Filling equipment for preventing sitafloxacin injection from being degraded

Abstract

The invention relates to the technical field of injection filling, and particularly discloses filling equipment for preventing sitafloxacin injection from being degraded, the filling equipment comprises an equipment base and a filling container, the filling container is located at the top of the equipment base, the upper surface of the equipment base is fixedly connected with a supporting seat, and the upper surface of the supporting seat is fixedly connected with a supporting platform; the upper surface of the supporting platform is fixedly connected with a discharging barrel, the upper surface of the discharging barrel is fixedly connected with a motor, and the inner side of the supporting base is provided with a feeding assembly used for achieving stable circulating feeding of the filling containers; according to the cisastasacin injection filling device, cisastasacin injection can be filled into the filling container in a sealed mode through the filling pipe, contact between the injection and the external environment is reduced, external microorganisms, dust, impurities and the like are effectively prevented from entering the injection, the pollution risk is reduced, meanwhile, the oxidation speed, the degradation speed and the microorganism breeding speed are reduced, and therefore the purity and quality of the injection are guaranteed; and the storage life of the injection is prolonged.

Description

Technical Field

[0001] The invention relates to the technical field of injection filling, and in particular to a filling device for preventing sitafloxacin injection from degradation. Background Art

[0002] Injections refer to sterile solutions made of drugs for injection into the body, as well as sterile powders or concentrated solutions for preparation into solutions or suspensions before clinical use. The production of injections is usually carried out in clean rooms or clean areas to reduce the risk of microbial contamination, and the ingredients, mixing, filtering and filling are carried out in strict accordance with the procedures, and quality control and inspection are carried out.

[0003] During the filling process of the existing sitafloxacin injection, the container to be filled needs to be cleaned, disinfected and dried to ensure the sterility of the container, and then the drug solution is accurately filled into the container through the filling equipment to ensure that the amount of drug solution in each container is consistent, and the filled container is sealed, usually with a bottle cap, a stopper or a sealing device. There is a gap between the traditional filling equipment and the filling container. The air in the gap will not only contaminate the filling port part of the filling container, but also come into contact with it during the filling of sitafloxacin, causing the degradation of sitafloxacin and affecting the overall filling quality and safety.

[0004] Therefore, it is necessary to provide a filling device for preventing sitafloxacin injection from degradation, aiming to solve the above problems. Summary of the invention

[0005] The main purpose of the present invention is to provide a filling device for preventing sitafloxacin injection from degradation, which can effectively solve the problems in the background technology.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] A filling device for preventing sitafloxacin injection from degradation comprises a device base and a filling container, wherein the filling container is located on the top of the device base, a support seat is fixedly connected to the upper surface of the device base, a support platform is fixedly connected to the upper surface of the support seat, a lower material barrel is fixedly connected to the upper surface of the support platform, a motor is fixedly connected to the upper surface of the lower material barrel, a feeding assembly for realizing stable cyclic feeding of the filling container is arranged on the inner side of the support seat, and a filling assembly for realizing sealed filling of the filling container is arranged at the bottom of the lower material barrel;

[0008] The filling assembly includes a fixed seat fixedly connected to the bottom of the discharge barrel, a movable plate is slidably connected to the inner side of the support platform, a movable tube is slidably connected to the inner side of the fixed seat, a canning tube is slidably connected to the inner side of the movable tube, a connecting block is symmetrically fixedly connected between the movable plate and the canning tube, the connecting blocks are all penetrated and slidably connected to the inside of the movable tube, a spring 1 is fixedly connected between the connecting block and the movable tube, a fixed sleeve is fixedly connected to the top of the filling container, a movable sleeve is slidably connected to the inside of the fixed sleeve, a sealing plate is slidably connected to the inside of the movable sleeve, and a spring 3 is symmetrically fixedly connected between the movable sleeve and the fixed sleeve;

[0009] The loading assembly includes a loading plate rotatably connected to the inside of a support seat, the upper surface of the loading plate is evenly provided with container grooves, the filling container is slidably connected to the inner side of the container grooves, a loading trough body is fixedly connected to the inside of the equipment base, the lower surface of the support seat is provided with a loading trough that penetrates into one of the container grooves, and the loading trough body is located inside the equipment base at one end directly below the loading trough.

