Traditional Chinese medicine composition capable of bidirectionally regulating blood pressure as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to a traditional Chinese medicine composition for bidirectionally regulating blood pressure and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for bidirectionally regulating the blood pressure is prepared from the following raw materials in parts by weight: 0.2 to 20 parts of cortex eucommiae, 0.12 to 12 parts of rhizoma gastrodiae, 0.15 to 15 parts of fructus lycii, 0.1 to 10 parts of mulberry fruit, 0.12 to 12 parts of radix puerariae, 0.12 to 12 parts of fructus corni, 0.08 to 8 parts of herba cistanche, 0.05 to 0.5 part of cortex cinnamomi, 0.15 to 15 parts of cortex acanthopanacis, 0.15 to 15 parts of oyster, 0.05 to 5 parts of gallnut, 0.08 to 8 parts of uncaria and 0.1 to 10 parts of spica prunellae. The invention further discloses a preparation method and application of the traditional Chinese medicine composition capable of bidirectionally regulating the blood pressure. The traditional Chinese medicine composition capable of bidirectionally regulating the blood pressure can achieve the technical effects of bidirectionally regulating the blood pressure and stabilizing the pressure, and can be used for preparing medicines for bidirectionally regulating the blood pressure.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for bidirectionally regulating blood pressure, and a preparation method and application thereof. Background Art

[0002] Abnormal blood pressure, high or low, is a common cardiovascular disease, which is extremely harmful to the human body. Hypertension refers to systolic blood pressure ≥140mmHg and diastolic blood pressure ≥90mmHg. Hypertension belongs to the category of "dizziness" and "headache" in traditional Chinese medicine, and is divided into liver yang hyperactivity type, liver and kidney yin deficiency type, yin and yang deficiency type, yin deficiency yang hyperactivity type, wind phlegm type, etc.

[0003] There is no exact numerical definition for hypotension. Generally speaking, when the systolic blood pressure is less than 90 mmHg and the diastolic blood pressure is less than 60 mmHg, it can be called hypotension or hypotension state. Traditional Chinese medicine believes that hypotension is mainly caused by deficiency of heart and spleen yang, insufficient yang qi, and weak blood circulation. A series of symptoms such as dizziness and syncope are caused by lowered blood pressure. These symptoms are mainly caused by a drop in blood pressure, which leads to slow blood circulation and ischemia of distal capillaries, thus affecting the supply of oxygen and nutrients to tissue cells, and the excretion of carbon dioxide and metabolic waste. In particular, it affects the blood supply to the brain and heart. Long-term treatment greatly reduces the body's functions. The main hazards include: decreased vision and hearing, inducing or aggravating senile dementia, greatly increasing the incidence of dizziness, syncope, falls, and fractures, and frequent occurrence of fatigue, mental fatigue, depression, and melancholy, which affects the quality of life of patients.

[0004] At present, the treatment of blood pressure regulation in my country is mainly based on Western medicine, which has limited effects, only treats the symptoms but not the root cause, has side effects when taken for a long time, often causes many adverse reactions, accelerates cardiovascular and cerebrovascular diseases, and increases drug resistance. Traditional Chinese medicine has the advantages of multiple pathways, multiple targets, and few side effects, and is increasingly valued in the treatment of blood pressure.

[0005] Since the causes of hypertension and hypotension are different, drugs that regulate blood pressure generally regulate blood pressure in a unidirectional manner. Hypertension drugs can only treat hypertension but have no effect on hypotension. Conversely, drugs that treat hypotension can only treat hypotension but not hypertension, thus failing to achieve the purpose of bidirectional regulation and stabilization of blood pressure.

[0006] In view of this, the present invention provides a Chinese medicine composition for bidirectionally regulating blood pressure, and a preparation method and application thereof, in order to achieve the technical effect of bidirectionally regulating blood pressure. Summary of the invention

[0007] One of the purposes of the present invention is to provide a Chinese medicine composition for bidirectionally regulating blood pressure.

[0008] The technical solution of the present invention to solve the above technical problems is as follows: a Chinese medicine composition for bidirectionally regulating blood pressure, composed of the following raw materials in parts by weight: 0.2-20 parts of Eucommia ulmoides, 0.12-12 parts of Gastrodia elata, 0.15-15 parts of Lycium barbarum, 0.1-10 parts of Morus alba, 0.12-12 parts of Pueraria lobata, 0.12-12 parts of Cornus officinalis, 0.08-8 parts of Cistanche deserticola, 0.05-0.5 parts of cinnamon bark, 0.15-15 parts of Acanthopanax acanthopanax, 0.15-15 parts of oyster, 0.05-5 parts of Gallnut, 0.08-8 parts of Uncaria rhynchophylla and 0.1-10 parts of Prunella vulgaris.

[0009] Chinese medicine prescription explanation:

[0010] Eucommia ulmoides is the bark of Eucommia ulmoides Oliv., a plant of the Eucommia family. It has the effects of nourishing the liver and kidneys, strengthening the tendons and bones, and calming the fetus. It is mainly used to treat kidney deficiency and various types of low back pain, fetal movement disorder, and habitual abortion.

