Preparation method and application of food composition

Abstract

The invention provides a traditional Chinese medicine composition for protecting gastric mucosa as well as a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 1-40 parts of oat, 1-30 parts of millet, 1-30 parts of Chinese yam, 1-20 parts of white hyacinth bean, 0.1-5 parts of hericium erinaceus, 0.1-5 parts of dendrobium officinale, 0.1-5 parts of poria cocos and 0.1-5 parts of tremella fuciformis. The traditional Chinese medicine composition has the effects of improving hyperemia, edema and erosion of gastric mucosa, remarkably reducing the levels of MDA and TNF-alpha and increasing the enzyme activity of SOD.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a preparation method and application of a food composition. Background Art

[0002] In today's society, the fast-paced work and life make many people eat irregularly, which also gives rise to many health problems. The number of patients with gastrointestinal diseases in the world increased from 150 million in 1985 to 500 million in 2011, and is expected to reach 700 million by 2025. There are about 120 million patients with gastrointestinal diseases in my country, which is a "gastric disease power" in the world. Gastric diseases have seriously threatened the health of the people. The digestive function of the stomach is mainly completed by mechanical and chemical effects. The gastric mucosa, as the part of the stomach that contacts the most food, is prone to problems. Under normal circumstances, mucus secreted by the gastric mucosa and mucosal protective factors such as the surface epithelium of the gastric mucosa can protect the gastric mucosa from mechanical friction, thermal stimulation, gastric acid, pepsin, bacteria and other mucosal attack factors, thereby preventing gastric mucosal damage. However, due to the fast pace of work, mental stress, heavy drinking, smoking, long-term drinking of strong tea, irregular diet and other factors of modern people, the mucosal attack factors are strengthened and the mucosal protective factors are weakened, causing gastric mucosal damage, and even gradually developing into chronic gastritis, gastric ulcer and other gastric diseases. The occurrence and development of gastric disease are related to gastric mucosal damage to a certain extent.

[0003] According to traditional Chinese medicine, the spleen and stomach play a vital role in the life activities of the human body. The spleen is the foundation of the acquired constitution, responsible for blood and muscles, and responsible for the transportation and distribution of the essence of water and grain in the body. It is the source of qi and blood. The spleen and stomach are the origin of the life activities of the human body, and the nourishment of the human body depends on the normal function of the spleen and stomach. If the spleen functions normally, it can transport the essence of water and grain in the diet and transfer it to the whole body to meet the normal physiological needs of the human body, so that people are full of energy and energy. If the spleen's blood control function is normal, the blood will flow in the veins without overflowing, so that the body has sufficient qi and blood. If the spleen fails to function properly, the appetite will be poor, the appetite will be poor, and there will be abdominal pain and bloating. If the essence of water and grain is difficult to absorb, the body will be malnourished, and the face will be pale and the muscles and bones will be thin, and the muscles and bones will not be full.

[0004] Many people choose to take medication to regulate spleen and stomach problems. The drugs used clinically to treat gastric mucosal damage mainly include gastric acid neutralizers, H2 receptor antagonists, H+ pump inhibitors, etc. However, taking these drugs may have problems such as long treatment time, slow healing, high recurrence rate, and large side effects. Summary of the invention

[0005] In view of this, the object of the present invention is to provide a Chinese medicine composition formula having the effect of protecting gastric mucosa and a preparation method thereof.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] The present invention first provides a Chinese medicine composition, which comprises the following raw materials in weight ratio: 1-40 parts of oats, 1-30 parts of millet, 1-30 parts of yam, 1-20 parts of white hyacinth bean, 0.1-5 parts of Hericium erinaceus, 0.1-5 parts of Dendrobium officinale, 0.1-5 parts of Poria cocos, and 0.1-5 parts of Tremella fuciformis. The composition of the present invention can be directly ground into powder, or it can be an extract prepared by conventional means in the art. The Chinese medicine used in the composition of the present invention can also be used in the form of directly ground into powder, extract, or other processed forms.

[0008] Preferably, the Chinese medicine composition comprises: 15-30 parts of oats, 10-20 parts of millet, 3-12 parts of yam, 2-10 parts of white hyacinth bean, 0.5-4 parts of Hericium erinaceus, 0.5-4 parts of Dendrobium officinale, 0.5-4 parts of Poria cocos, and 0.5-4 parts of Tremella fuciformis.

