Traditional Chinese medicine composition and application thereof in preparation of medicine for preventing and / or treating liver injury
The traditional Chinese medicine composition formed by using Chinese medicine compositions such as wolfberry, mulberry, black plum, etc., especially the addition of white lentils, hawthorn and mint, effectively preventing and treating liver damage, and solving the problem of poor treatment effect of liver damage in the prior art. , significantly improves the protection effect of the liver.
Patent Information
- Application Number
- CN202411519891.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-29
- Publication Date
- 2025-01-14
AI Technical Summary
The existing technology is difficult to effectively prevent and treat liver damage, the pathogenesis of liver damage is complex, and the existing drugs have limited multi-stage protection effect on liver damage.
Provided is a traditional Chinese medicine composition, which comprises wolfberry, mulberry, black plum, tangerine peel, lotus seeds, polygonatum, malt, amomum villos and raw licorice, preferably white lentils, hawthorn and mint are added, and the preparation of a drug through an extract or an extract is made into a medicine for use in the Prevent and treat liver damage.
This traditional Chinese medicine composition significantly improves the prevention and treatment effect of liver injury, improves antioxidant ability, inhibits hepatocyte apoptosis, regulates liver metabolism and improves inflammatory response through synergistic effects, and has good liver protection function.
Smart Images
Figure BDA0005107751290000061
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition and application thereof in preparing a medicine for preventing and / or treating liver damage. Background Art
[0002] The liver is a key organ of the human body. Liver injury refers to the pathological and functional changes of the liver caused by various reasons. Long-term damage can develop into liver fibrosis, cirrhosis, liver failure, liver cancer, etc. It is reported that about 3.5% of deaths worldwide are directly related to liver injury, and the incidence rate is high, which seriously threatens human health. According to its cause, it can be divided into drug-induced liver injury, chemical liver injury, immune liver injury, alcoholic liver injury, etc. The pathogenesis of liver injury is complex. At present, it is mostly focused on alcohol, chemicals and other stimuli inducing liver cell inflammation causing repeated "secondary strikes", toxic bile acid accumulation in the bile duct activating oxidative stress, inflammatory response leading to bile duct obstruction, and excessive drug intake destroying the liver cell microenvironment inducing oxidative stress to cause abnormal liver metabolism.
[0003] Traditional Chinese medicine has unique advantages and potential in liver protection. It has a wide range of indications and the overall regulation characteristics of multiple components, multiple targets and multiple links. Many drugs and active ingredients have been proven to have liver protection effects and can be effective at multiple stages of liver damage. The main mechanisms of action include improving liver antioxidant capacity, inhibiting liver cell apoptosis, regulating liver cell autophagy, regulating liver metabolism, and improving liver inflammation. According to traditional Chinese medicine, the causes of liver disease can be divided into internal and external causes. The internal cause is the seven emotions, which are mostly caused by emotions or irregular lifestyles. The external cause is mainly the invasion of the six evils. Liver damage can be classified into the categories of "flank pain", "jaundice", "accumulation" and "bloating" in traditional Chinese medicine. According to traditional Chinese medicine, toxic evils are deeply hidden in the liver, which damage liver blood, liver yin and liver over time. The occurrence of liver disease is mainly based on the main contradiction of deficiency of righteous qi. The treatments of soothing the liver and regulating qi, clearing away dampness and heat in the liver and gallbladder, replenishing qi and activating blood circulation, and nourishing yin and tonifying the kidney are common treatments for liver disease.
[0004] In summary, providing a traditional Chinese medicine that has the function of preventing and / or treating liver damage has the application value of traditional Chinese medicine. Summary of the invention
[0005] In order to overcome at least one technical problem existing in the prior art, the present invention provides a traditional Chinese medicine composition and its use in preparing a medicament for preventing and / or treating liver damage.
[0006] The present invention first provides a Chinese medicine composition, characterized in that it comprises the following Chinese medicine components: wolfberry
[0007] son, mulberry
[0008] Mulberry, black plum, tangerine peel, lotus seed, polygonatum, malt, amomum and raw licorice.
