Human body transcranial ultrasonic irradiation method and device, electronic equipment and storage medium

Abstract

The invention provides a human body transcranial ultrasonic irradiation method and device, electronic equipment and a storage medium. A sagittal plane cross-sectional image and a cross section cross-sectional image of a target head are obtained; establishing a vertical coordinate system based on the sagittal plane cross-sectional image, and determining a target point coordinate of the island leaf on the vertical coordinate system; measuring the horizontal distance from the island leaf to the brain midline of the target head based on the cross-sectional image; mapping world coordinate points of the island leaves in a world coordinate system according to the target point coordinates and the horizontal distance; the ultrasonic transducer is controlled to irradiate the real position of the island leaf, accurate targeted irradiation can be achieved, the use cost of the low-intensity focused ultrasound technology is effectively reduced, and operation is simpler.

Description

Technical Field

[0001] The present invention relates to the field of non-invasive transcranial nerve regulation, and in particular to a method, device, electronic equipment and storage medium for transcranial ultrasound irradiation of a human body. Background Art

[0002] In recent years, low-intensity focused ultrasound has attracted widespread attention in the medical community as a cutting-edge neuromodulation method due to its significant advantages of non-invasiveness, high spatial resolution and high penetration depth. Low-intensity focused ultrasound can precisely act on specific brain areas without damaging surrounding tissues, thereby achieving regulation of neural activity.

[0003] At present, the mainstream irradiation method mainly relies on high-precision neuronavigation systems. These systems can track and locate the focal point of ultrasound in real time by combining imaging technologies such as magnetic resonance imaging (MRI) or computed tomography (CT), thereby achieving precise regulation of deep brain structures. However, high-precision neuronavigation systems are not only expensive, but also mainly used in complex surgical operations, which seriously limits the clinical application and development of low-intensity focused ultrasound technology.

[0004] In order to overcome this bottleneck, there is an urgent need to develop a feasible, cost-effective method to assist the use of low-intensity focused ultrasound in the brain. Summary of the invention

[0005] In view of the above problems, a method for human transcranial ultrasound stimulation positioning is proposed to overcome the above problems or at least partially solve the above problems, including: A method for transcranial ultrasound irradiation of a human body, the method comprising: Obtain sagittal and transverse tomographic images of the target head; A vertical coordinate system is established based on the sagittal tomographic image, and the target coordinates of the insula on the vertical coordinate system are determined; Based on the cross-sectional tomographic images, the horizontal distance from the insula to the midline of the target head was measured; According to the target coordinates and the horizontal distance, the world coordinate point of the insula is mapped in the world coordinate system. The world coordinate point of the insula is used to represent the real position of the insula in three-dimensional space; The ultrasound transducer is controlled to irradiate the actual position of the insula.

[0006] A method for transcranial ultrasound irradiation of a human body, the method comprising: Obtain sagittal and transverse tomographic images of the target head; Establishing a vertical coordinate system based on the sagittal plane tomographic image, and determining the target coordinates of the target regulation area on the vertical coordinate system; Based on the cross-sectional image, measuring the horizontal distance from the target regulated area to the midline of the target head brain; Mapping the world coordinate point of the target regulation area in a world coordinate system according to the target point coordinates and the horizontal distance, wherein the world coordinate point of the target regulation area is used to represent the real position of the target regulation area in three-dimensional space; Controlling the ultrasonic transducer to irradiate the actual position of the target regulation area; The step of establishing a vertical coordinate system based on the sagittal plane tomographic image and determining the target coordinates of the target control area on the vertical coordinate system includes: Based on the sagittal plane tomographic image, a vertical coordinate system is established with the nose tip as the origin and a line connecting the nose tip and the front edge of the forehead as the vertical axis; Construct the target regulatory region outline, select a number of discrete points within the target regulatory region outline, and calculate the average coordinates of the plurality of discrete points as the target point coordinates.

[0007] Preferably, a plurality of discrete points are taken within the outline of the target regulation region, and the average coordinates of the plurality of discrete points are calculated as the calculation formula for the target coordinates: Among them, (x i ,y i ) is the coordinate of the ith discrete point, and n is the total number of discrete points.

[0008] Preferably, the target regulatory area includes the insula.

