Intelligent auxiliary saliva collection device for detecting infectious viruses in saliva

Abstract

The invention belongs to the technical field of saliva collection, and discloses an intelligent auxiliary saliva collection device for detecting infectious viruses in saliva. The intelligent auxiliary saliva collection device for detecting infectious viruses in saliva comprises a collection module, an antifouling module, a sample storage module, a processing module, an operation module, a data recording and tracking module, a sample transfer module and a detection processing module. Through accurate control of the sample collection amount, anti-pollution design, a preservation solution separation module and simple and convenient operation functions, the saliva sample collection precision, safety and user experience are remarkably improved, the stability and integrity of the collected sample in the detection process are ensured, and the saliva sample collection device is particularly suitable for detection and large-scale screening of infectious viruses.

Description

Technical Field

[0001] The present invention belongs to the technical field of saliva collection, and in particular relates to an intelligent auxiliary saliva collection device for detecting infectious viruses in saliva. Background Art

[0002] At present, the common collection method for detecting infectious viruses in saliva is usually to directly collect saliva samples from subjects and then send them to the laboratory for virus testing. This type of method generally relies on simple containers or collection tubes, such as cotton swabs, funnels and other collection devices. However, these traditional methods have problems such as difficult to control sample volume, high risk of sample contamination, and inability to ensure sufficient virus concentration. In addition, during the collection process, improper operation of the subjects can easily lead to insufficient quality of the collected samples, affecting the accuracy of the test results.

[0003] Through the above analysis, the problems and defects of the prior art are as follows:

[0004] (1) Sample volume control problem: Traditional collection methods make it difficult to accurately control the amount of saliva collected, resulting in too much or too little sample, which in turn affects the accuracy of virus detection.

[0005] (2) Sample contamination problem: During the process of collecting and transferring samples, samples are easily exposed to the air, which increases the risk of external contamination and affects the test results.

[0006] (3) Sample preservation problem: Existing collection devices lack the ability to quickly preserve or process saliva samples, resulting in virus inactivation or degradation of sample quality, affecting subsequent detection accuracy.

[0007] (4) Operational convenience issues: Traditional saliva collection devices often require the subjects to be familiar with the collection process. If the operation is not standardized, it is easy to cause the sample quality to substandard, increasing the risk of test failure. Summary of the invention

[0008] In view of the problems existing in the prior art, the present invention provides an intelligent auxiliary saliva collection device for detecting infectious viruses in saliva.

[0009] The present invention is implemented as follows: an intelligent auxiliary saliva collection device for detecting infectious viruses in saliva comprises:

[0010] Collection module, anti-fouling module, sample preservation module, processing module, operation module, data recording and tracking module, sample transfer module, detection and processing module;

[0011] The collection module is connected to the anti-fouling module and is used for collecting a collection device having an adjustable graduated tube inside, with different graduation lines marked inside the tube to indicate the amount of saliva to be collected;

[0012] The anti-fouling module is connected to the collection module and the sample storage module. The nozzle of the collection device is designed with an anti-backflow valve to ensure that saliva can only enter in one direction and prevent air or external impurities from entering the sample;

[0013] The sample preservation module is connected to the anti-fouling module and the processing module. The collection device is provided with a preservation liquid storage chamber inside, which is separated from the saliva sample collection tube; the preservation liquid is mainly used to protect the activity of the virus in the sample;

[0014] The processing module is connected with the sample preservation module, the operation module, the data recording and tracking module, the sample transfer module, and the detection and processing module, and is used to store the sample at room temperature for a period of time after mixing, so as to avoid the sample becoming invalid due to unsuitable refrigeration conditions;

[0015] The operation module is connected to the processing module, and the collection device is provided with an operation indicator light and an audio prompt, and the user only needs to complete the saliva collection according to the prompt;

[0016] The data recording and tracking module is connected to the processing module and is used for the collection device. The QR code or barcode generation function can be optionally configured to automatically generate a unique identification code for each sample;

[0017] The sample transfer module is connected to the processing module and is used for the post-collection transfer process: after the collection is completed and the preservation fluid is added, the saliva sample tube is automatically sealed and has a leak-proof design to ensure the safe transfer of the sample;

[0018] The detection and processing module is connected to the processing module and is used for the collection device designed as a universal standard interface, which is compatible with most existing virus detection equipment and laboratory processes.

[0019] Furthermore, the acquisition module:

[0020] Structural design: The collection device consists of a collection tube with an adjustable scale and an ergonomically designed nozzle; the graduated tube is marked with multiple scale lines to accurately indicate the amount of saliva collected; the nozzle is connected to the graduated tube, and the saliva is introduced from the subject's mouth into the graduated tube through a straw or a built-in vacuum device;

[0021] Collection volume control: During the collection process, when saliva enters the graduated tube through the nozzle, the sensor will detect the amount of liquid in the graduated tube in real time; once the preset collection volume is reached, the sensor of the device will trigger the automatic closure of the nozzle valve, stop collection, and avoid excessive collection.

[0022] Furthermore, the anti-fouling module:

[0023] Anti-backflow valve design: The nozzle is equipped with an anti-backflow valve, which only allows saliva to enter the graduated tube in one direction, preventing external air, impurities or other potential contaminants from entering the collection tube and contaminating the sample during the collection process; the anti-backflow valve adopts a sealing structure to ensure airtightness during the collection process;

[0024] Automatic closing mechanism.

[0025] Furthermore, the automatic sealing mechanism: after the collection is completed, the nozzle will automatically close, sealing the entire collection tube to prevent the sample from being further exposed to the air; this sealing process can be achieved through electronic control or a mechanical spring trigger mechanism to ensure the sealing of the sample and effectively prevent contamination of the sample by the external environment.