[0011] Gastrodia elata is the dried tuber of Gastrodia elata Bl., a plant of the Orchidaceae family. It has the effects of calming wind and stopping spasms, calming liver yang, and removing wind and unblocking meridians. It is mainly used to treat liver wind, convulsions, dizziness, headache, numbness of limbs, paralysis of hands and feet, rheumatic pain, etc.

[0012] Wolfberry is the dried mature fruit of Lycium barbarum L., a plant of the Solanaceae family. It tastes sweet and is neutral in nature. It has the effect of nourishing the liver and kidneys, and can treat symptoms such as liver and kidney yin deficiency, soreness of the waist and knees, dizziness, forgetfulness, vertigo, blurred vision and excessive tears, thirst, and spermatorrhea.

[0013] Mulberry fruit is the fruit spike of Morus alba L., a plant of the Moraceae family. It has the effects of nourishing yin and blood, promoting body fluid and moistening the intestines. It is mainly used to treat vertigo and tinnitus, premature graying of hair, amenorrhea due to blood deficiency, thirst due to loss of body fluid, internal heat and thirst, and constipation due to dry intestines.

[0014] Pueraria root is the dried root of Pueraria lobata (Willd.) Ohwi, a plant of the genus Pueraria in the leguminous family. It has the effects of relieving muscles and reducing fever, clearing rashes, promoting fluid and quenching thirst, and raising yang and stopping diarrhea. It is mainly used to treat fever due to superficial symptoms, stiffness and pain in the neck and back, measles that does not clear up, thirst due to febrile disease, polydipsia due to yin deficiency, hot diarrhea and dysentery, and diarrhea due to spleen deficiency.

[0015] Cornus officinalis is the dried mature pulp of Cornus officinalis Sieb.et Zucc., a plant of the Cornaceae family. It has the effects of nourishing the liver and kidneys, and astringing and consolidating. It is mainly used to treat soreness of the waist and knees, dizziness and tinnitus, impotence, spermatorrhea, enuresis and frequent urination, metrorrhagia, excessive menstruation, profuse sweating, and physical weakness.

[0016] Cistanche deserticola is the fleshy stem with scaly leaves of Cistanche deserticola YCMa, a plant of the Orobanchaceae family. It has the effects of nourishing the kidney and yang, moistening the intestines and relieving constipation. It is mainly used to treat kidney yang deficiency, insufficient essence and blood, impotence and premature ejaculation, uterine coldness and infertility, soreness of the waist and knees, flaccidity and weakness, dry intestines and constipation.

[0017] Cinnamon is the dried bark of Cinnamomum cassia Presl, a plant of the Lauraceae family. It has the effects of replenishing fire and yang, dispelling cold and relieving pain, promoting blood circulation and dredge menstruation. It is used for kidney yang deficiency, impotence, cold uterus, dizziness and red eyes, cold pain in the heart and abdomen, cold arthralgia and low back pain, cold hernia and running pig, cold stagnation and blood stasis, amenorrhea, dysmenorrhea, yin carbuncle and flow injection, etc.

[0018] Acanthopanax bark is the dried root bark of Acanthopanar gracilistμlus WWSmith, a plant of the genus Acanthopanax of the family Araliaceae. It has the effects of removing rheumatism, nourishing the liver and kidneys, strengthening the tendons and bones, and promoting diuresis. It is mainly used to treat rheumatic arthralgia, weakness of the tendons and bones, delayed walking in children, physical weakness, edema, and beriberi.

[0019] Oysters are the shells of the long oyster Ostrea gigas Thunb., Dalian Bay oyster O.Tallienwhanensisi Crosse or Omi oyster O.rivularis Gould, which belong to the oyster family. They have the effects of calming the liver and suppressing yang, astringing and consolidating, softening and dispersing nodules, and calming the nerves. They are used to treat restlessness, palpitations and insomnia; hyperactivity of liver yang, dizziness; phlegm nodules, goiters, scrofula, and accumulation of masses; spontaneous sweating, night sweats, spermatorrhea, spermatorrhea, enuresis, frequent urination, metrorrhagia, leucorrhea and other slippery symptoms; stomachache and acid reflux; lily disease; bleeding from trauma; sores, carbuncles, swellings and eczema.

[0020] Gallnut is a gall on the leaves of Rhus chinensis Mill., Rhuspotaninii Maxim. or Rhus punjabensis Stew.var.sinica(Diels)Rehd.et Wils. of the Anacardiaceae family. It is mainly formed by the parasitism of the gallnut aphid Melaphis chinensis(Bell)Baker. It has the effects of astringing the lungs and reducing fire, relieving cough and sweating, astringing the intestines and stopping diarrhea, consolidating semen and stopping nocturnal emission, astringing and stopping bleeding, astringing moisture and astringing sores. It is mainly used to treat cough, hemoptysis, spontaneous sweating, night sweats, chronic diarrhea, chronic dysentery, spermatorrhea, spermatorrhea, metrorrhagia, bloody stool and hemorrhoidal blood, eczema, and swelling and toxins.

