Sample analyzer
By adjusting the structure of the sample analyzer, the first air duct is set on the right side of the reagent management component, and the functional components are installed using the rear space, the problem of excessive volume of the sample analyzer is solved, and the working efficiency and space utilization are improved.
Patent Information
- Application Number
- CN202310804208.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2023-06-30
- Publication Date
- 2024-12-31
AI Technical Summary
Due to too many functional mechanisms, existing sample analyzers have too large equipment and take up too much space, making it difficult to use in a small environment.
By optimizing the structural design of the sample analyzer, the first air duct is set on the right side of the reagent management component, and other functional components are fully utilized to install the space on the back of the reagent management component, reducing the length of the sample analyzer in the left and right directions, and improving the The efficiency of reaction cup scheduling operations.
The sample analyzer is reduced in size, improving the working efficiency and space utilization of the equipment, and is suitable for environments with smaller areas.
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Figure CN119224281A_ABST
Abstract
Description
Technical Field
[0001] The present application belongs to the field of medical equipment, and in particular, relates to a sample analyzer. Background Art
[0002] Sample analysis devices, such as biochemical immunoassay analyzers, are medical devices used to detect various analytical indicators of blood, urine or other body fluids.
[0003] In the related art, with the development of sample analysis devices, more and more functional mechanisms are integrated in the sample analysis devices. However, these numerous functional mechanisms also lead to the increasing size of the sample analysis devices, which occupy too much space. Summary of the invention
[0004] The embodiment of the present application provides a sample analyzer, which can reduce the volume of the sample analyzer.
[0005] The present application embodiment provides a sample analyzer, comprising:
[0006] Reagent management component, used for carrying reagents;
[0007] A sample management component, used for carrying samples;
[0008] An incubation component, used for incubating the reaction solution in the reaction cup, wherein the reaction solution is prepared from at least the reagent and the sample;
[0009] A measuring component, used for measuring the reaction solution after incubation;
[0010] A scheduling component, used for scheduling the reaction cups; and
[0011] A temperature control component is used to control the temperature of the reagent management component, and the temperature control component includes a first air duct connected to the reagent management component, the first air duct is located on a first side of the reagent management component along a first direction, and the sample management component is located on a second side of the reagent management component along the first direction, and the first side and the second side are opposite.
[0012] Optionally, the sample analyzer further includes a reaction liquid processing component and a reaction cup supply component, the reaction liquid processing component includes at least one of a mixing component, a magnetic separation component and the incubation component, the mixing component is used to mix the reaction liquid in the reaction cup, the magnetic separation component is used to perform magnetic separation and cleaning on the reaction liquid in the reaction cup and inject substrate, and the reaction cup supply component is used to supply the reaction cup;
[0013] Wherein, at least one of the reaction liquid processing component, the reaction cup supply component, the measuring component and the scheduling component is located on a third side of the reagent management component along a second direction, and the second direction is perpendicular to the first direction;
[0014] The sample management component includes a first end, the first end is oriented in the same direction as the fourth side of the reagent management component, the third side is opposite to the fourth side, and the first end is provided with a sample inlet for adding a sample into the sample management component.
[0015] Optionally, the sample analyzer further includes a cuvette supply component, the cuvette supply component is used to supply cuvettes, the cuvette supply component includes a hopper, the hopper is used to hold cuvettes, and the hopper is at least partially located on the upper side of the first air duct.
[0016] Optionally, the sample analyzer further includes a reaction cup supply component, which is used to supply reaction cups, and the orthographic projection of the reaction cup supply component along the first direction partially overlaps with the orthographic projection of the reagent management component along the first direction; the orthographic projection of the reaction cup supply component along the second direction partially overlaps with the orthographic projection of the reagent management component along the second direction, and the first direction and the second direction are perpendicular to each other.
[0017] Optionally, the incubation component is provided with a plurality of incubation holes, and the incubation holes are used to accommodate a reaction cup so as to incubate the reaction liquid in the reaction cup, and the plurality of incubation holes are arranged in a honeycomb shape.
[0018] Optionally, the incubation component is provided with a measurement hole, and the measurement hole is used to accommodate a reaction cup;
[0019] The measuring component is used to measure the reaction solution after incubation carried by the cuvette in the measuring hole.
[0020] Optionally, a first avoidance space is provided on a side of the incubation component facing the reagent management component, and a side of the measurement component facing away from the reagent management component is provided in the first avoidance space.
[0021] Optionally, the scheduling component is further used to schedule the reaction cup that has completed the measurement to the cup throwing position, and the sample analyzer also includes:
[0022] A reaction cup recovery component, comprising a reaction cup container and a reaction cup carrying mechanism, wherein the reaction cup container is used to receive the reaction cup dropped from the cup throwing position, and the reaction cup carrying mechanism is arranged at the cup throwing position to fix or release the reaction cup at the cup throwing position; and
[0023] The waste liquid suction component is used to suck the reaction liquid in the reaction cup located at the cup throwing position.
[0024] Optionally, a first avoidance space is provided on a side of the incubation component facing the reagent management component, and the reaction cup recovery component is at least partially disposed in the first avoidance space.
[0025] Optionally, the waste liquid suction component is at least partially located in a space enclosed by the reaction cup supply component, the measurement component and the reagent management component.
[0026] Optionally, the measuring component is used to measure the target reaction liquid carried by the reaction cup located at the measuring position, and the waste liquid suction component includes:
[0027] A first driving mechanism 1310;
[0028] a light shield, which is in driving connection with the first driving mechanism, so as to be driven by the first driving mechanism to be away from or cover the reaction cup located at the measuring position; and
[0029] The waste liquid suction needle is fixedly connected to the light shield, and the waste liquid suction needle can follow the movement of the light shield to approach or move away from the cup throwing position to suck the reaction liquid in the reaction cup located at the cup throwing position.
[0030] Optionally, the sample analyzer further includes:
[0031] A sample adding component, disposed on a side of the incubation component facing the sample management component, the sample adding component is used to carry and drive the reaction cup to move; and
[0032] A dispensing component, used for sucking a target liquid and discharging it into a reaction cup carried by the sample adding component, wherein the target liquid includes at least one of the sample carried by the sample management component and the reagent carried by the reagent management component;
[0033] The scheduling component is used to schedule the reaction cup between the reaction cup supply component, the incubation component and the sample adding component.
[0034] Optionally, the sample analyzer further includes a controller, and the controller is configured to:
[0035] Control the dispensing component to absorb the sample from the sample management component and discharge it into the first reaction cup located in the sample adding component, and control the dispensing component to absorb the first reagent from the reagent management component and discharge it into the first reaction cup located in the sample adding component, wherein the first reagent is a diluent, so that the sample is diluted to form a first intermediate reaction liquid;
[0036] Controlling the dispensing component to absorb at least a portion of the first intermediate reaction liquid from the first reaction cup;
[0037] Controlling the dispensing component to discharge the sucked first intermediate reaction liquid into the second reaction cup located in the sample adding component;
[0038] The dispensing unit is controlled to suck a second reagent from the reagent management unit and discharge the second reagent into the second reaction cup so that the second reagent is mixed with the first intermediate reaction liquid to form a second intermediate reaction liquid, and the second reagent is different from the first reagent.
[0039] In the embodiment of the present application, taking the case where the first side is the left side of the reagent management component and the second side is the right side of the reagent management component as an example, if the first air duct is set on the rear side of the reagent management component, other functional components cannot be installed on the rear side of the reagent management component, and further, other functional components of the sample analyzer need to be arranged along the left-right direction on the right side of the reagent management component, ultimately causing the sample analyzer to be too long in the left-right direction; in contrast, the embodiment of the present application sets the first air duct on the right side of the reagent management component, so that the space on the rear side of the reagent management component can be fully utilized to install other functional components, thereby avoiding the sample analyzer being too long in the left-right direction, thereby reducing the volume of the sample analyzer. BRIEF DESCRIPTION OF THE DRAWINGS
[0040] The technical solution and beneficial effects of the present application will be made apparent by describing in detail the specific implementation methods of the present application in conjunction with the accompanying drawings.
[0041] Figure 1 A schematic diagram of the structure of a sample analyzer provided in an embodiment of the present application.
[0042] Figure 2 for Figure 1 Schematic diagram of the plan layout of the sample analyzer shown.