[0026] Further, the operation module:

[0027] User prompt and guidance function: The collection device is equipped with an LED indicator light and an audio prompt device; after the device is powered on, the indicator light will light up to prompt the user to start collecting; when the collection volume reaches the predetermined requirement, the device will remind the user through sound to end the collection and automatically stop sucking saliva; the entire operation process is intuitive and simple, and the user can complete the collection without complicated operations;

[0028] Automatic cleaning and disinfection function.

[0029] Furthermore, the automatic cleaning and disinfection function: after the device is used, the device will automatically start the cleaning program; the cleaning liquid is sprayed onto the surface of the nozzle and the internal collection components through the pipe for thorough cleaning and disinfection to prevent cross infection; the disinfectant storage bin is separated from the collection pipe to ensure that each disinfection is completed independently, which is suitable for continuous use by multiple people.

[0030] Another object of the present invention is to provide an auxiliary saliva collection method for detecting infectious viruses in saliva, comprising:

[0031] Step 1: an adjustable graduated tube is built into the collection module, and different graduated lines are marked inside the tube to indicate the amount of saliva to be collected; an anti-fouling module is used to design an anti-backflow valve on the nozzle of the collection device to ensure that saliva can only enter in one direction, and prevent air or external impurities from entering the sample;

[0032] Step 2, using the sample preservation module to use a collection device with a preservation liquid storage chamber inside, which is separated from the saliva sample collection tube; the preservation liquid is mainly used to protect the activity of the virus in the sample;

[0033] Step 3: After mixing in the processing module, the sample can be stored at room temperature for a period of time to avoid sample failure due to inappropriate refrigeration conditions; the collection device is equipped with an operation indicator light and an audio prompt through the operation module, and the user only needs to complete the saliva collection according to the prompt;

[0034] Step 4: The data recording and tracking module uses the optional QR code or barcode generation function of the acquisition device to automatically generate a unique identification code for each sample;

[0035] Step 5, post-collection transfer process through the sample transfer module: After the collection is completed and the preservation solution is added, the saliva sample tube is automatically sealed and has a leak-proof design to ensure the safe transfer of the sample;

[0036] Step 6: The detection and processing module is designed as a universal standard interface using the collection device to adapt to most existing virus detection equipment and laboratory processes.

[0037] Another object of the present invention is to provide a computer device, comprising a memory and a processor, wherein the memory stores a computer program, and when the computer program is executed by the processor, the processor executes the steps of the auxiliary saliva collection method for detecting infectious viruses in saliva.

[0038] Another object of the present invention is to provide a computer-readable storage medium storing a computer program, which, when executed by a processor, enables the processor to perform the steps of the auxiliary saliva collection method for detecting infectious viruses in saliva.

[0039] Another object of the present invention is to provide an information data processing terminal, which is used to implement the intelligent auxiliary saliva collection device for detecting infectious viruses in saliva.

[0040] In combination with the above technical solutions and the technical problems solved, the advantages and positive effects of the technical solutions to be protected by the present invention are as follows:

[0041] First, accurately collect sample volume to improve detection accuracy: Through the built-in adjustable scale tube and automatic collection stop function, ensure that the collected saliva sample volume meets the detection requirements, reducing the risk of detection failure caused by substandard sample volume.

[0042] Avoid sample contamination and ensure the reliability of results: The design of anti-backflow valve and automatic closing nozzle can minimize the time that samples are exposed to the external environment, effectively prevent external contamination, and ensure the purity of samples.

[0043] Improved sample preservation technology: Through the automatic release function of the sample preservation fluid inside the collection device, the sample is preserved immediately after collection to avoid virus inactivation or sample degradation, thereby improving the accuracy of the test results and the convenience of sample preservation.

[0044] Easy to operate and user-friendly: The collection device is easy to operate, and users can collect saliva samples by themselves through simple steps, reducing the problem of substandard sample collection quality due to improper operation. It is suitable for a wide range of testing scenarios, especially in large-scale infectious virus screening, and has significant application advantages.

[0045] Overall effect: The intelligent auxiliary saliva collection device of the present invention solves the problems of difficult sample volume control, easy sample contamination, inconvenient storage and complicated operation in traditional saliva collection methods, and realizes more accurate, safe and convenient saliva collection and virus detection.

[0046] Second, in the existing virus detection process, there are many challenges in the collection and preservation of saliva samples. First, traditional sample collection methods usually rely on manual operations, which can easily lead to inaccurate sample collection, sample contamination, and operational errors. Secondly, sample preservation requirements are relatively strict, and usually rely on cold chain transportation to maintain the activity of the virus, which increases transportation costs and complexity. In addition, during the sample transfer process, poor sealing or improper operation can easily lead to sample leakage or cross-contamination, further affecting the accuracy of the test results and the safety of the samples.

[0047] The present invention solves the problems of inaccurate collection volume, sample contamination and complex storage conditions through an intelligent saliva collection device. First, the graduated tube design is adopted to ensure the accuracy of the collection volume; secondly, the anti-backflow valve design prevents external air or impurities from entering the sample to avoid sample contamination. In addition, the built-in preservation liquid storage chamber ensures that the sample can be automatically mixed with the preservation liquid after collection, maintains the activity of the virus, and reduces dependence on cold chain transportation. In the sample transfer process, the automatic sealing and leak-proof design is adopted to ensure the safety of the sample during transportation and avoid sample leakage and cross-contamination problems.