[0021] Uncaria rhynchophylla is the dried hooked stems and branches of Uncaria rhynchophylla (Miq.) Miq. ex Havil, Uncaria macrophylla Wall., Uncaria hirsuta Havil., Uncaria sinensis (Oliv.) Havil. or Uncaria sessilifructus Roxb. of the Rubiaceae family; it has the effects of calming wind and relieving convulsions, clearing away heat and soothing the liver; it is often used for internal liver wind movement, epilepsy convulsions, high fever convulsions, colds with convulsions, crying in children, eclampsia during pregnancy, headache and dizziness.

[0022] Prunella vulgaris is the dried fruit spike of Prunella vulgaris L., a plant of the genus Prunella in the family Lamiaceae. It has the effects of clearing away heat and purging fire, improving eyesight, dispersing stagnation and reducing swelling; it is mainly used to treat red and swollen eyes, headache and dizziness, night pain in the eyeballs, scrofula, goiter, and swelling and pain in breast abscess.

[0023] In the prior art, there is no report on the combination of Eucommia ulmoides, Gastrodia elata, Lycium barbarum, Morus alba, Pueraria lobata, Cornus officinalis, Cistanche deserticola, Cinnamon bark, Acanthopanax acanthopanax, Oyster, Gallnut, Uncaria rhynchophylla and Herba Prunellae for bidirectional blood pressure regulation. After a large number of experiments, the inventors of the present application were pleasantly surprised and unexpectedly found that the combination of the above raw materials can achieve the effects of regulating blood pressure, replenishing the kidney and replenishing essence, calming the liver and suppressing yang, and lowering blood pressure and promoting diuresis. In the prescription, Eucommia ulmoides, Gastrodia elata, Uncaria rhynchophylla are monarch drugs; Lycium barbarum, Morus alba, Pueraria lobata, Cornus officinalis, and Cortex acanthopanax are minister drugs; Oyster, Gallnut, Cistanche deserticola are adjuvant drugs; Cinnamon bark and Herba Prunellae are messenger drugs. The monarch, minister, assistant and messenger are mutually compatible, with definite curative effect, and can achieve the technical effects of bidirectional blood pressure regulation and blood pressure stabilization, and there is no recurrence, safety and reliability, and no side effects.

[0024] The beneficial effects of the Chinese medicine composition for bidirectionally regulating blood pressure of the present invention are:

[0025] 1. The Chinese medicine composition for bidirectional regulation of blood pressure of the present invention has the effects of regulating blood pressure, tonifying the kidney and replenishing essence, calming the liver and suppressing yang, lowering blood pressure and promoting diuresis, can achieve the technical effects of bidirectional regulation of blood pressure and blood pressure stabilization, and can be used to prepare drugs for treating bidirectional regulation of blood pressure.

[0026] 2. The Chinese medicine composition for bidirectionally regulating blood pressure of the present invention has no toxic side effects, has a definite therapeutic effect, does not recur after drug withdrawal, is safe and reliable, and has no side effects.

[0027] Based on the above technical solution, the present invention can also be improved as follows.

[0028] Furthermore, it is composed of the following raw materials in parts by weight: 0.4-10 parts of Eucommia ulmoides, 0.24-6 parts of Gastrodia elata, 0.3-7.5 parts of Lycium barbarum, 0.2-5 parts of Morus alba, 0.24-6 parts of Pueraria lobata, 0.24-6 parts of Cornus officinalis, 0.16-4 parts of Cistanche deserticola, 0.1-2.5 parts of cinnamon bark, 0.3-7.5 parts of Acanthopanax acanthopanax, 0.3-7.5 parts of oyster, 0.1-2.5 parts of Gallnut, 0.16-4 parts of Uncaria rhynchophylla and 0.2-5 parts of Prunella vulgaris.

[0029] The further beneficial effect of adopting the above is: the above are the optimal parameters, and the obtained Chinese medicine composition has the best effect.

[0030] Furthermore, it is composed of the following raw materials in parts by weight: 1-4 parts of Eucommia ulmoides, 0.6-2.4 parts of Gastrodia elata, 0.75-3 parts of Lycium barbarum, 0.5-2 parts of Morus alba, 0.6-2.4 parts of Pueraria root, 0.6-2.4 parts of Cornus officinalis, 0.4-1.6 parts of Cistanche deserticola, 0.25-1 parts of cinnamon bark, 0.75-3 parts of Acanthopanax acanthopanax, 0.75-3 parts of oyster, 0.25-1 parts of Gallnut, 0.4-1.6 parts of Uncaria rhynchophylla and 0.5-2 parts of Prunella vulgaris.

[0031] The further beneficial effect of adopting the above is: the above are the optimal parameters, and the obtained Chinese medicine composition has the best effect.

