Method and device for detecting completeness of skin barrier

Abstract

The invention relates to a skin barrier integrity detection method, after pulse excitation is performed on skin cuticula through preset electric pulse intermittent type, the water content of skin is detected, and the skin barrier integrity is evaluated according to the change condition of the water content, the detection method comprises the following steps: configuring a group of positive and negative electrodes at the target spot skin; releasing an electric pulse through the electrode so as to carry out pulse excitation on the target spot skin; the electrode is used for detecting withstand voltage of sudden change of the water content of the target spot skin; gradually increasing the voltage of the electric pulse according to a preset rule, and alternately executing the two steps; a relation table between suddenly-changed withstand voltages; and automatically evaluating the completeness of the skin barrier according to the relation table. The invention further provides a detection device capable of executing the steps. According to the detection method and device, the target position can be directly detected and judged, so that the requirement on the diagnosis experience of a doctor is greatly reduced.

Description

Technical Field

[0001] The invention relates to the technical field of skin care and health care, and in particular to a method and device for detecting the integrity of a skin barrier. Background Art

[0002] In the fields of skin disease treatment, transdermal drug delivery, medical cosmetology, etc., the skin barrier status of patients or users has a crucial impact on the treatment or medication plan.

[0003] Traditional judgment of skin barrier status mainly relies on subjective judgment, which is uncertain and subjective. With the emergence of instruments related to skin physiological indicators, indirect indicators such as moisture on the skin surface, transepidermal water loss, and oil measured by instruments have become an important means of comprehensively judging the skin barrier status. In recent years, skin imaging detection technology and spectral detection technology have also provided reliable indirect diagnostic indicators for skin barrier detection. However, although the above detection methods can provide detection data of different dimensions, these data can only serve as indirect basis for doctors to judge the skin barrier status, and the accuracy of the diagnosis results is extremely dependent on the doctor's understanding of the equipment, data and diagnostic experience. Summary of the invention

[0004] Based on this, it is necessary to provide a method and device for detecting the integrity of the skin barrier, which can directly detect and judge the target position, thereby greatly reducing the requirements for the doctor's diagnostic experience.

[0005] In order to achieve the above-mentioned object of the invention, the present invention adopts the following technical solutions.

[0006] The present invention provides a method for detecting the integrity of the skin barrier, which detects the water content of the skin after intermittently pulse-exciting the stratum corneum of the skin by preset electric pulses, and evaluates the integrity of the skin barrier according to the change of the water content. The detection method comprises the steps of:

[0007] S1: A set of positive and negative electrodes are configured at the target skin;

[0008] S2: releasing electric pulses through the electrodes to pulse stimulate the target skin;

[0009] S3: using the electrode to detect the withstand voltage of a sudden change in the water content of the target skin;

[0010] S4: gradually increasing the voltage of the electric pulse according to a predetermined rule, and performing steps S2-S3 alternately;

[0011] S5: Obtain a relationship table between the voltage of the electric pulse and the tolerance voltage at which the water content of the target skin undergoes a sudden change; and automatically evaluate the integrity of the skin barrier according to the relationship table.

[0012] Preferably, step S1 specifically includes:

[0013] If there is more than one target skin point, a set of positive and negative electrodes is respectively configured at each target skin point.

[0014] Preferably, step S2 specifically includes:

[0015] The electric pulse is a square wave pulse.

[0016] Preferably, step S4 specifically includes:

[0017] The initial voltage of the electric pulse was 5V and the maximum voltage was 35V.

[0018] Preferably, step S4 specifically includes:

[0019] Baseline data collection is continued for a period of time at the initial voltage to obtain reference data under the initial state;

[0020] The voltage of the electric pulse is gradually increased to stimulate the target skin with electric pulses until the water content of the target skin undergoes a sudden change;

[0021] Steps S2 and S3 are performed alternately.

[0022] Preferably, the step of gradually increasing the voltage of the electric pulse to excite the target skin with the electric pulse until the water content of the target skin changes suddenly comprises:

[0023] The voltage of the electric pulse is increased at regular intervals.

[0024] Preferably, step S5 specifically includes:

[0025] The data of the relationship table between the voltage of the electric pulse and the tolerance voltage of the sudden change of the water content of the target skin are fitted, and the clinical experiments and diagnosis results are analyzed and summarized to classify the skin barrier.

