Pure traditional Chinese medicine spray for treating pain in neck, shoulders, waist and legs and preparation method of pure traditional Chinese medicine spray

Abstract

The invention discloses a pure traditional Chinese medicine spray for treating pain in neck, shoulders, waist and legs and a preparation method of the pure traditional Chinese medicine spray. The spray is composed of a main medicinal component group, a blood-activating and stasis-removing component group, an aromatic component group and a solvent group, the main medicinal components comprise radix aconiti preparata, radix aconiti kusnezoffii preparata, rhizoma arisaematis preparata, semen strychni preparata and lumbricus, the blood-activating and stasis-removing component comprises flos carthami, stephania tetrandra and cortex acanthopanacis, the aromatic component is borneol, menthol and camphor, and the solvent is 75% alcohol. The spray is prepared through accurate proportioning and combining the steps of soaking, heating extraction, filtering, mixing and the like, and has the advantages of quick effect taking, high permeability and convenience in use. The spray can effectively relieve pain caused by pain in neck, shoulders, waist and legs, is suitable for long-term use and has no obvious side effect.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine sprays, in particular to a pure traditional Chinese medicine spray for treating neck, shoulder, waist and leg pains and a preparation method thereof. Background Art

[0002] Neck, shoulder, waist and leg pain is a very common chronic pain symptom worldwide, especially among people who work at a desk for a long time, sit for a long time or engage in physical labor. According to research, nearly 30% of adults will experience neck, shoulder, waist and leg pain to varying degrees at some stage in their lives, and the incidence rate increases significantly with age. Such diseases are usually accompanied by muscle stiffness, joint pain, limited mobility and other problems, which not only affect work efficiency, but also have a negative impact on quality of life.

[0003] Traditional treatments include oral nonsteroidal anti-inflammatory drugs (NSAIDs) and topical analgesics such as ointments, patches and massage oils. However, oral medications have a greater risk of side effects, especially when used for a long time, which may cause gastrointestinal discomfort, liver and kidney damage, etc., limiting their widespread use. In addition, oral medications are not effective in relieving local pain because the drugs need to circulate throughout the body to reach the lesion, which leads to dispersion and reduction of drug efficacy.

[0004] Although topical medications can act directly on the painful area, common plasters and patches have problems such as poor permeability and inconvenience in use. Patches often take a long time to work, and their transdermal absorption effect is not ideal, which makes it difficult for the active ingredients of the drug to penetrate into the deep tissue of the lesion. In addition, patches are easy to fall off during exercise, which limits their use scenarios. Although traditional ointments can promote absorption through massage, the actual effect is difficult to guarantee due to differences in massage intensity, time and technique.

[0005] There are also a variety of spray products on the market. These products are sprayed directly on the skin surface through aerosols or liquids, which can overcome the limitations of patches and ointments to a certain extent. However, most sprays are mainly composed of Western medicine ingredients. Although they can take effect quickly, long-term use may cause skin allergies and irritation, and patients are prone to drug resistance to these drugs. In addition, the existing Chinese medicine spray formulas are relatively simple, lack the synergistic effect of compound Chinese medicinal materials, have limited efficacy, and cannot meet the needs of effective treatment of long-term pain.

[0006] Therefore, developing a spray based on a traditional Chinese medicine compound that has good permeability, lasting efficacy, rapid onset and ease of use has become an urgent need to improve existing treatments for neck, shoulder, waist and leg pain. Summary of the invention

[0007] The purpose of the present invention is to provide a pure Chinese medicine spray for treating neck, shoulder, waist and leg pain and a preparation method thereof, which has the advantages of rapid onset of action, strong permeability, convenient use and high safety, and solves the problems of poor efficacy, inconvenience in use and large side effects of existing treatment methods.

[0008] To achieve the above object, the present invention provides the following technical solution: a pure Chinese medicine spray for treating neck, shoulder, waist and leg pain, the Chinese medicine spray is composed of the following components:

[0009] The main active ingredient group: processed Chuanwu, processed Caowu, processed Tiannanxing, processed Strychnos nux vomica, and earthworm;

[0010] Blood circulation and stasis-removing ingredient group: safflower, tetrandra chinensis, acanthopanax cortex, vinegar frankincense, scalded drynaria, vinegar myrrh, and dragon's blood;

[0011] Aromatic ingredient group: borneol, menthol, camphor;

[0012] Solvent group: 75% alcohol.

[0013] Preferably, the proportions of the components are as follows: Main medicinal ingredient group:

[0014] Processed Chuanwu: 100-300 portions;

[0015] Processed Radix Aconiti Kusnezoffii: 100-300 portions;

[0016] Processed Arisaema: 100-300 portions;

[0017] Prepared Strychnos nux vomica: 100-300 portions;

[0018] Earthworm: 100-300 servings;

[0019] Blood circulation and blood stasis removing ingredient group:

[0020] Safflower: 50-150 parts;

[0021] Radix Stephaniae Tetrandrae: 50-150 parts;

[0022] Acanthopanax Cortex: 50-150 portions;

[0023] Vinegar frankincense: 50-150 parts;

[0024] Scalded Drynaria fortunei: 50-150 servings;

[0025] Vinegar myrrh: 50-150 parts;

[0026] Dragon's blood: 50-100 portions;

[0027] Fragrance ingredient group:

[0028] Borneol: 30-60 parts;

[0029] Menthol: 30-60 parts;

[0030] Camphor: 60-120 parts;

[0031] Solvent Group:

[0032] 75% alcohol: 6000-12000 parts.

[0033] Preferably, the specific ratio range of the Chinese medicine spray is

[0034] Main active ingredient group:

[0035] The proportion of processed Chuanwu, processed Caowu, processed Tiannanxing, processed Strychnos nux vomica and earthworm is 150-250 parts;

[0036] Blood circulation and blood stasis removing ingredient group:

[0037] The proportion of safflower, fangji, acanthopanax bark, vinegar frankincense, scalded drynaria, vinegar myrrh is 75-125 parts;

[0038] The ratio of Dragon's Blood is 60-80 parts;

[0039] Fragrance ingredient group:

[0040] The ratio of borneol and menthol is 40-50 parts;

[0041] The proportion range of camphor is: 80-100 parts;

[0042] Solvent Group:

[0043] The mixing ratio range of 75% alcohol is: 9000-10000 parts.