[0010] As a further improvement of the above scheme, the loading assembly also includes a driving shaft and a stirring shaft rotatably connected to the unloading barrel, the stirring shaft is fixedly connected to the motor output shaft, the stirring shaft and the top of the driving shaft are fixedly connected to a fixed gear, the two fixed gears are meshed with each other, the driving shaft and the outer sides of the stirring shaft are fixedly connected to stirring rods, the stirring rods on the driving shaft and the stirring rods on the stirring shaft are cross-distributed, the bottom end of the driving shaft is fixedly connected to a reciprocating screw, the movable plate is slidably connected to the outer side of the reciprocating screw, the bottom end of the reciprocating screw is fixedly connected to a fixed shaft, the outer side of the fixed shaft is fixedly connected to an incomplete gear, the inside of the loading tray is fixedly connected to a gear ring, and a driven gear is rotatably connected to the inner wall of the support seat, the driven gear and the gear ring are meshed with each other, and the driven gear and the incomplete gear gear part are meshed with each other.

[0011] As a further improvement of the above solution, the filling assembly also includes a fixing rod fixedly connected to the bottom end of the sealing plate, a stopper is fixedly connected to the bottom end of the fixing rod, and a second spring is fixedly connected between the stopper and the fixing sleeve.

[0012] As a further improvement of the above solution, a connecting sleeve is fixedly connected to the top end of the filling container, and the inner wall of the connecting sleeve is in contact with the outer wall of the movable sleeve.

[0013] As a further improvement of the above solution, a circular hole penetrating into the interior of the canning tube is provided at the bottom thereof, and through holes matching the circular hole are provided on the outer walls of the fixed sleeve and the movable sleeve.

[0014] As a further improvement of the above solution, a sliding groove running through the interior of the movable tube is provided at the bottom of the movable tube, and the connecting block is slidably connected to the interior of the sliding groove.

[0015] As a further improvement of the above solution, a cleaning block is fixedly connected to the interior of the support platform, and the lower surface of the cleaning block and the upper surface of the loading tray are located on the same horizontal plane.

[0016] As a further improvement of the above solution, a packaging seat is fixedly connected to the interior of the support platform, and an arc-shaped packaging groove is formed on the lower surface of the packaging seat.

[0017] The filling method for preventing the degradation of sitafloxacin injection comprises the following steps:

[0018] Step 1: Ensure that the filling equipment is clean and set up according to the production process requirements, check the quality and light-proof performance of the packaging materials, ensure that the temperature and humidity of the filling environment meet the requirements, check whether the filling equipment is operating normally, and clean each part of the equipment by ultrasonic cleaning or steam sterilization to ensure that there are no impurities and contaminants;

[0019] Step 2: Accurately weigh and prepare the sitafloxacin injection solution according to the formulation requirements, and control the pH value, osmotic pressure and other parameters of the solution to maintain its stability. According to the properties of the solution, select an appropriate mixing method to ensure that the API and excipients are fully mixed;

[0020] Step 3: According to the size of the injection container and the filling requirements, adjust the filling speed and filling volume parameters of the filling equipment, install the clean filling needle on the filling equipment, and ensure that it is well sealed, place the injection container on the filling position of the filling equipment, ensure that the container is stable and aligned with the filling needle, use light-proof filling equipment or take light-proof measures during the filling process, shorten the filling time as much as possible, and reduce the contact between the drug solution and light;

[0021] Step 4: Seal the filled syringe to ensure that the seal is intact and use light-proof packaging materials to further prevent the influence of light on the injection;

[0022] Step 5: Perform quality control steps such as appearance inspection, liquid level inspection and leakage inspection, and conduct stability inspection on the filled product to ensure that it meets quality standards.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] 1. The cisatacin injection can be sealed and poured into the filling container through the canning tube, which reduces the contact between the injection and the external environment, effectively prevents external microorganisms, dust, impurities, etc. from entering the injection, reduces the risk of pollution, and reduces the rate of oxidation, degradation and microbial growth, thereby ensuring the purity and quality of the injection and extending the shelf life of the injection; the loading tray can realize stable cyclic loading of the filling container, so as to continuously realize the filling of citafloxacin in the filling container, reduce the interruption and pause of loading, and ensure the uniform mixing and stable supply of the injection, avoid the quality difference between batches, thereby improving the production efficiency, as well as the consistency and stability of the product.

