Preparation method of high-oxygen-permeability silica hydrogel and high-oxygen-permeability silica hydrogel corneal contact lens

Abstract

The invention belongs to the technical field of silicon hydrogel, and discloses high-oxygen-permeability silicon hydrogel and a preparation method of a high-oxygen-permeability silicon hydrogel corneal contact lens. The high-oxygen-permeability silicon hydrogel is prepared from the following raw materials in parts by mass: 10 to 50 parts of hydroxyl-terminated polydimethylsiloxane, 10 to 50 parts of small molecular silicon monomer, 20 to 70 parts of hydrophilic monomer, 0.1 to 10 parts of initiator, 0.1 to 10 parts of cross-linking agent and 30 to 60 parts of solvent. According to the preparation method disclosed by the invention, the compatibility of the hydroxyl-terminated polydimethylsiloxane and the hydrophilic monomer can be improved by introducing the small molecular silicon monomer, and meanwhile, the oxygen permeability of the high-oxygen-permeability silicon hydrogel is also favorably improved; hydroxyl in the hydroxyl-terminated polydimethylsiloxane is selected as a hydrophilic group, so that the hydroxyl-terminated polydimethylsiloxane has good hydrophilic performance, and the compatibility of the polydimethylsiloxane and a hydrophilic monomer is improved; the hydrophilic performance of the high-oxygen-permeability silica hydrogel is improved, and meanwhile the oxygen permeability can be improved.

Description

Technical Field

[0001] The present invention relates to the technical field of silicone hydrogels, and in particular to a highly oxygen permeable silicone hydrogel and a method for preparing a highly oxygen permeable silicone hydrogel corneal contact lens. Background Art

[0002] Corneal contact lenses, also known as "contact lenses", are more and more popular with people than ordinary frame glasses because of their high water content, softness, comfort and convenience. The number of people using them is increasing significantly. Hydrogel corneal contact lenses have low oxygen permeability, and high water content lenses are more comfortable to wear. However, in northern regions with low humidity, the water in the corneal contact lenses is easy to evaporate during long-term wear, so that the corneal contact lenses will absorb tears from the human eye to maintain the original water content, which can easily cause symptoms such as corneal hypoxic edema, eye inflammation, conjunctival congestion, dry eyes and neovascularization.

[0003] Due to the shortcomings of hydrogel materials, efforts are currently being made to find more preferred lens materials. Silicone hydrogel combines the advantages of high oxygen permeability of silicone rubber materials and strong hydrophilicity of hydrogel materials, and is currently the most promising soft contact lens material. Silicone hydrogel materials, such as those used in contact lenses, need to introduce siloxane components into the material in order to increase the oxygen permeability of the material. Materials containing siloxane molecular structures have strong hydrophobicity and feel dry when worn, affecting the wearing comfort. Therefore, the problems that silicone hydrogel materials currently need to solve include: maintaining the long-lasting wettability or lubricity of contact lenses to improve wearing comfort; increasing the oxygen permeability of lenses to enhance wearing safety. Summary of the invention

[0004] The purpose of the present invention is to provide a high oxygen permeability silicone hydrogel and a method for preparing a high oxygen permeability silicone hydrogel corneal contact lens, so as to solve the technical problem of poor oxygen permeability of existing silicone hydrogels.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The present invention provides a high oxygen permeability silicone hydrogel, comprising the following raw materials in parts by weight:

[0007] 10 to 50 parts of hydroxyl-terminated polydimethylsiloxane, 10 to 50 parts of small molecule silicon monomer, 20 to 70 parts of hydrophilic monomer, 0.1 to 10 parts of initiator, 0.1 to 10 parts of cross-linking agent, and 30 to 60 parts of solvent.

[0008] Preferably, in the above-mentioned high oxygen permeability silicone hydrogel, the small molecule silicone monomer includes one or more of methacryloxymethyltris(trimethylsiloxy)silane, methacryloxypropyltris(trimethylsiloxy)silane, γ-aminopropyltriethoxysilane, 3-(methacryloxy)propyltrimethoxysilane and 3-(3-methacryloxy-2-hydroxypropyl)propylbis(trimethylsiloxane)methylsilane.