[0044] Preferably, the powder fineness of the main medicinal ingredient group is in the range of 80-120 mesh, the viscosity of the liquid medicine after the blood circulation and blood stasis removal component group is dissolved is 10-15mPa·s, the volatilization rate of borneol and menthol in the aromatic component group is 10-20 minutes, the evaporation rate of 75% alcohol in the solvent group is 20-30 minutes, the atomized particle size of the spray is in the range of 10-50 microns, the pH value is in the range of 5.5-7.0, and the liquid medicine density is 0.90-1.10g / cm 3 , the surface tension is 30-50mN / m.

[0045] A method for preparing a pure Chinese medicine spray for treating neck, shoulder, waist and leg pain comprises the following steps:

[0046] S1. Raw material preparation:

[0047] S1.1. Weigh processed Chuanwu, processed Caowu, processed Arisaema, processed Strychnos nux vomica, earthworm, safflower, Tetrandrakia tetrandra, vinegar frankincense, vinegar myrrh, scalded Drynariae Rhizoma, Acanthopanax acanthopanax Cortex according to the formula ratio;

[0048] S1.2. Check the quality of each Chinese herbal medicine to ensure that there are no impurities or mildew;

[0049] S1.3, crush all medicinal materials to 80-120 mesh fineness to facilitate the extraction of active ingredients;

[0050] S2. Soaking:

[0051] S2.1. Place the crushed medicinal materials into a stainless steel soaking container;

[0052] S2.2, add 75% alcohol, the ratio of alcohol to medicinal materials is 10:1;

[0053] S2.3. Ensure that the medicinal materials are completely submerged and seal the container;

[0054] S2.4. Soak for 30 days, stirring once a day to ensure that the medicinal materials are fully in contact with the alcohol;

[0055] S3, heating extraction:

[0056] S3.1, transferring the soaked liquid to the cooking device;

[0057] S3.2, heat to 85-95°C and maintain for 1-2 hours;

[0058] S3.3. Stir continuously during the process to ensure that the liquid medicine is heated evenly;

[0059] S3.4. After completion, cool the solution to room temperature;

[0060] S4. Filtering:

[0061] S4.1. Filter the extracted liquid medicine using a 200-mesh filter to remove the medicine residue;

[0062] S4.2. If further clarification is required, perform secondary filtration to ensure that the liquid medicine is clear and free of impurities;

[0063] S4.3. Collect the filtered liquid medicine in a clean container for later use;

[0064] S5, Mixed:

[0065] S5.1. Add dragon's blood, borneol, menthol and camphor into the clarified liquid medicine in proportion;

[0066] S5.2. Stir evenly to ensure that all ingredients are fully dissolved;

[0067] S5.3, stirring duration is 30 minutes to ensure uniform distribution of ingredients;

[0068] S6. Settling:

[0069] S6.1. Place the mixed solution in a clean container and let it stand for 24 hours;

[0070] S6.2. Keep the temperature at room temperature and avoid direct sunlight to prevent the liquid from volatilizing or deteriorating;

[0071] S6.3. After standing, take the supernatant and discard the precipitate;

[0072] S7, Packaging:

[0073] S7.1. Dispense the supernatant into sterile spray bottles to ensure aseptic operation;

[0074] S7.2. Each bottle should be filled to the specified capacity to avoid wasting of liquid medicine;

[0075] S7.3. Seal after packaging to ensure good sealing.

[0076] Preferably, in the step S1, the pulverization fineness of all medicinal materials is controlled at 80-120 meshes, and a humidity test is performed immediately after the pulverization is completed to ensure that the humidity is not higher than 8%; if the humidity of the medicinal materials exceeds the standard, they are dried at a temperature of 30-40°C, and the drying time is controlled at 4-6 hours until the humidity reaches the standard before they can be stored.

[0077] Preferably, in the step S2, a stirring device is used to continuously stir at a low speed during the soaking process, each stirring lasts for 15 minutes, and the stirring interval is 2 hours; an alcohol concentration test is performed once on the 15th day and the 30th day of soaking to ensure that the 75% alcohol concentration is stable; if there is any loss, alcohol is supplemented to the required concentration to prevent insufficient extraction of the active ingredients.

[0078] Preferably, in the step S3, a constant temperature heating device is used for heating extraction, and the temperature is maintained within the range of 90°C±2°C. The volatility of the solution needs to be monitored during the heating process and is controlled within 1% of the total liquid volume. After the extraction is completed, the medicinal solution is rapidly cooled in a vacuum environment to below 25°C, and is immediately sealed and stored.

[0079] Preferably, in the S4 step, the filtration process is divided into two steps: the first step is to filter out coarse impurities through a 200-mesh primary filter screen, and the second step is to perform deep filtration through a 0.45-micron precision filter membrane to ensure the clarity of the medicinal solution; the filtered medicinal solution is stored in a sterile environment and subsequently processed within 24 hours.

[0080] Compared with the prior art, the present invention has the following beneficial effects:

[0081] 1. The present invention achieves the effects of comprehensive conditioning and rapid pain relief by setting up a Chinese medicine compound ingredient group; compared with the existing single-ingredient spray, the compound Chinese medicine of the present invention can play a synergistic role and improve the therapeutic effect, especially in the treatment of deep lesions of neck, shoulder, waist and leg pain.

[0082] 2. By using 75% alcohol as a solvent, the transdermal absorption of Chinese medicine ingredients is effectively enhanced, achieving the advantages of rapid penetration into the lesion site and rapid onset of effect, solving the problems of poor permeability and short-lasting efficacy of traditional topical drugs.

[0083] 3. The spray form makes it more convenient to use. Compared with patches and ointments, the present invention does not require massage or long-term application, which is convenient for patients to use by themselves in daily life and work, while reducing skin irritation and local discomfort.