[0009] Preferably, the Chinese medicine composition comprises: 20-25 parts of oats, 12-15 parts of millet, 5-9 parts of yam, 2-6 parts of white hyacinth bean, 0.5-3 parts of Hericium erinaceus, 0.5-3 parts of Dendrobium officinale, 0.5-3 parts of Poria cocos, and 0.5-3 parts of Tremella fuciformis.

[0010] Preferably, the Chinese medicine composition comprises: 20-22 parts of oats, 12-14 parts of millet, 5-6 parts of yam, 2-4 parts of white hyacinth bean, 0.5-1 part of Hericium erinaceus, 0.5-1 part of Dendrobium officinale, 0.5-1 part of Poria cocos, and 0.5-1 part of Tremella fuciformis.

[0011] More preferably, the Chinese medicine composition of the present invention comprises the following components in parts by weight: 22 parts of oats, 14 parts of millet, 6 parts of yam, 4 parts of white dung bean, 1 part of hericium erinaceus, 1 part of dendrobium officinale, 1 part of tuckahoe, and 1 part of tremella; or 20 parts of oats, 12 parts of millet, 5 parts of yam, 2 parts of white dung bean, 0.5 part of hericium erinaceus, 0.5 part of dendrobium officinale, 0.5 part of tuckahoe, and 3 parts of tremella

[0012] The present invention further provides a medicine, health product or food containing any of the above-mentioned traditional Chinese medicine compositions.

[0013] Specifically, the drug is in any pharmaceutically acceptable dosage form.

[0014] In a further embodiment, the pharmaceutically acceptable dosage form is granules, oral solution, tablets, capsules or pills.

[0015] The present invention also proposes the use of any of the above-mentioned Chinese medicine compositions in the preparation of medicines for gastric mucosal injury or gastritis. The use may be any method that is beneficial to improving the corresponding symptoms of the patient, including treatment or prevention.

[0016] Furthermore, the gastric mucosal damage may be gastric mucosal damage caused by alcohol.

[0017] The present invention proposes the use of any of the above-mentioned traditional Chinese medicine compositions in the preparation of medicines, health products or foods for protecting gastric mucosa.

[0018] The present invention further provides a method for preparing the Chinese medicine composition as described in any one of the above, comprising the following steps:

[0019] (1) Take the medicinal material and add 8-12 times water to reflux and extract twice, each time for 1 hour, combine the extracts and filter;

[0020] (2) concentrating the extract to a relative density of 1.10 to 1.15 at 55 to 60° C. to obtain a concentrated solution;

[0021] (3) centrifugally filtering the concentrated solution to obtain a centrifuged concentrated solution;

[0022] (4) The concentrated solution obtained in step (3) is spray-dried at an inlet temperature of 170-180° C. and an outlet temperature of not less than 75° C. to obtain a dry extract;

[0023] (5) The dry extract obtained in step (4) is crushed and sieved as needed to obtain the Chinese medicine composition.

[0024] The preparation method of the Chinese medicine composition comprises the following steps:

[0025] (1) Take the medicinal material and add 10 times water to reflux and extract twice, each time for 1 hour, combine the extracts and filter;

[0026] (2) concentrating the extract to a relative density of 1.10 to 1.15 at 55 to 60° C. to obtain a concentrated solution;

[0027] (3) centrifugally filtering the concentrated solution to obtain a centrifuged concentrated solution;

[0028] (4) The concentrated solution obtained in step (3) is spray-dried at an inlet temperature of 175° C. and an outlet temperature of not less than 75° C. to obtain a dry extract;

[0029] (5) The dry extract obtained in step (4) is crushed and sieved as needed to obtain the Chinese medicine composition.

[0030] In the Chinese medicine composition provided by the present invention, millet tastes sweet and salty, can invigorate the stomach and remove dampness, soothe the stomach and promote sleep, and is compatible with oats, which can warm the spleen and stomach, and nourish the heart and calm the mind; yam can invigorate the lungs and invigorate the spleen, consolidate the kidneys and benefit the essence, can invigorate the spleen qi, and nourish the kidney yin essence, can treat all kinds of deficiency and damage, treat the five labors and seven injuries, eliminate irritability and heat, and invigorate the heart qi deficiency, and can be compatible with Poria cocos, so that the spleen can be healthy and the qi can be generated, which can effectively help the source of acquired biochemistry; white hyacinth bean can harmonize the middle and eliminate dampness, invigorate the spleen and stop diarrhea, and can help invigorate the spleen and eliminate dampness; Hericium erinaceus is sweet and flat in nature and flavor, invigorates the stomach and replenishes deficiency, and is sweet and salty in nature and flavor, and benefits the stomach and produces body fluid, which can replenish water on the one hand and promote water transportation on the other hand, which complement each other; Tremella is flat in nature, sweet and light in taste, moisturizes the lungs and nourishes the stomach, and nourishes and produces body fluid. Each component is safe and reliable, has no toxic side effects, and has no drug dependence, and is safe and effective for long-term consumption. All medicines are used together to play the effects of invigorating the spleen and stomach and protecting the gastric mucosa.