[0009] Preferably, in the above-mentioned highly oxygen-permeable silicone hydrogel, the hydrophilic monomer includes one or more of hydroxyethyl methacrylate, N-vinyl pyrrolidone, methacrylic acid, methyl methacrylate, and polyethylene glycol methacrylate.

[0010] Preferably, in the above-mentioned highly oxygen-permeable silicone hydrogel, the initiator is azobisisobutyronitrile or benzoyl peroxide.

[0011] Preferably, in the above-mentioned highly oxygen-permeable silicone hydrogel, the crosslinking agent is one or more of polyethylene glycol diacrylate, ethylene glycol dimethacrylate, and triallyl isocyanurate.

[0012] Preferably, in the above-mentioned highly oxygen-permeable silicone hydrogel, the solvent is one or more of n-butanol, n-hexanol, n-nonanol and isopropanol.

[0013] The present invention also provides a method for preparing a highly oxygen permeable silicone hydrogel corneal contact lens, comprising the following steps:

[0014] The hydroxyl-terminated polydimethylsiloxane, small molecule silicon monomer, hydrophilic monomer, initiator, cross-linking agent and solvent are mixed and stirred in a formula, and then injected into a corneal contact lens mold to carry out a polymerization reaction; after the polymerization reaction is completed, the mold is placed in an alcohol solution for separation, and an intermediate is collected;

[0015] The intermediate is placed in an isopropanol solution for modification to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

[0016] Preferably, in the above method for preparing a highly oxygen-permeable silicone hydrogel corneal contact lens, the polymerization reaction temperature is 100 to 120° C., and the polymerization reaction time is 0.5 to 1.5 h.

[0017] It can be seen from the above technical solution that compared with the prior art, the present invention has the following beneficial effects:

[0018] (1) The present invention provides a highly oxygen permeable silicone hydrogel, comprising the following raw materials in parts by weight: 10 to 50 parts of hydroxyl-terminated polydimethylsiloxane, 10 to 50 parts of small molecule silicon monomer, 20 to 70 parts of hydrophilic monomer, 0.1 to 10 parts of initiator, 0.1 to 10 parts of cross-linking agent, and 30 to 60 parts of solvent. The introduction of small molecule silicon monomer can increase the compatibility between hydroxyl-terminated polydimethylsiloxane and hydrophilic monomer, and also help to improve the oxygen permeability of highly oxygen permeable silicone hydrogel; the hydroxyl group in hydroxyl-terminated polydimethylsiloxane is selected as a hydrophilic group, so that the hydroxyl-terminated polydimethylsiloxane has good hydrophilicity, and improves the compatibility between polydimethylsiloxane and hydrophilic monomer; the combined effect of hydroxyl-terminated polydimethylsiloxane, small molecule silicon monomer and hydrophilic monomer can improve the hydrophilicity of highly oxygen permeable silicone hydrogel and improve the oxygen permeability.

[0019] (2) In the present invention, high oxygen permeability silicone hydrogel can be obtained by mixing the raw materials for preparation and subjecting them to polymerization reaction. The preparation method is simple and is conducive to commercial promotion. DETAILED DESCRIPTION

[0020] The present invention provides a high oxygen permeability silicone hydrogel, comprising the following raw materials in parts by weight:

[0021] 10 to 50 parts of hydroxyl-terminated polydimethylsiloxane, 10 to 50 parts of small molecule silicon monomer, 20 to 70 parts of hydrophilic monomer, 0.1 to 10 parts of initiator, 0.1 to 10 parts of cross-linking agent, and 30 to 60 parts of solvent.

[0022] In the present invention, the mass fraction of the hydroxyl-terminated polydimethylsiloxane is preferably 10 to 50 parts, more preferably 15 to 48 parts, and even more preferably 20 to 30 parts.

[0023] In the present invention, the mass fraction of the small molecule silicon monomer is preferably 10 to 50 parts, more preferably 15 to 40 parts, and even more preferably 20 to 30 parts.

[0024] In the present invention, the mass fraction of the hydrophilic monomer is preferably 20 to 70 parts, more preferably 25 to 65 parts, and even more preferably 30 to 50 parts.

