Spray liquid capable of clearing heat from throat

Abstract

The invention provides spray liquid for clearing heat from throat. The spray liquid for clearing heat from throat comprises the following components in percentage by weight: 3%-8% of towel gourd extract, 2%-5% of litchi extract and 87%-95% of preserving fluid. The throat clearing spray liquid disclosed by the invention has the effect of relieving pharyngitis. After the lychee extract and the towel gourd extract are compounded, the anti-inflammatory effect of the towel gourd extract is remarkably enhanced, and the lychee extract and the towel gourd extract have a potential good clinical application prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of development of oral care products, and in particular relates to a throat clearing spray. Background Art

[0002] Pharyngitis is a common pharyngeal disease, characterized by inflammation of the pharyngeal mucosa and lymphoid tissue, which is recurrent, cyclical, and difficult to cure. After pharyngitis occurs, the pharynx may produce discomfort symptoms such as foreign body sensation, burning, irritation, and pain, which affect the patient's speech and eating. At present, most clinical medications for pharyngitis are Western medicines, which have slow effects and side effects; the medication method is mostly application or smearing, which is inconvenient to use.

[0003] The applicant of the present invention uses two medicinal and edible plants, loofah and litchi, as raw materials to create a throat-clearing and throat-relief spray that is easy to use, quick in effect, and has no toxic side effects, which is of great significance for the relief of pharyngitis. The document "Li Li, Lv Yingnian, Wang Tianji, et al. A new use of an apple loofah juice alcohol precipitate extract in throat clearing and throat moistening [P]. Guangdong Province: CN202211682152.5, 2024-11-19." discloses an apple loofah juice alcohol precipitate extract for treating or relieving symptoms of excessive pharyngeal phlegm, pharyngeal redness and swelling, pharyngeal pain, pharyngeal itching, and aphonia and hoarseness. The document "Kou Junping, Zhuang Shufei, Tang Xinjuan, et al. Research on the anti-inflammatory and anti-allergic effects of loofah vine alcohol extract [J]. Journal of China Pharmaceutical University, 2001, (04): 55-58." discloses that the loofah vine alcohol extract has anti-inflammatory and anti-allergic effects. The loofah extract and its anti-inflammatory efficacy in the above-mentioned disclosed patents are prior art, and their effects in the relief of pharyngitis need to be further improved. The present invention uses a sponge gourd extract and a litchi extract to obtain a throat-clearing and throat-relief spray liquid for the relief of pharyngitis, showing a significant and unexpected technical effect that is superior to the prior art. At the same time, the spray liquid application method has better convenience and compliance than the traditional application or smearing method, and has a high potential economic value. Summary of the invention

[0004] The present invention aims to provide a throat clearing spray to solve the problems raised in the above-mentioned background technology.

[0005] The present invention provides a throat-clearing spray liquid, which is composed of 3% to 8% of a loofah extract, 2% to 5% of a litchi extract, and 87% to 95% of a preservative solution in percentage by weight; The sponge gourd extract is a concentrated solution of the product extracted from fresh sponge gourd plants by water extraction and ethanol extraction; The litchi extract is a concentrated solution of a mixture of freshly squeezed litchi fruit juice and an ethanol extract of the solid residue remaining after squeezing the juice; The mass percentage composition of the preservation solution is: 25% anhydrous ethanol, 5% antioxidant, 5% sweetener, and 65% sterile water; The antioxidant is one of vitamin C or tea polyphenols or a combination of the two; The sweetener is xylitol or menthol, or a combination of the two.

[0006] The benefits of the present invention are: 1. The present invention provides a throat-clearing and throat-relief spray liquid with the effect of relieving pharyngitis, wherein the effective ingredients are loofah extract and litchi extract, both of which are medicinal and edible plants, and are environmentally friendly, safe, and non-toxic and side-effect-free.

[0007] 2. The throat-clearing and throat-relief spray of the present invention has a significant effect on relieving pharyngitis, is superior to the existing preparations with loofah extract as the effective ingredient, and has good application and economic benefit prospects.

[0008] 3. Experiments have verified that the sponge gourd extract, litchi extract and preservation solution described in the present invention are not simply mixed and superimposed with each other, but are creative technologies that produce unexpected technical effects that are significantly better than the existing technologies under specific proportions, and have obvious novelty, creativity and practicality. DETAILED DESCRIPTION

[0009] The principles and features of the present invention are described below in conjunction with examples. The examples are only used to explain the present invention and are not used to limit the scope of the present invention.