[0009] Optionally, a vertical coordinate system is established based on the sagittal plane tomographic image, and the target coordinates of the insula on the vertical coordinate system are determined, including: Based on the sagittal tomographic image, a vertical coordinate system was established with the nose tip as the origin and the line between the nose tip and the front edge of the forehead as the vertical axis; Construct the insula contour, select several discrete points within the insula contour, and calculate the average coordinates of several discrete points as the target coordinates.

[0010] Optionally, a number of discrete points are taken within the contour of the insula, and the average coordinates of the discrete points are calculated as the calculation formula for the target coordinates:

[0011] Among them, (x i ,y i ) is the coordinate of the ith discrete point, and n is the total number of discrete points.

[0012] Optionally, according to the target coordinates and the horizontal distance, the world coordinate points of the insula are mapped in the world coordinate system, including: According to the preset conversion relationship, the horizontal coordinate in the target coordinate is converted into the X-axis coordinate of the insula in the world coordinate system, the vertical coordinate in the target coordinate is converted into the Y-axis coordinate of the insula in the world coordinate system, and the horizontal distance is converted into the Z-axis coordinate of the insula in the world coordinate system.

[0013] Optionally, controlling the ultrasound transducer to irradiate the actual position of the insula includes: The position of the ultrasonic transducer is adjusted along the XOY plane direction of the world coordinate system so that the focus of the ultrasonic transducer and the world coordinate point of the insula are on the same horizontal line, and the irradiation direction of the ultrasonic transducer is controlled to be perpendicular to the XOY plane of the world coordinate system; Adjust the position of the ultrasonic transducer along the Z-axis direction so that the focus of the ultrasonic transducer completely coincides with the world coordinate point of the insula; Fix and activate the ultrasound transducer to irradiate the true position of the insula.

[0014] Optionally, before fixing and starting the ultrasonic transducer to irradiate the actual position of the insula, the method further includes: Fill the space between the scalp and the ultrasound transducer with bubble-free coupling agent.

[0015] Optionally, the method of acquiring the sagittal tomographic image and the transverse tomographic image of the target head includes any one or more of the following: magnetic resonance imaging, computer tomography.

[0016] A human transcranial ultrasound irradiation auxiliary positioning device, the device comprising: An image acquisition module, used to acquire sagittal and transverse tomographic images of the target head; A target coordinate determination module is used to establish a vertical coordinate system based on the sagittal plane tomographic image and determine the target coordinates of the insula on the vertical coordinate system; A measurement module, used for measuring the horizontal distance from the insula to the midline of the target head based on the cross-sectional tomographic image; A mapping module, used to map the world coordinate point of the insula in the world coordinate system according to the target coordinates and the horizontal distance, and the world coordinate point of the insula is used to represent the real position of the insula in the three-dimensional space; The ultrasonic transducer control module is used to control the ultrasonic transducer to irradiate the actual position of the insula.

[0017] Optionally, the target coordinate determination module includes: The target coordinate calculation submodule is used to establish a vertical coordinate system based on the sagittal plane tomographic image, with the nose tip as the origin and the line connecting the nose tip and the front edge of the forehead as the vertical axis; and is used to construct the insular contour, take a number of discrete points within the insular contour, and calculate the average coordinates of the discrete points as the target coordinates.

[0018] An electronic device includes a processor, a memory, and a computer program stored in the memory and capable of running on the processor. When the computer program is executed by the processor, the steps of the above-mentioned human transcranial ultrasound irradiation method are implemented.

[0019] A computer-readable storage medium stores a computer program, which implements the steps of the above human transcranial ultrasound irradiation method when executed by a processor.

[0020] In an embodiment of the present invention, a sagittal tomographic image and a cross-sectional tomographic image of a target head are obtained; a vertical coordinate system is established based on the sagittal tomographic image to determine the target coordinates of the insula in the vertical coordinate system; based on the cross-sectional tomographic image, the horizontal distance from the insula to the midline of the target head brain is measured; according to the target coordinates and the horizontal distance, the world coordinate point of the insula is mapped in the world coordinate system; and the ultrasonic transducer is controlled to irradiate the actual position of the insula, thereby achieving precise targeted irradiation, effectively reducing the use cost of low-intensity focused ultrasound technology, and making the operation simpler. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solution of the present invention, the accompanying drawings required for use in the description of the present invention will be briefly introduced below. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative labor.