[0025] In the present invention, the weight percentage of the initiator is preferably 0.1 to 10 parts, more preferably 3 to 9 parts, and even more preferably 4 to 8 parts.

[0026] In the present invention, the weight percentage of the cross-linking agent is preferably 0.1 to 10 parts, more preferably 3 to 9 parts, and even more preferably 4 to 8 parts.

[0027] In the present invention, the mass fraction of the solvent is preferably 30 to 60 parts, more preferably 35 to 55 parts, and even more preferably 40 to 47 parts.

[0028] In the present invention, the small molecule silicon monomer preferably includes one or more of methacryloxymethyltris(trimethylsiloxy)silane, methacryloxypropyltris(trimethylsiloxy)silane, γ-aminopropyltriethoxysilane, 3-(methacryloxy)propyltrimethoxysilane and 3-(3-methacryloxy-2-hydroxypropyl)propylbis(trimethylsiloxane)methylsilane.

[0029] In the present invention, the hydrophilic monomer includes one or more of hydroxyethyl methacrylate, N-vinyl pyrrolidone, methacrylic acid, methyl methacrylate, and polyethylene glycol methacrylate.

[0030] In the present invention, the initiator is azobisisobutyronitrile or benzoyl peroxide.

[0031] In the present invention, the cross-linking agent is one or more of polyethylene glycol diacrylate, ethylene glycol dimethacrylate, and triallyl isocyanurate.

[0032] In the present invention, the solvent is one or more of n-butanol, n-hexanol, n-nonanol and isopropanol.

[0033] The present invention also provides a method for preparing a highly oxygen permeable silicone hydrogel corneal contact lens, comprising the following steps:

[0034] The hydroxyl-terminated polydimethylsiloxane, small molecule silicon monomer, hydrophilic monomer, initiator, cross-linking agent and solvent are mixed and stirred in a formula, and then injected into a corneal contact lens mold to carry out a polymerization reaction; after the polymerization reaction is completed, the mold is placed in an alcohol solution for separation, and an intermediate is collected;

[0035] The intermediate is placed in an isopropanol solution for modification to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

[0036] In the present invention, the polymerization reaction temperature is preferably 100-120°C, more preferably 105-117°C, more preferably 108-115°C; the polymerization reaction time is preferably 0.5-1.5h, more preferably 0.75-1.25h, more preferably 1h.

[0037] In the present invention, the alcohol solution is preferably one or more of methanol, ethanol, propanol, butanol or butanediol.

[0038] In the present invention, the concentration of the alcohol solution is preferably 20 to 30 wt %, more preferably 22 to 28 wt %, and even more preferably 25 to 27 wt %.

[0039] In the present invention, the concentration of the isopropanol solution is preferably 10 to 20 wt %, more preferably 12 to 18 wt %, and even more preferably 15 to 17 wt %.

[0040] In the present invention, the modification temperature is preferably 20-30°C, more preferably 22-28°C, and more preferably 24-25°C; the modification time is preferably 0.5-1h, more preferably 0.75-1h, and more preferably 1h.

[0041] In the present invention, after the modification is completed, the process further includes: soaking the obtained product in pure water, then replacing it in 0.9% saline for 30 minutes, and finally sealing it in a vial with 0.9% saline for sterilization to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

[0042] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0043] Example 1

[0044] A highly oxygen permeable silicone hydrogel comprising the following raw materials in parts by weight:

[0045] 45 parts of hydroxyl-terminated polydimethylsiloxane, 15 parts of small molecule silicon monomer, 50 parts of hydrophilic monomer, 5 parts of initiator, 6 parts of cross-linking agent, and 45 parts of solvent; wherein the small molecule silicon monomer is methacryloxymethyltris(trimethylsiloxy)silane, the hydrophilic monomer is polyethylene glycol methacrylate, the initiator is azobisisobutyronitrile, the cross-linking agent is polyethylene glycol diacrylate, and the solvent is n-butanol;

[0046] The hydroxyl-terminated polydimethylsiloxane, small molecule silicon monomer, hydrophilic monomer, initiator, cross-linking agent and solvent are mixed and stirred in a formula, and then injected into a corneal contact lens mold, and a polymerization reaction is carried out at 100° C. for 1.5 hours; after the polymerization reaction is completed, the mold is placed in a 20wt% methanol solution for separation, and an intermediate is collected;