[0084] 4. The preparation method of the present invention is scientific and rigorous. Through the steps of soaking, heating extraction, filtering and the like, the stability and uniformity of the Chinese medicine components are ensured, the loss of efficacy of the Chinese medicine components due to improper processing is avoided, and the consistency of the efficacy of the spray and the reliability of long-term preservation are ensured. BRIEF DESCRIPTION OF THE DRAWINGS

[0085] Figure 1 A schematic diagram of the components of the Chinese medicine spray for treating neck, shoulder, waist and leg pain of the present invention;

[0086] Figure 2 It is a schematic diagram of the physical and chemical properties of the Chinese medicine spray of the present invention;

[0087] Figure 3 This is a schematic diagram of the composition ratio range of the Chinese medicine spray of the present invention;

[0088] Figure 4 The present invention is a flow chart of the method for preparing the Chinese medicine spray;

[0089] Figure 5 This is a flow chart of medicinal material crushing and humidity control of the present invention;

[0090] Figure 6 The present invention is a flow chart of stirring and alcohol concentration monitoring during the soaking process. DETAILED DESCRIPTION

[0091] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0092] See also Figures 1 to 6The present invention relates to a pure Chinese medicine spray for treating neck, shoulder, waist and leg pain. The spray is formed by combining the effective ingredients of multiple Chinese medicinal materials with 75% alcohol as a solvent to form an external spray product with rapid penetration and analgesic effect. The formula and use method of the product are intended to solve the problems of poor drug penetration, short-lasting efficacy, inconvenience in use and large side effects in existing treatment methods. The ingredients include:

[0093] Main active ingredient group: The main active ingredient group includes processed Chuanwu, processed Caowu, processed Tiannanxing, processed Strychnos nux vomica and earthworm. Each medicinal material has a unique pharmacological effect in traditional Chinese medicine theory, which is specifically manifested in the following aspects:

[0094] Processed Chuanwu and processed Caowu: These two Chinese medicinal ingredients are commonly used to treat rheumatic pain and have a strong analgesic effect. By combining with other ingredients, the analgesic effect of this spray is enhanced.

[0095] Processed Arisaema: It has the effect of dispelling wind and dampness, and is often used to treat pain caused by rheumatism and phlegm-dampness blockage, and enhances the effect of this spray in alleviating local inflammation.

[0096] Processed Strychnos nux vomica: Its functions of promoting blood circulation, unblocking meridians, reducing swelling and relieving pain play a role in regulating qi and blood, and relieving stiffness and pain in the compound formula of the present invention.

[0097] Pheromone: Also known as earthworm, it has the effect of clearing meridians, relieving pain and dispelling wind, which enhances the durability of the spray in relieving pain.

[0098] These main active ingredients work together in the Chinese medicine compound and act directly on the affected area in the form of a spray, which can quickly relieve pain and have a significant anti-inflammatory effect. Compared with traditional oral drugs, these Chinese medicines reach the lesion site directly through external application, avoiding the loss of drugs through the gastrointestinal tract.

[0099] Blood circulation and stasis removal ingredient group: The blood circulation and stasis removal ingredient group includes safflower, tetrandra, acanthopanax bark, vinegar frankincense, scalded bone drynaria, vinegar myrrh and dragon's blood. The main functions of these ingredients are to promote blood circulation, reduce swelling and relieve pain, and accelerate the repair process of damaged tissues:

[0100] Safflower: It has the effect of promoting blood circulation and removing blood stasis, which helps to promote local blood circulation and thus accelerate the healing of the lesion area.

[0101] Han Fang Ji and Acanthopanax Acanthopanax Cortex: These Chinese herbs are mainly used to eliminate dampness, heat and rheumatism, and can reduce inflammation and relieve pain.

[0102] Vinegar frankincense and vinegar myrrh: Both have strong blood circulation and analgesic effects, and their transdermal absorption effect is enhanced by vinegar processing.

[0103] Xuejie: ​​It is a well-known blood-activating and blood-stasis-removing medicine that can effectively promote the repair of damaged tissues and further enhance the deep effects of the medicine.

[0104] The blood-activating and blood-stasis-removing ingredient group enhances the drug's sustained efficacy on chronic lesions by promoting blood circulation, removing blood stasis, unblocking meridians and relieving pain, especially in relieving symptoms such as long-term stiffness and limited mobility.

[0105] Aromatic ingredient group: The aromatic ingredient group includes borneol, menthol, and camphor. The main function of these ingredients is to enhance the penetration of the spray and the local cooling feeling:

[0106] Borneol: used in topical medications, it can accelerate the penetration of other drug ingredients and achieve a cooling and analgesic effect.

[0107] Menthol and camphor: have cooling, antipruritic and analgesic effects, and can enhance skin permeability and drug penetration.

[0108] The addition of the aromatic ingredient group enables the spray to quickly bring a comfortable cooling sensation when used, helping patients to quickly perceive the pain relief effect.

[0109] Solvent group: This component uses 75% alcohol as a solvent, which can not only effectively extract the drug ingredients, but also has good transdermal permeability. Alcohol itself has a bactericidal effect, which can ensure that the spray reduces the risk of infection during use. Compared with oily solvents, alcohol solvents can evaporate quickly, ensuring that the drug solution is quickly absorbed after spraying, and will not leave a greasy feeling on the skin surface.

[0110] In the main active ingredient group, the ratio of processed Chuanwu, processed Caowu, processed Tiannanxing, processed Strychnos nux vomica, and earthworm is 100-300 parts, and further refined to 150-250 parts. This ratio can ensure that each active ingredient can achieve the therapeutic effect while avoiding overdose and preventing toxic side effects.

[0111] The proportion of each drug in the blood-activating and blood-stasis-removing component group ranges from 50 to 150 parts, and is accurate to 75 to 125 parts. This range ensures the high efficiency of the drugs in promoting blood circulation and accelerating the recovery of lesions.

[0112] The specific ratio of borneol, menthol and camphor in the aromatic ingredient group is 30-60 parts, which can ensure that the drug maintains a good cooling feeling while avoiding skin irritation caused by excessive drug concentration.

[0113] The amount of alcohol used in the solvent group is controlled at 6000-12000 parts, and further refined to 9000-10000 parts. This amount of solvent can not only ensure the full dissolution of the active ingredients, but also ensure the good fluidity and spray effect of the spray during use.