[0025] 2. The cleaning block can be used to clean the top of the filling container, which can not only remove residual substances, dirt and microorganisms inside the equipment, prevent contamination of the injection solution, improve the quality and purity of the product, but also prevent the residual substances of the previous batch or product from causing cross contamination to the current batch or product.

[0026] 3. The fixed packaging of the filling container is achieved by squeezing the connecting sleeve through the packaging seat, providing a stable packaging environment, reducing the impact of external factors on the injection solution, making the injection solution more stable during transportation and storage, reducing the risk of leakage and damage, and ensuring the quality and stability of the product. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0028] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0029] Figure 2 It is a schematic diagram of the overall cross-sectional structure of the present invention;

[0030] Figure 3 For the present invention Figure 2 Schematic diagram of the structure at A in the middle;

[0031] Figure 4 It is a schematic diagram of the cross-sectional structure of the material discharge barrel of the present invention;

[0032] Figure 5 It is a schematic diagram of the cross-sectional structure of the support platform of the present invention;

[0033] Figure 6 It is a schematic diagram of the cross-sectional structure of the feed chute body of the present invention;

[0034] Figure 7 It is a schematic diagram of the support base structure of the present invention;

[0035] Figure 8 It is a schematic diagram of the structure of the canned container of the present invention.

[0036] In the figure: 1. Equipment base; 2. Support base; 3. Support platform; 4. Unloading bucket; 5. Motor;

[0037] The feeding assembly includes: 601, feeding plate; 602, feeding trough body; 603, gear ring; 604, container trough; 605, driving shaft; 606, fixed gear; 607, stirring shaft; 608, stirring rod; 609, reciprocating screw rod; 610, fixed shaft; 611, incomplete gear; 612, driven gear;

[0038] The filling assembly includes: 701, a fixed seat; 702, a movable plate; 703, a movable tube; 704, a canning tube; 705, a packaging seat; 706, a spring 1; 707, a fixed sleeve; 708, a connecting sleeve; 709, a fixed rod; 710, a stopper; 711, a spring 2; 712, a spring 3; 713, a connecting block; 714, a movable sleeve; 715, a cleaning block; 716, a sealing plate;

[0039] 8. Filling container. DETAILED DESCRIPTION

[0040] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0041] See also Figures 1 to 8 As shown, one embodiment of the present invention provides:

[0042] A filling device for preventing sitafloxacin injection from degradation comprises a device base 1 and a filling container 8, wherein the filling container 8 is located on the top of the device base 1, a support seat 2 is fixedly connected to the upper surface of the device base 1, a support platform 3 is fixedly connected to the upper surface of the support seat 2, a feed barrel 4 is fixedly connected to the upper surface of the support platform 3, a motor 5 is fixedly connected to the upper surface of the feed barrel 4, a feeding assembly for realizing stable cyclic feeding of the filling container 8 is arranged on the inner side of the support seat 2, and a filling assembly for realizing sealed filling of the filling container 8 is arranged at the bottom of the feed barrel 4;

[0043] The filling assembly includes a fixed seat 701 fixedly connected to the bottom of the discharge barrel 4, a movable plate 702 is slidably connected to the inner side of the support platform 3, a movable tube 703 is slidably connected to the inner side of the fixed seat 701, a canning tube 704 is slidably connected to the inner side of the movable tube 703, a connecting block 713 is symmetrically fixedly connected between the movable plate 702 and the canning tube 704, the connecting blocks 713 are all penetrated and slidably connected to the inside of the movable tube 703, a spring 1 706 is fixedly connected between the connecting block 713 and the movable tube 703, a fixed sleeve 707 is fixedly connected to the top of the filling container 8, a movable sleeve 714 is slidably connected to the inside of the fixed sleeve 707, a sealing plate 716 is slidably connected to the inside of the movable sleeve 714, and a spring 3 712 is symmetrically fixedly connected between the movable sleeve 714 and the fixed sleeve 707;

[0044] The loading assembly includes a loading plate 601 rotatably connected to the inside of the support seat 2, and container grooves 604 are evenly opened on the upper surface of the loading plate 601. The filling container 8 is slidably connected to the inner side of the container groove 604. A feeding trough body 602 is fixedly connected to the inside of the equipment base 1, and a feeding trough is opened on the lower surface of the support seat 2 and penetrates into one of the container grooves 604. The feeding trough body 602 is located in the equipment base 1 at one end directly below the feeding trough.