[0048] Compared with the prior art, the present invention has made significant technical progress in many aspects. Through the intelligent collection and operation prompt system, manual operation errors are reduced, ensuring the accuracy and consistency of sample collection. Anti-pollution and preservation technology allows samples to maintain viral activity at room temperature, greatly reducing the cost of transportation and preservation. At the same time, the automated sealing and identification system makes the sample transfer process safer and reduces the risk of cross contamination. The standardized detection interface improves the detection efficiency of the laboratory, allowing the collection device to adapt to most virus detection equipment.

[0049] The present invention has shown significant advantages in industrial applications. First, it reduces human intervention and operational errors, significantly improving the quality and efficiency of sample collection. Secondly, samples can remain active at room temperature, reducing cold chain transportation costs and increasing the flexibility of collection in remote and remote areas. In addition, the safety of the sample transfer process is greatly improved, avoiding sample leakage and contamination problems. Overall, the present invention provides a set of efficient, safe and cost-effective solutions for the virus detection industry through intelligent and standardized design.

[0050] Effect comparison table:

[0051]

[0052] It can be seen from the above comparison table that the present invention has significant technical improvements in collection accuracy, storage convenience and sample transfer safety, and effectively solves the key problems in traditional detection methods. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] Figure 1 It is a structural block diagram of an intelligent auxiliary saliva collection device for detecting infectious viruses in saliva provided by an embodiment of the present invention.

[0054] Figure 2 It is a flow chart of the operation module method provided by an embodiment of the present invention.

[0055] Figure 3 It is a flow chart of an auxiliary saliva collection method for detecting infectious viruses in saliva provided by an embodiment of the present invention.

[0056] Figure 1 In: 1. Collection module; 2. Anti-fouling module; 3. Sample preservation module; 4. Processing module; 5. Operation module; 6. Data recording and tracking module; 7. Sample transfer module; 8. Detection and processing module. DETAILED DESCRIPTION

[0057] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0058] In order to describe in detail the device name, model and working principle of each module in the device, we can step by step analyze the key components required for each module and their functions:

[0059] 1. Collection module:

[0060] Equipment name and model: Adjustable scale tube (optional models: TPG-01 or SPG-02, etc.)

[0061] How it works: The inside of the graduated tube is set with multiple scale lines to indicate the amount of saliva the user needs. The graduated tube is usually made of food-grade plastic or medical-grade silicone, which can withstand the chemical composition of saliva, and its transparent design makes it easy for users to see the amount of saliva collected. The user can control the amount of saliva required by the adjustable knob at the bottom of the graduated tube.

[0062] 2. Anti-fouling module:

[0063] Equipment name and model: Anti-backflow valve (model: ANV-100 or MVR-50)

[0064] Working principle: The anti-backflow valve is designed at the mouthpiece to ensure that saliva can only enter the collection device in one direction. The valve consists of a spring and a silicone pad. When the user inhales saliva, the valve opens, and after the collection is completed, the spring pushes the valve to close, preventing outside air or impurities from entering the collection sample, ensuring the purity of the sample.

[0065] 3. Sample storage module:

[0066] Equipment name and model: Storage chamber for preservation solution (e.g. PBS buffer storage chamber, model may be LSC-101 or LSR-150)

[0067] Working principle: The preservation solution storage chamber is isolated from the saliva sample collection tube to prevent the preservation solution from direct contact with the saliva. The working principle of this module is that after the collection is completed, the operation module triggers a micro electric valve to allow the preservation solution to enter the saliva sample tube through the pipeline. The function of the preservation solution is to maintain the activity of the virus in the sample, and PBS buffer or similar preservation solution is usually used.

[0068] 4. Processing module:

[0069] Equipment name and model: Mixing device (e.g. Mini Oscillator VM-10 or MixLab-01)

[0070] Working principle: The module mixes saliva and preservation solution thoroughly through a micro-oscillator. The mixed sample can be stored at room temperature for a certain period of time, avoiding the risk of sample failure due to inappropriate refrigeration conditions. The processing module monitors the mixing status through integrated sensors and ensures automatic stop at the appropriate time.

[0071] 5. Operation module:

[0072] Equipment name and model: Operation indicator light and sound prompt device (model LT-05LED or SND-02)

[0073] Working principle: The indicator light and sound prompt device guide the user to perform the correct operation. During operation, when the user completes each step, the device will prompt the user to the next step through different colors of LED lights (for example, green for operation completion, red for error) and sound, which simplifies the collection process.

[0074] 6.Data recording and tracking module:

[0075] Device name and model: QR code / barcode generator (e.g. QRX-300 or BCS-700)

[0076] Working principle: This module generates a unique QR code or barcode for each sample, which facilitates the tracking and recording of samples. The QR code / barcode generator is connected to the internal acquisition processing module, and automatically generates and prints a unique identification code based on the time when the acquisition is completed, user ID and other information.

[0077] 7. Sample transfer module:

[0078] Equipment name and model: Automatic sealing and leak-proof design tube (model STM-10 or LeakProof-01)

[0079] Working principle: After the saliva is collected and the preservation solution is added, the module drives the sealing device through a micro motor to automatically seal the collection tube. The sealing design adopts a double sealing layer structure to prevent the preservation solution and sample from leaking during the transfer process. After the transfer module detects that the seal is intact, it will also prompt the user through the indicator light that the sample has been safely sealed.

[0080] 8. Detection and processing module:

[0081] Device name and model: Universal Standard Interface Adapter (model UIA-01 or Universal Adapter V2)

[0082] Working principle: This module ensures that the collection device can adapt to most virus detection equipment. The universal standard interface is designed to comply with ISO international standards and can be directly plugged into the virus detection instrument. Through this interface, samples can be quickly transferred to the detection equipment for further processing, ensuring the consistency and convenience of laboratory processes.

