Decoloring and purifying equipment for preparing 1, 4-butanedisulfonic acid adenosyl methionine salt through electrodialysis

Abstract

The invention relates to decoloring and purifying equipment for preparing 1, 4-butanedisulfonic acid ademetionine salt through electrodialysis, and belongs to the technical field of chemical purification. The decoloring and purifying equipment for preparing 1, 4-butanedisulfonic acid adenosyl methionine salt through electrodialysis comprises a fixing frame, the upper end of the fixing frame is fixedly connected with a servo motor, and an output shaft of the servo motor is fixedly connected with a gear; the purification mechanism is mounted on the surface of the fixing frame, and the surface of the purification mechanism extends into the fixing frame; the concentration of the liquid medicine can be changed by controlling the temperature change, when the device filters the liquid medicine, the decolorized liquid medicine can form crystals to be separated out, the separated crystals can be retained by stopping rotating centrifugation of the liquid medicine, the liquid level is kept horizontal under the action of gravity, and part of the liquid medicine flows through the filter layer again, so that the liquid medicine is filtered out. Impurities in the liquid medicine can be retained in the filter layer and the cylinder, so that the processing steps are simplified, and the production efficiency is improved.

Description

Technical Field

[0001] The invention relates to the technical field of chemical purification, in particular to a decolorization and purification device for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis. Background Art

[0002] 1,4-Butanedisulfonic acid adenosylmethionine molecule, molecular weight 758.55. Used to treat cholestasis. Its active ingredient is adenosylmethionine cation, and 1,4-butanedisulfonic acid is paired with it as an anion to stabilize its structure. Adenosylmethionine is the active form of methionine in the body and participates in various metabolisms as an important methyl, thiol and aminopropyl donor. It is widely used in the treatment of various liver-related diseases, such as intrahepatic cholestasis, drug-induced liver injury, viral hepatitis and alcoholic liver disease.

[0003] In the electrodialysis device, a two-chamber bipolar membrane replacement is used to collect the material reflux liquid to obtain the crude product of 1,4-butanedisulfonic acid adenosylmethionine salt. Then, the crude product of 1,4-butanedisulfonic acid adenosylmethionine salt flows through a macroporous adsorption material, which can be a resin or activated carbon, to obtain 1,4-butanedisulfonic acid adenosylmethionine salt with a HPLC test result of adenosylmethionine in the solution of ≥98%. During the purification process, the solution can be decolorized by activated carbon. Activated carbon has a strong adsorption capacity and can effectively remove pigments and other colored impurities. During the purification process, it may be necessary to add appropriate salts (such as sodium butanedisulfonate) for salting out to change the solubility of the solution and help separate the target compound. The target compound needs to be redissolved in an appropriate solvent. The existing purification step requires the use of ion exchangers such as resin Dowex-50 (100-200 mesh, 8% cross-linking degree) to remove impurities. However, in the production process, in order to remove smaller suspended matter, colloidal particles and insoluble by-products produced during chemical reactions or purification processes, a single purification filtration will still have some residual impurities that affect the purification concentration, and multiple filtrations are required to improve the purity, resulting in a longer purification operation time and affecting production efficiency. Summary of the invention

[0004] Based on this, it is necessary to decolorize and purify adenosylmethionine butanedisulfonate. Since the concentration of a single purification process is not enough, this production step needs to be repeated many times to improve the purity. The long purification operation time affects the production efficiency. A decolorization and purification device for preparing 1,4-adenosylmethionine butanedisulfonate salt by electrodialysis is provided.

[0005] A decolorization and purification device for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis, comprising: a fixed frame, the upper end of which is fixedly connected to a servo motor, and the output shaft of the servo motor is fixedly connected to a gear; a purification mechanism, which is installed on the surface of the fixed frame, and the surface of the purification mechanism extends to the inside of the fixed frame; wherein the purification mechanism includes a purification component arranged on the inner wall of the fixed frame, the interior of the purification component is provided with a temperature component, the surface of the temperature component extends to the outside of the fixed frame, and the lower end of the purification component is provided with a lead-out heating component.

