Semen ziziphi spinosae nerve soothing and sleep aiding liquid and micro-current application for guiding same into human body

Abstract

The invention discloses a semen ziziphi spinosae nerve soothing and sleep aiding liquid which is introduced into a micro-current application of a human body, and the semen ziziphi spinosae nerve soothing and sleep aiding liquid comprises 5-10 parts of semen ziziphi spinosae, 2-3 parts of poria cocos, 4-8 parts of tea leaf theanine, 3% of water-soluble azone and 2% of borneol. The micro-current application comprises a medical non-woven fabric layer, a printing primary battery layer, a composite microcapsule liquid medicine layer and a medical proof fabric layer which are sequentially connected in the direction facing the skin of the human body, the medical proof fabric layer is used for being pasted on the skin, and the composite microcapsule liquid medicine layer contains semen ziziphi spinosae nerve soothing and sleep aiding liquid. The invention solves the problems that the traditional semen ziziphi spinosae nerve-calming sleep-aiding liquid is sweet and bitter when being orally taken and decocted, is unwilling to take, takes effect slowly, is uncomfortable in digestive system and is large in dosage. The nerve-soothing and sleep-aiding liquid and the micro-current application prepared by adopting the iontophoresis technology are used together, so that the micro-current application has the advantages that the effect is quick, the micro-current application can permeate into a human body through the skin to bypass the digestive tract and the metabolic process, the stimulation and burden on the gastrointestinal tract are reduced, and the convenience and flexibility are realized.

Description

Technical Field

[0001] The invention relates to a sour jujube seed tranquilizing and sleeping-aiding liquid and a micro-current patch for introducing the sour jujube seed into a human body. Background Art

[0002] Tranquilizers are commonly used medical drugs. Their main effects are to calm nerves, help sleep and relieve anxiety. Their active ingredients inhibit the excitability of the central nervous system and regulate the release of neurotransmitters, thereby achieving sedative and anti-anxiety effects. There are many types of sedatives, such as triazolam, diazepam, zolpidem, zopiclone, etc.

[0003] Ziziphus jujuba seed is a common Chinese medicinal material, and its application in traditional medicine has a long history. Ziziphus jujuba seed contains a variety of active ingredients, which can regulate the nervous system, inhibit the central nervous system, protect the cardiovascular system, enhance the body's resistance, and have certain therapeutic and preventive effects on neuropsychiatric diseases, cardiovascular diseases, endocrine diseases, etc. Modern medical data show that Ziziphus jujuba seed can nourish the heart and calm the mind, astringe sweat and produce body fluid, nourish yin and replenish deficiency, and treat insomnia, palpitations, dreaminess, night sweats, thirst, etc.

[0004] There is no micro-current application type tranquilizing and sleeping aid medicine with Chinese jujube seeds as the main ingredient on the market. Moreover, the existing tranquilizing and sleeping aid medicines are mostly Western medicines and most of them are taken orally. In this regard, the present invention proposes a Chinese jujube tranquilizing and sleeping aid liquid for micro-current application and a preparation method thereof. Summary of the invention

[0005] The invention provides a Chinese jujube seed tranquilizing and sleeping-aiding liquid and a microcurrent patch for introducing the liquid into human body, which solves the problems of traditional Chinese jujube seed tranquilizing and sleeping-aiding liquid being taken orally, being unwilling to take it when decocted, taking effect slowly, causing discomfort to the digestive system and requiring a large dosage.

[0006] In a first aspect, a soothing and sleeping-aiding solution of Chinese jujube seeds is provided, comprising: 5-10 parts of Chinese jujube seeds, 2-3 parts of Poria cocos, 4-8 parts of tea theanine, 3% water-soluble azone and 2% borneol.

[0007] Secondly, a microcurrent patch is proposed, which includes a medical non-woven fabric layer, a printed primary battery layer, a composite microcapsule drug solution layer and a medical tape layer for sticking on the skin, which are connected in sequence along the direction toward the human skin. The composite microcapsule drug solution layer contains the Chinese jujube seed soothing and sleeping-aiding solution. After the composite microcapsule drug solution layer is destroyed, the Chinese jujube seed soothing and sleeping-aiding solution therein flows out and infiltrates the printed primary battery layer, so that the printed primary battery layer is turned on and discharged, forming a microcurrent between the skin and the charged Chinese jujube seed soothing and sleeping-aiding solution ions pass through the skin tissue barrier and enter the human body under the action of the microcurrent.