[0009] The inventor found in the research that the ingredients include wolfberry, mulberry, black plum, tangerine peel, lotus seed, polygonatum, malt, and amomum villosum.
[0010] And a Chinese medicinal composition of raw licorice, which has a good effect of preventing and / or treating liver damage.
[0011] Preferably, the Chinese medicine composition comprises the following Chinese medicine components in parts by weight:
[0012] 5-40 parts of wolfberry, 5-30 parts of mulberry, 5-30 parts of black plum, 10-30 parts of tangerine peel, 5-30 parts of lotus seeds, 5-30 parts of polygonatum, 5-60 parts of malt, 5-20 parts of amomum, and 5-20 parts of raw licorice.
[0013] Further preferably, the Chinese medicine composition comprises the following Chinese medicine components in parts by weight:
[0014] 10-30 parts of wolfberry, 5-20 parts of mulberry, 5-20 parts of black plum, 10-30 parts of tangerine peel, 5-20 parts of lotus seeds, 10-30 parts of polygonatum, 10-40 parts of malt, 5-20 parts of amomum, and 5-20 parts of raw licorice.
[0015] Most preferably, the Chinese medicine composition comprises the following Chinese medicine components in parts by weight:
[0016] 15 parts of wolfberry, 10 parts of mulberry, 10 parts of black plum, 15 parts of dried orange peel, 10 parts of lotus seeds, 15 parts of polygonatum, 30 parts of malt, 10 parts of amomum, 10 parts of raw liquorice;
[0017] Or, 10 parts of wolfberry, 5 parts of mulberry, 5 parts of black plum, 10 parts of dried orange peel, 5 parts of lotus seeds, 10 parts of polygonatum, 20 parts of malt, 5 parts of amomum, and 5 parts of raw liquorice;
[0018] Or, 20 parts of wolfberries, 15 parts of mulberries, 15 parts of ebony plums, 20 parts of dried tangerine peels, 15 parts of lotus seeds, 20 parts of polygonatum, 60 parts of malt, 20 parts of amomum, and 20 parts of raw liquorice.
[0019] Further preferably, the Chinese medicine composition also contains white lentil flower, hawthorn and mint.
[0020] The inventors found in further research that the composition of the Chinese wolfberry, mulberry, black plum, tangerine peel, lotus seed, and yellow
[0021] Fine, wheat
[0022] White lentil flower, hawthorn and mint are further added to the traditional Chinese medicine composition of buds, amomum villosum and raw licorice, which can further significantly enhance the effect of the traditional Chinese medicine composition in preventing and / or treating liver damage; thus, the traditional Chinese medicine composition has a very excellent effect in preventing and / or treating liver damage.
[0023] The inventors also found in further research that in the Chinese medicine composition comprising wolfberry, mulberry, ebony, tangerine peel, lotus seed, polygonatum, malt, amomum and raw licorice, white lentil flower, hawthorn and mint must be further added simultaneously to further significantly improve the prevention and / or treatment of liver damage by the Chinese medicine composition; however, only adding a single white lentil flower, hawthorn or mint does not further significantly improve the prevention and / or treatment of liver damage by the Chinese medicine composition. In the Chinese medicine composition comprising wolfberry, mulberry, ebony, tangerine peel, lotus seed, polygonatum, malt, amomum and raw licorice, white lentil flower, hawthorn and mint are further added simultaneously to synergistically improve the prevention and / or treatment of liver damage by the composition.
[0024] More preferably, the Chinese medicine composition comprises the following Chinese medicine components in parts by weight:
[0025] 5-40 parts of wolfberry, 5-30 parts of mulberry, 5-30 parts of black plum, 5-30 parts of white hyacinth bean flower, 10-30 parts of tangerine peel, 5-30 parts of lotus seeds, 5-30 parts of polygonatum, 5-60 parts of malt, 5-20 parts of amomum, 5-20 parts of hawthorn, 5-20 parts of mint, and 5-20 parts of raw licorice.