[0032] Furthermore, it is composed of the following raw materials in parts by weight: 2 parts of Eucommia ulmoides, 1.2 parts of Gastrodia elata, 1.5 parts of Lycium barbarum, 1 part of Morus alba, 1.2 parts of Pueraria lobata, 1.2 parts of Cornus officinalis, 0.8 parts of Cistanche deserticola, 0.5 parts of cinnamon bark, 1.5 parts of Acanthopanax acanthopanax, 1.5 parts of oyster, 0.5 parts of Gallnut, 0.8 parts of Uncaria rhynchophylla and 1 part of Prunella vulgaris.

[0033] The further beneficial effect of adopting the above is: the above are the optimal parameters, and the obtained Chinese medicine composition has the best effect.

[0034] The second object of the present invention is to provide a method for preparing the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure.

[0035] The technical solution of the present invention to solve the above technical problem is as follows: The preparation method of the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure comprises the following steps:

[0036] The following raw materials are weighed in parts by weight respectively: 0.2-20 parts of Eucommia ulmoides, 0.12-12 parts of Gastrodia elata, 0.15-15 parts of Lycium barbarum, 0.1-10 parts of Morus alba, 0.12-12 parts of Pueraria root, 0.12-12 parts of Cornus officinalis, 0.08-8 parts of Cistanche deserticola, 0.05-0.5 parts of Cinnamon bark, 0.15-15 parts of Acanthopanax acanthopanax, 0.15-15 parts of Oyster, 0.05-5 parts of Galla chinensis, 0.08-8 parts of Uncaria rhynchophylla and 0.1-10 parts of Prunella vulgaris, and the raw materials are crushed and sieved respectively, and then mixed evenly to obtain the Chinese medicine composition for bidirectionally regulating blood pressure.

[0037] The above raw materials are all qualified Chinese medicine pieces. The above sieving is through 80-100 mesh sieve.

[0038] The beneficial effects of the preparation method of the Chinese medicine composition for bidirectionally regulating blood pressure of the present invention are:

[0039] The preparation method of the Chinese medicine composition for bidirectionally regulating blood pressure of the present invention is simple, easy to operate, low in cost, and suitable for large-scale promotion and application.

[0040] The third object of the present invention is to provide the application of the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure.

[0041] The technical solution of the present invention to solve the above technical problem is as follows: the above Chinese medicine composition for bidirectional regulation of blood pressure is used alone or as an active component in the preparation of a drug for treating bidirectional regulation of blood pressure.

[0042] The beneficial effects of the application of the Chinese medicine composition for bidirectionally regulating blood pressure of the present invention are:

[0043] The above-mentioned Chinese medicine composition for bidirectional regulation of blood pressure can be used alone or as an active component to prepare a drug for treating bidirectional regulation of blood pressure, thus opening up new uses.

[0044] A fourth object of the present invention is to provide a drug for treating bidirectional blood pressure regulation.

[0045] The technical solution of the present invention to solve the above technical problems is as follows: a drug for bidirectionally regulating blood pressure, taking the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure, adding one or more pharmaceutically acceptable excipients, and making it into a decoction, ointment, pills, granules or capsules according to conventional processes.

[0046] The beneficial effects of the bidirectional blood pressure regulating drug of the present invention are:

[0047] The above-mentioned drug for treating bidirectional regulation of blood pressure can be added with pharmaceutically acceptable excipients to prepare various dosage forms of the drug for treating bidirectional regulation of blood pressure, so that patients can use the drug according to their condition.

[0048] Based on the above technical solution, the present invention can also be improved as follows.

[0049] Furthermore, the preparation method of the ointment adopts a water extraction method or an ethanol extraction method, specifically:

[0050] Water extraction method: take the Chinese medicine composition for bidirectional regulation of blood pressure as described above, add water and boil it for 3 times, each time adding water of 10 times, 8 times and 6 times the weight respectively, each time boiling time is 2h, 1.5h and 1h respectively, combine the decoctions, concentrate to obtain a thick extract with a relative density of 1.29-1.35 at 60°C, that is, obtain;

[0051] Ethanol extraction method: Take the Chinese herbal composition for bidirectionally regulating blood pressure as described above, extract it with ethanol at least 3 times, add 8-11 times the weight of ethanol each time, and reflux for at least 2 hours each time, then filter, combine the filtrate, and concentrate to obtain a thick extract with a relative density of 1.29-1.35 at 60°C.

[0052] The above further beneficial effect is that the above water extraction method or ethanol extraction method can be used to prepare ointments, decoctions, pills, granules or capsules. In addition, biological fermentation technology can also be used to prepare decoctions, ointments, pills, granules or capsules.

[0053] Furthermore, the concentration is carried out under reduced pressure, and the temperature of the under reduced pressure concentration is 60°C-70°C and the pressure is 0.07MPa-0.09MPa.

[0054] Furthermore, the volume concentration of the ethanol is 70%, and the reflux time each time is 2h-3h. DETAILED DESCRIPTION

[0055] The principles and features of the present invention are described below, and the examples are only used to explain the present invention and are not used to limit the scope of the present invention. If no specific technology or conditions are specified in the embodiments, the technology or conditions described in the literature in this field or the product instructions are used. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased through regular channels.

