Spray drying device for preparing iodine contrast agent

Abstract

The invention relates to the technical field of iodine contrast agent preparation, in particular to a spray drying device for iodine contrast agent preparation. According to the technical scheme, the spray dryer comprises a spray dryer body, a storage barrel and a material conveying hard pipe arranged on the spray dryer body, and further comprises a material conveying hose fixedly connected to the bottom end of the material conveying hard pipe; and the support is arranged on the outer wall of the spray dryer. Through the design of structures such as the conveying hose, the support, the clamping cover, the stirring mechanism and the lifting mechanism, before the iodine contrast agent in the storage barrel is conveyed into the spray dryer for preparation and processing, the stirring mechanism can uniformly stir the iodine contrast agent in the storage barrel, so that layering of different components can be avoided, and the uniformity of the iodine contrast agent in the storage barrel is improved; the effective components of the iodine contrast agent are uniformly distributed, and the use effect is improved. Meanwhile, the clamping cover is clamped at the top of the storage barrel to shield the iodine contrast agent, so that pollutants in air above the storage barrel are prevented from entering the storage barrel, and the iodine contrast agent is prevented from being polluted.

Description

Technical Field

[0001] The invention relates to the technical field of iodine contrast agent preparation, in particular to a spray drying device for preparing iodine contrast agent. Background Art

[0002] Iodine contrast agents are iodine-containing contrast agents that are mainly used in medical imaging examinations, such as X-rays, CT scans, and angiography. Powdered contrast agents are usually more convenient to dissolve and prepare in clinical applications, and are more flexible to use. In the preparation process of iodine contrast agents, a spray dryer is usually used to quickly convert liquid raw materials into powdered finished products. In the prior art, a feed hose is provided on the spray dryer for placement in a container containing iodine contrast agents, and the iodine contrast agents are transported to the spray dryer for preparation. However, iodine contrast agents are prone to stratification or precipitation during long-term storage. Later stratification or precipitation will cause uneven composition of the dried product, thereby affecting its effectiveness and consistency. At the same time, when the feed hose is placed in a container containing iodine contrast agents, there is no shielding above the container, which can easily allow pollutants in the air to enter the container, causing the iodine contrast agent to be contaminated. Summary of the invention

[0003] The object of the present invention is to solve the problem that iodine contrast agents in the prior art are prone to stratification or precipitation during long-term storage. The stratification or precipitation will cause uneven composition of the dried product, thereby affecting its effectiveness and consistency. At the same time, when the feed hose is placed in a container containing iodine contrast agents, there is no shielding above the container, resulting in the problem that the iodine contrast agents are contaminated. A spray drying device for preparing iodine contrast agents is provided.

[0004] The technical solution of the present invention is as follows: a spray drying device for preparing iodine contrast agent comprises a spray dryer and a storage barrel and a material delivery hard pipe arranged on the spray dryer, and also comprises: a material delivery hose fixedly connected to the bottom end of the material delivery hard pipe; a support mounted on the outer wall of the spray dryer, the bottom end of the support being provided with a card cover covering the top opening of the storage barrel; a stirring mechanism arranged on the lower surface of the card cover to stir the material in the storage barrel, the stirring mechanism comprising an elliptical sleeve and an elliptical slide bar in sliding connection; a lifting mechanism, mounted at the bottom end of the support to drive the stirring mechanism to move up and down to fully stir the storage barrels at different heights; and a sliding mechanism arranged in the elliptical sleeve and the elliptical slide bar to enable the card cover to tightly clamp the top ends of the storage barrels at different heights.

[0005] Optionally, the stirring mechanism includes a rotating block rotatably connected to the card cover, the lower surface of the rotating block is fixedly connected to the elliptical sleeve, the outer wall of the elliptical slide rod is fixedly connected to a plurality of stirring rods distributed in a circular array, the bottom end of the stirring rod is provided with a plurality of suction holes distributed in a circular array, the cross-sectional shape of the elliptical sleeve and the elliptical slide rod is elliptical, the top end of the rotating block is fixedly connected to a gear sleeve, the upper surface of the gear sleeve is fixedly connected to a sealing block for inserting the bottom end of a feed hose, a sealing groove is provided inside the sealing block, the internal sealing of the sealing groove is provided with a first sealing ring, and one end of the feed hose inserted into the sealing block and the gear sleeve is fixedly connected with a clamping ring that clamps the first sealing ring.

[0006] Optionally, the stirring mechanism also includes a bracket fixedly connected to the upper surface of the card cover, and a motor is fixedly connected to the upper surface of one end of the bracket. The output shaft of the motor is movably passed through the bracket and fixedly connected to a main gear, and the main gear is meshingly connected to the gear sleeve.

