Improved multipurpose pipeline for artificial liver blood purification

Abstract

The invention discloses an improved multipurpose pipeline for artificial liver blood purification. A basic treatment unit comprises an output pipeline, an input pipeline, a first separator, a plasma pipeline and a fluid infusion port; one end of the first separator is connected with the output pipeline, and the other end of the first separator is connected with the input pipeline; the side wall of the first separator is connected with a plasma pipeline; one end of the input pipeline is communicated with the liquid supplementing port; a first discharge port is formed in one end of the plasma pipeline; the first additional unit comprises an injection pipe, a second separator and a relay pipeline; one end of the second separator is connected with the plasma pipeline through an injection pipe, and the other end of the second separator is connected with the input pipeline through a relay pipeline; the second additional unit comprises a side output pipe and a first conveying pipe; one end of the side output pipe is communicated with the second separator, and the other end is communicated with the input pipeline; one end of the first conveying pipe is communicated with the relay pipeline, and the other end is provided with a second discharge port.

Description

Technical Field

[0001] The invention belongs to the technical field of medical devices, and in particular relates to an improved multi-purpose pipeline for artificial liver blood purification. Background Art

[0002] Artificial liver blood purification treatment technology is an important means of treating liver failure. Its treatment is to complete the functions of separation, replacement, adsorption and material exchange through the extracorporeal circulation system, temporarily replace some liver functions, remove harmful substances, supplement essential substances, create conditions for liver cell regeneration, and can also become a bridge for liver transplantation. The artificial liver treatment process is complex and highly operational. The installation and pre-flushing of the extracorporeal circulation circuit before treatment are completed by the operating nurse, which is a large workload. With the continuous updating of artificial liver blood purification treatment modes and technologies, the existing fixed mode matching circuits cannot fully meet the needs of current clinical treatment development and change. Therefore, there will be a phenomenon of using two sets of circuits to achieve a complex treatment or carry out new treatments. This kind of pipeline connection method, on the one hand, increases the workload of the operator, increases the operation links, and increases the risk of contamination; on the other hand, it increases the complexity and difficulty of nursing operations, making it difficult to achieve homogeneity of clinical nursing operation quality, further increasing the risk of treatment and affecting the safety of treatment. It even restricts the development of complex and new modes to some extent.

[0003] In view of the above problems, the present invention provides an improved multi-purpose pipeline for artificial liver blood purification. Summary of the invention

[0004] In order to overcome the problems mentioned in the background art, the present invention provides an improved multi-purpose pipeline for artificial liver blood purification.

[0005] An improved multi-purpose pipeline for artificial liver blood purification, comprising: A basic treatment unit, comprising an output pipeline, an input pipeline, a first separator, a plasma pipeline and a fluid infusion port; one end of the first separator is connected to the output pipeline, and the other end is connected to the input pipeline; the side wall of the first separator is connected to the plasma pipeline; one end of the input pipeline is in communication with the fluid infusion port; a fluid infusion valve is provided on the fluid infusion port; a first discharge port is provided at one end of the plasma pipeline away from the first separator; and a first discharge valve is provided on the first discharge port; The first additional unit includes an injection tube, a second separator and a relay pipeline; one end of the second separator is connected to the plasma pipeline through the injection tube, and the other end is connected to the input pipeline through the relay pipeline; an injection valve is provided inside the injection tube; The second additional unit comprises a side output pipe and a first delivery pipe; one end of the side output pipe is connected to the second separator, and the other end is connected to the input pipeline; one end of the first delivery pipe is connected to the relay pipeline, and the other end is provided with a second discharge port; the second discharge port is provided with a second discharge valve; the first delivery pipe is provided with a first delivery valve; the side output pipe is provided with a first side output valve; The third additional unit comprises a circulation pipeline; one end of the circulation pipeline is connected to the side output pipe, and the other end is connected to the side wall of the second separator; a first circulation valve and a second circulation valve are arranged inside the circulation pipeline.

[0006] Furthermore, it also includes a reflux pipeline; one end of the reflux pipeline is connected to the input pipeline, and the other end is connected to the fluid infusion port.

[0007] Furthermore, a second side output valve, a third side output valve and a four-way joint are provided inside the side output pipe; the four-way joint is connected in series inside the side output pipe and is located between the second side output valve and the third side output valve; the other two interfaces of the four-way joint are connected in series inside the relay pipeline; the first side output valve is located between the second side output valve and the second separator.

