Distillation and purification device based on medical intermediate production and implementation method
By introducing stirring parts and cooling parts into the distillation equipment of pharmaceutical intermediates, efficient purification and purity improvement of pharmaceutical intermediates are achieved, and the problem of scale accumulation in the inner wall of distillation equipment is solved, which extends the equipment life and simplifies the cleaning process.
Patent Information
- Application Number
- CN202411327782.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-23
- Publication Date
- 2024-12-27
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing pharmaceutical intermediate distillation equipment is prone to accumulation of scale on the inner wall after long-term use, which affects heat transfer performance and service life, and is inconvenient to manually clean.
A distillation purification device including a distillation chamber, a collection box, agitator and a cooling member are designed to uniformly stir and cool the steam through the stirring member to achieve efficient purification of pharmaceutical intermediates, and reduce scale through agitator blades and cleaning brushes. Body adhesion to improve equipment cleaning efficiency.
It improves the purity and purification effect of pharmaceutical intermediates, extends the service life of the equipment, reduces the workload of manual cleaning, and enhances the cleanliness and heat transfer performance of the equipment.
Smart Images
Figure CN119185983A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of concentrated preparation of pharmaceutical intermediates, in particular to a distillation purification device and an implementation method based on the production of pharmaceutical intermediates. Background Art
[0002] Pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the process of drug synthesis. This kind of chemical product does not require a drug production license and can be produced in ordinary chemical plants. As long as it reaches a certain level, it can be used in the synthesis of drugs.
[0003] The production of Chinese medicine intermediates in the prior art is usually extracted from chemical raw materials and animals and plants. The extraction method usually uses distillation. The existing distillation equipment has poor effect and the purity needs to be improved. After long-term use, a large amount of scale is easily accumulated on the inner wall of the distillation kettle, which in turn affects the heat transfer performance of the distillation kettle. The presence of scale will also cause corrosion to the inner wall of the kettle, affecting the service life of the distillation kettle. Manual cleaning increases the workload of the staff and brings inconvenience to the staff. Summary of the invention
[0004] In view of this, an object of the present invention is to provide a distillation and purification device based on the production of pharmaceutical intermediates, which can realize the preparation of pharmaceutical intermediates and avoid corrosion of the inner wall of the distillation chamber.
[0005] The present invention is implemented by the following method: a distillation and purification device based on the production of pharmaceutical intermediates, including a support frame, a distillation bin is arranged on the left end of the support frame, a collecting box is arranged on the right end of the support frame, the distillation bin and the collecting box are connected via a steam outlet pipe, the steam outlet end of the steam outlet pipe is connected to the collecting box via a flange, a cooling part is arranged on the steam outlet pipe, a stirring part is arranged in the distillation bin, a heating wire is arranged in the wall of the distillation bin, a pressure relief valve is connected to the upper end of the left side surface of the distillation bin, a feed pipe is connected to the left end of the upper surface of the distillation bin, a solenoid valve is arranged on the steam outlet end of the steam outlet pipe, and a discharge pipe is connected to the left end of the lower surface of the distillation bin.
[0006] Furthermore, the cooling element includes a cooling box body, the cooling box body is sleeved on the steam outlet pipe, an annular cooling pipe is arranged in the cooling box body, the water inlet end of the annular cooling pipe is connected to the water inlet pipe, and the water outlet end of the annular cooling pipe is connected to the water outlet pipe.
[0007] Furthermore, the stirring member includes a driving motor, which is arranged in the middle of the bottom surface of the distillation chamber, and the output end of the driving motor is connected to a rotating shaft, and a plurality of clamps are equidistantly sleeved on the rotating shaft, and stirring blades are connected to the left and right ends of the clamps.
[0008] Furthermore, a cleaning brush is provided at the end of the stirring blade, and the cleaning brush is arranged perpendicular to the stirring blade.
[0009] Furthermore, a filter plate is pulled out from the upper front end of the collection box, the filter plate is arranged in the collection box, a scale is arranged on the front of the collection box, and movable wheels with brakes are arranged around the lower surface of the collection box.
[0010] Another object of the present invention is to provide a method for preparing pharmaceutical intermediates by allowing users to operate distillation equipment conveniently.
[0011] A method for implementing a distillation purification device based on the production of pharmaceutical intermediates, comprising the following steps:
[0012] Step S1, delivering the pharmaceutical intermediate raw material to the distillation chamber through a feed pipe, and heating and distilling the distillation chamber through the action of a heating wire;
[0013] Step S2, through the action of the stirring element, the pharmaceutical intermediate raw material can be uniformly stirred and distilled, shortening the concentration time of the pharmaceutical intermediate. After heating, the pharmaceutical intermediate raw material is heated to become a gas, and the steam is discharged through the steam outlet pipe; Step S3, the steam in the steam outlet pipe is cooled by the cooling element, so that the concentrated pharmaceutical intermediate raw material is converted into a liquid and transported to the collection box, thereby realizing the preparation of the pharmaceutical intermediate and facilitating the collection and transportation after concentration.