[0045] The support seat 2 can support the loading assembly to ensure that the loading assembly can load the filling container 8 stably. The lowering barrel 4 can provide the injection solution of sitafloxacin for mixing. The support platform 3 can support the lowering barrel 4 stably and provide installation space for the movable plate 702, the packaging seat 705 and the cleaning block 715. The motor 5 can provide the power for loading and filling of the device. The movable tube 703 and the canning tube 704 in the fixed seat 701 can move up and down to realize cyclic filling and ensure the sealing during the filling process. The connection between the canning tube 704 and the movable plate 702 is realized by the connecting block 713. The movable plate 702 is connected to each other so that the canning tube 704 can be driven by the movable plate 702 to move downward to realize the filling of sitafloxacin. The movable tube 703 can be driven to elastically return between the fixed seat 701 and the canning tube 704 through the spring 1 706. The movable sleeve 714 can be reset in the filling container 8 through the spring 3 712. The sealing plate 716 can realize the sealing of the top of the filling container 8. The unloading chute body 602 can realize the unloading of the filling container 8 after filling. The container trough 604 can realize the placement of the filling container 8, so that the filling container 8 can realize intermittent loading with the intermittent rotation of the loading plate 601.

[0046] Furthermore, the feeding assembly also includes a driving shaft 605 and a stirring shaft 607 which are rotatably connected to the lowering barrel 4. The stirring shaft 607 is fixedly connected to the output shaft of the motor 5. The stirring shaft 607 and the top of the driving shaft 605 are fixedly connected to a fixed gear 606. The two fixed gears 606 are meshed with each other. The driving shaft 605 and the outer side of the stirring shaft 607 are fixedly connected to stirring rods 608. The stirring rods 608 on the driving shaft 605 and the stirring rods 608 on the stirring shaft 607 are cross-distributed. The bottom end of 605 is fixedly connected to a reciprocating screw 609, a movable plate 702 is slidably connected to the outside of the reciprocating screw 609, a fixed shaft 610 is fixedly connected to the bottom end of the reciprocating screw 609, an incomplete gear 611 is fixedly connected to the outside of the fixed shaft 610, a gear ring 603 is fixedly connected to the inside of the loading tray 601, a driven gear 612 is rotatably connected to the inner wall of the support seat 2, the driven gear 612 and the gear ring 603 are meshed with each other, and the driven gear 612 and the gear part of the incomplete gear 611 are meshed with each other.

[0047] The rotation of the driving shaft 605 and the fixed gear 606 can drive the stirring rod 608 to achieve mixing and stirring of the injection liquid in the lower barrel 4. The driving shaft 605 can drive the reciprocating screw 609 and the fixed shaft 610 to rotate synchronously. The reciprocating screw 609 drives the movable plate 702 to slide up and down under the action of the outer bidirectional spiral groove. The rotation of the loading tray 601 can be achieved through the engagement of the gear part of the incomplete gear 611 with the driven gear 612.

[0048] Furthermore, the filling assembly also includes a fixing rod 709 fixedly connected to the bottom end of the sealing plate 716 , a stopper 710 is fixedly connected to the bottom end of the fixing rod 709 , and a spring 2 711 is fixedly connected between the stopper 710 and the fixing sleeve 707 .

[0049] The second spring 711 and the fixing rod 709 enable the second spring 711 to push the sealing plate 716 to reset under the action of elastic reset rebound, and the stopper 710 can realize the storage and sealing of the second spring 711 after reset and retraction.