[0031] Experiments have shown that the composition of the present invention can significantly reduce the symptoms of gastric mucosal congestion, edema and bleeding in model rats, and can also significantly reduce the levels of MDA and TNF-α and increase the activity of SOD enzyme, indicating that it has a significant protective effect on gastric mucosal damage and gastritis caused by alcohol in rats. DETAILED DESCRIPTION

[0032] As mentioned above, the present invention aims to provide a Chinese medicine composition and its preparation method and application. The following will be described in detail in conjunction with the contents of the experimental examples.

[0033] The present invention provides a Chinese medicine composition for treating insufficient stomach yin, spleen deficiency and poor appetite, and spleen and stomach deficiency and coldness, wherein the Chinese medicine composition has the effects of strengthening the spleen and stomach, protecting the gastric mucosa, etc. Specifically, the Chinese medicine composition provided in the present invention includes the following raw materials: oats, millet, yam, white hyacinth bean, Hericium erinaceus, Dendrobium officinale, Poria cocos, and Tremella fuciformis. Among them, oats (Avenasativa L.) are annual herbaceous plants of the Poaceae family and the genus Avena. The seeds of naked oats are not shelled, called naked oats (Avena sativa ssp.nuda), which is the main cultivated variety in my country; millet (millet) is a herbaceous plant of the genus Setaria of the Poaceae family, and the grains of millet are edible, which is one of the important food crops in northern China; the grains are called "millet" after peeling; yam is the dried rhizome of the Dioscorea plant. White hyacinth bean is the dried mature seed of the leguminous plant Dolichos lablab L. Hericium erinaceus (Bull.) Pers. is a fungus of the family Odontaceae and the genus Hericium. Dendrobium officinale is the dried stem of the orchid Dendrobium officinale Kimura et Migo. Poria cocos is the dried sclerotium of the Polyporaceae fungus Poria cocos (Schw.) Wolf. Tremella fuciformis is a fruiting body of a fungus belonging to the phylum Basidiomycetes, class Tremellales, family Tremellaceae, and genus Tremella. If the specific conditions are not specified in the present invention, they shall be carried out according to conventional conditions or conditions recommended by the manufacturer. The raw materials or excipients used, as well as the reagents or instruments used without indicating the manufacturer, are all conventional products that can be obtained commercially.

[0034] The first aspect of the present invention discloses a Chinese medicine composition, which comprises the following raw materials in weight ratio: 1-40 parts of oats, 1-30 parts of millet, 1-30 parts of yam, 1-20 parts of white dung bean, 0.1-5 parts of Hericium erinaceus, 0.1-5 parts of Dendrobium officinale, 0.1-5 parts of Poria cocos, and 0.1-5 parts of Tremella fuciformis. Preferably, the Chinese medicine composition comprises: 15-30 parts of oats, 10-20 parts of millet, 3-12 parts of yam, 2-10 parts of white dung bean, 0.5-4 parts of Hericium erinaceus, 0.5-4 parts of Dendrobium officinale, 0.5-4 parts of Poria cocos, and 0.5-4 parts of Tremella fuciformis.

[0035] Preferably, the Chinese medicine composition comprises: 20-25 parts of oats, 12-15 parts of millet, 5-9 parts of yam, 2-6 parts of white hyacinth bean, 0.5-3 parts of Hericium erinaceus, 0.5-3 parts of Dendrobium officinale, 0.5-3 parts of Poria cocos, and 0.5-3 parts of Tremella fuciformis.

[0036] Preferably, the Chinese medicine composition comprises: 20-22 parts of oats, 12-14 parts of millet, 5-6 parts of yam, 2-4 parts of white hyacinth bean, 0.5-1 part of Hericium erinaceus, 0.5-1 part of Dendrobium officinale, 0.5-1 part of Poria cocos, and 0.5-1 part of Tremella fuciformis.

