Traditional Chinese medicine composition for treating chronic gastritis with anxiety and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating chronic gastritis with anxiety and a preparation method thereof. The invention provides a traditional Chinese medicine composition for treating chronic gastritis with anxiety. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 5-15 parts of dendrobe, 5-15 parts of cortex albiziae, 3-10 parts of rhizoma cyperi, 2-6 parts of radix bupleuri, 5-10 parts of salvia miltiorrhiza, 2-6 parts of pericarpium citri reticulatae, 3-15 parts of radix ophiopogonis, 1-5 parts of liquorice and 1-3 parts of coptis chinensis. The traditional Chinese medicine composition can effectively treat chronic gastritis and improve anxiety and other symptoms caused by chronic gastritis, and the treatment effect of the traditional Chinese medicine composition is obviously better than that of products in the prior art.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating chronic gastritis associated with anxiety and a preparation method thereof. Background Art

[0002] With the development of science and society, psychosomatic diseases closely related to social psychological factors such as work stress, social competition, and environmental pollution have increased rapidly. The previous biomedical model can no longer explain some modern diseases. Many organic or functional diseases may be accompanied by psychological disorders. Psychological disorders have become an important issue facing people in the new century. Clinically, psychosomatic diseases of the digestive system are mostly manifested as organic diseases accompanied by psychological disorders of varying severity. Among them, physical diseases accompanied by anxiety states are particularly common. When diagnosing and treating digestive system diseases, some clinical physicians ignore the existence of psychosomatic diseases, resulting in missed diagnoses and misdiagnoses. Patients undergo repeated examinations and are not cured for a long time, which not only wastes medical expenses and has little effect, but also causes patients to suffer and suffer.

[0003] Gastritis is an inflammation of the gastric mucosa caused by various reasons. It is one of the most common digestive system diseases. Chronic gastritis can be divided into three categories according to its pathological changes: non-atrophic, atrophic and special types of gastritis. Chronic gastritis is a chronic digestive tract disease. Its clinical manifestations are asymptomatic or varying degrees of indigestion symptoms such as upper abdominal pain, lack of appetite, fullness after meals, acid reflux, nausea and belching. Patients with severe atrophic gastritis have anemia, weight loss, glossitis, diarrhea, etc. Chinese medicine believes that chronic gastritis is mostly caused by long-term emotional frustration, improper diet, and irregular work and rest, which leads to liver qi stagnation, spleen dysfunction, stomach disharmony, and long-term deficiency of qi, thus causing various symptoms. It is a common and difficult-to-treat disease of the digestive system. The progression of mucosal atrophy is related to viral infection, age, smoking, drinking and other factors. It is listed as a precancerous state of gastric cancer and is also an important link in the occurrence and development of gastric cancer. Chronic atrophic gastritis is a chronic recurrent disease. Patients have repeated digestive tract discomfort symptoms and have to seek medical treatment repeatedly. High medical expenses and fear of cancer are also factors that cause anxiety. In addition, the rapid development of spiritual and material civilization in modern society has put people in a fast-paced, competitive, and frequent social environment. The body and mind are under tremendous pressure. Continuous tension and maladaptation to the environment have led to a rapid increase in the incidence of psychosomatic diseases. Chronic atrophic gastritis with anxiety is located in the stomach, but it is closely related to the liver. Treatment is to soothe the liver and regulate qi, strengthen the spleen and nourish the stomach. There is currently no Chinese patent medicine for treatment, and it is necessary to develop and research drugs for the effective treatment of chronic gastritis with anxiety.

[0004] Therefore, how to provide a Chinese medicine composition that can effectively treat chronic gastritis and improve patients' anxiety is a technical problem that technical personnel in this field urgently need to solve. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition for treating chronic gastritis associated with anxiety and a preparation method thereof.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The present invention provides a traditional Chinese medicine composition for treating chronic gastritis with anxiety, which is prepared from the following components in parts by weight: 5-15 parts of dendrobium, 5-15 parts of julibrissin bark, 3-10 parts of cyperus rotundus, 2-6 parts of bupleurum, 5-10 parts of salvia miltiorrhiza, 2-6 parts of tangerine peel, 3-15 parts of ophiopogon, 1-5 parts of liquorice and 1-3 parts of coptis.

[0008] Preferably, it is prepared from the following components in parts by weight: 7-13 parts of Dendrobium; 7-13 parts of Albizzia Julibrissin; 5-8 parts of Cyperus rotundus; 3-5 parts of Bupleurum; 6-9 parts of Salvia miltiorrhiza; 3-5 parts of Citrus reticulata; 5-13 parts of Ophiopogon japonicus; 2-4 parts of Licorice; and 2 parts of Coptis chinensis.