[0114] The working principle of the present invention is based on the theory of Chinese medicine for promoting blood circulation, removing blood stasis, removing rheumatism, unblocking meridians and relieving pain. The main active ingredients act directly on the affected area in the form of a spray, quickly penetrate the skin, and reach the lesion site, achieving analgesic and swelling-reducing effects. Compared with traditional patches and ointments, the alcohol solvent in the present invention can quickly carry the drug to penetrate into the lesion site, greatly shortening the time for the drug to take effect. At the same time, the blood circulation and blood stasis-removing ingredients can accelerate blood circulation, reduce inflammation, and help the affected area recover; the aromatic ingredients can reduce the patient's discomfort through a local cooling sensation, thereby improving the patient's experience of use.

[0115] Through this design, the present invention can effectively solve the problem of difficult pain relief and poor drug permeability faced by patients with neck, shoulder, waist and leg pain for a long time. At the same time, since the Chinese medicine components in the present invention are highly safe and have no side effects, they are suitable for long-term use, avoiding the side effects that may be caused by traditional Western medicine in the process of relieving pain.

[0116] The Chinese medicine spray is simple in form, easy to carry and use, and is particularly suitable for patients with chronic pain who require long-term treatment. It can effectively improve patients' compliance and quality of life.

[0117] Among them: The powder fineness range of the main active ingredient group is 80-120 mesh: When preparing the spray, the Chinese medicinal materials of the main active ingredient group need to be crushed to a fineness of 80-120 mesh. The selection of this fineness range is particularly critical. Medicinal materials with higher powder fineness (smaller fineness) help the drug ingredients to dissolve more quickly and evenly in alcohol, thereby improving the bioavailability of the drug. Too coarse powder may reduce the solubility of the drug and affect the release of the drug effect. The 80-120 mesh range can ensure that the active ingredients of the medicinal materials are fully dissolved and avoid precipitation or granularity of the medicinal materials in the preparation, thereby ensuring the stability and uniformity of the spray.

[0118] The viscosity of the liquid medicine after the blood-activating and stasis-removing component group is dissolved is 10-15mPa·s: The viscosity of the liquid medicine after the blood-activating and stasis-removing component group is dissolved is controlled at 10-15mPa·s. The viscosity of the liquid medicine directly affects the fluidity and spraying effect of the spray. Higher viscosity will make the spray difficult to spray or unevenly sprayed, while lower viscosity may affect the residence time and absorption effect of the drug on the skin. The viscosity range of 10-15mPa·s ensures that the liquid medicine has good fluidity when sprayed, while ensuring that the drug is evenly distributed on the skin and maintains appropriate adhesion, which facilitates the effective absorption of the drug.

[0119] The volatilization rate of borneol and menthol in the aromatic ingredient group is 10-20 minutes: the borneol and menthol in the aromatic ingredient group should volatilize within 10-20 minutes after spraying. The control of the volatilization rate affects the user experience and efficacy of the spray. The volatilization time of 10-20 minutes can not only provide a long enough cooling sensation to help relieve local pain and discomfort, but also avoid the instantaneous effect disappearance caused by too fast volatilization. During this period of time, the drug ingredients can penetrate into the skin, and the moderate volatilization of menthol and borneol can also enhance transdermal absorption and provide a comfortable user experience.

[0120] The evaporation rate of 75% alcohol in the solvent group is 20-30 minutes: 75% alcohol as a solvent has an evaporation rate of 20-30 minutes. This evaporation rate ensures that the spray has enough time to stay on the skin surface after spraying, so that the drug can be fully absorbed. If the alcohol evaporates too quickly, the drug may be taken away before it is fully penetrated, and if it evaporates too slowly, it may cause skin discomfort and drug accumulation. The evaporation time of 20-30 minutes can effectively promote the transdermal absorption of drugs and keep the skin dry and comfortable.

[0121] The atomized particle size of the spray is in the range of 10-50 microns: The size of the atomized particles of the spray determines the uniformity of the spray and the coverage of the drug on the skin surface. The particle size range of 10-50 microns ensures that the spray forms a fine mist that can evenly cover a large area of ​​the skin surface without forming large droplets or fine spray. This not only avoids the waste of drug solution, but also enables the drug to contact the skin more evenly and improves the absorption of drug efficacy.

[0122] pH range is 5.5-7.0: The pH value of the spray is controlled between 5.5-7.0, close to the natural pH value of the skin (usually between 4.5-6.5), which makes the spray mild and non-irritating to the skin during use. Higher or lower pH values ​​may cause skin irritation or damage the skin barrier. By controlling the pH value within this range, the spray can not only maintain the activity of the drug, but also adapt to different skin types and avoid allergic reactions.

[0123] The density of the liquid is 0.90-1.10g / cm 3 :The density of the liquid is controlled at 0.90-1.10g / cm 3 This range ensures a reasonable ratio of drug ingredients to alcohol solvent. Appropriate density ensures the fluidity of the spray, allowing it to be sprayed smoothly through the nozzle and not easily accumulated or blocked during use. In addition, the appropriate density can help the drug be evenly distributed on the skin surface and improve the permeability of the drug ingredients.

[0124] Surface tension is 30-50mN / m: The surface tension of the drug solution is controlled between 30-50mN / m. This range ensures that the drug solution can spread quickly on the skin surface. Too high a surface tension may make it difficult for the spray to evenly cover the skin, while too low a surface tension may cause the drug solution to spread excessively, affecting the efficacy. By controlling the surface tension within a reasonable range, it is ensured that the spray can not only evenly cover the skin, but also maintain an appropriate drug concentration on the skin to promote effective absorption;

[0125] The preparation method of the Chinese medicine spray of the present invention refines each step from raw material preparation to packaging to ensure the stability, efficacy and safety of the medicine. The method controls the operation of each link through precise steps, so that the Chinese medicine components can be fully extracted and converted into a spray form with long-lasting efficacy and easy to use.