[0026] The present invention also provides a detection device for the integrity of the skin barrier, which detects the water content of the skin after intermittently pulse-exciting the stratum corneum of the skin by a preset electric pulse, and evaluates the integrity of the skin barrier according to the change of the water content. The detection device includes an input-output circuit, a switching circuit and at least one set of positive and negative electrodes, wherein:

[0027] The positive and negative electrodes are arranged at the target skin;

[0028] The input-output circuit includes an electric pulse excitation module and a skin water content detection module, both of which are connected to the positive and negative electrodes; the electric pulse excitation module is used to release electric pulses to perform pulse excitation on the target skin, and the skin water content detection module is used to detect the withstand voltage of a sudden change in the water content of the target skin.

[0029] The device also includes a control module, which is connected to the input-output circuit, gradually increases the voltage of the electric pulse according to a predetermined rule, and switches the electric pulse excitation module and the skin water content detection module to alternately perform the pulse excitation step and the skin water content detection step.

[0030] It also includes a host computer connected to the control module, which is used to obtain a relationship table between the voltage of the electric pulse and the withstand voltage of the sudden change of the water content of the target skin, and automatically evaluate the integrity of the skin barrier according to the relationship table. Preferably, the control module is also used to:

[0031] Baseline data collection is continued for a period of time at the initial voltage to obtain reference data at the initial state;

[0032] The voltage of the electric pulse is gradually increased to stimulate the target skin with electric pulses until the water content of the target skin undergoes a sudden change;

[0033] The pulse excitation step and the skin water content detection step are performed alternately.

[0034] The present invention continuously detects the skin through the above technical solution. During this period, the stratum corneum of the skin is intermittently stimulated by electric pulses through a preset electric pulse wave. During the stimulation process, the stratum corneum of the skin will eventually form a reversible water channel. After the water channel is formed, it will be connected with the hydrolipid film on the surface of the stratum corneum. When the detected water content increases sharply, it is determined to be a mutation. By judging the time and / or voltage threshold that causes the skin water content to change suddenly, the tolerance and integrity of the skin barrier can be evaluated. On this basis, by combining clinical diagnosis results and data algorithms, the integrity of the skin barrier can be automatically evaluated. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 Schematic diagram of the process of the method for detecting skin barrier integrity in this embodiment;

[0036] Figure 2 4 is a structural block diagram of the skin barrier integrity detection device in this embodiment.

[0037] The realization of the purpose of the present invention and its functions and principles will be further explained in the specific implementation manner in conjunction with the accompanying drawings. DETAILED DESCRIPTION

[0038] The following is a further description with reference to the accompanying drawings and specific embodiments.

[0039] This embodiment provides a method for detecting the integrity of the skin barrier. The "skin barrier" is an important protective layer on the outside of the human skin epidermis. It can prevent the loss of water and electrolytes in the body, prevent the invasion of the external environment, and help maintain the body's homeostasis. It is composed of a "brick wall structure" composed of keratinocytes and intercellular lipids and a hydrolipid film covering the "brick wall structure". Under the action of a pulsed electric field of a certain frequency, the keratinocytes and intercellular lipids of the skin will form instantaneous micro water channels. As long as the intensity of the electric pulse excitation is properly controlled, the water channels formed are instantaneously reversible to ensure the safety of the technology.

[0040] like Figure 1 As shown, in this embodiment, after intermittently pulse-stimulating the stratum corneum of the skin by preset electric pulses, the water content of the skin is detected, and the integrity of the skin barrier is evaluated according to the water content. The detection method includes the steps of:

[0041] S1: A set of positive and negative electrodes are configured at the target skin;

[0042] S2: releasing electric pulses through the electrodes to pulse stimulate the target skin;

[0043] S3: using the electrode to detect the withstand voltage of a sudden change in the water content of the target skin;

[0044] S4: gradually increasing the voltage of the electric pulse according to a predetermined rule, and performing steps S2-S3 alternately;

[0045] S5: Obtain a relationship table between the voltage of the electric pulse and the tolerance voltage at which the water content of the target skin undergoes a sudden change; and automatically evaluate the integrity of the skin barrier according to the relationship table.