[0009] The present invention also provides a method for preparing the Chinese medicine composition for treating chronic gastritis associated with anxiety, comprising the following steps:

[0010] (1) mixing and grinding dendrobium, julibrissin bark, cyperus rotundus, bupleurum, salvia miltiorrhiza, dried orange peel, ophiopogon japonicus, liquorice and coptis chinensis to obtain material 1;

[0011] (2) mixing the material 1 with water for extraction, and filtering to obtain a filtrate and a filter residue;

[0012] (3) mixing the filter residue with water and boiling, and filtering to obtain a decoction;

[0013] (4) The filtrate is mixed with the decoction, and concentrated to obtain a Chinese medicine composition for treating chronic gastritis with anxiety.

[0014] Preferably, the ground material in step (1) is passed through a 40-60 mesh sieve, and the material under the sieve is collected as material 1.

[0015] Preferably, the mass ratio of the material 1 to water in step (2) is 1:4-6.

[0016] Preferably, the extraction time in step (2) is 2 to 3 hours.

[0017] Preferably, the water temperature during the extraction in step (2) is maintained at 45-65°C.

[0018] Preferably, the mass ratio of the filter residue to water in step (3) is 1:3-5.

[0019] Preferably, the decocting time in step (3) is 100 to 160 minutes.

[0020] Preferably, step (4) is concentrated to 1 / 6 to 1 / 4 of the original volume.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] The composition provided by the present invention has the main effects of soothing the liver and relieving depression, nourishing the stomach and clearing away heat. The main drug in the prescription, Dendrobium officinale, is sweet in taste, slightly cold, nourishes yin and benefits the stomach. Because the stomach is dry soil, it likes moisture and hates dryness, and the product that nourishes the stomach yin can restore the physiological characteristics of the stomach that likes moisture and descending; the assistant drug, Albizzia julibrissin, relieves depression and calms the mind, promotes blood circulation and reduces swelling; Cyperus rotundus and Bupleurum chinense soothe the liver and relieve depression, regulate qi and relieve fullness; the adjuvant, Tangerine peel, regulates qi and strengthens the spleen, and eliminates dampness and resolves phlegm; Salvia miltiorrhiza promotes blood circulation and relieves pain, clears the heart and eliminates restlessness; Coptis chinensis clears heat and resolves dampness, clears the heart and purges fire; Ophiopogon japonicus benefits the stomach and nourishes yin, clears the heart and eliminates restlessness; the guiding drug, Licorice, invigorates qi and replenishes the middle, and harmonizes the drugs. The whole prescription has the effects of nourishing yin and nourishing the stomach, soothing the liver and regulating qi, clearing the heart and calming the mind, and treats the symptoms of chronic gastritis of insufficient stomach yin and liver qi stagnation accompanied by anxiety.

[0023] The Chinese medicine composition provided by the present invention can effectively treat chronic gastritis and improve symptoms such as anxiety caused by chronic gastritis, and its therapeutic effect is significantly better than that of existing products. DETAILED DESCRIPTION

[0024] The present invention provides a traditional Chinese medicine composition for treating chronic gastritis with anxiety, which is prepared from the following components in parts by weight: 5-15 parts of dendrobium, 5-15 parts of julibrissin bark, 3-10 parts of cyperus rotundus, 2-6 parts of bupleurum, 5-10 parts of salvia miltiorrhiza, 2-6 parts of tangerine peel, 3-15 parts of ophiopogon, 1-5 parts of liquorice and 1-3 parts of coptis.

[0025] Preferably, it is prepared from the following components by weight: 7-13 parts of Dendrobium; 7-13 parts of Albizzia julibrissin; 5-8 parts of Cyperus rotundus; 3-5 parts of Bupleurum chinense; 6-9 parts of Salvia miltiorrhiza; 3-5 parts of Tangerine peel; 5-13 parts of Ophiopogon japonicus; 2-4 parts of Licorice; 2 parts of Coptis chinensis;

[0026] It is further preferably prepared from the following components in parts by weight: 9-11 parts of Dendrobium; 9-11 parts of Albizzia julibrissin; 6-7 parts of Cyperus rotundus; 4 parts of Bupleurum; 7-8 parts of Salvia miltiorrhiza; 4 parts of Citrus reticulata; 7-11 parts of Ophiopogon japonicus; 3 parts of Licorice; and 2 parts of Coptis chinensis.