[0056] Example 1

[0057] The Chinese medicine composition for bidirectionally regulating blood pressure in this embodiment is composed of the following raw materials by weight: 0.2g of Eucommia ulmoides, 0.12g of Gastrodia elata, 0.15g of Lycium barbarum, 0.1g of Morus alba, 0.12g of Pueraria lobata, 0.12g of Cornus officinalis, 0.08g of Cistanche deserticola, 0.05g of Cinnamon bark, 0.15g of Acanthopanax acanthopanax, 0.15g of Oyster, 0.05g of Gallnut, 0.08g of Uncaria rhynchophylla and 0.1g of Prunella vulgaris.

[0058] The preparation method of the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure comprises the following steps:

[0059] The following raw materials are weighed respectively: 0.2g of Eucommia ulmoides, 0.12g of Gastrodia elata, 0.15g of Lycium barbarum, 0.1g of Morus alba, 0.12g of Pueraria root, 0.12g of Cornus officinalis, 0.08g of Cistanche deserticola, 0.05g of Cinnamon bark, 0.15g of Acanthopanax acanthopanax, 0.15g of Oyster, 0.05g of Gallnut, 0.08g of Uncaria rhynchophylla and 0.1g of Prunella vulgaris, and after crushing and sieving them respectively, they are mixed evenly to obtain the Chinese medicine composition for bidirectionally regulating blood pressure.

[0060] The above-mentioned Chinese medicine composition for bidirectional regulation of blood pressure is used alone or as an active component in the preparation of a medicine for treating bidirectional regulation of blood pressure.

[0061] The bidirectional blood pressure regulating drug of this embodiment is prepared by taking the bidirectional blood pressure regulating Chinese medicine composition as described above, adding one or more pharmaceutically acceptable excipients, and preparing the decoction, paste, pills, granules or capsules according to conventional processes.

[0062] The preparation method of the ointment adopts a water extraction method or an ethanol extraction method, specifically:

[0063] Water extraction method: take the Chinese medicine composition for bidirectional regulation of blood pressure as described above, add water and boil it for 3 times, each time adding water of 10 times, 8 times and 6 times the weight respectively, each time boiling time is 2h, 1.5h and 1h respectively, combine the decoctions, at a temperature of 60℃-70℃, a pressure of 0.07MPa-0.09MPa, and concentrate under reduced pressure to obtain a thick extract with a relative density of 1.29-1.35 at 60℃, that is, obtain;

[0064] Ethanol extraction method: Take the Chinese herbal composition for bidirectionally regulating blood pressure as described above, extract it with ethanol at least 3 times, add 8-11 times the weight of 70% ethanol by volume concentration each time, reflux time for 2h-3h each time, then filter, combine the filtrate, and concentrate under reduced pressure at a temperature of 60℃-70℃ and a pressure of 0.07MPa-0.09MPa to obtain a thick extract with a relative density of 1.29-1.35 at 60℃.

[0065] Example 2

[0066] The Chinese medicine composition for bidirectionally regulating blood pressure in this embodiment is composed of the following raw materials by weight: 0.4g of Eucommia ulmoides, 0.24g of Gastrodia elata, 0.3g of Lycium barbarum, 0.2g of Morus alba, 0.24g of Pueraria lobata, 0.24g of Cornus officinalis, 0.16g of Cistanche deserticola, 0.1g of Cinnamon bark, 0.3g of Acanthopanax acanthopanax, 0.3g of Oyster, 0.1g of Gallnut, 0.16g of Uncaria rhynchophylla and 0.2g of Prunella vulgaris.

[0067] The preparation method of the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure is the same as that in Example 1.

[0068] The above-mentioned Chinese medicine composition for bidirectional regulation of blood pressure is used alone or as an active component in the preparation of a medicine for treating bidirectional regulation of blood pressure.

[0069] The bidirectional blood pressure regulating drug of this embodiment is the same as that of embodiment 1.

[0070] Example 3

[0071] A Chinese medicine composition for bidirectionally regulating blood pressure in this embodiment is composed of the following raw materials by weight: 1g of Eucommia ulmoides, 0.6g of Gastrodia elata, 0.75g of Lycium barbarum, 0.5g of Morus alba, 0.6g of Pueraria lobata, 0.6g of Cornus officinalis, 0.4g of Cistanche deserticola, 0.25g of Cinnamon bark, 0.75g of Acanthopanax acanthopanax, 0.75g of Oyster, 0.25g of Gallnut, 0.4g of Uncaria rhynchophylla and 0.5g of Prunella vulgaris.

[0072] The preparation method of the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure is the same as that in Example 1.

[0073] The above-mentioned Chinese medicine composition for bidirectional regulation of blood pressure is used alone or as an active component in the preparation of a medicine for treating bidirectional regulation of blood pressure.

[0074] The bidirectional blood pressure regulating drug of this embodiment is the same as that of embodiment 1.