[0006] In one embodiment, the purification component includes a support frame fixedly connected to the inner wall of the fixed frame, the surface of the support frame is rotatably connected to a rotating bin, the surface of the rotating bin is fixedly connected to a gear ring, the gear ring is meshingly connected to a gear, the inner wall of the rotating bin is fixedly connected to a plurality of temperature-conducting arc plates, the temperature-conducting arc plates are fixedly connected to a rubber arc plate away from the inner wall of the rotating bin, both sides of the temperature-conducting arc plates are fixedly connected to fixed arc edge strips, and the side of the adjacent fixed arc edge strip away from the inner wall of the rotating bin is fixedly connected to a filter layer. When the gear rotates, the rotating bin will be driven to rotate by the gear ring meshing therewith, and at this time, since the support frame is fixedly connected to the surface of the fixed frame, the support frame will follow the fixed frame and remain motionless, and will support the rotating bin to maintain the effect of rotation.

[0007] In one embodiment, the temperature component includes a central heating seat arranged in the central area of ​​the rotating bin, a rubber ring is fixedly connected to the upper surface of the central heating seat, a heating inner cavity is opened inside the central heating seat, a hot air hard conduit is fixedly connected to the inner wall of the heating inner cavity, a hot air mass collection bin is fixedly connected to the upper end of the hot air hard conduit, a guide twisting plate is fixedly connected to the lower surface of the central heating seat, a mixing blade is arranged at the upper end of the guide twisting plate, and the mixing blade is fixedly connected to the surface of the central heating seat. To reduce the probability of substances affecting purity reaching the inner cavity, the surface material of the central heating seat is a thermal conductive material, which can heat the liquid medicine in contact with its surface.

[0008] In one embodiment, the heat extraction and heating assembly includes a heat-conducting column fixedly connected to the lower end of the rotating bin, the inner wall of the heat-conducting column is fixedly connected to a plurality of extraction tubes, the upper end of the extraction tube passes through the interior of the rotating bin, the lower end of the extraction tube is fixedly connected to a lower conduit connected to the extraction tube, the surface of the lower conduit is concavely fixedly connected to a heating block, the upper end of the heating block passes through the interior of the heat-conducting column, the surface of the heating block is fixedly connected to a heat-conducting heating plate, and the heat-conducting heating plate is fixedly connected to the surface of the extraction tube. The longitudinal section of the lower conduit is Y-shaped, and the upper extraction tube is annularly distributed at the upper end of the lower conduit, and the lower end of the extraction tube is connected to the upper end of the lower conduit.

[0009] In one embodiment, the temperature assembly further comprises a vortex tube fixedly connected to the surface of the fixing frame, the upper and lower ends of the vortex tube are fixedly connected to a hard tube, the other end of the hard tube at the lower end penetrates into the interior of the fixing frame and is fixedly connected to a sealing rotating ring, the sealing rotating ring is fixedly connected to the inner wall of the fixing frame, and the other end of the hard tube at the upper end is fixedly connected to the upper end of the hot air mass collection chamber. The hard tube at the upper end is in communication with the hot air mass collection chamber.

[0010] In one embodiment, an annular hard arc ring is fixedly connected to the bottom wall of the rotating bin, and the side of the annular hard arc ring close to the inner wall of the rotating bin is combined with the inner wall of the rotating bin to form a collection bin, and an air guide ring groove is opened on the surface of the rotating bin. The concave arc surface of the annular hard arc ring is fixedly connected to the arc surface of the temperature conduction arc plate, and the crystals precipitated during the centrifugation process will fall into the interior of the collection bin under the action of gravity.

[0011] In one embodiment, the inner wall of the temperature-conducting arc plate is fixedly connected with a cryogenic tube, one end of the cryogenic tube is connected to the air-conducting ring groove, and the other end of the cryogenic tube passes through the upper end of the rotating bin. The temperature-conducting arc plate and the cryogenic tube are made of a temperature-conducting component, and the specific material can be appropriately adjusted according to the use environment.