[0047] The intermediate was placed in a 15wt% isopropanol solution at 23°C for modification for 1 hour. After the modification, the obtained product was immersed in pure water, then replaced in 0.9% saline for 30 minutes, and finally sealed in a vial with 0.9% saline and sterilized to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

[0048] Example 2

[0049] A highly oxygen permeable silicone hydrogel comprising the following raw materials in parts by weight:

[0050] 30 parts of hydroxyl-terminated polydimethylsiloxane, 10 parts of small molecule silicon monomer, 20 parts of hydrophilic monomer, 0.5 parts of initiator, 3 parts of cross-linking agent, and 30 parts of solvent; wherein the small molecule silicon monomer is γ-aminopropyltriethoxysilane, the hydrophilic monomer is N-vinylpyrrolidone, the initiator is azobisisobutyronitrile, the cross-linking agent is polyethylene glycol diacrylate, and the solvent is n-butanol;

[0051] The hydroxyl-terminated polydimethylsiloxane, small molecule silicon monomer, hydrophilic monomer, initiator, cross-linking agent and solvent are mixed and stirred in a formula, and then injected into a corneal contact lens mold, and a polymerization reaction is carried out at 120° C. for 0.5 h; after the polymerization reaction is completed, the mold is placed in a 20wt% methanol solution for separation, and an intermediate is collected;

[0052] The intermediate was placed in a 10wt% isopropanol solution at 23°C for modification for 1 hour. After the modification, the obtained product was immersed in pure water, then replaced in 0.9% saline for 30 minutes, and finally sealed in a vial with 0.9% saline and sterilized to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

[0053] Example 3

[0054] A highly oxygen permeable silicone hydrogel comprising the following raw materials in parts by weight:

[0055] 50 parts of hydroxyl-terminated polydimethylsiloxane, 40 parts of small molecule silicon monomer, 50 parts of hydrophilic monomer, 8 parts of initiator, 7 parts of cross-linking agent, and 45 parts of solvent; wherein the small molecule silicon monomer is 3-(3-methacryloyloxy-2-hydroxypropyl)propylbis(trimethylsiloxane)methylsilane, the hydrophilic monomer is methyl methacrylate, the initiator is azobisisobutyronitrile, the cross-linking agent is polyethylene glycol diacrylate, and the solvent is n-butanol;

[0056] The hydroxyl-terminated polydimethylsiloxane, small molecule silicon monomer, hydrophilic monomer, initiator, cross-linking agent and solvent are mixed and stirred in a formula, and then injected into a corneal contact lens mold, and a polymerization reaction is carried out at 100° C. for 1.5 hours; after the polymerization reaction is completed, the mold is placed in a 20wt% methanol solution for separation, and an intermediate is collected;

[0057] The intermediate was placed in a 10wt% isopropanol solution at 23°C for modification for 1 hour. After the modification, the obtained product was immersed in pure water, then replaced in 0.9% saline for 30 minutes, and finally sealed in a vial with 0.9% saline and sterilized to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

[0058] Example 4

[0059] A highly oxygen permeable silicone hydrogel comprising the following raw materials in parts by weight:

[0060] 30 parts of hydroxyl-terminated polydimethylsiloxane, 40 parts of small molecule silicon monomer, 20 parts of hydrophilic monomer, 8 parts of initiator, 5 parts of cross-linking agent, and 50 parts of solvent; wherein the small molecule silicon monomer is 3-(methacryloyloxy)propyltrimethoxysilane, the hydrophilic monomer is methacrylic acid, the initiator is azobisisobutyronitrile, the cross-linking agent is polyethylene glycol diacrylate, and the solvent is n-butanol;

[0061] The hydroxyl-terminated polydimethylsiloxane, small molecule silicon monomer, hydrophilic monomer, initiator, cross-linking agent and solvent are mixed and stirred in a formula, and then injected into a corneal contact lens mold, and a polymerization reaction is carried out at 115° C. for 0.5 h; after the polymerization reaction is completed, the mold is placed in a 20wt% methanol solution for separation, and an intermediate is collected;