[0083] The various modules of this intelligent assisted saliva collection device work together to efficiently and safely complete the collection, storage and transfer of saliva samples, and are compatible with most existing virus detection equipment. The advantage of this modular design is that the equipment and functions of each module can be replaced or upgraded according to different needs, thus providing a flexible solution.

[0084] The knob is connected to the adjustment mechanism of the graduated tube through a gear transmission system. When the user rotates the knob, the gear system pushes the graduated tube up and down, thereby accurately adjusting the amount of saliva collected. In addition, the graduated tube has an anti-slip design to ensure that the user can easily adjust it during operation.

[0085] The spring of the anti-backflow valve is made of stainless steel and is corrosion-resistant, while the silicone pad is made of medical-grade silicone to ensure that the saliva sample will not be contaminated during use. The anti-backflow valve also has an automatic locking function after the user completes the collection to further prevent external contaminants from entering the collection tube.

[0086] The micro electric valve is equipped with a flow sensor and a temperature sensor to ensure that the preservation solution maintains the optimal flow rate and temperature during the transmission process, avoiding the impact of too fast flow or improper temperature on the stability of the sample. The entry process of the preservation solution is automatically controlled by the processing module, and the user does not need to operate manually.

[0087] like Figure 1 As shown, an intelligent auxiliary saliva collection device for detecting infectious viruses in saliva provided by an embodiment of the present invention includes:

[0088] Collection module 1, anti-fouling module 2, sample storage module 3, processing module 4, operation module 5, data recording and tracking module 6, sample transfer module 7, detection and processing module 8;

[0089] The collection module 1 is connected to the anti-fouling module 2 and is used for collecting a saliva. The collection device has an adjustable graduated tube with different graduations inside to indicate the amount of saliva to be collected.

[0090] The anti-fouling module 2 is connected to the collection module 1 and the sample storage module 3. The nozzle of the collection device is designed with an anti-backflow valve to ensure that saliva can only enter in one direction and prevent air or external impurities from entering the sample;

[0091] The sample preservation module 3 is connected to the anti-fouling module 2 and the processing module 4. The collection device is provided with a preservation liquid storage chamber inside, which is separated from the saliva sample collection tube; the preservation liquid is mainly used to protect the activity of the virus in the sample;

[0092] The processing module 4 is connected to the sample storage module 3, the operation module 5, the data recording and tracking module 6, the sample transfer module 7, and the detection and processing module 8, and is used to store the sample at room temperature for a period of time after mixing, so as to avoid the sample becoming invalid due to unsuitable refrigeration conditions;

[0093] The operation module 5 is connected to the processing module 4, and the collection device is provided with an operation indicator light and an audio prompt, and the user only needs to complete the saliva collection according to the prompt;

[0094] The data recording and tracking module 6 is connected to the processing module 4 and is used for the collection device, which can be equipped with a QR code or barcode generation function to automatically generate a unique identification code for each sample;

[0095] The sample transfer module 7 is connected to the processing module 4 and is used for the post-collection transfer process: after the collection is completed and the preservation solution is added, the saliva sample tube is automatically sealed and has a leak-proof design to ensure the safe transfer of the sample;

[0096] The detection and processing module 8 is connected to the processing module 4 and is used for collecting data. The device is designed as a universal standard interface and is compatible with most existing virus detection equipment and laboratory processes.

[0097] The acquisition module provided by the embodiment of the present invention:

[0098] Structural design: The collection device consists of a collection tube with an adjustable scale and an ergonomically designed nozzle; the graduated tube is marked with multiple scale lines to accurately indicate the amount of saliva collected; the nozzle is connected to the graduated tube, and the saliva is introduced from the subject's mouth into the graduated tube through a straw or a built-in vacuum device;

[0099] Collection volume control: During the collection process, when saliva enters the graduated tube through the nozzle, the sensor will detect the amount of liquid in the graduated tube in real time; once the preset collection volume is reached, the sensor of the device will trigger the automatic closure of the nozzle valve, stop collection, and avoid excessive collection.

[0100] The anti-fouling module provided by the embodiment of the present invention:

[0101] Anti-backflow valve design: The nozzle is equipped with an anti-backflow valve, which only allows saliva to enter the graduated tube in one direction, preventing external air, impurities or other potential contaminants from entering the collection tube and contaminating the sample during the collection process; the anti-backflow valve adopts a sealing structure to ensure airtightness during the collection process;

[0102] Automatic closing mechanism.

[0103] The automatic sealing mechanism provided by the embodiment of the present invention: after the collection is completed, the nozzle will automatically close to seal the entire collection tube to prevent the sample from being further exposed to the air; this sealing process can be achieved through electronic control or a mechanical spring trigger mechanism to ensure the sealing of the sample and effectively prevent the external environment from contaminating the sample.

[0104] like Figure 2 As shown, the operation module provided by the embodiment of the present invention is:

[0105] S101, user prompt and guidance function: the collection device is equipped with an LED indicator light and an audio prompt device; after the device is powered on, the indicator light will light up to prompt the user to start collecting; when the collection volume reaches the predetermined requirement, the device will remind the user through sound to end the collection and automatically stop sucking saliva; the entire operation process is intuitive and simple, and the user can complete the collection without complicated operations;

[0106] S102, automatic cleaning and disinfection function.

[0107] The automatic cleaning and disinfection function provided by the embodiment of the present invention: after the device is used, the device will automatically start the cleaning program; the cleaning liquid is sprayed onto the surface of the suction nozzle and the internal collection components through the pipe to perform thorough cleaning and disinfection to prevent cross infection; the disinfectant storage bin is separated from the collection pipe to ensure that each disinfection is completed independently, which is suitable for continuous use by multiple people.