[0043] Figure 3 for Figure 1 A schematic structural diagram of the sample analyzer from another perspective is shown.
[0044] Figure 4 for Figure 2 The schematic diagram of the structure of the throwing cup in the sample analyzer is shown.
[0045] Figure 5 for Figure 3 The schematic diagram of the structure of the throwing cup in the sample analyzer is shown.
[0046] Figure 6 for Figure 5 The schematic diagram of the structure of the reaction cup recovery component in the sample analyzer is shown.
[0047] Figure 7 for Figure 5 Another structural schematic diagram of the reaction cup recovery component in the sample analyzer is shown. DETAILED DESCRIPTION
[0048] The technical solutions in the embodiments of the present application will be described clearly and completely below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present application.
[0049] Please refer to Figure 1 , Figure 1 A schematic diagram of a sample analyzer provided in an embodiment of the present application. The present application provides a sample analyzer, which may include a reagent management component 100, a sample management component 200, an incubation component 300, a determination component 400, a scheduling component 500, and a temperature control component 600.
[0050] The reagent management component 100 is used to carry reagents. The sample management component 200 is used to carry samples. The incubation component 300 is used to incubate the reaction liquid in the reaction cup, and the reaction liquid is prepared by at least reagents and samples. The determination component 400 is used to determine the reaction liquid after incubation. The scheduling component 500 is used to schedule the reaction cup. The temperature control component 600 is used to perform temperature control on the reagent management component 100. The temperature control component 600 includes a first air duct 61 connected to the reagent management component 100. The first air duct 61 is located on the first side of the reagent management component 100 along the first direction H1, and the sample management component 200 is located on the second side of the reagent management component 100 along the first direction H1, and the first side and the second side are opposite.
[0051] Taking the case where the first side is the left side of the reagent management component 100 and the second side is the right side of the reagent management component 100 as an example, if the first air duct 61 is set on the rear side of the reagent management component 100, it will result in that other functional components cannot be installed on the rear side of the reagent management component 100, and then the other functional components of the sample analyzer need to be arranged in the left-right direction on the right side of the reagent management component 100, and finally the sample analyzer is too long in the left-right direction, and it is difficult to enter some small-area rooms. In contrast, the embodiment of the present application sets the first air duct 61 on the right side of the reagent management component 100, so that the space on the rear side of the reagent management component 100 can be fully utilized to install other functional components, thereby avoiding the sample analyzer from being too long in the left-right direction, thereby reducing the volume of the sample analyzer.
[0052] Of course, since the functional components required for the reaction cup scheduling operation are more concentrated, the sample analyzer of the embodiment of the present application can also make the reaction cup scheduling operation more efficient, thereby improving the working efficiency of the sample analyzer.
[0053] It should also be noted that, in some other embodiments, the first side may be the right side of the reagent management component 100 and the second side may be the left side of the reagent management component 100, or the first side may be the front side of the reagent management component 100 and the second side may be the rear side of the reagent management component 100, or the first side may be the rear side of the reagent management component 100 and the second side may be the front side of the reagent management component 100, and the embodiments of the present application are not limited to this.
[0054] Hereinafter, the embodiment of the present application will continue to take the first side being the right side of the reagent management component 100 and the second side being the left side of the reagent management component 100, that is, the first direction H1 being the left and right direction as an example to further explain and illustrate the technical solution of the embodiment of the present application.
[0055] The temperature control component 600 may be used only for cooling the reagent management component 100. Optionally, the temperature control component 600 may also be used only for heating the reagent management component 100. Of course, the temperature control component 600 may also be used for cooling or heating at the same time, so as to selectively cool or heat the reagent management component 100 according to factors such as the storage temperature requirements of the reagents in the reagent management component 100, which is not limited in the embodiments of the present application.
[0056] In some embodiments, the temperature control component 600 may also include a second air duct (not shown in the figure), and the second air duct is connected to the reagent management component 100. The second air duct is located at the lower side of the reagent management component 100. Furthermore, the temperature control component 600 can exchange heat with the outside of the sample analyzer through the first air duct 61 and the second air duct. At the same time, since the first air duct 61 is arranged at the lower side of the reagent management component 100, more space can be reserved on the work surface of the sample analyzer to install functional components that need to perform reaction cup scheduling operations, and then the sample analyzer can be provided with a scheduling component 500 with a smaller stroke to schedule the reaction cup, and finally the volume of the scheduling component 500 and the entire sample analyzer can be smaller.
[0057] Of course, since the functional components required for the reaction cup scheduling operation are more concentrated, the sample analyzer of the embodiment of the present application can also make the reaction cup scheduling operation more efficient, thereby improving the working efficiency of the sample analyzer.
[0058] It can also be understood that, since both the first air duct 61 and the second air duct are connected to the reagent management component 100, one of the first air duct 61 and the second air duct can be an air inlet duct and the other can be an air outlet duct, so that the air outside the sample analyzer can flow into the reagent management component 100 from the air inlet duct, and then the air in the reagent management component 100 is discharged to the outside of the sample analyzer from the air outlet duct.
[0059] When one of the first air duct 61 and the second air duct is an air inlet duct and the other is an air outlet duct, at least one of the first air duct 61 and the second air duct may be provided with a fan. Thus, the fan drives the air to flow through the first air duct 61, the reagent management component 100, and the second air duct. In this case, the temperature control component 600 can cool the reagent management component 100 only by driving the air flow with the fan.
[0060] Of course, the temperature control component 600 may also include a heat exchanger such as a heating wire, an evaporator, a condenser, and the like.
[0061] When the temperature control component 600 includes the first air duct 61, a heat exchanger may be provided in at least one of the first air duct 61 and the reagent management component 100. For example, a heat exchanger may be provided only in the first air duct 61, or only in the reagent management component 100, or both in the first air duct 61 and the reagent management component 100.
[0062] When the refrigeration component includes the first air duct 61 and the second air duct, at least one of the first air duct 61, the reagent management component 100 and the second air duct may be provided with a heat exchanger. For example, one of the first air duct 61, the reagent management component 100 and the second air duct may be provided with a heat exchanger, or two of the first air duct 61, the reagent management component 100 and the second air duct may be provided with a heat exchanger, or the first air duct 61, the reagent management component 100 and the second air duct may all be provided with a built-in heat exchanger, which is not limited in the embodiments of the present application.
[0063] Of course, in some other implementations, the temperature control component 600 may not be provided with a second air duct, and this embodiment of the present application does not limit this.
[0064] In some embodiments, the reagent management component 100 may include a reagent pot 11 and a first turntable 12 disposed in the reagent pot 11. The first turntable 12 is provided with a plurality of reagent positions, and the reagent positions are used to carry reagents.
[0065] Then, the first air duct 61 of the temperature control component 600 may be connected to the reagent pot 11. When the temperature control component 600 further includes a second air duct, the second air duct may also be connected to the reagent pot 11.
[0066] The above are some examples of the refrigeration components in the embodiments of the present application. The following will continue to illustrate the overall layout of some components in the sample analyzer in the embodiments of the present application.
[0067] Please continue to refer to Figure 2 , Figure 2 for Figure 1The sample analyzer also includes a reaction liquid processing component and a reaction cup supply component 700 .
[0068] The reaction liquid processing part includes at least one of a mixing part 800, a magnetic separation part 900 and an incubation part 300. The mixing part 800 is used to mix the reaction liquid in the reaction cup, and the magnetic separation part 900 is used to perform magnetic separation and cleaning on the reaction liquid in the reaction cup and inject the substrate. The reaction cup supply part 700 is used to supply the reaction cup.
[0069] That is to say, the reaction liquid processing component may only include the above-mentioned mixing component 800, the reaction liquid processing component may only include the magnetic separation component 900, the reaction liquid processing component may only include the incubation component 300, the reaction liquid processing component may only include the mixing component 800 and the magnetic separation component 900, the reaction liquid processing component may only include the magnetic separation and incubation component 300, and the reaction liquid processing component may also include the mixing component 800, the magnetic separation component 900 and the incubation component 300 at the same time, and the embodiments of the present application are not limited to this.
[0070] In some embodiments, at least one of the reaction solution processing unit, the cuvette supply unit 700, the determination unit 400, and the scheduling unit 500 is located on a third side of the reagent management unit 100 along the second direction H2. The second direction H2 is perpendicular to the first direction H1.