[0007] Optionally, the lifting mechanism includes a U-shaped frame fixedly connected to the upper surface of the support, the upper surface of the U-shaped frame is fixedly connected to a cylinder, the cylinder piston rod is movably passed through the U-shaped frame and is fixedly connected to a driving plate, the driving plate is fixedly connected to one end away from the cylinder output shaft with a pair of lugs, the lower surface of the lugs is fixedly connected to a pair of fixing rods, and the bottom ends of the fixing rods are fixedly connected to the upper surface of the support.

[0008] Optionally, the support is provided with a telescopic groove for the driving plate to be inserted into.

[0009] Optionally, one end of the driving plate close to the lug is provided with a through hole for the material delivery hose to pass through.

[0010] Optionally, the sliding mechanism includes a pair of clamping sleeves fixedly connected to the end of the elliptical slide rod inserted into the elliptical sleeve, a mounting groove is opened in the middle of the clamping sleeve, and a second sealing ring is provided inside the mounting groove to tightly connect the elliptical slide rod and the elliptical sleeve.

[0011] Optionally, a clamping ring for clamping the sleeve is fixedly connected to the inner wall of one end of the elliptical sleeve close to the elliptical sliding rod.

[0012] Optionally, a pair of support rods are fixedly connected to the outer wall of the support, and ends of the support rods away from the support are fixedly connected to the outer wall of the spray dryer.

[0013] Optionally, a support block supporting a material conveying hard pipe is fixedly connected to the outer wall of the spray dryer.

[0014] In summary, the present application includes at least one of the following beneficial technical effects:

[0015] The present invention uses the design of the feeding hose, support, card cover, stirring mechanism and lifting mechanism. Before the iodine contrast agent in the storage barrel is fed to the spray dryer for preparation and processing, the stirring mechanism can stir the iodine contrast agent in the storage barrel evenly, which can not only avoid stratification between different components, but also ensure that the effective components of the iodine contrast agent are evenly distributed, thereby improving the use effect. At the same time, the card cover is stuck on the top of the storage barrel to shield the iodine contrast agent, thereby preventing pollutants in the air above the storage barrel from entering and avoiding the iodine contrast agent from being contaminated;

[0016] Furthermore, the present invention utilizes the coordination of structures such as an elliptical sleeve, an elliptical slide rod, and a sliding mechanism, so that multiple stirring rods and suction holes on the elliptical slide rod can be adjusted according to storage barrels of different heights, ensuring that the stirring rod is always in contact with the bottom wall of the storage barrel, thereby improving the stirring and material feeding efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic structural diagram of a spray drying device for preparing an iodine contrast agent according to the present invention is provided;

[0018] Figure 2 for Figure 1 Schematic diagram of some structures;

[0019] Figure 3 for Figure 2 Schematic diagram of the split structure;

[0020] Figure 4 for Figure 3 A schematic diagram of a partial cross-sectional structure;

[0021] Figure 5 for Figure 2 Schematic diagram of some structures;

[0022] Figure 6 for Figure 5 Schematic diagram of some structures;

[0023] Figure 7 for Figure 6 A schematic cross-sectional structure diagram of ;

[0024] Figure 8 for Figure 7 Schematic diagram of the partial split structure.

[0025] Figure numerals: 1, spray dryer; 11, feed pipe; 2, support block; 3, feed hose; 31, sealing block; 311, sealing slide; 312, first sealing ring; 32, gear sleeve; 33, rotating block; 34, snap ring; 4, support; 41, support rod; 42, telescopic slot; 5, card cover; 51, bracket; 52, motor; 53, main gear; 6, U-shaped frame; 61, cylinder; 62, driving plate; 63, lug; 64, fixing rod; 65, perforation; 7, elliptical sleeve; 71, snap ring; 8, elliptical slide; 81, card sleeve; 82, installation groove; 83, stirring rod; 84, suction hole; 85, second sealing ring; 9, storage barrel. DETAILED DESCRIPTION

[0026] The technical solution of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments.

[0027] The components of the embodiments of the present invention generally described and shown in the drawings herein may be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present invention provided in the drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the present invention.

[0028] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative work shall fall within the scope of protection of the present invention.

