Preparation method and application of compound camel capsule

Abstract

The invention provides a preparation method of a compound Zhihua capsule, which comprises the following steps: by taking peganum harmala, processed semen strychni, sculellaria barbata, coix seed, toad, oldenlandia diffusa, pericarpium citri reticulatae, solanum nigrum, gynostemma pentaphyllum, radix paeoniae alba, astragalus membranaceus and liquorice as raw materials, sequentially purchasing and pretreating, extracting and separating, concentrating and drying, refining and mixing, granulating and filling into a capsule. The compound camel capsule is a novel targeted therapy tumor medicine for treating gastric cancer, intestinal cancer and other digestive systems, and the medicine has super-strong penetrability, and can quickly penetrate into body tissues, act on tumor focuses, combine with tumor cell DNA (deoxyribonucleic acid), prevent the tumor cell DNA from being copied, inhibit tumor cell growth and soften hyperplastic tissues.

Description

Technical Field

[0001] The invention relates to the technical field of compound qiantuan (mossroots herb) and in particular to a preparation method and application of a compound qiantuan (mossroots herb) capsule. Background Art

[0002] Gastrointestinal tumors refer to tumor diseases that occur in the digestive tract, including tumors in the esophagus, stomach, small intestine, large intestine, rectum and anus. These tumors can be divided into two types: benign and malignant. Common digestive tract tumors include esophageal tumors, stomach tumors, intestinal tumors, liver tumors, etc. Early detection and treatment of digestive tract tumors are crucial to the patient's survival rate and quality of life. Common early symptoms include indigestion, stomach pain, abdominal distension, loss of appetite, abnormal bowel movements, black stools, etc.

[0003] Compound Qiantuo Capsule is a traditional Chinese medicine preparation, which is mainly used for the treatment or auxiliary treatment of diseases such as digestive tract tumors. Currently, there is no preparation method for Compound Qiantuo Capsule on the market. Summary of the invention

[0004] In order to solve the above problems, the present invention discloses a preparation method and application of compound Qiantu capsule.

[0005] The specific plan is as follows: A preparation method of compound Qiantuo capsules is characterized in that camel thorn fruit, processed strychnos nux vomica, Scutellaria barbata, coix seeds, toad, oldenlandia diffusa, tangerine peel, Solanum nigrum, Gynostemma pentaphyllum, white peony root, astragalus and liquorice are used as raw materials, and the raw materials are purchased and pretreated, extracted and separated, concentrated and dried, refined and mixed, granulated and capsule filled in sequence.

[0006] As a further improvement of the present invention, the procurement and pretreatment include raw material procurement, raw material inspection and pretreatment, the raw material procurement is to purchase the required number of camel thorn fruit, processed horse chestnut seed, Scutellaria barbata, coix seed, toad, oldenlandia diffusa, tangerine peel, Solanum nigrum, Gynostemma pentaphyllum, white peony root, astragalus and licorice; the raw material inspection is to detect the appearance, odor, moisture, ash content, and extract content of the purchased raw materials, wherein the moisture index is 7-13%; the pretreatment is to wash, remove impurities, slice, crush and set aside the qualified raw materials.

[0007] As a further improvement of the present invention, the extraction and separation include extraction and separation treatment, the extraction treatment is to extract the effective ingredients in the pretreated spare Chinese medicinal materials by ultrasonic extraction method, the temperature is 40-65°C, the time is 20-40 minutes, and the equipment used in the separation treatment is a filter and a centrifuge.

[0008] As a further improvement of the present invention, the concentration and drying include concentration and drying treatment, the concentration treatment adopts thin film concentration, the packing density of the membrane device is 7-8%, the upstream flow rate is fixed at 0.6m / s, the absolute pressure on the downstream side of the membrane is maintained at 40mmHg, the temperature is 36-57°C, and the drying treatment adopts vacuum drying and freeze drying.

[0009] As a further improvement of the present invention, the refining and mixing include refining and mixing treatments, wherein the refining treatment adopts a recrystallization method to remove impurities and improve purity; and the mixing adopts a high-efficiency mixing mechanism to evenly mix the refined drug powder with the filler and disintegrant.

[0010] As a further improvement of the present invention, the high-efficiency mixing mechanism includes a shell, a mixing barrel is arranged in the shell, the mixing barrel is a cylindrical structure with an open upper end, four stirring shafts are evenly distributed in the interior along the circumferential direction, the stirring shafts are arranged in the radial direction, and a plurality of stirring paddles are arranged in sequence, the stirring paddles on each stirring shaft gradually increase from the inside to the outside, and rotating teeth are arranged at the rear end of the stirring shaft, each rotating tooth is meshed on a gear ring, and a rotating shaft for driving the mixing barrel to rotate is provided in the middle of the bottom surface.

