Long-acting oil-controlling and dandruff-removing composition as well as preparation method and application thereof

Abstract

The invention discloses a long-acting oil-controlling and dandruff-removing composition as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The composition is prepared from selenium disulfide, decanediol, clomidazole, dipotassium glycyrrhizinate and a tea seed extract, the selenium disulfide is subjected to grinding treatment. The components in the composition can synergistically reduce irritation to skin and improve oil control and dandruff removal effects, and the composition is free of irritation to scalp, safe, mild and good in long-term effect.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a long-acting oil-controlling and anti-dandruff composition and a preparation method and application thereof. Background Art

[0002] Dandruff is a common scalp problem. Currently, commonly used anti-dandruff agents are mainly divided into three categories. The first category is keratin exfoliants such as salicylic acid, sulfur, and coal tar, which remove damaged epidermal cells in the stratum corneum by desquamation to achieve the effect of removing dandruff, but the products containing keratin exfoliants are more irritating and have poor odor. Long-term use will also destroy the epidermal structure, disrupt the ecological balance of the epidermis, and cause certain damage to the skin. The second category is cell growth inhibitors such as selenium disulfide, which inhibit cell replication and reduce the replacement rate of the stratum corneum to achieve the effect of removing dandruff. This is better for dandruff caused by oily scalp, but it is more irritating. The third category is antimicrobial preparations such as piroctone ethanolamine, clumibazole, and pyrithione zinc, which belong to the current mainstream anti-dandruff agents, which inhibit or destroy microbial growth to achieve the purpose of inhibiting dandruff, but there are problems of poor dandruff removal effect and repeated dandruff.

[0003] Therefore, it is important to develop a composition that is soothing, non-irritating, and has good oil control and anti-dandruff effects. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides an oil-controlling and anti-dandruff composition, which is soothing and non-irritating and has a good oil-controlling and anti-dandruff effect.

[0005] The invention also provides a method for preparing the composition.

[0006] The invention also provides a cosmetic.

[0007] The present invention also provides application of the composition in preparing a product having the function of inhibiting Malassezia furfur.

[0008] The present invention also provides application of the composition in preparing cosmetics.

[0009] A composition according to the first embodiment of the present invention comprises: selenium disulfide, decanediol, climbazole, dipotassium glycyrrhizinate, and tea seed extract;

[0010] The selenium disulfide is ground.

[0011] The composition according to the embodiment of the present invention has at least the following beneficial effects:

[0012] Selenium disulfide, decanediol, climbazole, dipotassium glycyrrhizinate, and tea seed extract can synergistically reduce irritation to the skin and improve the oil control and anti-dandruff effects. The composition of the embodiment has the effects of scalp oil control, repair, and soothing the scalp, is non-irritating to the scalp, safe and mild, can effectively remove dandruff, and has good long-term effectiveness. In addition, the cosmetics containing the composition have the advantages of uniformity and stability.

[0013] According to some embodiments of the present invention, the composition comprises, by weight:

[0014]

[0015] According to some embodiments of the present invention, the composition comprises, by weight:

[0016]

[0017] According to some embodiments of the present invention, the composition comprises, by weight:

[0018]

[0019] According to some embodiments of the present invention, the D 90 The thickness is 2 to 10 μm. For example, it can be 2 μm, 2.5 μm, 3 μm, 3.5 μm, 4 μm, 4.5 μm, 5 μm, 5.5 μm, 6 μm, 6.5 μm, 7 μm, 7.5 μm, 8 μm, 8.5 μm, 9 μm, 9.5 μm or 10 μm.

[0020] According to some embodiments of the present invention, the grinding process includes at least one of ball milling and sand milling. The grinding process can effectively disperse selenium disulfide and prevent it from agglomerating.

[0021] According to some embodiments of the present invention, the grinding process comprises the following steps:

[0022] A mixture of selenium disulfide and water is prepared and ground.

[0023] According to some embodiments of the present invention, the mass ratio of selenium disulfide to water is 1:8 to 25. For example, it can be 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:21, 1:22, 1:23, 1:24 or 1:25.

[0024] According to some embodiments of the present invention, the mixture further comprises a chelating agent. The mass ratio of selenium disulfide to the chelating agent is 1:0.00125-30. For example, it can be 1:0.04, 1:0.06, 1:0.08, 1:0.1, 1:0.5, 1:1, 1:2, 1:4, 1:6, 1:7, 1:10, 1:12, 1:14, 1:16, 1:18 or 1:20.