[0029] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0030] It should be noted that the terms "include", "comprises" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0031] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0032] Example

[0033] like Figures 1 to 8 As shown, a spray drying device for preparing an iodine contrast agent proposed by the present invention comprises a spray dryer 1, a storage barrel 9 and a feed tube 11 arranged on the spray dryer 1. The spray dryer 1 is a device for converting liquid materials into dry powders, which is widely used in food, chemical, pharmaceutical and other industries. Its main working principle is to atomize the liquid material into tiny droplets through a spray device, and then quickly evaporate the water in hot air to form a dry powder. The material of the feed tube 11 is hard plastic. The outer wall of the spray dryer 1 is fixedly connected with a support block 2 supporting the feed tube 11, and also includes: a feed hose 3, and the material of the feed hose 3 is a soft rubber tube. The bottom end of the feeding hard pipe 11 is fixedly connected; the support 4 installed on the outer wall of the spray dryer 1, the outer wall of the support 4 is fixedly connected with a pair of support rods 41, and the end of the support rod 41 away from the support 4 is fixedly connected to the outer wall of the spray dryer 1, and the bottom end of the support 4 is provided with a card cover 5 covering the top opening of the storage bucket 9. When the card cover 5 moves downward to clamp the storage bucket 9, the center of the storage bucket 9 and the center of the card cover 5 will overlap correspondingly up and down, thereby playing a corrective role; the stirring mechanism is arranged on the lower surface of the card cover 5 to stir the material in the storage bucket 9, and the stirring mechanism stirs the iodine contrast agent in the storage bucket 9 evenly, which helps to ensure the consistency and stability of the final product and reduce the risk of adverse reactions and side effects. At the same time, the iodine contrast agent can be kept in a uniform state before entering the spray drying chamber, thereby improving the drying efficiency and the drying uniformity of the product. In addition, it also helps to prevent the material from gathering or depositing in the storage bucket 9, reduce the risk of equipment clogging, and keep the production line smooth. The stirring mechanism includes an elliptical sleeve 7 and an elliptical slide rod 8 which are slidably connected. The cross-sections of the elliptical sleeve 7 and the elliptical slide rod 8 are elliptical, and their function is that the rotation of the elliptical sleeve 7 will drive the elliptical slide rod 8 to rotate; a lifting mechanism, which is installed at the bottom end of the support 4 to drive the stirring mechanism to move up and down to fully stir the storage buckets 9 at different heights; a sliding mechanism which is arranged in the elliptical sleeve 7 and the elliptical slide rod 8 so that the card cover 5 can tightly clamp the top of the storage buckets 9 at different heights.

[0034] Further, the stirring mechanism includes a rotating block 33 rotatably connected to the card cover 5, the lower surface of the rotating block 33 is fixedly connected to the elliptical sleeve 7, the outer wall of the elliptical slide bar 8 is fixedly connected with a plurality of stirring rods 83 distributed in a circumferential array, the bottom end of the stirring rod 83 is provided with a plurality of suction holes 84 distributed in a circumferential array, and the suction holes 84 are connected to the elliptical sleeve 7 and the elliptical slide bar 8. The cross-sectional shape of the elliptical sleeve 7 and the elliptical slide bar 8 is elliptical, the top of the rotating block 33 is fixedly connected with a gear sleeve 32, the upper surface of the gear sleeve 32 is fixedly connected with a sealing block 31 for inserting the bottom end of the feeding hose 3, the sealing block 31 is provided with a sealing groove 311 inside, and the sealing groove 311 is sealed with a first sealing ring 312 inside, and the first sealing ring 312 is used to achieve a sealed connection between the end of the feeding hose 3 and the inner wall of the sealing block 31. One end of the feed hose 3 inserted into the sealing block 31 and the gear sleeve 32 is fixedly connected with a clamping ring 34 that clamps the first sealing ring 312. The clamping ring 34 clamps the first sealing ring 312 to prevent the end of the feed hose 3 from escaping from the sealing block 31, thereby playing a clamping role.

[0035] The stirring mechanism further includes a bracket 51 fixedly connected to the upper surface of the card cover 5, and a motor 52 is fixedly connected to the upper surface of one end of the bracket 51. The output shaft of the motor 52 movably passes through the bracket 51 and is fixedly connected to a main gear 53, which is meshed with the gear sleeve 32.

[0036] Secondly, the lifting mechanism includes a U-shaped frame 6 fixedly connected to the upper surface of the support 4, a cylinder 61 is fixedly connected to the upper surface of the U-shaped frame 6, and a driving plate 62 is fixedly connected after the piston rod of the cylinder 61 moves through the U-shaped frame 6. The support 4 is provided with a telescopic groove 42 for the driving plate 62 to be inserted into, and a through hole 65 is provided at one end of the driving plate 62 close to the lug 63 for the material delivery hose 3 to pass through, and the through hole 65 is so that the driving plate 62 will not be stuck by the material delivery hose 3 when moving up and down. A pair of lugs 63 are fixedly connected to one end of the driving plate 62 away from the output shaft of the cylinder 61, and a pair of fixed rods 64 are fixedly connected to the lower surface of the lug 63, and the bottom ends of the fixed rods 64 are fixedly connected to the upper surface of the support 4.