[0050] Furthermore, a connecting sleeve 708 is fixedly connected to the top of the filling container 8 , and the inner wall of the connecting sleeve 708 fits with the outer wall of the movable sleeve 714 .

[0051] The cleaning block 715 can squeeze the connecting sleeve 708 to deform and penetrate the movable sleeve 714 to fix the sealing plate 716 in the filling container 8, thereby achieving fixed packaging of the filling container 8.

[0052] Furthermore, a circular hole penetrating into the interior of the canning tube 704 is provided at the bottom thereof, and through holes matching the circular hole are provided on the outer walls of the fixed sleeve 707 and the movable sleeve 714 .

[0053] The injection liquid can be filled by connecting the circular hole and the through hole. When the filling tube 704, the fixed sleeve 707 and the movable sleeve 714 are reset, the injection liquid cannot flow out from the top of the filling container 8.

[0054] Furthermore, a sliding groove running through the interior of the movable tube 703 is provided at the bottom thereof, and the connecting block 713 is slidably connected to the interior of the sliding groove.

[0055] The movable plate 702 can drive the canning tube 704 to move up and down through the slide groove, and the spring 1 706 drives the movable tube 703 to push the movable sleeve 714 to move to a specified position.

[0056] Furthermore, a cleaning block 715 is fixedly connected to the interior of the supporting platform 3 , and the lower surface of the cleaning block 715 and the upper surface of the loading tray 601 are located on the same horizontal plane.

[0057] The cleaning block 715 attached to the upper surface of the loading tray 601 can be used to clean the filling container 8, the movable sleeve 714 and the upper surface of the sealing plate 716, remove residual substances, dirt and microorganisms inside the equipment, prevent contamination of the injection solution, and improve the quality and purity of the product.

[0058] Furthermore, a packaging seat 705 is fixedly connected to the interior of the supporting platform 3 , and an arc-shaped packaging groove is formed on the lower surface of the packaging seat 705 .

[0059] The connecting sleeve 708 can be squeezed through the arc-shaped packaging groove in the packaging seat 705, so that the connecting sleeve 708 is deformed and penetrates the movable sleeve 714 to fix the sealing plate 716 in the filling container 8, so as to further ensure the stability of the packaging of the filling container 8.

[0060] The present invention provides another embodiment:

[0061] The filling method for preventing the degradation of sitafloxacin injection comprises the following steps:

[0062] Step 1: Ensure that the filling equipment is clean and set up according to the production process requirements, check the quality and light-proof performance of the packaging materials, ensure that the temperature and humidity of the filling environment meet the requirements, check whether the filling equipment is operating normally, and clean each part of the equipment by ultrasonic cleaning or steam sterilization to ensure that there are no impurities and contaminants;

[0063] Step 2: Accurately weigh and prepare the sitafloxacin injection solution according to the formulation requirements, and control the pH value, osmotic pressure and other parameters of the solution to maintain its stability. According to the properties of the solution, select an appropriate mixing method to ensure that the API and excipients are fully mixed;

[0064] Step 3: According to the size of the injection container and the filling requirements, adjust the filling speed and filling volume parameters of the filling equipment, install the clean filling needle on the filling equipment, and ensure that it is well sealed, place the injection container on the filling position of the filling equipment, ensure that the container is stable and aligned with the filling needle, use light-proof filling equipment or take light-proof measures during the filling process, shorten the filling time as much as possible, and reduce the contact between the drug solution and light;

[0065] Step 4: Seal the filled syringe to ensure that the seal is intact and use light-proof packaging materials to further prevent the influence of light on the injection;

[0066] Step 5: Perform quality control steps such as appearance inspection, liquid level inspection and leakage inspection, and conduct stability inspection on the filled product to ensure that it meets quality standards.

[0067] In combination with the above preferred embodiments, the working principle of the present invention is as follows:

[0068] The initial state is as follows: the connecting block 713 is fitted with the inner wall of the top of the movable tube 703 under the action of the elastic stretching force of spring one 706; the circular hole at the bottom of the canning tube 704 is located on the inner side of the bottom of the movable tube 703 to facilitate sealing of the bottom of the canning tube 704; the movable plate 702 moves to the inner side of the top of the support platform 3 under the action of the reciprocating screw 609; the sealing plate 716 moves to the inner side of the top of the movable sleeve 714 under the action of the elastic rebound force of spring two 711; the sealing plate 716 moves to the top of the filling container 8 under the action of the elastic stretching force of spring three 712 to achieve misalignment of the through hole and the circular hole to facilitate sealing of the top of the filling container 8 to prevent the entry of impurities and air.