[0022] Figure 1 is a flowchart of the steps of a method for transcranial ultrasound irradiation of a human body provided by one embodiment of the present invention; Figure 2 This is an example of a head cross-sectional and sagittal tomographic image obtained by a subject undergoing a head MRI examination provided by an embodiment of the present invention; Figure 3 is a schematic diagram of coordinate axes for establishing a target sagittal plane tomographic image of the head of a subject in one embodiment of the present invention; Figure 4 It is a schematic diagram of measuring the coordinates of the insula according to the cross-sectional image and the sagittal tomographic image of the head according to one embodiment of the present invention; Figure 5 It is a schematic diagram of measuring the horizontal distance from the insula to the midline of the target head brain according to a head cross-sectional image according to an embodiment of the present invention; Figure 6 It is a schematic diagram of a human body transcranial ultrasound irradiation auxiliary positioning device provided by an embodiment of the present invention; Figure 7 An embodiment of the present invention is applicable to Figure 6 Schematic diagram of human head position; Figure 8, Fig. 9 The ultrasonic transducer of one embodiment of the present invention and Figure 6 Schematic diagram for use with. DETAILED DESCRIPTION

[0023] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below in conjunction with the accompanying drawings and specific embodiments. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] Reference Figures 1 to 9 , shows a flowchart of a method for transcranial ultrasound irradiation of a human body applicable to focused ultrasound provided by an embodiment of the present invention, which may specifically include the following steps: Step 101, obtaining a sagittal tomographic image and a transverse tomographic image of the target head; In some embodiments of the present invention, the method of acquiring the sagittal tomographic image and the transverse tomographic image of the target head includes any one or more of the following: magnetic resonance imaging (MRI), computed tomography (CT).

[0025] Magnetic Resonance Imaging (MRI) is a non-invasive medical imaging technique that uses strong magnetic fields and radio waves to generate detailed images of the internal structures of the human body. In practical applications, MRI can provide high-resolution soft tissue images, which helps doctors make accurate diagnoses.

[0026] Reference Figures 2 to 5 In some embodiments of the present invention, magnetic resonance imaging technology can be used to scan the target head to obtain sagittal and cross-sectional tomographic images of the target head, because it can provide high-resolution soft tissue images, which will help improve the accuracy of subsequent calculation of the true position of the insula, thereby further improving the accuracy of target irradiation. Those skilled in the art can also choose to use computed tomography (CT) or other medical imaging technologies to obtain sagittal and cross-sectional tomographic images of the target head according to actual conditions, and the present invention does not limit this.

[0027] In practical applications, MRI images are easily affected by various noises, such as random noise, artifacts, etc. Therefore, the present invention can also choose to use a pre-trained deep learning model (such as a convolutional neural network) to achieve denoising of MRI images. It is understandable that the pre-trained deep learning model can automatically learn complex denoising patterns, achieve rapid processing of MRI images of different situations, and effectively improve the acquisition efficiency of sagittal and cross-sectional tomographic images of the target head.

[0028] Step 102, establishing a vertical coordinate system based on the sagittal plane tomographic image, and determining the target coordinates of the insula (the insula is the target regulation area specifically selected in this embodiment, and in other embodiments, the target regulation area may also be a transcranial brain area, such as the prefrontal cortex, thalamus, temporal lobe, and deep brain tissue) on the vertical coordinate system; In some embodiments of the present invention, Figure 3 , Figure 4 As shown, a vertical coordinate system can be established based on the sagittal tomographic image, with the nose tip as the origin and the line connecting the nose tip and the front edge of the forehead as the vertical axis; wherein the target coordinates of the insula on the vertical coordinate system can be obtained as follows: The insular contour is constructed, a number of discrete points are taken within the insular contour, and the average coordinates of the plurality of discrete points are calculated as the target coordinates.

[0029] Specifically, the two-dimensional coordinates of several discrete points can be directly measured using a ruler or coordinate paper to obtain the two-dimensional coordinates of multiple discrete points; then the following formula is used to take the average value of the obtained two-dimensional coordinates of the multiple discrete points and record it as the target point coordinates:

[0030] Among them, (x i ,y i ) is the coordinate of the ith discrete point, and n is the total number of discrete points.