[0008] Furthermore, the connection point between the circulation pipeline and the side output pipe is between the first delivery valve and the second delivery valve.

[0009] Furthermore, the side output pipe is connected to the input pipeline through a return slurry pump.

[0010] Furthermore, the relay pipeline includes a relay pipe body, a second delivery pipe and a third delivery pipe; the relay pipe body, the second delivery pipe and the third delivery pipe are connected by a four-way joint; one end of the second delivery pipe away from the relay pipe body is connected to the side output pipe; one end of the third delivery pipe is connected to the side output pipe, and the other end is connected to the input pipeline; a second delivery valve is provided inside the second delivery pipe; a fourth delivery valve is provided inside the third delivery pipe.

[0011] Furthermore, a first pump body is provided inside the output pipeline.

[0012] Furthermore, a second pump body is provided inside the plasma pipeline.

[0013] Furthermore, a third pump body is provided inside the circulation pipeline.

[0014] Furthermore, an adsorption device is provided inside the circulation pipeline.

[0015] Beneficial effects of the present invention: 1. PE treatment, i.e. plasma exchange treatment, can be performed using the basic treatment unit. During the treatment, the patient's blood enters the first separator through the output pipeline. The first separator separates the plasma components and cell components in the whole blood according to a certain ratio, and the plasma is discharged through the plasma pipeline and the first discharge port. The cell components separated by the first separator enter the input pipeline through the first output pipe, and at the same time, the supplementary fluid (plasma / plasma substitute) enters the input pipeline from the fluid replenishment port. After the supplementary fluid is mixed with the cell components, it is returned to the human body through the input pipeline. 2. Open the injection valve and close the first discharge valve to connect the basic treatment unit with the first additional unit, so that adsorption therapy can be performed, such as DPMAS, bilirubin adsorption therapy, plasma perfusion therapy, etc. During the treatment, the patient's blood enters the first separator through the output pipeline, and part of the plasma is separated from the whole blood by the first separator. The plasma enters the second separator through the plasma pipeline. After the plasma passes through the second separator and completes adsorption / perfusion, it is injected into the input pipeline through the relay pipeline; the cell components separated by the first separator enter the input pipeline through the first output pipe and are mixed with the plasma after the adsorption / perfusion is completed, and the input pipeline returns to the human body; 3. Open the first delivery valve, the first side output valve, the second side output valve, the third side output valve, and the second discharge valve, and close the second delivery valve, so that the basic treatment unit is connected with the first additional unit and the second additional unit, and DFPP treatment, i.e., double plasma exchange, can be performed; during the treatment process, the patient's blood enters the first separator through the output pipeline, the first separator separates blood cells from plasma, the plasma enters the second separator through the plasma pipeline, the plasma separated by the second separator flows through the plasma component separator with a pore size smaller than that of the plasma separator, and the molecules in the plasma that are larger than the pore size of the plasma component separator membrane cannot pass through the second membrane pore and are intercepted and discharged through the second discharge port; the cell components separated by the first separator enter the input pipeline through the first output pipe, and at the same time, the plasma filtered by the second separator enters the input pipeline through the side output pipe, and the infusion port replenishes the replacement fluid (plasma, albumin solution, other plasma substitutes, etc.) to the input pipeline, and after the filtered plasma, replacement fluid, and cell components are mixed, they return to the human body through the input pipeline; 4. Open the first circulation valve and the second circulation valve, close the second discharge valve and the second side output valve, and then connect the basic treatment unit with the first additional unit, the second additional unit, and the third additional unit, so that a new adsorption treatment can be performed; during the treatment process, the patient's blood enters the first separator through the output pipeline, and the first separator 5 separates part of the plasma from the whole blood. The plasma enters the second separator through the plasma pipeline, and then enters the input pipeline through the relay pipeline. The blood cells separated by the first separator enter the input pipeline through the first output pipe, and the filtered plasma is mixed with the cell components and returned to the human body through the input pipeline; when the adsorption device is an adsorber, the second separator is a plasma component separator. At this time, the intercepted macromolecular substances in the plasma that are larger than the pore size of the plasma component separator membrane enter the adsorption device after passing through the circulation pipeline, and the adsorption treatment is repeated. When the adsorption device is a biological device, the second separator is a plasma component separator or a cell filter. The biological materials in the biological device can repeatedly enter the second separator through the circulation pipeline, which plays a role in preventing biological cell components from entering the body; 5. In summary, the present invention can control the connection and closing of different pipelines through the switching of different valves on a single pipeline, implement different treatment plans, effectively reduce the operator's workload and operation links, and reduce the risk of pollution; reduce the difficulty of nursing operations, achieve homogeneity of clinical nursing operation quality, and further ensure treatment safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 A schematic diagram of the structure of a multi-purpose pipeline for implementing the present invention; Figure 2 It is a structural schematic diagram of a first use mode of the multi-purpose pipeline of the present invention; Figure 3 A schematic diagram of a second use method of the multi-purpose pipeline of the present invention; Figure 4 It is a structural schematic diagram of a third use mode of the multi-purpose pipeline of the present invention; Figure 5 It is a structural schematic diagram of a fourth use mode of the multi-purpose pipeline of the present invention; In the figure, 1, human body; 2, output pipeline; 3, input pipeline; 4, return pipeline; 5, first separator; 6, plasma pipeline; 7, second separator; 8, relay pipeline; 9, circulation pipeline; 10, fluid infusion port; 21, first fluid infusion port; 22, first sampling port; 23, first pump body; 24, anticoagulation port; 25, arterial pot; 31, venous pot; 32, detector; 33, second sampling port; 34, second pressure detection port; 41, return plasma pump; 42, heater; 401, first return valve; 402, second return valve; 51, first output pipe; 52, separator pressure measuring port; 61, first discharge port; 62, blood leakage detection component; 63, second pump body; 64 , plasma jug; 601, first discharge valve; 641, plasma pressure measuring port; 71, injection tube; 72, side output tube; 711, injection valve; 721, first side output valve; 722, second side output valve; 723, third side output valve; 801, first delivery pipe; 802, second delivery pipe; 803, second delivery valve; 804, third delivery valve; 805, fourth delivery valve; 806, third delivery pipe; 807, first delivery valve; 808, four-way connector; 91, second discharge port; 92, circulation sampling port; 93, third pump body; 95, adsorption device; 911, second discharge valve; 901, first circulation valve; 902, second circulation valve; 101, rehydration valve. DETAILED DESCRIPTION