[0011] As a further improvement of the present invention, the granulation and capsule filling include granulation and capsule filling, wherein the granulation is to form granules by a granulator with uniformly mixed drug powder; the capsule filling is to fill the prepared granules into a capsule shell to form a compound Qiantuo capsule; during the filling process, the difference in the amount of each capsule is controlled to ensure the accuracy of the drug dosage. At the same time, the capsule is visually inspected to ensure that the capsule shell is intact and not damaged.

[0012] As a further improvement of the present invention, it also includes packaging and quality control, wherein packaging is to seal the filled capsules; quality control is to perform quality control and inspection at various stages of the preparation process, including physical and chemical indicators, microbial limits, and content determination inspection methods.

[0013] The invention discloses an application of a compound Qiantuo capsule. The compound Qiantuo capsule prepared by the method is used as a targeted drug in the digestive system for treating gastric cancer and intestinal cancer.

[0014] The beneficial effects of the present invention are as follows: the prepared compound Qiantuo capsule is a new drug for targeted therapy of tumors of the digestive system such as gastric cancer and intestinal cancer. The drug has super strong penetrability, can quickly penetrate into body tissues, act on tumor lesions, combine with tumor cell DNA, prevent its replication, inhibit tumor cell growth, and soften hyperplastic tissue. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the efficient mixing mechanism in the present invention.

[0016] Figure 2 for Figure 1 Top view of the internal structure.

[0017] List of reference numerals: 1-Mixing barrel, 2-Stirring shaft, 3-Stirring paddle, 4-Gear, 5-Gear ring. DETAILED DESCRIPTION

[0018] The present invention will be further explained below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention.

[0019] The invention provides a preparation method of compound money capsules. The raw materials are camel thorn fruit, processed strychnos nux vomica, Scutellaria barbata, coix seeds, toad, oldenlandia diffusa, tangerine peel, Solanum nigrum, Gynostemma pentaphyllum, white peony root, astragalus and liquorice, and the raw materials are purchased and pretreated, extracted and separated, concentrated and dried, refined and mixed, granulated and capsule filled in sequence.

[0020] In this embodiment, the procurement and pretreatment include raw material procurement, raw material inspection and pretreatment. The raw material procurement is to purchase the required number of camel thorn fruit, processed strychnos nux vomica, Scutellaria barbata, coix seed, toad, oldenlandia diffusa, tangerine peel, Solanum nigrum, Gynostemma pentaphyllum, white peony root, astragalus and licorice; the raw material inspection is to detect the appearance, odor, moisture, ash content and extract content of the purchased raw materials, wherein the moisture index is 7-13%; the pretreatment is to wash, remove impurities, slice, crush and set aside the qualified raw materials.

[0021] In this embodiment, the extraction and separation include extraction and separation treatment, the extraction treatment is to extract the effective ingredients in the pretreated spare Chinese medicinal materials through ultrasonic extraction method, the temperature is 40-65°C, the time is 20-40min, and the equipment used in the separation treatment is a filter and a centrifuge.

[0022] In this embodiment, the concentration and drying include concentration and drying treatments, the concentration treatment uses thin film concentration, the packing density of the membrane device is 7-8%, the upstream flow rate is fixed at 0.6 m / s, the absolute pressure on the downstream side of the membrane is maintained at 40 mmHg, the temperature is 36-57°C, and the drying treatment uses vacuum drying and freeze drying.

[0023] In this embodiment, the refining and mixing include refining and mixing treatments, wherein the refining treatment uses a recrystallization method to remove impurities and improve purity; and the mixing uses a high-efficiency mixing mechanism to evenly mix the refined drug powder with the filler and disintegrant.

[0024] In the present embodiment, the high-efficiency mixing mechanism comprises a shell, a mixing barrel (1) is arranged in the shell, the mixing barrel (1) is a cylindrical structure with an open top, four stirring shafts (2) are evenly distributed in the circumferential direction inside the mixing barrel, the stirring shafts (2) are arranged in the radial direction, and a plurality of stirring paddles (3) are arranged in sequence, the stirring paddles on each stirring shaft gradually increase from the inside to the outside, and rotating teeth (4) are arranged at the rear end of the stirring shaft, each rotating tooth (4) is meshed with a gear ring (5), and a rotating shaft for driving the mixing barrel (1) to rotate is arranged in the middle of the bottom surface.

[0025] In this embodiment, the granulation and capsule filling include granulation and capsule filling, wherein the granulation is to form granules by a granulator from the uniformly mixed drug powder; the capsule filling is to fill the prepared granules into the capsule shell to form the compound Qiantuo capsule; during the filling process, the difference in the amount of each capsule is controlled to ensure the accuracy of the drug dosage. At the same time, the appearance of the capsule is inspected to ensure that the capsule shell is intact and not damaged.