[0069] The working status is as follows:

[0070] Loading steps:

[0071] First, the operator needs to place the filling container 8 in the container slot 604 on the loading tray 601, and then start the motor 5 so that the output shaft of the motor 5 drives the stirring shaft 607 to rotate synchronously. Since the fixed gear 606 on the stirring shaft 607 is meshed with the fixed gear 606 on the driving shaft 605, the rotation of the stirring shaft 607 can drive the driving shaft 605 to rotate through the two meshing fixed gears 606. The rotating driving shaft 605 can not only drive the reciprocating screw 609 to rotate synchronously, but the driving shaft 605 can also cooperate with the stirring shaft 607 to drive several stirring rods 608 in the unloading barrel 4 to rotate synchronously to achieve uniform mixing of the sitafloxacin injection in the unloading barrel 4, so as to continuously realize the filling of sitafloxacin in the filling container, reduce the interruption and pause of loading, ensure the uniform mixing and stable supply of the injection, avoid the quality difference between batches, thereby improving the production efficiency, as well as the consistency and stability of the product;

[0072] At the same time, the rotating reciprocating screw 609 not only drives the fixed shaft 610 to rotate, but also drives the movable plate 702 to move up and down because the bidirectional spiral groove on the reciprocating screw 609 is slidably connected with the protrusion in the movable plate 702, and the reciprocating screw 609 can also drive the movable plate 702 to move reciprocatingly up and down, and the fixed shaft 610 drives the incomplete gear 611 to rotate. When the gear part of the incomplete gear 611 is meshed with the driven gear 612, the incomplete gear 611 can push the driven gear 612 to rotate through the latch teeth, and the rotating driven gear 612 drives the gear ring 603 meshed with it to rotate synchronously, and the rotating gear ring 603 drives the loading tray 601 to rotate stably in the support seat 2, so as to drive the filling container 8 to move toward the bottom of the support platform 3 through the container groove 604, and when the gear part of the incomplete gear 611 is disengaged from the driven gear 612, the loading tray 601 drives the filling container 8 to stop rotating, so that the device can fill the filling container 8;

[0073] Filling steps:

[0074] The movable plate 702 that realizes reciprocating movement up and down driven by the reciprocating screw rod 609 drives the connecting block 713 to move synchronously. In the process that the movable plate 702 drives the connecting block 713 to move downward, the movable plate 702 can not only drive the canned tube 704 to move downward synchronously, but also drive the movable tube 703 to move downward synchronously through the spring 1 706. When the canned tube 704 is in contact with the upper surface of the sealing plate 716 and the movable tube 703 is in contact with the upper surface of the movable sleeve 714, the continued downward movement of the movable plate 702 will push the movable sleeve 714 to move downward through the movable tube 703 and compress the spring 3 712. When the movable tube 703 moves to the top of the connecting sleeve 708, the connecting block 713 continues to move downward. The movement can only realize the compression of the spring 1 706 inside the movable tube 703, and cannot continue to drive the movable tube 703 to move downward, and the through hole on the movable sleeve 714 is aligned with the through hole on the fixed sleeve 707. At the same time, the connecting block 713 that continues to move drives the canning tube 704 to move downward to squeeze the sealing plate 716, so that the sealing plate 716 moves downward and realizes the stretching of the spring 2 711 through the fixed rod 709 and the stopper 710. When the sealing plate 716 moves to the specified position, the circular hole on the canning tube 704 is connected with the through holes on the movable sleeve 714 and the fixed sleeve 707. At this time, the injection liquid in the supporting platform 3 can flow into the filling container 8 along the canning tube 704 to realize filling.