[0017] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. The present invention can also be implemented or applied through other different specific implementation methods. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0018] In the description of the present invention, it is necessary to understand that the terms "upper", "lower", "front", "back", "inside", "outside", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0019] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0020] Example 1

[0021] like Figure 1 An improved multi-purpose pipeline for artificial liver blood purification is shown, comprising: The basic treatment unit comprises an output pipeline 2, an input pipeline 3, a first separator 5, a plasma pipeline 6 and a fluid infusion port 10; one end of the first separator 5 is connected to the output pipeline 2, and the other end is connected to the input pipeline 3; the side wall of the first separator 5 is connected to the plasma pipeline 6; one end of the input pipeline 3 is in communication with the fluid infusion port 10; a fluid infusion valve 101 is provided on the fluid infusion port 10; a first discharge port 61 is provided at one end of the plasma pipeline 6 away from the first separator 5; a first discharge valve 601 is provided on the first discharge port 61; The first additional unit includes an injection tube 71, a second separator 7 and a relay pipeline 8; one end of the second separator 7 is connected to the plasma pipeline 6 through the injection tube 71, and the other end is connected to the input pipeline 3 through the relay pipeline 8; an injection valve 711 is provided inside the injection tube 71; The second additional unit includes a side output pipe 72 and a first delivery pipe 801; one end of the side output pipe 72 is connected to the second separator 7, and the other end is connected to the input pipeline 3; one end of the first delivery pipe 801 is connected to the relay pipeline 8, and the other end is provided with a second discharge port 91; the second discharge port 91 is provided with a second discharge valve 911; the first delivery pipe 801 is provided with a first delivery valve 807; the side output pipe 72 is provided with a first side output valve 721; The third additional unit includes a circulation pipeline 9; one end of the circulation pipeline 9 is connected to the side output pipe 72, and the other end is connected to the side wall of the second separator 7; a first circulation valve 901 and a second circulation valve 902 are arranged inside the circulation pipeline 9.

[0022] The reflux pipeline 4 has one end connected to the input pipeline 3 and the other end connected to the fluid infusion port 10 .