[0008] The present invention penetrates into the human body through the skin, promotes drug absorption through the action of microcurrent, bypasses the digestive tract and metabolic process; the microcurrent application administration method has a relatively short action time and a fast onset; weak current stimulation is generated in the application area, promoting blood circulation and local metabolism, and enhancing drug absorption and efficacy; convenient and flexible: microcurrent patches can be pasted on specific parts of the body, without being restricted by time and space, and can be administered anytime and anywhere. At the same time, application administration does not require complex steps such as decoction and soaking, which is more convenient and quick; reduce side effects: oral administration may cause adverse gastrointestinal reactions, while microcurrent application administration avoids such problems and reduces the stimulation and burden on the gastrointestinal tract. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Figure 1 This is a schematic diagram of the microcurrent application of the Chinese jujube seed tranquilizing and sleeping-aiding liquid. DETAILED DESCRIPTION

[0010] A soothing and sleeping-aiding liquid of Chinese jujube seeds comprises the following components: Chinese jujube seeds, Poria cocos, tea theanine, water-soluble azone and borneol. The contents of each component are as follows by weight: 5-10 parts of Chinese jujube seeds, 2-3 parts of Poria cocos, 4-8 parts of tea theanine, 3% water-soluble azone, and 2% borneol. The content ratio of Chinese jujube seeds extract, tea theanine, Poria cocos extract, azone, and borneol is 4:4:3:2:1.

[0011] The preparation method of the above-mentioned sour jujube seed tranquilizing and sleeping-aiding liquid for micro-current application comprises the following steps:

[0012] S1, preparation of spiny jujube seed extract:

[0013] (1) defatting the raw drug powder of Chinese jujube seeds to obtain defatted Chinese jujube seeds powder, mixing the defatted Chinese jujube seeds powder with cellulase and pectinase, adding water to dissolve, and adjusting the pH value to 4.5 to prepare an enzymatic solution, and performing enzymatic hydrolysis at 40°C for 5 hours, wherein the amount of cellulase used is 30U / g Chinese jujube seeds raw drug, and the amount of pectinase used is 30U / g Chinese jujube seeds raw drug; (2) subjecting the enzymatic hydrolysis solution to reflux water extraction twice, each time for 1 hour, and then filtering to collect the Chinese jujube seeds saponin water extract; (3) subjecting the Chinese jujube seeds saponin water extract to rotary evaporation at 60-65°C to obtain a concentrated product; (4) subjecting the concentrated product to alcohol precipitation with 70% ethanol for 24 hours, and taking the supernatant liquid; rotary evaporating the supernatant at 60-65° C. to obtain a Ziziphus jujuba seed extract, and vacuum drying the Ziziphus jujuba seed extract to obtain a Ziziphus jujuba seed crude extract containing saponins; (5) dissolving the Ziziphus jujuba seed crude extract containing saponins obtained in step (4) in water, filtering, collecting the filtrate to obtain a Ziziphus jujuba seed extract, wherein the mass volume ratio concentration of the Ziziphus jujuba seed extract is 4.5 mg / ml; adsorbing the Ziziphus jujuba seed extract with AB-8 macroporous adsorption resin, first washing with water to remove polysaccharide impurities, and then eluting with 30%-70% ethanol gradient, collecting the eluate, and concentrating it by rotary evaporation at 60-65° C., and then vacuum drying the concentrate to obtain an extract containing ≥40% of total saponins in Ziziphus jujuba seed.

[0014] S2, preparing Poria cocos extract:

[0015] Take 300 g of powder from different parts of Poria cocos after drying, add distilled water at a solid-liquid ratio of 1:20, stir and extract at 65°C for 3 h, repeat twice, combine the filtrate, concentrate under reduced pressure to 100 mL, cool and store in a refrigerator at 4°C for later use.

[0016] S3, prepare tea theanine using the method for preparing the Ziziphus jujuba seed extract.

[0017] The above-mentioned spinulosa jujuba seeds, tea theanine, Poria cocos extract, azone and borneol were dissolved in distilled water at a ratio of 4:4:3:2:1 to prepare a 400.0 μg·mL-1 solution.

[0018] The present invention adopts Figure 1 The micro-current patch shown introduces the sour jujube seed tranquilizing and sleeping aid solution from the skin into the body. The micro-current patch is used to carry the sour jujube seed tranquilizing and sleeping aid solution for skin absorption, and is also the direct working part of the product function and intradermal administration, such as Figure 1 As shown, the microcurrent patch comprises a medical non-woven fabric layer 1, a printed primary battery layer 2, a composite microcapsule drug solution layer 3 and a medical adhesive tape layer 4 which are connected in sequence.

[0019] The medical nonwoven fabric layer 1 is used as a protective layer and is located at the outermost layer.

