Anti-wrinkle composition, anti-wrinkle essence and application of anti-wrinkle composition and anti-wrinkle essence

Abstract

The invention provides an anti-wrinkle composition, anti-wrinkle essence and application of the anti-wrinkle composition and the anti-wrinkle essence, and belongs to the technical field of cosmetics. The anti-wrinkle composition disclosed by the invention is prepared from the following components in parts by mass: 1 to 3 parts of yeast extract and 3 to 8 parts of acetyl hexapeptide-8. The yeast extract and the acetyl hexapeptide-8 are synergistically matched, so that the inhibition rate on elastinase can be increased, wrinkles on facial skin, scalp skin and neck skin can be reduced or the wrinkles can be prevented, the skin elasticity can be recovered, the collagen strength can be improved, and the skin barrier function and the hydration moisturizing effect can be improved. The anti-wrinkle active composition provided by the invention can be used for preparing face and neck care products with anti-wrinkle and anti-aging effects.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to an anti-wrinkle composition and an anti-wrinkle essence and applications thereof. Background Art

[0002] The characteristics of skin aging are: sagging, roughness, wrinkle formation, pigmentation disorder, etc. Among them, the cause of skin wrinkles is mainly related to the progressive atrophy of the dermis. The dermis is mainly composed of extracellular matrix and fibroblasts. During the aging process, collagen and elastic fibers, which are the main components of the extracellular matrix, become fragmented and the total amount decreases, causing wrinkles. There are many types of collagen, which are the structure and support of tissues such as bones, ligaments, corneas, and blood vessel walls. Among them, type I collagen accounts for about 85% of the total collagen in the human body. It is also the most abundant protein in vertebrates and plays a key role in the firmness and elasticity of the skin. Elastin is the main component of elastic fibers. Although elastin only accounts for about 2% of the total protein in the dermis, it plays an important role in skin elasticity. The reduction of elastin in the skin is the main cause of sagging, sagging and fine wrinkles caused by skin aging. Therefore, continuously supplementing or improving the synthesis of collagen and elastin is an effective way to fight aging and wrinkle formation.

[0003] Acetyl Hexapeptide-8 is a neurotransmitter inhibitory peptide that can inhibit the release of the neurotransmitter acetylcholine and reduce muscle contraction, thereby reducing the formation of dynamic lines and expression lines. Studies have shown that Acetyl Hexapeptide-8 can increase the synthesis of type I collagen, improve skin firmness and elasticity, and reduce the formation of wrinkles. However, the anti-wrinkle effect of adding Acetyl Hexapeptide-8 as the only active ingredient to cosmetics is not ideal. Summary of the invention

[0004] The purpose of the present invention is to provide an anti-wrinkle composition and an anti-wrinkle essence and their application, wherein yeast extract and acetyl hexapeptide-8 act synergistically to achieve a better anti-wrinkle effect, thereby solving the problem that acetyl hexapeptide-8 alone has an unsatisfactory anti-wrinkle effect.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The invention provides an anti-wrinkle composition, comprising the following components in parts by mass: 1 to 3 parts of yeast extract and 3 to 8 parts of acetyl hexapeptide-8.

[0007] Preferably, the anti-wrinkle composition further comprises a moisturizer, a soothing agent, an antioxidant and a whitening ingredient;

[0008] The soothing agent includes dipotassium glycyrrhizinate, and the mass fraction of the dipotassium glycyrrhizinate is 0.05 to 0.1 parts;

[0009] The whitening ingredient includes niacinamide; the mass fraction of the niacinamide is 0.08 to 0.15 parts;

[0010] The antioxidant comprises betaine and oat-β-glucan; the mass fraction of the betaine is 0.5 to 1 part, and the mass fraction of the oat-β-glucan is 0.4 to 0.8 part;

[0011] The moisturizing agent comprises the following components in parts by weight: 1 to 3 parts of butylene glycol, 1 to 3 parts of glycerol, 0.05 to 0.1 parts of sodium hyaluronate, 0.1 to 0.3 parts of allantoin and 1 to 3 parts of panthenol.

[0012] Preferably, the anti-wrinkle composition further comprises plant extracts, which include the following components in parts by weight: 0.8-2.2 parts of Sophora flavescens extract, 0.7-1.5 parts of Rhodiola rosea extract, 0.7-1.5 parts of Paeonia lactiflora extract, 0.5-1 parts of Astragalus membranaceus extract and 0.5-1 parts of Salvia miltiorrhiza extract.