[0075] During the stable loading process of the filling container 8 driven by the loading tray 601, the filling container 8 will first pass under the cleaning block 715, so that the spring 2 711 and the sealing plate 716 on the filling container 8 can be cleaned by the cleaning block 715 to remove residual substances, dirt and microorganisms, prevent contamination of the injection liquid, and improve the quality and purity of the product. When the filling container 8 continues to move to under the movable plate 702, the intermittent loading loading tray 601 just stops. At this time, the reciprocating screw 609 that continues to rotate will drive the movable plate 702 to move downward and communicate with the filling container 8, so that the injection liquid enters the filling container 8 for filling. When the filling is completed, the reciprocating screw 609 starts to drive the movable plate 702 to move upward, and the gear part of the incomplete gear 611 also starts to mesh with the driven gear 612, and the meshing with each other The incomplete gear 611 and the driven gear 612 begin to drive the filling container 8 to continue moving and pass through the cleaning block 715, and then squeeze the connecting sleeve 708 under the action of the arc-shaped packaging groove of the cleaning block 715, so that the connecting sleeve 708 is deformed to pass through the through hole on the movable sleeve 714, and the sealing plate 716 is fixed in the movable sleeve 714, so as to complete the fixed packaging. Finally, the intermittently rotating loading plate 601 drives the filling container 8 to pass through the unloading trough on the support seat 2, falls from the unloading trough and unloads along the unloading trough body 602 after filling and packaging, reducing the contact between the injection liquid and the external environment, effectively preventing external microorganisms, dust, impurities, etc. from entering the injection liquid, reducing the risk of pollution, and reducing the rate of oxidation, degradation and microbial growth, thereby ensuring the purity and quality of the injection liquid and extending the shelf life of the injection liquid.

[0076] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "including one..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0077] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A filling device for preventing sitafloxacin injection from degradation, comprising a device base (1) and a filling container (8), wherein the filling container (8) is located on the top of the device base (1), and is characterized in that: The upper surface of the equipment base (1) is fixedly connected to a support seat (2), the upper surface of the support seat (2) is fixedly connected to a support platform (3), the upper surface of the support platform (3) is fixedly connected to a discharge barrel (4), the upper surface of the discharge barrel (4) is fixedly connected to a motor (5), the inner side of the support seat (2) is provided with a feeding assembly for realizing stable circulation feeding of the filling container (8), and the bottom of the discharge barrel (4) is provided with a filling assembly for realizing sealed filling of the filling container (8); The filling assembly comprises a fixed seat (701) fixedly connected to the bottom of the discharge barrel (4), a movable plate (702) is slidably connected to the inner side of the support platform (3), a movable tube (703) is slidably connected to the inner side of the fixed seat (701), a canning tube (704) is slidably connected to the inner side of the movable tube (703), a connecting block (713) is symmetrically fixedly connected between the movable plate (702) and the canning tube (704), and the connecting block (713) is penetrated and slidably connected to the inner side of the supporting platform (3). Connected to the inside of the movable tube (703), a spring one (706) is fixedly connected between the connecting block (713) and the movable tube (703), a fixed sleeve (707) is fixedly connected to the top of the filling container (8), a movable sleeve (714) is slidably connected to the inside of the fixed sleeve (707), a sealing plate (716) is slidably connected to the inside of the movable sleeve (714), and a spring three (712) is symmetrically fixedly connected between the movable sleeve (714) and the fixed sleeve (707); The loading assembly includes a loading plate (601) rotatably connected to the inside of the support seat (2), the upper surface of the loading plate (601) is evenly provided with container grooves (604), the filling container (8) is slidably connected to the inner side of the container grooves (604), the inside of the equipment base (1) is fixedly connected with a feeding trough body (602), the lower surface of the support seat (2) is provided with a feeding trough that penetrates into one of the container grooves (604), and the feeding trough body (602) is located in the equipment base (1) with one end directly below the feeding trough.