[0071] That is, among the reaction liquid processing part, the cuvette supply part 700, the measuring part 400 and the scheduling part 500, only the reaction liquid processing part may be located on the third side of the reagent management part 100, only the cuvette supply part 700 may be located on the third side of the reagent management part 100, only the measuring part 400 may be located on the third side of the reagent management part 100, only the reaction liquid processing part and the cuvette supply part 700 may be located on the third side of the reagent management part 100, only the reaction liquid processing part and the measuring part 400 may be located on the third side of the reagent management part 100, and only the reaction liquid processing part and the scheduling part 500 may be located on the third side of the reagent management part 100. It is possible that only the reaction liquid processing component, the reaction cup supply component 700 and the measurement component 400 are located on the third side of the reagent management component 100, only the reaction cup supply component 700 and the measurement component 400 are located on the third side of the reagent management component 100, only the reaction cup supply component 700 and the measurement component 400 are located on the third side of the reagent management component 100, only the reaction cup supply component 700 and the scheduling component 500 are located on the third side of the reagent management component 100, only the reaction cup supply component 700, the measurement component 400 and the scheduling component 500 are located on the third side of the reagent management component 100, or the reaction liquid processing component, the reaction cup supply component 700, the measurement component 400 and the scheduling component 500 are all located on the third side of the reagent management component 100, and the embodiment of the present application is not limited to this.
[0072] Continuing with the example that the first side is the left side of the reagent management component 100 and the second side is the right side of the reagent management component 100, the third side can be the rear side of the reagent management component 100. In the embodiment of the present application, by installing functional components such as the reaction liquid processing component, the reaction cup supply component 700, the measurement component 400 and the scheduling component 500 on the rear side of the reagent management component 100, the space on the rear side of the reagent management component can be fully utilized. Compared with distributing these components in other locations in a scattered manner, the structure of the sample analyzer can be more compact and smaller in size.
[0073] Of course, when the functional components such as the reaction liquid processing component, the reaction cup supply component 700 and the measurement component 400 that require the scheduling component 500 to perform reaction cup scheduling operations are concentrated on the back side of the reagent management component 100, the reagent management component 100, the sample management component 200 and the functional components that require reaction cup scheduling can be closer and more concentrated, so that the sample analyzer can use the scheduling component 500 with a smaller stroke and smaller size to schedule the reaction cup, so as to make the structure of the sample analyzer more compact and smaller in size.
[0074] In addition, since the functional components required for the reaction cup scheduling operation are more concentrated, the sample analyzer of the embodiment of the present application can also make the reaction cup scheduling operation more efficient, thereby improving the working efficiency of the sample analyzer.
[0075] In some embodiments, the sample management component 200 includes a first end. The first end is oriented in the same direction as the fourth side of the reagent management component 100. The third side and the fourth side are opposite. The first end is provided with a sample inlet, and the sample inlet is used to add a sample into the sample management component 200.
[0076] Then, continuing to take the example that the third side is the rear side of the reagent management component 100, the fourth side is the front side of the reagent management component 100. That is, the first end of the sample management component 200 is the front end of the sample management component 200, so at this time, the front side of the sample analyzer can also be understood as the operation side of the sample analyzer, so that the user can easily put the sample into the sample management component 200 from the front side.
[0077] Exemplarily, the sample management component 200 may include an injection channel 21, a code scanning channel 22 and a sample suction channel 23. The sample management component 200 also includes a sample scheduling mechanism and a sample code scanning mechanism. The entrance of the injection channel 21 is located at the first end to form the above-mentioned sample entrance. Thus, the user can put the sample into the injection channel 21 from the sample entrance, such as, the user can put a sample rack carrying a plurality of sample tubes into the sample entrance, each sample tube carrying a sample. The sample scheduling mechanism is used to schedule the sample rack between the injection channel 21, the code scanning channel 22 and the sample suction channel 23. The sample code scanning mechanism is used to scan the barcodes of the sample rack and / or sample tubes in the code scanning channel 22.
[0078] Then, the sample management component 200 can first transfer the sample rack placed by the user to the code scanning channel 22 for the sample code scanning component to perform the code scanning operation, and then continue to transfer the sample rack to the sample suction channel 23 for other components to suck the sample, so that the sample analyzer can detect the information of the sample sucked by other components.
[0079] In some embodiments, the sample analyzer further includes a reserved area 1000, which is located on a side of the sample management component 200 away from the first end. The reserved area 1000 can be used to install a display screen, etc., so that the user can select different functional components on the rear side of the sample management component 200 according to actual needs, so as to avoid wasting the area on the rear side of the sample management component 200.
[0080] Continuing with the example of the sample analyzer including the magnetic separation component 900, the sample analyzer may further include a substrate delivery component 1100, which is used to deliver the substrate. The substrate delivery component 1100 may be connected to the magnetic separation component 900 through a liquid path component, so that the user can inject the substrate from the substrate delivery component 1100 into the reaction cup carried by the magnetic separation component 900.
[0081] The substrate placing component 1100 may be located between the first end of the sample management component 200 and the reagent management component 100. Therefore, it can also be understood that the substrate placing component 1100 is also located at the front side of the sample analyzer, so that the user can operate from the front side of the sample analyzer.
[0082] In some embodiments, the reagent management component 100 can be configured to be able to put in reagents from the fourth side. Then, the user can manually put in the substrate, sample and reagent from the front side, and after the sample analyzer is loaded with the substrate, sample and reagent, each functional component can automatically perform the corresponding operation on the back side. It can be seen that the sample analyzer of the embodiment of the present application integrates the functional components required for the reaction cup scheduling operation on the back side to reduce the volume, and can also avoid mutual interference between the functional components of the sample analyzer and the user, so as to improve the reliability and efficiency of the sample analyzer.
[0083] In order to provide a better user experience, the direction of the opening of the end of the first air duct 61 away from the reagent management component 100 is the same as the direction of the third side of the reagent management component 100. In other words, the opening of the end of the first air duct 61 away from the reagent management component 100 is backward. Then, on the one hand, it can prevent the first air duct 61 from being blocked when the user operates at the front side; on the other hand, taking the temperature control component 600 as an example for exhausting hot air, the outlet of the first air duct 61 facing backward can prevent the hot air from blowing towards the user at the front side, thereby improving the user experience.
[0084] In some embodiments, the reagent management component 100 may further include a reagent code scanning mechanism 13 , and the reagent code scanning mechanism 13 is used to identify information of the reagent carried by the reagent management component 100 .
[0085] For example, the reagent management component 100 includes a reagent pot 11 and a first turntable 12 disposed in the reagent pot 11. Then the reagent code scanning mechanism 13 can be disposed on the fourth side or the front side of the reagent pot 11 to scan and identify the reagent carried on the reagent position of the first turntable 12.
[0086] Next, the technical solution of the embodiment of the present application will be described by taking the sample analyzer including the cuvette supply component 700, where the cuvette supply component 700 is used to supply cuvettes as an example.
[0087] The cuvette supply component 700 may include a hopper 71. The hopper 71 is used to hold cuvettes. Therefore, the user can conveniently pour batches of cuvettes into the hopper 71 without the user having to stack the batches of cuvettes in order in advance and then put them into the cuvette supply component 700, thereby improving the user experience.
[0088] In some embodiments, the hopper 71 is at least partially located on the upper side of the first air duct 61. That is, the hopper 71 can be completely disposed on the upper side of the first air duct 61, or the hopper 71 can be only partially disposed on the upper side of the first air duct 61, and the embodiment of the present application does not limit this. Furthermore, the embodiment of the present application can also be understood as using the space on the upper side of the first air duct 61 to load the reaction cup, so that the overall structure of the sample analyzer is more compact and occupies a smaller area.
[0089] In some embodiments, the reaction cup supply component 700 may further include a picking mechanism 72, a conveying track 73, and a second turntable 74. The picking mechanism 72 is used to pick up the reaction cup in the hopper 71 to the first preset position. One end of the conveying track 73 is located at the first preset position to receive the reaction cup picked up by the picking mechanism 72 to the first preset position. The other end of the conveying track 73 is connected to the second turntable 74 so that the reaction cup in the conveying track 73 can slide into the second turntable 74. The second turntable 74 is used to carry the reaction cup and rotate the reaction cup to the cup grabbing position for the scheduling component 500 to grab. In this way, the reaction cup supply component 700 can complete the supply operation of the reaction cup.
