Skin barrier repair dressing and preparation method thereof

Abstract

The invention belongs to the technical field of functional dressings, and discloses a skin barrier repair dressing and a preparation method thereof. The skin barrier repair dressing is prepared from the following raw materials in percentage by weight: 0.1 to 5 percent of macromolecular hyaluronic acid, 0.1 to 5 percent of middle molecular hyaluronic acid, 0.01 to 1 percent of oligomeric sodium hyaluronate, 0.1 to 5 percent of cationic guar gum, 0.1 to 6 percent of micromolecular recombinant humanized collagen, 0.5 to 8 percent of L-lactic acid, 0.05 to 0.2 percent of sodium ethylparaben and the balance of pure water. The components of the dressing are reasonably proportioned and synergistically gained, a protective barrier can be provided for skin, repairing of the skin barrier function is effectively promoted through a multi-layer moisturizing and repairing mechanism, and meanwhile the dressing has good comfort, safety and environment friendliness.

Description

Technical Field

[0001] The present invention relates to the technical field of functional dressings, and in particular to a skin barrier repairing dressing and a preparation method thereof. Background Art

[0002] The skin is the main barrier that protects the internal tissues of the human body from damage by the external environment. It can block the invasion of pathogenic microorganisms and prevent the loss of body fluids. Currently, skin barrier damage is a common problem faced in the field of medical beauty and other skin injuries (dermatitis / eczema, moderate acne, etc.). Although the skin has the ability to repair itself naturally, the natural healing process of damaged skin barrier is a complex and slow process. During the natural healing period, the skin may continue to be dry and sensitive, and even have complications such as itching, inflammation, and infection. Complications such as inflammation and infection will further affect the skin's repair process and may cause pigmentation or scar formation. The use of repair products can provide additional support for skin barrier repair, help the skin resume normal function faster, and reduce the occurrence of complications.

[0003] However, the current skin barrier repair dressings have relatively single functions and low utilization of effective ingredients. Most products are insufficient in terms of both continuous moisturizing and rapid repair. In addition, the product's safety, degradability and comfort level still need to be further improved. Therefore, the development of skin barrier repair dressings with significant efficacy, safe use, comfortable skin feel and environmental friendliness has broad market prospects. Summary of the invention

[0004] 1. Technical issues to be resolved In view of this, the present invention proposes a skin barrier repair dressing and a preparation method thereof. The dressing obtains a skin barrier repair dressing with more significant effectiveness, safety and comfort by rationally proportioning active substances with different functions and different molecular weights, thereby meeting the care needs of different skin problems.

[0005] (II) Technical solution The technical solution of the present invention is as follows: A skin barrier repair dressing is made of the following raw materials in percentage by weight: 0.1% to 5% high molecular weight hyaluronic acid, 0.1% to 5% medium molecular weight hyaluronic acid, 0.01% to 1% oligomeric sodium hyaluronate, 0.1% to 5% cationic guar gum, 0.1% to 6% small molecular weight recombinant humanized collagen, 0.5% to 8% L-lactic acid, 0.05% to 0.2% sodium ethylparaben, and the balance is pure water.

[0006] Optionally, the molecular weight of the high molecular weight hyaluronic acid is 1.2 to 2 million Da, and the molecular weight of the medium molecular weight hyaluronic acid is 300,000 to 1 million Da.

[0007] Preferably, the molecular weight of the high molecular weight hyaluronic acid is 1.4 to 1.6 million Da, and the molecular weight of the medium molecular weight hyaluronic acid is 400,000 to 600,000 Da.

[0008] Preferably, the molecular weight of the oligomeric sodium hyaluronate is less than 10,000 Da.

[0009] Preferably, the small molecule recombinant humanized collagen is small molecule recombinant humanized type III collagen with a molecular weight of 500-2000 Da.

[0010] As a preferred embodiment of the present invention, the above-mentioned skin barrier repair dressing is made of the following raw materials in percentage by weight: 0.1% to 1% high molecular weight hyaluronic acid, 0.1% to 1% medium molecular weight hyaluronic acid, 0.01% to 0.2% oligomeric sodium hyaluronate, 0.1% to 1% cationic guar gum, 0.5% to 2% small molecule recombinant humanized collagen, 0.5%-3% L-lactic acid, 0.1% to 0.15% sodium ethylparaben, and the balance is pure water.