[0062] The intermediate was placed in a 10wt% isopropanol solution at 23°C for modification for 1 hour. After the modification, the obtained product was immersed in pure water, then replaced in 0.9% saline for 30 minutes, and finally sealed in a vial with 0.9% saline and sterilized to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

[0063] Example 5

[0064] A highly oxygen permeable silicone hydrogel comprising the following raw materials in parts by weight:

[0065] 40 parts of hydroxyl-terminated polydimethylsiloxane, 20 parts of small molecule silicon monomer, 50 parts of hydrophilic monomer, 3 parts of initiator, 2 parts of cross-linking agent, and 30 parts of solvent; wherein the small molecule silicon monomer is methacryloxypropyl tris(trimethylsiloxane)silane, the hydrophilic monomer is hydroxyethyl methacrylate, the initiator is azobisisobutyronitrile, the cross-linking agent is polyethylene glycol diacrylate, and the solvent is n-butanol;

[0066] The hydroxyl-terminated polydimethylsiloxane, small molecule silicon monomer, hydrophilic monomer, initiator, cross-linking agent and solvent are mixed and stirred in a formula, and then injected into a corneal contact lens mold, and a polymerization reaction is carried out at 120° C. for 0.5 h; after the polymerization reaction is completed, the mold is placed in a 20wt% methanol solution for separation, and an intermediate is collected;

[0067] The intermediate was placed in a 10wt% isopropanol solution at 23°C for modification for 1 hour. After the modification, the obtained product was immersed in pure water, then replaced in 0.9% saline for 30 minutes, and finally sealed in a vial with 0.9% saline and sterilized to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

[0068] Comparative Example 1

[0069] A highly oxygen permeable silicone hydrogel comprising the following raw materials in parts by weight:

[0070] 45 parts of polydimethylsiloxane, 15 parts of small molecule silicon monomer, 50 parts of hydrophilic monomer, 5 parts of initiator, 6 parts of cross-linking agent, and 45 parts of solvent; wherein the small molecule silicon monomer is methacryloxymethyltris(trimethylsiloxy)silane, the hydrophilic monomer is polyethylene glycol methacrylate, the initiator is azobisisobutyronitrile, the cross-linking agent is polyethylene glycol diacrylate, and the solvent is n-butanol;

[0071] The hydroxyl-terminated polydimethylsiloxane, small molecule silicon monomer, hydrophilic monomer, initiator, cross-linking agent and solvent are mixed and stirred in a formula, and then injected into a corneal contact lens mold, and a polymerization reaction is carried out at 100° C. for 1.5 hours; after the polymerization reaction is completed, the mold is placed in a 20wt% methanol solution for separation, and an intermediate is collected;

[0072] The intermediate was placed in a 15wt% isopropanol solution at 23°C for modification for 1 hour. After the modification, the obtained product was immersed in pure water, then replaced in 0.9% saline for 30 minutes, and finally sealed in a vial with 0.9% saline and sterilized to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

[0073] Comparative Example 2

[0074] A highly oxygen permeable silicone hydrogel comprising the following raw materials in parts by weight:

[0075] 45 parts of hydroxyl-terminated polydimethylsiloxane, 50 parts of hydrophilic monomer, 5 parts of initiator, 6 parts of cross-linking agent, and 45 parts of solvent; wherein the hydrophilic monomer is polyethylene glycol methacrylate, the initiator is azobisisobutyronitrile, the cross-linking agent is polyethylene glycol diacrylate, and the solvent is n-butanol;

[0076] The hydroxyl-terminated polydimethylsiloxane, hydrophilic monomer, initiator, crosslinking agent and solvent are mixed and stirred in a formula, and then injected into a corneal contact lens mold, and a polymerization reaction is carried out at 100° C. for 1.5 hours; after the polymerization reaction is completed, the mold is placed in a 20wt% methanol solution for separation, and an intermediate is collected;

[0077] The intermediate was placed in a 15wt% isopropanol solution at 23°C for modification for 1 hour. After the modification, the obtained product was immersed in pure water, then replaced in 0.9% saline for 30 minutes, and finally sealed in a vial with 0.9% saline and sterilized to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

[0078] Performance Testing

[0079] The oxygen permeability values ​​of the corneal contact lenses of Examples 1 to 5 and Comparative Examples 1 to 2 were measured respectively by the coulometric method according to the national standard (GBT 11417.3-2012).

