Honeysuckle flower and mango granules and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to honeysuckle flower and mango granules and a preparation method thereof. The invention provides honeysuckle flower and mango granules, which are prepared from the following components in parts by weight: 10 to 30 parts of honeysuckle flowers, 10 to 20 parts of mango leaves, 5 to 15 parts of herba taraxaci, 5 to 15 parts of radix platycodonis, 5 to 15 parts of radix stemonae, 5 to 15 parts of pericarpium citri reticulatae and 5 to 15 parts of liquorice roots. The honeysuckle flower and mango granules are obtained by combining the components and selecting a proper method to extract the effective components, mixing, granulating and the like. The granules have the effects of dispelling wind, clearing heat, relieving cough and reducing sputum, and are suitable for treating pharyngalgia, throat itching, cough and other symptoms caused by exogenous wind-heat.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to silver flower mango granules and a preparation method thereof. Background Art

[0002] Upper respiratory tract infection is a common disease, and its onset has obvious seasonality. If the treatment is not timely, it is easy to cause other symptoms. There are many drugs for treating upper respiratory tract infectious diseases on the market, mainly various antibiotics, and the pathogens that cause upper respiratory tract infection are mostly viruses. At present, general antibiotics have no obvious therapeutic effect on upper respiratory tract infection. If antibiotics are used too much, not only some toxic and side effects will be produced on the human body, but also "dysbacteriosis" will occur in the body, and the bacteria normally present in the human body will be killed by antibiotics, causing secondary infection. At the same time, upper respiratory tract infection will cause high fever. Conventional antipyretic western medicine may have slow antipyretic, or large body temperature fluctuations after antipyretic, and easy to rise again. By using Chinese medicine, the body is adjusted as a whole, and the drug effect is maintained for a long time, which is stable and not prone to rebound phenomenon. However, the existing Chinese medicine components need to be further strengthened in terms of active ingredient content and effect, and some preparation processes are relatively complicated, which are not suitable for industrial production, affecting the application. Summary of the invention

[0003] The invention aims to provide a method for preparing honeysuckle and mango granules, which mainly use honeysuckle, mango leaves, dandelions, platycodon, stemona, tangerine peel and liquorice as the main medicinal materials, and obtain the honeysuckle and mango granules by grouping and performing effective component extraction, mixing, granulation and other processes. The granules have the effects of dispelling wind and heat, relieving cough and reducing phlegm, and are suitable for treating symptoms such as pharyngitis, itchy throat and cough caused by exogenous wind-heat.

[0004] In order to achieve the above object, the present invention provides the following technical solutions:

[0005] A honeysuckle and mango granule, characterized by comprising the following components: 10-30 parts of honeysuckle, 10-20 parts of mango leaves, 5-15 parts of dandelions, 5-15 parts of platycodon, 5-15 parts of stemonae, 5-15 parts of tangerine peel, and 5-15 parts of liquorice.

[0006] Furthermore, the following components are included in parts by weight: 25 parts of honeysuckle, 16 parts of mango leaves, 12 parts of dandelions, 11 parts of platycodon, 10 parts of stemona, 12 parts of tangerine peel, and 10 parts of liquorice.

[0007] A method for preparing silver flower mango granules comprises the following steps:

[0008] S1: Take 10-30 parts of honeysuckle and 10-20 parts of mango leaves by weight, wash and remove impurities, dry at 80-90°C, crush, add deionized water at a solid-liquid ratio of 1:10-15, reflux and extract at 100-110°C for 3-5 times, each extraction for 1-3h, combine the extracts, filter the residue, centrifuge at 3000-4000r / min for 15-25min, and take the supernatant to obtain a mixed extract A;

[0009] S2: Taking 5-15 parts of dandelion, 5-15 parts of platycodon and 5-15 parts of stemona by weight, freeze-drying them at a pressure of 0.05-0.08 mbar and a temperature of -10°C--15°C for 35-55 min, cooling them to -30°C--40°C at a rate of 3-6°C / min, drying them for 1-3 h, and crushing them; adding n-butyl ether at a solid-liquid ratio of 1:15-25, extracting them at a temperature of 120-140°C for 2-4 h, centrifuging the extracted liquid at 2000-3000 r / min for 10-20 min, and filtering the supernatant to obtain a mixed extract B;