[0012] In one embodiment, a supporting ring groove is provided at the upper end of the rotating bin, and a plurality of balls are rotatably connected to the top wall of the supporting ring groove, and the balls are in contact with the surface of the supporting frame, so that when the rotating bin rotates, it will be stably supported and the friction effect will be reduced under the action of the balls.

[0013] In one embodiment, an air outlet plug is provided between adjacent mixing blades, the air outlet plug is embedded in the surface of the middle heating seat, and the air outlet plug is connected to the heating inner cavity. A plurality of holes are provided on the surface of the air outlet plug, so that the ejected hot air mass can form relatively uniform and dense small bubbles.

[0014] In one embodiment, a heating plate is fixedly connected to the inner wall of the lower conduit, and the heating plate is spiral-shaped. The spiral arrangement of the heating plate can increase the heating path of the liquid medicine.

[0015] The above-mentioned decolorization and purification equipment for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis can reciprocately decolorize and filter the drug solution under centrifugal action for multiple times through a purification mechanism, and in the decolorization and filtering process, the concentration of the drug solution can be changed by controlling the temperature change. While filtering the drug solution, the device can also cause the decolorized drug solution to form crystals and precipitate. Stopping the rotation and centrifugation of the drug solution will allow the precipitated crystals to be retained and the liquid level to be maintained under the action of gravity. Part of the drug solution will flow through the filter layer again, and the impurities in the drug solution will be retained in the filter layer and the cylinder, thereby simplifying the processing steps and improving the production efficiency.

[0016] The device heats the medicine liquid inside the rotating bin by means of a set temperature component, and injects hot air into the rotating bin through a vortex tube, so that the temperature of the medicine liquid in the middle area of ​​the rotating bin rises, and reduces the crystal precipitation of the medicine liquid in the middle area of ​​the rotating bin. In addition, the medicine liquid can be mixed during the centrifugal process, so that the medicine liquid is evenly heated, and the precipitated crystals are assisted to dissolve in the medicine liquid, thereby optimizing the filtering and purification effect of the purification component and ensuring the improvement of production efficiency.

[0017] By cooperating with the extraction and heating component, the temperature of the medicine liquid near the inner wall of the rotating bin can be lowered and filtered and decolorized, and the precipitated crystals can be collected during the centrifugation process. The extraction and heating component collects and extracts the precipitated crystals during the rotation process, and the heating operation is performed during the extraction process, so that the precipitated crystals will be dissolved in the liquid again during the extraction process, so that the concentration of the single extraction liquid is increased, the number of repeated purification operations is reduced, and the production efficiency is helped to be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the present invention or the prior art, a brief introduction is given below to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0019] Figure 1 It is a structural schematic diagram of the present invention;

[0020] Figure 2 It is a schematic diagram of the purification mechanism structure of the present invention;

[0021] Figure 3 It is a schematic diagram of the internal structure of the rotating bin of the present invention;

[0022] Figure 4 It is a schematic diagram of the position of the annular hard arc loop of the present invention;

[0023] Figure 5 This is a schematic diagram of the connection between the fixed arc edge strip and the filter layer of the present invention;

[0024] Figure 6 It is a schematic diagram of the local structure of the temperature component of the present invention;

[0025] Figure 7 A partial cross-sectional view of a temperature component of the present invention;

[0026] Figure 8 A schematic diagram of the air guide ring groove of the present invention;

[0027] Fig. 9 It is a schematic diagram of the partial explosion structure of the purification component of the present invention;

[0028] Fig.10 A schematic diagram of the support ring groove of the present invention;

[0029] Fig.11 A cross-sectional view of a lead-out heating assembly of the present invention;

[0030] Fig.12 It is an exploded cross-sectional view of the lead-out heating component of the present invention.

