Antibacterial catheter

Abstract

The invention relates to an antibacterial catheter which is made of antibacterial plastic, and the antibacterial plastic comprises at least one first plastic matrix, a second plastic matrix or a thermoplastic elastomer material and at least one antibacterial agent. The antibacterial agent comprises metal of molybdenum and / or tungsten, or metal oxide thereof, or molybdenum and / or tungstate, or molybdenum and / or zincate, or polyoxometallate (POM) containing molybdenum and / or tungsten. The antibacterial function of the antibacterial catheter is achieved through a non-contact antibacterial mechanism, toxic and side effects are avoided, and common pathogenic microorganisms and super bacteria can be effectively resisted; the composition is safe and harmless, does not change hereditary characteristics of cells, does not cause carcinogenesis, does not generate drug resistance, and is efficient and lasting in antibiosis.

Description

Technical Field

[0001] The present application relates to the field of antibacterial treatment, and in particular to an antibacterial urinary catheter. Background Art

[0002] Catheterization is one of the basic clinical operations in urology. It is the main means to solve urine retention and a necessary operation after many urology surgeries. It is used to insert the catheter into the bladder through the urethra to drain urine out of the body. After the catheter is inserted into the bladder, in order to fix the catheter in the bladder, a balloon is set near the head of the catheter. Water is injected into the balloon through the water injection channel. After the balloon is inflated by water, it is stuck in the body. Finally, the urine in the bladder is drained out through the drainage channel. The three-lumen catheter has a flushing channel.

[0003] Adverse reactions caused by catheters include bacterial colonization, antibiotic resistance, chronic infection, kidney and bladder damage, kidney stones, bladder pseudopolyps, sepsis, urethral injury, etc. Catheter-associated urinary tract infection refers to urinary tract infection that occurs within 48 hours after the patient has a urinary catheter or has the catheter removed. Catheter-associated urinary tract infection is the most common cause of nosocomial urinary tract infection, accounting for 80% of urinary tract infections. Therefore, catheters with antibacterial properties have great clinical significance.

[0004] JP2001-54320 describes a plastic material containing a mixture of 0.005 to 1 wt % of molybdenum trioxide and silver oxide. The invention relates to a film consisting of an antimicrobial resin component and a component that can be used for a partition material for a clean room, which is used for the outermost layer of floor coverings, pads, briefcases, table mats, tablecloths, packaging bags, textiles, etc. The problem here is that the transparency of the plastic material (for example, vinyl chloride resin) is lost when inorganic, antimicrobial active substances are added. The loss of transparency can be avoided by using a mixture of hexavalent molybdenum oxides. The application has revealed that the antimicrobial effect can no longer be achieved when the weight ratio of molybdenum trioxide to silver oxide exceeds 95:5. Therefore, the antimicrobial effect is essentially not attributable to molybdenum oxide. If the ratio of molybdenum oxide to silver oxide is less than 30:70, that is, a small proportion of molybdenum oxide is contained, the vinyl chloride resin will discolor. JP2001-04022 describes an antimicrobial catheter material, which contains both organic components with antimicrobial effect and metal components. Silver, platinum, copper, zinc, nickel, cobalt, molybdenum and chromium are mentioned as metal components with antibacterial effects. However, in the examples and preferred embodiments, only silver and copper are mentioned as active. Currently, catheters with antibacterial functions on the market are all achieved by coating antibacterial materials or antibacterial drugs on the surface, such as silver coating, antibiotic coating, antibacterial enzyme coating, phage coating, antibacterial peptide coating, etc. However, these methods occasionally have defects such as validity period, drug resistance, stability and production cost, that is, there are defects such as failure in urine environment, short validity period, potential toxicity or drug resistance, so clinical application is greatly limited. Summary of the invention

[0005] The purpose of the present application is to provide an antibacterial urinary catheter, which can inhibit bacteria for a long time and has a bactericidal rate of more than 95%. After 3 months, the bactericidal rate can still reach 90%.

[0006] This application specifically involves the following contents:

[0007] The present application provides an antibacterial urinary catheter, wherein the catheter is made of antibacterial plastic;

[0008] The antimicrobial plastic comprises at least one first plastic matrix, a second plastic matrix or a thermoplastic elastomer material (TPE) and at least one antimicrobial agent;

[0009] The antimicrobial agent comprises molybdenum and / or tungsten metal, or metal oxides thereof, or molybdenum and / or tungstates, or molybdates and zincates, or zincates, or polyoxometalates (POM) containing molybdenum and / or tungsten.

[0010] Furthermore, in the antibacterial plastic, the weight percentage of the antibacterial agent is 0.01-50wt%.

[0011] Furthermore, the antibacterial plastic further comprises an antistatic agent, and the weight percentage of the antistatic agent is 0.01-30wt%.

[0012] Furthermore, in the antibacterial plastic, the weight percentage of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material is 50-99wt%.

[0013] Furthermore, the particle size of the antibacterial agent is 1 nm-100 μm.

[0014] Furthermore, the antistatic agent is one or more of a cationic antistatic agent, an anionic antistatic agent, an amphoteric antistatic agent, a nonionic antistatic agent or a polymer antistatic agent, preferably a nonionic antistatic agent or a polymer antistatic agent;

[0015] Preferably, the nonionic antistatic agent is selected from one or more of ethylene oxide amines, ethoxylated amines, alkyl block polyethers, ethyl sulfate salts, polyethylene oxide, polyethylene glycol esters or ethers, polyol fatty acid esters, fatty acid alkanolamides, fatty amine ethoxylated ethers, glycerol, polyglycerol, sorbitol, polyols, and stearic acid monoglyceride, more preferably alkyl block polyethers or ethoxylated amines.

[0016] Preferably, the polymer antistatic agent is a polyether polymer antistatic agent or an ionic polymer antistatic agent.

[0017] The polyether-type polymer antistatic agent is a polyether / polyolefin block polymer or a polyether compound, wherein the polyether compound is selected from one or more of polyethylene oxide (PEO), polyether ester amide (PEEA), polyether ester imide (PEAI), polyethylene oxide-epichlorohydrin copolymer (PEO-ECH) and polyethylene glycol methacrylic acid copolymer (PEGM), preferably a polyether compound (polyether / polyolefin block polymer), polyether ester amide (PEEA) and polyether ester imide (PEAI) compound;

[0018] The ionic polymer antistatic agent is obtained by introducing small molecule salts into polymer side groups through polymer chemical reaction, and is preferably a quaternary ammonium salt polymer antistatic agent or a sulfonate salt polymer antistatic agent.