[0014] The beneficial effects of the present invention are as follows: a distillation chamber, a collecting box, a stirring element and a cooling element are added to the device of the present invention; the pharmaceutical intermediate raw material is distilled, and the gaseous pharmaceutical intermediate after distillation enters the collecting box, thereby obtaining a pharmaceutical intermediate with higher purity, realizing the preparation and purification of the pharmaceutical intermediate, realizing the extraction and concentration of the pharmaceutical intermediate, and then through the action of the stirring element, the pharmaceutical intermediate can be uniformly distilled, and the pharmaceutical intermediate raw material can be uniformly stirred through the stirring element, which is convenient for uniform heating, effectively solving the problem that a large amount of scale is easily accumulated on the inner wall of the distillation equipment, effectively increasing the cleaning area of the stirring component, making it difficult for scale to adhere to the inner cavity of the distillation equipment, and having a good purification effect, the present invention is worthy of vigorous promotion. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] Figure 1 It is a schematic diagram of the structure of the present invention.
[0016] Figure 2 It is a schematic structural diagram of the stirring element.
[0017] Figure 3 It is the front view of the collection box.
[0018] Figure 4It is a schematic diagram of the process flow of the present invention. DETAILED DESCRIPTION
[0019] The present invention will be further described below in conjunction with the accompanying drawings.
[0020] See also Figures 1 to 3 As shown, the present invention provides an embodiment: a distillation and purification device based on the production of pharmaceutical intermediates, comprising a support frame 1, a distillation bin 2 is arranged on the left end of the support frame 1, a collecting box 3 is arranged on the right end of the support frame 1, the distillation bin 2 and the collecting box 3 are connected via a steam outlet pipe 4, the steam outlet end of the steam outlet pipe 4 is connected to the collecting box 3 via a flange 41, a cooling part 5 is arranged on the steam outlet pipe 4, a stirring part 6 is arranged in the distillation bin 2, a heating wire 21 is arranged in the wall of the distillation bin 2, a pressure relief valve 22 is connected to the upper end of the left side surface of the distillation bin 2, a feed pipe 23 is connected to the left end of the upper surface of the distillation bin 2, a solenoid valve 42 is arranged on the steam outlet end of the steam outlet pipe 4, and a discharge pipe 24 is connected to the left end of the lower surface of the distillation bin 2. The distillation chamber 2 enables the distillation of pharmaceutical intermediates, the heating wire 21 performs heating distillation, the stirring element 6 enables uniform distillation of pharmaceutical intermediates, the stirring element enables uniform stirring of pharmaceutical intermediate raw materials, and uniform heating is achieved. The heated steam is transported through the steam outlet pipe 4, and the steam is converted into liquid through the cooling effect of the cooling element 5, which is collected through the collecting box 3 to obtain a pharmaceutical intermediate with higher purity.
[0021] Please continue reading Figure 1 As shown, in one embodiment of the present invention, the cooling member 5 includes a cooling box 51, the cooling box 51 is sleeved on the steam outlet pipe 4, an annular cooling pipe 52 is arranged in the cooling box 51, the water inlet end of the annular cooling pipe 52 is connected to a water inlet pipe 53, and the water outlet end of the annular cooling pipe 52 is connected to a water outlet pipe 54. The steam can be converted into liquid through the action of the annular cooling pipe 52, thereby realizing the purification and collection of the pharmaceutical intermediate.
[0022] Please continue reading Figure 1 As shown, in one embodiment of the present invention, the stirring member 6 includes a driving motor (not shown), which is arranged in the middle of the inner bottom surface of the distillation chamber 2, and the output end of the driving motor 61 is connected to a rotating shaft 62, and a plurality of hoops 63 are sleeved on the rotating shaft 62 at equal distances, and stirring blades 64 are connected to the left and right ends of the hoops 63. The rotating shaft 62 is driven by the driving motor to rotate, so that the stirring blades 64 can be rotated, and the pharmaceutical intermediate raw materials can be uniformly stirred, which is convenient for achieving uniform heating.
[0023] Please continue reading Figure 1 and Figure 2As shown, in one embodiment of the present invention, a cleaning brush 65 is provided at the end of the stirring blade 64, and the cleaning brush 65 is arranged perpendicular to the stirring blade 64. The cleaning brush 65 can clean the inner wall of the distillation chamber 2 to prevent residue from adhering to the inner wall of the distillation chamber 2.