[0037] Specifically, the traditional Chinese medicine composition of the present invention comprises the following components in parts by weight: 22 parts of oats, 14 parts of millet, 6 parts of yam, 4 parts of white hyacinth bean, 1 part of hericium erinaceus, 1 part of dendrobium officinale, 1 part of poria cocos, and 1 part of tremella; or 20 parts of oats, 12 parts of millet, 5 parts of yam, 2 parts of white hyacinth bean, 0.5 part of hericium erinaceus, 0.5 part of dendrobium officinale, 0.5 part of poria cocos, and 3 parts of tremella.

[0038] In a further embodiment, the Chinese medicine composition further comprises a pharmaceutically acceptable excipient, so that the Chinese medicine composition can be in any pharmaceutically acceptable dosage form, such as granules, oral solution, tablets, capsules or pills.

[0039] The second aspect of the present invention provides a method for preparing the Chinese medicine composition described in any one of the first aspects of the present invention, wherein the raw materials are sequentially subjected to water extraction, concentration, centrifugation, spray drying, and granulation, thereby extracting effective components from the pharmaceutical composition to the maximum extent, and the granules, oral solutions, tablets, capsules, or pills still have the same effects. The specific preparation of the Chinese medicine composition comprises the following steps:

[0040] (1) Take the medicinal material and add 8-12 times water to reflux and extract twice, each time for 1 hour, combine the extracts and filter;

[0041] (2) concentrating the extract to a relative density of 1.10 to 1.15 at 55 to 60° C. to obtain a concentrated solution;

[0042] (3) centrifugally filtering the concentrated solution to obtain a centrifuged concentrated solution;

[0043] (4) The concentrated solution obtained in step (3) is spray-dried at an inlet temperature of 170-180° C. and an outlet temperature of not less than 75° C. to obtain a dry extract;

[0044] (5) The dry extract obtained in step (4) is crushed and sieved as needed to obtain the Chinese medicine composition.

[0045] The technical solution of the present invention is described more completely below in conjunction with specific embodiments.

[0046] Example 1 Preparation of Chinese medicine composition

[0047] The traditional Chinese medicine composition comprises the following raw materials: 22 parts of oats, 14 parts of millet, 6 parts of yam, 4 parts of white hyacinth bean, 1 part of hericium erinaceus, 1 part of dendrobium officinale, 1 part of tuckahoe and 1 part of tremella.

[0048] The specific preparation steps are as follows:

[0049] (1) Take the medicinal material and add 10 times water to reflux and extract twice, each time for 1 hour, combine the extracts and filter;

[0050] (2) concentrating the extract to a relative density of 1.10 to 1.15 at 55 to 60° C. to obtain a concentrated solution;

[0051] (3) centrifugally filtering the concentrated solution to obtain a centrifuged concentrated solution;

[0052] (4) spray drying the concentrated solution obtained in step (3) at an inlet temperature of 175° C. and an outlet temperature of not less than 75° C. to obtain a dry extract;

[0053] (5) The dry extract obtained in step (4) is crushed and sieved as needed to obtain the Chinese medicine composition.

[0054] Example 2 Preparation of Chinese medicine composition

[0055] The Chinese medicine composition comprises the following raw materials: 20 parts of oats, 12 parts of millet, 5 parts of yam, 2 parts of white hyacinth bean, 0.5 part of hericium erinaceus, 0.5 part of dendrobium officinale, 0.5 part of tuckahoe and 3 parts of tremella.

[0056] The specific preparation steps are as follows:

[0057] (1) Take the medicinal material and add 10 times water to reflux and extract twice, each time for 1 hour, combine the extracts and filter;

[0058] (2) concentrating the extract to a relative density of 1.10 to 1.15 at 55 to 60° C. to obtain a concentrated solution;

[0059] (3) centrifugally filtering the concentrated solution to obtain a centrifuged concentrated solution;

[0060] (4) spray drying the concentrated solution obtained in step (3) at an inlet temperature of 175° C. and an outlet temperature of not less than 75° C. to obtain a dry extract;

[0061] (5) The dry extract obtained in step (4) is crushed and sieved as needed to obtain the Chinese medicine composition.

[0062] Experimental Example 3 Effect of the present invention on the alcohol-induced acute gastric mucosal injury model

[0063] 1. Experimental Materials

[0064] 1.1 Animals

[0065] SD rats, SPF grade, male, weighing 180-200 g, were purchased from Zhejiang Weitonglihua Experimental Animal Technology Co., Ltd., license number: SCXK (Zhejiang) 2019-0001, certificate number: 20220817Aazz0619000382.

