Biological vaccine cell reactor

By using a swing mechanism driven by a servo motor in the biological vaccine cell reactor, the problem of damage to cells by the stirrer shear force is solved and the survival rate of cells is improved.

CN119220403APending Publication Date: 2024-12-31HUANGSHAN SAISI BOOU BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202411434204.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-15
Publication Date
2024-12-31

AI Technical Summary

Technical Problem

The shear force generated by the agitator in the bioreactor causes cell damage, reducing cell survival.

Method used

A biological vaccine cell reactor was designed, and a swing mechanism driven by a servo motor was used to enable the reaction tank to swing stably, and the materials rose and fell by inertia to mix, avoiding the damage to the cells by shear force.

Benefits of technology

The survival rate of cells is improved, and the damage to cells by the agitator is avoided through swing mixing technology, achieving more efficient cell culture.

✦ Generated by Eureka AI based on patent content.

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Abstract

According to the biological vaccine cell reactor, when a reaction tank penetrates through a lantern ring and is placed in a rubber base, the initial state of the reaction tank is a stable state, the reaction tank can conduct other operations, when materials in the reaction tank need to be stirred, a servo motor is started firstly, the servo motor drives a special-shaped frame to rotate, and the special-shaped frame is driven to rotate; in the rotating process of the special-shaped frame, the connecting rod is firstly driven to rotate, the first cross rod and the second cross rod on the connecting rod are separated from the protruding plate during rotation, after the protruding plate is not limited, the inserting rod can be rapidly pulled out of the socket, the lantern ring can rotate, the special-shaped frame can push the sliding base to move in a reciprocating mode along with the increase of the rotating speed of the special-shaped frame, and the swing base connected with the sliding base can swing in a reciprocating mode. Therefore, the reaction tank is driven to swing, materials in the swing tank can be mixed, and cells cannot be damaged in the mode, so that the storage rate of the cells is increased.
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Description

Technical Field

[0001] The present application relates to the field of reactor technology, and in particular to a biological vaccine cell reactor. Background Art

[0002] A bioreactor is a reaction chamber that uses microorganisms or cells to carry out biochemical processes. It simulates the environment in the body to achieve the synthesis, transformation and modification of biological macromolecules. In the field of biopharmaceuticals, bioreactors are mainly used to produce biological drugs such as antibodies, vaccines, cytokines, blood factors, enzymes, and to carry out research and development of cutting-edge technologies such as genetic engineering and cell therapy.

[0003] A bioreactor is an instrument used for cell culture. Cells are placed in a bioreactor for culture for a certain period of time. Oxygen is added to the reactor during the culture process, and then an agitator is used to stir the reactor during the oxygenation process. However, the shear force generated by the agitator during stirring can cause damage to the cells, ultimately resulting in a decrease in cell survival rate. Summary of the invention

[0004] One of the purposes of the present application is to provide a biological vaccine cell reactor.

[0005] To achieve the above objectives, the technical solution adopted in the present application is: a biological vaccine cell reactor, comprising a controller, a reaction tank, a servo motor, a liquid inlet and a sampling port, the reaction tank being plugged into a hoop, the side wall of the hoop being rotatably connected to a bracket, the bracket being fixedly connected to a base, an inner cavity being opened inside the base, a swing mechanism being removably connected inside the inner cavity, a swing seat being removably connected to the output end of the swing mechanism, a rubber seat being removably connected to the swing seat, the rubber seat being sleeved on the bottom of the reaction tank, a plug rod being slidably connected to the bracket, the plug rod being plugged into the socket of the hoop, the input end of the plug rod being overlapped by a tilting rod, a top plate being telescopically connected in the input direction of the tilting rod, a release mechanism being removably connected to the input end of the top plate, and the input end of the release mechanism being removably connected to the swing mechanism.

[0006] Preferably, a through slot is provided on the base, and a swing seat is slidably connected to the outer end position of the through slot, the diameter of the swing seat is larger than the diameter of the through slot, and a guide rod is detachably connected to the base, and a top plate is slidably connected to the guide rod, the top plate is arranged in a semicircular shape as a whole, and the two ends of the top plate are connected to the tilting rod.