[0126] S1. Raw material preparation

[0127] S1.1. According to the formula ratio, weigh processed Chuanwu, processed Caowu, processed Tiannanxing, processed Strychnos nux vomica, earthworm, safflower, Hanfangji, vinegar frankincense, vinegar myrrh, scalded bone drynaria, and Acanthopanax acanthopanax. In this step, all Chinese medicinal materials are accurately weighed according to the ratio specified in the claims. This step is the key to ensure the consistency of drug efficacy. Any ratio error may lead to insufficient efficacy or increased side effects. The 11 kinds of Chinese medicinal materials cover multiple therapeutic effects such as promoting blood circulation, reducing swelling, relieving pain, and removing rheumatism. After accurate weighing, they can work synergistically.

[0128] S1.2. Check the quality of each Chinese herbal medicine to ensure that there are no impurities or mildew: During the preparation stage, all herbs must be strictly checked to ensure that they are free of impurities or mildew. Unqualified herbs will not only reduce the efficacy of the spray, but may also pose a safety hazard. Therefore, quality control is the basis for ensuring the quality of the medicine.

[0129] S1.3. Grind all medicinal materials to a fineness of 80-120 mesh to facilitate the extraction of active ingredients: The degree of grinding of medicinal materials directly affects the extraction effect of the drug. By grinding the medicinal materials to a fineness range of 80-120 mesh, the surface area of ​​the medicinal materials can be increased, thereby promoting the release of active ingredients during subsequent soaking and extraction. If the grinding is not fine enough, the active ingredients in the medicinal materials may not be fully dissolved; if it is too fine, it may cause precipitation problems.

[0130] S2. Soak

[0131] S2.1. Place the crushed medicinal materials into a stainless steel soaking container: Using a stainless steel soaking container can prevent the components in the medicinal solution from chemically reacting with the container, ensuring the stability of the medicinal components and at the same time ensuring that the medicinal solution is not contaminated by the outside world during the soaking process.

[0132] S2.2, add 75% alcohol, the ratio of alcohol to medicinal materials is 10:1: 75% alcohol can not only be used as an effective solvent to extract the active ingredients in the medicinal materials, but also has the effect of sterilization and preservation. The ratio of alcohol to medicinal materials is set to 10:1. This ratio ensures that the medicinal materials can be completely soaked in alcohol, thereby ensuring the effective extraction of active ingredients.

[0133] S2.3. Ensure that the medicinal materials are completely immersed and the container is sealed: Completely immersing the medicinal materials can avoid incomplete extraction due to insufficient contact of some medicinal materials during the extraction process. The sealed container can prevent alcohol from evaporating and maintain the concentration of the medicinal solution.

[0134] S2.4. Soak for 30 days, stirring once a day to ensure full contact between the medicinal materials and the alcohol: 30 days of soaking can ensure that the active ingredients in the medicinal materials are fully released. Daily stirring can increase the contact area between the medicinal materials and the alcohol, so that the ingredients in the medicinal materials can be fully extracted, improve the extraction efficiency and maintain the uniformity of the liquid medicine.

[0135] S3. Heating extraction

[0136] S3.1. Transfer the soaked medicinal liquid to the steaming device: After soaking, the medicinal liquid is transferred to the steaming device. Heating extraction can further release the insoluble components in the medicinal materials and enhance the efficacy.

[0137] S3.2, heating to 85-95℃ and maintaining for 1-2 hours: Heating within the temperature range of 85-95℃ can effectively accelerate the release of drug ingredients, and maintaining for 1-2 hours can ensure sufficient drug extraction. Too low a temperature may lead to incomplete extraction, and too high a temperature may destroy the activity of some drug ingredients.

[0138] S3.3. Stir continuously during the process to ensure that the medicine liquid is heated evenly: Continuous stirring during the heating process can ensure that the medicine liquid is heated evenly, prevent local overheating or deposition, and improve the extraction efficiency of the active ingredients.

[0139] S3.4. Cool the liquid to room temperature after completion: After the extraction is completed, the liquid needs to be cooled to room temperature for subsequent filtration and processing. Rapid cooling can avoid the decomposition of components or loss of efficacy that may occur in a high temperature environment for a long time.

[0140] S4. Filtering

[0141] S4.1. Use a 200-mesh filter to filter the extracted medicinal liquid to remove the residue: Filtration is to remove the residue and ensure the purity of the medicinal liquid. The 200-mesh filter can effectively filter out larger medicinal residues to ensure the clarity and uniformity of the medicinal liquid.

[0142] S4.2. If further clarification is required, perform secondary filtration to ensure that the liquid medicine is clear and free of impurities: For liquid medicines with higher purity requirements, secondary filtration can further remove finer impurities, ensure the clarity of the liquid medicine, and prevent the spray from clogging the nozzle or affecting the absorption effect during use.

[0143] S4.3. Collect the filtered liquid medicine in a clean container for later use: The filtered liquid medicine must be stored in a clean container to prevent subsequent contamination or deterioration and ensure the stable quality of the spray.

[0144] S5, Mixed

[0145] S5.1. Add dragon's blood, borneol, menthol and camphor into the clarified liquid medicine in proportion one by one: dragon's blood, borneol, menthol and camphor have special medicinal effects and physical and chemical properties. They are added in proportion after the liquid medicine is clarified to ensure the analgesic, anti-rheumatic and cooling and soothing effects of the spray.

[0146] S5.2. Stir evenly to ensure that all ingredients are fully dissolved: All ingredients are fully dissolved in the liquid medicine to ensure the uniformity of the spray. If the ingredients are not evenly distributed, it may affect the efficacy of the spray or cause adverse reactions.

[0147] S5.3. Stirring time is 30 minutes to ensure uniform distribution of ingredients: 30 minutes of stirring time can ensure that all added ingredients are fully dissolved and evenly distributed in the medicine solution to prevent stratification of the drug in the bottle.

[0148] S6. Settle

[0149] S6.1. Place the mixed liquid medicine in a clean container and let it stand for 24 hours: The 24-hour standing process allows the suspended matter and tiny particles in the liquid medicine to settle naturally, ensuring the clarity of the supernatant.

[0150] S6.2. Maintain room temperature and avoid direct sunlight to prevent the drug solution from volatilizing or deteriorating: the drug solution needs to be left standing in a dark place to avoid chemical reactions caused by sunlight and ensure the stability of the drug solution.

[0151] S6.3. After standing, take the supernatant and discard the precipitate: After standing, the supernatant can be directly used for subsequent packaging, while the precipitate should be discarded to ensure the purity and uniformity of the solution.