[0019] Furthermore, the first plastic matrix is ​​selected from one or more of polypropylene PP, polyethylene PE, polyvinyl chloride PVC, polycarbonate PC, polystyrene PS, polyamide PA, polylactic acid PLA, polyethylene glycol PEG or acrylonitrile-butadiene-styrene copolymer ABS.

[0020] Furthermore, the thermoplastic elastomer material (TPE) is selected from one or more of polyurethane thermoplastic elastomer TPU, styrene thermoplastic elastomer TPS, olefin thermoplastic elastomer TPO, dynamically vulcanized thermoplastic elastomer TPV, polyester thermoplastic elastomer TPEE, and polyamide thermoplastic elastomer TPA.

[0021] Furthermore, the second plastic matrix is ​​selected from one or more of polyacrylamide, polyamide, polyacrylic acid, polysulfonate polyvinyl alcohol, cellulose, starch, polysaccharide, and polyethylene oxide.

[0022] Furthermore, the antibacterial agent includes one or more of molybdenum oxide, tungsten oxide, zinc molybdate, blue tungsten, and POM, preferably zinc molybdate or blue tungsten.

[0023] Furthermore, the valence of the molybdenum element or the tungsten element in the antibacterial agent is +4 to +6.

[0024] Furthermore, through X-ray fluorescence spectrometry (XRF) or X-ray photoelectron spectroscopy (XPS) detection, the plastic contains metal elements of the antibacterial agent.

[0025] Furthermore, the method for preparing the antibacterial plastic comprises the following steps:

[0026] The first plastic matrix, the second plastic matrix or at least one of the thermoplastic elastomer material (TPE) and the antibacterial agent are mixed and directly extruded to obtain the antibacterial plastic, or the first plastic matrix, the second plastic matrix or at least one of the thermoplastic elastomer material and the antibacterial agent are uniformly mixed and kneaded by a mixing process, and then the kneaded raw materials are added to an extruder and extruded, or the first plastic matrix, the second plastic matrix or at least one of the thermoplastic elastomer material and the antibacterial agent are first mixed with the antibacterial agent to prepare a high-concentration antibacterial masterbatch by means of a kneading process, and then at least one of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material is added to dilute it, and then extruded to obtain the antibacterial plastic;

[0027] The antimicrobial agent comprises molybdenum and / or tungsten metal, or metal oxides thereof, or molybdenum and / or tungstates, or molybdates and zincates, or zincates, or polyoxometalates (POM) containing molybdenum and / or tungsten.

[0028] The antibacterial catheter described in the present application utilizes molybdate and / or tungstate produced by the reaction of the antibacterial agent with water molecules, and other byproducts, to reduce the pH value on the surface of the antibacterial catheter. At the same time, the antibacterial agent can produce pentavalent molybdenum ions or tungstate ions, free radicals (such as superoxide and hydroxyl groups), and form a positive Zeta potential on the surface of the antibacterial catheter, thereby achieving a broad-spectrum and efficient anti-pathogenic microbial effect. For example, molybdenum oxide reacts with water to form molybdate (H2MoO4), which then reacts with H2O to form H3O + and MoO4 - or MoO4 2- Tungsten oxide also reacts with H2O to form tungstic acid (H2WO4), which reacts with H2O to form H3O + and WO4 - or WO4 2- .

[0029] Since the antibacterial catheter described in the present application realizes a safe and lasting antibacterial effect by means of a non-contact sterilization mechanism stimulated by a water environment, the entire sterilization process is caused by the antistatic agent added to the antibacterial plastic, and is completed by the weak acid environment and pentavalent molybdenum ions formed on the surface of the antibacterial plastic and the Zeta potential of the plastic surface, so this non-contact sterilization method ensures that the entire sterilization process is safe; furthermore, since the antistatic agent only acts as a catalyst in the sterilization process and is not consumed by itself, a lasting antibacterial and antibacterial effect is achieved. The antibacterial effect of the antibacterial plastic of the present application is realized through a non-contact antibacterial mechanism, has no toxic side effects, and can effectively resist common pathogenic microorganisms and super bacteria; it is safe and harmless, does not change the genetic characteristics of cells, is not carcinogenic, does not produce drug resistance, and has high efficiency and lasting antibacterial properties.

[0030] The antibacterial catheter described in the present application has adverse reactions caused by the catheter, such as bacterial colonization, antibiotic resistance, chronic infection, kidney and bladder damage, kidney stones, bladder pseudopolyps, sepsis, urethral damage, etc. Catheter-associated urinary tract infection refers to a urinary system infection that occurs within 48 hours after the patient has an indwelling catheter or has the catheter removed. Catheter-associated urinary tract infection is the most common cause of nosocomial urinary tract infection, and the incidence rate can account for 80% of urinary tract infections. Therefore, the catheter with durable antibacterial properties of the present application has great clinical significance. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] The accompanying drawings are used to better understand the present application and do not constitute an improper limitation on the present application.

[0032] Figure 1 This is a schematic diagram of the structure of the antibacterial urinary catheter disclosed in this application. DETAILED DESCRIPTION

[0033] The present application will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present application and are not used to limit the scope of the present application. In addition, it should be understood that after reading the content of the present application, those skilled in the art can make various changes or modifications to the present application, and these equivalent forms also fall within the scope limited by the claims attached to the present application.

[0034] Scientific research has found that transition metal oxides and their salts, in the presence of water, will catalyze the production of H3O + , forming a weak acid microenvironment; the reaction also generates free radicals (such as superoxide and hydroxyl) and positive Zeta potential. The applicant unexpectedly found that the surface of the antibacterial plastic prepared by adding antibacterial agent, antistatic agent and plastic in a specific ratio has a weak acid microenvironment. Under the synergistic effect of the antibacterial mechanism, it has the advantages of being able to quickly kill and permanently inhibit pathogenic microorganisms (bacteria, viruses and molds) and multi-drug resistant bacteria, with rapid effect and long-lasting antibacterial effect, and the antibacterial agent itself is difficult to be absorbed by the human body and does not produce toxic side effects.

[0035] The specific plan is as follows:

[0036] In the present application, the antistatic agent can also serve as a hydrophilic agent.

[0037] In the present application, the second plastic matrix can also be used as a hydrophilic agent. The antibacterial plastic can be composed of a second plastic matrix and an antibacterial agent.