[0007] Preferably, a baffle is provided on the upper end of the guide rod, the diameter of the baffle is larger than the diameter of the guide rod, a first spring is sleeved on the guide rod between the baffle and the top plate, one end of the first spring is detachably connected to the baffle, and the other end of the first spring is detachably connected to the upper end surface of the top plate.

[0008] Preferably, the bracket is arranged in an L-shape as a whole, a fixing seat is fixedly connected to the side wall of the bracket, an insertion rod is slidably connected to the fixing seat, a mounting seat is detachably connected to the input end of the insertion rod, the mounting seat is arranged in an L-shape as a whole, and an end of a corresponding tilting rod is overlapped at the bent position of the mounting seat.

[0009] Preferably, the bottom of the seat is removably connected to a limit rod, the limit rod is vertically arranged on the seat, the limit rod is slidably connected to the corresponding base, a third spring is sleeved on the insertion rod between the seat and the fixed seat, one end of the third spring is removably connected to the fixed seat, and the other end of the third spring is removably connected to the seat.

[0010] Preferably, the socket is provided with a socket, the socket corresponds to the position of the plug rod, the plug rod and the bracket are parallel to each other, the plug rod is arranged along the length of the bracket, and the plug rod is cylindrical.

[0011] Preferably, the release mechanism includes a convex plate, which is detachably connected to the side wall of the top plate, and the upper and lower sides of the convex plate are slidably connected to the first cross bar and the second cross bar, the first cross bar and the second cross bar are respectively fixed on the extension rod, and one end of the extension rod is detachably connected to the connecting rod.

[0012] Preferably, the convex plate is arranged in an arc shape as a whole, the extension rod and the connecting rod are arranged in an L shape as a whole, the first cross bar and the second cross bar are vertically arranged on the corresponding extension rod, and the first cross bar and the second cross bar are parallel to each other.

[0013] Preferably, the swing mechanism includes a servo motor, the input end of the servo motor is detachably connected to a special-shaped frame, one end of the special-shaped frame is detachably connected to a connecting rod, a sliding rod is horizontally arranged in the inner cavity above the special-shaped frame, a sliding seat is slidably connected to the sliding rod, the sliding seat is detachably connected to the swing seat, a first side frame and a second side frame are provided at one end of the sliding seat, and a second spring of the same structure is sleeved on the sliding rods on both sides of the sliding seat.

[0014] Preferably, the special-shaped frame is arranged in a U-shape as a whole, and the special-shaped frame is located between the first side frame and the second side frame. The first side frame and the second side frame are arranged in a U-shape as a whole, and one end of the second side frame has an inclined protrusion.

[0015] Compared with the prior art, the beneficial effects of this application are:

[0016] The biological vaccine cell reactor can open an inner cavity inside the base through the setting of the base, and a servo motor can be installed inside the inner cavity. A special-shaped frame is provided on the output end of the servo motor, and the servo motor can drive the special-shaped frame to rotate. One end of the special-shaped frame is connected to a connecting rod, and the connecting rod and the special-shaped frame can rotate at the same time. The special-shaped frame is located between the first side frame and the second side frame of the slide. When the special-shaped frame rotates, it will reciprocate and push the first side frame and the second side frame. When the special-shaped frame pushes the first side frame and the second side frame, the slide will reciprocate in two directions. The swing seat connected to the slide can realize activities in two directions to make the rubber seat swing. When a reaction tank is placed on the rubber seat, the reaction tank can swing after a sleeve ring is connected above the reaction tank. During the swinging process, the material in the reaction tank can first rise and then fall due to inertia to achieve mixing. Compared with a stirrer, it will not damage the cells, thereby improving the survival rate of the cells.