[0031] Reference numerals:

[0032] 100, fixed frame; 200, servo motor; 210, gear; 300, purification mechanism; 310, purification assembly; 311, rotating chamber; 312, gear ring; 313, temperature conduction arc plate; 314, rubber arc plate; 315, fixed arc edge strip; 316, filter layer; 317, low temperature tube; 318, annular hard arc ring; 319, collection chamber; 3110, air guide ring groove; 3111, supporting ring groove; 3112, supporting frame; 3113, ball; 320, temperature Component; 321, vortex tube; 322, sealing rotating ring; 323, mixing blade; 324, guide twisting plate; 325, hot air mass gathering chamber; 326, hot air hard conduit; 327, middle heating seat; 328, rubber ring; 329, heating inner cavity; 3210, air outlet plug; 330, outlet heating component; 331, heat-conducting column; 332, outlet pipe; 333, heating block; 334, lower conduit; 335, temperature-conducting heating plate; 336, heating plate. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0034] It should be noted that when a component is referred to as being "fixed to" or "disposed on" another component, it may be directly on the other component or there may be a central component. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may be a central component at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in the specification of the present invention are for illustrative purposes only and do not represent the only implementation method.

[0035] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0036] In the present invention, unless otherwise clearly specified and limited, a first feature being “above” or “below” a second feature may mean that the first feature is directly in contact with the second feature, or the first feature and the second feature are indirectly in contact through an intermediate medium. Moreover, a first feature being “above”, “above” or “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being “below”, “below” or “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0037] Unless otherwise defined, all technical and scientific terms used in the specification of the present invention have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used in the specification of the present invention includes any and all combinations of one or more related listed items.

[0038] Combine the following Figure 1-Figure 12 The decolorization and purification device for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis of the present invention comprises: a fixed frame 100, a servo motor 200 is fixedly connected to the upper end of the fixed frame 100, and a gear 210 is fixedly connected to the output shaft of the servo motor 200; a purification mechanism 300, the purification mechanism 300 is installed on the surface of the fixed frame 100, and the surface of the purification mechanism 300 extends to the inside of the fixed frame 100; wherein the purification mechanism 300 comprises a purification component 310 arranged on the inner wall of the fixed frame 100, a temperature component 320 is arranged inside the purification component 310, and the surface of the temperature component 320 extends to the outside of the fixed frame 100, and a lead-out heating component 330 is arranged at the lower end of the purification component 310;

[0039] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 8 , Fig. 9 , Fig.10As shown, the purification component 310 includes a supporting frame 3112 fixedly connected to the inner wall of the fixed frame 100, the surface of the supporting frame 3112 is rotatably connected to the rotating bin 311, the surface of the rotating bin 311 is fixedly connected to the gear ring 312, the gear ring 312 is meshingly connected to the gear 210, the inner wall of the rotating bin 311 is fixedly connected to a plurality of temperature conducting arc plates 313, the temperature conducting arc plates 313 are fixedly connected to the inner wall of the rotating bin 311 away from the rubber arc plates 314, both sides of the temperature conducting arc plates 313 are fixedly connected to fixed arc edge strips 315, and the side of the adjacent fixed arc edge strips 315 away from the inner wall of the rotating bin 311 is fixedly connected to the filter layer 316. An annular hard arc ring 318 is fixedly connected to the inner bottom wall of the rotating bin 311. The side of the annular hard arc ring 318 close to the inner wall of the rotating bin 311 is combined with the inner wall of the rotating bin 311 to form a collecting bin 319. An air guide ring groove 3110 is provided on the surface of the rotating bin 311. A low temperature tube 317 is fixedly connected to the inner wall of the temperature conducting arc plate 313. One end of the low temperature tube 317 is connected to the air guide ring groove 3110. The other end of the low temperature tube 317 passes through the upper end of the rotating bin 311. A supporting ring groove 3111 is provided at the upper end of the rotating bin 311. A plurality of balls 3113 are rotatably connected to the inner top wall of the supporting ring groove 3111. The balls 3113 are in contact with the surface of the supporting frame 3112.