[0066] 1.2 Drugs and reagents

[0067] The Chinese medicine composition (dry extract powder) in Example 1 was prepared by Jiangsu Kangyuan Pharmaceutical Co., Ltd.; Omeprazole was prepared by Shanxi Jinhua Huixing Pharmaceutical Co., Ltd., batch number: H20045975, specification: 20 mg / tablet. Anhydrous ethanol was prepared by Shanghai Shenggong Biotechnology Co., Ltd., batch number: H618WA7002; Sodium chloride injection was prepared by Shijiazhuang Siyao Co., Ltd., specification: 500 mL / bottle, batch number: 2003193205; Chloral hydrate was prepared by Shanghai Shiguo Pharmaceutical Group Chemical Reagent Co., Ltd., specification: 250 g / bottle, batch number: 20180629; Malondialdehyde (MDA) assay kit was prepared by Nanjing Jiancheng Bioengineering Research Institute, batch number: 221105; Superoxide dismutase (SOD) assay kit was prepared by Nanjing Jiancheng Bioengineering Research Institute, batch number: 221207; Tumor necrosis factor (TNF-α) assay kit was prepared by Invitrogen, USA, batch number: 323787-005.

[0068] 1.3 Instruments

[0069] Ultra-low temperature refrigerator (Haier Company, model: DW-86L728); electronic balance (Sartorius Scientific Instruments Company, model: BSA224S-CW); weight scale (Shanghai Xiangchuan Electronic Scale Co., Ltd., model: ACS-SC-DA); electric constant temperature blast drying oven (Shanghai Jinghong Experimental Equipment Co., Ltd., model: DHG-9076A).

[0070] 2. Experimental methods

[0071] 60 male SD rats were randomly divided into 6 groups, namely normal group, model group, omeprazole group (30 mg / kg), low-, medium- and high-dose groups of Chinese medicine composition (4.17 g / kg, 8.33 g / kg, 16.67 g crude drug / kg), with 10 rats in each group. After 5 days of adaptive feeding of rats, the formal experiment began. The omeprazole group and the Chinese medicine composition group were given corresponding drugs by gavage every day, and the normal group and model group were given normal saline for 14 consecutive days. Rats were fasted for 24 hours before the last administration. One hour after the last administration, the normal group was given 1 mL of normal saline, and the model group and each administration group were given 1 mL of anhydrous ethanol for 1 hour, causing acute gastric mucosal injury in rats.

[0072] One hour after rats were gavaged with anhydrous ethanol, they were anesthetized with 10% chloral hydrate intraperitoneally, the abdominal cavity was opened along the midline of the abdomen, the stomach was taken out, the stomach wall was cut open along the greater curvature of the stomach, and the food residues in the stomach were washed out with 0.9% sodium chloride solution. The damage of the gastric mucosa was observed under a stereomicroscope, and the length and width of the bleeding point or bleeding band were measured with a vernier caliper. Because the width represents the severity of the injury much greater than the length, double points are scored. The scoring criteria are shown in Table 1. Part of the stomach tissue of the rats was also retained to detect the changes in the levels of GSH, SOD, and TNF-α in the tissue.

[0073] Table 1. Scoring criteria for acute alcohol injury by naked eye observation

[0074]

[0075] Total score = bleeding point score + length score + (width score × 2)

[0076] 3. Experimental results

[0077] The gastric mucosa of rats in the normal group had normal morphology and color, and the mucosa was smooth, while the gastric mucosa of rats in the model group had severe bleeding, with cord-like bleeding and erosion, indicating that the model was successfully established. Compared with the model group, the gastric mucosa of animals in the low-dose group of the Chinese medicine composition had obvious congestion and edema, cord-like bleeding, and some flaky erosion, and the degree of gastric mucosal bleeding and erosion was slightly lighter than that of the model group; the gastric mucosa of animals in the medium- and high-dose groups of the Chinese medicine composition had a small amount of congestion and edema, mottled changes, scattered bleeding and erosion, but it was significantly improved compared with the model group (P<0.05, P<0.01). See Table 2.