[0011] Further preferably, the above-mentioned skin barrier repair dressing is made of the following raw materials in percentage by weight: 0.5% high molecular weight hyaluronic acid, 1% medium molecular weight hyaluronic acid, 0.1% oligomeric sodium hyaluronate, 0.5% cationic guar gum, 1.2% small molecule recombinant humanized collagen, 1% L-lactic acid, 0.15% sodium ethyl hydroxybenzoate, and the balance is pure water.

[0012] The present invention also provides a method for preparing a skin barrier repair dressing, comprising the following steps: S1: Disperse the cationic guar gum evenly in cold pure water, let it stand and wait for it to swell naturally to form a transparent cationic guar gum gel solution for standby use; S2: Dissolve high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid, oligomeric sodium hyaluronate, small molecular weight recombinant humanized collagen, and L-lactic acid in the remaining amount of pure water and stir until completely dissolved; S3: Add the cationic guar gum gel solution in S1 to the solution prepared in S2, and add sodium ethylparaben, mix well and stir thoroughly to homogenize.

[0013] S4: The obtained gel solution is subjected to ultrasonic treatment to remove bubbles, and then packaged and sterilized by irradiation.

[0014] Preferably, in steps S2 and S3, the stirring speed is 3000-6000 rpm, the stirring temperature is 30-40° C., and the stirring time is 30-60 min.

[0015] The beneficial effects are: setting the heating temperature can speed up the dissolution rate of each substance, while avoiding the influence of too high temperature on the activity of the effective components. Setting the stirring speed can improve the mixing efficiency of each component, ensure the mixing effect, while avoiding the reduction of the activity of the effective components due to the shear force of high-speed stirring. At the same time, setting the appropriate stirring temperature and speed can shorten the stirring time, which is conducive to reducing the risk of contamination by external factors such as microorganisms, and better improving production safety.

[0016] Preferably, the radiation source for radiation sterilization in step S4 is cobalt-60, the dose is 25-40 kGy, and the sterilization time is 4-6 hours.

[0017] The beneficial effect is that inactivating microorganisms under appropriate conditions can ensure that the skin dressing reaches a sterile state before use without significantly affecting the active substances, while maintaining the performance and safety of the dressing.

[0018] The various ingredients in the present invention are as follows: High-molecular-weight hyaluronic acid has a strong moisturizing ability. It can form a moisturizing breathable film on the skin surface through the mutual entanglement between molecules, thereby preventing the loss of skin moisture and resisting external stimuli and pollutants, providing a favorable environment for skin repair. However, due to its large molecular weight, high-molecular-weight hyaluronic acid is not easy to penetrate into the deep layers of the skin. It mainly acts on the surface of the skin to provide an immediate moisturizing effect.

[0019] Medium-molecular hyaluronic acid can penetrate into the middle layer of the skin to replenish water, improve the skin's internal hydration, and provide the skin with more comprehensive moisturizing and soothing effects, thereby improving the skin's overall elasticity and texture.

[0020] Oligomeric sodium hyaluronate has a small molecular weight and can be quickly absorbed by the skin and enter deep into the skin through pores and intercellular spaces, exerting a deep moisturizing effect. In addition, oligomeric sodium hyaluronate has certain anti-inflammatory, soothing, and skin cell repair and regeneration effects, which helps to enhance the skin's barrier function and is suitable for sensitive or damaged skin.

[0021] Cationic guar gum is a modified polysaccharide based on guar gum, rich in hydroxyl and quaternary ammonium groups. Hydroxyl groups are highly hydrophilic and can form hydrogen bonds with water molecules, making cationic guar gum have good moisturizing properties. Quaternary ammonium groups give cationic guar gum cationic properties, which can interact with negatively charged groups on skin surface proteins, improve the adhesion of cationic guar gum on the skin, and form a stable film on the skin surface, thereby reducing water loss and resisting external stimuli. In addition, the cationic properties of cationic guar gum make it inhibit microorganisms, help reduce bacterial growth and reduce the risk of skin infection. Therefore, the application of cationic guar gum in skin dressings can provide deep nourishment, improve skin texture, enhance skin barrier function, and is suitable for use in a variety of skin care products.