[0038] The present application provides an antibacterial urinary catheter, which is made of antibacterial plastic, wherein the antibacterial plastic includes at least one first plastic matrix, a second plastic matrix or a thermoplastic elastomer material, and at least one antibacterial agent;

[0039] The antibacterial agent includes molybdenum and / or tungsten metal, or metal oxides thereof (wherein the valence of molybdenum or tungsten is +4 to +6), or molybdenum and / or tungstate, or molybdenum zinc oxide (wherein the valence of molybdenum is +4 to +6), or tungsten zinc oxide (wherein the valence of tungsten is +4 to +6), or molybdenum and / or zincate (wherein the valence of molybdenum is +4 to +6), or polyoxometalate (POM) containing molybdenum and / or tungsten, and the above substances can be used in combination with at least another oxide or salt. Another oxide or salt includes, but is not limited to, zinc oxide, aluminum oxide, silicon dioxide, zirconium oxide, tungsten oxide, titanium oxide, zinc molybdate, etc. The compounding method can be mixing, dispersing, stirring, etc.

[0040] Specifically, the antibacterial agent is selected from one or more of molybdenum trioxide, tungsten trioxide, zinc molybdate, blue tungsten, and tungsten molybdate, preferably molybdenum trioxide, zinc molybdate, blue tungsten, or tungsten molybdate.

[0041] In some embodiments, the antimicrobial agent is molybdenum oxide.

[0042] In some embodiments, the antimicrobial agent is tungsten oxide.

[0043] In some embodiments, the antimicrobial agents are molybdenum oxide and tungsten oxide.

[0044] In some embodiments, the antimicrobial agent is zinc molybdate.

[0045] In some embodiments, the antimicrobial agent is tungstate molybdate.

[0046] In some embodiments, the antimicrobial agent is blue tungsten.

[0047] In some embodiments, the antimicrobial agents are blue tungsten and zinc molybdate.

[0048] In the present application, in the antibacterial plastic, the weight percentage of the antibacterial agent is 0.01-50wt%.

[0049] Specifically, the weight percentage of the antibacterial agent can be 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%, 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt%, 0.1wt%, 0.5wt%, 1wt%, 1.5wt%, 2wt%, 2.5wt%, 3wt%, 3.5wt%, 4wt%, 4.5wt%, 5wt%, 5.5wt%, 6wt%, 6.5wt%, 7wt%, 7.5wt%, 8wt%, 8.5wt%, 9wt%, 9.5wt%, 10wt%, 11wt%, 12wt% %, 13wt%, 14wt%, 15wt%, 16wt%, 17wt%, 18wt%, 19wt%, 20wt%, 21wt%, 22wt%, 23wt%, 24wt%, 25wt%, 26wt%, 27wt%, 28wt%, 29wt%, 30wt%, 31wt%, 32wt%, 33wt%, 34wt%, 35wt%, 36wt%, 37wt%, 38wt%, 39wt%, 40wt%, 41wt%, 42wt%, 43wt%, 44wt%, 45wt%, 46wt%, 47wt%, 48wt%, 49wt% or 50wt%.

[0050] In some embodiments, the weight percentage of the antibacterial agent may be 0.1-50 wt %.

[0051] In some embodiments, the weight percentage of the antibacterial agent may be 0.3-30wt%;

[0052] In some embodiments, the weight percentage of the antibacterial agent may be 0.8-20 wt %.

[0053] In some embodiments, the weight percentage of the antibacterial agent may be 0.8-10 wt %.

[0054] In some embodiments, the weight percentage of the antibacterial agent may be 1-5 wt %.

[0055] In some embodiments, the weight percentage of the antibacterial agent may be 1 wt %.

[0056] In some embodiments, the antibacterial agent is blue tungsten, and its weight percentage can be 0.05-10wt%.

[0057] In some embodiments, the antibacterial agent is blue tungsten, and its weight percentage may be 0.1-2 wt %.

[0058] In some embodiments, the antibacterial agent is blue tungsten, and its weight percentage may be 0.3-0.7 wt %.

[0059] In some embodiments, the antibacterial agent is zinc molybdate, and its weight percentage can be 0.8-20wt%.

[0060] In some embodiments, the antibacterial agent is zinc molybdate, and its weight percentage may be 0.8-10wt%.

[0061] In some embodiments, the antibacterial agent is zinc molybdate, and its weight percentage may be 1-5wt%.

[0062] In some embodiments, the antibacterial agent is zinc molybdate, and its weight percentage may be 1 wt %.

[0063] In the present application, the antibacterial plastic further comprises an antistatic agent, and the weight percentage of the antistatic agent is 0.01-30wt%.

[0064] Specifically, the weight percentage of the antistatic agent can be 0.01wt%, 0.05wt%, 0.1wt%, 0.5wt%, 1wt%, 1.5wt%, 2wt%, 2.5wt%, 3wt%, 3.5wt%, 4wt%, 4.5wt%, 5wt%, 5.5wt%, 6wt%, 6.5wt%, 7wt%, 7.5wt%, 8wt%, 8.5wt%, 9wt%, 9.5wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt%, 15wt%, 16wt%, 17wt%, 18wt%, 19wt%, 20wt%, 21wt%, 22wt%, 23wt%, 24wt%, 25wt%, 26wt%, 27wt%, 28wt%, 29wt% or 30wt%.

[0065] In some embodiments, the weight percentage of the antistatic agent is 0.05-20 wt %.

[0066] In some embodiments, the weight percentage of the antistatic agent is 0.1-15 wt %.

[0067] In some embodiments, the weight percentage of the antistatic agent is 0.5-10 wt %.

[0068] In some embodiments, the weight percentage of the antistatic agent is 3 wt %.

[0069] In the present application, in the antibacterial plastic, the weight percentage of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material is 50-99wt%.

[0070] Specifically, the weight percentage of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material can be 50wt%, 51wt%, 52wt%, 53wt%, 54wt%, 55wt%, 56wt%, 57wt%, 58wt%, 59wt%, 60wt%, 61wt%, 62wt%, 63wt%, 64wt%, 65wt%, 66wt%, 67wt%, 68wt%, 69wt%, 70wt%, 71wt%, 72wt%, 73wt%, 74wt%, 75wt%, 76wt%, 77wt%, 78wt%, 79wt%, 80wt%, 81wt%, 82wt%, 83wt%, 84wt%, 85wt%, 86wt%, 87wt%, 88wt%, 89wt%, 90wt%, 91wt%, 92wt%, 93wt%, 94wt%, 95wt%, 96wt%, 97wt%, 98wt%, 99wt%, 100wt%, 101wt%, 102wt%, 103wt%, 104wt%, 105wt%, 106wt%, 107wt%, 108wt%, 109wt%, 110 72wt%, 73wt%, 74wt%, 75wt%, 76wt%, 77wt%, 78wt%, 79wt%, 80wt%, 81wt%, 82wt%, 83wt%, 84wt%, 85wt%, 86wt%, 87wt%, 88wt%, 89wt%, 90wt%, 91wt%, 92wt%, 93wt%, 94wt%, 95wt%, 96wt%, 97wt%, 98wt% or 99wt%.