[0025] According to some embodiments of the present invention, the rotation speed of the ball milling process is 10 r / min to 25 r / min. For example, it can be 10 r / min, 11 r / min, 12 r / min, 13 r / min, 14 r / min, 15 r / min, 16 r / min, 17 r / min, 18 r / min, 19 r / min, 20 r / min, 21 r / min, 22 r / min, 23 r / min, 24 r / min or 25 r / min.

[0026] According to some embodiments of the present invention, the grinding time of the ball milling treatment is 5 min to 15 min, for example, 5 min, 6 min, 7 min, 8 min, 9 min, 10 min, 11 min, 12 min, 13 min, 14 min or 15 min.

[0027] According to some embodiments of the present invention, the temperature during the ball milling process is no higher than 35°C.

[0028] The method for preparing the above-mentioned composition according to the second aspect of the present invention comprises the following steps:

[0029] The composition is obtained by mixing the components.

[0030] A cosmetic according to the third aspect of the present invention comprises the composition as described in the first aspect of the present invention and cosmetically acceptable auxiliary materials. Since the cosmetic adopts all the technical solutions of the composition of the above embodiment, it at least has all the beneficial effects brought by the technical solutions of the above embodiment.

[0031] According to some embodiments of the present invention, the auxiliary material includes at least one of a conditioner, a chelating agent, a surfactant, an excipient, a thickener, a suspending agent, a suspending agent, a flavor, a preservative and a pH adjuster.

[0032] According to some embodiments of the present invention, if present, the cosmetic contains 0.05% to 0.8% of the conditioning agent by mass. The conditioning agent includes at least one of polyquaternium-10, polyquaternium-7, and guar hydroxypropyltrimonium chloride.

[0033] According to some embodiments of the present invention, if present, the cosmetic contains 0.05% to 0.5% of the chelating agent by mass. The chelating agent includes at least one of disodium EDTA, etidronate, and tetrasodium EDTA.

[0034] According to some embodiments of the present invention, if present, the cosmetic contains 7% to 20% of the surfactant by mass. The surfactant includes at least one of sodium laureth sulfate, ammonium laureth sulfate, cocamidopropyl betaine, sodium cocoyl isethionate, sodium methyl cocoyl taurate, sodium cocoyl methyl taurate, and disodium lauryl sulfosuccinate.

[0035] According to some embodiments of the present invention, if present, the cosmetic contains 0.5% to 5% of the thickener by mass. The thickener includes at least one of cocamide MEA and carbomer.

[0036] According to some embodiments of the present invention, if present, the cosmetic contains 0.1% to 2% of the suspending agent by mass. The suspending agent includes at least one of coconut trihydroxystearin, carbomer, and hydrogenated castor oil.

[0037] According to some embodiments of the present invention, if present, the cosmetic contains 0.3% to 1.5% of the essence by mass.

[0038] According to some embodiments of the present invention, if present, the cosmetic contains 0.05% to 0.3% of the preservative by mass, wherein the preservative comprises at least one of phenoxyethanol, sodium benzoate, potassium sorbate and p-anisic acid.

[0039] According to some embodiments of the present invention, if present, the cosmetic contains 0.01% to 5% of the pH adjuster by mass. The pH adjuster includes at least one of citric acid, sodium citrate, lactic acid, and aminomethyl propanol.

[0040] According to some embodiments of the present invention, the cosmetic contains 0.01% to 40% of the above composition by mass, for example, 0.1%, 0.5%, 1%, 2%, 4%, 6%, 8%, 10%, 12%, 14%, 16%, 18%, 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38% or 40%.

[0041] The use of the above-mentioned composition according to the fourth aspect of the present invention in the preparation of a product having the effect of inhibiting Malassezia furfur.

[0042] According to the fifth aspect of the present invention, the composition is used in the preparation of cosmetics.

[0043] According to some embodiments of the present invention, the cosmetic has anti-dandruff and / or oil-control effects.

[0044] According to some embodiments of the present invention, the cosmetic is selected from shampoo, scalp care lotion, conditioner, scalp care cream, scalp essence or hair mask.