[0020] Cellulose paper and hydrogel are used as printing substrates for printing the primary battery layer 2, and the electrode materials are zinc negative electrode metal ink and silver positive electrode metal ink. Zinc powder, graphite, and PVDF are mixed with NMP solvent at a weight ratio of 1:0.2:0.05:0.05, and the zinc negative electrode ink is prepared by adjusting the mixer (THINKYMIXER, AR-100). Nano silver oxide, graphite, and PVDF are mixed at a weight ratio of 1:0.2:2 to prepare silver positive electrode metal ink.

[0021] The composite microcapsule liquid layer 3 comprises microcapsules containing the sour jujube seed tranquilizing and sleep-inducing liquid. The sour jujube seed tranquilizing and sleep-inducing liquid is quantitatively injected into the microcapsules in advance during manufacture. The capsule material of the microcapsules is chitosan.

[0022] There is a thin film on the surface of the medical adhesive tape layer 4. After tearing off the thin film, the micro-current patch can be pasted on the skin.

[0023] When in use, tear off the film on the surface of the medical tape layer 4 of the micro-current patch, stick the micro-current patch on the skin, press the patch, destroy the structural integrity of the composite microcapsule 3, and make the Chinese medicine liquid flow out and infiltrate the printed primary battery layer 2. Once the printed primary battery layer 2 contacts the liquid medicine (medium), it conducts and discharges, forming a micro-current between the micro-current skin test patch and the skin. The micro-current is at the milliampere level and will not cause any harm to the human body. After the micro-current is formed, the charged ion drug passes through the tissue barrier such as the skin and enters the human body under the low-intensity DC electric field generated by it.

[0024] The following is a comparison of a group of oral administration of sour jujube seed soothing and sleep-inducing liquid and the use of micro-current application to introduce the sour jujube seed soothing and sleep-inducing liquid into the human body:

[0025] Dosage Digestive and gastrointestinal adverse effects Onset time (h) Efficacy (%) Oral administration Strong 3 50％ Microcurrent patch drug delivery none 1.5 75％

[0026] The present invention uses the tranquilizing and sleeping-aiding liquid together with the microcurrent patch made by ion introduction technology, which has the advantages of rapid onset of action, penetrating into the human body through the skin to bypass the digestive tract and metabolic process, reducing stimulation and burden on the gastrointestinal tract, and being convenient and flexible.

Claims

1. A soothing and sleeping-aiding liquid containing Chinese date seeds, characterized in that: The invention comprises: 5-10 parts of sour jujube seeds, 2-3 parts of tuckahoe, 4-8 parts of tea theanine, 3% of water-soluble azone and 2% of borneol.

2. A microcurrent patch, characterized in that: Along the direction toward human skin, it comprises a medical non-woven fabric layer, a printed primary battery layer, a composite microcapsule drug liquid layer and a medical tape layer for sticking on the skin, which are connected in sequence; the composite microcapsule drug liquid layer contains the Chinese jujube seed calming and sleeping-aiding solution; after the composite microcapsule drug liquid layer is destroyed, the Chinese jujube seed calming and sleeping-aiding solution inside flows out and infiltrates the printed primary battery layer, making the printed primary battery layer conductive and discharged, forming a microcurrent between the printed primary battery layer and the skin; the charged Chinese jujube seed calming and sleeping-aiding solution ions pass through the skin tissue barrier and enter the human body under the action of the microcurrent.

3. The microcurrent patch according to claim 2, characterized in that: The Chinese jujube seed tranquilizing and sleeping aid solution contains 5-10 portions of Chinese jujube seeds.

4. The microcurrent patch according to claim 2, characterized in that: The Chinese Date Seed Calming and Sleep-Aiding Liquid contains 2-3 portions of Poria cocos.

5. The microcurrent patch according to claim 2, characterized in that: The Chinese date seed tranquilizing and sleeping aid solution contains 4-8 portions of tea theanine.

6. The microcurrent patch according to claim 2, characterized in that: The Chinese date seed tranquilizing and sleeping aid solution contains 3% water-soluble azone.

7. The microcurrent patch according to claim 2, characterized in that: The Chinese date seed tranquilizing and sleeping aid solution contains 2% borneol.

8. The microcurrent patch according to claim 2, characterized in that: The printed galvanic layers include zinc negative electrode metal ink and silver positive electrode metal ink.

9. The microcurrent patch according to claim 8, characterized in that: The zinc negative electrode metal ink contains zinc powder, graphite and PVDF.

10. The microcurrent patch according to claim 8, characterized in that: The silver positive electrode metal ink contains nano silver oxide, graphite and PVDF.

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