[0010] S3: taking 5-15 parts of dried tangerine peel and 5-15 parts of liquorice by weight, drying and crushing, adding ethanol at a solid-liquid ratio of 1:20-30, reflux extraction at a temperature of 80-100°C for 2-4 times, each extraction for 2-4 hours, combining the extracts, and drying in a constant temperature drying oven for 4-6 hours to obtain powder; extracting the above powder with carbon dioxide supercritical fluid, the extraction temperature is 40-60°C, the pressure is 30-50MPa, the flow rate of the supercritical carbon dioxide fluid is set to 280-350L / h, and after 3-5 hours of extraction, a mixed extract C is obtained;

[0011] S4: In parts by weight, the mixed extract A obtained in step S1, the mixed extract B in step S2, the mixed extract C obtained in step S3 and 30-50 parts of ethanol are stirred at a temperature of 60-70°C and a speed of 500-800r / min for 2-4h; then placed in a constant temperature drying oven and dried at 80-100°C for 4-6h; prepared into granules to obtain the silver flower mango granules.

[0012] Further, step S1 is optimized as follows: by weight, 15-25 parts of honeysuckle and 12-16 parts of mango leaves are taken, washed to remove impurities, dried at a temperature of 82-86°C, crushed, added with deionized water at a solid-liquid ratio of 1:12-14, refluxed and extracted at 105-110°C for 3-4 times, each extraction for 1.5-2.5h, the extracts are combined, the residue is filtered, and the supernatant is taken after centrifugation at a speed of 3500-4000r / min for 18-23min to obtain a mixed extract A.

[0013] Further, 22 parts of honeysuckle and 14 parts of mango leaves were taken by weight, washed to remove impurities, dried at 85°C, crushed, and refluxed at 108°C with a solid-liquid ratio of 1:13 for 3 times, each time for 2 hours, the extracts were combined, the residue was filtered, and the supernatant was taken after centrifugation at 3800r / min for 20 minutes to obtain a mixed extract A.

[0014] Further, step S2 is optimized as follows: by weight, 7-12 parts of dandelion, 10-14 parts of platycodon and 6-11 parts of stemona are freeze-dried at a pressure of 0.06-0.07 mbar and a temperature of -12°C--14°C for 40-50 min, cooled to -32°C--36°C at a rate of 4-6°C / min, dried for 1.5-2.5 h, and crushed; n-butyl ether is added thereto at a solid-liquid ratio of 1:18-22, extracted at a temperature of 130-140°C for 2.5-3.5 h, the extracted liquid is centrifuged at 2200-2600 r / min for 15-18 min, and the supernatant is filtered to obtain a mixed extract B.

[0015] Furthermore, 12 parts of dandelion, 11 parts of platycodon and 10 parts of stemona were freeze-dried at a pressure of 0.065 mbar and a temperature of -13°C for 50 min, cooled to -35°C at a rate of 5°C / min and dried for 2 h, and crushed; n-butyl ether was added thereto at a solid-liquid ratio of 1:22, extracted at a temperature of 135°C for 2.5 h, the extracted liquid was centrifuged at 2500 r / min for 16 min, and the supernatant was filtered to obtain a mixed extract B.

[0016] Further, step S3 is optimized as follows: by weight, 8-12 parts of dried tangerine peel and 9-14 parts of licorice are taken, dried and crushed, ethanol is added at a solid-liquid ratio of 1:22-26, reflux extraction is performed at a temperature of 85-95°C for 2-3 times, each extraction is for 2-3 hours, the extracts are combined, and the extracts are placed in a constant temperature drying oven for 4-5 hours to obtain powder; carbon dioxide supercritical fluid is used for extraction, the extraction temperature is 45-55°C, the pressure is 40-50MPa, the flow rate is 300-330L / h, and after 4-5 hours of extraction, a mixed extract C is obtained.