[0017] The biological vaccine cell reactor is characterized in that a connecting rod is installed on a special-shaped frame, and the connecting rod will rotate following the drive of the servo motor. When rotating, the connecting rod will drive the first cross bar and the second cross bar to move away from the convex plate, and the convex plate can move away from the first cross bar and the second cross bar. The top plate can be driven by the first spring, and the top plate can move up to push the tilting rod. During the rotation of the tilting rod, the seat will be pressed down, and the seat will drive the plug rod to be pulled out of the socket, and the ring can be rotated. The ring will not affect the rotation of the reaction tank when limiting the position of the reaction tank. The ring and the swing seat can cooperate to realize the stable swing of the reaction tank. After the top plate moves up, the convex plate on the top plate will move away from the first cross bar. There is a cross bar and a second cross bar. When the first cross bar and the second cross bar rotate with each other, they will not hit the convex plate, and the convex plate will not affect the rotation of the first cross bar and the second cross bar. When the equipment stops, the special-shaped frame is reset, and the personnel can be pressed on the top plate. After the top plate is reset, the first cross bar and the second cross bar can be clamped on the convex plate again as the special-shaped frame is reset, and the convex plate can be limited again, and the tilting rod will not be pushed. When the tilting rod does not push the seat, the second spring will drive the seat to reset. When the seat is reset, the plug connected to the seat will be inserted into the socket again, the socket can be fixed, the ring can be fixed, and the reaction tank will no longer rotate, thereby realizing the fixation of the reaction tank. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 The overall structure of the present invention is shown in FIG. Figure 1 .

[0019] Figure 2 The overall structure of the present invention is shown in FIG. Figure 2 .

[0020] Figure 3 It is a schematic diagram of the structure of the rubber seat in the present invention.

[0021] Figure 4 It is a structural schematic diagram of the through groove in the present invention.

[0022] Figure 5 It is a schematic diagram of the enlarged structure of area A in the present invention.

[0023] Figure 6 It is a schematic diagram of the enlarged structure of area B in the present invention.

[0024] Figure 7 It is a schematic diagram of the enlarged structure of the C region in the present invention.

[0025] In the figure: 1, controller; 2, reaction tank; 3, sampling port; 4, liquid inlet; 5, base; 6, bracket; 7, hoop; 8, socket; 9, limit rod; 10, seat; 11, baffle; 12, first spring; 13, guide rod; 14, top plate; 15, tilting rod; 16, socket; 17, rubber seat; 18, swing seat; 19, release mechanism; 191, convex plate; 192, connecting rod; 193, extension rod; 194, first cross bar; 195, second cross bar; 20, through groove; 21, inner cavity; 22, swing mechanism; 221, slide bar; 222, second spring; 223, first side frame; 224, servo motor; 225, second side frame; 226, special-shaped frame; 227, slide seat; 23, plug rod; 24, fixed seat; 25, third spring. DETAILED DESCRIPTION

[0026] Below, the present application is further described in conjunction with specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments.

[0027] like Figures 1 to 7As shown, the present invention provides a biological vaccine cell reactor, comprising a controller 1, a reaction tank 2, a servo motor 224, a liquid inlet 4 and a sampling port 3, the reaction tank 2 is plugged into the hoop 7, the side wall of the hoop 7 is rotatably connected to the bracket 6, the bracket 6 is fixedly connected to the base 5, an inner cavity 21 is opened inside the base 5, the inner cavity 21 is removably connected with a swing mechanism 22, the output end of the swing mechanism 22 is removably and fixedly connected with a swing seat 18, the swing seat 18 is removably connected with a rubber seat 17, the rubber seat 17 is sleeved on the bottom of the reaction tank 2, a plug rod 23 is slidably connected to the bracket 6, the plug rod 23 is plugged into the socket 8 of the hoop 7, the input end of the plug rod 23 is overlapped with the tilting rod 15, the tilting rod 15 is telescopically connected with the top plate 14 in the input direction, the input end of the top plate 14 is removably connected with a release mechanism 19, and the input end of the release mechanism 19 is removably connected to the swing mechanism 22. When the reaction tank 2 is passed through the sleeve ring and placed in the rubber seat 17, the initial state of the reaction tank 2 is a stable state, and the reaction tank 2 can perform other operations. When the material in the reaction tank 2 needs to be stirred, the servo motor 224 is started first, and the servo motor 224 will drive the special-shaped frame 226 to rotate. During the rotation of the special-shaped frame 226, the connecting rod 192 will be driven to rotate first, and the first cross bar 194 and the second cross bar 195 on the connecting rod 192 will be separated from the convex plate 191 during the rotation. After the convex plate 191 is not restricted, the plug rod 23 will be quickly pulled out of the socket 8, and the sleeve ring can be rotated. As the rotation speed of the special-shaped frame 226 increases, the special-shaped frame 226 will reciprocate to push the slide 227 to move, and the swing seat 18 connected to the slide 227 will swing back and forth, thereby driving the reaction tank 2 to swing, and the materials in the swing tank will be mixed. This method will not destroy the cells, thereby improving the cell storage rate.