[0078] Table 2 Effect on gastric mucosal injury score in rats (n=10)

[0079]

[0080] Compared with the normal group: ##P<0.01; compared with the model group: *P<0.05, **P<0.01

[0081] Ethanol is a common factor of gastric mucosal injury, which is highly corrosive to the gastric mucosa. After being absorbed by the stomach, it generates acetaldehyde and a variety of free radicals. These free radicals play an important role in the process of alcoholic gastric mucosal injury. MDA is a lipid peroxidation product caused by oxygen free radicals, which reflects the degree of tissue damage by free radicals to a certain extent; SOD is the most important free radical scavenger in the body and has extremely strong antioxidant activity. In addition, inflammation is an important factor in the pathogenesis of mucosal injury, and TNF-α is a key inflammatory factor that can cause inflammatory reactions. The test kit found that compared with the normal group, the levels of MDA and TNF-α in the gastric mucosal tissue of the model group were significantly increased (P<0.01, P<0.01), and the SOD enzyme activity was significantly reduced (P<0.01); compared with the model group, the low, medium and high dose groups of the Chinese medicine composition can significantly reduce the levels of MDA and TNF-α (P<0.05, P<0.01), and increase the SOD enzyme activity (P<0.05, P<0.01). See Table 3.

[0082] Table 3 Effects on the levels of MDA, GSH and TNF-α in rat gastric mucosal tissue (n=10)

[0083]

[0084]

[0085] Compared with the normal group: ##P<0.01; compared with the model group: *P<0.05, **P<0.01

[0086] The composition proposed by the present invention can significantly reduce the symptoms of gastric mucosal congestion, edema and bleeding in model rats, and can also significantly reduce the levels of MDA and TNF-α, and improve the activity of SOD enzyme, indicating that it has a significant protective effect on gastric mucosal damage in rats caused by alcohol, and can inhibit the inflammatory response of gastric mucosa and improve the antioxidant and free radical scavenging capabilities.

[0087] The above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the embodiments here. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. A Chinese medicine composition for protecting gastric mucosa, characterized in that: The invention is prepared from the following raw materials in weight proportion: 1-40 parts of oats, 1-30 parts of millet, 1-30 parts of yam, 1-20 parts of white hyacinth bean, 0.1-5 parts of hericium erinaceus, 0.1-5 parts of dendrobium officinale, 0.1-5 parts of tuckahoe and 0.1-5 parts of tremella.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises: 15-30 parts of oats, 10-20 parts of millet, 3-12 parts of yam, 2-10 parts of white hyacinth bean, 0.5-4 parts of hericium erinaceus, 0.5-4 parts of dendrobium officinale, 0.5-4 parts of tuckahoe and 0.5-4 parts of tremella.

3. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition comprises: 20-25 parts of oats, 12-15 parts of millet, 5-9 parts of yam, 2-6 parts of white hyacinth bean, 0.5-3 parts of hericium erinaceus, 0.5-3 parts of dendrobium officinale, 0.5-3 parts of tuckahoe, and 0.5-3 parts of tremella.

4. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises: 22 parts of oats, 14 parts of millet, 6 parts of yam, 4 parts of white hyacinth bean, 1 part of hericium erinaceus, 1 part of dendrobium officinale, 1 part of poria cocos, and 1 part of tremella; or 20 parts of oats, 12 parts of millet, 5 parts of yam, 2 parts of white hyacinth bean, 0.5 part of hericium erinaceus, 0.5 part of dendrobium officinale, 0.5 part of poria cocos, and 3 parts of tremella.

5. A medicine, health product or food containing the Chinese medicine composition according to any one of claims 1 to 4.

6. The drug according to claim 5, characterized in that The drug is in any pharmaceutically acceptable dosage form.

7. The drug according to claim 5, characterized in that The medicine includes granules, oral solution, tablets, capsules or pills.

8. Use of the Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a medicament for treating gastric mucosal injury or gastritis.

9. The use according to claim 8, wherein the gastric mucosal damage is gastric mucosal damage caused by alcohol.

10. The method for preparing the Chinese medicine composition according to claims 1-5, characterized in that: The method comprises the following steps: taking medicinal materials, adding 8-12 times water, and reflux extracting for 2 times, each time for 1 hour, combining the extracts, filtering, concentrating the extracts to a relative density of 1.10-1.15 at 55-60° C. to obtain a concentrated solution, centrifugally filtering the concentrated solution to obtain a concentrated solution after centrifugation, spray drying the concentrated solution, with an inlet temperature of 170-180° C. and an outlet temperature of not less than 75° C. to obtain a dry extract, and crushing and sieving the obtained dry extract as required.

Images