[0075] Example 4

[0076] A Chinese medicine composition for bidirectionally regulating blood pressure in this embodiment is composed of the following raw materials by weight: 2g of Eucommia ulmoides, 1.2g of Gastrodia elata, 1.5g of Lycium barbarum, 1g of Morus alba, 1.2g of Pueraria lobata, 1.2g of Cornus officinalis, 0.8g of Cistanche deserticola, 0.5g of Cinnamon bark, 1.5g of Acanthopanax acanthopanax, 1.5g of Oyster, 0.5g of Gallnut, 0.8g of Uncaria rhynchophylla and 1g of Prunella vulgaris.

[0077] The preparation method of the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure is the same as that in Example 1.

[0078] The above-mentioned Chinese medicine composition for bidirectional regulation of blood pressure is used alone or as an active component in the preparation of a medicine for treating bidirectional regulation of blood pressure.

[0079] The bidirectional blood pressure regulating drug of this embodiment is the same as that of embodiment 1.

[0080] Example 5

[0081] A Chinese medicine composition for bidirectionally regulating blood pressure in this embodiment is composed of the following raw materials by weight: 4g of Eucommia ulmoides, 2.4g of Gastrodia elata, 3g of Lycium barbarum, 2g of Morus alba, 2.4g of Pueraria lobata, 2.4g of Cornus officinalis, 1.6g of Cistanche deserticola, 1g of Cinnamon bark, 3g of Acanthopanax acanthopanax, 3g of Oyster, 1g of Gallnut, 1.6g of Uncaria rhynchophylla and 2g of Prunella vulgaris.

[0082] The preparation method of the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure is the same as that in Example 1.

[0083] The above-mentioned Chinese medicine composition for bidirectional regulation of blood pressure is used alone or as an active component in the preparation of a medicine for treating bidirectional regulation of blood pressure.

[0084] The bidirectional blood pressure regulating drug of this embodiment is the same as that of embodiment 1.

[0085] Example 6

[0086] The Chinese medicine composition for bidirectionally regulating blood pressure in this embodiment is composed of the following raw materials by weight: 10g of Eucommia ulmoides, 6g of Gastrodia elata, 7.5g of Lycium barbarum, 5g of Morus alba, 6g of Pueraria lobata, 6g of Cornus officinalis, 4g of Cistanche deserticola, 2.5g of Cinnamon bark, 7.5g of Acanthopanax acanthopanax, 7.5g of Oyster, 2.5g of Gallnut, 4g of Uncaria rhynchophylla and 5g of Prunella vulgaris.

[0087] The preparation method of the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure is the same as that in Example 1.

[0088] The above-mentioned Chinese medicine composition for bidirectional regulation of blood pressure is used alone or as an active component in the preparation of a medicine for treating bidirectional regulation of blood pressure.

[0089] The bidirectional blood pressure regulating drug of this embodiment is the same as that of embodiment 1.

[0090] Example 7

[0091] The Chinese medicine composition for bidirectionally regulating blood pressure in this embodiment is composed of the following raw materials by weight: 20g of Eucommia ulmoides, 12g of Gastrodia elata, 15g of Lycium barbarum, 10g of Morus alba, 12g of Pueraria lobata, 12g of Cornus officinalis, 8g of Cistanche deserticola, 0.5g of Cinnamon bark, 15g of Acanthopanax acanthopanax, 15g of Oyster, 5g of Gallnut, 8g of Uncaria rhynchophylla and 10g of Prunella vulgaris.

[0092] The preparation method of the above-mentioned Chinese medicine composition for bidirectionally regulating blood pressure is the same as that in Example 1.

[0093] The above-mentioned Chinese medicine composition for bidirectional regulation of blood pressure is used alone or as an active component in the preparation of a medicine for treating bidirectional regulation of blood pressure.

[0094] The bidirectional blood pressure regulating drug of this embodiment is the same as that of embodiment 1.

[0095] Test example

[0096] (1) Comparative observation of clinical efficacy in treating hypotension

[0097] The Chinese medicine of the present invention is used in the following clinical situations: 100 patients with hypotension were diagnosed and treated, including 20 males and 80 females. Arterial systolic pressure ≥ 140 mmHg, diastolic pressure ≥ 90 mmHg, that is, hypertension; arterial systolic pressure < 90 mmHg, diastolic pressure < 60 mmHg arterial systolic pressure < 90 mmHg, diastolic pressure < 60 mmHg, that is, hypotension. In the present invention, high pressure is equivalent to the systolic pressure mentioned in daily life, and low pressure is equivalent to the diastolic pressure mentioned in daily life. High pressure ≤ 90 mmHg is high pressure low, low pressure ≤ 60 mmHg is low low pressure, and the normal range of high pressure is greater than 90 mmHg and less than 140 mmHg, and the normal range of low pressure is greater than 60 mmHg and less than 90 mmHg.

[0098] Diagnostic criteria: Refer to the conventional diagnostic criteria for hypotension, blood pressure is lower than 90 / 60 mmHg, accompanied by dizziness, fatigue and chills, and blood routine examination shows normal or slightly lower than normal red blood cells.