[0028] The base 5 is provided with a through slot 20, and a swing seat 18 is slidably connected to the outer end of the through slot 20. The diameter of the swing seat 18 is larger than the diameter of the through slot 20. The base 5 is detachably connected with a guide rod 13, and a top plate 14 is slidably connected to the guide rod 13. The top plate 14 is arranged in a semicircular shape as a whole, and the two ends of the top plate 14 are connected to the tilting rod 15. Through the opening of the through slot 20, the swing seat 18 will not be restricted by the base 5 when it moves in two directions, and the swing seat 18 can swing freely and unrestricted. The top plate 14 can be restricted by the guide rod 13, and the top plate 14 can move up and down along the guide rod 13. When the top plate 14 moves up, the tilting rod 15 can be driven to rotate.

[0029] A baffle plate 11 is provided on the upper end of the guide rod 13, and the diameter of the baffle plate 11 is larger than the diameter of the guide rod 13. A first spring 12 is sleeved on the guide rod 13 between the baffle plate 11 and the top plate 14, and one end of the first spring 12 is detachably connected to the baffle plate 11, and the other end of the first spring 12 is detachably connected to the upper end surface of the top plate 14. The first spring 12 on the guide rod 13 will not be dislocated by the restriction of the baffle plate 11, and the top plate 14 can be driven to move upward when the top plate 14 is not restricted. The torsion of the first spring 12 is greater than the torsion of the third spring 25, and the top plate 14 drives the tilting rod 15 to push the seat 10 downward.

[0030] In practice, the inner cavity 21 can be opened inside the base 5 by setting the base 5, and the servo motor 224 can be installed inside the inner cavity 21. The output end of the servo motor 224 is provided with a special-shaped frame 226, and the servo motor 224 can drive the special-shaped frame 226 to rotate. One end of the special-shaped frame 226 is connected to the connecting rod 192, and the connecting rod 192 and the special-shaped frame 226 can rotate at the same time. The special-shaped frame 226 is located between the first side frame 223 and the second side frame 225 of the slide 227. When the special-shaped frame 226 rotates, it will reciprocate and push the first side frame 223. 3 and the second side frame 225, when the special-shaped frame 226 pushes the first side frame 223 and the second side frame 225, the slide 227 will reciprocate in two directions, and the swing seat 18 connected to the slide 227 can realize activities in two directions to make the rubber seat 17 swing. When the reaction tank 2 is placed on the rubber seat 17, the reaction tank 2 can swing after the upper part of the reaction tank 2 is connected with a ring. During the swinging process, the material in the reaction tank 2 can first rise and then fall due to inertia to achieve mixing. Compared with the agitator, it will not damage the cells, thereby improving the survival rate of the cells.

[0031] The bracket 6 is L-shaped as a whole, and a fixing seat 24 is fixedly connected to the side wall of the bracket 6, and a plug rod 23 is slidably connected to the fixing seat 24. The input end of the plug rod 23 is detachably connected to the mounting seat 10, and the mounting seat 10 is L-shaped as a whole, and one end of the corresponding tilting rod 15 is overlapped at the bent position of the mounting seat 10. The ring can be restricted by the bracket 6, and the ring can be rotated on the bracket 6. The plug rod 23 can be restricted by the fixing seat 24 on the bracket 6, and the plug rod 23 can be movable on the fixing seat 24. When the mounting seat 10 is connected to the plug rod 23, the mounting seat 10 can be linked with the plug rod 23.

[0032] The bottom of the cradle 10 is detachably connected with a limit rod 9, which is arranged vertically on the cradle 10 and slidably connected to the corresponding base 5. A third spring 25 is sleeved on the insertion rod 23 between the cradle 10 and the fixed seat 24, one end of the third spring 25 is detachably connected to the fixed seat 24, and the other end of the third spring 25 is detachably connected to the cradle 10. The cradle 10 can be driven to reset by the third spring 25, and the insertion rod 23 on the cradle 10 can be reset when the cradle 10 is reset.

[0033] The socket 8 is provided with a socket 16, which corresponds to the position of the plug rod 23. The plug rod 23 is parallel to the bracket 6, and the plug rod 23 is arranged along the length of the bracket 6. The plug rod 23 is cylindrical. The socket 8 can be fixed as a whole by connecting the plug rod 23 with the socket 16.