[0027] More preferably, it is prepared from the following components in parts by weight: 10 parts of Dendrobium; 10 parts of Albizzia Julibrissin; 7 parts of Cyperus rotundus; 4 parts of Bupleurum chinense; 8 parts of Salvia miltiorrhiza; 4 parts of Citrus reticulatae; 9 parts of Ophiopogon japonicus; 3 parts of Licorice; and 2 parts of Coptis chinensis.

[0028] The present invention also provides a method for preparing the Chinese medicine composition for treating chronic gastritis associated with anxiety, comprising the following steps:

[0029] (1) mixing and grinding dendrobium, julibrissin bark, cyperus rotundus, bupleurum, salvia miltiorrhiza, dried orange peel, ophiopogon japonicus, liquorice and coptis chinensis to obtain material 1;

[0030] (2) mixing the material 1 with water for extraction, and filtering to obtain a filtrate and a filter residue;

[0031] (3) mixing the filter residue with water and boiling, and filtering to obtain a decoction;

[0032] (4) The filtrate is mixed with the decoction, and concentrated to obtain a Chinese medicine composition for treating chronic gastritis with anxiety.

[0033] In the present invention, the ground material in step (1) is passed through a 40-60 mesh sieve, and the material under the sieve is collected as material 1; preferably 44-56 mesh; more preferably 48-52 mesh; and more preferably 50 mesh.

[0034] In the present invention, the mass ratio of the material 1 to water in step (2) is 1:4-6, preferably 1:5.

[0035] In the present invention, the extraction time in step (2) is 2 to 3 hours, preferably 3 hours.

[0036] In the present invention, the water temperature during the extraction in step (2) is maintained at 45-65°C; preferably 47-63°C; more preferably 49-61°C; and more preferably 55°C.

[0037] In the present invention, the mass ratio of the filter residue to water in step (3) is 1:3-5, preferably 1:4.

[0038] In the present invention, the decoction time in step (3) is 100 to 160 min; preferably 110 to 150 min; more preferably 120 to 140 min; and more preferably 130 min.

[0039] In the present invention, step (4) is concentrated to 1 / 6 to 1 / 4 of the original volume; preferably 1 / 5.

[0040] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0041] Example 1

[0042] A traditional Chinese medicine composition for treating chronic gastritis with anxiety is prepared from the following components in parts by mass: 5 parts of dendrobium, 5 parts of julibrissin bark, 3 parts of cyperus rotundus, 2 parts of bupleurum, 5 parts of salvia miltiorrhiza, 2 parts of tangerine peel, 3 parts of ophiopogon, 1 part of liquorice and 1 part of coptis chinensis.

[0043] The preparation method of the Chinese medicine composition for treating chronic gastritis associated with anxiety comprises the following steps:

[0044] (1) Mix and grind dendrobium, julibrissin bark, cyperus rotundus, bupleurum, salvia miltiorrhiza, dried orange peel, ophiopogon japonicus, liquorice and coptis chinensis, and pass the ground material through a 40-mesh sieve, and collect the material under the sieve as material 1;

[0045] (2) mixing the material 1 with water in a mass ratio of 1:4 and leaching for 2 hours, filtering to obtain a filtrate and a filter residue; the water temperature during leaching is maintained at 45° C.;

[0046] (3) mixing the filter residue with water in a mass ratio of 1:3 and boiling for 100 min, and filtering to obtain a decoction;

[0047] (4) The filtrate is mixed with the decoction and concentrated to 1 / 6 of the original volume to obtain a Chinese medicine composition for treating chronic gastritis with anxiety.

[0048] Example 2

[0049] A traditional Chinese medicine composition for treating chronic gastritis with anxiety is prepared from the following components in parts by mass: 15 parts of dendrobium, 15 parts of julibrissin bark, 10 parts of cyperus rotundus, 6 parts of bupleurum, 10 parts of salvia miltiorrhiza, 6 parts of tangerine peel, 15 parts of ophiopogon, 5 parts of liquorice and 3 parts of coptis.

[0050] The preparation method of the Chinese medicine composition for treating chronic gastritis associated with anxiety comprises the following steps:

[0051] (1) Mix and grind dendrobium, julibrissin bark, cyperus rotundus, bupleurum, salvia miltiorrhiza, dried orange peel, ophiopogon japonicus, liquorice and coptis chinensis, and pass the ground material through a 60-mesh sieve, and collect the material under the sieve as material 1;

[0052] (2) mixing the material 1 with water at a mass ratio of 1:6 and leaching for 3 hours, filtering to obtain a filtrate and a filter residue; the water temperature during leaching is maintained at 65° C.;

[0053] (3) mixing the filter residue with water in a mass ratio of 1:5 and boiling for 160 min, and filtering to obtain a decoction;

[0054] (4) The filtrate is mixed with the decoction and concentrated to 1 / 4 of the original volume to obtain a Chinese medicine composition for treating chronic gastritis with anxiety.