[0040] When the servo motor 200 of the device is driven, the gear 210 is driven to rotate synchronously. At this time, the gear 210 is meshed with the gear ring 312 to drive the rotating chamber 311 to rotate synchronously. When the rotating chamber 311 rotates, it drives the temperature conducting arc plate 313 and the rubber arc plate 314 to rotate synchronously. At this time, part of the liquid is located in the cylinder formed by the combination of multiple filter layers 316. When the rotating chamber 311 rotates, the rubber arc plate 314 drives the liquid to perform centrifugal motion. At this time, the liquid inside the cylinder passes through the filter layer 316 under the action of centrifugal force for filtration and decolorization. The liquid enters the area between the filter layer 316 and the rotating chamber 311. The region is divided into several inner chambers with the assistance of multiple temperature-conducting arc plates 313, and the temperature-conducting arc plates 313 and the low-temperature tubes 317 are in contact with the filtered and decolorized liquid under the action of the low-temperature tubes 317, so that the liquid temperature is reduced, the internal medicine liquid becomes supersaturated, and crystals are precipitated, and then the rotation is slowly stopped. At this time, under the action of the filter layer 316, the precipitated crystals are difficult to pass through the filter layer 316 and remain in the inner chamber. The liquid passes through the filter layer 316 again and flows back to the cylinder. Then the rotating chamber 311 can be rotated again. After repeated multiple times, the crystals precipitated from the medicine liquid in the inner chamber can be gradually increased, thereby improving the concentration of the medicine liquid in the inner chamber.

[0041] The concave arc surface of the annular hard arc ring 318 is fixedly connected to the arc surface of the temperature conducting arc plate 313. When the rotating bin 311 rotates, the precipitated crystals in the inner cavity are attached to the inner cavity away from the rubber arc plate 314. When the rotating bin 311 stops rotating, most of the precipitated crystals fall into the collecting bin 319 under the action of gravity, reducing the precipitated crystals from flowing back into the cylinder, thereby achieving the goal of improving the concentration of the liquid medicine while filtering and decolorizing the liquid medicine.

[0042] like Figure 1 , Figure 2 , Figure 3 , Figure 6 , Figure 7 , Fig. 9 As shown, the temperature component 320 includes a central heating seat 327 arranged in the central area inside the rotating bin 311, a rubber ring 328 is fixedly connected to the upper end of the surface of the central heating seat 327, a heating inner cavity 329 is opened inside the central heating seat 327, a hot air hard conduit 326 is fixedly connected to the inner wall of the heating inner cavity 329, the upper end of the hot air hard conduit 326 is fixedly connected to the hot air mass gathering bin 325, the lower end of the surface of the central heating seat 327 is fixedly connected to the guide twisting plate 324, the upper end of the guide twisting plate 324 is provided with a mixing blade 323, and the mixing blade 323 is fixedly connected to the surface of the central heating seat 327. The temperature assembly 320 also includes a vortex tube 321 fixedly connected to the surface of the fixing frame 100. The upper and lower ends of the vortex tube 321 are fixedly connected to hard tubes. The other end of the lower hard tube penetrates into the interior of the fixing frame 100 and is fixedly connected to a sealing rotating ring 322. The sealing rotating ring 322 is fixedly connected to the inner wall of the fixing frame 100. The other end of the upper hard tube is fixedly connected to the upper end of the hot air mass collection chamber 325. An air outlet plug 3210 is provided between adjacent mixing blades 323. The air outlet plug 3210 is embedded and installed on the surface of the middle heating seat 327. The air outlet plug 3210 is connected to the heating inner cavity 329.

[0043] The device is connected with a high-pressure air guide pipe at the air inlet on the side of the vortex tube 321, which can be connected to the high-pressure gas externally, and the cold air port at the lower end of the vortex tube 321 introduces the low-temperature gas into the interior of the air guide ring groove 3110 through a hard pipe. At this time, the air guide ring groove 3110 allows the cold air to enter the low-temperature tube 317, and the liquid inside the inner cavity is cooled and crystals are precipitated. At the same time, the hard pipe at the upper end of the vortex tube 321 will inject the hotter gas into the hot gas hard guide tube 326 through the hot gas mass collection bin 325, and the hotter gas enters the heating inner cavity 329 inside the middle heating seat 327 through the hot gas hard guide tube 326. At this time, the hotter gas is emitted to the outside through the air outlet plug 3210 on the surface of the middle heating seat 327. At the same time, the hot gas mass heats the internal medicine liquid, so that the occurrence of crystal precipitation in the medicine liquid is reduced.