[0152] S7, Packaging

[0153] S7.1. Dispense the supernatant into sterile spray bottles to ensure aseptic operation: The dispensing process must be carried out under sterile conditions to prevent the drug solution from being contaminated during the dispensing process and to ensure the hygiene and safety of the product.

[0154] S7.2. Each bottle is filled to the specified capacity to avoid wasting of liquid medicine: Fill according to the specified capacity to ensure the consistency of dosage of each bottle of product and avoid wasting liquid medicine.

[0155] S7.3. Seal after packaging to ensure good sealing: Seal the container immediately after packaging to prevent the drug solution from evaporating or deteriorating and ensure the long-term stability of the product.

[0156] Further settings in step S1:

[0157] The fineness of the medicinal materials is controlled within 80-120 mesh: The fineness of the medicinal materials is crucial to the subsequent extraction process. Controlling it within the range of 80-120 mesh can ensure that the medicinal materials have sufficient surface area to facilitate the full release of active ingredients during the soaking and heating extraction process. Too coarse powder will reduce the extraction efficiency, while too fine powder may cause drug residues to be produced during extraction, increasing the difficulty of filtration.

[0158] Immediately after the crushing is completed, perform a humidity test to ensure that the humidity is not higher than 8%: Controlling the humidity below 8% is an important step to ensure that the medicinal materials are not easily affected by moisture and mold. Excessive humidity will affect the preservation of medicinal materials, causing them to deteriorate or weaken their efficacy. Through humidity testing, it is possible to promptly find out whether the medicinal materials meet the drying standards and avoid quality problems in the subsequent processing of medicinal materials.

[0159] If the humidity of the medicinal materials exceeds the standard, they can be dried at a temperature of 30-40°C, and the drying time is controlled within 4-6 hours: If the humidity exceeds the standard of 8%, they can be dried at a low temperature of 30-40°C. This temperature range can avoid the damage of high temperature to the effective ingredients of the medicinal materials, and can effectively reduce the moisture content of the medicinal materials. The drying time is controlled within 4-6 hours, which can ensure that the medicinal materials are dry without damaging their efficacy.

[0160] The soaking process in step S2 is specified in detail to ensure that the medicinal materials are in full contact with the solvent during the soaking process and that the alcohol concentration is stable.

[0161] Use a stirring device to stir continuously at a low speed, each stirring lasts for 15 minutes, and the stirring interval is 2 hours: During the soaking process, the use of a stirring device can prevent the precipitation of medicinal materials and improve the contact efficiency between medicinal materials and solvents. Each stirring lasts for 15 minutes to effectively mix the medicinal materials and alcohol, so that the active ingredients in the medicinal materials are released evenly. The stirring interval is 2 hours, which can ensure sufficient extraction during the soaking process without excessively disturbing the medicinal solution and affecting the soaking effect.

[0162] Conduct an alcohol concentration test on the 15th and 30th days of soaking to ensure that the 75% alcohol concentration is stable: As the soaking time increases, the alcohol may evaporate or be absorbed by the medicinal materials, so conducting alcohol concentration tests in the middle and at the end of the soaking is an important step to ensure the efficiency of drug extraction. If the alcohol concentration drops, the drug extraction effect will be affected, and testing helps ensure that the concentration is always maintained at 75%.

[0163] If there is a loss, add alcohol to the required concentration to prevent insufficient extraction of the active ingredients: If the test results show that the alcohol concentration is reduced, it is necessary to immediately add alcohol to restore it to 75% concentration to ensure that the active ingredients are fully extracted during the soaking process and avoid insufficient extraction due to insufficient alcohol concentration;

[0164] The heating extraction process in step S3 is precisely controlled to ensure the quality of the drug solution and the extraction of effective ingredients.

[0165] Use constant temperature heating equipment to keep the temperature within the range of 90℃±2℃: Temperature control during heating extraction is an important step to ensure that the active ingredients in the medicinal materials are fully released. Constant temperature heating equipment can ensure temperature stability during the heating process and avoid the impact of temperature fluctuations on the extraction effect. Controlling the temperature within the range of 90℃±2℃ can balance the stability of the drug ingredients and the extraction efficiency, and prevent excessive temperature from destroying the activity of the drug.

[0166] The volatilization rate of the solution needs to be monitored during the heating process and controlled within 1% of the total liquid volume: During heating extraction, the volatilization of alcohol is inevitable, so the volatilization rate needs to be strictly monitored. If the volatilization volume exceeds 1%, it may cause the alcohol concentration to decrease, thereby affecting the extraction effect of the medicinal ingredients. Therefore, controlling the volatilization rate within 1% can ensure that the concentration of the solvent remains stable and avoid a decrease in extraction efficiency.

[0167] After the extraction is completed, the liquid medicine is quickly cooled in a vacuum environment to below 25°C and immediately sealed for storage: Rapid cooling of the liquid medicine can prevent further decomposition or evaporation of the drug components during the extraction process. Cooling in a vacuum environment can prevent impurities or moisture in the air from entering the liquid medicine, ensuring the purity and stability of the liquid medicine. After cooling to below 25°C, the liquid medicine is immediately sealed for storage to ensure that it is not affected by environmental factors during subsequent use.

[0168] The filtration process in step S4 is specified in detail to ensure the clarity and purity of the drug solution.

[0169] The filtration process is divided into two steps: the first step is to filter out coarse impurities through a 200-mesh primary filter, and the second step is to perform deep filtration through a 0.45-micron precision filter membrane: The primary filtration process is mainly used to remove larger medicinal material residues and impurities to ensure the basic purity of the liquid medicine. Most insoluble matter can be filtered out efficiently through a 200-mesh filter. However, there may still be tiny impurities in the liquid medicine, so secondary filtration is required. The 0.45-micron precision filter membrane can deeply filter out tiny particles and suspended matter, ensuring the clarity of the liquid medicine and the quality of the final spray product.