[0017] Furthermore, 10 parts of tangerine peel and 12 parts of licorice were taken by weight, dried and crushed, ethanol was added at a solid-liquid ratio of 1:24, refluxed and extracted at 90°C for 3 times, each time for 2 hours, the extracts were combined, and dried in a constant temperature drying oven for 4.5 hours to obtain powder; carbon dioxide supercritical fluid was used for extraction, the extraction temperature was 52°C, the pressure was 46MPa, the flow rate was 320L / h, and after 4.5 hours of extraction, a mixed extract C was obtained.

[0018] Further, step S4 is optimized as follows: in parts by weight, the mixed extract A obtained in step S1, the mixed extract B in step S2, the mixed extract C obtained in step S3 and 45 parts of ethanol are stirred at a temperature of 63°C and a rate of 750 r / min for 3.5 hours; then placed in a constant temperature drying oven and dried at 95°C for 4.5 hours; prepared into granules, and the silver flower mango granules can be obtained.

[0019] Compared with the prior art, the advantages and beneficial effects of the present invention are:

[0020] The present invention uses honeysuckle, mango leaves, dandelions, platycodon, stemona, tangerine peel and liquorice as main medicinal materials, combines the above ingredients respectively, and adopts corresponding extraction methods to better extract effective ingredients, improve the extraction efficiency and content of effective ingredients, and through the synergistic effect of each other, the prepared product particles have good effects of dispelling wind and heat, relieving cough and reducing phlegm, and are suitable for treating symptoms such as sore throat, itchy throat, cough and the like caused by exogenous wind-heat. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] Example 1

[0023] S1: Take 10g of honeysuckle and 10g of mango leaves, wash and remove impurities, dry at 80°C, crush, add deionized water at a solid-liquid ratio of 1:10, reflux extract at 100°C for 3 times, each extraction for 1h, combine the extracts, filter the residue, centrifuge at 3000r / min for 15min, and take the supernatant to obtain mixed extract A;

[0024] S2: Take 5g of dandelion, 5g of platycodon and 5g of stemona, freeze-dry at a pressure of 0.05mbar and a temperature of -10°C for 35min, cool to -30°C at a rate of 3°C / min, dry for 1h, and crush; add n-butyl ether at a solid-liquid ratio of 1:15, extract at a temperature of 120°C for 2h, centrifuge the extracted liquid at 2000r / min for 10min, and filter the supernatant to obtain a mixed extract B;

[0025] S3: Take 5g of dried tangerine peel and 5g of liquorice, dry and crush them, add ethanol at a solid-liquid ratio of 1:20, reflux and extract twice at a temperature of 80°C, each extraction for 2h, combine the extracts, put them in a constant temperature drying oven and dry them for 4h to obtain powder; use carbon dioxide supercritical fluid to extract the above powder, the extraction temperature is 40°C, the pressure is 30MPa, the flow rate is 280L / h, after 3h of extraction, obtain a mixed extract C;

[0026] S4: The mixed extract A obtained in step S1, the mixed extract B obtained in step S2, the mixed extract C obtained in step S3 and 30 g of ethanol are stirred at a temperature of 60°C and a rate of 500 r / min for 2 hours; then placed in a constant temperature drying oven and dried at 80°C for 4 hours; prepared into granules to obtain the silver flower mango granules.