[0031] Assuming that only three discrete points are taken in this embodiment (for example only, in actual applications, the more discrete points there are, the higher the accuracy of the target coordinates), the coordinates of the first discrete point can be taken as (10, 20), the coordinates of the second discrete point can be taken as (12, 10), and the coordinates of the third discrete point can be taken as (14, 24). Substituting the coordinates of the above three discrete points into the above calculation formula, the coordinates of the target M can be obtained as (12, 18).

[0032] In some embodiments of the present invention, since the shape of the human insula is similar to a triangle, a triangle can be used as the outline of the insula, and then the perpendicular bisectors of the three sides of the triangle are respectively drawn, and the intersection point is taken as the target point, and then the target point coordinates are directly measured using a ruler or coordinate paper. Those skilled in the art can select the method for determining the target point coordinates according to actual conditions, and the present invention does not limit this.

[0033] Step 103, based on the cross-sectional image, measuring the horizontal distance from the insula to the midline of the target head brain; In some embodiments of the present invention, Figure 5 As shown, since the human brain is symmetrical in structure, after obtaining the cross-sectional image of the target head, the brain midline can be drawn, and then the position of the insula can be determined in the cross-sectional image, and the horizontal distance from the insula to the brain midline can be directly measured using a ruler.

[0034] Step 104, mapping the world coordinate point of the insula in a world coordinate system according to the target coordinates and the horizontal distance, wherein the world coordinate point of the insula is used to represent the real position of the insula in three-dimensional space; Specifically, according to a preset conversion relationship, the horizontal coordinate in the target coordinates can be converted into the X-axis coordinate of the insula in the world coordinate system, the vertical coordinate in the target coordinates can be converted into the Y-axis coordinate of the insula in the world coordinate system, and the horizontal distance can be converted into the Z-axis coordinate of the insula in the world coordinate system.

[0035] In practical applications, the sagittal tomographic image and the transverse tomographic image of the target head may be accompanied by a scale, and the scale is used to represent the relationship between the distance on the image and the distance in the real world.

[0036] For example, when the scale of the sagittal and transverse tomographic images of the target head is 1:2, the target coordinates are (12, 18), and the horizontal distance is 16, the three-dimensional coordinates of the insula in the world coordinate system can be calculated to be (24, 36, 32), thereby realizing the mapping of the world coordinate point of the insula in the world coordinate system.

[0037] Step 105, controlling the ultrasonic transducer to irradiate the actual position of the insula; In some embodiments of the present invention, irradiation of the actual position of the insula can be achieved by: Sub-step 1051, adjusting the position of the ultrasonic transducer along the XOY plane direction of the world coordinate system, so that the focus of the ultrasonic transducer and the world coordinate point of the insula are located on the same horizontal line, and controlling the irradiation direction of the ultrasonic transducer to be perpendicular to the XOY plane of the world coordinate system; It can be understood that in some embodiments of the present invention, the position of the ultrasonic transducer is adjusted along the XOY plane direction of the world coordinate system so that the focus of the ultrasonic transducer and the world coordinate point of the insula are on the same horizontal line, and the irradiation direction of the ultrasonic transducer is controlled to be perpendicular to the XOY plane of the world coordinate system. The horizontal position of the ultrasonic transducer can be preliminarily determined, that is, the ultrasonic transducer at this time can irradiate along the horizontal direction of the actual position of the insula, but the focus of the ultrasonic transducer does not completely coincide with the world coordinate point of the insula, that is, the ultrasonic transducer at this time cannot achieve precise irradiation of the insula.

[0038] Sub-step 1052, adjusting the position of the ultrasonic transducer along the Z-axis direction so that the focus of the ultrasonic transducer completely coincides with the world coordinate point of the insula; Based on the above problem, it is also necessary to adjust the horizontal position of the ultrasonic transducer along the Z-axis direction of the world coordinate system until the focus of the ultrasonic transducer completely coincides with the world coordinate point of the insula.

[0039] Sub-step 1053, fix and start the ultrasonic transducer to irradiate the actual position of the insula.

[0040] In an embodiment of the present invention, the ultrasonic transducer can be close to the scalp of the temporal lobe of the subject and maintain horizontal irradiation, that is, the irradiation direction of the ultrasonic transducer is ensured to be perpendicular to the sagittal plane of the subject's head, which can avoid the complex problem of angle adjustment when selecting other head acoustic windows.