[0026] Still more preferably, the Chinese medicine composition comprises the following Chinese medicine components in parts by weight:
[0027] 10-30 parts of wolfberry, 5-20 parts of mulberry, 5-20 parts of black plum, 5-20 parts of white hyacinth bean flower, 10-30 parts of tangerine peel, 5-20 parts of lotus seeds, 10-30 parts of polygonatum, 10-40 parts of malt, 5-20 parts of amomum, 5-20 parts of hawthorn, 5-20 parts of mint, and 5-20 parts of raw licorice.
[0028] Most preferably, the Chinese medicine composition is characterized by comprising the following Chinese medicine components in parts by weight:
[0029] 15 parts of wolfberry, 10 parts of mulberry, 10 parts of black plum, 10 parts of white hyacinth bean flower, 15 parts of dried orange peel, 10 parts of lotus seeds, 15 parts of polygonatum, 30 parts of malt, 10 parts of amomum, 10 parts of hawthorn, 10 parts of mint, 10 parts of raw liquorice;
[0030] Or, 10 parts of wolfberry, 5 parts of mulberry, 5 parts of black plum, 5 parts of white hyacinth bean flower, 10 parts of dried tangerine peel, 5 parts of lotus seeds, 10 parts of polygonatum, 20 parts of malt, 5 parts of amomum, 5 parts of hawthorn, 5 parts of mint, 5 parts of raw liquorice;
[0031] Or, 20 parts of wolfberries, 15 parts of mulberries, 15 parts of ebony, 15 parts of white hyacinthus flowers, 20 parts of dried tangerine peels, 15 parts of lotus seeds, 20 parts of polygonatum, 60 parts of malt, 20 parts of amomum, 20 parts of hawthorn, 20 parts of mint, and 20 parts of raw liquorice.
[0032] The present invention also provides a method for preparing a medicine for preventing and / or treating liver damage using the above-mentioned Chinese medicine composition.
[0033] Application in things.
[0034] Preferably, the medicine uses the extract or extract obtained by using the above-mentioned Chinese medicine composition as raw material as the active ingredient.
[0035] Preferably, the extract is prepared by the following method:
[0036] The Chinese medicine composition is extracted with a solvent to obtain an extract.
[0037] Preferably, the extract is prepared by the following method:
[0038] The Chinese medicine composition is extracted with a solvent to obtain an extract; the extract is concentrated and dried to obtain the extract.
[0039] Preferably, the solvent is water, alcohol or an aqueous solution of alcohol.
[0040] Preferably, the alcohol is ethanol or methanol.
[0041] Preferably, the extraction is performed by heating and boiling for 1 to 3 hours.
[0042] Preferably, the extraction refers to heating reflux extraction, and the extraction time is 1 to 3 hours.
[0043] Preferably, the weight amount of the solvent is 5 to 15 times the total weight of the Chinese medicine raw materials.
[0044] Preferably, the pharmaceutical dosage form is granules, capsules, pastes, tablets, concentrated pills or oral liquid preparations.
[0045] Beneficial effects: The present invention provides a new Chinese medicine composition. Studies have shown that the composition has
[0046] It has a good effect in preventing and / or treating liver damage; therefore, using it to prepare a drug for preventing and / or treating liver damage has important application value.