[0045] Other features and advantages of the present invention will be set forth in the description which follows, and in part will be apparent from the description, or may be learned by practice of the present invention. DETAILED DESCRIPTION

[0046] The following will be combined with the embodiments to clearly and completely describe the concept of the present invention and the technical effects produced, so as to fully understand the purpose, characteristics and effects of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without creative work are all within the scope of protection of the present invention.

[0047] If the specific conditions are not specified in the examples, the experiments were carried out under conventional conditions or conditions recommended by the manufacturer. If the manufacturers of the reagents or instruments are not specified, they are all conventional products that can be purchased commercially.

[0048] When a numerical range is disclosed herein, the above range is considered to be continuous and includes the minimum and maximum values ​​of the range, as well as every value between such minimum and maximum values. Further, when a range refers to an integer, every integer between the minimum and maximum values ​​of the range is included. In addition, when multiple ranges are provided to describe features or characteristics, the ranges can be combined. In other words, unless otherwise indicated, all ranges disclosed herein should be understood to include any and all subranges included therein.

[0049] "Mass fraction" refers to the basic unit of measurement that indicates the mass ratio of multiple components. 1 part can represent any unit mass, such as 1g or 2.689g. If we say that the mass fraction of component A is a parts and the mass fraction of component B is b parts, it means the ratio of the mass of component A to the mass of component B is a:b. Alternatively, it means that the mass of component A is aK and the mass of component B is bK (K is an arbitrary number, indicating a multiple factor). It should not be misunderstood that, unlike mass fraction, the sum of the mass fractions of all components is not limited to 100 parts.

[0050] Unless otherwise specified, "room temperature" in the present invention means (25±5)°C.

[0051] "And / or" is used to indicate that one or both of the stated situations may occur, for example, A and / or B includes (A and B) and (A or B).

[0052] In the present invention, tea seed extract (INCI name: CAMELLIA SINENSIS SEED EXTRACT) was purchased from Guangzhou Novi Biotechnology Co., Ltd.; selenium disulfide was purchased from Zhejiang Lijing Chemical Co., Ltd., and D 90 The particle size of the sample was 9.249 μm (confirmed by Bettersize 2600 laser particle size distribution analyzer (wet method)); decanediol was purchased from Guangzhou Novae Biotechnology Co., Ltd.; climbazole was purchased from Zhejiang Lijing Chemical Co., Ltd.; dipotassium glycyrrhizinate was purchased from Gansu Panzhi Pharmaceutical Co., Ltd.; salicylic acid was purchased from Guangzhou Novae Biotechnology Co., Ltd.; glycerol was purchased from Deyuan (China) Hi-Tech Co., Ltd.; piroctone olamine salt was purchased from Clariant Chemical Technology (Shanghai) Co., Ltd.; HAMAMELIS VIRGINIANA floral water was purchased from Guangzhou Novae Biotechnology Co., Ltd.; and tea tree extract was purchased from Guangzhou Novae Biotechnology Co., Ltd.

[0053] Example

[0054] This example provides eight long-acting oil-controlling and anti-dandruff compositions according to Examples 1 to 8, and the formulas are shown in Table 1 in parts by mass.

[0055] Table 1

[0056]

[0057] Comparative Example 1

[0058] This example provides a long-lasting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that selenium disulfide is not included.

[0059] Comparative Example 2

[0060] This example provides a long-lasting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that it does not include decanediol.

[0061] Comparative Example 3

[0062] This example provides a long-acting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that climbazole is not included.

[0063] Comparative Example 4

[0064] This example provides a long-lasting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that it does not include dipotassium glycyrrhizinate.

[0065] Comparative Example 5

[0066] This example provides a long-lasting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that it does not include tea seed extract.

[0067] Comparative Example 6

[0068] This example provides a long-acting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that it does not include selenium disulfide and climbazole.

[0069] Comparative Example 7

[0070] This example provides a long-lasting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that it does not include dipotassium glycyrrhizinate and decanediol.

[0071] Comparative Example 8

[0072] This example provides a long-lasting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that it does not include dipotassium glycyrrhizinate and tea seed extract.

[0073] Comparative Example 9

[0074] This example provides a long-acting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that selenium disulfide is replaced with an equal mass of salicylic acid.