[0108] like Figure 3 As shown, an auxiliary saliva collection method for detecting infectious viruses in saliva provided by an embodiment of the present invention includes:

[0109] S201, an adjustable graduated tube is built into the collection module, and different graduated lines are marked inside the tube to indicate the amount of saliva to be collected; an anti-fouling module is used to design an anti-backflow valve on the nozzle of the collection device to ensure that saliva can only enter in one direction, and prevent air or external impurities from entering the sample;

[0110] S202, using a sample preservation module to provide a preservation liquid storage chamber inside the collection device, which is separated from the saliva sample collection tube; the preservation liquid is mainly used to protect the activity of the virus in the sample;

[0111] S203, after mixing by the processing module, the sample can be stored at room temperature for a period of time to avoid sample failure due to inappropriate refrigeration conditions; the collection device is provided with an operation indicator light and an audio prompt by the operation module, and the user only needs to complete the saliva collection according to the prompt;

[0112] S204, automatically generating a unique identification code for each sample by using the data recording and tracking module using the optional QR code or barcode generation function of the acquisition device;

[0113] S205, post-collection transfer process through the sample transfer module: after the collection is completed and the preservation solution is added, the saliva sample tube is automatically sealed and has a leak-proof design to ensure the safe transfer of the sample;

[0114] S206, the detection and processing module is designed as a universal standard interface using the collection device, which is adapted to most existing virus detection equipment and laboratory processes.

[0115] The collection module uses a built-in adjustable graduated tube to accurately control the amount of saliva collected. There are clear graduations in the graduated tube, so users can collect a specified amount of saliva according to their needs, avoiding collecting too much or too little sample. In order to prevent the sample from being contaminated during the collection process, the nozzle of the collection device is designed with an anti-backflow valve to ensure that saliva can only enter the collection tube in one direction, preventing air or external impurities from entering, protecting the purity of the sample, and ensuring the accuracy of the test results.

[0116] The sample preservation module is separated from the saliva sample collection tube by a built-in preservation liquid storage chamber. The preservation liquid is automatically released after the sample is collected and mixed with the saliva. The function of this preservation liquid is to maintain the activity of the virus in the sample and prevent the sample from becoming ineffective due to improper storage. After the mixing is completed, the sample can be stored at room temperature for a period of time, reducing the dependence on refrigeration conditions and avoiding sample failure during transportation or storage. The entire process helps users easily complete the saliva collection operation and reduce the complexity of the operation through the operation indicator light and sound prompts of the collection device.

[0117] In order to uniquely identify each sample, the system generates a unique identification code for each sample through the data recording and tracking module, and uses QR code or barcode technology to record sample information. This identification code can track key information such as the source and collection time of the sample to ensure that information is not confused or lost during sample transfer and testing. After the collection is completed and the preservation fluid is added, the saliva sample tube is automatically sealed. The leak-proof design ensures that there will be no leakage or environmental contamination during sample transportation, and the sample can be safely transferred to the testing laboratory.

[0118] The collection device is designed with a universal standard interface, so that the sample tube can be adapted to most virus detection equipment and laboratory processes on the market. The detection and processing module ensures that saliva samples can directly enter the existing virus detection system without complicated transfer or processing procedures, greatly improving the detection efficiency. Through this standardized interface, the laboratory can quickly connect the sample to the detection equipment for virus detection, making the entire process more efficient and highly compatible.

[0119] Specific implementation plan:

[0120] 1. Collection module design and operation

[0121] The collection module is the core component of the entire system. It has a built-in adjustable graduated tube with clear graduations to help users accurately collect the required amount of saliva. The user puts the nozzle of the collection device into the mouth and completes the saliva collection process by gently sucking. In order to prevent external impurities or air from entering the sample, the nozzle is designed with an anti-backflow valve so that saliva can only flow into the collection tube in one direction, ensuring that the collected saliva sample is pure and uncontaminated. The design of this module ensures the simplicity of user operation and the high quality of the sample.

[0122] 2. Design and operation of antifouling and preservation fluid module

[0123] In order to maintain the activity of the virus in the sample, an independent preservation liquid storage chamber is set inside the collection device, which is separated from the saliva sample collection tube. After the collection is completed, the device will automatically release the preservation liquid and mix it with the saliva sample. The preservation liquid contains special ingredients that can maintain the stability of the sample without destroying the virus structure and prevent the sample from becoming invalid before testing. At the same time, the mixed sample can be stored at room temperature for a period of time, reducing dependence on cold chain transportation and improving the convenience and flexibility of the entire sampling process.

[0124] 3. Operation prompts and guidance function design

[0125] The collection device is equipped with an operation indicator light and an audio prompt. The user only needs to complete the saliva collection according to the prompt. The indicator light will change color according to the different collection stages. For example, green means that the collection can start, yellow means that the collection is in progress, and red means that the collection volume has reached the set standard. The audio prompt function will sound a prompt when the collection is completed to remind the user to proceed to the next step. This design simplifies the user's operation steps, reduces the risk of misoperation, and provides reliable real-time feedback for the collection process.

[0126] 4. Sample automatic sealing and leak-proof design

[0127] After the sample is collected and the preservation solution is added, the sample tube of the collection device will automatically seal. The closed system adopts a double seal design to ensure that the sample will not leak due to loose sealing after collection. At the same time, the sample tube adopts a leak-proof structure. Even if the sample tube is tilted or inverted during transportation or movement, the saliva sample will not leak. This design improves the safety of the sample, especially in long-distance transportation or large-volume sample processing, and can effectively prevent sample leakage or cross-contamination.