[0047] In the best formula of the present invention, wolfberry can nourish the yin of liver and kidney, and is a product that can nourish kidney essence, liver and blood. Modern research shows that it can protect liver and resist fatty liver, and is the "main medicine" of this prescription. Mulberry is sour and enters the liver, can nourish the yin of liver and kidney, and can produce body fluid and quench thirst; black plum is sour and enters the liver, and is compatible with licorice, "sour and sweet to transform yin", nourish yin, produce body fluid and quench thirst, and modern research shows that licorice has a liver-protecting effect; white lentil flower has the effect of detoxifying alcohol; tangerine peel strengthens the spleen and regulates qi, dries dampness and resolves phlegm, and helps the spleen and stomach to transport and transform; lotus seeds nourish the spleen and thicken the intestines and stomach, and the "Compendium of Materia Medica" calls it "a fruit of the spleen with a fragrant air"; Polygonatum odoratum is sweet and smooth, and can nourish kidney yin, nourish spleen yin, and benefit spleen qi; malt can help digestion and strengthen the stomach, and Amomum villosum can eliminate dampness and wake up the spleen, and promote qi and warm the middle. The ancients said: "It is an important medicine for waking up the spleen and regulating the stomach." Hawthorn is sour and enters the liver, and can digest food and resolve accumulation. Peppermint enters the liver meridian, can soothe the liver and promote qi, and is a "helper medicine". In summary, it has a very good effect in protecting against liver damage. DETAILED DESCRIPTION
[0048] The present invention is further explained below in conjunction with specific examples, but the examples do not limit the present invention in any form.
[0049] Example 1 Chinese medicine composition
[0050] Take 15 parts of wolfberry, 10 parts of mulberry, 10 parts of black plum, 15 parts of tangerine peel, 10 parts of lotus seeds, 15 parts of polygonatum, 30 parts of malt, 10 parts of amomum, and 10 parts of raw licorice, and mix them evenly to obtain the traditional Chinese medicine composition.
[0051] The "parts" in this embodiment and the following embodiments and comparative examples refer to "parts by weight".
[0052] Example 2 Chinese medicine composition
[0053] Take 10 parts of wolfberry, 5 parts of mulberry, 5 parts of black plum, 10 parts of tangerine peel, 5 parts of lotus seeds, 10 parts of polygonatum, 20 parts of malt, 5 parts of amomum, and 5 parts of raw licorice, and mix them evenly to obtain the traditional Chinese medicine composition.
[0054] Example 3 Chinese medicine composition
[0055] Take 20 parts of wolfberry, 15 parts of mulberry, 15 parts of black plum, 20 parts of tangerine peel, 15 parts of lotus seeds, 20 parts of polygonatum, 60 parts of malt, 20 parts of amomum, and 20 parts of raw licorice, mix them evenly to obtain the traditional Chinese medicine composition.
[0056] Example 4 Chinese medicine composition
[0057] Take 15 parts of wolfberry, 10 parts of mulberry, 10 parts of black plum, 10 parts of white hyacinth bean flower, 15 parts of tangerine peel, 10 parts of lotus seeds, 15 parts of polygonatum, 30 parts of malt, 10 parts of amomum, 10 parts of hawthorn, 10 parts of mint and 10 parts of raw licorice, mix them evenly to obtain the traditional Chinese medicine composition.
[0058] Example 5 Chinese medicine composition
[0059] Take 10 parts of wolfberry, 5 parts of mulberry, 5 parts of black plum, 5 parts of white hyacinth bean flower, 10 parts of tangerine peel, 5 parts of lotus seeds, 10 parts of polygonatum, 20 parts of malt, 5 parts of amomum, 5 parts of hawthorn, 5 parts of mint and 5 parts of raw licorice, mix them evenly to obtain the traditional Chinese medicine composition.
[0060] Example 6 Chinese medicine composition
[0061] Take 20 parts of wolfberry, 15 parts of mulberry, 15 parts of black plum, 15 parts of white hyacinth bean flower, 20 parts of tangerine peel, 15 parts of lotus seeds, 20 parts of polygonatum, 60 parts of malt, 20 parts of amomum, 20 parts of hawthorn, 20 parts of mint and 20 parts of raw licorice, mix them evenly to obtain the traditional Chinese medicine composition.
[0062] Comparative Example 1 Chinese medicine composition
[0063] Take 15 parts of wolfberry, 10 parts of mulberry, 10 parts of black plum, 10 parts of white hyacinth bean flower, 15 parts of tangerine peel, 10 parts of lotus seeds, 15 parts of polygonatum, 30 parts of malt, 10 parts of amomum, and 10 parts of raw licorice, and mix them evenly to obtain the traditional Chinese medicine composition.