[0013] The invention provides application of the anti-wrinkle composition in preparing skin care products.

[0014] Preferably, the anti-wrinkle composition is added in an amount of 0.04 to 0.3 g / mL in skin care products.

[0015] Preferably, the skin care product comprises a gel, a water solution, an essence, a lotion, a cream, an ointment or a mask.

[0016] The present invention also provides an anti-wrinkle essence, comprising the following components in percentage by weight:

[0017] Phase A: 0.05-0.1% disodium EDTA, 0.1-0.3% allantoin and 0.05-0.1% dipotassium glycyrrhizinate;

[0018] Phase B: 1-3% butylene glycol, 1-3% glycerin, 0.5-1% betaine, 0.4-0.8% oat-β-glucan, 0.05-0.1% sodium hyaluronate, 1-3% panthenol, 0.08-0.15% niacinamide, 0.8-1.2% p-hydroxyacetophenone, 0.6-2% 1,2-hexanediol and 0.1-0.2% xanthan gum;

[0019] Phase C: yeast extract 1-3%, acetyl hexapeptide-8: 3-8%, Sophora flavescens extract 0.8-2.2%, Rhodiola rosea extract 0.7-1.5%, Paeonia lactiflora extract 0.7-1.5%, Astragalus extract 0.5-1%, Salvia miltiorrhiza extract 0.5-1%;

[0020] The remaining amount of water.

[0021] The present invention also provides a method for preparing the anti-wrinkle essence, comprising the following steps:

[0022] (1) Mix phase A with water at 58-62° C., stir and keep warm for 25-35 minutes to obtain mixture 1;

[0023] (2) After the mixture 1 is cooled to 38-42°C, it is mixed with phase B and stirred to obtain a mixture 2;

[0024] (3) After the mixture 2 is cooled to 23-27° C., it is mixed with phase C and stirred to obtain the anti-wrinkle essence.

[0025] By adopting the above technical scheme, the present invention has the following beneficial effects: the anti-wrinkle composition of the present invention comprises the following components in parts by mass: 1 to 3 parts of yeast extract and 3 to 8 parts of acetyl hexapeptide-8. Yeast extract and acetyl hexapeptide-8 can improve the inhibition rate of elastase through synergistic cooperation, reduce wrinkles on facial skin, scalp skin and neck skin or prevent the formation of wrinkles, help restore skin elasticity, enhance collagen strength, enhance skin barrier function and hydration and moisturizing effects. The anti-wrinkle active composition provided by the present invention can be used to prepare facial and neck care products with anti-wrinkle and anti-aging effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is the elastase inhibition rate of each group of essence in Example 1. DETAILED DESCRIPTION

[0027] The invention provides an anti-wrinkle composition, comprising the following components in parts by mass: 1 to 3 parts of yeast extract and 3 to 8 parts of acetyl hexapeptide-8.

[0028] The mass fraction of the yeast extract is 1 to 3 parts, more preferably 1.5 to 2.5 parts, and more preferably 2 parts;

[0029] The mass fraction of the acetyl hexapeptide-8 is 3 to 8 parts, more preferably 5 to 7 parts, and more preferably 6 parts;

[0030] The anti-wrinkle composition of the present invention further comprises a moisturizer, a soothing agent, an antioxidant and a whitening component;

[0031] The soothing agent includes dipotassium glycyrrhizinate, and the mass fraction of the dipotassium glycyrrhizinate is 0.05 to 0.1 parts, more preferably 0.07 to 0.09 parts, and more preferably 0.08 parts;

[0032] The whitening ingredient includes niacinamide; the mass fraction of the niacinamide is 0.08 to 0.15 parts, more preferably 0.10 to 0.13 parts, and more preferably 0.12 parts;

[0033] The antioxidant comprises betaine and oat-β-glucan; the mass fraction of betaine is 0.5 to 1 part, more preferably 0.7 to 0.9 part, and more preferably 0.8 part; the mass fraction of oat-β-glucan is 0.4 to 0.8 part, more preferably 0.5 to 0.7 part, and more preferably 0.6 part;

[0034] The moisturizing agent comprises the following components in parts by weight: 1 to 3 parts of butylene glycol, 1 to 3 parts of glycerol, 0.05 to 0.1 parts of sodium hyaluronate, 0.1 to 0.3 parts of allantoin and 1 to 3 parts of panthenol;