[0023] Furthermore, a second side output valve 722, a third side output valve 723 and a four-way joint 808 are provided inside the side output pipe 72; the four-way joint 808 is connected in series inside the side output pipe 72, and is located between the second side output valve 722 and the third side output valve 723; the other two interfaces of the four-way joint 808 are connected in series inside the relay pipeline 8; the first side output valve 721 is located between the second side output valve 722 and the second separator 7.

[0024] Specifically, the connection point between the circulation pipeline 9 and the side output pipe 72 is between the first delivery valve 807 and the second delivery valve 803 .

[0025] The side output pipe 72 is connected to the input pipeline 3 through the return pump 41. The liquid in the side output pipe 72 can be pumped into the input pipeline 3 by turning on the return pump 41.

[0026] Furthermore, the relay pipeline 8 includes a relay pipe body, a second delivery pipe 802 and a third delivery pipe 806; the relay pipe body, the second delivery pipe 802 and the third delivery pipe 806 are connected via a four-way joint 808; one end of the second delivery pipe 802 away from the relay pipe body is connected to the side output pipe 72; one end of the third delivery pipe 806 is connected to the side output pipe 72, and the other end is connected to the input pipeline 3; a second delivery valve 803 is provided inside the second delivery pipe 802; a fourth delivery valve 805 is provided inside the third delivery pipe 806.

[0027] Specifically, one end of the third delivery pipe 806 is in communication with the side output pipe 72 , and the other end is in communication with the return pipe 4 . The end of the side output pipe 72 away from the second separator 7 is in communication with the return pipe 4 .

[0028] Specifically, the four-way joint 808 is connected in series inside the side output pipe 72, and is located between the second side output valve 722 and the third side output valve 723; the other two interfaces of the four-way joint 808 are respectively connected to the second delivery pipe 802 and the third delivery pipe 806. Through the third delivery pipe 806, the liquid can bypass the return slurry pump 41 and enter the input pipeline 3.

[0029] Specifically, the output pipeline 2 is provided with a first pump body 23 and an arterial pot 25. The first pump body 23 continuously sucks blood from the patient's body through the output pipeline 2 and passes through the arterial pot 25. The arterial pot 25 is connected to the first separator 5. The blood in the arterial pot 25 enters the first separator 5. The first separator 5 separates the blood into plasma and cell components. The cell components enter the input pipeline 3 through the first output pipe 51 and flow back into the human body 1. The plasma separated by the first separator 5 enters the plasma pipeline 6.

[0030] Specifically, the cell components enter the input line 3 through the first output tube 51, the venous pot 31, and the bubble detector 32 in sequence and flow back into the human body 1. In some embodiments of the present application, a first fluid infusion port 21 is further provided inside the output pipeline 2 , and replacement fluid can be added into the output pipeline 2 through the first fluid infusion port 21 .

[0031] Preferably, an anticoagulation port 24 is further provided inside the output pipeline 2, and the anticoagulation port 24 is connected to a first anticoagulation pump to prevent blood from coagulating during extracorporeal circulation.

[0032] Furthermore, a first sampling port 22 is provided inside the output pipeline 2, and a patient's blood sample can be collected through the first sampling port 22 for detection and analysis.

[0033] Furthermore, a pressure detection device is provided inside the output pipeline 2 to detect the blood pressure / arterial pressure inside the output pipeline 2 .

[0034] In the exemplary embodiment of the present application, a second pump body 63 is provided inside the plasma pipeline 6. The second pump body 63 draws the plasma out of the first separator 5. At this time, the first discharge valve 601 is opened, the injection valve 711 is closed, and the plasma is discharged through the first discharge port 61. The injection valve 711 is opened, and the first discharge valve 601 is closed, so that the basic treatment unit is connected with the first additional unit, and the plasma can enter the second separator 7 along the injection pipe 71.

[0035] Furthermore, a blood leakage detection component 62 is provided inside the plasma pipeline 6 to automatically detect whether the membrane of the first separator 5 is broken.

[0036] Furthermore, a plasma pot 64 is provided inside the plasma pipeline 6 , and the second pump body 63 sucks the plasma out of the first separator 5 and stores / passes into the plasma pot 64 .

[0037] Preferably, a plasma pressure measuring port 641 is provided on the plasma jug 64 , and the pressure inside the plasma jug 64 can be measured through the plasma pressure measuring port 641 , thereby obtaining the internal pressure data of the plasma pipeline 6 .