[0075] Comparative Example 10

[0076] This example provides a long-lasting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that decanediol is replaced with an equal mass of glycerol.

[0077] Comparative Example 11

[0078] This example provides a long-acting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that climbazole is replaced with an equal mass of piroctone ethanolamine salt.

[0079] Comparative Example 12

[0080] This example provides a long-lasting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that dipotassium glycyrrhizinate is replaced with an equal mass of HAMAMELIS VIRGINIANA floral water.

[0081] Comparative Example 13

[0082] This example provides a long-lasting oil-controlling and anti-dandruff composition, which is basically the same as Example 1, except that the tea seed extract is replaced with an equal mass of tea tree extract.

[0083] Comparative Example 14

[0084] This example provides a long-acting oil-controlling and anti-dandruff composition, which is composed of 100 parts of selenium disulfide by mass.

[0085] Comparative Example 15

[0086] This example provides a long-lasting oil-controlling and anti-dandruff composition, which is composed of 100 parts of decanediol by weight.

[0087] Comparative Example 16

[0088] This example provides a long-acting oil-controlling and anti-dandruff composition, which is composed of 100 parts of climbazole by mass.

[0089] Comparative Example 17

[0090] This example provides a long-acting oil-controlling and anti-dandruff composition, which is composed of 100 parts of dipotassium glycyrrhizinate by mass.

[0091] Comparative Example 18

[0092] This example provides a long-acting oil-controlling and anti-dandruff composition, which is composed of 100 parts of tea seed extract by weight.

[0093] Application Example 1

[0094] This application example provides a shampoo, and the formula is shown in Table 2 in terms of mass percentage.

[0095] Table 2

[0096] Raw material name Mass percentage (%) Polyquaternium-10 0.15 Sodium Laureth Sulfate 16.5 Cocamidopropyl Betaine 5 Cocamide MEA 1.3 Disodium EDTA 0.1 Ethylene glycol distearate 1 Composition of Example 1 0.5 Carbomer 0.5 Polyquaternium-7 0.2 Phenoxyethanol 0.1 Sodium Benzoate 0.3 essence 0.5 Citric Acid 0.5 Sodium Citrate 0.1 water Top up to 100%

[0097] The preparation method of the shampoo comprises the following steps:

[0098] (1) Mix selenium disulfide, half of disodium EDTA, and water equivalent to 10 times the mass of selenium disulfide, control the ball milling temperature to no more than 32°C, and grind them homogeneously in a ball mill at a speed of 15 r / min for 12 minutes until D 90 The particle size was 2 to 10 μm, and a mixture A was obtained.

[0099] (2) Add polyquaternium-10 and the remaining disodium EDTA to an emulsifier, add the remaining water, stir homogenously, and disperse evenly to obtain phase A.

[0100] (3) Continue to add sodium laureth sulfate and cocamidopropyl betaine into the emulsifying pot, stir evenly, and heat to 80° C. to 85° C. to obtain a mixed solution.

[0101] (4) Continue to add cocamide MEA and ethylene glycol distearate into the emulsifying pot, stir at 80°C to 85°C for about 20 minutes, add climbazole and decanediol and stir for about 10 minutes.

[0102] (5) After the temperature drops to 50° C., add carbomer and stir evenly;

[0103] (6) After the temperature drops below 35° C., add tea seed extract and mixture A obtained in step (1) and stir evenly.

[0104] (7) Continue to add polyquaternium-7, phenoxyethanol, sodium benzoate, and essence, and adjust the pH to 4-5 with citric acid and sodium citrate to obtain shampoo.

[0105] Application Example 2

[0106] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 (added in an amount of 0.5%) in the shampoo is replaced by the composition of example 2 (added in an amount of 2%).

[0107] The preparation method of the shampoo is the same as that of Application Example 1.

[0108] Application Example 3

[0109] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo (added in an amount of 0.5%) is replaced by the composition of example 3 (added in an amount of 10%).

[0110] The preparation method of the shampoo is the same as that of Application Example 1.

[0111] Application Example 4

[0112] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 (added in an amount of 0.5%) in the shampoo is replaced by the composition of example 4 (added in an amount of 20%).

[0113] The preparation method of the shampoo is the same as that of Application Example 1.

[0114] Application Example 5

[0115] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 (added in an amount of 0.5%) in the shampoo is replaced by the composition of example 5 (added in an amount of 3%).