[0044] As the rotating bin 311 rotates, the liquid medicine rotates along with the rotating bin 311. At this time, the guide twisted plate 324 on the surface of the middle heating seat 327 will guide the partially rotating liquid while the liquid is rotating. As the liquid rotates, impurities are easily accumulated in the central area of ​​the rotation, and crystals precipitated from the liquid medicine may be retained in the accumulation there. At this time, under the action of the guide twisted plate 324, the central area of ​​the rotating liquid medicine can be gradually moved upward, and at the same time, under the action of the mixing blades 323, it is dispersed again to the surrounding areas above, so that the retained precipitated crystals can be mixed again, and in the process of mixing, they are mixed with the hot air mass emitted by the air outlet plug 3210, so that the temperature of the liquid medicine rises, and the precipitated crystals are dissolved in the liquid medicine again, and the decolorization and filtration operation is performed to reduce the crystal precipitation of the liquid medicine in the cylinder.

[0045] like Figure 1 , Figure 2 , Figure 3 , Fig.10 , Fig.11 , Fig.12 As shown, the outlet heating assembly 330 includes a heat-conducting column 331 fixedly connected to the lower end of the rotating bin 311, and a plurality of outlet pipes 332 are fixedly connected to the inner wall of the heat-conducting column 331. The upper ends of the outlet pipes 332 penetrate into the interior of the rotating bin 311, and the lower ends of the outlet pipes 332 are fixedly connected to the lower conduit 334 communicating with the outlet pipes 332. The surface of the lower conduit 334 is concavely fixedly connected to a heating block 333, and the upper end of the heating block 333 penetrates into the interior of the heat-conducting column 331. The surface of the heating block 333 is fixedly connected to a heat-conducting heating plate 335, and the heat-conducting heating plate 335 is fixedly connected to the surface of the outlet pipe 332. The inner wall of the lower conduit 334 is fixedly connected to a heating plate 336, and the heating plate 336 is spiral-shaped;

[0046] When the device is in use, since most of the crystals are precipitated from the retained medicine liquid inside the collection bin 319, and the angle between the inner bottom wall of the collection bin 319 and the horizontal plane is an acute angle, and the outlet pipe 332 is spiral, when the rotating bin 311 rotates, it is convenient for the precipitated crystals to enter the outlet pipe 332, and the situation of crystal reflux is reduced. The surface of the outlet pipe 332 is embedded with an electromagnetic valve, and by opening the electromagnetic valve, the low-temperature medicine liquid carrying the crystals that have precipitated some crystals can be introduced into the lower conduit 334 through the outlet pipe 332, wherein the heating block 333 generates heat to preheat the part of the outlet pipe 332 through the heat-conducting column 331, so that the crystals in the medicine liquid are dissolved in the medicine liquid again, thereby achieving the effect of increasing the concentration of the medicine liquid;

[0047] The heating block 333 can enhance the heating effect of the straight portion of the outlet pipe 332 through the thermal conductive heating plate 335, and when the medicine enters the lower conduit 334, the heating plate 336 inside the lower conduit 334 can further enhance the dissolution of crystals in the medicine. Since the heating plate 336 is spirally arranged, the medicine flows along the heating plate 336, extending the heating path. Furthermore, due to the thermal conductive material on the heating plate 336, the precipitated crystals in the medicine can be better dissolved in the medicine.