[0038] In some examples of the present application, a third pump body 93 is provided inside the circulation pipeline 9. The function of the third pump body 93 is to maintain the circulation of the liquid inside the circulation pipeline 9.

[0039] In the specific example of the present application, an adsorption device 95 is also provided inside the circulation pipeline 9. During the circulation process, the liquid inside the circulation pipeline 9 brings out the filtrate intercepted by the second separator 7 and transports it to the inside of the adsorption device 95 to maintain the filtration capacity and filtration effect of the second separator 7.

[0040] The input pipeline 3 is provided with a venous pot 31, a detector 32 and a second sampling port 33; the cell components separated by the first separator 5 enter the venous pot 31 through the first output pipe 51, and the supplementary fluid (plasma / albumin solution / plasma bag supplies, etc.) transmitted by the return pipeline 4 also enters the venous pot 31. After the cell components and plasma are mixed inside the venous pot 31, they will enter the human body 1 through the input pipeline 3.

[0041] The venous pot 31 is detachably connected to the input pipeline 3. When the venous pot 31 bleeds, that is, when the second pressure detection port 34 on the venous pot 31 detects that the internal pressure of the venous pot 31 increases, the first output pipe 51, the return pipeline 4, and the input pipeline 3 are cut off, and a new venous pot 31 is replaced.

[0042] The function of the detector 32 is: Detect whether there is too little liquid in the intravenous pot 31, or even the intravenous pot 31 is empty. Detect whether there are bubbles in the mixed liquid.

[0043] The function of the second sampling port 33 is to collect a liquid sample formed by mixing blood cells and plasma through the second sampling port 33 for detection and analysis.

[0044] A return pump 41 and a heater 42 are provided inside the reflux line 4. When supplementary fluid (plasma / albumin solution / plasma bag supplies, etc.) is input through the fluid infusion port 10, the return pump 41 is turned on to pump the supplementary fluid into the intravenous pot 31 through the fluid infusion port 10 and the reflux line 4.

[0045] The function of the warmer 42 is to raise the temperature of the plasma to the temperature of the human body 1 to prevent the patient from feeling uncomfortable when the plasma is returned to the human body 1 .

[0046] Furthermore, a separation valve is provided inside the reflux pipeline 4 , and the separation valve is located between the intravenous pot 31 and the warmer 42 .

[0047] A first reflux valve 401 and a second reflux valve 402 are further provided inside the reflux pipeline 4 , and different treatment modes can be switched through the first reflux valve 401 and the second reflux valve 402 .

[0048] Open the injection valve 711 and close the first discharge valve 601, so that the basic treatment unit is connected with the first additional unit, and DPMAS treatment, i.e. double plasma molecule adsorption blood purification, can be performed.

[0049] Open the first delivery valve 807, the first side output valve 721, the second side output valve 722, the third side output valve 723, and the second discharge valve 911, and close the second delivery valve 803, so that the basic treatment unit is connected with the first additional unit and the second additional unit, and DFPP treatment, i.e., double plasma exchange, can be performed.

[0050] Open the first circulation valve 901 and the second circulation valve 902, and close the second discharge valve 911 and the second side output valve 722, so that the basic treatment unit is connected with the first additional unit, the second additional unit, and the third additional unit, and a new adsorption treatment can be performed.

[0051] By opening and closing each valve, the treatment plan can be changed. A set of pipelines can realize the switching of multiple treatment modes at will, avoiding the current situation where two sets of pipelines are needed to complete complex modes, and avoiding the situation where the automatic pre-flushing program of the artificial liver blood purification machine cannot be used to complete the pre-flushing due to the splicing of pipelines. First, it reduces the use of consumables. Second, it avoids human intervention in manual pre-flushing and reduces the possibility of contamination. Third, it reduces the difficulty of installation and pre-flushing operations, which is conducive to improving operability, rapid homogeneous promotion, and improving treatment safety.

[0052] Applicable to multiple modes: In addition to being applicable to a variety of mature artificial liver treatment modes, the improved pipeline is also suitable for new adsorption therapy, complex mode therapy and the development of biological artificial liver therapy.