[0090] In actual operation, the picking mechanism 72 can be used to pick up the reaction cup in the hopper 71 and move the reaction cup to the first preset position in a preset posture. For example, the picking mechanism 72 can be used to move the reaction cup to the first preset position with the cup mouth facing down, the cup mouth facing down, the cup mouth facing left, or the cup mouth facing right.
[0091] In some embodiments, the orthographic projection of the cuvette supply component 700 along the first direction H1 partially overlaps with the orthographic projection of the reagent management component 100 along the first direction H1. The orthographic projection of the cuvette supply component 700 along the second direction H2 partially overlaps with the orthographic projection of the reagent management component 100 along the second direction H2, and the first direction H1 and the second direction H2 are perpendicular to each other.
[0092] For example, the reagent management component 100 is a circular structure. Then the cuvette supply component 700 can be understood to be located at the right rear side of the reagent management component 100, and the distance between the cuvette supply component 700 and the reagent management component 100 is very small, so that the orthographic projections of the cuvette supply component 700 and the reagent management component 100 in the left-right direction and the front-back direction partially overlap. Based on the small distance between the cuvette supply component 700 and the reagent management component 100, the sample analyzer can be more compact and smaller in size.
[0093] Exemplarily, in combination with the above-mentioned reaction cup supply component 700, the reaction cup supply component 700 includes a hopper 71, a picking mechanism 72, a conveying track 73, and a second turntable 74. Then, the orthographic projection of the hopper 71 along the first direction H1 may partially overlap with the orthographic projection of the reagent management component 100 along the first direction H1, the orthographic projection of the hopper 71 along the second direction H2 may partially overlap with the orthographic projection of the reagent management component 100 along the second direction H2, and the picking mechanism 72, the conveying track 73, and the second turntable 74 are located on one side of the reagent management component 100 along the second direction H2.
[0094] The above are some examples of the reaction cup supply component 700 in the embodiment of the present application. The following will continue to illustrate the optional structure of the incubation component 300 in the implementation of the present application.
[0095] Please continue to refer to Figure 3 and Figure 4 , Figure 3 for Figure 1 The schematic diagram of the structure of the sample analyzer from another perspective is shown. Figure 4 for Figure 2 The schematic diagram of the structure of the cup throwing part in the sample analyzer is shown. The incubation part 300 is provided with a plurality of incubation holes 31, which are used to accommodate the reaction cup to incubate the reaction liquid in the reaction cup, and the plurality of incubation holes 31 are arranged in a honeycomb shape. Furthermore, through the honeycomb arrangement, the incubation part 300 can be provided with the same number of incubation holes 31 in a smaller volume, thereby reducing the volume of the incubation part 300, and further reducing the volume of the entire sample analyzer.
[0096] Specifically, multiple rows of incubation holes 31 can be arranged along the second direction H2, each row of incubation holes 31 includes multiple incubation holes 31 arranged along the first direction H1, and the incubation holes 31 in two adjacent rows are staggered in the first direction H1. Alternatively, it can also be understood that the incubation component 300 includes multiple rows of incubation holes 31 arranged from front to back, the incubation holes 31 in the same row are arranged left to right, and the incubation holes 31 in two adjacent rows are staggered left to right, thereby forming a denser honeycomb hexagonal arrangement structure.
[0097] In some embodiments, the incubation part 300 is further provided with a measuring hole 32. The measuring hole 32 is used to accommodate a reaction cup. The measuring part 400 is used to measure the reaction liquid after incubation carried by the reaction cup in the measuring hole 32. Therefore, it can also be understood that the measuring position of the sample analyzer is integrated on the incubation part 300. Furthermore, on the one hand, the overall volume of the sample analysis can be reduced, and on the other hand, the travel of the reaction cup from the incubation position to the measuring position for measurement can be reduced, thereby improving the working efficiency of the sample analyzer.
[0098] In some embodiments, a first escape space 33 is provided on a side of the incubation component 300 facing the reagent management component 100 , and a side of the measurement component 400 facing away from the reagent management component 100 is provided in the first escape space 33 .
[0099] Specifically, if the incubation part 300 is completely arranged on the side of the measuring part 400 away from the reagent management part 100, then the incubation part 300, the reagent management part 100 and the measuring part 400 will be surrounded to form a large space that is wasted. In contrast, in the embodiment of the present application, it can also be understood that a part of the incubation part 300 is protruded toward the reagent management part 100 from the end of the measuring part 400 away from the reagent management part 100, so that the gap between the incubation part 300, the reagent management part 100 and the measuring part 400 is smaller, so as to improve the space utilization of the sample analyzer and ultimately reduce the volume of the sample analyzer.
[0100] In some embodiments, the measuring component 400 at least partially overlaps with the reagent management component 100 in the vertical direction. For example, one end of the measuring component 400 is located at the lower side of the reagent management component 100, such as the reagent pot 11, so that the measuring component 400 can be installed in the space under the reagent pot 11 to further reduce the volume of sample analysis.
[0101] In some embodiments, the measuring component 400 can be fitted with the incubation component 300, so that on the one hand, the measuring component 400 can measure the reaction cup in the measuring hole 32, and on the other hand, the reagent management component 100, the measuring component 400 and the incubation component 300 can be more compact as a whole to reduce the volume of the sample analyzer.
[0102] In some embodiments, the sample analyzer further includes a reaction cup recovery component 1200 and a waste liquid suction component 1300. The reaction cup recovery component 1200 is used to recover the reaction cup that has been measured. The waste liquid suction component 1300 is used to suck the reaction liquid or waste liquid in the reaction cup that has been measured, thereby realizing the automatic classification and recovery of solid waste and liquid waste.
[0103] Please continue to refer to Figure 5 , Figure 5 for Figure 3 A schematic diagram of the structure of the cup throwing position in the sample analyzer shown. In some embodiments, the scheduling component 500 is used to schedule the reaction cup that has completed the measurement to the cup throwing position, such as scheduling it from the measurement hole 32 to the cup throwing position. Correspondingly, the reaction cup recovery component 1200 includes a reaction cup container 1210 and a reaction cup carrying mechanism 1220. The reaction cup container 1210 is used to receive the reaction cup that falls from the cup throwing position. The reaction cup carrying mechanism 1220 is provided at the cup throwing position to fix or loosen the reaction cup located at the cup throwing position. The waste liquid suction component 1300 is used to suck the reaction liquid in the reaction cup located at the cup throwing position.
[0104] Then, when the scheduling component 500 schedules the reaction cup after the measurement to the cup throwing position, the reaction cup carrying mechanism 1220 can first carry the reaction cup, and then the waste liquid suction component 1300 sucks away the tested reaction liquid or waste liquid in the reaction cup, and finally the reaction cup carrying mechanism 1220 releases the reaction cup at the cup throwing position so that the reaction cup falls into the reaction cup container 1210. It can be seen that the embodiment of the present application can complete the two actions of sucking waste liquid and throwing the reaction cup into the reaction cup container 1210 at the same workstation, i.e., the cup throwing position. Compared with setting an additional waste liquid suction position for the waste liquid suction component 1300 to suck waste liquid, the embodiment of the present application can reduce the number of workstations on the sample analyzer, thereby reducing the volume of the sample analyzer.
[0105] Of course, the embodiment of the present application can also reduce the distance that the reaction cup needs to move during the recovery process by completing the two actions of sucking waste liquid and throwing the reaction cup into the reaction cup container 1210 at the same workstation, thereby improving the efficiency of the sample analyzer.
[0106] In some embodiments, the reaction cup carrying mechanism 1220 may include a supporting component 1221 and a driving component 1222. The driving component 1222 is in transmission connection with the supporting component 1221. The driving component 1222 can drive the supporting component 1221 to carry the reaction cup located at the cup throwing position, and the driving component 1222 can drive the supporting component 1221 to release the reaction cup located at the cup throwing position, so that the reaction cup falls into the reaction cup container 1210.
[0107] The reaction cup container 1210 includes a recovery channel opening toward the cup throwing position, so that the reaction cup at the cup throwing position can fall directly into the recovery channel under the action of gravity.