[0034] The socket 8 is provided with a socket 16, and the position of the socket 16 corresponds to the position of the plug rod 23. The plug rod 23 is parallel to the bracket 6, and the plug rod 23 is arranged along the length of the bracket 6. The plug rod 23 is cylindrical. The plug rod 23 can be inserted into the socket 16 of the socket 8, thereby fixing the socket 8.

[0035] The convex plate 191 is arranged in an arc shape as a whole, the extension rod 193 and the connecting rod 192 are arranged in an L shape as a whole, the first cross bar 194 and the second cross bar 195 are arranged vertically on the corresponding extension rod 193, and the first cross bar 194 and the second cross bar 195 are parallel to each other. The convex plate 191 can be linked with the top plate 14 by setting it. When the convex plate 191 is not restricted by the first cross bar 194 and the second cross bar 195, the top plate 14 can move upward, and when the top plate 14 moves upward, it can drive the convex plate 191 to move upward.

[0036] The swing mechanism 22 includes a servo motor 224, the input end of the servo motor 224 is detachably connected to a special-shaped frame 226, one end of the special-shaped frame 226 is detachably connected to a connecting rod 192, a sliding rod 221 is horizontally arranged in the inner cavity 21 above the special-shaped frame 226, a sliding seat 227 is slidably connected to the sliding rod 221, the sliding seat 227 is detachably connected to the swing seat 18, a first side frame 223 and a second side frame 225 are arranged at one end of the sliding seat 227, and second springs 222 of the same structure are sleeved on the sliding rods 221 on both sides of the sliding seat 227. The special-shaped frame 226 can push the first side frame 223 and the second side frame 225, and when the first side frame 223 and the second side frame 225 move, the sliding seat 227 can be driven to move in the corresponding direction, and the swing seat 18 on the sliding seat 227 can be moved, and the second spring 222 can realize the buffering of the sliding seat 227, and the sliding seat 227 can be reset by the second spring 222 when it is not driven.

[0037] The special-shaped frame 226 is arranged in a U-shape as a whole, and is located between the first side frame 223 and the second side frame 225. The first side frame 223 and the second side frame 225 are arranged in a U-shape as a whole, and one end of the second side frame 225 has an inclined protrusion. The special-shaped frame 226 can push the first side frame 223 and the second side frame 225.

[0038] During implementation, by installing the connecting rod 192 on the special-shaped frame 226, the connecting rod 192 will rotate with the drive of the servo motor 224, and the connecting rod 192 will drive the first cross bar 194 and the second cross bar 195 to move away from the convex plate 191 during rotation, and the convex plate 191 can move away from the first cross bar 194 and the second cross bar 195, and the top plate 14 can be driven by the first spring 12, and the top plate 14 can move up to push the tilting rod 15, and the tilting rod 15 will press down the seat 10 during rotation, and the seat 10 will drive the plug 23 to pull out the socket 8, and the ring can be rotated. The ring will not affect the rotation of the reaction tank 2 when limiting the position of the reaction tank 2. The ring cooperates with the swing seat 18 to achieve stable swinging of the reaction tank 2, and after the top plate 14 moves up, the convex plate 191 on the top plate 14 will move away from the first cross bar 194 and When the second cross bar 195, the first cross bar 194 and the second cross bar 195 follow the rotation, they will not hit the convex plate 191, and the convex plate 191 will not affect the rotation of the first cross bar 194 and the second cross bar 195. When the equipment stops, the special-shaped frame 226 is reset, and the personnel can be pressed on the top plate 14. After the top plate 14 is reset, the first cross bar 194 and the second cross bar 195 can be clamped on the convex plate 191 again as the special-shaped frame 226 is reset, and the convex plate 191 can be limited again, and the tilting rod 15 will not be pushed. When the tilting rod 15 does not push the seat 10, the second spring 222 will drive the seat 10 to reset. When the seat 10 is reset, the insertion rod 23 connected to the seat 10 will be inserted into the socket 8 again, the socket 8 can be fixed, the ring can be fixed, and the reaction tank 2 will no longer rotate, thereby realizing the fixation of the reaction tank 2.