[0116] The preparation method of the shampoo is the same as that of Application Example 1.

[0117] Application Example 6

[0118] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 (added in an amount of 0.5%) in the shampoo is replaced by the composition of example 6 (added in an amount of 1.5%).

[0119] The preparation method of the shampoo is the same as that of Application Example 1.

[0120] Application Example 7

[0121] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 (added in an amount of 0.5%) in the shampoo is replaced by the composition of example 7 (added in an amount of 1%).

[0122] The preparation method of the shampoo is the same as that of Application Example 1.

[0123] Application Example 8

[0124] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 (added in an amount of 0.5%) in the shampoo is replaced by the composition of example 8 (added in an amount of 0.8%).

[0125] The preparation method of the shampoo is the same as that of Application Example 1.

[0126] Application Comparative Example 1

[0127] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that the composition of example 1 is omitted.

[0128] The preparation method of the shampoo is the same as that of Application Example 1.

[0129] Application Comparative Example 2

[0130] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced with an equal amount of the composition of comparative example 1.

[0131] The preparation method of the shampoo is the same as that of Application Example 1.

[0132] Application Comparative Example 3

[0133] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 2 in an equal amount.

[0134] The preparation method of the shampoo is the same as that of Application Example 1.

[0135] Application Comparative Example 4

[0136] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 3 in an equal amount.

[0137] The preparation method of the shampoo is the same as that of Application Example 1.

[0138] Application Comparative Example 5

[0139] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 4 in an equal amount.

[0140] The preparation method of the shampoo is the same as that of Application Example 1.

[0141] Application Comparative Example 6

[0142] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 5 in an equal amount.

[0143] The preparation method of the shampoo is the same as that of Application Example 1.

[0144] Application Comparative Example 7

[0145] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 6 in an equal amount.

[0146] The preparation method of the shampoo is the same as that of Application Example 1.

[0147] Application Comparative Example 8

[0148] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 7 in an equal amount.

[0149] The preparation method of the shampoo is the same as that of Application Example 1.

[0150] Application Comparative Example 9

[0151] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 8 in an equal amount.

[0152] The preparation method of the shampoo is the same as that of Application Example 1.

[0153] Application Comparative Example 10

[0154] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 9 in an equal amount.

[0155] The preparation method of the shampoo is the same as that of Application Example 1.

[0156] Application Comparative Example 11

[0157] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 10 in an equal amount.

[0158] The preparation method of the shampoo is the same as that of Application Example 1.

[0159] Application Comparative Example 12

[0160] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 11 in an equal amount.

[0161] The preparation method of the shampoo is the same as that of Application Example 1.

[0162] Application Comparative Example 13

[0163] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 12 in an equal amount.

[0164] The preparation method of the shampoo is the same as that of Application Example 1.

[0165] Application Comparative Example 14

[0166] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 13 in an equal amount.

[0167] The preparation method of the shampoo is the same as that of Application Example 1.

[0168] Application Comparative Example 15

[0169] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 14 in an equal amount.

[0170] The preparation method of the shampoo is the same as that of Application Example 1.

[0171] Application Comparative Example 16

[0172] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 15 in an equal amount.

[0173] The preparation method of the shampoo is the same as that of Application Example 1.

[0174] Application Comparative Example 17

[0175] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 16 in an equal amount.

[0176] The preparation method of the shampoo is the same as that of Application Example 1.

[0177] Application Comparative Example 18

[0178] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 17 in an equal amount.

[0179] The preparation method of the shampoo is the same as that of Application Example 1.

[0180] Application Comparative Example 19

[0181] This application example provides a shampoo, the formula of which is basically the same as that of application example 1, except that, in terms of mass percentage, the composition of example 1 in the shampoo is replaced by the composition of comparative example 18 in an equal amount.

[0182] The preparation method of the shampoo is the same as that of Application Example 1.

[0183] Application Comparative Example 20

[0184] This application example provides a shampoo, the formula of which is the same as that of application example 1.

[0185] The preparation method of the shampoo is basically the same as that of Application Example 1, except that: step (1) is omitted; disodium EDTA is added to an emulsifying pot together with cocamide MEA and ethylene glycol distearate in step (4); and selenium disulfide is directly added to the emulsifying pot in step (6).