[0071] In some embodiments, the weight percentage of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material is 60-98 wt %.

[0072] In some embodiments, the weight percentage of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material is 70-97 wt %.

[0073] In some embodiments, the weight percentage of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material is 80-95 wt %.

[0074] In some embodiments, the weight percentage of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material is 95 wt %.

[0075] In the present application, the antibacterial agent is in the form of solid powder, and the particle size of the antibacterial agent is 1 nm-100 μm, preferably 1 μm-5 μm.

[0076] In some embodiments, the particle size of the antibacterial agent is 1 μm-10 μm.

[0077] In some embodiments, the particle size of the antibacterial agent is 1 μm-20 μm.

[0078] In some embodiments, the particle size of the antibacterial agent is 1 μm-30 μm.

[0079] In some embodiments, the particle size of the antibacterial agent is 1 μm-40 μm.

[0080] In some embodiments, the particle size of the antibacterial agent is 1 μm-50 μm.

[0081] In some embodiments, the particle size of the antibacterial agent is 1 μm-60 μm.

[0082] In some embodiments, the particle size of the antibacterial agent is 1 μm-70 μm.

[0083] In some embodiments, the particle size of the antibacterial agent is 1 μm-80 μm.

[0084] In some embodiments, the particle size of the antibacterial agent is 1 μm-90 μm.

[0085] In some embodiments, the particle size of the antibacterial agent is 1 μm-100 μm.

[0086] Specifically, the particle size of the antibacterial agent can be 1nm, 5nm, 10nm, 15nm, 20nm, 25nm, 30nm, 35nm, 40nm, 45nm, 50nm, 55nm, 60nm, 65nm, 70nm, 75nm, 80nm, 85nm, 90nm, 95nm, 100nm, 110nm, 120nm, 130nm, 140nm, 150nm, 160nm, 170nm, 180nm, 190nm, 200nm, 250nm m, 300nm, 350nm, 400nm, 450nm, 500nm, 550nm, 600nm, 650nm, 700nm, 750nm, 800nm, 850nm, 900nm, 1μm, 5μm, 10μm , 15μm, 20μm, 25μm, 30μm, 35μm, 40μm, 45μm, 50μm, 55μm, 60μm, 65μm, 70μm, 75μm, 80μm, 85μm, 90μm, 95μm or 100μm.

[0087] In some embodiments, the antibacterial agent is zinc molybdate, and its particle size is 1 nm-100 μm.

[0088] In some embodiments, the antibacterial agent is zinc molybdate, and its particle size is 1 μm-5 μm.

[0089] In some embodiments, the antibacterial agent is zinc molybdate, and its particle size is 1 μm-20 μm.

[0090] In some embodiments, the antibacterial agent is zinc molybdate, and its particle size is 1 μm-40 μm.

[0091] In some embodiments, the antibacterial agent is zinc molybdate, and its particle size is 1 μm-60 μm.

[0092] In some embodiments, the antibacterial agent is zinc molybdate, and its particle size is 1 μm-80 μm.

[0093] In some embodiments, the antibacterial agent is blue tungsten, and its particle size is 1 nm-99 nm.

[0094] In some embodiments, the antibacterial agent is blue tungsten, and its particle size is 2nm-50nm.

[0095] In some embodiments, the antibacterial agent is blue tungsten, and its particle size is 2nm-60nm.

[0096] In some embodiments, the antibacterial agent is blue tungsten, and its particle size is 2nm-70nm.

[0097] In some embodiments, the antibacterial agent is blue tungsten, and its particle size is 2nm-80nm.

[0098] In this application, the particle size refers to the D50 particle size, also known as the average particle size. The specific particle size test method is electron microscopy or laser method.

[0099] In the present application, the antistatic agent is one or more of a cationic antistatic agent, an anionic antistatic agent, an amphoteric antistatic agent, a nonionic antistatic agent or a polymer antistatic agent, preferably a nonionic antistatic agent or a polymer antistatic agent.

[0100] Specifically, the nonionic antistatic agent can be one or more of ethylene oxide amines, ethoxylated amines, alkyl block polyethers, ethyl sulfates, polyethylene oxide, polyethylene glycol esters or ethers, polyol fatty acid esters, fatty acid alkanolamides, fatty amine ethoxylated ethers, glycerol, polyglycerol, sorbitol, polyols, stearic acid monoglycerides, and polyethylene oxide, preferably alkyl block polyethers or ethoxylated amines.

[0101] Specifically, the polymer antistatic agent is a polyether polymer antistatic agent and an ionic polymer antistatic agent.

[0102] The polyether polymer antistatic agent can be one or more of polyether / polyolefin block polymers, polyethylene oxide (PEO), polyether ester amide (PEEA), polyether ester imide (PEAI), polyethylene oxide-epichlorohydrin copolymer (PEO-ECH), polyethylene glycol methacrylic acid copolymer (PEGM), preferably polyether compounds (polyether / polyolefin block polymers), polyether ester amide (PEEA) and polyether ester imide (PEAI) compounds.

[0103] Specifically, the ionic polymer antistatic agent is obtained by introducing small molecule salts into polymer side groups through polymer chemical reactions, such as quaternary ammonium salt polymer antistatic agents or sulfonate polymer antistatic agents. For example: (meth) acrylate copolymers containing quaternary ammonium salts and organosilicon containing hydrophilic groups.

[0104] In the present application, the first plastic matrix is ​​selected from one or more of polypropylene PP, polyethylene PE, polyvinyl chloride PVC, polycarbonate PC or acrylonitrile-butadiene-styrene copolymer ABS, including but not limited to them.

[0105] In some embodiments, the first plastic matrix is ​​polypropylene PP.

[0106] In some embodiments, the first plastic matrix is ​​polyethylene PE.

[0107] In the present application, the second plastic matrix is ​​a plastic matrix having a hydrophilic or water-absorbing function.

[0108] The second plastic matrix is ​​selected from one or more of polyacrylamide, polyamide, polyacrylic acid, polysulfonate polyvinyl alcohol, cellulose, starch, polysaccharide, and polyethylene oxide, including but not limited to these.

[0109] In some embodiments, the second plastic matrix is ​​polyamide PA12.

[0110] In the present application, the thermoplastic elastomer material is selected from one or more of polyurethane thermoplastic elastomer TPU, styrene thermoplastic elastomer TPS, olefin thermoplastic elastomer TPO, dynamically vulcanized thermoplastic elastomer TPV, polyester thermoplastic elastomer TPEE, and polyamide thermoplastic elastomer TPA, including but not limited to these.

[0111] In some embodiments, the thermoplastic elastomer material is polyurethane TPU.

[0112] In some embodiments, the thermoplastic elastomer material is thermoplastic elastomer TPEE.