[0027] Example 2

[0028] S1: Take 30g of honeysuckle and 20g of mango leaves, wash and remove impurities, dry at 90°C, crush, add deionized water at a solid-liquid ratio of 1:15, reflux extract at 110°C for 5 times, each extraction for 3h, combine the extracts, filter the residue, centrifuge at 4000r / min for 25min, and take the supernatant to obtain mixed extract A;

[0029] S2: Take 15g of dandelion, 15g of platycodon and 15g of stemona, freeze-dry at a pressure of 0.08mbar and a temperature of -15°C for 55min, cool to -40°C at a rate of 6°C / min, dry for 3h, and crush; add n-butyl ether at a solid-liquid ratio of 1:25, extract at a temperature of 140°C for 4h, centrifuge the extracted liquid at 3000r / min for 20min, and filter the supernatant to obtain a mixed extract B;

[0030] S3: Take 15g of dried tangerine peel and 15g of liquorice, dry them, crush them through a 80-120 mesh sieve, add ethanol solution at a solid-liquid ratio of 1:30, reflux and extract at a temperature of 100°C for 4 times, each extraction for 4 hours, combine the extracts, put them in a constant temperature drying oven and dry them for 6 hours to obtain powder; use carbon dioxide supercritical fluid to extract the above powder, the extraction temperature is 60°C, the pressure is 50MPa, the flow rate is 350L / h, after 5 hours of extraction, obtain a mixed extract C;

[0031] S4: The mixed extract A obtained in step S1, the mixed extract B obtained in step S2, the mixed extract C obtained in step S3 and 50 g of ethanol solution are stirred at a temperature of 70°C and a speed of 800 r / min for 4 hours; then placed in a constant temperature drying oven and dried at 100°C for 6 hours; prepared into granules to obtain the silver flower mango granules.

[0032] Example 3

[0033] S1: Take 15g of honeysuckle and 12g of mango leaves, wash and remove impurities, dry at 82°C, crush, add deionized water at a solid-liquid ratio of 1:12, reflux extract at 105°C for 3 times, each extraction for 1.5h, combine the extracts, filter the residue, centrifuge at 3500r / min for 18min, and take the supernatant to obtain mixed extract A;

[0034] S2: Take 7g of dandelion, 10g of platycodon and 6g of stemona, freeze-dry at a pressure of 0.065mbar and a temperature of -12°C for 40min, cool to -32°C at a rate of 4°C / min, dry for 1.5h, and crush to 100-120 mesh; add n-butyl ether at a solid-liquid ratio of 1:18, extract at a temperature of 130°C for 2.5h, centrifuge the extracted liquid at 2200r / min for 15min, take the supernatant and filter to obtain a mixed extract B.

[0035] S3: Take 8g of dried tangerine peel and 9g of liquorice, dry them and grind them through a 80-120 mesh sieve, add ethanol solution at a solid-liquid ratio of 1:22, reflux and extract twice at a temperature of 85°C, each extraction for 2h, combine the extracts, put them in a constant temperature drying oven and dry them for 4h to obtain powder; use carbon dioxide supercritical fluid for extraction, the extraction temperature is 45°C, the pressure is 40MPa, the flow rate is 300L / h, after 4h of extraction, obtain a mixed extract C;

[0036] S4: The mixed extract A obtained in step S1, the mixed extract B obtained in step S2, the mixed extract C obtained in step S3 and 37 g of ethanol solution are stirred at a temperature of 60°C and a speed of 650 r / min for 3 hours; then placed in a constant temperature drying oven and dried at 85°C for 4 hours; prepared into granules to obtain the silver flower mango granules.

[0037] Example 4

[0038] S1: Wash 25 g of honeysuckle and 16 g of mango leaves to remove impurities, dry at 86°C, crush, add deionized water at a solid-liquid ratio of 1:14, reflux extract at 110°C for 4 times, each extraction for 2.5 hours, combine the extracts, filter the residue, centrifuge at 4000 r / min for 18 minutes, and take the supernatant to obtain a mixed extract A;

[0039] S2: Take 12g of dandelion, 14g of platycodon and 11g of stemona, freeze-dry at a pressure of 0.06mbar and a temperature of -14°C for 50min, cool to -36°C at a rate of 6°C / min, dry for 2.5h, and crush to 100-120 mesh; add n-butyl ether at a solid-liquid ratio of 1:22, extract at a temperature of 140°C for 3.5h, centrifuge the extracted liquid at 2600r / min for 18min, and filter the supernatant to obtain a mixed extract B;