[0128] 5. Sample identification and tracking design

[0129] Each sample collection device is equipped with an independent QR code or barcode generation system to generate a unique identification code for each collected sample. This identification code not only records the source of the sample, but also includes key information such as the collection time and collector information. Users can scan the QR code or barcode to directly enter it into the laboratory management system to achieve full-process tracking of the sample. This identification system greatly improves the transparency and traceability of sample management, ensuring that each sample will not be confused during the testing process.

[0130] 6. Sample room temperature storage function design

[0131] This solution ensures that the sample can be stored at room temperature for a period of time after collection through the use of preservation fluid. The preservation fluid not only maintains the activity of the virus, but also avoids the high cost and complexity of traditional cold chain storage. Experimental verification shows that saliva samples can remain effective for at least 48 hours at room temperature, which greatly improves the flexibility of sample storage and transportation, and is particularly suitable for sampling in small laboratories or remote areas that do not have cold chain conditions.

[0132] 7. Sample transfer module design

[0133] After collection, the sample tube is sealed with automatic sealing technology, and the leak-proof design of the sample tube makes it suitable for safe transfer under different transportation conditions. Laboratory or transportation personnel can directly obtain sample information through code scanning technology without repeated labeling or filling out additional forms. This module combines intelligent tracking function and safe transfer design to ensure that samples can be safely and quickly transferred to the testing center after collection, improving the safety and efficiency of the entire process.

[0134] 8. Universal detection interface and adaptability design

[0135] The sample tube design of the collection device complies with common laboratory testing standards and is compatible with most existing virus testing equipment. This standardized interface reduces the laboratory's adaptation requirements for sample processing, directly inserting the sample tube into the testing equipment for testing, simplifying the operation steps, and improving the speed and accuracy of testing. This design is not only suitable for the current virus testing process, but can also further optimize the testing process based on future upgrades in testing technology.

[0136] The present invention is specifically implemented:

[0137] 1. Design for precise control of collection volume

[0138] Structural design: The collection device consists of a collection tube with an adjustable scale and an ergonomically designed nozzle. The graduated tube is marked with multiple scale lines to accurately indicate the amount of saliva collected. The nozzle is connected to the graduated tube and saliva is introduced from the subject's mouth into the graduated tube through a straw or a built-in vacuum system.

[0139] Collection volume control: During the collection process, when saliva enters the graduated tube through the nozzle, the sensor will detect the amount of liquid in the graduated tube in real time. Once the preset collection volume is reached, the sensor of the device will trigger the automatic closure of the nozzle valve to stop collection and avoid excessive collection. This design ensures precise control of the collection volume, improves sample consistency and reliability of test results.

[0140] 2. Sample anti-contamination design

[0141] Anti-backflow valve design: The nozzle is equipped with an anti-backflow valve, which only allows saliva to enter the graduated tube in one direction, preventing external air, impurities or other potential contaminants from entering the collection tube and contaminating the sample during the collection process. The anti-backflow valve adopts a sealed structure to ensure airtightness during the collection process.

[0142] Automatic sealing mechanism: After the collection is completed, the nozzle will automatically close, sealing the entire collection tube to prevent the sample from being further exposed to the air. This sealing process can be achieved through electronic control or mechanical spring triggering mechanism to ensure the sealing of the sample and effectively prevent the external environment from contaminating the sample.

[0143] 3. Sample storage and processing module

[0144] Preservative fluid separation module: There is a preservation fluid storage chamber inside the collection device, which is separated from the saliva sample collection tube. The preservation fluid is mainly used to protect the activity of the virus in the sample and prevent the virus from being inactivated after collection. After the collection is completed, the preservation fluid storage chamber releases an appropriate amount of preservation fluid through an automatic valve, which mixes with the saliva sample to fix the virus.

[0145] Sample processing and storage: After mixing, the sample can be stored at room temperature for a period of time to avoid sample failure due to inappropriate refrigeration conditions. The preservation solution not only has the function of fixing viruses, but also can inhibit the activity of enzymes or bacteria in the sample, ensuring sample stability and providing high-quality sample conditions for subsequent laboratory testing.

[0146] 4. Ease of operation

[0147] User prompt and guidance function: In order to facilitate the operation of the subjects, the collection device is equipped with an LED indicator light and an audio prompt system. After the device is powered on, the indicator light will light up to prompt the user to start collecting. When the collection volume reaches the predetermined requirement, the device will remind the user through sound to end the collection and automatically stop sucking saliva. The entire operation process is intuitive and simple, and the user can complete the collection without complicated operations.

[0148] Automatic cleaning and disinfection function: After the device is used, the system will automatically start the cleaning program. The cleaning liquid is sprayed onto the nozzle and the surface of the internal collection components through the pipe for thorough cleaning and disinfection to prevent cross infection. The disinfectant storage bin is separated from the collection pipe to ensure that each disinfection is completed independently, which is suitable for continuous use by multiple people.

[0149] 5. Overall system integration and convenient operation

[0150] Modular design and portability: The collection device adopts a modular design, which is easy to disassemble and clean, and easy to carry and operate on site. The device is made of lightweight and durable materials and can be used outdoors or in mobile testing environments. The subject can operate it with one hand, which is convenient for large-scale screening and testing scenarios.

[0151] Data recording and tracking: The collection device can be equipped with a QR code or barcode generation function to automatically generate a unique identification code for each sample. Through the data recording module, the collection device can record key data such as sample collection time and sample volume, and synchronize with the detection system to ensure the full tracking of samples from collection to detection.