[0037] Further, the sliding mechanism includes a pair of ferrules 81 fixedly connected to the end of the elliptical slide bar 8 inserted into the elliptical sleeve 7, and the ferrule 81 is elliptical in shape. The inner wall of one end of the elliptical sleeve 7 close to the elliptical slide bar 8 is fixedly connected with a ferrule 71 for clamping the ferrule 81, and the ferrule 71 is to prevent the elliptical slide bar 8 from coming out of the end of the elliptical sleeve 7. A mounting groove 82 is provided in the middle of the ferrule 81, and a second sealing ring 85 is provided inside the mounting groove 82 so that the elliptical slide bar 8 and the elliptical sleeve 7 are closely connected. The first sealing ring 312 and the second sealing ring 85 are sealing rings, which are a mechanical component for preventing liquid, gas or powder from leaking, and are usually made of elastic materials (such as rubber, plastic or silicone). The second sealing ring 85 is to make the end of the elliptical slide bar with the ferrule 81 slide in the elliptical sleeve 7 and be sealed and connected, and its principle is the same as the plug in the needle tube.

[0038] In this embodiment, when the iodine contrast agent preparation requires the use of a spray drying device, such as Figure 1As shown, the storage bucket 9 containing iodine contrast agent is placed just below the card cover 5. Afterwards, the cylinder 61 on the U-shaped frame 6 is started, and the piston rod of the U-shaped frame 6 drives the driving plate 62 to move, and the driving plate 62 drives the lug 63 to move away from one end of the piston rod of the cylinder 61, and the lug 63 drives the fixed rod 64 to move, and multiple fixed rods 64 drive the card cover 5 to move downward. The card cover 5 drives the sealing block 31, the gear sleeve 32, the rotating block 33, the elliptical sleeve 7 and the elliptical slide bar 8 to move downward in sequence, so that the stirring rod 83 at the bottom of the elliptical slide bar 8 is inserted into the storage bucket 9 and contacts with the iodine contrast agent. Then the card cover 5 is moved downward again, until the bottom end of the suction hole 84 is against the inner bottom wall of the storage bucket 9, and the top of the elliptical slide bar 8 is slowly inserted into the elliptical sleeve 7, and the second sealing ring 85 that is stuck by the mounting groove 82 at the top of the elliptical slide bar 8 makes the elliptical slide bar 8 produce a sealing effect when moving in the elliptical sleeve 7. When the bottom of the card cover 5 completely covers the top of the storage bucket 9, the card cover 5 can block the top of the storage bucket 9. Then the motor 52 on the bracket 51 can be started, and the output shaft of the motor 52 drives the main gear 53 to rotate. Since the main gear 53 is meshed with the gear sleeve 32, the main gear 53 drives the gear sleeve 32 to rotate, and the gear sleeve 32 drives the rotating block 33 to clamp the card cover 5 to rotate. The rotating block 33 drives the elliptical sleeve 7 and the elliptical slide bar 8 to rotate in turn, and the elliptical slide bar 8 drives the multiple stirring rods 83 thereon to stir the iodine contrast agent in the storage bucket 9 to avoid stratification or precipitation of the iodine contrast agent in the storage bucket 9. The clamping ring 34 of the feeding hose 3 in the sealing block 31 is clamped by the first sealing ring 312 in the sealing chute 311, thereby avoiding air leakage between the feeding hose 3 and the sealing block 31. Finally, by starting the spray dryer 1, the feed tube 11 can generate suction, and the feed tube 11 generates suction through the feed hose 3, the sealing block 31, the gear sleeve 32, the rotating block 33, the elliptical sleeve 7 and the elliptical slide bar 8 in sequence, and then the iodine contrast agent in the storage barrel 9 is absorbed through the multiple suction holes 84 at the bottom end of the elliptical slide bar 8 and transported to the spray dryer 1 for preparation and processing.