[0108] Please continue to refer to Figure 6 and Figure 7 , Figure 6 for Figure 5 The schematic diagram of the structure of the reaction cup recovery component in the sample analyzer shown in FIG. Figure 7 for Figure 5 Another structural schematic diagram of the reaction cup recovery component in the sample analyzer shown. The supporting assembly 1221 may include a bracket 12211 and a baffle 12212. The bracket 12211 includes a first supporting portion 12211a located at the cup throwing position. The baffle 12212 includes a second supporting portion 12212a located at the cup throwing position. The baffle 12212 is transmission-connected to the driving assembly 1222. Among them, the driving assembly 1222 can drive the second supporting portion 12212a to move relative to the first supporting portion 12211a to clamp or release the reaction cup located at the cup throwing position. Furthermore, the supporting assembly 1221 can support the reaction cup located at the cup throwing position by clamping.
[0109] Next, the technical solution of the embodiment of the present application is further explained and illustrated in conjunction with one of the working processes of the supporting component 1221:
[0110] In the first step, the driving assembly 1222 drives the baffle 12212 to move to a clamping state relative to the bracket 12211.
[0111] In the second step, the scheduling component 500 schedules the measured cuvette to move to the cuvette throwing position, so that the measured cuvette is clamped by the baffle 12212 and the bracket 12211 .
[0112] In the third step, after the scheduling component 500 moves to another position for evacuation, the waste liquid suction component 1300 sucks away the reaction liquid in the reaction cup clamped by the supporting component 1221 .
[0113] In the fourth step, the waste liquid suction component 1300 is reset, and the driving assembly 1222 drives the baffle 12212 to move to an open state relative to the bracket 12211, so that the reaction cup at the cup throwing position falls into the reaction cup container 1210.
[0114] Finally, the recycling of batch reaction cups can be completed by repeating the first to fourth steps mentioned above.
[0115] It can also be understood that, in the actual operation of the sample analyzer, the first step and the second step can be performed simultaneously, that is, the scheduling component 500 schedules the measured reaction cup to the cup throwing position while the driving component 1222 drives the baffle 12212 to move to the clamping state. The first step and the second step can also be in the opposite order, that is, the scheduling component 500 schedules the measured reaction cup to the cup throwing position before the driving component 1222 drives the baffle 12212 to move to the clamping state, which is not limited in the embodiment of the present application.
[0116] In some embodiments, the baffle 12212 further includes a pusher 12212b. The pusher 12212b is connected to the second supporting portion 12212a, so that when the second supporting portion 12212a moves to release the reaction cup at the cup throwing position, the pusher 12212b moves to push the reaction cup at the cup throwing position away from the first supporting portion 12211a. Thus, when the second supporting portion 12212a releases the reaction cup from the first supporting portion 12211a, the reaction cup can be prevented from being retained on the first supporting portion 12211a, thereby causing the reaction cup at the cup throwing position to be unable to be recovered normally.
[0117] For example, in the actual operation process, after the waste liquid suction component 1300 sucks away the waste liquid in the reaction cup at the cup throwing position, the reaction cup may be adsorbed on the first supporting part 12211a due to static electricity and other reasons, resulting in the reaction cup still unable to fall into the reaction cup container 1210 normally after the second supporting part 12212a releases the reaction cup.
[0118] In addition, in the actual operation process, it may also be due to the presence of some annular protrusions in the middle of the outer wall of the reaction cup or at the cup mouth, so after the second supporting part 12212a releases the reaction cup, the annular protrusion of the reaction cup is stuck on the first supporting part 12211a and cannot fall off. It may also be due to the excessive clamping force of the first supporting part 12211a and the second supporting part 12212a on the reaction cup, so after the second supporting part 12212a releases the reaction cup, the reaction cup is still adhered to the first supporting part 12211a. Of course, it may also be that the above two or three factors work together to cause the reaction cup to remain on the first supporting part 12211a after the second supporting part 12212a releases the reaction cup, and the embodiment of the present application can well prevent the reaction cup from being retained on the first supporting part 12211a through the pushing member 12212b, thereby improving the reliability of the sample analyzer when recovering the reaction cup.
[0119] It can also be understood that, compared with the pusher 12212b and the baffle 12212 being driven by different power sources respectively, in the embodiment of the present application, the pusher 12212b is arranged on the second supporting portion 12212a so that the pusher 12212b and the baffle 12212 can share a driving assembly 1222, thereby reducing the power source on the sample analyzer and ultimately making the volume of the sample analyzer smaller.
[0120] Next, some optional structures of the pusher 12212 b will be further explained and illustrated in conjunction with one of the ways in which the baffle 12212 and the bracket 12211 cooperate to clamp or release the reaction cup.
[0121] The baffle 12212 can move toward a direction approaching the first supporting portion 12211a so that the first supporting portion 12211a and the second supporting portion 12212a cooperate to clamp the reaction cup located at the cup throwing position, and the driving assembly 1222 can drive the second supporting portion 12212a to move toward a direction away from the first supporting portion 12211a so that the reaction cup located at the cup throwing position can fall.
[0122] At this time, the baffle 12212 also includes a first connecting portion 12212c. The first connecting portion 12212c includes a third end and a fourth end that are arranged opposite to each other. The third end is connected to the second supporting portion 12212a, the fourth end is located on a side of the first supporting portion 12211a away from the second supporting portion 12212a, and the second end is fixedly connected to the pushing member 12212b.
[0123] Then, when the second supporting portion 12212a approaches the first supporting portion 12211a to clamp the reaction cup, the pusher 12212b can follow the second supporting portion 12212a to move synchronously, so that the pusher 12212b moves away from the first supporting portion 12211a to avoid the position. And, when the second supporting portion 12212a moves away from the first supporting portion 12211a to release the reaction cup, the pusher 12212b can follow the second supporting portion 12212a to move synchronously to the first supporting portion 12211a, so that the pusher 12212b pushes the reaction cup away from the first supporting portion 12211a.
[0124] Among them, the pushing member 12212b can be integrally formed with the baffle 12212; for example, the pushing member 12212b and the baffle 12212 can be integrally formed by injection molding, die casting, sheet metal processing, CNC (Computer numerical control, CNC machine tool) processing, etc.
[0125] Alternatively, the pusher 12212b may be formed separately from the baffle 12212. Thus, a suitable pusher 12212b may be selected according to actual needs. For example, the pusher 12212b may be detachably mounted on the baffle 12212 by means of screw connection, card connection, plug-in connection, etc. Alternatively, the pusher 12212b may be mounted on the baffle 12212 by means of non-detachable means such as welding or fusion.
[0126] In some embodiments, the first supporting portion 12211a is provided with a first avoidance groove 12211b for the pusher 12212b to move. Thus, on the one hand, the probability of the pusher 12212b interfering with the first supporting portion 12211a during its movement can be reduced; on the other hand, the first avoidance groove 12211b can be used to limit and guide the movement of the pusher 12212b to a certain extent, thereby preventing the pusher 12212b from being unable to accurately push the reaction cup off the first supporting portion 12211a.
[0127] The above is an example description of some optional structures of the pusher 12212b in the embodiment of the present application. Next, some other optional structures of the embodiment of the present application will be described with examples.
[0128] The bracket 12211 may also be provided with a limiting member 12211c. The limiting member 12211c is located at a side of the cup throwing position away from the first supporting portion 12211a, so as to limit the reaction cup located at the cup throwing position from moving along with the second supporting portion 12212a.
[0129] For example, in the actual operation process, after the waste liquid suction component 1300 sucks away the waste liquid in the reaction cup at the cup throwing position, the reaction cup may be adsorbed on the second supporting part 12212a due to static electricity and other reasons, resulting in the reaction cup still unable to fall into the reaction cup container 1210 normally after the first supporting part 12211a and the second supporting part 12212a release the reaction cup.
[0130] In addition, in the actual operation process, it may be that there are some annular protrusions in the middle of the outer wall of the reaction cup or at the cup mouth, so after the first supporting part 12211a and the second supporting part 12212a release the reaction cup, the annular protrusion of the reaction cup is stuck on the second supporting part 12212a. It may also be that the clamping force of the first supporting part 12211a and the second supporting part 12212a on the reaction cup is too large, so after the first supporting part 12211a and the second supporting part 12212a release the reaction cup, the reaction cup is still adhered to the second supporting part 12212a. Of course, it is also possible that two or three of the above factors work together to cause the reaction cup to remain on the second supporting part 12212a after the first supporting part 12211a and the second supporting part 12212a release the reaction cup. The limiting member 12211c can effectively prevent the reaction cup from remaining on the second supporting part 12212a, thereby improving the reliability of the sample analyzer in recovering the reaction cup.
