Whitening type oral soluble film and preparation process and film making machine thereof

By combining specific whitening components and film forming systems in the oral dissolving film, the deficiencies in the dissolution performance and mechanical properties of the whitening oral dissolving film are solved, and the whitening effect is achieved, and the uniform components are ensured through the design of the film making machine Distribution and drug load control.

CN119302929APending Publication Date: 2025-01-14KOREA H&L BIOTECH CO LTD
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Patent Information

Application Number
CN202411226616.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-03
Publication Date
2025-01-14

AI Technical Summary

Technical Problem

The existing oral-soluble membranes are mainly used for medication rather than whitening effects. They lack research on whitening ingredients, and their dissolution and mechanical properties in the oral cavity are insufficient.

Method used

Develop a whitening oral-soluble membrane, using efficacy reagents including L-glutathione yeast extract, Tremella extract, Prulandosaccharide, vitamin C, white tomato extract and L-cysteine ​​salt, combined with The film forming system of polymer film forming materials, dextrins, auxiliary materials and phosphate buffer solution is prepared by spraying and drying processes of the film making machine, and the hydrophilic and lipophilic properties of lecithin are used to improve the dispersion uniformity and solubility of components. .

Benefits of technology

The whitening components are effectively exerted through the oral membrane dissolving principle, and good mechanical properties and rapid solubility are obtained. At the same time, through the design of the membrane-making machine, the uniform distribution of components and the control of drug loading are ensured, which is suitable for different widths. Base film.

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Abstract

The invention relates to the field of oral soluble films, and particularly discloses a whitening type oral soluble film, a preparation technology thereof and a film making machine, the whitening type oral soluble film comprises a base film and slurry forming the film on the base film, and the slurry is composed of raw materials including an effect reagent, a polymer film forming material, dextrin, an auxiliary material and a phosphate buffer solution; the efficacy reagent is prepared from the following components: 42 to 44 percent of L-glutathione yeast extract, 15 to 17 percent of tremella fuciformis extract, 12 to 14 percent of pullulan, 7 to 9 percent of water, 6 to 9 percent of vitamin C, 6 to 7 percent of white tomato extract and 3 to 5 percent of L-cysteine salt; the mass ratio of the efficacy reagent to the polymer film-forming material to the dextrin to the auxiliary material is 1: (10-15): (3-5): (5-6); the total mass of the functional reagent, the polymer film-forming material, the dextrin and the auxiliary material is 15-50% of the phosphate buffer solution. The oral soluble film is based on the five core whitening components, and the film body not only has good strength and toughness, but also can be rapidly dissolved in the mouth.
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Citation Information

Cited By

  • Compound oral film and preparation method thereof

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