[0186] Application Comparative Example 21

[0187] This application example provides a shampoo, the formula of which is the same as that of application example 1.

[0188] The preparation method of the shampoo is basically the same as that of Application Example 1, except that: Step (1) is different; disodium EDTA is added to the emulsifying pot together with cocamide MEA and ethylene glycol distearate in step (4). Step (1) is specifically as follows:

[0189] Selenium disulfide was mixed with 10 times the weight of water and homogenized for 3 minutes to obtain mixture A.

[0190] Test Example 1

[0191] This test example uses a closed test method to test the irritation of the shampoos of Application Examples 1 to 8 and Application Comparative Examples 1 to 21.

[0192] 90 subjects who met the voluntary inclusion criteria (35 males, 45 females, aged 20-55 years) were randomly divided into three groups, 30 in each group. The test substance (dosage of 0.02mL-0.025mL) was placed in a suitable spot tester, applied to the curved side of the subject's arm with a low-allergenic tape, and gently pressed with the palm of the hand to evenly apply it to the skin for 24 hours; the blank control group was a subject who did not use the product. After 24 hours, the spot tester was removed, and the skin reaction was observed after 0.5h, 24h, and 48h, and the reaction results were recorded. The adverse reaction levels of the skin are shown in Table 3, and the test results are shown in Table 4.

[0193] Table 3

[0194]

[0195] Table 4

[0196]

[0197]

[0198]

[0199] No adverse reactions occurred in the subjects who tried the shampoos of Examples 1 to 8, Comparative Examples 1 to 4, Comparative Examples 7 to 8, Comparative Examples 11 to 12, Comparative Examples 16, and Comparative Examples 18 to 19. One Grade 1 adverse reaction occurred in the subjects who tried the shampoos of Comparative Examples 5 to 6, Comparative Examples 9 to 10, Comparative Examples 13 to 14, Comparative Example 17, and Comparative Examples 20 to 21; and two Grade 1 adverse reactions occurred in the subjects who tried Comparative Example 15.

[0200] This indicates that selenium disulfide, decanediol, climbazole, dipotassium glycyrrhizinate and tea seed extract in the long-acting oil-controlling and anti-dandruff composition of the present invention can synergistically reduce irritation, and the prepared shampoo is safe, mild and non-irritating to the skin.

[0201] Test Example 2

[0202] This test example tests the stability of the shampoos of Application Examples 1 to 8 and Application Comparative Examples 1 to 21.

[0203] The shampoos of Application Examples 1 to 8 and Comparative Examples 1 to 21 were placed at room temperature, 48°C, and -15°C for 3 months respectively, and the changes in properties before and after storage under each condition were evaluated. The particle sizes of the samples under each condition before and after storage were tested.

[0204] The test results are shown in Table 5.

[0205] Table 5

[0206]

[0207] After 3 months of stability testing, the shampoos using Examples 1 to 8 and Comparative Examples 1 to 19 did not show stratification, while the shampoos using Comparative Example 20 and Comparative Example 21 showed stratification. This indicates that appropriate ball milling pretreatment of selenium disulfide can effectively improve the stability of the shampoo prepared from the composition of the present invention.

[0208] Test Example 3

[0209] In this test example, the particle size distribution of selenium disulfide in the shampoos of Application Examples 1 to 8 and Application Comparative Examples 1 to 21 was tested according to the test method described in GB / T 19077-2016 Particle Size Distribution Laser Diffraction Method.

[0210] The particle size distribution of selenium disulfide in the shampoos of Application Examples 1 to 8 is within 10 μm, D 90 The selenium disulfide in the shampoo of Example 1 is D 10 2.011μm, D 90 The selenium disulfide in the shampoo of Example 2 is 9.122 μm;10 2.323 μm, D 90 The selenium disulfide in the shampoo of Comparative Example 20 is 9.331 μm; 10 3.121μm, D 90 The selenium disulfide in the shampoo of Application Example 21 is 15.142 μm; 10 3.822μm, D 90 14.423μm;

[0211] The present invention controls the particle size distribution of selenium disulfide in selenium disulfide shampoo by ball milling technology. The particle size of selenium disulfide in the shampoo of comparative example 20 and comparative example 21 is larger, which is more likely to cause the risk of aggregation, resulting in excessive concentration of selenium disulfide in the shampoo.