[0022] Recombinant humanized collagen is a full-length or partial amino acid sequence fragment encoded by a specific type of human collagen gene prepared by DNA recombination technology, or a combination of human collagen fragments. It has excellent biocompatibility and functionality, can promote skin repair, enhance skin elasticity, improve skin texture, and enhance skin barrier function, and has a good improvement effect on skin damage, skin inflammation and sensitive skin. Small molecule recombinant humanized collagen is formed by the hydrolysis of recombinant humanized collagen, has a smaller molecular weight, and is easier to penetrate into the deep layers of the skin, promoting the repair and regeneration of skin cells.

[0023] L-lactic acid, also known as alpha-hydroxy acid (AHA), is a naturally occurring organic acid that is usually derived from lactose fermentation and metabolized as a normal carbonate compound in the skin. L-lactic acid can dissolve the adhesive substances between the keratinocytes on the surface of the skin, promote the shedding of dead skin cells, and play a mild exfoliating role, thereby stimulating the metabolism of the skin, promoting the regeneration of skin cells, and improving dull and rough skin. The exfoliating effect of L-lactic acid can also help other active ingredients better penetrate into the deep layers of the skin, thereby improving the overall skin care effect. In addition, L-lactic acid can also help strengthen the skin's barrier function, improve the skin's ability to resist external stimuli, and reduce the occurrence of skin sensitivity and allergies.

[0024] Sodium ethylparaben is a commonly used preservative that can effectively inhibit the growth of microorganisms, has low skin irritation, and ensures the safety and stability of the product.

[0025] Compared with the prior art, the present invention has the following beneficial effects: 1. The skin barrier repair dressing provided by the present invention rationally mixes active substances of different functions and different molecular weights to form a multi-level moisturizing and repair system. High molecular weight hyaluronic acid and cationic guar gum form a long-lasting protective film on the surface of the skin through electrostatic interaction, preventing skin moisture loss and resisting external stimuli and pollutants, while helping to maintain the stability and sustained release of small molecule substances. Medium molecular weight hyaluronic acid penetrates into the middle layer of the skin to provide deep moisturizing and improve the internal hydration of the skin. Small molecule substances such as oligomeric sodium hyaluronate, small molecule recombinant humanized collagen and L-lactic acid penetrate deep into the bottom layer of the skin to exert anti-inflammatory, moisturizing and promote skin cell repair and regeneration. This multi-level repair mechanism can effectively promote the repair of skin barrier function in a short time, thereby improving skin texture and promoting skin health.

[0026] 2. The present invention optimizes the ratio of each component, and the prepared skin barrier repair dressing is in the form of a transparent, viscous gel solution with good fluidity, fine texture, and moderate viscosity. It ensures excellent repair effect while having a comfortable skin feel.

[0027] 3. The skin barrier repair dressing prepared by the present invention has a simple formula, the ingredients have strong targeted efficacy, and the preparation process adopts a sterile guarantee process. The obtained product is highly safe, mild, non-irritating and environmentally friendly. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0029] Figure 1 The antibacterial performance test results of the skin barrier repair dressing, a is the colony picture of the antibacterial experiment, and b is the bacterial survival rate; Figure 2 The effect of skin barrier repair dressing on the migration of human umbilical vein endothelial cells (HUVECs), a is the cell migration picture in the cell migration test, b is the cell migration rate; Figure 3 The results of cytocompatibility testing of skin barrier repair dressings; DETAILED DESCRIPTION

[0030] The technical solution of this patent is further described in detail below in conjunction with specific implementation methods.

[0031] The raw materials used in the examples are all commercially available products.

[0032] [Example 1] A skin barrier repair dressing is made of the following raw materials in percentage by weight: 1% high molecular weight hyaluronic acid, 1% medium molecular weight hyaluronic acid, 0.3% oligomeric sodium hyaluronate, 0.1% cationic guar gum, 3% small molecular weight recombinant humanized collagen, 0.5% L-lactic acid, 0.15% sodium ethylparaben, and the balance is pure water.