[0055] Example 3

[0056] A traditional Chinese medicine composition for treating chronic gastritis with anxiety is prepared from the following components in parts by mass: 10 parts of dendrobium; 10 parts of julibrissin bark; 7 parts of cyperus rotundus; 4 parts of bupleurum; 8 parts of salvia miltiorrhiza; 4 parts of tangerine peel; 9 parts of ophiopogon; 3 parts of liquorice; and 2 parts of coptis chinensis.

[0057] The preparation method of the Chinese medicine composition for treating chronic gastritis associated with anxiety comprises the following steps:

[0058] (1) Mix and grind dendrobium, julibrissin bark, cyperus rotundus, bupleurum, salvia miltiorrhiza, dried orange peel, ophiopogon japonicus, liquorice and coptis chinensis, and pass the ground material through a 50-mesh sieve, and collect the material under the sieve as material 1;

[0059] (2) mixing the material 1 with water at a mass ratio of 1:5 and leaching for 3 hours, filtering to obtain a filtrate and a filter residue; the water temperature during leaching is maintained at 55° C.;

[0060] (3) mixing the filter residue with water in a mass ratio of 1:4 and boiling for 130 min, and filtering to obtain a decoction;

[0061] (4) The filtrate is mixed with the decoction and concentrated to 1 / 5 of the original volume to obtain a Chinese medicine composition for treating chronic gastritis with anxiety.

[0062] Experimental Example 1

[0063] 60 patients with chronic gastritis accompanied by anxiety symptoms admitted to the Affiliated Hospital of Shaanxi University of Chinese Medicine were selected. The age range was 29 to 69 years old, with an average age of 47.5 years. The course of disease was 1 to 11 years, with an average course of disease of 8.5 years. They were divided into three groups, with half male and half female in each group. There was no statistically significant difference in the independence data and mean data of the clinical data of the three groups of patients (P>0.05).

[0064] The diagnostic criteria for patients are:

[0065] Refer to the "Guidelines for Clinical Research of New Chinese Medicines" for the differentiation criteria of spleen deficiency and blood stasis type and refer to the "China (2017, Shanghai) Consensus on Chronic Gastritis" which may or may not have symptoms related to dyspepsia.

[0066] Depressive symptoms were assessed using the Hamilton Anxiety and Depression Rating Scale, and patients with chronic gastritis with a score of ≥14 were included in this trial.

[0067] Inclusion criteria: those who meet the above criteria; agree to clinical observation; age ≥ 20 years old; Exclusion criteria: those with concurrent tumor cancer; those with concurrent serious diseases of other systems; those with complications that may affect the efficacy observation or contraindications to the trial drugs; women who are preparing for pregnancy or pregnant, or women who are breastfeeding; those who must continue to use drugs that may affect the efficacy of this experiment (such as proton pump inhibitors, gastrointestinal motility drugs, etc.); those with a history of gastric surgery; those who are allergic to the trial drugs or have allergic constitutions.

[0068] Treatment effect evaluation criteria:

[0069] The patient's gastric mucosa was completely restored after gastroscopy, all laboratory test indicators returned to normal, and the patient's stomach bloating and stomach pain completely disappeared, which was considered markedly effective; the patient's clinical stomach pain, stomach bloating and other symptoms were significantly alleviated after gastroscopy and laboratory test results improved, which was considered effective; the patient who did not meet the requirements of marked effectiveness and effectiveness was considered ineffective, where effective rate = (marked effectiveness + effectiveness) / total number of cases × 100%.

[0070] Anxiety and depression scores: The Hamilton Anxiety and Depression Scale was used to evaluate the score changes of the two groups of patients before and after treatment through conversation and observation, and the total scores of the two were recorded by the physician.

[0071] The degree of anxiety and depression was calculated according to the score reduction rate = (total score before treatment - total score after treatment) / total score before treatment × 100%; a reduction rate ≥ 75% or a total score < 7 points was considered cured; a reduction rate ≥ 50% was considered markedly effective; a reduction rate ≥ 25% was considered effective; and a reduction rate < 25% was considered ineffective.