[0024] Please continue reading Figure 1 and Figure 3 As shown, in one embodiment of the present invention, a filter plate 31 is provided at the upper end of the front of the collection box 3, the filter plate 31 is arranged in the collection box 3, a scale 32 is arranged on the front of the collection box 3, and moving wheels 33 with brakes are arranged around the lower surface of the collection box 3. The filter plate 31 can be used to filter and purify the pharmaceutical intermediates, and the moving wheels 33 can be used to move the collection box 3.
[0025] See also Figure 4 As shown, a method for implementing a distillation purification device based on the production of pharmaceutical intermediates includes the following steps:
[0026] Step S1, delivering the pharmaceutical intermediate raw material to the distillation chamber through a feed pipe, and heating and distilling the distillation chamber through the action of a heating wire;
[0027] Step S2, through the action of the stirring element, the pharmaceutical intermediate raw material can be uniformly stirred and distilled, shortening the concentration time of the pharmaceutical intermediate. After heating, the pharmaceutical intermediate raw material is heated to become a gas, and the steam is discharged through the steam outlet pipe; Step S3, the steam in the steam outlet pipe is cooled by the cooling element, so that the concentrated pharmaceutical intermediate raw material is converted into a liquid and transported to the collection box, thereby realizing the preparation of the pharmaceutical intermediate and facilitating the collection and transportation after concentration.
[0028] The above description is only a preferred embodiment of the present invention. All equivalent changes and modifications made according to the scope of the patent application of the present invention should fall within the scope of the present invention.
Claims
1. A distillation and purification device for the production of pharmaceutical intermediates, characterized in that: It includes a support frame, a distillation bin is arranged on the left end of the support frame, a collecting box is arranged on the right end of the support frame, the distillation bin and the collecting box are connected via a steam outlet pipe, the steam outlet end of the steam outlet pipe is connected to the collecting box via a flange, a cooling element is arranged on the steam outlet pipe, a stirring element is arranged in the distillation bin, a heating wire is arranged in the wall of the distillation bin, a pressure relief valve is connected to the upper end of the left side surface of the distillation bin, a feed pipe is connected to the left end of the upper surface of the distillation bin, a solenoid valve is arranged on the steam outlet end of the steam outlet pipe, and a discharge pipe is connected to the left end of the lower surface of the distillation bin.
2. A distillation and purification device based on the production of pharmaceutical intermediates according to claim 1, characterized in that: The cooling element comprises a cooling box body, the cooling box body is sleeved on the steam outlet pipe, an annular cooling pipe is arranged in the cooling box body, the water inlet end of the annular cooling pipe is connected to the water inlet pipe, and the water outlet end of the annular cooling pipe is connected to the water outlet pipe.
3. A distillation and purification device based on the production of pharmaceutical intermediates according to claim 1, characterized in that: The stirring member comprises a driving motor, which is arranged in the middle of the bottom surface of the distillation chamber. The output end of the driving motor is connected to a rotating shaft, and a plurality of clamps are equidistantly sleeved on the rotating shaft. Both left and right ends of the clamps are connected to stirring blades.
4. A distillation and purification device based on the production of pharmaceutical intermediates according to claim 3, characterized in that: A cleaning brush is arranged at the end of the stirring blade, and the cleaning brush is arranged perpendicular to the stirring blade.
5. A distillation and purification device for producing pharmaceutical intermediates according to claim 1, characterized in that: A filter plate is provided on the upper front end of the collecting box body, and the filter plate is arranged in the collecting box body. A scale is arranged on the front side of the collecting box body, and movable wheels with brakes are arranged around the lower surface of the collecting box body.
6. A method for implementing the distillation purification device based on the production of pharmaceutical intermediates as claimed in claim 1, characterized in that: The following steps are involved: Step S1, delivering the pharmaceutical intermediate raw material to the distillation chamber through a feed pipe, and heating and distilling the distillation chamber through the action of a heating wire; Step S2, through the action of the stirring element, the pharmaceutical intermediate raw material can be uniformly stirred and distilled, shortening the concentration time of the pharmaceutical intermediate. After heating, the pharmaceutical intermediate raw material is heated to become a gas, and the steam is discharged through the steam outlet pipe; Step S3, cooling the steam in the steam outlet pipe by a cooling element, thereby converting the concentrated pharmaceutical intermediate raw material into a liquid and transporting it to a collection box, thereby realizing the preparation of the pharmaceutical intermediate and facilitating the collection and transportation after concentration.