[0041] In addition, it can be understood that the insula is an organ with a certain volume but a small size. When the disease occurs, the lesion may occur in a specific part of the insula. The embodiment of the present invention abstracts the insula as a point, which is conducive to more accurate targeted irradiation of the lesion site.

[0042] The embodiment of the present invention provides a method, device, electronic device and storage medium for transcranial ultrasound irradiation of human body. By acquiring sagittal tomographic images and transverse tomographic images of the target head; establishing a vertical coordinate system based on the sagittal tomographic images, determining the target coordinates of the insula in the vertical coordinate system; measuring the horizontal distance from the insula to the midline of the target head brain based on the transverse tomographic images; mapping the world coordinate point of the insula in the world coordinate system according to the target coordinates and the horizontal distance; and controlling the ultrasound transducer to irradiate the real position of the insula, accurate targeted irradiation can be achieved, and the use cost of low-intensity focused ultrasound technology is effectively reduced, and the operation is simpler.

[0043] like Figures 6 to 9 As shown, another method of transcranial ultrasound irradiation of human body of the present invention can also be implemented by the following steps: Step 201, set three mutually perpendicular fixed plates with scales, wherein the bottom fixed plate has a trapezoidal notch and the left fixed plate has a circular notch; establish a spatial coordinate system with the lower right corner of the front fixed plate as the origin, the side as the Y axis, and the bottom as the Z axis, such as Figure 6 shown.

[0044] Step 202, fix the subject's head posture so that the subject's nose tip is placed in front of the trapezoidal notch and the forehead is in contact with the front fixing plate, such as Figure 6 As shown, the trapezoidal notch is provided to ensure normal breathing of the subject.

[0045] Step 203, repeating the above steps 101 to 105, determining and fixing the position of the ultrasonic transducer, and recording the position of the nose tip of the subject at this time.

[0046] Step 204, a different subject is replaced, the nose tip of the subject is placed at the pre-recorded nose tip position, the forehead is attached to the front fixing plate, and the ultrasonic transducer is started to irradiate the insula of the subject.

[0047] It should be understood that, in actual applications, since the scaling ratio or scale of each target head sagittal tomographic image and cross-sectional tomographic image is consistent, and the head structure of each subject is basically the same, the world coordinates of the insular position of each subject after being mapped to the world coordinate system are also consistent. Therefore, in the embodiment of the present invention, different subjects only need to place the nose tip at the pre-recorded nose tip position, and ensure that the forehead fits the front fixing plate, and ensure that the subject's body is not tilted, so that the actual target area of ​​the head and the calculated target position coincide, and the ultrasonic transducer can be started to irradiate the insular lobe, which greatly improves the irradiation efficiency, and there is no need to repeatedly map the world coordinates of the subject's insular lobe and repeatedly adjust the position of the ultrasonic transducer.

[0048] In addition, before fixing and starting the ultrasonic transducer and irradiating the actual position of the insula, a bubble-free coupling agent can be filled between the subject's scalp and the ultrasonic transducer to ensure the conduction of sound energy and reduce the attenuation of sound energy.

[0049] The principle of the human transcranial ultrasound irradiation method in the embodiment of the present invention is based on the projection irradiation of the sagittal plane of the head. The acoustic window is selected in the temporal lobe area. It has a high positioning accuracy for deep brain tissues such as the temporal lobe, insula, and hippocampus, but is more limited in its application to the superficial layers of the frontal lobe and parietal lobe. During the application process, the skull's absorption and interference with sound energy can be evaluated, and an appropriate focal length can be set to ensure the safest and most effective stimulation of focused ultrasound.

[0050] The above-mentioned embodiment of the present invention provides a low-cost and simple method for brain targeted tissue positioning, which can solve the problem of targeting. This method can be applied not only to ultrasound regulation, but also to other non-invasive regulation methods. The principle is to project the intracranial target organ onto the scalp in the sagittal plane of the head, and then measure the vertical distance from the scalp to the target organ with the help of the head MRI image. In this way, targeted stimulation can be achieved by adjusting the focus position of the focused ultrasound, which is low-cost and easy to operate.

[0051] It should be noted that, for the sake of simplicity, the method embodiments are described as a series of action combinations, but those skilled in the art should be aware that the embodiments of the present invention are not limited by the order of the actions described, because according to the embodiments of the present invention, certain steps can be performed in other orders or simultaneously. Secondly, those skilled in the art should also be aware that the embodiments described in the specification are all preferred embodiments, and the actions involved are not necessarily required by the embodiments of the present invention.