[0035] The mass fraction of the butanediol is further preferably 1.5 to 2.5 parts, more preferably 2 parts;

[0036] The mass fraction of the glycerol is further preferably 1.5 to 2.5 parts, more preferably 2 parts;

[0037] The mass fraction of the sodium hyaluronate is further 0.07 to 0.09 parts, more preferably 0.08 parts;

[0038] The mass fraction of allantoin is further preferably 0.15 to 0.25 parts, more preferably 0.2 parts;

[0039] The mass fraction of panthenol is more preferably 1.5 to 2.5 parts, and more preferably 2 parts.

[0040] The anti-wrinkle composition of the present invention further comprises plant extracts, wherein the plant extracts comprise the following components in parts by weight: 0.8 to 2.2 parts of Sophora flavescens extract, 0.7 to 1.5 parts of Rhodiola rosea extract, 0.7 to 1.5 parts of Paeonia lactiflora extract, 0.5 to 1 parts of Astragalus membranaceus extract and 0.5 to 1 parts of Salvia miltiorrhiza extract;

[0041] The mass fraction of the Sophora flavescens extract is further preferably 1.2 to 1.8 parts, more preferably 1.5 parts;

[0042] The mass fraction of the Rhodiola rosea extract is further preferably 0.9 to 1.3 parts, more preferably 1.1 parts;

[0043] The mass fraction of the peony extract is further preferably 0.8 to 1.2 parts, more preferably 1 part;

[0044] The mass fraction of the astragalus extract is further preferably 0.7 to 0.9 parts, more preferably 0.8 parts;

[0045] The mass fraction of the Salvia miltiorrhiza extract is more preferably 0.7 to 0.9 parts, and more preferably 0.8 parts.

[0046] The present invention also provides application of the anti-wrinkle composition in preparing skin care products.

[0047] Preferably, the amount of the anti-wrinkle composition added to the skin care product is 0.04-0.3 g / mL, more preferably 0.1-0.2 g / mL, and more preferably 0.15 g / mL.

[0048] Preferably, the skin care product comprises a gel, a water solution, an essence, a lotion, a cream, an ointment or a mask.

[0049] The present invention also provides an anti-wrinkle essence, comprising the following components in percentage by weight:

[0050] Phase A: 0.05-0.1% disodium EDTA, 0.1-0.3% allantoin and 0.05-0.1% dipotassium glycyrrhizinate;

[0051] Phase B: 1-3% butylene glycol, 1-3% glycerin, 0.5-1% betaine, 0.4-0.8% oat-β-glucan, 0.05-0.1% sodium hyaluronate, 1-3% panthenol, 0.08-0.15% niacinamide, 0.8-1.2% p-hydroxyacetophenone, 0.6-2% 1,2-hexanediol and 0.1-0.2% xanthan gum;

[0052] Phase C: yeast extract 1-3%, acetyl hexapeptide-8: 3-8%, Sophora flavescens extract 0.8-2.2%, Rhodiola rosea extract 0.7-1.5%, Paeonia lactiflora extract 0.7-1.5%, Astragalus extract 0.5-1%, Salvia miltiorrhiza extract 0.5-1%;

[0053] The remaining amount of water.

[0054] The present invention also provides a method for preparing the anti-wrinkle essence, comprising the following steps: (1) mixing phase A with water at 58 to 62° C., stirring and keeping warm for 25 to 35 minutes to obtain a mixture 1;

[0055] (2) After the mixture 1 is cooled to 38-42°C, it is mixed with phase B and stirred to obtain a mixture 2;

[0056] (3) After the mixture 2 is cooled to 23-27° C., it is mixed with phase C and stirred to obtain the wrinkle essence.

[0057] In the present invention, phase A is mixed with water and then kept warm to obtain a mixture 1, wherein the temperature of the water is 58-62°C, preferably 59-61°C, and more preferably 60°C; the keeping time is 25-35min, more preferably 27-32min, and more preferably 30min; after the mixture 1 is cooled, it is mixed with phase B and stirred evenly to obtain a mixture 2; the temperature after the cooling is 38-42°C, more preferably 39-41°C, and more preferably 40°C; after the mixture 1 is cooled, it is mixed with phase C and stirred to obtain the wrinkle essence. The temperature after the cooling is 23-27°C, more preferably 24-26°C, and more preferably 25°C.