[0113] In some embodiments, the antimicrobial plastic is composed of a first plastic matrix, an antimicrobial agent, and an antistatic agent.

[0114] In some embodiments, the antimicrobial plastic is composed of 50-99 wt % of a first plastic matrix, 0.01-50 wt % of an antimicrobial agent, and 0.01-30 wt % of an antistatic agent.

[0115] In some embodiments, the antimicrobial plastic is composed of a second plastic matrix, an antimicrobial agent, and an antistatic agent.

[0116] In some embodiments, the antimicrobial plastic is composed of 50-99 wt % of the second plastic matrix, 0.01-50 wt % of the antimicrobial agent, and 0.01-30 wt % of the antistatic agent.

[0117] In some embodiments, the antimicrobial plastic is composed of a thermoplastic elastomer material, an antimicrobial agent, and an antistatic agent.

[0118] In some embodiments, the antibacterial plastic comprises 50-99 wt % of thermoplastic elastomer material, 0.01-50 wt % of antibacterial agent, and 0.01-30 wt % of antistatic agent.

[0119] During the molding process of the antibacterial plastic, a nonionic antistatic agent of sufficient concentration is added. When the mixture is in a molten state, the antistatic agent molecules form the densest oriented arrangement at the interface between the resin and the air or between the resin and the metal, wherein the lipophilic groups extend to the inside of the resin and the hydrophilic groups extend to the outside of the resin. After the resin is solidified, the hydrophilic groups on the antistatic agent molecules are all arranged toward the air side to form a monomolecular hydrophilic conductive layer. Thus, the hydrophilic effect of the surface of the antibacterial plastic can be achieved.

[0120] During the molding process of the antibacterial plastic, a polymer antistatic agent of sufficient concentration is added through a mixing process to form a conductive, fine, rib-like layered dispersion structure on the plastic surface, while the central part is nearly spherical. The hydrophilic groups in the molecular chain of the polymer antistatic agent can bind to water in the air, so that a hydrophilic conductive layer is formed on the plastic surface; due to the strong mobility of its molecular chain, it is easy for protons to move between molecules, and static electricity is generated through ion conduction and release. On the other hand, its antistatic ability is manifested in its special dispersed form. Therefore, it does not completely rely on the surface water absorption rate, so it is less affected by the environmental humidity. Its antistatic effect is long-lasting, has no induction period, and is not affected by conditions such as wiping and washing.

[0121] As mentioned above, transition metal oxides and their salts, in the presence of water, will catalyze the production of H3O + , forming a weak acid microenvironment; the reaction also generates free radicals (such as superoxide and hydroxyl) and positive Zeta potential. The antibacterial plastic prepared by the antibacterial agent, antistatic agent and plastic in a specific ratio forms a weak acid microenvironment, free radicals and positive Zeta potential on its surface. Under the synergistic effect of multiple antibacterial mechanisms, it has the advantages of rapid killing and lasting inhibition of pathogenic microorganisms (bacteria, viruses and molds) and multi-drug resistant bacteria, fast effect, long-lasting antibacterial effect, and the antibacterial agent itself is difficult to be absorbed by the human body and does not produce toxic side effects.

[0122] In the present application, the plastic contains the metal element of the antimicrobial agent by X-ray fluorescence spectrometry (XRF) or X-ray photoelectron spectroscopy (XPS).

[0123] The present application provides a method for preparing an antibacterial plastic, wherein a first plastic matrix, a second plastic matrix or at least one of a thermoplastic elastomer material (TPE) and an antibacterial agent are mixed and then directly extruded to obtain the antibacterial plastic, or a mixing process is adopted to firstly mix and uniformly knead the first plastic matrix, the second plastic matrix or at least one of a thermoplastic elastomer material and an antibacterial agent, and then add the kneaded raw materials into an extruder and extrude them, or by means of a kneading process, firstly mix the first plastic matrix, the second plastic matrix or at least one of a thermoplastic elastomer material and an antibacterial agent to form a high-concentration antibacterial masterbatch, and then add at least one of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material to dilute it, and then extrude it to obtain the antibacterial plastic.

[0124] The present application provides a method for preparing an antibacterial plastic, comprising mixing a first plastic matrix, a second plastic matrix or at least one of a thermoplastic elastomer material, an antibacterial agent and an antistatic agent, and then directly extruding the mixture to obtain the antibacterial plastic; or mixing the second plastic matrix and the antibacterial agent, and then extruding the mixture through an extrusion device to obtain the antibacterial plastic; or adopting a mixing process, first uniformly mixing the first plastic matrix or thermoplastic elastomer material, the antibacterial agent and the antistatic agent according to the actual product formula ratio, and then extruding the mixed raw materials through an extrusion device to obtain the antibacterial plastic after a banburying process, or using a banburying process, first mixing the first plastic matrix or thermoplastic elastomer material, the antibacterial agent and the antistatic agent to prepare a high-concentration antibacterial masterbatch, and then adding the first plastic matrix or thermoplastic elastomer material, diluting the mixture, and then extruding the mixture to obtain the antibacterial plastic.

[0125] This application provides three methods for preparing the antibacterial plastic as described above:

[0126] 1) Produce AnbaTec TPU or TPE antimicrobial plastics by mixing or kneading plastic matrix / thermoplastic elastomer material, antimicrobial agent and antistatic agent into the resin. This process is completed with the help of internal mixers, melt extrusion and pelletizing equipment. It is suitable for elastic thermoplastic elastomers such as TPU, TPE, etc. This method can also prepare high-concentration antimicrobial masterbatches.

[0127] 2) Produce AnbaTec PP, PE, PVC antimicrobial plastics by directly mixing the antimicrobial agent, antistatic agent and the first plastic matrix / thermoplastic elastomer material, and extruding or injection molding with standard equipment. Suitable for plastics (plastic matrices) with no elasticity, such as PP, PE, PC, etc.

[0128] 3) AnbaTec antimicrobial plastics are produced by directly mixing the antimicrobial agent with the second plastic matrix / thermoplastic elastomer material and extruding or injection molding using standard equipment.

[0129] Additional additives such as antioxidants, mold release agents, color stabilizers and radiopaque agents (eg barium sulfate) can also be added to AnbaTec antimicrobial plastics.