[0170] The filtered liquid medicine is stored in a sterile environment and is subsequently processed within 24 hours: The liquid medicine after precision filtration is very susceptible to contamination, so it must be stored in a sterile environment to prevent external bacteria or impurities from contaminating the liquid medicine. In order to ensure the freshness and efficacy of the liquid medicine, it is recommended to perform subsequent processing within 24 hours, such as mixing with other ingredients or packaging.

[0171] Example 1: Treatment of neck and shoulder pain for long-term office workers

[0172] Long-term desk workers (such as office workers, programmers, etc.) are prone to neck and shoulder pain problems due to improper posture or long-term sitting. Traditional treatments include oral analgesics, physical therapy, and topical patches, but these methods are either prone to gastrointestinal discomfort or have short-term effects, and it is difficult to meet the needs of long-term pain relief. In addition, the office environment usually requires that the treatment method is convenient, has no obvious odor, and does not affect daily work. The Chinese medicine spray of the present invention is combined with an alcohol solvent through a compound Chinese medicine formula, has a good transdermal absorption effect, can quickly relieve pain and maintain a lasting effect, and is particularly suitable for the pain treatment needs in this office scene.

[0173] The technical purpose of this embodiment is to provide a treatment method for relieving neck and shoulder pain caused by improper posture in long-term desk workers. The spray formula can be absorbed quickly without affecting work, and at the same time has good long-term effectiveness, avoiding frequent use of drugs.

[0174] The innovation of this invention is that it combines a variety of traditional Chinese medicine compounds with 75% alcohol solvent, so that the drugs can quickly penetrate the skin and reach the lesions directly. The application scenario is mainly for long-term desk workers, especially when used in an office environment. It is easy to use, has no obvious odor, and has a long-lasting analgesic effect.

[0175] Experimental comparison

[0176] In order to verify the effect of the spray of the present invention, 30 long-term office workers with neck and shoulder pain were selected as experimental subjects and divided into three groups: a group using the spray of the present invention, a group using traditional analgesic patches, and a group using oral analgesics. The experiment observed the pain relief time, the duration of the therapeutic effect, and the incidence of adverse reactions after use.

[0177]

[0178] Results Analysis

[0179] Pain relief time: The spray of the present invention can quickly relieve pain within 10-15 minutes, which is better than traditional analgesic patches and close to the relief time of oral analgesics.

[0180] Duration of efficacy: The spray's efficacy lasts for 8-10 hours, which is significantly better than traditional patches and slightly longer than oral medications, and can effectively reduce the frequency of use.

[0181] Convenience of use: The spray of the present invention is easy to use, does not need to be applied or taken orally, and is suitable for immediate use in a working environment.

[0182] Adverse reactions: There were no obvious adverse reactions in the spray group, 1 case of skin allergy occurred in the traditional analgesic patch group, and 2 cases of gastrointestinal discomfort occurred in the oral medication group.

[0183] Example 2: Treatment of low back and leg pain in patients with rheumatoid arthritis

[0184] Patients with rheumatoid arthritis often suffer from back and leg pain, especially when the climate changes. Traditional treatments mostly use oral nonsteroidal anti-inflammatory drugs (NSAIDs) and local physical therapy, but long-term use of NSAIDs can cause gastrointestinal discomfort and liver and kidney damage, and physical therapy requires professional equipment and personnel to operate. The Chinese medicine spray of the present invention can quickly play a role in the local area, relieve pain, and avoid the side effects of oral drugs through the compound ratio of Chinese medicine ingredients such as promoting blood circulation and removing blood stasis, dispelling wind and removing dampness, and is suitable for daily use.

[0185] The technical purpose of this embodiment is to provide a safe and convenient external spray for the treatment of low back and leg pain in patients with rheumatoid arthritis, which can effectively relieve pain and improve blood circulation, is suitable for long-term use and has no side effects.

[0186] The innovation of the present invention is that it combines a variety of Chinese medicinal materials with the effects of promoting blood circulation, removing blood stasis and removing rheumatism, such as safflower, fangji, and processed chuanwu, so that the medicine can not only relieve pain, but also improve the circulation of the lesion site in long-term use. The spray is particularly suitable for self-use at home, without professional operation, and is suitable for daily care of patients with long-term rheumatic arthritis.

[0187] In the comparative experiment, 20 patients with rheumatoid arthritis were selected and divided into two groups: a group using the spray of the present invention and a group using oral NSAIDs drugs, and the pain relief, sustained effect and effect on the gastrointestinal tract after long-term use were observed.

[0188]

[0189]

[0190] Results Analysis

[0191] Pain relief time and duration: The spray of the present invention is similar to oral NSAIDs in pain relief time, both within 15-20 minutes, but the efficacy of the present invention lasts longer.

[0192] Safety of long-term use: The spray group of the present invention did not experience gastrointestinal discomfort or other side effects after long-term use, while 3 cases of gastrointestinal discomfort and 2 cases of abnormal liver and kidney function in the oral NSAIDs group showed higher safety.

[0193] Convenience of use: The spray can be directly sprayed on the painful area, which is easy to use and especially suitable for patients with rheumatoid arthritis who need long-term use.

[0194] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A pure Chinese medicine spray for treating neck, shoulder, waist and leg pain, characterized by: The Chinese medicine spray is composed of the following components: The main active ingredient group: processed Chuanwu, processed Caowu, processed Tiannanxing, processed Strychnos nux vomica, and earthworm; Blood circulation and stasis-removing ingredient group: safflower, tetrandra chinensis, acanthopanax cortex, vinegar frankincense, scalded drynaria, vinegar myrrh, and dragon's blood; Aromatic ingredient group: borneol, menthol, camphor; Solvent group: 75% alcohol.

2. A pure Chinese medicine spray for treating neck, shoulder, waist and leg pain according to claim 1, characterized in that: The proportion range of each component is as follows: Main medicinal ingredient group: Processed Chuanwu: 100-300 portions; Processed Radix Aconiti Kusnezoffii: 100-300 portions; Processed Arisaema: 100-300 portions; Prepared Strychnos nux vomica: 100-300 portions; Earthworm: 100-300 servings; Blood circulation and blood stasis removing ingredient group: Safflower: 50-150 parts; Radix Stephaniae Tetrandrae: 50-150 parts; Acanthopanax Cortex: 50-150 servings; Vinegar frankincense: 50-150 parts; Scalded Drynaria fortunei: 50-150 servings; Vinegar myrrh: 50-150 parts; Dragon's blood: 50-100 portions; Fragrance ingredient group: Borneol: 30-60 parts; Menthol: 30-60 parts; Camphor: 60-120 parts; Solvent Group: 75% alcohol: 6000-12000 parts.