[0131] Among them, the limiting member 12211c can be integrally formed with the bracket 12211; for example, the limiting member 12211c and the bracket 12211 can be integrally formed by injection molding, die casting, sheet metal processing, CNC processing, etc.
[0132] Alternatively, the stopper 12211c may be formed separately from the bracket 12211. Thus, a suitable stopper 12211c may be selected according to actual needs. For example, the stopper 12211c may be detachably mounted on the bracket 12211 by means of screw connection, snap connection, plug-in connection, etc. Alternatively, the stopper 12211c may be mounted on the bracket 12211 by means of non-detachable means such as welding or fusion, which is not limited in the embodiments of the present application.
[0133] The baffle 12212 is provided with a second avoidance groove 12212d, and an opening is provided at one end of the second avoidance groove 12212d facing the first supporting portion 12211a, so that the limiting member 12211c can enter or leave the second avoidance groove 12212d from the opening. Furthermore, on the one hand, the probability of the limiting member 12211c interfering with the second supporting portion 12212a during movement can be reduced; on the other hand, the movement of the baffle 12212 can be limited and guided to a certain extent by the cooperation between the second avoidance groove 12212d and the limiting member 12211c, thereby improving the movement accuracy of the baffle 12212.
[0134] The driving assembly 1222 can drive the baffle 12212 to move by means of a connecting rod, a gear rack, a synchronous pulley, etc., and this embodiment of the present application is not limited to this.
[0135] The above is an illustrative description of some optional structures for the supporting assembly 1221 to clamp or release the reaction cup in the embodiment of the present application.
[0136] It can also be understood that, in some other embodiments, the supporting component 1221 can also be an adsorption component for supporting the reaction cup located at the cup throwing position by adsorption.
[0137] For example, the supporting component 1221 may be a vacuum adsorption component, and the driving component 1222 may be a pump body component, and the vacuum adsorption component may be driven by the pump body component to adsorb or release the reaction cup.
[0138] Alternatively, the supporting component 1221 may be an electromagnetic adsorption component, and the driving component 1222 may be a power supply component, and the power supply component may supply power to or cut off power to the electromagnetic adsorption component to achieve adsorption or release of the reaction cup. It is understandable that the supporting component 1221 may carry and release the reaction cup at the cup throwing position in various ways, and the present application embodiment does not limit this.
[0139] Please continue to combine Figure 2 and Figure 4 A first avoidance space 33 is provided on one side of the incubation component 300 facing the reagent management component 100 . The reaction cup recovery component 1200 is at least partially disposed in the first avoidance space 33 .
[0140] Specifically, if the incubation part 300 is completely arranged on the side of the reaction cup recovery part 1200 away from the reagent management part 100, then the incubation part 300, the reagent management part 100 and the reaction cup recovery part 1200 will enclose a large space that is wasted. In contrast, the embodiment of the present application can also be understood as that a part of the incubation part 300 is protruded toward the reagent management part 100 from the end of the reaction cup recovery part 1200 away from the reagent management part 100, so that the gap between the incubation part 300, the reagent management part 100 and the reaction cup recovery part 1200 is smaller, so as to improve the space utilization of the sample analyzer and ultimately reduce the volume of the sample analyzer.
[0141] In some embodiments, the cuvette recovery component 1200 may be attached to at least one of the incubation component 300 , the determination component 400 , and the reagent management component 100 .
[0142] For example, the reaction cup recovery part 1200, the incubation part 300 and the determination part 400 are mutually attached, and the reagent management part 100 and the determination part 400 are mutually attached, so that the reaction cup recovery part 1200, the incubation part 300 and the determination part 400 are more compactly arranged at the rear side of the reagent management part 100 to reduce the overall volume of the sample analyzer. In addition, the path for the reaction cup to move to incubate, determine and throw the cup in sequence can be shortened, so that the working efficiency of the sample analyzer is higher.
[0143] In some embodiments, the measuring component 400 is used to measure the target reaction liquid carried by the reaction cup located at the measuring position. The waste liquid suction component 1300 may include a first driving mechanism 1310, a light shield 1320 and a waste liquid suction needle 1330. The light shield 1320 is connected to the first driving mechanism 1310 in a transmission manner so as to be driven by the first driving mechanism 1310 to move away from or cover the reaction cup located at the measuring position. The waste liquid suction needle 1330 is fixedly connected to the light shield 1320, and the waste liquid suction needle 1330 can follow the movement of the light shield 1320 and move close to or away from the cup throwing position to absorb the reaction liquid in the reaction cup located at the cup throwing position.
[0144] Specifically, the first driving mechanism 1310 can drive the waste liquid suction needle 1330 and the light shield 1320 to rise and fall synchronously. Then, when the waste liquid suction needle 1330 descends to the cup throwing position to suck the waste liquid in the reaction cup, the light shield 1320 can move to cover the reaction cup positioned at the side; when the waste liquid suction needle 1330 rises and resets, the light shield 1320 can also rise and reset synchronously.
[0145] That is to say, the waste liquid suction needle 1330 and the light shield 1320 can share a driving mechanism, thereby reducing the power source required by the sample analyzer and further reducing the size of the sample analyzer.
[0146] Continuing with the above-mentioned incubation part 300, a measuring hole 32 may be provided, and the side positioning may be located at the measuring hole 32, or it may be understood that the measuring hole 32 is the side positioning.
[0147] In some embodiments, the waste liquid suction unit 1300 is at least partially located in the space formed by the cuvette supply unit 700, the measurement unit 400 and the reagent management unit 100, so as to fully utilize the narrow space formed by the cuvette supply unit 700, the measurement unit 400 and the reagent management unit 100.
[0148] For example, in combination with the above-mentioned circular reagent management component 100, the reaction cup management component may include the above-mentioned hopper 71, picking mechanism 72, conveying track 73 and second turntable 74. For example, the first driving mechanism 1310 of the waste liquid suction component 1300 is located on the side of the hopper 71 close to the sample management component 200 along the first direction H1, or the first driving mechanism 1310 is located on the left side of the hopper 71. The conveying track 73 and the second turntable 74 are located on the side of the first driving mechanism 1310 away from the reagent management component 100 along the second direction H2, or the conveying track 73 and the second turntable 74 are located on the rear side of the first driving mechanism 1310.
[0149] The above is an example description of the relevant structure at the cup throwing position in the embodiment of the present application. The following is an example description of the structure of the sample analyzer in the embodiment of the present application for adding samples and reagents into the reaction cup.
[0150] The sample analyzer may further include a sample adding component 1400 and a dispensing component 1500 .
[0151] The sample adding part 1400 is arranged on the side of the incubation part 300 facing the sample management part 200. The sample adding part 1400 is used to carry and drive the reaction cup to move. The dispensing part 1500 is used to absorb the target liquid and discharge it into the reaction cup carried by the sample adding part 1400, and the target liquid includes at least one of the sample carried by the sample management part 200 and the reagent carried by the reagent management part 100. Among them, the scheduling part 500 is used to schedule the reaction cup between the reaction cup supply part 700, the incubation part 300 and the sample adding part 1400.
[0152] Exemplarily, the dispensing component 1500 may include a second driving mechanism and a sample suction needle. The second driving mechanism is installed and fixed between the reagent management component 100 and the sample management component 200. The second driving mechanism is used to drive the sample suction needle to move between the sample management component 200, the reagent management component 100 and the sample adding component 1400. Therefore, the second driving mechanism can drive the sample suction needle to absorb the sample from the sample management component 200 and discharge it into the reaction cup carried by the sample adding component 1400, and the second driving mechanism can drive the sample suction needle to absorb the reagent from the reagent management component 100 and discharge it into the reaction cup carried by the sample adding component 1400. Furthermore, the embodiment of the present application can complete the filling of samples and reagents by a dispensing component 1500, thereby making the volume of the sample analyzer smaller, and also making full use of the narrow gap between the reagent management component 100 and the sample management component 200 to complete the installation of the dispensing component 1500 and the sample adding component 1400.
[0153] Specifically, the second driving mechanism can be used to drive the sample aspirating needle to rotate and rise and fall. The sample management component 200, the reagent management component 100 and the sample adding component 1400 are all located on the rotation path of the sample aspirating needle.