[0039] The preferred embodiments of the present invention described above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to only specific implementation methods. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A spray drying device for preparing iodine contrast agent, comprising a spray dryer (1), a storage bucket (9) and a material delivery hard pipe (11) arranged on the spray dryer (1), characterized in that: Also includes: A material delivery hose (3) fixedly connected to the bottom end of the material delivery hard pipe (11); A support (4) mounted on the outer wall of the spray dryer (1), wherein the bottom end of the support (4) is provided with a card cover (5) covering the top opening of the storage barrel (9); A stirring mechanism, arranged on the lower surface of the card cover (5) to stir the material in the storage bucket (9), the stirring mechanism comprising an elliptical sleeve (7) and an elliptical sliding rod (8) which are slidably connected; A lifting mechanism, installed at the bottom end of the support (4), drives the stirring mechanism to move up and down to fully stir the storage barrels (9) at different heights; A sliding mechanism is arranged in the elliptical sleeve (7) and the elliptical slide rod (8) so that the card cover (5) can tightly clamp the top of the storage bucket (9) of different heights.

2. The spray drying device for preparing an iodine contrast agent according to claim 1, characterized in that: The stirring mechanism comprises a rotating block (33) rotatably connected to the card cover (5), the lower surface of the rotating block (33) is fixedly connected to the elliptical sleeve (7), the outer wall of the elliptical slide rod (8) is fixedly connected to a plurality of stirring rods (83) distributed in a circular array, the bottom end of the stirring rod (83) is provided with a plurality of suction holes (84) distributed in a circular array, the cross-section shape of the elliptical sleeve (7) and the elliptical slide rod (8) is elliptical, and the top end of the rotating block (33) is fixedly connected to the outer wall of the elliptical slide rod (8). A gear sleeve (32) is fixedly connected thereto; a sealing block (31) for inserting the bottom end of the material delivery hose (3) is fixedly connected to the upper surface of the gear sleeve (32); a sealing groove (311) is provided inside the sealing block (311); a first sealing ring (312) is provided inside the sealing groove (311); and a clamping ring (34) for clamping the first sealing ring (312) is fixedly connected to one end of the material delivery hose (3) inserted into the sealing block (31) and the gear sleeve (32).

3. The spray drying device for preparing an iodine contrast agent according to claim 1, characterized in that: The stirring mechanism further comprises a bracket (51) fixedly connected to the upper surface of the card cover (5); a motor (52) is fixedly connected to the upper surface of one end of the bracket (51); an output shaft of the motor (52) movably passes through the bracket (51) and is fixedly connected to a main gear (53); the main gear (53) is meshedly connected to the gear sleeve (32).

4. The spray drying device for preparing an iodine contrast agent according to claim 1, characterized in that: The lifting mechanism comprises a U-shaped frame (6) fixedly connected to the upper surface of the support (4); the upper surface of the U-shaped frame (6) is fixedly connected to a cylinder (61); the piston rod of the cylinder (61) movably passes through the U-shaped frame (6) and is fixedly connected to a driving plate (62); one end of the driving plate (62) away from the output shaft of the cylinder (61) is fixedly connected to a pair of lugs (63); the lower surface of the lugs (63) is fixedly connected to a pair of fixing rods (64); the bottom ends of the fixing rods (64) are fixedly connected to the upper surface of the support (4).

5. The spray drying device for preparing an iodine contrast agent according to claim 4, characterized in that: The support (4) is provided with a telescopic groove (42) for the driving plate (62) to be inserted into.

6. A spray drying device for preparing an iodine contrast agent according to claim 4, characterized in that: One end of the driving plate (62) close to the lug (63) is provided with a through hole (65) for the material delivery hose (3) to pass through.

7. A spray drying device for preparing an iodine contrast agent according to claim 1, characterized in that: The sliding mechanism comprises a pair of clamping sleeves (81) fixedly connected to the end of the elliptical sliding rod (8) inserted into the elliptical sleeve (7), a mounting groove (82) is provided in the middle of the clamping sleeve (81), and a second sealing ring (85) is provided inside the mounting groove (82) so that the elliptical sliding rod (8) and the elliptical sleeve (7) are tightly connected.

8. A spray drying device for preparing an iodine contrast agent according to claim 7, characterized in that: A clamping ring (71) for clamping a clamping sleeve (81) is fixedly connected to the inner wall of one end of the elliptical sleeve (7) close to the elliptical slide rod (8).

9. The spray drying device for preparing an iodine contrast agent according to claim 1, characterized in that: A pair of support rods (41) are fixedly connected to the outer wall of the support (4), and ends of the support rods (41) away from the support (4) are fixedly connected to the outer wall of the spray dryer (1).

10. The spray drying device for preparing an iodine contrast agent according to claim 1, characterized in that: A support block (2) for supporting a material conveying hard pipe (11) is fixedly connected to the outer wall of the spray dryer (1).

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