[0033] The molecular weight of high molecular weight hyaluronic acid is 1.5 million Da; the molecular weight of medium molecular weight hyaluronic acid is 600,000 Da; the molecular weight of oligomeric sodium hyaluronate is 5000~10000 Da; Among them, the small molecule recombinant humanized collagen is type III collagen; the molecular weight is 500~2000 Da.

[0034] [Example 2] A skin barrier repair dressing is made of the following raw materials in percentage by weight: 0.1% high molecular weight hyaluronic acid, 0.1% medium molecular weight hyaluronic acid, 0.01% oligomeric sodium hyaluronate, 3% cationic guar gum, 0.5% small molecular weight recombinant humanized collagen, 3% L-lactic acid, 0.15% sodium ethyl hydroxybenzoate, and the balance is pure water.

[0035] The molecular weight of high molecular weight hyaluronic acid is 1.5 million Da; the molecular weight of medium molecular weight hyaluronic acid is 600,000 Da; the molecular weight of oligomeric sodium hyaluronate is 5000~10000 Da; Among them, the small molecule recombinant humanized collagen is type III collagen; the molecular weight is 500~2000 Da.

[0036] [Example 3] A skin barrier repair dressing is made of the following raw materials in percentage by weight: 0.5% high molecular weight hyaluronic acid, 1% medium molecular weight hyaluronic acid, 0.1% oligomeric sodium hyaluronate, 0.5% cationic guar gum, 1.2% small molecular weight recombinant humanized collagen, 1% L-lactic acid, 0.15% sodium ethylparaben, and the balance is pure water.

[0037] The molecular weight of high molecular weight hyaluronic acid is 1.5 million Da; the molecular weight of medium molecular weight hyaluronic acid is 600,000 Da; the molecular weight of oligomeric sodium hyaluronate is 5000~10000 Da; Among them, the small molecule recombinant humanized collagen is type III collagen; the molecular weight is 500~2000 Da.

[0038] [Example 4] A skin barrier repair dressing is made of the following raw materials in percentage by weight: 0.5% high molecular weight hyaluronic acid, 1% medium molecular weight hyaluronic acid, 0.1% oligomeric sodium hyaluronate, 0.5% cationic guar gum, 1.2% small molecular weight recombinant humanized collagen, 1% L-lactic acid, 0.15% sodium ethylparaben, and the balance is pure water.

[0039] The molecular weight of high molecular weight hyaluronic acid is 1.2 million Da; the molecular weight of medium molecular weight hyaluronic acid is 300,000 Da; the molecular weight of oligomeric sodium hyaluronate is 5000~10000 Da; Among them, the small molecule recombinant humanized collagen is type III collagen; the molecular weight is 500~2000 Da.

[0040] [Example 5] A skin barrier repair dressing is made of the following raw materials in percentage by weight: 0.5% high molecular weight hyaluronic acid, 1% medium molecular weight hyaluronic acid, 0.1% oligomeric sodium hyaluronate, 0.5% cationic guar gum, 1.2% small molecular weight recombinant humanized collagen, 1% L-lactic acid, 0.15% sodium ethylparaben, and the balance is pure water.

[0041] The molecular weight of high molecular weight hyaluronic acid is 2 million Da; the molecular weight of medium molecular weight hyaluronic acid is 800,000 Da; the molecular weight of oligomeric sodium hyaluronate is 5000~10000 Da; Among them, the small molecule recombinant humanized collagen is type III collagen; the molecular weight is 500~2000 Da.

[0042] The above-mentioned embodiments 1 to 5 adopt the following preparation method: S1: Disperse the cationic guar gum evenly in cold pure water, let it stand and wait for it to swell naturally to form a transparent cationic guar gum gel solution for standby use; S2: Dissolve high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid, oligomeric sodium hyaluronate, small molecular weight recombinant humanized collagen, and L-lactic acid in the remaining amount of pure water, and stir at 5000 rpm and 37 °C for 40 min to completely dissolve them; S3: Add the cationic guar gum gel solution in S1 to the solution prepared in S2, mix well, then add sodium ethylparaben, and stir at 5000 rpm and 37 °C for 40 min to homogenize. S4: The obtained gel solution is ultrasonically removed of bubbles, and after packaging, it is sterilized by radiation with cobalt-60 at a dose of 30 kGy and a sterilization time of 4 hours.