[0154] Alternatively, the second driving mechanism may be a three-dimensional motion mechanism composed of a plurality of linear modules, so as to drive the sample aspirating needle to move between the sample management component 200, the reagent management component 100 and the sample adding component 1400, which is not limited in the embodiment of the present application.
[0155] In some embodiments, the sample analyzer may further include a cleaning component 1600. The cleaning component 1600 is located on the moving path of the sample aspirating needle to clean the sample aspirating needle.
[0156] Specifically, the number of cleaning components 1600 may be one or more, and the embodiment of the present application does not limit this. For example, the cleaning component 1600 may be provided only between the sample adding component 1400 and the reagent management component 100, or only between the sample management component 200 and the reagent management component 100, or both between the sample adding component 1400 and the reagent management component 100 and between the sample management component 200 and the reagent management component 100, and the embodiment of the present application does not limit this.
[0157] Continuing with the above-mentioned sample analyzer, a magnetic separation component 900 may be included. The magnetic separation component 900 may be partially sandwiched between the sample loading component 1400 and the sample management component 200. Further, the space between the sample loading component 1400 and the sample management component 200 is fully utilized to make the structure of the sample analyzer more compact.
[0158] In some embodiments, the sample analyzer described above may include a mixing component 800. The mixing component 800 may be sandwiched between the incubation component 300 and the magnetic separation component 900. Also, the sample adding component 1400 is partially located in the space formed by the magnetic separation component 900, the mixing component 800, and the incubation component 300. Further, the space between the sample adding component 1400 and the sample management component 200 is fully utilized to make the structure of the sample analyzer more compact.
[0159] Specifically, the sample loading component 1400 may include a third rotating disk, and the third rotating disk drives the reaction cup to rotate. Alternatively, the sample loading component 1400 may also include a linear module to drive the reaction cup to perform linear motion.
[0160] In some embodiments, the scheduling structure may include a third driving mechanism and a grabbing mechanism. The third driving mechanism is at least partially adjacent to the side of the incubation part 300 away from the reagent management part 100, or the driving component 1222 is at least partially located at the rear side of the incubation part 300. The grabbing mechanism is used to grab the reaction cup, and the grabbing mechanism is connected to the third driving mechanism in a transmission manner so that the third driving mechanism can drive the grabbing mechanism to move between the reaction cup supply part 700, such as the second turntable 74 of the reaction cup supply part 700, the sample adding part 1400, the incubation part 300, the mixing part 800, the magnetic separation part 900 and the cup throwing position.
[0161] At this time, since the second turntable 74, the sample loading component 1400, the incubation component 300, the mixing component 800, the magnetic separation component 900 and the cup throwing position are all concentrated on the rear side of the reagent management component 100, the third driving mechanism only needs to drive the grasping mechanism to move a very small stroke, so that the third driving mechanism or the scheduling component 500 can be made very small, thereby making the overall volume of the sample analyzer smaller.
[0162] In some embodiments, the sample analyzer may further include a controller, and the controller is used to control the operation and timing of various components of the sample analyzer.
[0163] Next, the first process of controlling the sample analyzer to automatically measure the sample by the controller is taken as an example to further explain the technical solution of the embodiment of the present application. The controller can be configured as follows:
[0164] Control the scheduling component 500 to grab a reaction cup to the sample adding component 1400, and control the sample adding component 1400 to transfer the reaction cup to the sample adding position;
[0165] Control the dispensing component 1500 to inject reagents such as magnetic bead reagents and samples into the reaction cups located at the sample adding positions to mix and form reaction solutions;
[0166] The control dispatching component 500 dispatches the reaction cup carrying the reaction liquid in the sample adding position to the mixing component 800, and controls the mixing component 800 to mix the reaction liquid in the reaction cup;
[0167] The control scheduling component 500 grabs the mixed cuvette in the mixing component 800 into the incubation component 300, and controls the incubation component 300 to incubate the cuvette carrying the mixed reaction solution;
[0168] The control scheduling component 500 grabs the reaction cup that has been incubated once in the intermediate incubation component 300 into the magnetic separation component 900, controls the magnetic separation component 900 to perform magnetic separation and cleaning on the reaction liquid in the reaction cup that has been incubated once to separate impurities in the reaction liquid, and controls the magnetic separation component 900 to inject the substrate into the reaction cup that has been magnetically separated and cleaned to perform luminescent marking;
[0169] The control scheduling component 500 grabs the reaction cup injected with the substrate in the magnetic separation component 900 into the incubation component 300, and controls the incubation component 300 to perform secondary incubation on the reaction cup injected with the substrate;
[0170] The control scheduling component 500 grabs the reaction cup that has been incubated twice in the incubation component 300 to the measurement position, and controls the measurement component 400 to perform a chemiimmunoluminescence test on the reaction solution in the reaction cup at the measurement position;
[0171] The control scheduling component 500 schedules the tested cuvette to the cup throwing position, controls the waste liquid suction component 1300 to suck the waste liquid in the cuvette, and controls the cuvette supporting mechanism 1220 to release the cuvette at the cup throwing position so that the cuvette at the cup throwing position falls into the cuvette container 1210 .
[0172] In the process of controlling the dispensing component 1500 to inject reagents such as magnetic bead reagents and samples into reaction cups located at the sample loading position to mix and form a reaction liquid, the controller can also be configured to: control the dispensing component 1500 to move to the cleaning component 1600 for cleaning after each sample or reagent is absorbed.
[0173] In some embodiments, the controller may also be used to control the sample analyzer to dilute the sample and then prepare the reaction solution; for example, the controller may be configured as follows:
[0174] The dispensing component 1500 is controlled to absorb the sample from the sample management component 200 and discharge it into the first reaction cup located in the sample adding component 1400. The dispensing component 1500 is controlled to absorb the first reagent from the reagent management component 100 and discharge it into the first reaction cup located in the sample adding component 1400. The first reagent is a diluent, so that the sample is diluted to form a first intermediate reaction liquid.
[0175] Controlling the dispensing component 1500 to absorb at least a portion of the first intermediate reaction liquid from the first reaction cup;
[0176] Control the dispensing component 1500 to discharge the sucked first intermediate reaction liquid into the second reaction cup located in the sample adding component 1400;
[0177] The control dispensing part 1500 sucks the second reagent from the reagent management part 100 and discharges it into the second reaction cup so that the second reagent is mixed with the first intermediate reaction liquid to form a second intermediate reaction liquid. The second reagent is different from the first reagent.
[0178] Furthermore, through the cooperation of the dispensing component 1500 and the sample adding component 1400, the sample can be diluted to a specific concentration before being mixed with other reagents such as magnetic bead reagents, thereby improving the accuracy of the reaction solution measured by the measuring component 400. In addition, since the dispensing component 1500, the sample adding component 1400 and the scheduling component 500 are reused for sample dilution, the sample analyzer does not need to set up an additional dilution station and a corresponding dilution component, so the overall structure of the sample analyzer can be made more compact and smaller in size.
[0179] Continuing with the example of the controller being used to control the sample analyzer to dilute the sample for measurement, the controller is configured as follows:
[0180] The control scheduling component 500 schedules the first reaction cup from the reaction cup supply component 700 to the sample adding component 1400;
[0181] Controlling the sample loading component 1400 to move the first reaction cup to the sample loading position;
[0182] The dispensing component 1500 is controlled to absorb the sample from the sample management component 200 and discharge it into the first reaction cup located at the sample loading position. The dispensing component 1500 is controlled to absorb the first reagent from the reagent management component 100 and discharge it into the first reaction cup located at the sample loading component 1400. The first reagent is a diluent, so that the sample is diluted to form a first intermediate reaction liquid.