[0212] Test Example 4

[0213] This test example tests the anti-dandruff effects of the shampoos of Application Examples 1 to 8 and Application Comparative Examples 1 to 19.

[0214] The anti-dandruff effect was tested and evaluated by referring to the carrier immersion antibacterial test in the "Test Method for Anti-dandruff Efficacy of Anti-dandruff Products" TGDCA010-2022 (official version).

[0215] (1) Resuspend the activated Malassezia furfur with PBS to a bacterial density of 5×10 6 CFU / mL~5*×10 7 CFU / mL bacterial suspension. Pipette 10 μL of bacterial suspension onto a sterilized carrier and air dry at room temperature to obtain a bacterial-infected carrier.

[0216] (2) Weigh the sample to be tested at 5 g / piece into a sterile plate, place it in a (20±1)℃ water bath for 5 min, use sterile tweezers to take the infected carrier, immerse the carrier completely in the sample, and start timing immediately. After the infected carrier and the sample interact for the specified time, take the infected carrier and add 5.0 mL PBS to a test tube or homogenizing bag, shake it thoroughly, wash off the test bacteria, and mix well. According to the concentration of the bacterial solution, use PBS to dilute it 10 times, select the appropriate dilution, take 1.0 mL of the sample solution, put it into a sterile plate, inoculate 2 plates in total, pour in Leeming and Notman culture medium, turn the plate over after solidification, place it at (28±2)℃, and count after 7 days of incubation. Use PBS buffer instead of the sample as the control group, and operate according to the above steps.

[0217] The number of recovered colonies (C, in CFU / piece) and the inhibition rate (Y, in %) of each carrier were calculated.

[0218] C = [(N1+N2) / 2]*F*V;

[0219] Where: N is the number of colonies counted on each dish, in CFU; F is the dilution factor; V is the initial recovery solution volume, in mL.

[0220] Y = (C0-C1) / C0*100%;

[0221] In the formula: C0 is the average number of colonies recovered from the carrier after the control group, and the unit is CFU / piece; C1 is the average number of colonies recovered from the carrier after the test group, and the unit is CFU / piece.

[0222] The test results are shown in Table 6.

[0223] Table 6

[0224]

[0225]

[0226] The antibacterial rate of the shampoo of Example 1 to 8 is above 97%. The absence or replacement of any one of selenium disulfide, decanediol, climbazole, dipotassium glycyrrhizinate and tea seed extract will lead to poor antibacterial effect.

[0227] This indicates that selenium disulfide, decanediol, climbazole, dipotassium glycyrrhizinate, and tea seed extract in the long-acting oil-controlling and anti-dandruff composition of the present invention can synergistically inhibit Malassezia furfur and improve the antibacterial and anti-dandruff effects.

[0228] Test Example 5

[0229] This test example tests the use effects of the shampoos of Application Examples 1 to 8 and Comparative Examples 1 to 21.

[0230] 300 healthy volunteers who have oily scalp and dandruff problems and meet the relevant test requirements were recruited and randomly divided into groups with 10 volunteers in each group. They used the shampoos of application examples 1 to 8, application comparison examples 1 to 21, and a commercially available oil-control and anti-dandruff shampoo for 4 weeks, three times a week. Do not wash your hair 3 days before the scalp oil test. Use Sebumeter SM815 skin oil test probe (Courage & Khazaka, Germany) to test the scalp oil content. The scalp oil is tested before the corresponding test sample is used, recorded as A0; 3 days after the last use of the test sample, the scalp oil content of the same area of ​​the subject's scalp is tested, recorded as A1. The measurement was repeated three times each time, and the results were averaged. And calculate the percentage reduction of scalp oil content after 4 weeks of use of the product. The calculation formula for the percentage reduction of scalp oil content is as follows:

[0231] Scalp oil content reduction percentage (%) = (A0-A1) / A0*100%.

[0232] The subjects were scored based on their experience and the results of the use were reviewed. The scoring standard was 10 points. The scoring dimensions included: the improvement of oil control, dandruff improvement, comfort score, overall evaluation, and dandruff improvement after continuous use of the test sample for four weeks, and one month after stopping use.