2. A filling device for preventing sitafloxacin injection from degradation according to claim 1, characterized in that: The feeding assembly further comprises a driving shaft (605) and a stirring shaft (607) rotatably connected to the feeding barrel (4); the stirring shaft (607) is fixedly connected to the output shaft of the motor (5); a fixed gear (606) is fixedly connected to the top of the stirring shaft (607) and the driving shaft (605); the two fixed gears (606) are meshed with each other; stirring rods (608) are fixedly connected to the outer sides of the driving shaft (605) and the stirring shaft (607); the stirring rods (608) on the driving shaft (605) and the stirring rods (608) on the stirring shaft (607) are cross-distributed; the driving shaft (60 5), the bottom end of the reciprocating screw (609) is fixedly connected, the movable plate (702) is slidably connected to the outer side of the reciprocating screw (609), the bottom end of the reciprocating screw (609) is fixedly connected to a fixed shaft (610), the outer side of the fixed shaft (610) is fixedly connected to an incomplete gear (611), the inside of the loading plate (601) is fixedly connected to a gear ring (603), and a driven gear (612) is rotatably connected to the inner wall of the support seat (2), the driven gear (612) and the gear ring (603) are meshed with each other, and the driven gear (612) and the gear part of the incomplete gear (611) are meshed with each other.

3. A filling device for preventing sitafloxacin injection from degradation according to claim 2, characterized in that: The filling assembly also includes a fixing rod (709) fixedly connected to the bottom end of the sealing plate (716), a stopper (710) fixedly connected to the bottom end of the fixing rod (709), and a second spring (711) fixedly connected between the stopper (710) and the fixing sleeve (707).

4. A filling device for preventing sitafloxacin injection from degradation according to claim 2, characterized in that: A connecting sleeve (708) is fixedly connected to the top end of the filling container (8), and the inner wall of the connecting sleeve (708) is in contact with the outer wall of the movable sleeve (714).

5. The filling equipment for preventing sitafloxacin injection from degradation according to claim 2, characterized in that: The bottom of the canning tube (704) is provided with a circular hole penetrating the inside thereof, and the outer walls of the fixed sleeve (707) and the movable sleeve (714) are both provided with through holes matching the circular hole.

6. A filling device for preventing sitafloxacin injection from degradation according to claim 2, characterized in that: The bottom of the movable tube (703) is provided with a sliding groove running through the inside thereof, and the connecting block (713) is slidably connected to the inside of the sliding groove.

7. The filling equipment for preventing sitafloxacin injection from degradation according to claim 3, characterized in that: A cleaning block (715) is fixedly connected to the interior of the support platform (3), and the lower surface of the cleaning block (715) and the upper surface of the loading tray (601) are located on the same horizontal plane.

8. The filling equipment for preventing sitafloxacin injection from degradation according to claim 3, characterized in that: A packaging seat (705) is fixedly connected to the interior of the support platform (3), and an arc-shaped packaging groove is provided on the lower surface of the packaging seat (705).

9. A filling method for preventing sitafloxacin injection from being degraded, the method being based on the filling device for preventing sitafloxacin injection from being degraded according to any one of claims 1 to 8, characterized in that: The following steps are involved: Step 1: Ensure that the filling equipment is clean and set up according to the production process requirements, check the quality and light-proof performance of the packaging materials, ensure that the temperature and humidity of the filling environment meet the requirements, check whether the filling equipment is operating normally, and clean each part of the equipment by ultrasonic cleaning or steam sterilization to ensure that there are no impurities and contaminants; Step 2: Accurately weigh and prepare the sitafloxacin injection solution according to the formulation requirements, and control the pH value, osmotic pressure and other parameters of the solution to maintain its stability. According to the properties of the solution, select an appropriate mixing method to ensure that the API and excipients are fully mixed; Step 3: According to the size of the injection container and the filling requirements, adjust the filling speed and filling volume parameters of the filling equipment, install the clean filling needle on the filling equipment, and ensure that it is well sealed, place the injection container on the filling position of the filling equipment, ensure that the container is stable and aligned with the filling needle, use light-proof filling equipment or take light-proof measures during the filling process, shorten the filling time as much as possible, and reduce the contact between the drug solution and light; Step 4: Seal the filled syringe to ensure that the seal is intact and use light-proof packaging materials to further prevent the influence of light on the injection; Step 5: Perform quality control steps such as appearance inspection, liquid level inspection and leakage inspection, and conduct stability inspection on the filled product to ensure that it meets quality standards.

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