[0052] A schematic diagram of a module of a human transcranial ultrasound irradiation auxiliary positioning device provided by an embodiment of the present invention may specifically include the following modules: An image acquisition module, used to acquire sagittal and transverse tomographic images of the target head; A target coordinate determination module is used to establish a vertical coordinate system based on the sagittal plane tomographic image and determine the target coordinates of the insula on the vertical coordinate system; A measurement module, used for measuring the horizontal distance from the insula to the midline of the target head based on the cross-sectional tomographic image; A mapping module, used to map the world coordinate point of the insula in the world coordinate system according to the target coordinates and the horizontal distance, and the world coordinate point of the insula is used to represent the real position of the insula in the three-dimensional space; The ultrasonic transducer control module is used to control the ultrasonic transducer to irradiate the actual position of the insula.

[0053] Optionally, the target coordinate determination module includes: The target coordinate calculation submodule is used to establish a vertical coordinate system based on the sagittal plane tomographic image, with the nose tip as the origin and the line connecting the nose tip and the front edge of the forehead as the vertical axis; construct the insular contour, take a number of discrete points within the insular contour, and calculate the average coordinates of the discrete points as the target coordinates.

[0054] Optionally, a number of discrete points are taken within the contour of the insula, and the average coordinates of the discrete points are calculated as the calculation formula for the target coordinates:

[0055] Among them, (x i ,y i) is the coordinate of the ith discrete point, and n is the total number of discrete points.

[0056] Optionally, the mapping module comprises: The coordinate conversion submodule is used to convert the horizontal coordinate in the target coordinate into the X-axis coordinate of the insula in the world coordinate system, convert the vertical coordinate in the target coordinate into the Y-axis coordinate of the insula in the world coordinate system, and convert the horizontal distance into the Z-axis coordinate of the insula in the world coordinate system according to the preset conversion relationship.

[0057] Optionally, the ultrasonic transducer control module comprises: The ultrasonic transducer adjustment submodule is used to adjust the position of the ultrasonic transducer along the XOY plane direction of the world coordinate system so that the focus of the ultrasonic transducer and the world coordinate point of the insula are on the same horizontal line, and control the irradiation direction of the ultrasonic transducer to be perpendicular to the XOY plane of the world coordinate system; adjust the position of the ultrasonic transducer along the Z-axis direction so that the focus of the ultrasonic transducer completely coincides with the world coordinate point of the insula; fix and start the ultrasonic transducer to irradiate the actual position of the insula.

[0058] Optionally, it also includes: The coupling agent filling module is used to fill the space between the scalp and the ultrasound transducer with bubble-free coupling agent.

[0059] Optionally, the method of acquiring the sagittal tomographic image and the transverse tomographic image of the target head includes any one or more of the following: magnetic resonance imaging, computer tomography.

[0060] An embodiment of the present invention further provides an electronic device, which may include a processor, a memory, and a computer program stored in the memory and capable of running on the processor. When the computer program is executed by the processor, the above-mentioned human transcranial ultrasound irradiation method is implemented.

[0061] An embodiment of the present invention further provides a computer-readable storage medium, on which a computer program is stored. When the computer program is executed by a processor, the above-mentioned human transcranial ultrasound irradiation method is implemented.

[0062] As for the device embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and the relevant parts can be referred to the partial description of the method embodiment.

[0063] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0064] Those skilled in the art will appreciate that the embodiments of the present invention may be provided as methods, devices, or computer program products. Therefore, the embodiments of the present invention may take the form of a complete hardware embodiment, a complete software embodiment, or an embodiment combining software and hardware. Moreover, the embodiments of the present invention may take the form of a computer program product implemented on one or more computer-usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) containing computer-usable program codes.

[0065] The above is a detailed introduction to a human transcranial ultrasound irradiation method, device, electronic device and storage medium. Specific examples are used in this article to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea; at the same time, for general technical personnel in this field, according to the idea of ​​the present invention, there will be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as a limitation on the present invention.