[0048] When the device is in use, the side air inlet of the vortex tube 321 is connected to the high-pressure air guide pipe. The high-pressure gas flows through the vortex tube 321, so that the cold air port at the lower end guides the low-temperature gas into the interior of the air guide ring groove 3110 through the hard pipe. At this time, the cold air in the air guide ring groove 3110 enters the low-temperature tube 317, cools the liquid inside the inner cavity, and causes crystals to precipitate. At the same time, the hard pipe at the upper end of the vortex tube 321 will inject the hotter gas into the hot gas hard conduit 326 through the hot gas mass collection bin 325. The hotter gas enters the heating inner cavity 329 inside the middle heating seat 327 through the hot gas hard conduit 326. At this time, the hotter gas is dissipated to the outside through the air outlet plug 3210 on the surface of the middle heating seat 327. The air mass heats up the internal medicine liquid, and reduces the precipitation of crystals in the cylinder in the medicine liquid; the servo motor 200 is driven to make the rotating chamber 311 rotate synchronously under the meshing connection of the gear 210 and the gear ring 312, and the rotating chamber 311 rotates synchronously through the temperature-conducting arc plate 313 and the rubber arc plate 314 to drive the internal medicine liquid to centrifuge, and the medicine liquid passes through the filter layer 316 for filtration and decolorization under the action of centrifugal force, and the liquid enters the area between the filter layer 316 and the rotating chamber 311, and the multiple temperature-conducting arc plates 313 are separated into a plurality of inner cavities, and under the action of the low-temperature tube 317, the temperature-conducting arc plates 313 and the low-temperature tube 317 are in contact with the filtered and decolorized liquid, and the liquid temperature is reduced, and crystals precipitate from the internal medicine liquid;

[0049] As the rotating bin 311 rotates, the medicine liquid rotates with the rotating bin 311. At this time, the guide twisting plate 324 on the surface of the middle heating seat 327 will guide the partially rotating liquid while the liquid rotates, and the retained precipitated crystals will be mixed again. In the process of mixing, they will be mixed with the hot air mass emitted by the air outlet plug 3210, and the precipitated crystals will be dissolved in the medicine liquid again. Then the rotation will be slowly stopped. At this time, under the action of the filter layer 316, the precipitated crystals are difficult to pass through the filter layer 316 and remain in the inner cavity. When the rotating bin 311 stops rotating, most of the precipitated crystals fall into the interior of the collecting bin 319 under the action of gravity, and then the rotating bin 311 is rotated again. 1. After repeated steps, the amount of crystals precipitated from the medicine solution in the inner cavity gradually increases, and the concentration of the medicine solution in the inner cavity is increased. The crystals precipitated from the medicine solution in the collection chamber 319, when the rotating chamber 311 rotates, the precipitated crystals enter the outlet pipe 332, and are introduced into the lower conduit 334, wherein the heating block 333 generates heat to preheat a portion of the outlet pipe 332 through the heat-conducting column 331, and the heating block 333 enhances the heating effect of the straight portion of the outlet pipe 332 through the heat-conducting heating plate 335, wherein the heating plate 336 is spirally arranged, the medicine solution flows along the heating plate 336, and due to the heat-conducting material on the heating plate 336, the precipitated crystals in the medicine solution are better dissolved in the medicine solution.

[0050] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0051] The above-described embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that, for a person of ordinary skill in the art, several modifications and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the attached claims.

Claims

1. A decolorization and purification device for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis, characterized in that: include: A fixed frame (100), wherein the upper end of the fixed frame (100) is fixedly connected to a servo motor (200), and the output shaft of the servo motor (200) is fixedly connected to a gear (210); A purification mechanism (300), wherein the purification mechanism (300) is mounted on a surface of the fixing frame (100), and the surface of the purification mechanism (300) extends to the interior of the fixing frame (100); The purification mechanism (300) includes a purification component (310) arranged on the inner wall of the fixed frame (100), a temperature component (320) is arranged inside the purification component (310), the surface of the temperature component (320) extends to the outside of the fixed frame (100), and a derivation heating component (330) is arranged at the lower end of the purification component (310).

2. The decolorization and purification equipment for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis according to claim 1, characterized in that: The purification component (310) comprises a supporting frame (3112) fixedly connected to the inner wall of the fixed frame (100); the surface of the supporting frame (3112) is rotatably connected to a rotating bin (311); the surface of the rotating bin (311) is fixedly connected to a gear ring (312); the gear ring (312) is meshingly connected to a gear (210); the inner wall of the rotating bin (311) is fixedly connected to a plurality of temperature conducting arc plates (313); the temperature conducting arc plates (313) are fixedly connected to the inner wall away from the rotating bin (311) with rubber arc plates (314); both sides of the temperature conducting arc plates (313) are fixedly connected to fixed arc edge strips (315); and a filter layer (316) is fixedly connected to the side of the adjacent fixed arc edge strip (315) away from the inner wall of the rotating bin (311).