[0099] Efficacy standards: Refer to the efficacy standards for hypotension in the "Diagnosis and Efficacy Standards for Traditional Chinese Medicine Diseases and Syndromes" formulated by the State Administration of Traditional Chinese Medicine.

[0100] Clinical control: Recovery: blood pressure returned to above 100 / 70 mmHg and symptoms disappeared.

[0101] Marked effect: Blood pressure returned to above 90 / 60 mmHg and symptoms disappeared.

[0102] Effective: Blood pressure returned to 90 / 60 mmHg and symptoms were significantly alleviated.

[0103] Ineffective: There was no improvement in blood pressure and symptoms after treatment.

[0104] Treatment method: The patients were divided into two groups, each with 50 cases, including 10 males and 40 females. The treatment group took the Chinese medicine preparation described in Example 4 of the present invention, twice a day, for a course of 3 days, for a total of 2 courses; the control group took Shenqi Shengyang Buxue Capsules, orally, 4-6 capsules at a time, 3 times a day.

[0105] Treatment results: The comparison of the therapeutic effects between the two groups is shown in Table 1.

[0106] Table 1 Comparison of the therapeutic effects of the two groups of cases after treatment

[0107] Group Number of cases get well Significant effect efficient invalid Total Effectiveness Treatment Group 50 26 14 10 0 100％ Control group 50 22 13 10 5 90％

[0108] Table 1 shows that the total effective rates of the two groups were 100% and 90% respectively. The chi-square test showed that p < 0.01, and there was a significant difference between the two groups. The treatment group had a better effect than the control group.

[0109] (2) Comparative observation of clinical efficacy in treating hypertension

[0110] The clinical application of the Chinese medicine of the present invention is as follows: 100 patients with hypertension were diagnosed and treated, including 46 females and 54 males.

[0111] Diagnostic criteria: Meet the diagnostic criteria for hypertension in the "Guidelines for the Prevention and Treatment of Hypertension in China" (revised edition in 2018): systolic blood pressure ≥140 mmHg and / or diastolic blood pressure ≥90 mmHg for three blood pressure measurements on different days.

[0112] Efficacy criteria: Blood pressure index: Measure the patient's 24-hour average systolic blood pressure (24hSBP) and 24-hour average diastolic blood pressure (24hDBP) before and after treatment.

[0113] Clinical control:

[0114] Recovery: Blood pressure returns to below 140 / 90 mmHg and symptoms disappear.

[0115] Markedly effective: The patient's 24-hour average diastolic blood pressure decreased by 10 mmHg or more and returned to the normal blood pressure range, or the diastolic blood pressure did not drop to the normal range but decreased by more than 20 mmHg.

[0116] Effective: The patient's 24-hour average diastolic blood pressure decreases by less than 10 mmHg and returns to the normal blood pressure range, or the 24-hour average diastolic blood pressure decreases by 10-19 mmHg and the blood pressure does not drop to the normal range, or the systolic blood pressure decreases by more than 30 mmHg.

[0117] Ineffective: There was no improvement in blood pressure and symptoms after treatment.

[0118] Treatment method: The patients were divided into two groups, each with 50 cases, including 27 males and 23 females. The treatment group took the Chinese medicine preparation described in Example 4 of the present invention, twice a day, for a course of 3 days, for a total of 2 courses; the control group took levamlodipine, orally, 2.5 mg / time, once a day.

[0119] Treatment results: The comparison of the therapeutic effects between the two groups is shown in Table 2.

[0120] Table 2 Comparison of the therapeutic effects of the two groups of cases after treatment

[0121] Group Number of cases get well Significant effect efficient invalid Total Effectiveness Treatment Group 50 30 16 4 0 100％ Control group 50 36 12 2 0 100％

[0122] Table 1 shows that the total effective rate of both groups was 100%. The chi-square test showed that p < 0.01, and there was a significant difference between the two groups, and the treatment group had better efficacy than the control group.

[0123] In summary, the Chinese medicine composition for bidirectional regulation of blood pressure of the present invention has the effects of regulating blood pressure, tonifying the kidney and replenishing essence, calming the liver and suppressing yang, lowering blood pressure and promoting diuresis, can achieve the technical effects of bidirectional regulation of blood pressure and blood pressure stabilization, and can be used to prepare drugs for the treatment of bidirectional regulation of blood pressure.

[0124] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. A Chinese medicine composition for bidirectionally regulating blood pressure, characterized in that: The invention is composed of the following raw materials in parts by weight: 0.2-20 parts of eucommia bark, 0.12-12 parts of gastrodia elata, 0.15-15 parts of wolfberry, 0.1-10 parts of mulberry, 0.12-12 parts of kudzu root, 0.12-12 parts of cornus officinalis, 0.08-8 parts of cistanche, 0.05-0.5 parts of cinnamon bark, 0.15-15 parts of acanthopanax cortex, 0.15-15 parts of oyster, 0.05-5 parts of gallnut, 0.08-8 parts of Uncaria rhynchophylla and 0.1-10 parts of selfheal.