[0040] S3: Take 12g of dried tangerine peel and 14g of licorice, dry them, crush them through a 80-120 mesh sieve, add ethanol solution at a solid-liquid ratio of 1:26, reflux and extract at 95°C for 3 times, each time for 3 hours, combine the extracts, put them in a constant temperature drying oven and dry them for 5 hours to obtain powder; use carbon dioxide supercritical fluid for extraction, the extraction temperature is 55°C, the pressure is 50MPa, the flow rate is 330L / h, and after 5 hours of extraction, a mixed extract C is obtained;

[0041] S4: The mixed extract A obtained in step S1, the mixed extract B obtained in step S2, the mixed extract C obtained in step S3 and 47 g of ethanol solution are stirred at a temperature of 65°C and a rate of 800 r / min for 4 hours; then placed in a constant temperature drying oven and dried at 98°C for 5 hours; prepared into granules to obtain the silver flower mango granules.

[0042] Example 5

[0043] S1: Wash 22 g of honeysuckle and 14 g of mango leaves to remove impurities, dry at 85°C, crush, add deionized water at a solid-liquid ratio of 1:13, reflux extract at 108°C for 3 times, each extraction for 2 hours, combine the extracts, filter the residue, centrifuge at 3800 r / min for 20 minutes, and take the supernatant to obtain a mixed extract A;

[0044] S2: Take 12g of dandelion, 11g of platycodon and 10g of stemona, freeze-dry at a pressure of 0.07mbar and a temperature of -13°C for 50min, cool to -35°C at a rate of 5°C / min, dry for 2h, and crush to 100-120 mesh; add n-butyl ether at a solid-liquid ratio of 1:22, extract at a temperature of 135°C for 2.5h, centrifuge the extracted liquid at 2500r / min for 16min, and filter the supernatant to obtain a mixed extract B;

[0045] S3: Take 10g of dried tangerine peel and 12g of liquorice, dry them, crush them through a 80-120 mesh sieve, add ethanol solution at a solid-liquid ratio of 1:24, reflux and extract at 90°C for 3 times, each time for 2h, combine the extracts, put them in a constant temperature drying oven and dry them for 4.5h to obtain powder; use carbon dioxide supercritical fluid for extraction, the extraction temperature is 52°C, the pressure is 46MPa, the flow rate is 320L / h, and after 4.5h of extraction, a mixed extract C is obtained;

[0046] S4: The mixed extract A obtained in step S1, the mixed extract B obtained in step S2, the mixed extract C obtained in step S3 and 45 g of ethanol solution are stirred at a temperature of 63°C and a speed of 750 r / min for 3.5 h; then placed in a constant temperature drying oven and dried at 95°C for 4.5 h; prepared into granules to obtain the silver flower mango granules.

[0047] Comparative Example 1

[0048] The difference between this comparative example and Example 1 is that in step S1, extraction is performed under reflux at 100° C. for 1 hour, and the other steps are the same.

[0049] Comparative Example 2

[0050] The difference between this comparative example and Example 1 is that in step S1, extraction is performed under reflux at 100° C. for 6 times for 1 h, and the other steps are the same.

[0051] Comparative Example 3

[0052] The difference between this comparative example and Example 1 is that in step S2, no freeze-drying is performed, but n-butyl ether is added for extraction, and the other steps are the same.

[0053] Comparative Example 4

[0054] The difference between this comparative example and Example 1 is that no carbon dioxide supercritical fluid extraction treatment is used in step S3, and the other steps are the same.

[0055] Comparative Example 5

[0056] The difference between this comparative example and Example 1 is that the flow rate of the supercritical carbon dioxide fluid in step S3 is 50 L / h, and the other steps are the same.

[0057] Comparative Example 6

[0058] The difference between this comparative example and Example 1 is that the flow rate of the supercritical carbon dioxide fluid in step S3 is 400 L / h, and the other steps are the same.