[0058] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0059] Example 1

[0060] Phase A: 0.05% disodium EDTA, 0.1% allantoin, and 0.05% dipotassium glycyrrhizinate;

[0061] Phase B: butylene glycol 1%, glycerin 1%, betaine 0.5%, oat-beta glucan 0.4%, sodium hyaluronate 0.05%, panthenol 1%, niacinamide 0.08%, p-hydroxyacetophenone 0.8%, 1,2-hexanediol 0.6% and xanthan gum 0.1%;

[0062] Phase C: 1% yeast extract, 3% acetyl hexapeptide-8, 0.8% Sophora flavescens extract, 0.7% Rhodiola rosea extract, 0.7% Peony extract, 0.5% Astragalus extract, 0.5% Salvia miltiorrhiza extract;

[0063] The remaining amount of water.

[0064] Preparation method: Mix phase A with 58°C water, stir and keep warm for 25 minutes to obtain mixture 1;

[0065] After the mixture 1 is cooled to 38°C, it is mixed with phase B and stirred to obtain a mixture 2;

[0066] After the mixture 2 is cooled to 23° C., it is mixed with phase C and stirred to obtain the anti-wrinkle essence.

[0067] Example 2

[0068] Phase A: 0.08% disodium EDTA, 0.2% allantoin, and 0.08% dipotassium glycyrrhizinate;

[0069] Phase B: Butylene glycol 2%, glycerin 2%, betaine 0.8%, oat-beta glucan 0.6%, sodium hyaluronate 0.08%, panthenol 2%, niacinamide 0.10%, parahydroxyacetophenone 1.0%, 1,2-hexanediol 1.2% and xanthan gum 0.15%;

[0070] Phase C: 2% yeast extract, 5% acetyl hexapeptide-8, 1.5% Sophora flavescens extract, 1.0% Rhodiola rosea extract, 1.0% Paeonia lactiflora extract, 0.8% Astragalus extract, 0.8% Salvia miltiorrhiza extract;

[0071] The remaining amount of water.

[0072] Preparation method: Mix phase A with 60°C water, stir and keep warm for 30 minutes to obtain mixture 1;

[0073] After the mixture 1 is cooled to 40°C, it is mixed with phase B and stirred to obtain a mixture 2;

[0074] After the mixture 2 is cooled to 25° C., it is mixed with phase C and stirred to obtain the anti-wrinkle essence.

[0075] Example 3

[0076] Phase A: 0.1% disodium EDTA, 0.3% allantoin, and 0.1% dipotassium glycyrrhizinate;

[0077] Phase B: butylene glycol 3%, glycerin 3%, betaine 1%, oat-beta glucan 0.8%, sodium hyaluronate 0.1%, panthenol 3%, niacinamide 0.15%, p-hydroxyacetophenone 1.2%, 1,2-hexanediol 2% and xanthan gum 0.2%;

[0078] Phase C: 3% yeast extract, 8% acetyl hexapeptide-8, 2.2% Sophora flavescens extract, 1.5% Rhodiola rosea extract, 1.5% Peony extract, 1% Astragalus extract, 1% Salvia miltiorrhiza extract;

[0079] The remaining amount of water.

[0080] Preparation method: Mix phase A with 62°C water, stir and keep warm for 35 minutes to obtain mixture 1;

[0081] After the mixture 1 is cooled to 42°C, it is mixed with phase B and stirred to obtain a mixture 2;

[0082] After the mixture 2 is cooled to 27° C., it is mixed with phase C and stirred to obtain the anti-wrinkle essence.

[0083] Comparative Example 1

[0084] Different from Example 2, yeast extract, Sophora flavescens extract, Rhodiola rosea extract, Paeonia lactiflora extract, Astragalus membranaceus extract and Salvia miltiorrhiza extract were not added.

[0085] Comparative Example 2

[0086] Different from Example 2, no yeast extract was added.

[0087] Comparative Example 3

[0088] The difference from Example 2 is that adenosine is used instead of yeast extract, and the amount of adenosine added is the same as the amount of yeast extract added in Example 2.

[0089] Comparative Example 4

[0090] The difference from Example 2 is that acetyl hexapeptide-8 is replaced by adenosine, and the amount of adenosine added is the same as the amount of acetyl hexapeptide-8 added in Example 2.