[0233] Improvement in oil control, improvement in dandruff, and improvement in dandruff one month after discontinuation of use: 0 for no improvement, 10 for significant improvement; the larger the number, the greater the improvement. Comfort rating: 0 for very uncomfortable, 10 for comfortable; the larger the number, the more comfortable. Overall evaluation rating: 0 for very dissatisfied, 10 for satisfied, the larger the number, the more satisfied.

[0234] The test results are shown in Table 7.

[0235] Table 7

[0236]

[0237]

[0238] Compared with the shampoos of comparative examples 1 to 21 and commercially available oil-control and anti-dandruff shampoos, the shampoos of examples 1 to 8 have significantly better effects in oil control, anti-dandruff, and comfort of use, and are generally favored by testers. Omitting or replacing any one or any two of selenium disulfide, decanediol, climbazole, dipotassium glycyrrhizinate, and tea seed extract will lead to poor oil control, anti-dandruff and other effects.

[0239] In summary, the selenium disulfide, decanediol, climbazole, dipotassium glycyrrhizinate, and tea seed extract in the long-acting oil-control and anti-dandruff composition of the present invention have significant synergistic effects in oil control, dandruff removal, soothing, and improving comfort of use; after one month of discontinuation of use, the anti-dandruff effect still exists, and dandruff is not easy to recur.

[0240] The embodiments of the present invention are described in detail above in conjunction with the embodiments, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge scope of ordinary technicians in the relevant technical field without departing from the purpose of the present invention.

Claims

1. A composition, characterized in that include: Selenium disulfide, decanediol, climbazole, dipotassium glycyrrhizinate, tea seed extract; The selenium disulfide is ground.

2. The composition according to claim 1, characterized in that In parts by mass, the composition comprises: Preferably, the composition comprises, by weight: Preferably, the composition comprises, by weight:

3. The composition according to claim 1, characterized in that The D 90 2~10μm; And / or, the grinding process includes at least one of ball milling and sand milling.

4. The method for preparing the composition according to any one of claims 1 to 3, characterized in that: The following steps are involved: The composition is obtained by mixing the components.

5. A cosmetic, characterized in that: The cosmetic comprises the composition according to any one of claims 1 to 3, and cosmetically acceptable auxiliary materials; preferably, the cosmetic contains 0.01% to 40% of the composition by mass.

6. The cosmetic according to claim 5, characterized in that: The auxiliary materials include at least one of a conditioning agent, a chelating agent, a surfactant, an excipient, a thickener, a suspending agent, a flavor, a preservative and a pH regulator.

7. The cosmetic according to claim 6, characterized in that: If any, the cosmetic contains 0.05% to 0.8% of the conditioner by mass; if any, the cosmetic contains 0.05% to 0.5% of the chelating agent by mass; if any, the cosmetic contains 7% to 20% of the surfactant by mass; if any, the cosmetic contains 0.5% to 5% of the thickener by mass; if any, the cosmetic contains 0.1% to 2% of the suspending agent by mass; if any, the cosmetic contains 0.3% to 1.5% of the flavor by mass; if any, the cosmetic contains 0.05% to 0.3% of the preservative by mass; if any, the cosmetic contains 0.05% to 0.3% of the pH adjuster by mass.

8. The cosmetic according to claim 6, characterized in that: The conditioning agent includes at least one of polyquaternium-10, polyquaternium-7, and guar hydroxypropyltrimonium chloride; And / or, the chelating agent includes at least one of disodium EDTA, etidronate, and tetrasodium EDTA; and / or, the surfactant includes at least one of sodium laureth sulfate, ammonium laureth sulfate, cocamidopropyl betaine, sodium cocoyl isethionate, sodium methyl cocoyl taurate, sodium cocoyl methyl taurate, and disodium lauryl sulfosuccinate; And / or, the thickener includes at least one of cocamide MEA and carbomer; And / or, the suspending agent comprises at least one of coconut trihydroxystearin, carbomer, and hydrogenated castor oil; And / or, the preservative includes at least one of phenoxyethanol, sodium benzoate, potassium sorbate, and p-anisic acid; And / or, the pH adjuster includes at least one of citric acid, sodium citrate, lactic acid, and aminomethyl propanol.

9. Use of the composition according to any one of claims 1 to 3 in the preparation of a product having an inhibitory effect on Malassezia furfur.

10. Use of the composition according to any one of claims 1 to 3 in the preparation of cosmetics.

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