3. A pure Chinese medicine spray for treating neck, shoulder, waist and leg pain according to claim 2, characterized in that: The specific ratio range of the Chinese medicine spray is Main active ingredient group: The proportion of processed Chuanwu, processed Caowu, processed Tiannanxing, processed Strychnos nux vomica and earthworm is 150-250 parts; Blood circulation and blood stasis removing ingredient group: The proportion of safflower, fangji, acanthopanax bark, vinegar frankincense, scalded drynaria, vinegar myrrh is 75-125 parts; The ratio of Dragon's Blood is 60-80 parts; Fragrance ingredient group: The ratio of borneol and menthol is 40-50 parts; The proportion range of camphor is: 80-100 parts; Solvent Group: The mixing ratio range of 75% alcohol is: 9000-10000 parts.

4. A pure Chinese medicine spray for treating neck, shoulder, waist and leg pain according to claim 3, characterized in that: The powder fineness of the main active ingredient group is in the range of 80-120 meshes, the viscosity of the dissolved liquid of the blood-activating and blood-stasis-removing ingredient group is 10-15 mPa·s, the volatilization speed of borneol and menthol in the aromatic ingredient group is 10-20 minutes, the evaporation rate of 75% alcohol in the solvent group is 20-30 minutes, the atomized particle size of the spray is in the range of 10-50 microns, the pH value is in the range of 5.5-7.0, and the liquid density is 0.90-1.10 g / cm 3 , the surface tension is 30-50mN / m.

5. A method for preparing a pure Chinese medicine spray for treating cervical, shoulder, waist and leg pain, used for the pure Chinese medicine spray for treating cervical, shoulder, waist and leg pain according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1. Raw material preparation: S1.

1. Weigh processed Chuanwu, processed Caowu, processed Arisaema, processed Strychnos nux vomica, earthworm, safflower, Tetrandrakia tetrandra, vinegar frankincense, vinegar myrrh, scalded Drynariae Rhizoma, Acanthopanax acanthopanax Cortex according to the formula ratio; S1.

2. Check the quality of each Chinese herbal medicine to ensure that there are no impurities or mildew; S1.3, crush all medicinal materials to 80-120 mesh fineness to facilitate the extraction of active ingredients; S2. Soaking: S2.

1. Place the crushed medicinal materials into a stainless steel soaking container; S2.2, add 75% alcohol, the ratio of alcohol to medicinal materials is 10:1; S2.

3. Ensure that the medicinal materials are completely submerged and seal the container; S2.

4. Soak for 30 days, stirring once a day to ensure that the medicinal materials are fully in contact with the alcohol; S3, heating extraction: S3.1, transferring the soaked liquid to the cooking device; S3.2, heat to 85-95°C and maintain for 1-2 hours; S3.

3. Stir continuously during the process to ensure that the liquid is heated evenly; S3.

4. After completion, cool the solution to room temperature; S4. Filtering: S4.

1. Filter the extracted liquid medicine using a 200-mesh filter to remove the medicine residue; S4.

2. If further clarification is required, perform secondary filtration to ensure that the liquid medicine is clear and free of impurities; S4.

3. Collect the filtered liquid medicine in a clean container for later use; S5, Mixed: S5.

1. Add dragon's blood, borneol, menthol and camphor into the clarified liquid medicine in proportion; S5.

2. Stir evenly to ensure that all ingredients are fully dissolved; S5.3, stirring duration is 30 minutes to ensure uniform distribution of ingredients; S6. Settling: S6.

1. Place the mixed solution in a clean container and let it stand for 24 hours; S6.

2. Keep the temperature at room temperature and avoid direct sunlight to prevent the liquid from volatilizing or deteriorating; S6.

3. After standing, take the supernatant and discard the precipitate; S7, Packaging: S7.

1. Dispense the supernatant into sterile spray bottles to ensure aseptic operation; S7.

2. Each bottle should be filled to the specified capacity to avoid wasting of liquid medicine; S7.

3. Seal after packaging to ensure good sealing.

6. The method for preparing a pure Chinese medicine spray for treating neck, shoulder, waist and leg pain according to claim 5, characterized in that: In step S1, the grinding fineness of all medicinal materials is controlled at 80-120 meshes. After the grinding is completed, a humidity test is immediately carried out to ensure that the humidity is not higher than 8%. If the humidity of the medicinal materials exceeds the standard, they are dried at a temperature of 30-40°C for 4-6 hours. They can only be stored after the humidity reaches the standard.

7. The method for preparing a pure Chinese medicine spray for treating neck, shoulder, waist and leg pain according to claim 5, characterized in that: In step S2, a stirring device is used to continuously stir at a low speed during the soaking process. Each stirring lasts for 15 minutes, and the stirring interval is 2 hours. An alcohol concentration test is performed on the 15th and 30th days of soaking to ensure that the 75% alcohol concentration is stable. If there is any loss, alcohol is supplemented to the required concentration to prevent insufficient extraction of the active ingredients.

8. The method for preparing a pure Chinese medicine spray for treating neck, shoulder, waist and leg pain according to claim 5, characterized in that: In step S3, a constant temperature heating device is used for heating extraction, and the temperature is maintained within the range of 90°C ± 2°C. The volatility of the solution needs to be monitored during the heating process and controlled within 1% of the total liquid volume. After the extraction is completed, the drug solution is rapidly cooled in a vacuum environment to below 25°C, and is immediately sealed and stored.

9. The method for preparing a pure Chinese medicine spray for treating neck, shoulder, waist and leg pain according to claim 5, characterized in that: In step S4, the filtration process is divided into two steps: the first step is to filter out coarse impurities through a 200-mesh primary filter, and the second step is to perform deep filtration through a 0.45-micron precision filter membrane to ensure the clarity of the drug solution; The filtered drug solution was stored under sterile conditions and subsequently processed within 24 hours.

Images