[0059] Performance Testing:

[0060] The content of hesperidin was determined by high performance liquid chromatography (Appendix VI D of the first volume of the 2000 edition of the Chinese Pharmacopoeia); the chromatographic conditions were as follows: octadecylsilane bonded silica gel was used as a filler; methanol-acetic acid-water (35:4:61) was used as a mobile phase; and the detection wavelength was 283 nm. Stability test: The Yinhua Mango granules prepared in the examples and comparative examples were subjected to a 36-month long-term stability test of the active ingredients of the medicine.

[0061] The results are shown in the table below:

[0062] Table 1 Performance test results

[0063]

[0064]

[0065] From the above performance test results, it can be seen that the high hesperidin content and stability of Examples 1-5 are good. In particular, the comprehensive performance of Example 3 is the most outstanding. However, since the comparative example does not adopt the necessary technical solution, it is obviously inferior to the examples in the corresponding performance tests. The above experimental results further prove the importance of the technical solution defined in the present invention for its technical effect.

[0066] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A silver flower mango granule, characterized in that: The invention comprises the following components in parts by weight: 10-30 parts of honeysuckle, 10-20 parts of mango leaves, 5-15 parts of dandelions, 5-15 parts of platycodon, 5-15 parts of stemonae, 5-15 parts of tangerine peel and 5-15 parts of liquorice.

2. The silver flower mango granules according to claim 1, characterized in that: The invention comprises the following components by weight: 25 parts of honeysuckle, 16 parts of mango leaves, 12 parts of dandelions, 11 parts of platycodon, 10 parts of stemonae, 12 parts of tangerine peel and 10 parts of liquorice.

3. A method for preparing silver flower mango granules, characterized in that: The following steps are involved: S1: Take 10-30 parts of honeysuckle and 10-20 parts of mango leaves by weight, wash and remove impurities, dry at 80-90°C, crush, add deionized water at a solid-liquid ratio of 1:10-15, reflux and extract at 100-110°C for 3-5 times, each extraction for 1-3h, combine the extracts, filter the residue, centrifuge at 3000-4000r / min for 15-25min, and take the supernatant to obtain a mixed extract A; S2: Taking 5-15 parts of dandelion, 5-15 parts of platycodon and 5-15 parts of stemona by weight, freeze-drying them at a pressure of 0.05-0.08 mbar and a temperature of -10°C--15°C for 35-55 min, cooling them to -30°C--40°C at a rate of 3-6°C / min, drying them for 1-3 h, and crushing them; adding n-butyl ether at a solid-liquid ratio of 1:15-25, extracting them at a temperature of 120-140°C for 2-4 h, centrifuging the extracted liquid at 2000-3000 r / min for 10-20 min, and filtering the supernatant to obtain a mixed extract B; S3: taking 5-15 parts of dried tangerine peel and 5-15 parts of liquorice by weight, drying and crushing, adding ethanol at a solid-liquid ratio of 1:20-30, reflux extraction at a temperature of 80-100°C for 2-4 times, each extraction for 2-4 hours, combining the extracts, and drying in a constant temperature drying oven for 4-6 hours to obtain powder; extracting the above powder with carbon dioxide supercritical fluid, the extraction temperature is 40-60°C, the pressure is 30-50MPa, the flow rate of the supercritical carbon dioxide fluid is set to 280-350L / h, and after 3-5 hours of extraction, a mixed extract C is obtained; S4: In parts by weight, the mixed extract A obtained in step S1, the mixed extract B in step S2, the mixed extract C obtained in step S3 and 30-50 parts of ethanol are stirred at a temperature of 60-70°C and a speed of 500-800r / min for 2-4h; then placed in a constant temperature drying oven and dried at 80-100°C for 4-6h; prepared into granules to obtain the silver flower mango granules.