[0091] Comparative Example 5

[0092] Different from Example 2, acetyl hexapeptide-8 was not added.

[0093] Experimental Example 1 Elastase inhibition test

[0094] The principle of the elastase inhibition test is that elastase reacts with the enzyme substrate, and the absorbance changes after the active substance is added. The magnitude of the absorbance change can reflect the magnitude of the inhibition rate of the elastase inhibitor. Therefore, this test analyzes and evaluates the anti-wrinkle effect of the sample by inhibiting elastase by detecting the inhibition rate of the sample on elastase. The main reagents of the experiment are shown in Table 1.

[0095] Table 1 Experimental reagents

[0096]

[0097]

[0098] The anti-wrinkle essences of Example 2 and Comparative Examples 1 to 5 were used as test samples for testing, and the testing steps were as follows:

[0099] 1) Dilute the test sample with 0.2 M borate buffer solution to prepare the test sample solution.

[0100] 2) Add 100 μL of 2 mM Tris-HCl buffer solution, 10 μL of elastase solution and 30 μL of test sample solution (positive control is EGCG, blank control is Tris-HCl buffer solution) to a 96-well plate and mix well. Incubate at 25°C for 15 min in 3 replicate wells per group.

[0101] 3) 40 μL of substrate AAAPVN was added to each of the sample group and the control group, and the cells were incubated at 25°C for 20 min.

[0102] 4) The OD value was measured by an enzyme-labeled instrument at a wavelength of 405 nm.

[0103] The experimental results are shown in Table 2.

[0104] Table 2 Elastase inhibition rate of each group of essences

[0105]

[0106] As shown in Table 2, the essence prepared in Example 2 has a higher elastase inhibition rate of 39.78%, while the elastase inhibition rate of Comparative Example 1 is 24.01% without adding yeast extract; the elastase inhibition rate of Comparative Example 5 is 21.35% without adding acetyl hexapeptide-8. Adding yeast extract and acetyl hexapeptide-8 can improve the inhibition rate of the essence on elastase.

[0107] Experimental Example 2 Elastase Inhibition Rate of Raw Materials

[0108] The implementation method is the same as that of Experimental Example 1. The effective raw materials acetyl hexapeptide-8 and yeast extract are selected to prepare aqueous solutions of the same concentration.

[0109] Sample 1: Dissolve acetyl hexapeptide in purified water to a total volume of 100 mL;

[0110] Sample 2: Dissolve yeast extract in purified water to a total volume of 100 mL;

[0111] Sample 3: Take acetyl hexapeptide and yeast extract and dissolve them in purified water to a total volume of 100 mL.

[0112] Samples 1, 2, and 3 were taken for elastase inhibition experiments, and the experimental results are as follows:

[0113] Table 3 Elastase inhibition rate of functional raw materials

[0114]

[0115] From the above data, it can be seen that the inhibition rates of elastase in the aqueous solution of acetyl hexapeptide-8 and yeast extract are 22.04% and 11.74% respectively, while the inhibition rate of the complex of the two on elastase can reach 62.17%, indicating that the two have a synergistic effect on the inhibition of elastase after being compounded.

[0116] Experimental Example 3DPPH free radical scavenging experiment

[0117] Treatment of test substances: Refer to the addition amount requirements in Table 4, add the corresponding reagents into the sample tube, sample background tube, DPPH tube, and solvent background tube, and shake gently up and down until mixed evenly.

[0118] Table 4 Sample addition requirements

[0119]

[0120]

[0121] According to the sample addition requirements in Table 4, the free radical scavenging rate detection experiment was carried out. The specific operation was as follows: prepare a 5 mL centrifuge tube, add each reagent into the centrifuge tube, mix gently, let stand at room temperature for 5 minutes, transfer each reaction solution into a 96-well plate, and measure the absorbance at 517 nm.

[0122] The calculation formula for scavenging DPPH free radical activity is:

[0123]

[0124] Among them, T: sample tube measuring the absorbance value at 517nm, T0: sample background tube, C: DPPH tube, C0, solvent background tube.