Claims

1. A method for transcranial ultrasound irradiation of a human body, characterized in that: The method comprises: Obtain sagittal and transverse tomographic images of the target head; Establishing a vertical coordinate system based on the sagittal plane tomographic image, and determining the target coordinates of the target regulation area on the vertical coordinate system; Based on the cross-sectional image, measuring the horizontal distance from the target regulated area to the midline of the target head brain; Mapping the world coordinate point of the target regulation area in a world coordinate system according to the target point coordinates and the horizontal distance, wherein the world coordinate point of the target regulation area is used to represent the real position of the target regulation area in three-dimensional space; Controlling the ultrasonic transducer to irradiate the actual position of the target regulation area; The step of establishing a vertical coordinate system based on the sagittal plane tomographic image and determining the target coordinates of the target control area on the vertical coordinate system includes: Based on the sagittal plane tomographic image, a vertical coordinate system is established with the nose tip as the origin and a line connecting the nose tip and the front edge of the forehead as the vertical axis; Construct the target regulatory region outline, select a number of discrete points within the target regulatory region outline, and calculate the average coordinates of the plurality of discrete points as the target point coordinates.

2. The method according to claim 1, characterized in that A number of discrete points are taken within the outline of the target regulation area, and the average coordinates of the discrete points are calculated as the calculation formula for the target coordinates: ； Among them, (x i ,y i ) is the coordinate of the ith discrete point, and n is the total number of discrete points.

3. The method according to claim 1 or 2, characterized in that: The target regulatory area includes the insula.

4. The method according to claim 3, characterized in that Mapping the world coordinate point of the insula in a world coordinate system according to the target coordinates and the horizontal distance includes: According to the preset conversion relationship, the horizontal coordinate in the target coordinate is converted into the X-axis coordinate of the insula in the world coordinate system, the vertical coordinate in the target coordinate is converted into the Y-axis coordinate of the insula in the world coordinate system, and the horizontal distance is converted into the Z-axis coordinate of the insula in the world coordinate system.

5. The method according to claim 4, characterized in that The controlling the ultrasonic transducer to irradiate the real position of the insula includes: Adjusting the position of the ultrasonic transducer along the XOY plane direction of the world coordinate system so that the focus of the ultrasonic transducer and the world coordinate point of the insula are located on the same horizontal line, and controlling the irradiation direction of the ultrasonic transducer to be perpendicular to the XOY plane of the world coordinate system; Adjusting the position of the ultrasonic transducer along the Z-axis direction so that the focus of the ultrasonic transducer completely coincides with the world coordinate point of the insula; The ultrasonic transducer is fixed and started to irradiate the actual position of the insula.

6. The method according to claim 5, characterized in that Before fixing and starting the ultrasonic transducer to irradiate the real position of the insula, the method further includes: A bubble-free coupling agent is filled between the scalp and the ultrasound transducer.

7. The method according to claim 6, characterized in that: The method of obtaining the sagittal tomographic image and the transverse tomographic image of the target head includes any one or more of the following: magnetic resonance imaging, computer tomography.

8. A human transcranial ultrasound irradiation auxiliary positioning device, characterized in that: The device comprises: An image acquisition module, used to acquire sagittal and transverse tomographic images of the target head; A target coordinate determination module, used to establish a vertical coordinate system based on the sagittal plane tomographic image, and determine the target coordinates of the insula on the vertical coordinate system; A measuring module, used for measuring the horizontal distance from the insula to the midline of the target head brain based on the cross-sectional image; A mapping module, used for mapping the world coordinate point of the insula in a world coordinate system according to the target point coordinates and the horizontal distance, wherein the world coordinate point of the insula is used to represent the real position of the insula in three-dimensional space; An ultrasonic transducer control module, used for controlling the ultrasonic transducer to irradiate the actual position of the insula; The target point coordinate determination module comprises: The target coordinate calculation submodule is used to establish a vertical coordinate system based on the sagittal plane tomographic image, with the nose tip as the origin and the line connecting the nose tip and the front edge of the forehead as the vertical axis; and is used to construct the insular contour, take a number of discrete points within the insular contour, and calculate the average coordinates of the discrete points as the target coordinates.

9. An electronic device, characterized in that: The method comprises a processor, a memory and a computer program stored in the memory and capable of running on the processor, wherein when the computer program is executed by the processor, the steps of the method for transcranial ultrasound irradiation of the human body as claimed in any one of claims 1 to 7 are implemented.

10. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the steps of the human transcranial ultrasound irradiation method according to any one of claims 1 to 7 are implemented.

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