[0046] Wherein, step S1 specifically includes: if there is more than one target skin point, a group of positive and negative electrodes are respectively configured at each target skin point.

[0047] Step S2 specifically includes: the electric pulse is a square wave pulse, the pulse frequency is between 100 Hz and 1000 Hz, the pulse width is between 0.02 ms and 1 ms, and the pulse interval is between 0.1 ms and 10 s.

[0048] Step S4 specifically includes: the initial voltage of the electric pulse is 5V, and the maximum voltage is 35V. Baseline data is collected for a period of time at the initial voltage to obtain reference data in the initial state; the voltage of the electric pulse is gradually increased to stimulate the target skin with electric pulses until the water content of the target skin changes suddenly; steps S2 and S3 are performed alternately and repeated 2 to 30 times.

[0049] Step S5 specifically includes:

[0050] The data of the relationship table between the voltage of the electric pulse and the tolerance voltage of the sudden change of the water content of the target skin are fitted, and the clinical experiments and diagnosis results are analyzed and summarized to classify the skin barrier.

[0051] Among them, the step of gradually increasing the voltage of the electric pulse to stimulate the target skin with electric pulses until the water content of the target skin changes suddenly specifically includes: a series of pulse groups with different voltages designed with a timing sequence, and the voltage of the pulse group from the 1st to the Nth wave is gradually increased to apply a gradually enhanced electric pulse stimulation effect to the skin.

[0052] The automatic evaluation algorithm for skin barrier integrity uses a capacitance curve fitting and comparison method. By fitting, predicting, and comparing the rate of change of skin water content, the energy intensity required for the skin to reach a transparent state after being stimulated by electric pulses is evaluated. The corresponding relationship between the energy intensity level required for the skin to reach the transparent state and the skin integrity level is summarized in combination with clinical experiments and diagnostic results to complete the automatic evaluation of skin barrier integrity.

[0053] Reference Figure 2 As shown, this embodiment also provides a skin barrier integrity detection device 100, which detects the water content of the skin after intermittently pulse-exciting the skin stratum corneum with a preset electric pulse, and evaluates the integrity of the skin barrier according to the change of the water content. The detection device includes an input-output circuit 10, a switching circuit 20 and at least one set of positive and negative electrodes 30, wherein:

[0054] The positive and negative electrodes 30 are array electrodes and are arranged at the target skin 200; if there is more than one target skin 200, a group of positive and negative electrodes 30 is configured at each target skin 200.

[0055] The input-output circuit 10 includes an electric pulse excitation module and a skin water content detection module, and the electric pulse excitation module and the skin water content detection module are respectively connected to the positive and negative electrodes 30, including two situations of connecting to the same positive and negative electrodes 30 and connecting to different positive and negative electrodes 30. The electric pulse excitation module is used to release electric pulses to perform pulse excitation on the target skin 200, and the skin water content detection module is used to detect the withstand voltage of the sudden change of the water content of the target skin 200.

[0056] It also includes a control module 40, which is connected to the input-output circuit 10, gradually increases the voltage of the electric pulse according to a predetermined rule, and switches the electric pulse excitation module and the skin moisture content detection module to alternately execute the pulse excitation step and the skin moisture content detection step, that is, detection waveform-pulse excitation waveform-detection waveform-pulse excitation waveform..., and outputs in a cycle.

[0057] It also includes a host computer 50 connected to the control module 40, for obtaining a relationship table between the voltage of the electric pulse and the tolerance voltage of the sudden change of the water content of the target skin 200, and automatically evaluating the integrity of the skin barrier according to the relationship table.

[0058] The electric pulse is a square wave pulse, the pulse frequency is between 100 Hz and 1000 Hz, the pulse width is adjustable from 0.02 ms to 1 ms, and the pulse interval is adjustable from 0.1 ms to 10 s.

[0059] The control module 40 is also used for:

[0060] Baseline data collection is continued for a period of time at the initial voltage to obtain reference data at the initial state;

[0061] The voltage of the electric pulse is gradually increased to excite the target skin 200 with the electric pulse until the water content of the target skin 200 undergoes a sudden change;

[0062] The pulse excitation step and the skin water content detection step are performed alternately and repeated 2 to 30 times.