[0152] 6. Sample transfer and subsequent testing and processing

[0153] Post-collection transfer process: After the collection is completed and the preservation solution is added, the saliva sample tube is automatically sealed and has a leak-proof design to ensure the safe transfer of the sample. When testing in the laboratory, the tester can extract the sample without opening the collection device, reducing the risk of sample exposure and contamination.

[0154] Laboratory processing compatibility: The collection device is designed with a universal standard interface, which is compatible with most existing virus detection equipment and laboratory processes, ensuring the compatibility and ease of operation of subsequent detection processes.

[0155] Summarize:

[0156] This implementation method significantly improves the accuracy, safety and user experience of saliva sample collection by precisely controlling the sample collection volume, anti-contamination design, preservation fluid separation module and simple operation functions, ensuring the stability and integrity of the collected samples during the testing process, and is particularly suitable for the detection and large-scale screening of infectious viruses.

[0157] The following is a specific implementation case based on the scenario of the intelligent assisted saliva collection device described above being applied to COVID-19 virus detection:

[0158] Implementation case: COVID-19 saliva detection collection device

[0159] In response to the large-scale virus testing needs of COVID-19, an auxiliary device dedicated to collecting saliva samples was designed to simplify the collection process, ensure the integrity and safety of the samples, and improve the efficiency of laboratory testing.

[0160] 1. Implementation of the acquisition module:

[0161] Equipment name: TPG-01 transparent adjustable scale tube

[0162] Working process: After the user opens the collection device, put the nozzle of the device into the mouth and gently spit saliva into the graduated tube. Through the transparent graduated tube, the user can clearly see the amount of saliva. When the preset scale (for example, 2mL) is reached, the device will automatically lock the collection to prevent excessive collection.

[0163] 2. Implementation of anti-fouling module:

[0164] Equipment name: ANV-100 anti-backflow valve

[0165] Working process: The nozzle of the device is designed with a built-in anti-backflow valve to ensure that saliva can only enter the collection tube and will not flow back. At the same time, it prevents outside air or other impurities in the mouth from entering the sample, thereby improving the accuracy of the test.

[0166] 3. Implementation of sample storage module:

[0167] Equipment name: LSC-101 preservation solution storage chamber

[0168] Working process: After the saliva collection is completed, the processing module of the device triggers the micro-electric valve, and the preservation solution (such as PBS buffer) automatically enters the collection tube and mixes with the saliva sample to ensure that the virus in the sample remains active during transfer and storage. The preservation solution has anti-viral degradation function and can maintain the stability of the sample for 24 hours at room temperature.

[0169] 4. Implementation of operation module:

[0170] Device name: LT-05LED indicator light

[0171] Working process: The collection device is equipped with indicator lights and sound prompt systems. The user will receive corresponding prompts during the collection process, for example: a green light indicates that the collection can begin, a yellow light indicates that the collection volume does not meet the standard, and a red light indicates an incorrect operation. After the collection is completed, the device will issue a sound prompt to instruct the user to complete all steps.

[0172] 5. Implementation of data recording and tracking module:

[0173] Device name: QRX-300 QR code generator

[0174] Working process: After each saliva collection, the collection device will generate a unique QR code for the sample, recording the relevant collection time, location and user information. The QR code can be used to track the flow of samples in the future to ensure the reliability of the test data.

[0175] 6. Implementation of sample transfer module:

[0176] Equipment name: STM-10 automatic sealing tube

[0177] Working process: After the saliva and preservation solution are mixed, the automatic sealing device will be activated to ensure that the sample tube is completely sealed and prevent sample leakage through the double-layer structure. This design meets transportation requirements and can safely transfer samples without the need for a cold chain.

[0178] 7. Implementation of detection and processing module:

[0179] Device Name: UIA-01 Universal Interface Adapter

[0180] Working process: After collection, the sample can be directly transferred to the COVID-19 virus detection equipment for testing through the UIA-01 universal standard interface adapter. This adapter complies with ISO standards and can be adapted to mainstream PCR detection equipment to improve laboratory processing efficiency.

[0181] Through this intelligent assisted saliva collection device, the entire process of COVID-19 virus saliva sample collection has become simpler and more efficient. Automated operation reduces human error and prevents sample contamination, while ensuring that samples can be safely stored and transported under standard conditions. In addition, the QR code tracking system also improves the efficiency of sample management, making large-scale testing possible.

[0182] This device has been widely used in scenarios such as schools, companies, and communities. Users can complete the collection on their own without professional training, which greatly reduces the pressure on the medical system and speeds up the output of test results.

[0183] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any modifications, equivalent substitutions and improvements made by any technician familiar with the technical field within the technical scope disclosed by the present invention and within the spirit and principle of the present invention should be covered by the protection scope of the present invention.

Claims

1. An intelligent auxiliary saliva collection device for detecting infectious viruses in saliva, characterized in that: include: A collection module, wherein the collection module has an adjustable graduated tube built therein, and the graduated tube is marked with different graduation lines for indicating the amount of saliva to be collected; An anti-fouling module, the anti-fouling module includes an anti-backflow valve, the anti-backflow valve ensures that saliva can only enter the collection device in one direction, and prevents external air or impurities from entering the sample; A sample preservation module, wherein the sample preservation module is provided with a preservation liquid storage chamber, wherein the preservation liquid storage chamber is used to isolate the preservation liquid from the collected saliva sample, and after the collection is completed, the preservation liquid is automatically added to the saliva sample to protect the activity of the virus in the sample; An operation module, wherein the operation module has an operation indicator light and an audio prompt, and the user completes saliva collection according to the instructions; A data recording and tracking module, wherein the module is equipped with a QR code or bar code generator for generating a unique identification code for each sample for tracking; A sample transfer module, wherein the sample transfer module includes an automatic sealing device, and after the collection is completed and the preservation liquid is added, the saliva sample tube is automatically sealed to prevent leakage; The detection and processing module is equipped with a universal standard interface adapter, which can adapt to most virus detection equipment and ensure the rapid transfer and detection processing of samples.