2. The Chinese medicine composition for bidirectionally regulating blood pressure according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 0.4-10 parts of Eucommia ulmoides, 0.24-6 parts of Gastrodia elata, 0.3-7.5 parts of Lycium barbarum, 0.2-5 parts of Morus alba, 0.24-6 parts of Pueraria root, 0.24-6 parts of Cornus officinalis, 0.16-4 parts of Cistanche deserticola, 0.1-2.5 parts of cinnamon bark, 0.3-7.5 parts of Acanthopanax acanthopanax, 0.3-7.5 parts of oyster, 0.1-2.5 parts of Gallnut, 0.16-4 parts of Uncaria rhynchophylla and 0.2-5 parts of Prunella vulgaris.

3. The Chinese medicine composition for bidirectionally regulating blood pressure according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 1-4 parts of Eucommia ulmoides, 0.6-2.4 parts of Gastrodia elata, 0.75-3 parts of Lycium barbarum, 0.5-2 parts of Morus alba, 0.6-2.4 parts of Pueraria root, 0.6-2.4 parts of Cornus officinalis, 0.4-1.6 parts of Cistanche deserticola, 0.25-1 parts of cinnamon bark, 0.75-3 parts of Acanthopanax acanthopanax, 0.75-3 parts of oyster, 0.25-1 parts of Gallnut, 0.4-1.6 parts of Uncaria rhynchophylla and 0.5-2 parts of Prunella vulgaris.

4. The Chinese medicine composition for bidirectionally regulating blood pressure according to claim 1, characterized in that: It is composed of the following raw materials in parts by weight: 2 parts of Eucommia ulmoides, 1.2 parts of Gastrodia elata, 1.5 parts of Lycium barbarum, 1 part of Morus alba, 1.2 parts of Pueraria lobata, 1.2 parts of Cornus officinalis, 0.8 parts of Cistanche deserticola, 0.5 parts of cinnamon bark, 1.5 parts of Acanthopanax acanthopanax, 1.5 parts of oyster, 0.5 parts of Gallnut, 0.8 parts of Uncaria rhynchophylla and 1 part of Prunella vulgaris.

5. A method for preparing the Chinese medicine composition for bidirectionally regulating blood pressure according to any one of claims 1 to 4, characterized in that: The steps include: The following raw materials are weighed in parts by weight respectively: 0.2-20 parts of Eucommia ulmoides, 0.12-12 parts of Gastrodia elata, 0.15-15 parts of Lycium barbarum, 0.1-10 parts of Morus alba, 0.12-12 parts of Pueraria root, 0.12-12 parts of Cornus officinalis, 0.08-8 parts of Cistanche deserticola, 0.05-0.5 parts of Cinnamon bark, 0.15-15 parts of Acanthopanax acanthopanax, 0.15-15 parts of Oyster, 0.05-5 parts of Galla chinensis, 0.08-8 parts of Uncaria rhynchophylla and 0.1-10 parts of Prunella vulgaris, and the raw materials are crushed and sieved respectively, and then mixed evenly to obtain the Chinese medicine composition for bidirectionally regulating blood pressure.

6. Use of the Chinese medicinal composition for bidirectional regulation of blood pressure according to any one of claims 1 to 4 alone or as an active ingredient in the preparation of a drug for treating bidirectional regulation of blood pressure.

7. A drug for bidirectionally regulating blood pressure, characterized in that: Take the Chinese medicine composition for bidirectionally regulating blood pressure as described in any one of claims 1 to 4 above, add one or more pharmaceutically acceptable excipients, and prepare it into a decoction, paste, pills, granules or capsules according to conventional processes.

8. The drug for bidirectionally regulating blood pressure according to claim 7, characterized in that: The preparation method of the ointment adopts a water extraction method or an ethanol extraction method, specifically: Water extraction method: take the Chinese medicine composition for bidirectional regulation of blood pressure as claimed in claim 7, add water and boil it for 3 times, add water 10 times, 8 times and 6 times of weight each time, and boil it for 2 hours, 1.5 hours and 1 hour each time, combine the decoctions, concentrate to obtain a thick extract with a relative density of 1.29-1.35 at 60°C, and obtain; Ethanol extraction method: Take the Chinese medicine composition for bidirectionally regulating blood pressure as described in claim 7, extract it with ethanol at least 3 times, add 8-11 times the weight of ethanol each time, and reflux for at least 2 hours each time, then filter, combine the filtrate, and concentrate to obtain a thick extract with a relative density of 1.29-1.35 at 60°C.

9. The drug for bidirectionally regulating blood pressure according to claim 8, characterized in that: The concentration is performed under reduced pressure, and the temperature of the concentration under reduced pressure is 60° C.-70° C. and the pressure is 0.07 MPa-0.09 MPa.

10. The drug for bidirectionally regulating blood pressure according to claim 8, characterized in that: The volume concentration of the ethanol is 70%, and the reflux time each time is 2h-3h.