[0063] In summary, the present invention continuously detects the skin through the above technical solution. During this period, the stratum corneum of the skin is intermittently stimulated by electric pulses through a preset electric pulse waveform. During the stimulation process, the stratum corneum of the skin will eventually form a reversible water channel. After the water channel is formed, it will be connected to the hydrolipid film on the surface of the stratum corneum. When the detected water content increases sharply, it is determined to be a mutation. By judging the time and / or voltage threshold that causes the skin water content to mutate, the tolerance and integrity of the skin barrier can be evaluated. On this basis, by combining clinical diagnosis results and data algorithms, the integrity of the skin barrier can be automatically evaluated.

[0064] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0065] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A method for detecting the integrity of the skin barrier, which comprises intermittently stimulating the stratum corneum of the skin with a preset electric pulse, detecting the water content of the skin, and evaluating the integrity of the skin barrier according to the change of the water content, characterized in that: The detection method comprises the steps of: S1: A set of positive and negative electrodes are configured at the target skin; S2: releasing electric pulses through the electrodes to pulse stimulate the target skin; S3: using the electrode to detect the withstand voltage of a sudden change in the water content of the target skin; S4: gradually increasing the voltage of the electric pulse according to a predetermined rule, and performing steps S2-S3 alternately; S5: Obtain a relationship table between the voltage of the electric pulse and the tolerance voltage at which the water content of the target skin undergoes a sudden change; and automatically evaluate the integrity of the skin barrier according to the relationship table.

2. The detection method according to claim 1, characterized in that Step S1 specifically includes: If there is more than one target skin point, a set of positive and negative electrodes is respectively configured at each target skin point.

3. The detection method according to claim 1, characterized in that Step S2 specifically includes: The electric pulse is a square wave pulse.

4. The detection method according to claim 3, characterized in that Step S4 specifically includes: The initial voltage of the electric pulse was 5V and the maximum voltage was 35V.

5. The detection method according to claim 1 or 4, characterized in that: Step S4 specifically includes: Baseline data collection is continued for a period of time at the initial voltage to obtain reference data under the initial state; The voltage of the electric pulse is gradually increased to stimulate the target skin with electric pulses until the water content of the target skin undergoes a sudden change; Steps S2 and S3 are performed alternately.

6. The detection method according to claim 5, characterized in that The step of gradually increasing the voltage of the electric pulse to excite the target skin with the electric pulse until the water content of the target skin undergoes a sudden change specifically includes: The voltage of the electric pulse is increased at regular intervals.

7. The detection method according to claim 5, characterized in that: Step S5 specifically includes: The data of the relationship table between the voltage of the electric pulse and the tolerance voltage of the sudden change of the water content of the target skin are fitted, and the clinical experiments and diagnosis results are analyzed and summarized to classify the skin barrier.

8. A device for detecting the integrity of the skin barrier, which detects the water content of the skin after intermittently stimulating the stratum corneum of the skin with a preset electric pulse, and evaluates the integrity of the skin barrier according to the change of the water content, characterized in that: The detection device comprises an input-output circuit, a switching circuit and at least one set of positive and negative electrodes, wherein: The positive and negative electrodes are arranged at the target skin; The input-output circuit includes an electric pulse excitation module and a skin water content detection module, and the electric pulse excitation module and the skin water content detection module are respectively connected to the positive and negative electrodes; the electric pulse excitation module is used to release electric pulses to perform pulse excitation on the target skin, and the skin water content detection module is used to detect the withstand voltage of a sudden change in the water content of the target skin. The device also includes a control module, which is connected to the input-output circuit, gradually increases the voltage of the electric pulse according to a predetermined rule, and switches the electric pulse excitation module and the skin water content detection module to alternately perform the pulse excitation step and the skin water content detection step. It also includes a host computer connected to the control module, which is used to obtain a relationship table between the voltage of the electric pulse and the tolerance voltage of a sudden change in the water content of the target skin, and automatically evaluate the integrity of the skin barrier based on the relationship table.

9. The detection device according to claim 8, characterized in that: The control module is also used for: Baseline data collection is continued for a period of time at the initial voltage to obtain reference data under the initial state; The voltage of the electric pulse is gradually increased to stimulate the target skin with electric pulses until the water content of the target skin undergoes a sudden change; The pulse excitation step and the skin water content detection step are performed alternately.

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