from the experimental results in Table 1 that the aqueous system prepared in Comparative Example 1 is extremely unstable; however, the aqueous system prepared in Example 1 for improving the stability of EUK-134 did not fade after 56 days of accelerated experiment; this shows that the aqueous system prepared by adding hydroxytyrosol and 1,3-butanediol together with EUK-134 into water can greatly improve the stability of EUK-134 in water.

[0048] It can be seen from the experimental results in Table 1 that the aqueous system for improving the stability of EUK-134 prepared in Example 1 is also much more stable than the aqueous systems for improving the stability of EUK-134 prepared in Comparative Examples 2 and 3. This shows that the degree of improvement in the stability of EUK-134 in water by adding only hydroxytyrosol or only 1,3-butanediol and EUK-134 to water is much lower than that by adding hydroxytyrosol and 1,3-butanediol to water at the same time; adding hydroxytyrosol and 1,3-butanediol to water at the same time can synergistically improve the stability of EUK-134 in water.

[0049] It can be seen from the experimental results in Table 1 that the aqueous system for improving the stability of EUK-134 prepared in Example 1 is also significantly more stable than the aqueous systems for improving the stability of EUK-134 prepared in Examples 2 and 3; this shows that the amount of hydroxytyrosol and 1,3-butanediol has an important influence on the stability of the prepared aqueous system; when hydroxytyrosol and 1,3-butanediol are respectively used at the mass percentages described in Example 1, the stability of the aqueous system is significantly higher than that of the aqueous systems obtained at other mass percentages.

Claims

1. A water-based system for improving the stability of EUK-134, It is characterized in that Contains EUK-134, Hydroxytyrosol, 1,3-Butylene Glycol and Water.

2. The aqueous system for improving the stability of EUK-134 according to claim 1, It is characterized in that In the aqueous system, the mass percentage of EUK-134 is 0.05-0.15%.

3. The aqueous system for improving the stability of EUK-134 according to claim 1, It is characterized in that In the aqueous system, the mass percentage of EUK-134 is 0.1%.

4. The aqueous system for improving the stability of EUK-134 according to claim 1, It is characterized in that In the aqueous system, the mass percentage of hydroxytyrosol is 0.5-3%.

5. The aqueous system for improving the stability of EUK-134 according to claim 1, It is characterized in that In the aqueous system, the mass percentage of hydroxytyrosol is 2%.

6. The aqueous system for improving the stability of EUK-134 according to claim 1, It is characterized in that In the aqueous system, the mass percentage of 1,3-butanediol is 15-25%.

7. The aqueous system for improving the stability of EUK-134 according to claim 1, It is characterized in that In the aqueous system, the mass percentage of 1,3-butanediol is 20%.

8. The aqueous system for improving the stability of EUK-134 according to claim 1, It is characterized in that In the aqueous system, the mass percentage of water is 75-80%.

9. The aqueous system for improving the stability of EUK-134 according to claim 1, It is characterized in that In the aqueous system, the mass percentages of EUK-134, hydroxytyrosol, 1,3-butanediol and water are respectively: EUK-134 0.1%; hydroxytyrosol 2%; 1,3-butanediol 20%; and water 77.9%.

10. Use of the aqueous system for improving the stability of EUK-134 according to any one of claims 1 to 9 in the preparation of cosmetics.

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