[0130] Mixing treatment: bake the TPU resin of the weight portion at 85-90°C for 1.0-2.0 hours, heat the mixer to 110-130°C, first add TPU resin and antistatic agent into the mixer for stirring, the amount introduced is 50% of the capacity of the mixer, heat to the surface of the TPU resin to produce a molten state, add the antibacterial agent, cover with a dust cover, continue stirring and heating until the color powder and TPU resin are completely dissolved together, sweep the color powder into the groove edge, press down the hammer and heat to 195-215°C. During the entire mixing process, the rotation speed of the left and right rotor shafts will change in the same direction and reverse direction every 5 minutes, which are 20 rpm and 15 rpm, 15 rpm and 10 rpm, 26 rpm and 20 rpm, respectively, so as to play a better shear mixing effect on the preliminarily mixed rubber, while improving work efficiency and reducing production energy consumption. The mixing process lasts for 20-30 minutes, stop heating, turn on the cooling water, stir for 8-12 minutes, take the material for inspection and dispersion. If it is well dispersed, immediately unload, cut into pieces and cool. If it is not well dispersed, continue to cool and stir for 5 minutes before unloading.

[0131] Extrusion molding treatment: The mixed material after banburying is introduced into an extruder with a preheating temperature of 185℃~215℃, and the speed is controlled at 350~380r / min. After heating, melting and extrusion, the polymer melt is extruded and pelletized through a 0.3cm die hole, and then cooled to 60℃ and dried to obtain an antibacterial base material. For the processing of plastic raw materials without elasticity, the resin, antibacterial agent, antistatic agent and other additives can be directly extruded through a twin-screw extruder after dry mixing.

[0132] The antibacterial plastic prepared by the preparation method described in the present application is the aforementioned antibacterial plastic, and the specific content can refer to the description of the aforementioned antibacterial plastic.

[0133] In the present application, molybdic acid and / or tungstic acid generated by the reaction of the antibacterial agent with water molecules in the air is used to reduce the pH value of the skin at the lesion in contact with the antibacterial plastic. At the same time, the antibacterial agent in the antibacterial plastic can generate free radicals (such as superoxide and hydroxyl) and positive Zeta potential. The above mechanism can produce a synergistic effect, thereby achieving a broad-spectrum and efficient anti-pathogenic microbial effect. For example, molybdenum oxide reacts with water to form molybdic acid (H2MoO4), which then reacts with H2O to form H3O + and MoO4 -or MoO4 2- Tungsten oxide also reacts with H2O to form tungstic acid (H2WO4), which reacts with H2O to form H3O + and WO4 - or WO4 2- .

[0134] The antibacterial plastic of the present application is non-contact antibacterial, has no toxic side effects, and is effective against common pathogenic microorganisms and super bacteria; it is safe and harmless, does not change the genetic characteristics of cells, is not carcinogenic, does not produce drug resistance, and is highly effective and long-lasting in antibacterial properties; the present application has a wide range of potential uses and can be applied to medical devices, sanitary appliances and other auxiliary care products as well as daily hygiene products.

[0135] The structure of the antibacterial urinary catheter described in the present application is a conventional urinary catheter structure, for example, the urinary catheter can be divided into a single cavity, a double cavity and a triple cavity, with one or more drainage holes at the front end, a fixed balloon at the front end of the double cavity and the triple cavity, and a flushing hole at the three cavity. When in use, it is used to be inserted into the bladder through the urethra so as to drain urine to the outside of the body. After the urinary catheter is inserted into the bladder, in order to fix the urinary catheter in the bladder, a balloon is arranged near the head end of the urinary catheter, and water is injected into the balloon through the water injection channel. After the balloon is expanded by water injection, it is stuck in the body, and finally the urine in the bladder is drawn out through the drainage channel. The triple cavity tube has a flushing channel.

[0136] The antibacterial urinary catheter described in the present application can be made into a structure of any shape and size.

[0137] In one embodiment of the present application, the preparation process of the urinary catheter is as follows:

[0138] Catheter tube: After the antibacterial material described in the present application is dried, the tube is extruded through a multi-cavity extrusion die by a melt extruder, and then stretched into the required specifications (outer diameter, shape and size of each cavity) of the catheter raw material by setting a stretching ratio, and then cooled for use. Y-shaped connector: After the antibacterial material is dried, it is injected into the cavity mold by an injection molding machine for injection molding.

[0139] Bonding of tapered fittings to pipes: Use special tooling to locate each cavity of the pipe and bond with glue.

[0140] Head forming: Use a special end forming machine with molds of various specifications to form the head end.

[0141] Punching of flushing and drainage holes: Use a special forming machine with a special forming tool to punch holes, connect the balloon holes with the balloon cavities, connect the drainage holes with the drainage cavities, and connect the flushing holes with the flushing cavities.

[0142] Balloon bonding: The formed balloon is inserted into the front end of the catheter and bonded to the tube, and the balloon cavity of the tube is connected to the balloon.

[0143] Check valve installation: Install the check valve into the balloon cavity end of the tapered connector and secure the seal with adhesive.

[0144] Printing: Pad printer prints specification marks.

[0145] Example

[0146] The experimental methods used in the following examples are all conventional methods unless otherwise specified.

[0147] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0148] TPU resin HF-1195A is produced by Zhejiang Huafeng Company;

[0149] PP resin T30S is produced by Dalian Petrochemical Company;

[0150] PE resin LLDE-7042 is produced by Sinopec Maoming Company;

[0151] TRF-6514 resin was purchased from Shandong Tairuifeng New Materials Co., Ltd.;

[0152] PA12 is produced by Arkema in France. PA12 is a hydrophilic or water-absorbing plastic matrix;

[0153] Zinc molybdate was purchased from Alibaba 1688 Industrial Products Network;

[0154] Tungsten oxide was purchased from Alibaba 1688 Industrial Products Network;

[0155] Tungsten zinc oxide was purchased from Alibaba 1688 Industrial Products Network;

[0156] Blue tungsten was purchased from Alibaba 1688 Industrial Products Network;

[0157] JL-WT6 was purchased from Shandong Juli Antistatic Technology Co., Ltd. JL-WT6 is a non-ionic antistatic agent (ethyl sulfate salt);

[0158] SAS93 was purchased from Alibaba 1688 Industrial Products Network. SAS93 is a non-ionic antistatic agent (ethylene oxide amine type);

[0159] P18 is produced by BASF and is a polymer antistatic agent (polyether / polyolefin block polymer);

[0160] PVL is produced by Sanyo Chemical Co., Ltd. PVL is a polymer antistatic agent (polyether / polyolefin block polymer);

[0161] Example 1

[0162] TPU antibacterial plastic (HF-1195A+JL-WT6+molybdenum oxide)

[0163] In this embodiment, the thermoplastic elastomer is TPU resin HF-1195A. 93wt% of HF-1195A, 2wt% of molybdenum oxide with a particle size of 1μm, and 5wt% of non-ionic antistatic agent JL-WT6 (ethyl sulfate salt) are mixed evenly, mixed, and then extruded through an extrusion device.