[0043] [Example 6] The difference between this embodiment and embodiment 3 is: a skin barrier repair dressing and a preparation method thereof, in steps S2 and S3, the stirring speed is 8000 rpm, the stirring temperature is 25°C, and the stirring time is 60 min.

[0044] [Example 7] The difference between this embodiment and embodiment 3 is: a skin barrier repair dressing and a preparation method thereof, in steps S2 and S3, the stirring speed is 1000 rpm, the stirring temperature is 60° C., and the stirring time is 60 min.

[0045] [Example 8] The difference between this embodiment and embodiment 3 is: a skin barrier repair dressing and a preparation method thereof, in the step S4, the radiation sterilization dose is 20, and the sterilization time is 12 hours.

[0046] [Example 9] The difference between this embodiment and embodiment 3 is: a skin barrier repair dressing and a preparation method thereof, in the step S4, the radiation sterilization dose is 60, and the sterilization time is 2 hours.

[0047] [Comparative Example 1] The difference between this comparative example and Example 3 is that the skin barrier repair dressing does not contain high-molecular hyaluronic acid and medium-molecular hyaluronic acid.

[0048] [Comparative Example 2] The difference between this comparative example and Example 3 is that the skin barrier repair dressing does not contain oligomeric sodium hyaluronate.

[0049] [Comparative Example 3] The difference between this comparative example and Example 3 is that the skin barrier repair dressing does not contain cationic guar gum.

[0050] [Comparative Example 4] The difference between this comparative example and Example 3 is that the skin barrier repair dressing does not contain small molecule recombinant humanized collagen.

[0051] [Comparative Example 5] The difference between this comparative example and Example 3 is that the skin barrier repair dressing does not contain L-lactic acid.

[0052] [Test Example 1] The skin barrier repair dressing was tested for sterility according to the method specified in Appendix XII A of Part III of the Pharmacopoeia of the People's Republic of China (2010 edition). Specifically, after unpacking the product package, an appropriate amount of the dressing sample was applied to the LB agar medium by direct contact method, and placed in a 37°C incubator for culture, and observed for 14 consecutive days. The results showed that no microbial colony growth was observed in the sample culture dishes of Examples 1 to 9 and Comparative Examples 1 to 5, indicating that the skin barrier repair dressing prepared by the present invention meets the sterility requirements.

[0053] [Test Example 2] The appearance and texture of the skin barrier repair dressings prepared in Examples 1 to 9 and Comparative Examples 1 to 5 were evaluated. The evaluation method was: observing the morphology and texture of the repair dressings, excellent (transparent gel solution, fine and uniform texture, moderate viscosity), better (transparent gel solution, fine and uniform texture, slightly thick or slightly thin viscosity), poor (transparent gel solution, (local) uneven texture, too thick or too thin viscosity), and the evaluation results were ranked according to the rating structure: excellent > better > poor. The results are shown in Table 1.

[0054] Table 1 Appearance and texture evaluation results of Examples 1 to 10 Group evaluate Group evaluate Example 1 excellent Example 8 excellent Example 2 Poor Example 9 excellent Example 3 excellent Comparative Example 1 Better Example 4 Better Comparative Example 2 excellent Example 5 Better Comparative Example 3 Better Example 6 Poor Comparative Example 4 excellent Example 7 Poor Comparative Example 5 excellent [Test Example 3] The antibacterial performance of the skin barrier repair dressing prepared in Example 3 was tested. Escherichia coli and Staphylococcus aureus were inoculated into LB culture medium and cultured until the bacterial concentration was 1×10 5 CFU / mL. Take 1 mL of skin barrier repair dressing and add it to 9 mL of bacterial suspension. The control group uses 1 mL of LB culture medium instead of skin barrier repair dressing. After co-culture in a 37℃ shaker for 8 hours, take the bacterial suspension and dilute it and spread it on LB agar medium. After culturing in a 37℃ incubator for 24 hours, observe the growth of colonies. The results are as follows Figure 1 shown.