4. The method for preparing silver flower mango granules according to claim 3, characterized in that: Step S1 is optimized as follows: by weight, 15-25 parts of honeysuckle and 12-16 parts of mango leaves are taken, washed to remove impurities, dried at a temperature of 82-86° C., crushed, added with deionized water at a solid-liquid ratio of 1:12-14, refluxed and extracted at 105-110° C. for 3-4 times, each extraction for 1.5-2.5 hours, the extracts are combined, the residue is filtered, and the supernatant is taken after centrifugation at a speed of 3500-4000 r / min for 18-23 minutes to obtain a mixed extract A.

5. The method for preparing silver flower mango granules according to claim 4, characterized in that: In parts by weight, 22 parts of honeysuckle and 14 parts of mango leaves were washed to remove impurities, dried at 85°C, crushed, and refluxed at 108°C with a solid-liquid ratio of 1:13 for 3 times, each time for 2 hours. The extracts were combined, the residue was filtered, and the supernatant was taken after centrifugation at 3800 r / min for 20 minutes to obtain a mixed extract A.

6. The method for preparing silver flower mango granules according to claim 3, characterized in that: Step S2 is optimized as follows: by weight, 7-12 parts of dandelion, 10-14 parts of platycodon and 6-11 parts of stemona are freeze-dried at a pressure of 0.06-0.07 mbar and a temperature of minus 12°C to minus 14°C for 40-50 min, cooled to minus 32°C to minus 36°C at a rate of 4-6°C / min, dried for 1.5-2.5 h, and crushed; n-butyl ether is added thereto at a solid-liquid ratio of 1:18-22, extracted at a temperature of 130-140°C for 2.5-3.5 h, the extracted liquid is centrifuged at 2200-2600 r / min for 15-18 min, and the supernatant is filtered to obtain a mixed extract B.

7. The method for preparing silver flower mango granules according to claim 6, characterized in that: In parts by weight, 12 parts of dandelion, 11 parts of platycodon and 10 parts of stemona were freeze-dried at a pressure of 0.065 mbar and a temperature of -13°C for 50 min, cooled to -35°C at a rate of 5°C / min, dried for 2 h, and crushed; n-butyl ether was added thereto at a solid-liquid ratio of 1:22, extracted at a temperature of 135°C for 2.5 h, the extracted liquid was centrifuged at 2500 r / min for 16 min, and the supernatant was filtered to obtain a mixed extract B.

8. The method for preparing silver flower mango granules according to claim 3, characterized in that: Step S3 is optimized as follows: taking 8-12 parts of dried tangerine peel and 9-14 parts of licorice by weight, drying and then crushing, adding ethanol according to a solid-liquid ratio of 1:22-26, reflux extraction at a temperature of 85-95° C. for 2-3 times, each extraction for 2-3 hours, combining the extracts, putting them in a constant temperature drying oven for drying for 4-5 hours, and obtaining powder; using carbon dioxide supercritical fluid for extraction, the extraction temperature is 45-55° C., the pressure is 40-50 MPa, the flow rate is 300-330 L / h, and after 4-5 hours of extraction, a mixed extract C is obtained.

9. The method for preparing silver flower mango granules according to claim 8, characterized in that: In parts by weight, 10 parts of dried tangerine peel and 12 parts of licorice are taken, dried and crushed, ethanol is added at a solid-liquid ratio of 1:24, reflux extraction is performed at a temperature of 90°C for 3 times, each extraction is for 2 hours, the extracts are combined, and the extracts are placed in a constant temperature drying oven for drying for 4.5 hours to obtain powder; carbon dioxide supercritical fluid is used for extraction, the extraction temperature is 52°C, the pressure is 46MPa, the flow rate is 320L / h, and after 4.5 hours of extraction, a mixed extract C is obtained.

10. The method for preparing silver flower mango granules according to claim 3, characterized in that: Step S4 is optimized as follows: in parts by weight, the mixed extract A obtained in step S1, the mixed extract B in step S2, the mixed extract C obtained in step S3 and 45 parts of ethanol are stirred at a temperature of 63°C and a rate of 750 r / min for 3.5 hours; then placed in a constant temperature drying oven and dried at 95°C for 4.5 hours; prepared into granules, and the silver flower mango granules can be obtained.

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