3. The decolorization and purification equipment for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis according to claim 2, characterized in that: The temperature component (320) comprises a central heating seat (327) arranged in the central area inside the rotating bin (311); a rubber ring (328) is fixedly connected to the upper end of the surface of the central heating seat (327); a heating inner cavity (329) is provided inside the central heating seat (327); a hot air hard conduit (326) is fixedly connected to the inner wall of the heating inner cavity (329); a hot air mass gathering bin (325) is fixedly connected to the upper end of the hot air hard conduit (326); a guide twisting plate (324) is fixedly connected to the lower end of the surface of the central heating seat (327); a mixing blade (323) is provided at the upper end of the guide twisting plate (324); and the mixing blade (323) is fixedly connected to the surface of the central heating seat (327).

4. The decolorization and purification equipment for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis according to claim 2, characterized in that: The degassing heating assembly (330) comprises a heat-conducting column (331) fixedly connected to the lower end of the rotating bin (311); a plurality of degassing pipes (332) are fixedly connected to the inner wall of the heat-conducting column (331); the upper ends of the degassing pipes (332) extend through the interior of the rotating bin (311); the lower ends of the degassing pipes (332) are fixedly connected to a lower conduit (334) connected to the degassing pipes (332); a heating block (333) is fixedly connected to the concave surface of the lower conduit (334); the upper end of the heating block (333) extends through the interior of the heat-conducting column (331); a heat-conducting heating plate (335) is fixedly connected to the surface of the heat-conducting heating plate (335); and the heat-conducting heating plate (335) is fixedly connected to the surface of the degassing pipe (332).

5. The decolorization and purification equipment for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis according to claim 3, characterized in that: The temperature component (320) further comprises a vortex tube (321) fixedly connected to the surface of the fixing frame (100), wherein the upper and lower ends of the vortex tube (321) are both fixedly connected to hard tubes, the other end of the hard tube at the lower end penetrates into the interior of the fixing frame (100) and is fixedly connected to a sealing rotating ring (322), the sealing rotating ring (322) is fixedly connected to the inner wall of the fixing frame (100), and the other end of the hard tube at the upper end is fixedly connected to the upper end of the hot air mass gathering chamber (325).

6. The decolorization and purification equipment for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis according to claim 2, characterized in that: An annular hard arc ring (318) is fixedly connected to the inner bottom wall of the rotating bin (311); a side of the annular hard arc ring (318) close to the inner wall of the rotating bin (311) is combined with the inner wall of the rotating bin (311) to form a collecting bin (319); and an air guide ring groove (3110) is provided on the surface of the rotating bin (311).

7. The decolorization and purification equipment for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis according to claim 6, characterized in that: A low temperature tube (317) is fixedly connected to the inner wall of the temperature conducting arc plate (313), one end of the low temperature tube (317) is in communication with the air conducting ring groove (3110), and the other end of the low temperature tube (317) passes through the upper end of the rotating bin (311).

8. The decolorization and purification equipment for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis according to claim 7, characterized in that: A supporting ring groove (3111) is provided at the upper end of the rotating bin (311), and a plurality of balls (3113) are rotatably connected to the top wall of the supporting ring groove (3111), and the balls (3113) are in contact with the surface of the supporting frame (3112).

9. The decolorization and purification equipment for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis according to claim 3, characterized in that: An air outlet plug (3210) is provided between adjacent mixing blades (323), and the air outlet plug (3210) is embedded and installed on the surface of the middle heating seat (327), and the air outlet plug (3210) is communicated with the heating inner cavity (329).

10. The decolorization and purification equipment for preparing 1,4-butanedisulfonic acid adenosylmethionine salt by electrodialysis according to claim 4, characterized in that: A heating plate (336) is fixedly connected to the inner wall of the lower conduit (334), and the heating plate (336) is spiral-shaped.

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