[0164] The antibacterial performance data obtained by testing according to GBT31402-2015 standard show that the antibacterial rate of the TPU antibacterial plastic against Escherichia coli is greater than 96.9%, and the antibacterial rate against Staphylococcus aureus is 95.3%. The antibacterial rates after being placed for 6 months are 95.0% and 94.8%, respectively. Details of various parameters are shown in Table 1.

[0165] The antibacterial plastics of Examples 2 to 5 differ from the antibacterial plastic of Example 1 only in the type of antibacterial agent, and their parameters are shown in Table 1.

[0166] The antibacterial plastics of Examples 6 to 8 differ from the antibacterial plastic of Example 2 only in the type of antistatic agent, and their parameters are shown in Table 1.

[0167] The antibacterial plastics of Examples 9 to 12 are different from the antibacterial plastic of Example 2 only in the particle size of the antibacterial agent. The parameters thereof are shown in Table 1.

[0168] The antibacterial plastics of Examples 13 and 14 are different from the antibacterial plastics of Example 3 only in the particle size of the antibacterial agent, and their various parameters are shown in Table 1.

[0169] The antibacterial plastics of Examples 15 and 16 are different from those of Example 2 only in the contents of resin, antibacterial agent and antistatic agent. The parameters thereof are shown in Table 1.

[0170] The antibacterial plastic of Example 17 is different from that of Example 14 only in the contents of resin, antibacterial agent and antistatic agent. The parameters thereof are shown in Table 1.

[0171] Embodiment 18

[0172] TPE antibacterial plastic (TRF-6514+P18+zinc molybdate)

[0173] In this embodiment, the thermoplastic elastomer TPE resin is TRF-6514. Take 93wt% of the resin TRF-6514 and 2wt% of zinc molybdate with a particle size of 1μm, add 5wt% of the polymer antistatic agent P18 (polyether / polyolefin block polymer) and mix them evenly, then bake the TPU resin (TRF-6514) at 85-90℃ for 1.0 hour according to the above weight proportions, heat the mixer to 120℃, first add the TPE resin to the mixer and stir, the amount introduced is 50% of the capacity of the mixer, heat to the surface of the TPE resin to produce a molten state, add the antibacterial agent, cover with a dust cover, continue stirring and heating until the color powder and the TPE resin are completely dissolved together, add the antistatic agent, press down the weight and heat to 200℃. During the whole mixing process, the speed of the left and right rotor shafts will change in the same direction and reverse direction every 5 minutes, which are 20 rpm and 15 rpm, 15 rpm and 10 rpm, 26 rpm and 20 rpm, respectively, so as to better shear and mix the preliminarily mixed rubber, improve work efficiency and reduce production energy consumption. The mixing process lasts for 20-30 minutes, stop heating, turn on the cooling water, stir for 8-12 minutes, take the material for inspection and dispersion, if it is well dispersed, immediately unload the material, cut into pieces and cool, if it is not well dispersed, continue to cool and stir for 5 minutes to unload. Extrusion molding process: The mixed material after mixing is introduced into an extruder with a preheating temperature of 200℃, the speed is controlled at 300-320r / min, and after step heating (180℃, 195℃, 210℃), melting and extrusion, the polymer melt is extruded and pelletized from a 0.3cm die hole, and then cooled to 60 degrees to obtain TPE antibacterial plastic. The detailed parameters of the TPE antibacterial plastic are shown in Table 1.

[0174] Embodiment 19

[0175] PA antibacterial plastic (PA12+zinc molybdate)

[0176] In this embodiment, the second plastic matrix is ​​polyamide resin PA12. 98 wt% of PA12 and 2 wt% of molybdenum oxide with a particle size of 2 μm are mixed evenly and then directly extruded through an extrusion device to form the mixture.

[0177] The antibacterial performance data obtained by testing according to GB / T31402-2015 standard show that the antibacterial rates of the PA antibacterial plastic against Escherichia coli and Staphylococcus aureus are both greater than 99.9%, and the antibacterial rates after being placed for 6 months are 99.4% and 99.2%, respectively. Details of various parameters are shown in Table 1.

[0178] Comparative Example 1

[0179] Antibacterial plastic (TRF-6514 + silver ion antibacterial agent SILVER 350)

[0180] The silver ion powder SILVER 350 produced by Japan Oasis Co., Ltd. and TRF-6514 are mixed and stirred uniformly, and the antibacterial plastic is obtained by direct extrusion. The weight percentage of the silver ion antibacterial agent SILVER 350 is 1wt%, and its particle size is 2.6μm, and the weight percentage of TRF-6514 is 99wt%.

[0181] The antibacterial performance data obtained by testing according to GBT31402-2015 standard show that the antibacterial rate of the antibacterial plastic against Escherichia coli and Staphylococcus aureus is greater than 99%, and the bactericidal rate drops to about 80% after 6 months. The details of various parameters are shown in Table 1.

[0182] Table 1 shows the parameters of each embodiment and comparative example.

[0183]

[0184]

[0185] Summary: After the experimental test of the above examples, the results show that after adding antistatic agent and tungsten-molybdenum salt antibacterial agent to the first plastic matrix / thermoplastic elastic resin, or more simply, after adding antibacterial agent to the second plastic matrix, the plastic surface has good and lasting antibacterial effect. Using the second plastic matrix or polymer antistatic agent can form a semi-permanent antibacterial plastic with good antibacterial properties.

[0186] Embodiment 20

[0187] The antibacterial plastic in Example 2 is made into a balloon, a pipeline (balloon cavity, drainage cavity, flushing cavity), a conical port connector (single cavity, double cavity), and a one-way valve, such as Figure 1 The preparation method of the antibacterial urinary catheter shown is:

[0188] 1.1 Bond the conical fitting to the pipeline: Use special tooling to locate each cavity of the pipeline and bond.

[0189] 1.2 Head molding: Use special end molding machine and mold.

[0190] 1.3 Punching: connect the balloon hole with the balloon cavity, connect the drainage hole with the drainage cavity, and connect the flushing hole with the flushing cavity.

[0191] 1.4 Balloon bonding: The balloon is inserted into the front end of the catheter and bonded to the tube, and the balloon cavity of the tube is connected to the balloon.

[0192] 1.5 Installation of one-way valve: Install the one-way valve into the balloon cavity end of the tapered joint and fix the seal with adhesive.

[0193] 1.6 Printing: A pad printer prints specification marks to obtain the antibacterial urinary catheter of the present application.