[0125] The experimental results are shown in Table 5:

[0126] Table 5 DPPH clearance rate

[0127]

[0128] As can be seen from Table 5, in the detection of DPPH free radical scavenging rate, the scavenging rate of yeast extract for DPPH free radicals is 35.71%, and the scavenging rate of acetyl hexapeptide-8 for DPPH free radicals is 35.71%. However, after the two are compounded, the free radical scavenging rate is significantly improved to 51.46%, which is higher than the sum of the scavenging rates of the two for DPPH free radicals, indicating that yeast extract and acetyl hexapeptide-8 have a synergistic effect.

[0129] In summary, acetyl hexapeptide-8 and yeast extract can achieve certain anti-wrinkle effects in different detection directions, but the anti-wrinkle mechanisms may be different, resulting in different inhibition rates / clearance rates of different detection indicators. However, after the two are compounded, the effects are better than the effects of each raw material used alone.

[0130] It can be seen from the above examples that the present invention provides an anti-wrinkle composition and an anti-wrinkle essence and their application. The yeast extract and acetyl hexapeptide-8 of the present invention can improve the inhibition rate of elastase through synergistic cooperation, reduce wrinkles on facial skin, scalp skin and neck skin, or prevent the generation of wrinkles.

[0131] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An anti-wrinkle composition, characterized in that: The invention comprises the following components in parts by weight: 1 to 3 parts of yeast extract and 3 to 8 parts of acetyl hexapeptide-8.

2. An anti-wrinkle composition, characterized in that: It also includes moisturizers, soothing agents, antioxidants, and whitening ingredients; The soothing agent includes dipotassium glycyrrhizinate, and the mass fraction of the dipotassium glycyrrhizinate is 0.05 to 0.1 parts; The whitening ingredient includes niacinamide; the mass fraction of the niacinamide is 0.08 to 0.15 parts; The antioxidant comprises betaine and oat-β-glucan; the mass fraction of the betaine is 0.5 to 1 part, and the mass fraction of the oat-β-glucan is 0.4 to 0.8 part; The moisturizing agent comprises the following components in parts by weight: 1 to 3 parts of butylene glycol, 1 to 3 parts of glycerol, 0.05 to 0.1 parts of sodium hyaluronate, 0.1 to 0.3 parts of allantoin and 1 to 3 parts of panthenol.

3. The anti-wrinkle composition according to claim 2, characterized in that The anti-wrinkle composition also includes plant extracts, which include the following components in parts by weight: 0.8-2.2 parts of Sophora flavescens extract, 0.7-1.5 parts of Rhodiola rosea extract, 0.7-1.5 parts of Paeonia lactiflora extract, 0.5-1 parts of Astragalus membranaceus extract and 0.5-1 parts of Salvia miltiorrhiza extract.

4. Use of the anti-wrinkle composition according to any one of claims 1 to 3 in the preparation of skin care products.

5. The use according to claim 4, characterized in that: The anti-wrinkle composition is added in a skin care product in an amount of (0.04-0.3) g / mL.

6. The use according to claim 4, characterized in that: The skin care products include gel, lotion, essence, emulsion, cream, ointment or mask.

7. An anti-wrinkle essence, characterized in that: Contains the following components in percentage by mass: Phase A: 0.05-0.1% disodium EDTA, 0.1-0.3% allantoin and 0.05-0.1% dipotassium glycyrrhizinate; Phase B: 1-3% butylene glycol, 1-3% glycerin, 0.5-1% betaine, 0.4-0.8% oat-β-glucan, 0.05-0.1% sodium hyaluronate, 1-3% panthenol, 0.08-0.15% niacinamide, 0.8-1.2% p-hydroxyacetophenone, 0.6-2% 1,2-hexanediol and 0.1-0.2% xanthan gum; Phase C: yeast extract 1-3%, acetyl hexapeptide-8: 3-8%, Sophora flavescens extract 0.8-2.2%, Rhodiola rosea extract 0.7-1.5%, Paeonia lactiflora extract 0.7-1.5%, Astragalus extract 0.5-1%, Salvia miltiorrhiza extract 0.5-1%; The remaining amount of water.

8. The method for preparing the anti-wrinkle essence according to claim 7, characterized in that: The following steps are involved: (1) Mix phase A with water at 58-62° C., stir and keep warm for 25-35 minutes to obtain mixture 1; (2) After the mixture 1 is cooled to 38-42°C, it is mixed with phase B and stirred to obtain a mixture 2; (3) After the mixture 2 is cooled to 23-27° C., it is mixed with phase C and stirred to obtain the anti-wrinkle essence.

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