2. The intelligent auxiliary saliva collection device for detecting infectious viruses in saliva as claimed in claim 1, characterized in that: The acquisition module: Structural design: The collection device consists of a collection tube with an adjustable scale and an ergonomically designed nozzle; the graduated tube is marked with multiple scale lines to accurately indicate the amount of saliva collected; the nozzle is connected to the graduated tube, and the saliva is introduced from the subject's mouth into the graduated tube through a straw or a built-in vacuum device; Collection volume control: During the collection process, when saliva enters the graduated tube through the nozzle, the sensor will detect the amount of liquid in the graduated tube in real time; once the preset collection volume is reached, the sensor of the device will trigger the automatic closure of the nozzle valve, stop collection, and avoid excessive collection.

3. The intelligent auxiliary saliva collection device for detecting infectious viruses in saliva as claimed in claim 1, characterized in that: The antifouling module: Anti-backflow valve design: The nozzle is equipped with an anti-backflow valve, which only allows saliva to enter the graduated tube in one direction, preventing external air, impurities or other potential contaminants from entering the collection tube and contaminating the sample during the collection process; the anti-backflow valve adopts a sealing structure to ensure airtightness during the collection process; Automatic closing mechanism.

4. The intelligent auxiliary saliva collection device for detecting infectious viruses in saliva as claimed in claim 3, characterized in that: The automatic sealing mechanism: after the collection is completed, the nozzle will automatically close, sealing the entire collection tube to prevent the sample from being further exposed to the air; this sealing process can be achieved through electronic control or a mechanical spring trigger mechanism to ensure the sealing of the sample and effectively prevent the external environment from contaminating the sample.

5. The intelligent auxiliary saliva collection device for detecting infectious viruses in saliva as claimed in claim 1, characterized in that: The operation module: User prompt and guidance function: The collection device is equipped with an LED indicator light and an audio prompt device; after the device is powered on, the indicator light will light up to prompt the user to start collecting; when the collection volume reaches the predetermined requirement, the device will remind the user through sound to end the collection and automatically stop sucking saliva; the entire operation process is intuitive and simple, and the user can complete the collection without complicated operations; Automatic cleaning and disinfection function.

6. The intelligent auxiliary saliva collection device for detecting infectious viruses in saliva as claimed in claim 5, characterized in that: The automatic cleaning and disinfection function: after the device is used, the device will automatically start the cleaning program; the cleaning liquid is sprayed onto the surface of the suction nozzle and the internal collection components through the pipe for thorough cleaning and disinfection to prevent cross infection; the disinfectant storage bin is separated from the collection pipe to ensure that each disinfection is completed independently, which is suitable for continuous use by multiple people.

7. The intelligent auxiliary saliva collection device for detecting infectious viruses in saliva as claimed in claim 1, characterized in that: The knob is connected to the adjustment mechanism of the graduated tube through a gear transmission system. When the user rotates the knob, the gear system pushes the graduated tube up and down, thereby accurately adjusting the amount of saliva collected. In addition, the graduated tube has an anti-slip design to ensure that the user can easily adjust it during operation.

8. The intelligent auxiliary saliva collection device for detecting infectious viruses in saliva as claimed in claim 1, characterized in that: The spring of the anti-backflow valve is made of stainless steel and has corrosion resistance, while the silicone pad uses medical-grade silicone to ensure that the saliva sample will not be contaminated during use. The anti-backflow valve also has an automatic locking function after the user completes the collection to further prevent external contaminants from entering the collection tube.

9. The intelligent auxiliary saliva collection device for detecting infectious viruses in saliva as claimed in claim 1, characterized in that: The micro electric valve is equipped with a flow sensor and a temperature sensor to ensure that the preservation solution maintains the optimal flow rate and temperature during the transmission process, avoiding the influence of too fast flow or improper temperature on the stability of the sample. The entry process of the preservation solution is automatically controlled by the processing module, and the user does not need to operate manually.

10. An auxiliary saliva collection method for detecting infectious viruses in saliva using the intelligent auxiliary saliva collection device for detecting infectious viruses in saliva as claimed in any one of claims 1 to 9, characterized in that: The auxiliary saliva collection method for detecting infectious viruses in saliva comprises: Step 1: an adjustable graduated tube is built into the collection module, and different graduated lines are marked inside the tube to indicate the amount of saliva to be collected; an anti-fouling module is used to design an anti-backflow valve on the nozzle of the collection device to ensure that saliva can only enter in one direction, and prevent air or external impurities from entering the sample; Step 2, using the sample preservation module to use a collection device with a preservation liquid storage chamber inside, which is separated from the saliva sample collection tube; the preservation liquid is mainly used to protect the activity of the virus in the sample; Step 3: After mixing in the processing module, the sample can be stored at room temperature for a period of time to avoid sample failure due to inappropriate refrigeration conditions; the collection device is equipped with an operation indicator light and an audio prompt through the operation module, and the user only needs to complete the saliva collection according to the prompt; Step 4: The data recording and tracking module uses the optional QR code or barcode generation function of the acquisition device to automatically generate a unique identification code for each sample; Step 5, post-collection transfer process through the sample transfer module: After the collection is completed and the preservation solution is added, the saliva sample tube is automatically sealed and has a leak-proof design to ensure the safe transfer of the sample; Step 6: The detection and processing module is designed as a universal standard interface using the collection device to adapt to most existing virus detection equipment and laboratory processes.

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