[0194] According to statistics, there are currently about 6 types of antibacterial coating technologies in the field of urology that are in the laboratory research or early application stage, including antimicrobial peptide coatings, bacteriophage coatings, carbon nanocoatings, nitric oxide release coatings, metal and metal oxide nanoparticle coatings, and antifouling coatings. These technologies have defects such as short validity period, toxicity, or limited use conditions, and further research and improvement are needed. There are 3 catheter products developed based on antibacterial coating technology that have been put on the market, including silver ion antibacterial coatings, antibiotic coatings, and antibacterial enzyme coatings. However, the silver ion antibacterial coating has a short validity period and loses its activity in a sulfide environment; the antibiotic coating has difficulties in controlling the sustained release process and drug resistance problems; the production cost of the antibacterial enzyme coating is high, and the transportation and sterilization conditions are complex. In contrast, the laboratory test data of the antibacterial catheter based on this embodiment shows that since the antibacterial catheter is embedded with active substances, it does not fall off, precipitate, is non-toxic, and is non-irritating; a hydrophilic antibacterial layer is formed on the surface, and the antibacterial effect is achieved through non-contact sterilization, with high safety and good stability. In a neutral water environment, for a concentration of 10 5 The antibacterial rate of Escherichia coli and Staphylococcus aureus was greater than 99%. 5 The antibacterial rate of CFU / mL of Escherichia coli and Staphylococcus aureus is greater than 90%, and no biofilm grows, making it suitable for application in the field of urology.

[0195] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An antibacterial urinary catheter, wherein: Made of antimicrobial plastic; The antimicrobial plastic comprises at least one first plastic matrix, a second plastic matrix or a thermoplastic elastomer material (TPE) and at least one antimicrobial agent; The antimicrobial agent comprises molybdenum and / or tungsten metal, or metal oxides thereof, or molybdenum and / or tungstates, or molybdates and zincates, or zincates, or polyoxometalates (POM) containing molybdenum and / or tungsten.

2. The antibacterial urinary catheter according to claim 1, wherein: In the antibacterial plastic, the weight percentage of the antibacterial agent is 0.01-50wt%.

3. The antibacterial urinary catheter according to claim 1, wherein: The antibacterial plastic also includes an antistatic agent, and the weight percentage of the antistatic agent is 0.01-30wt%.

4. The antibacterial urinary catheter according to claim 1, wherein: In the antibacterial plastic, the weight percentage of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material is 50-99wt%.

5. The antibacterial urinary catheter according to claim 1, wherein: The particle size of the antibacterial agent is 1 nm-100 μm.

6. The antibacterial urinary catheter according to claim 3, wherein: The antistatic agent is one or more of a cationic antistatic agent, an anionic antistatic agent, an amphoteric antistatic agent, a nonionic antistatic agent or a polymer antistatic agent, preferably a nonionic antistatic agent or a polymer antistatic agent; Preferably, the nonionic antistatic agent is selected from one or more of ethylene oxide amines, ethoxylated amines, alkyl block polyethers, ethyl sulfate salts, polyethylene oxide, polyethylene glycol esters or ethers, polyol fatty acid esters, fatty acid alkanolamides, fatty amine ethoxylated ethers, glycerol, polyglycerol, sorbitol, polyols, and stearic acid monoglyceride, more preferably alkyl block polyethers or ethoxylated amines. Preferably, the polymer antistatic agent is a polyether polymer antistatic agent or an ionic polymer antistatic agent. The polyether-type polymer antistatic agent is a polyether / polyolefin block polymer or a polyether compound, wherein the polyether compound is selected from one or more of polyethylene oxide (PEO), polyether ester amide (PEEA), polyether ester imide (PEAI), polyethylene oxide-epichlorohydrin copolymer (PEO-ECH) and polyethylene glycol methacrylic acid copolymer (PEGM), preferably a polyether compound (polyether / polyolefin block polymer), polyether ester amide (PEEA) and polyether ester imide (PEAI) compound; The ionic polymer antistatic agent is obtained by introducing small molecule salts into polymer side groups through polymer chemical reaction, and is preferably a quaternary ammonium salt polymer antistatic agent or a sulfonate salt polymer antistatic agent.

7. The antibacterial urinary catheter according to claim 1, wherein: The first plastic matrix is ​​selected from one or more of polypropylene PP, polyethylene PE, polyvinyl chloride PVC, polycarbonate PC, polystyrene PS, polyamide PA, polylactic acid PLA, polyethylene glycol PEG or acrylonitrile-butadiene-styrene copolymer ABS.

8. The antibacterial urinary catheter according to claim 1, wherein: The thermoplastic elastomer material (TPE) is selected from one or more of polyurethane thermoplastic elastomer TPU, styrene thermoplastic elastomer TPS, olefin thermoplastic elastomer TPO, dynamically vulcanized thermoplastic elastomer TPV, polyester thermoplastic elastomer TPEE, and polyamide thermoplastic elastomer TPA.

9. The antibacterial urinary catheter according to claim 1, wherein: The second plastic matrix is ​​selected from one or more of polyacrylamide, polyamide, polyacrylic acid, polysulfonate polyvinyl alcohol, cellulose, starch, polysaccharide, and polyethylene oxide.

10. The antibacterial urinary catheter according to claim 1, wherein: The antibacterial agent includes one or more of molybdenum oxide, tungsten oxide, zinc molybdate, blue tungsten and POM, preferably zinc molybdate or blue tungsten.

11. The antibacterial urinary catheter according to claim 1, wherein: The valence of the molybdenum element or the tungsten element in the antibacterial agent is +4 to +6.

12. The antibacterial urinary catheter according to claim 1, wherein: The plastic contains metal elements of the antimicrobial agent through X-ray fluorescence spectrometry (XRF) or X-ray photoelectron spectroscopy (XPS).

13. The antimicrobial urinary catheter according to claim 1, wherein: The method for preparing the antibacterial plastic comprises the following steps: The first plastic matrix, the second plastic matrix or at least one of the thermoplastic elastomer material (TPE) and the antibacterial agent are mixed and directly extruded to obtain the antibacterial plastic, or the first plastic matrix, the second plastic matrix or at least one of the thermoplastic elastomer material and the antibacterial agent are uniformly mixed and kneaded by a mixing process, and then the kneaded raw materials are added to an extruder and extruded, or the first plastic matrix, the second plastic matrix or at least one of the thermoplastic elastomer material and the antibacterial agent are first mixed with the antibacterial agent to prepare a high-concentration antibacterial masterbatch by means of a kneading process, and then at least one of the first plastic matrix, the second plastic matrix or the thermoplastic elastomer material is added to dilute it, and then extruded to obtain the antibacterial plastic; The antimicrobial agent comprises molybdenum and / or tungsten metal, or metal oxides thereof, or molybdenum and / or tungstates, or molybdates and zincates, or zincates, or polyoxometalates (POM) containing molybdenum and / or tungsten.

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