[0039] The working principle of the present invention is as follows: through the arrangement of the base 5, an inner cavity 21 can be opened inside the base 5, a servo motor 224 can be installed inside the inner cavity 21, a special-shaped frame 226 is provided on the output end of the servo motor 224, the servo motor 224 can drive the special-shaped frame 226 to rotate, one end of the special-shaped frame 226 is connected to the connecting rod 192, the connecting rod 192 and the special-shaped frame 226 can rotate at the same time, the special-shaped frame 226 is located between the first side frame 223 and the second side frame 225 of the slide 227, and the special-shaped frame 226 reciprocates when rotating. When the first side frame 223 and the second side frame 225 are pushed by the special-shaped frame 226, the slide 227 will reciprocate in two directions, and the swing seat 18 connected to the slide 227 can realize activities in two directions to make the rubber seat 17 swing. When the reaction tank 2 is placed on the rubber seat 17, the reaction tank 2 can swing after the sleeve ring is connected above the reaction tank 2. During the swinging process, the material in the reaction tank 2 can first rise and then fall due to inertia to achieve mixing. Compared with the agitator, it will not damage the cells, thereby improving the survival rate of the cells.

[0040] By installing the connecting rod 192 on the special-shaped frame 226, the connecting rod 192 will rotate with the drive of the servo motor 224. The connecting rod 192 will drive the first cross bar 194 and the second cross bar 195 to move away from the convex plate 191 during rotation, and the convex plate 191 can move away from the first cross bar 194 and the second cross bar 195. The top plate 14 can be driven by the first spring 12, and the top plate 14 can move up to push the tilting rod 15. During the rotation of the tilting rod 15, the seat 10 will be pressed down, and the seat 10 will drive the plug 23 to pull out the socket 8, and the ring can be rotated. The ring will not affect the rotation of the reaction tank 2 when limiting the position of the reaction tank 2. The ring and the swing seat 18 can cooperate to achieve stable swinging of the reaction tank 2. After the top plate 14 moves up, the convex plate 191 on the top plate 14 will move away from the first cross bar 194 and the second When the cross bar 195, the first cross bar 194 and the second cross bar 195 follow the rotation, they will not hit the convex plate 191, and the convex plate 191 will not affect the rotation of the first cross bar 194 and the second cross bar 195. When the equipment stops, the special-shaped frame 226 is reset, and the personnel can be pressed on the top plate 14. After the top plate 14 is reset, the first cross bar 194 and the second cross bar 195 can be clamped on the convex plate 191 again as the special-shaped frame 226 is reset, and the convex plate 191 can be limited again, and the tilting rod 15 will not be pushed. When the tilting rod 15 does not push the seat 10, the second spring 222 will drive the seat 10 to reset. When the seat 10 is reset, the insertion rod 23 connected to the seat 10 will be inserted into the socket 8 again, the socket 8 can be fixed, the ring can be fixed, and the reaction tank 2 will no longer rotate, thereby realizing the fixation of the reaction tank 2.

[0041] The above describes the basic principles, main features and advantages of the present application. Those skilled in the art should understand that the present application is not limited by the above embodiments, and the above embodiments and the specification only describe the principles of the present application. The present application may have various changes and improvements without departing from the spirit and scope of the present application, and these changes and improvements fall within the scope of the present application for which protection is sought. The scope of protection claimed by the present application is defined by the attached claims and their equivalents.

Claims

1. A biological vaccine cell reactor, comprising a controller (1), a reaction tank (2), a servo motor (224), a liquid inlet (4) and a sampling port (3), characterized in that: The reaction tank (2) is plugged into the hoop (7); the side wall of the hoop (7) is rotatably connected to the bracket (6); the bracket (6) is fixedly connected to the base (5); an inner cavity (21) is provided inside the base (5); a swing mechanism (22) is detachably connected inside the inner cavity (21); an output end of the swing mechanism (22) is detachably and fixedly connected to a swing seat (18); a rubber seat (17) is detachably connected to the swing seat (18); the rubber seat (17) is detachably connected to the rubber seat (17); 7) is sleeved on the bottom of the reaction tank (2), the bracket (6) is slidably connected with an insertion rod (23), the insertion rod (23) is inserted into the socket (8) of the hoop (7), the input end of the insertion rod (23) is overlapped with a tilting rod (15), the tilting rod (15) is telescopically connected with a top plate (14) in the input direction, the input end of the top plate (14) is detachably connected with a release mechanism (19), and the input end of the release mechanism (19) is detachably connected to the swing mechanism (22).