[0072] The drug prepared by the method of Example 3 was used as the experimental group, and the dosage was: 9 g each time, twice a day, 7 days as a course of treatment, and 8 courses of treatment were given.

[0073] Control group 1, other methods are the same as Example 3, the only difference is that Dendrobium and Albizzia julibrissin are replaced with equal amounts of Glehnia littoralis and Poria cocos, and other medications and dosages remain unchanged; the method of administration is: 9 g each time, twice a day, 7 days as a course of treatment, and 8 courses of treatment.

[0074] The prior art group was given Wei Fuchun capsules (composition: red ginseng, stir-fried fructus aurantii, fragrant tea leaves, Hangzhou Hu Qing Yu Tang Pharmaceutical Co., Ltd., approval number: National Medicine Standard Z20090697), taken twice a day, 4 capsules each time, 7 days as a course of treatment, and 8 courses of treatment.

[0075] After the treatment was completed, the recovery of chronic gastritis and anxiety in each group of patients was investigated. The results are shown in Tables 1 and 2.

[0076] Table 1 Questionnaire for recovery from chronic gastritis

[0077] Group Significant effect efficient invalid Total Effectiveness Experimental Group 6 12 2 90％ Control group 1 4 9 7 70％ Existing Technology Group 5 6 9 55％

[0078] Table 2 Anxiety recovery questionnaire

[0079] Group Significant effect efficient invalid Total Effectiveness Experimental Group 12 7 1 95％ Control group 1 8 9 3 85％ Existing Technology Group 6 7 7 70％

[0080] It can be seen from the contents recorded in Table 1 and Table 2 that the present invention has a good therapeutic effect on chronic gastritis. Similarly, it also has a significant improvement effect on symptoms such as anxiety associated with chronic gastritis. Its therapeutic effect is significantly better than the drugs in the prior art.

[0081] It can be seen from the relevant data of control group 1 that even if the components are replaced with Chinese medicinal ingredients with similar efficacy, the efficacy of the composition will be significantly affected. Therefore, only the complete Chinese medicinal formula of the present invention can achieve the best therapeutic effect.

[0082] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating chronic gastritis associated with anxiety, characterized in that: The invention is prepared from the following components in parts by weight: 5-15 parts of dendrobium, 5-15 parts of julibrissin bark, 3-10 parts of cyperus, 2-6 parts of bupleurum, 5-10 parts of salvia miltiorrhiza, 2-6 parts of tangerine peel, 3-15 parts of ophiopogon, 1-5 parts of liquorice and 1-3 parts of coptis.

2. A Chinese medicine composition for treating chronic gastritis with anxiety according to claim 1, characterized in that: The invention is prepared from the following components in parts by weight: 7-13 parts of dendrobium; 7-13 parts of julibrissin bark; 5-8 parts of cyperus rotundus; 3-5 parts of bupleurum; 6-9 parts of salvia miltiorrhiza; 3-5 parts of tangerine peel; 5-13 parts of ophiopogon; 2-4 parts of liquorice; and 2 parts of coptis chinensis.

3. The method for preparing the Chinese medicine composition for treating chronic gastritis with anxiety according to claim 1 or 2, characterized in that: The steps include: (1) mixing and grinding dendrobium, julibrissin bark, cyperus rotundus, bupleurum, salvia miltiorrhiza, dried orange peel, ophiopogon japonicus, liquorice and coptis chinensis to obtain material 1; (2) mixing the material 1 with water for extraction, and filtering to obtain a filtrate and a filter residue; (3) mixing the filter residue with water and boiling, and filtering to obtain a decoction; (4) The filtrate is mixed with the decoction, and concentrated to obtain a Chinese medicine composition for treating chronic gastritis with anxiety.

4. The preparation method according to claim 3, characterized in that: The ground material in step (1) is passed through a 40-60 mesh sieve, and the material under the sieve is collected as material 1.

5. The preparation method according to claim 3, characterized in that: In step (2), the mass ratio of material 1 to water is 1:4-6.

6. The preparation method according to claim 3, characterized in that: The extraction time in step (2) is 2 to 3 hours.

7. The preparation method according to claim 3 or 6, characterized in that: The water temperature during the extraction in step (2) is maintained at 45-65°C.

8. The preparation method according to claim 3, characterized in that: The mass ratio of the filter residue to water in step (3) is 1:3-5.

9. The preparation method according to claim 3 or 8, characterized in that: The decocting time in step (3) is 100 to 160 minutes.

10. The preparation method according to claim 3, characterized in that: The step (4) is concentrated to 1 / 6 to 1 / 4 of the original volume.