[0080] The moisture content of the corneal contact lenses of Examples 1 to 5 and Comparative Examples 1 to 2 was measured by weighing method, the weight of the glass slide was Q1, the weight of the lens and the glass slide was Q2, and after drying in an oven at 50°C to constant weight, the gross weight was G3, and the moisture content = (Q2-G3) / (Q2-Q1). The test results are listed in Table 1.

[0081] The elongation of the corneal contact lenses of Examples 1 to 5 and Comparative Examples 1 to 2 was tested using an electronic tensile testing machine XLW (PC). Each sample was clamped with a clamp for measurement, and the elongation at break of the corneal contact lens samples was measured. The above performance test results are shown in Table 1.

[0082] Table 1 Test results of high oxygen permeable silicone hydrogel contact lenses in Examples 1 to 5 and Comparative Examples 1 to 2

[0083]

[0084]

[0085] As shown in Table 1, the water content of the high oxygen permeable silicone hydrogel contact lenses prepared by the present invention is higher than 20%, and the elongation at break is greater than 150%, which is much better than the comparative samples, and the performance parameters meet the market standards. In particular, the oxygen permeability of the high oxygen permeable silicone hydrogel contact lenses is much better than that of the high oxygen permeable silicone hydrogel contact lenses prepared in the comparative examples, making them comfortable for human eyes to wear, and the preparation process is simple.

[0086] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A highly oxygen permeable silicone hydrogel, characterized in that: Contains the following raw materials by weight: 10 to 50 parts of hydroxyl-terminated polydimethylsiloxane, 10 to 50 parts of small molecule silicon monomer, 20 to 70 parts of hydrophilic monomer, 0.1 to 10 parts of initiator, 0.1 to 10 parts of cross-linking agent, and 30 to 60 parts of solvent.

2. The high oxygen permeability silicone hydrogel according to claim 1, characterized in that: The small molecule silicon monomer includes one or more of methacryloxymethyltris(trimethylsiloxy)silane, methacryloxypropyltris(trimethylsiloxy)silane, γ-aminopropyltriethoxysilane, 3-(methacryloxy)propyltrimethoxysilane and 3-(3-methacryloxy-2-hydroxypropyl)propylbis(trimethylsiloxane)methylsilane.

3. The high oxygen permeability silicone hydrogel according to claim 2, characterized in that: The hydrophilic monomer includes one or more of hydroxyethyl methacrylate, N-vinyl pyrrolidone, methacrylic acid, methyl methacrylate, and polyethylene glycol methacrylate.

4. The high oxygen permeability silicone hydrogel according to claim 3, characterized in that: The initiator is azobisisobutyronitrile or benzoyl peroxide.

5. The high oxygen permeability silicone hydrogel according to claim 4, characterized in that: The cross-linking agent is one or more of polyethylene glycol diacrylate, ethylene glycol dimethacrylate, and triallyl isocyanurate.

6. The high oxygen permeability silicone hydrogel according to claim 5, characterized in that: The solvent is one or more of n-butanol, n-hexanol, n-nonanol and isopropanol.

7. A method for preparing a highly oxygen permeable silicone hydrogel corneal contact lens, characterized in that: The following steps are involved: The hydroxyl-terminated polydimethylsiloxane, small molecule silicon monomer, hydrophilic monomer, initiator, cross-linking agent and solvent described in claim 1 are mixed and stirred evenly according to the formula amount, and then injected into a corneal contact lens mold to carry out a polymerization reaction; after the polymerization reaction is completed, the mold is placed in an alcohol solution for separation, and the intermediate is collected; The intermediate is placed in an isopropanol solution for modification to obtain a highly oxygen-permeable silicone hydrogel corneal contact lens.

8. The method for preparing a highly oxygen permeable silicone hydrogel contact lens according to claim 7, characterized in that: The polymerization reaction temperature is 100-120° C., and the polymerization reaction time is 0.5-1.5 h.

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