[0055] [Test Example 4] The effects of the skin barrier repair dressings prepared in Examples 1 to 3 on HUVECs cell migration were tested to evaluate their effects on promoting skin barrier repair. HUVECs were cultured in a 24-well plate. When the cell confluence reached 90% to 95%, a scratch area was made with a sterile plastic pipette tip. The culture medium containing the skin barrier repair dressing was then replaced and culture was continued for 24 h. An inverted microscope was used to observe the distance that the cells moved from the scratch edge to evaluate the migration of the cells. The results are shown in Figure 2. Figure 2 shown.

[0056] [Test Example 5] The skin barrier repair dressings prepared in Examples 1 to 3 were subjected to a cell compatibility test. 100 μL of HUVECs suspension (about 5000 cells) was inoculated into a 96-well culture plate. After cell adhesion, the culture medium containing the skin barrier repair dressing was replaced, and the activity of the cells was detected by CCK8 test after 1, 3, and 5 days of culture. The results are shown in FIG. Figure 3 shown.

[0057] [Test Example 6] The film-forming and moisturizing properties of the skin barrier repair dressing were tested. 10 volunteers with dry skin were randomly selected. After cleaning the inside of the volunteers' arms, 14 1cm*1cm squares were marked on the inside of the arms. The skin barrier repair dressings of Examples 1 to 9 and Comparative Examples 1 to 5 were applied to the squares on the inside of the volunteers' arms in sequence. The volunteers were asked to sit quietly in an environment without direct sunlight, no wind, temperature of 22°C, and humidity of 40% to 50%. The transepidermal water loss value (TEWL) was tested by VAPOSCAN AS-VT100RS transepidermal water loss measuring instrument 1 hour, 3 hours, and 6 hours after applying the samples.

[0058] Transepidermal water loss change = TEWL measurement value of the sample group minus TEWL measurement value of the blank group. The blank group is the skin data of the inner side of the arm without skin barrier repair dressing. The results are shown in Table 2.

[0059] Table 2 Transepidermal water loss changes of skin barrier repair dressings (g / m 2 / h) Group 1 hour 3 hours 6 hours Example 1 -9.31±4.98 -8.86±3.65 -8.41±3.72 Example 2 -9.75±5.32 -9.13±8.38 -8.59±3.24 Example 3 -9.81±4.63 -9.37±5.23 -8.99±3.98 Example 4 -9.79±3.84 -9.04±6.33 -8.57±3.42 Example 5 -9.62±4.89 -9.19±6.70 -8.44±5.21 Example 6 -9.01±3.32 -8.66±2.31 -8.03±4.22 Example 7 -8.83±2.68 -8.31±5.21 -7.93±5.27 Example 8 -9.78±3.89 -9.21±4.89 -9.01±4.12 Example 9 -9.13±5.53 -8.78±3.79 -8.22±2.10 Comparative Example 1 -7.86±3.78 -6.12±4.57 -5.01±4.51 Comparative Example 2 -7.55±4.31 -6.34±4.42 -5.76±3.89 Comparative Example 3 -7.77±3.77 -6.57±3.91 -5.32±4.02 Comparative Example 4 -8.25±5.12 -7.76±4.70 -7.03±4.32 Comparative Example 5 -8.42±4.61 -7.87±3.29 -7.31±2.99 [Test Example 4] Testing the skin repair effect of the skin barrier repair dressing: 50 volunteers were randomly selected, and mild laser burns were performed on the inner side of the volunteers' arms. The skin barrier repair dressings of Examples 1 to 9 and Comparative Examples 1 to 5 were tested on the patients with laser burns.

[0060] Usage: After cleaning the affected area, apply the repair dressing to the affected area and gently massage until absorbed, once in the morning and evening. After 3 days of use, record the efficacy. The control group does not use the repair dressing.

[0061] Effect measurement: The patient's laser burn site healed more than 90% and the pain relief rate was more than 80%, which was considered effective.

[0062] Skin feel score: The user scores the skin comfort of the dressing, with a full score of 10. The higher the score, the higher the comfort.

[0063] The results are shown in Table 3.