2. A biological vaccine cell reactor as claimed in claim 1, characterized in that: The base (5) is provided with a through slot (20), and a swing seat (18) is slidably connected to the outer end of the through slot (20), and the diameter of the swing seat (18) is larger than the diameter of the through slot (20). The base (5) is detachably connected to a guide rod (13), and a top plate (14) is slidably connected to the guide rod (13), and the top plate (14) is arranged in a semicircular shape as a whole, and the two ends of the top plate (14) are connected to the tilting rod (15).

3. A biological vaccine cell reactor as claimed in claim 2, characterized in that: A baffle (11) is arranged on the upper end of the guide rod (13), the diameter of the baffle (11) is larger than the diameter of the guide rod (13), a first spring (12) is sleeved on the guide rod (13) between the baffle (11) and the top plate (14), one end of the first spring (12) is detachably connected to the baffle (11), and the other end of the first spring (12) is detachably connected to the upper end surface of the top plate (14).

4. A biological vaccine cell reactor as claimed in claim 1, characterized in that: The bracket (6) is arranged in an L-shape as a whole, a fixing seat (24) is fixedly connected to the side wall of the bracket (6), an insertion rod (23) is slidably connected to the fixing seat (24), a mounting seat (10) is detachably connected to the input end of the insertion rod (23), the mounting seat (10) is arranged in an L-shape as a whole, and an end of a corresponding tilting rod (15) is overlapped at the bent position of the mounting seat (10).

5. A biological vaccine cell reactor as claimed in claim 4, characterized in that: The bottom of the mount (10) is detachably connected to a limiting rod (9), the limiting rod (9) is vertically arranged on the mount (10), the limiting rod (9) is slidably connected to the corresponding base (5), a third spring (25) is sleeved on the insertion rod (23) between the mount (10) and the fixed seat (24), one end of the third spring (25) is detachably connected to the fixed seat (24), and the other end of the third spring (25) is detachably connected to the mount (10).

6. A biological vaccine cell reactor as claimed in claim 1, characterized in that: The socket (8) is provided with a socket (16), the socket (16) corresponds to the position of the insertion rod (23), the insertion rod (23) and the bracket (6) are parallel to each other, the insertion rod (23) is arranged along the length of the bracket (6), and the insertion rod (23) is cylindrical.

7. A biological vaccine cell reactor as claimed in claim 1, characterized in that: The release mechanism (19) comprises a convex plate (191), wherein the convex plate (191) is detachably connected to the side wall of the top plate (14), and the upper and lower sides of the convex plate (191) are slidably connected to a first cross bar (194) and a second cross bar (195), wherein the first cross bar (194) and the second cross bar (195) are respectively fixed to a stretching rod (193), and one end of the stretching rod (193) is detachably connected to a connecting rod (192).

8. A biological vaccine cell reactor as claimed in claim 7, characterized in that: The convex plate (191) is arranged in an arc shape as a whole, the extension rod (193) and the connecting rod (192) are arranged in an L shape as a whole, the first cross bar (194) and the second cross bar (195) are arranged vertically on the corresponding extension rod (193), and the first cross bar (194) and the second cross bar (195) are parallel to each other.

9. A biological vaccine cell reactor as claimed in claim 1, characterized in that: The swing mechanism (22) comprises a servo motor (224), the input end of the servo motor (224) is detachably connected to a special-shaped frame (226), one end of the special-shaped frame (226) is detachably connected to a connecting rod (192), a sliding rod (221) is horizontally arranged in the inner cavity (21) above the special-shaped frame (226), a sliding seat (227) is slidably connected to the sliding rod (221), the sliding seat (227) is detachably connected to the swing seat (18), a first side frame (223) and a second side frame (225) are arranged at one end of the sliding seat (227), and a second spring (222) of the same structure is sleeved on the sliding rods (221) on both sides of the sliding seat (227).

10. A biological vaccine cell reactor as claimed in claim 9, characterized in that: The special-shaped frame (226) is arranged in a U-shape as a whole. The special-shaped frame (226) is located between the first side frame (223) and the second side frame (225). The first side frame (223) and the second side frame (225) are arranged in a U-shape as a whole. One end of the second side frame (225) has an inclined protrusion.