[0183] Controlling the dispensing component 1500 to absorb at least a portion of the first intermediate reaction liquid from the first reaction cup;
[0184] The control scheduling component 500 schedules the second reaction cup from the reaction cup supply component 700 to the sample adding component 1400;
[0185] Control the sample adding component 1400 to move the second reaction cup to the sample adding position, and control the scheduling component 500 to schedule the first reaction cup to the cup throwing position for recycling;
[0186] Control the dispensing component 1500 to discharge the sucked first intermediate reaction liquid into the second reaction cup located in the sample adding component 1400;
[0187] Controlling the dispensing component 1500 to absorb the second reagent from the reagent management component 100 and discharge it into the second reaction cup, so that the second reagent is mixed with the first intermediate reaction liquid to form a second intermediate reaction liquid, and the second reagent is different from the first reagent;
[0188] The control scheduling component 500 schedules the reaction cup carrying the second intermediate reaction liquid in the sample adding position to the mixing component 800, and controls the mixing component 800 to mix the second intermediate reaction liquid in the reaction cup to obtain a third intermediate reaction liquid;
[0189] The control scheduling component 500 grabs the reaction cup in the mixing component 800 into the incubation component 300, and controls the incubation component 300 to incubate the reaction cup carrying the third intermediate reaction liquid once to obtain a fourth intermediate reaction liquid;
[0190] The control scheduling component 500 grabs the reaction cup carrying the fourth intermediate reaction liquid in the intermediate incubation component 300 into the magnetic separation component 900, controls the magnetic separation component 900 to perform magnetic separation and cleaning on the fourth intermediate reaction liquid carried by the reaction cup to obtain the fifth intermediate reactant, thereby separating impurities in the reaction liquid, and controls the magnetic separation component 900 to inject the substrate into the reaction cup after magnetic separation and cleaning to obtain the sixth intermediate reaction liquid, thereby performing luminescent marking;
[0191] The control scheduling component 500 grabs the reaction cup injected with the substrate in the magnetic separation component 900 into the incubation component 300, and controls the incubation component 300 to perform secondary incubation on the reaction cup carrying the sixth intermediate reaction liquid to obtain the target reaction liquid;
[0192] The control scheduling component 500 grabs the cuvette carrying the target reaction solution in the incubation component 300 to the measurement position, and controls the measurement component 400 to perform a chemiimmunoluminescence test on the target reaction solution in the cuvette at the measurement position;
[0193] The control scheduling component 500 schedules the tested cuvette to the cup throwing position, controls the waste liquid suction component 1300 to suck the waste liquid in the cuvette, and controls the cuvette supporting mechanism 1220 to release the cuvette at the cup throwing position so that the cuvette at the cup throwing position falls into the cuvette container 1210 .
[0194] In the process of controlling the dispensing component 1500 to inject reagents such as magnetic bead reagents and samples into reaction cups located at the sample loading position to mix and form a reaction liquid, the controller can also be configured to: control the dispensing component 1500 to move to the cleaning component 1600 for cleaning after each sample or reagent is absorbed.
[0195] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.
[0196] The sample analyzer provided in the embodiment of the present application is introduced in detail above. Specific examples are used in this article to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only used to help understand the method and core idea of the present application. At the same time, for technical personnel in this field, according to the idea of the present application, there will be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as a limitation on the present application.
Claims
1. A sample analyzer, characterized in that: include: Reagent management component, used for carrying reagents; A sample management component, used for carrying samples; An incubation component, used for incubating the reaction solution in the reaction cup, wherein the reaction solution is prepared from at least the reagent and the sample; A measuring component, used for measuring the reaction solution after incubation; A scheduling component, used for scheduling the reaction cup; and A temperature control component is used to control the temperature of the reagent management component, and the temperature control component includes a first air duct connected to the reagent management component, the first air duct is located on a first side of the reagent management component along a first direction, and the sample management component is located on a second side of the reagent management component along the first direction, and the first side and the second side are opposite.
2. The sample analyzer according to claim 1, characterized in that: The sample analyzer further includes a reaction liquid processing component and a reaction cup supply component, the reaction liquid processing component includes at least one of a mixing component, a magnetic separation component and the incubation component, the mixing component is used to mix the reaction liquid in the reaction cup, the magnetic separation component is used to perform magnetic separation and cleaning on the reaction liquid in the reaction cup and inject substrate, and the reaction cup supply component is used to supply the reaction cup; Wherein, at least one of the reaction liquid processing component, the reaction cup supply component, the measuring component and the scheduling component is located on a third side of the reagent management component along a second direction, and the second direction is perpendicular to the first direction; The sample management component includes a first end, the first end is oriented in the same direction as the fourth side of the reagent management component, the third side is opposite to the fourth side, and the first end is provided with a sample inlet for adding a sample into the sample management component.
3. The sample analyzer according to claim 1, characterized in that: The sample analyzer further includes a cuvette supply component, which is used to supply cuvettes. The cuvette supply component includes a hopper, which is used to hold cuvettes. The hopper is at least partially located on the upper side of the first air duct.
4. The sample analyzer according to claim 1, characterized in that: The sample analyzer also includes a reaction cup supply component, which is used to supply reaction cups, and the orthographic projection of the reaction cup supply component along the first direction partially overlaps with the orthographic projection of the reagent management component along the first direction; the orthographic projection of the reaction cup supply component along the second direction partially overlaps with the orthographic projection of the reagent management component along the second direction, and the first direction and the second direction are perpendicular to each other.
5. The sample analyzer according to claim 1, characterized in that: The incubation component is provided with a plurality of incubation holes, and the incubation holes are used to accommodate reaction cups so as to incubate the reaction liquid in the reaction cups. The plurality of incubation holes are arranged in a honeycomb shape.
6. The sample analyzer according to claim 1, characterized in that: The incubation component is provided with a measurement hole, and the measurement hole is used to accommodate a reaction cup; The measuring component is used to measure the reaction solution after incubation carried by the cuvette in the measuring hole.
7. The sample analyzer according to claim 1, characterized in that: A first escape space is provided on a side of the incubation component facing the reagent management component, and a side of the measurement component facing away from the reagent management component is provided in the first escape space.
8. The sample analyzer according to claim 1, characterized in that: The scheduling component is also used to schedule the reaction cup that has completed the measurement to the cup throwing position, and the sample analyzer also includes: A reaction cup recovery component, comprising a reaction cup container and a reaction cup carrying mechanism, wherein the reaction cup container is used to receive the reaction cup dropped from the cup throwing position, and the reaction cup carrying mechanism is arranged at the cup throwing position to fix or release the reaction cup at the cup throwing position; and The waste liquid suction component is used to suck the reaction liquid in the reaction cup located at the cup throwing position.
9. The sample analyzer according to claim 8, characterized in that: A first avoidance space is provided on a side of the incubation component facing the reagent management component, and the reaction cup recovery component is at least partially disposed in the first avoidance space.
10. The sample analyzer according to claim 8, characterized in that: The waste liquid suction unit is at least partially located in a space surrounded by the cuvette supply unit, the measurement unit, and the reagent management unit.
11. The sample analyzer according to claim 8, characterized in that: The measuring component is used to measure the target reaction liquid carried by the reaction cup located at the measuring position, and the waste liquid suction component includes: A first driving mechanism 1310; a light shield, which is in driving connection with the first driving mechanism, so as to be driven by the first driving mechanism to be away from or cover the reaction cup located at the measuring position; and The waste liquid suction needle is fixedly connected to the light shield, and the waste liquid suction needle can follow the movement of the light shield to approach or move away from the cup throwing position to suck the reaction liquid in the reaction cup located at the cup throwing position.
12. The sample analyzer according to claim 1, characterized in that: The sample analyzer also includes: A sample adding component, disposed on a side of the incubation component facing the sample management component, the sample adding component is used to carry and drive the reaction cup to move; and A dispensing component, used for sucking a target liquid and discharging it into a reaction cup carried by the sample adding component, wherein the target liquid includes at least one of the sample carried by the sample management component and the reagent carried by the reagent management component; The scheduling component is used to schedule the reaction cup between the reaction cup supply component, the incubation component and the sample adding component.
13. The sample analyzer according to claim 12, characterized in that: The sample analyzer further includes a controller, which is configured to: Control the dispensing component to absorb the sample from the sample management component and discharge it into the first reaction cup located in the sample adding component, and control the dispensing component to absorb the first reagent from the reagent management component and discharge it into the first reaction cup located in the sample adding component, wherein the first reagent is a diluent, so that the sample is diluted to form a first intermediate reaction liquid; Controlling the dispensing component to absorb at least a portion of the first intermediate reaction liquid from the first reaction cup; Controlling the dispensing component to discharge the sucked first intermediate reaction liquid into the second reaction cup located in the sample adding component; The dispensing unit is controlled to suck a second reagent from the reagent management unit and discharge the second reagent into the second reaction cup so that the second reagent is mixed with the first intermediate reaction liquid to form a second intermediate reaction liquid, and the second reagent is different from the first reagent.