[0053] Replaceable venous pot 31 and pipeline: Due to the change of artificial liver blood purification treatment mode, the complexity increases, the treatment time is prolonged, and the treatment may even last for more than 8 hours. In the extracorporeal circulation pipeline 9, especially the incidence of thrombosis in the venous pot 31, it will also increase with time. It manifests as an increase in instrument pressure during treatment, and even blood coagulation blockage in the pipeline occurs and treatment cannot be performed. A connectable end design is used in the venous pipeline to break the conventional integrated pipeline form. Before the venous pot 31 thrombosis occurs and the pipeline coagulation occurs, the independent part of the pipeline assembly can be replaced, so as not to replace the first separator 5, the second separator 7 and the entire set of treatment pipelines due to blockage of the venous pipeline. Avoid unplanned machine removal and failure to achieve the expected treatment goals; avoid the consumption of coagulation substances in the patient's body, increase the risk of bleeding, and reduce economic losses.

[0054] The design of connectable end in the venous line breaks the conventional integrated line form, and the independent part of the line assembly can be replaced when venous pot 31 thrombosis occurs, so that the primary membrane, secondary membrane and the whole set of treatment lines do not need to be replaced due to the blockage of the venous line. In this way, it can reduce medical costs, reduce patient expenses, reduce blood loss and coagulation material consumption caused by line coagulation, and reduce the workload and time cost of operators to reinstall the line.

[0055] Convenient management: Liver failure patients are in critical condition and their conditions change rapidly, and they often need to temporarily change their treatment plans to carry out emergency treatment. There are many types of non-bioartificial liver treatments, and different treatment modes require different pipelines for a certain treatment. This will result in a large number and variety of pipelines being put into storage in the department. Since it is impossible to predict the frequency and amount of pipeline use, it is easy to have a large number of pipelines in storage, but the pipeline models are incomplete or even expired. In this case, on the one hand, the workload of managers is increased, and on the other hand, it may even affect patient treatment. The improved pipeline can be applied to multiple treatment modes with one set of pipelines, alleviating the pressure on nursing managers.

[0056] Example 2

[0057] like Figure 2 As shown, it is an improved multi-purpose pipeline for artificial liver blood purification during plasma exchange treatment. At this time, the first discharge valve 601, the first return valve 401, the second return valve 402, the rehydration valve 101, the first pump body 23, the second pump body 63 are opened, and the injection valve 711 and the third side output valve 723 are closed.

[0058] During the treatment process, the patient's blood enters the first separator 5 through the output pipeline 2 under the drive of the first pump body 23. The first separator 5 separates part of the plasma from the whole blood, and the plasma is discharged through the plasma pipeline 6 and the first discharge port 61 under the drive of the second pump body 63; the cell components separated by the first separator 5 enter the venous pot 31 through the first output tube 51, and at the same time, the fluid replenishment port 10 inputs the supplementary fluid (plasma / albumin solution / plasma bag supplies, etc.) into the second pump body 63. After the supplementary fluid is mixed with the blood cells, it returns to the human body 1 through the input pipeline 3.

[0059] In this process, the patient's blood samples can be collected for testing and analysis through the first sampling port 22 and the second sampling port 33 as needed. The warmer 42 raises the temperature of the plasma to the human body temperature, reducing the patient's discomfort when the plasma is returned to the human body 1.

[0060] The first fluid infusion port 21 can be used as a fluid infusion passage to infuse fluid to supplement the blood volume of the patient during treatment, and can be connected to the fluid to complete the blood return after the machine is removed.

[0061] A plurality of pressure detection ports are provided inside the output pipeline 2 , and the pressures at different positions inside the output pipeline 2 can be detected through different pressure detection ports.

[0062] The pressure inside the plasma jug 64 can be measured through the plasma pressure measuring port 641, thereby obtaining the internal pressure data of the plasma pipeline 6. At the same time, the internal pressure of the first separator 5 is detected through the separator pressure measuring port 52 located on the side wall of the first separator 5.

[0063] During the treatment, the plasma containing high concentration of bilirubin and toxic substances is discarded, and the patient's body is supplemented with infusion fluid (plasma / albumin solution / plasma bag supplies, etc.) through the fluid infusion port 10 to help the patient remove toxins. Example 3

[0064] like Figure 3 As shown, an improved multi-purpose tubing for artificial liver blood purification for dual plasma molecule adsorption blood purification treatment.

[0065] At this time, open the second reflux valve 402, the injection valve 711, the second delivery valve 803, the third delivery valve 804, the fourth delivery valve 805, the first pump body 23, and the second pump body 63, and close the first reflux valve 401, the first discharge valve 601, the liquid replenishment valve 101, the second side output valve 722, the third side output valve 723, the first delivery valve 807, and the return slurry pump 41.