[0010] Example 1. A throat-clearing spray liquid, the mass percentage of which is: 3% of loofah extract, 2% of litchi extract, and 95% of preservation solution; The sponge gourd extract is a concentrated solution of the product extracted from fresh sponge gourd plants by water extraction and ethanol extraction; The litchi extract is a concentrated solution of a mixture of freshly squeezed litchi fruit juice and an ethanol extract of the solid residue remaining after squeezing the juice; The mass percentage composition of the preservation solution is: 25% anhydrous ethanol, 5% antioxidant, 5% sweetener, and 65% sterile water; The antioxidant is tea polyphenols; The sweetener is xylitol.

[0011] Example 2. A throat-clearing spray liquid, the mass percentage of which is: 8% of loofah extract, 5% of litchi extract, and 87% of preservation solution; The sponge gourd extract is a concentrated solution of the product extracted from fresh sponge gourd plants by water extraction and ethanol extraction; The litchi extract is a concentrated solution of a mixture of freshly squeezed litchi fruit juice and an ethanol extract of the solid residue remaining after squeezing the juice; The mass percentage composition of the preservation solution is: 25% anhydrous ethanol, 5% antioxidant, 5% sweetener, and 65% sterile water; The antioxidant is a mixture of vitamin C and tea polyphenols in equal weight ratio; The sweetener is menthol.

[0012] Example 3. A throat-clearing spray liquid, the mass percentage of which is: 5% of loofah extract, 3% of litchi extract, and 92% of preservative solution; The sponge gourd extract is a concentrated solution of the product extracted from fresh sponge gourd plants by water extraction and ethanol extraction; The litchi extract is a concentrated solution of a mixture of freshly squeezed litchi fruit juice and an ethanol extract of the solid residue remaining after squeezing the juice; The mass percentage composition of the preservation solution is: 25% anhydrous ethanol, 5% antioxidant, 5% sweetener, and 65% sterile water; The antioxidant is vitamin C; The sweetener is a mixture of xylitol and menthol in an equal weight ratio.

[0013] Comparative Example 1. Referring to Example 1, the sponge gourd extract was replaced with litchi extract, and the remaining technical features were the same as those in Example 1, that is, a comparative example without sponge gourd extract was prepared.

[0014] Comparative Example 2. Referring to Example 2, the litchi extract was replaced with the loofah extract. The remaining technical features were the same as those of Example 2, that is, a comparative example without litchi extract was prepared.

[0015] Comparative Example 3. Referring to Example 3, the preservation solution was replaced with sterile water, and the remaining technical features were the same as those of Example 3, that is, a comparative example without preservation solution was prepared.

[0016] Experiment. 70 patients (age range 18-65 years old) suffering from pharyngitis between February 2024 and October 2024 were selected as test subjects for a pharyngitis spray relief test. Set up Example 1-3 groups, Comparative Example 1-3 groups, and Control 1 group, a total of 7 groups of treatment, and each group of treatment randomly assigned 10 patients. Patients in the control group were sprayed with normal saline, and patients in the experimental group were sprayed with the throat-clearing spray prepared by the group scheme. The treatment cycle is 10 days, during which the affected area is sprayed once in the morning, noon, and evening every day, and water and food are prohibited within 30 minutes after spraying. During the treatment period, each volunteer patient was video-visited on time every day to observe and record the healing of the affected area. The wound healing area was greater than or equal to 90% and the pain disappeared, which was recorded as a cured case. The cure rate calculation formula is: , the results are shown in Table 1:

[0017] As shown in Table 1, the recovery period of patients in Examples 1-3 and Comparative Examples 2 and 3 were significantly ( P＜ 0.05 ) shortened, proving that each group of the embodiment and the comparative examples 2 and 3 groups all had a certain effect on relieving pharyngitis. Compared with the control group and the comparative examples 1-3 groups, the embodiment 1-3 groups had extremely significant ( P＜0.01 ) is shortened, proving that the loofah extract, litchi extract, and preservation solution in the throat-clearing and throat-relief spray of the present invention all play an important role in alleviating pharyngitis, and none of them is dispensable, and they are irreplaceable with each other. This experiment proves that the loofah extract, litchi extract, and preservation solution described in the present invention are not simply mixed and superimposed, but are a specific combination based on the premise of significantly better effects than those produced by a single substance. That is, the throat-clearing and throat-relief spray of the present invention does not rely on the efficacy of a single substance or the simple superposition of the efficacy of a single substance, but is a specific substance that produces an unexpected technical effect that is significantly better than the prior art under a specific combination.

[0018] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A throat clearing spray, characterized in that: The mass percentage composition of the spray liquid is: 3% to 8% of loofah extract, 2% to 5% of litchi extract, and 87% to 95% of preservation solution.

2. A throat clearing spray according to claim 1, characterized in that: The preservation solution is composed of anhydrous ethanol, antioxidant, sweetener and sterile water.

3. Use of the throat clearing spray as claimed in claim 1 in relieving pharyngitis.

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