[0026] In this embodiment, packaging and quality control are also included, wherein packaging is to seal the filled capsules; quality control is to perform quality control and inspection at various stages of the preparation process, including physical and chemical indicators, microbial limits, and content determination inspection methods.

[0027] The present invention also provides an application of the compound Qiantuo capsule. The prepared compound Qiantuo capsule is used as a targeted drug for the treatment of gastric cancer and intestinal cancer in the digestive system.

[0028] The technical means disclosed in the scheme of the present invention are not limited to the technical means disclosed in the above-mentioned implementation mode, but also include technical schemes composed of any combination of the above-mentioned technical features. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications are also regarded as the protection scope of the present invention.

Claims

1. A method for preparing a compound Qiantuo capsule, characterized in that: Using camel thorn fruit, processed strychnos nux vomica, Scutellaria barbata, coix seed, toad, oldenlandia diffusa, tangerine peel, Solanum nigrum, Gynostemma pentaphyllum, white peony root, astragalus and liquorice as raw materials, the process is followed in sequence: procurement and pretreatment, extraction and separation, concentration and drying, refining and mixing, granulation and capsule filling.

2. The method for preparing the compound Qiantuo capsule according to claim 1, characterized in that: The procurement and pretreatment include raw material procurement, raw material inspection and pretreatment. The raw material procurement is to purchase the required number of camel thorn fruit, processed strychnos nux vomica, Scutellaria barbata, coix seed, toad, oldenlandia diffusa, tangerine peel, Solanum nigrum, Gynostemma pentaphyllum, white peony root, astragalus and liquorice; the raw material inspection is to test the appearance, odor, moisture, ash content and extract content of the purchased raw materials, among which the moisture index is 7-13%; the pretreatment is to wash, remove impurities, slice, crush and set aside the qualified raw materials.

3. The method for preparing the compound Qiantuo capsule according to claim 2, characterized in that: The extraction and separation include extraction and separation treatments. The extraction treatment is to extract the effective ingredients from the pretreated reserve Chinese medicinal materials by ultrasonic extraction method, the temperature is 40-65°C, the time is 20-40 minutes, and the equipment used in the separation treatment is a filter and a centrifuge.

4. The method for preparing the compound Qiantuo capsule according to claim 3, characterized in that: The concentration and drying include concentration and drying treatments. The concentration treatment uses thin film concentration. The packing density of the membrane device is 7-8%. The flow rate on the upstream side is fixed at 0.6 m / s. The absolute pressure on the downstream side of the membrane is maintained at 40 mmHg. The temperature is 36-57°C. The drying treatment uses vacuum drying and freeze drying.

5. The method for preparing the compound Qiantuo capsule according to claim 4, characterized in that: The refining and mixing include refining and mixing treatments. The refining treatment adopts a recrystallization method to remove impurities and improve purity. The mixing adopts a high-efficiency mixing mechanism to evenly mix the refined drug powder with the filler and disintegrant.

6. The method for preparing the compound Qiantuo capsule according to claim 5, characterized in that: The high-efficiency mixing mechanism includes a shell, a mixing barrel is arranged in the shell, the mixing barrel is a cylindrical structure with an open upper end, four stirring shafts are evenly distributed in the circumferential direction inside the mixing barrel, the stirring shafts are arranged in the radial direction, and a plurality of stirring paddles are arranged in sequence, the stirring paddles on each stirring shaft gradually increase from the inside to the outside, and rotating teeth are arranged at the rear end of the stirring shaft, and each rotating tooth is meshed on a gear ring.

7. The method for preparing the compound Qiantuo capsule according to claim 6, characterized in that: The granulation and capsule filling process includes granulation and capsule filling. The granulation process is to make uniformly mixed drug powder into granules by a granulator. The capsule filling process is to fill the prepared granules into the capsule shell to form the compound Qiantuo capsule. During the filling process, the difference in the amount of each capsule is controlled to ensure the accuracy of the drug dosage. At the same time, the appearance of the capsule is inspected to ensure that the capsule shell is intact and not damaged.

8. The method for preparing the compound Qiantuo capsule according to claim 7, characterized in that: It also includes packaging and quality control, among which packaging is the sealed packaging of filled capsules; quality control is quality control and inspection at various stages of the preparation process, including physical and chemical indicators, microbial limits, and content determination inspection methods.

9. An application of compound Qiantuo capsule, characterized in that: The compound Qiantuo capsule prepared by the method according to any one of claims 1 to 8 is used as a targeted drug in the digestive system for treating gastric cancer and intestinal cancer.

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