[0066] During the treatment, the patient's blood enters the first separator 5 through the output pipeline 2 under the drive of the first pump body 23, and the first separator 5 separates part of the plasma from the whole blood. The separated plasma enters the plasma pot 64 through the plasma pipeline 6 under the drive of the second pump body 63, and the plasma inside the plasma pot 64 enters the second separator 7. The second separator 7 filters the plasma and injects it into the venous pot 31 through the relay pipeline 8 and the return pipeline 4. In this process, the plasma separated in the first separator 5 enters the adsorption device 95, and the bilirubin and toxic substances in the plasma are adsorbed in the adsorption device 95. The adsorbed plasma enters the interior of the venous pot 31 through the relay pipeline 8 and the return pipeline 4, and then mixes with the blood cells and returns to the patient's body through the input pipeline 3.

[0067] The blood cells separated by the first separator 5 enter the venous pot 31 through the first output tube 51 and are mixed with the adsorbed plasma. The mixed liquid returns to the patient's body through the input pipeline 3.

[0068] During the treatment process, the second separator 7 adsorbs bilirubin and toxic substances in the plasma to help the patient remove high bilirubin components and toxic substances in the blood.

[0069] Specifically, the second separator 7 is a novel adsorption device 95 .

[0070] Example 4

[0071] like Figure 4 Shown is a modified multi-purpose tubing for artificial liver blood purification for double plasma exchange therapy.

[0072] At this time, open the first return valve 401, the second return valve 402, the injection valve 711, the first delivery valve 807, the first side output valve 721, the second side output valve 722, the third side output valve 723, the second discharge valve 911, the rehydration valve 101, the injection valve 711, the first pump body 23, the second pump body 63, and the return slurry pump 41, and close the first discharge valve 601, the second delivery valve 803, the third delivery valve 804, and the fourth delivery valve 805.

[0073] During the treatment, the patient's blood enters the first separator 5 through the output pipeline 2 under the drive of the first pump body 23. The first separator 5 separates part of the plasma from the whole blood. The plasma enters the second separator 7 through the plasma pipeline 6. The separated plasma flows through the second separator 7 (plasma component separator) with a smaller pore size than the first separator 5. Small molecules in the plasma that are larger than the pore size of the plasma component separator membrane can flow through the membrane pores into the venous pot 31 and be re-infused into the body. The second separator 7 discharges the filtered plasma containing pathogenic substances with larger molecular weight through the second discharge port 91.

[0074] The blood cells separated by the first separator 5 enter the venous pot 31 through the first output tube 51. At the same time, the supplementary fluid (plasma / albumin solution / plasma bag supplies, etc.) passes through the venous pot 31 from the fluid replenishment port 10 to complete the mixing of the filtered plasma, supplementary fluid, and blood cells, and then returns to the human body 1 through the input pipeline 3.

[0075] During the treatment, the second separator 7 removes pathogenic substances (antibodies, antigens, lipoproteins, etc.) with large molecular weight in the plasma to improve the internal environment of the body. The intravenous pot 31 is replenished with a replenishing fluid equal to the discarded waste fluid through the replenishing port 10.

[0076] Preferably, the flow rate of the waste plasma discharged through the second discharge port 91 is equal to the flow rate of the plasma replenished to the intravenous pot 31 through the fluid replenishment port 10 .

[0077] Example 5

[0078] like Figure 5 Shown is an improved multi-purpose tubing for artificial liver blood purification for a new adsorption therapy.

[0079] At this time, open the first return valve 401, the second return valve 402, the injection valve 711, the first side output valve 721, the third side output valve 723, the second delivery valve 803, the third delivery valve 804, the rehydration valve 101, the injection valve 711, the first pump body 23, the second pump body 63, and the return slurry pump 41, and close the first discharge valve 601, the second side output valve 722, the fourth delivery valve 805, the second discharge valve 911, and the first delivery valve 807.