[0064] Table 3 Skin repair effect of skin barrier repair dressing It can be seen from the above test results that the skin barrier repair dressing of the present invention can effectively resist bacterial invasion, relieve pain and promote skin barrier repair, and is comfortable to use, highly safe and has no adverse reactions. Among them, Example 3 has the best appearance texture and moisturizing and repairing effect. Compared with Comparative Examples 1 to 5, Examples 1 to 9 add high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid, oligomeric sodium hyaluronate, cationic guar gum, small molecule recombinant humanized collagen, and L-lactic acid to improve the moisturizing and repairing properties of the dressing. Compared with Examples 1, 2, 4, and 5, Example 3 improves the appearance, texture, and moisturizing and repairing effects of the dressing by adjusting the specific amount and molecular weight of the components. Compared with Examples 6 to 9, Example 3 promotes the dissolution and homogenization of each component by adjusting the specific process parameters in the preparation process, improves the appearance and texture of the dressing, and improves safety while maintaining the overall performance of the dressing.

[0065] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A skin barrier repair dressing, characterized in that: It is made of the following raw materials in percentage by weight: 0.1% to 5% high molecular weight hyaluronic acid, 0.1% to 5% medium molecular weight hyaluronic acid, 0.01% to 1% oligomeric sodium hyaluronate, 0.1% to 5% cationic guar gum, 0.1% to 6% small molecular weight recombinant humanized collagen, 0.5% to 8% L-lactic acid, 0.05% to 0.2% sodium ethylparaben, and the balance is pure water.

2. A skin barrier repair dressing according to claim 1, characterized in that: It is made of the following raw materials in percentage by weight: high molecular weight hyaluronic acid 0.1-1%, medium molecular weight hyaluronic acid 0.1-1%, oligomeric sodium hyaluronate 0.01%-0.2%, cationic guar gum 0.1%-1%, small molecule recombinant humanized collagen 0.5%-2%, L-lactic acid 0.5%-3%, sodium ethylparaben 0.1-0.15%, and the balance is pure water.

3. The skin barrier repair dressing according to claim 1, characterized in that: It is made of the following raw materials in percentage by weight: 0.5% high molecular weight hyaluronic acid, 1% medium molecular weight hyaluronic acid, 0.1% oligomeric sodium hyaluronate, 0.5% cationic guar gum, 1.2% small molecular weight recombinant humanized collagen, 1% L-lactic acid, 0.15% sodium ethylparaben, and the balance is pure water.

4. The skin barrier repair dressing according to any one of claims 1 to 3, characterized in that: The molecular weight of the high molecular weight hyaluronic acid is 1.4 to 1.6 million Da, the molecular weight of the medium molecular weight hyaluronic acid is 400,000 to 600,000 Da, the molecular weight of the oligomeric sodium hyaluronate is less than 10,000 Da, and the molecular weight of the small molecular weight recombinant humanized collagen is 500 to 2,000 Da.

5. The method for preparing the skin barrier repair dressing according to any one of claims 1 to 3, characterized in that: The method is: S1: Disperse the cationic guar gum evenly in cold pure water, let it stand and wait for it to swell naturally to form a transparent cationic guar gum gel solution for standby use; S2: Dissolve high molecular weight hyaluronic acid, medium molecular weight hyaluronic acid, oligomeric sodium hyaluronate, small molecular weight recombinant humanized collagen, and L-lactic acid in the remaining amount of pure water and stir until completely dissolved; S3: adding the cationic guar gum gel solution in S1 to the solution prepared in S2, adding sodium ethylparaben, mixing evenly and stirring thoroughly to homogenize; S4: The obtained gel solution is subjected to ultrasonic treatment to remove bubbles, and then packaged and sterilized by irradiation.

6. The method for preparing the skin barrier repair dressing according to claim 5, characterized in that: In the steps S2 and S3, the stirring speed is 3000-6000 rpm, the stirring temperature is 30-40° C., and the stirring time is 30-60 min.

7. The method for preparing the skin barrier repair dressing according to claim 5, characterized in that: The radiation source for irradiation sterilization in step S4 is cobalt-60, the dose is 25-40 kGy, and the sterilization time is 4-6 hours.

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