[0080] During the treatment process, the patient's blood enters the first separator 5 through the output pipeline 2 under the drive of the first pump body 23, and the first separator 5 separates part of the plasma from the whole blood. The plasma enters the second separator 7 through the plasma pipeline 6. When the adsorption device 95 is an adsorber, the second separator 7 is a plasma component separator. At this time, the intercepted macromolecular substances in the plasma that are larger than the pore size of the plasma component separator membrane pass through the circulation pipeline 9 and enter the adsorption device 95 for repeated adsorption treatment. The unintercepted plasma enters the input pipeline 3 through the relay pipeline 8 after the second separator 7. When the adsorption device 95 is a biological device / bioreactor containing cell components, the second separator 7 can be a plasma component separator or a cell filter. At this time, the second separator 7 can separate the plasma from the biological cells, playing a role in preventing the biological cell components from entering the body. A part of the plasma or the biological cells exchange substances through the hollow fiber or semipermeable membrane in the second separator 7. This part of the plasma passes through the circulation pipeline 9 and enters the biological device, and the biological materials therein can repeatedly enter the second separator 7 through the circulation pipeline 9. Another part of the plasma enters the input line 3 through the relay line 8.

[0081] The blood cells separated by the first separator 5 enter the venous pot 31 through the first output tube 51 to complete filtration / adsorption. The plasma and blood cells are mixed in the venous pot 31 and then return to the human body 1 through the input pipeline 3.

[0082] During the treatment process, the second separator 7 plays a role of separation or interception, separating the macromolecular toxic substances in the plasma and intercepting the cell components in the adsorption device 95 to prevent them from entering the human body 1.

[0083] In the description of this specification, the description with reference to the terms "embodiment", "some embodiments", "illustrative embodiments", "example", "specific example", "some examples", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0084] The embodiments described in this application are only some embodiments of the present invention, not all embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation methods. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

Claims

1. An improved multi-purpose pipeline for artificial liver blood purification, characterized in that: It includes: A basic treatment unit, comprising an output pipeline, an input pipeline, a first separator, a plasma pipeline and a fluid infusion port; one end of the first separator is connected to the output pipeline, and the other end is connected to the input pipeline; the side wall of the first separator is connected to the plasma pipeline; one end of the input pipeline is in communication with the fluid infusion port; a fluid infusion valve is provided on the fluid infusion port; and a first discharge port is provided at one end of the plasma pipeline away from the first separator; The first additional unit includes an injection tube, a second separator and a relay pipeline; one end of the second separator is connected to the plasma pipeline through the injection tube, and the other end is connected to the input pipeline through the relay pipeline; The second additional unit comprises a side output pipe and a first delivery pipe; one end of the side output pipe is connected to the second separator, and the other end is connected to the input pipeline; one end of the first delivery pipe is connected to the relay pipeline, and the other end is provided with a second discharge port; The third additional unit comprises a circulation pipeline; one end of the circulation pipeline is connected to the side output pipe, and the other end of the circulation pipeline is connected to the side wall of the second separator.

2. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: It also includes a reflux pipeline; one end of the reflux pipeline is connected to the input pipeline, and the other end is connected to the fluid infusion port.

3. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: The side output pipe is further provided with a second side output valve, a third side output valve and a four-way joint; the four-way joint is connected in series inside the side output pipe and is located between the second side output valve and the third side output valve; the other two interfaces of the four-way joint are connected in series inside the relay pipeline; the first side output valve is located between the second side output valve and the second separator.

4. The improved multi-purpose pipeline for artificial liver blood purification according to claim 3, characterized in that: The connection point between the circulation pipeline and the side output pipe is between the first delivery valve and the second delivery valve.

5. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: The side output pipe is connected to the input pipeline through a return slurry pump.

6. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: The relay pipeline includes a relay pipe body, a second delivery pipe and a third delivery pipe; the relay pipe body, the second delivery pipe and the third delivery pipe are connected by a second three-way joint; one end of the second delivery pipe away from the relay pipe body is connected to the side output pipe; one end of the third delivery pipe is connected to the side output pipe, and the other end is connected to the input pipeline; a second delivery valve is provided inside the second delivery pipe; a fourth delivery valve is provided inside the third delivery pipe.

7. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: A first pump body is arranged inside the output pipeline.

8. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: A second pump body is arranged inside the plasma pipeline.

9. The improved multi-purpose pipeline for artificial liver blood purification according to claim 1, characterized in that: A third pump body is arranged inside the circulation pipeline.

10. An improved multi-purpose pipeline for artificial liver blood purification according to any one of claims 1 to 9, characterized in that: An adsorption device is arranged inside the circulation pipeline.

Images