[0064] Comparative Example 2 Chinese medicine composition
[0065] Take 15 parts of wolfberry, 10 parts of mulberry, 10 parts of black plum, 15 parts of tangerine peel, 10 parts of lotus seeds, 15 parts of polygonatum, 30 parts of malt, 10 parts of amomum, 10 parts of hawthorn and 10 parts of raw licorice, mix them evenly to obtain the traditional Chinese medicine composition.
[0066] Comparative Example 3 Chinese medicine composition
[0067] Take 15 parts of wolfberry, 10 parts of mulberry, 10 parts of black plum, 15 parts of tangerine peel, 10 parts of lotus seeds, 15 parts of polygonatum, 30 parts of malt, 10 parts of amomum, 10 parts of mint and 10 parts of raw licorice, mix them evenly to obtain the traditional Chinese medicine composition.
[0068] Experimental Example 1
[0069] SPF Kunming male mice were randomly divided into 7 groups, 12 mice in each group, namely normal group, model group, and drug groups 1 to 5. The mice in the drug group were gavaged with drugs according to their body weight (gavage dose was 20 mg / kg / day), once a day, and the normal group and model group were gavaged with an equal volume of normal saline every day for 5 consecutive days. Except for the normal group, each group was intraperitoneally injected with 0.12% CCl4 solution at a dose of 10 mL / kg 1 hour after the last gavage. The normal group was injected with an equal volume of peanut oil, fasted, and had free drinking water. 16 hours after the last injection of CCl4, the mice were anesthetized by intraperitoneal injection of 1% sodium pentobarbital 50 mg / kg, and the eyeballs were removed for blood collection. After the whole blood was placed at room temperature for 1 hour, it was centrifuged at 3000r / min for 10 minutes and the supernatant was taken for use. The contents of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in mouse serum were detected by an automatic biochemical analyzer. The test results are shown in Table 1.
[0070] The preparation methods of the drugs tested in drug groups 1 to 5 are as follows: take the Chinese medicine compositions described in Example 1, Example 4, and Comparative Examples 1 to 3 respectively, add 10 times the total weight of water of the Chinese medicine compositions respectively, and reflux extract at 100°C for 1 hour. After the extraction, the extract is concentrated and dried to obtain an extract; the extract obtained by extracting each Chinese medicine composition is taken as the test drug.
[0071] Table 1. Experimental results of Chinese medicine composition for preventing and / or treating liver injury
[0072]
[0073]
[0074] From the experimental results in Table 1, it can be seen that the ALT and AST contents of the mice in the model control group are significantly higher than those in the normal control group, which indicates that the modeling is successful.
[0075] From the experimental results in Table 1, it can be seen that the ALT and AST levels of mice in drug group 1 were significantly higher than those in
[0076] Below the model
[0077] This shows that the Chinese medicine composition of the present invention comprising wolfberry, mulberry, ebony, tangerine peel, lotus seed, polygonatum, malt, amomum and raw licorice has a good effect in preventing and / or treating liver injury.
[0078] It can be seen from the experimental results in Table 1 that the ALT content and AST content of mice in drug group 2 are further significantly lower than those in drug group 1; this shows that further adding white hyacinth bean flower, hawthorn and mint to the traditional Chinese medicine composition comprising wolfberry, mulberry, ebony, tangerine peel, lotus seed, polygonatum, malt, amomum and raw licorice can further significantly enhance the effect of the traditional Chinese medicine composition in preventing and / or treating liver damage.
[0079] From the experimental results in Table 1, it can be seen that the ALT content and AST content of the mice in drug groups 3 to 4 are lower than those in drug group 1, but the reduction is not large, and the reduction is much smaller than that in drug group 2; this shows that: in the Chinese medicine composition containing wolfberry, mulberry, ebony, tangerine peel, lotus seed, polygonatum, malt, amomum and raw licorice, white lentil flower, hawthorn and mint must be further added at the same time to further significantly improve the prevention and / or treatment of liver damage by the Chinese medicine composition; however, only adding a single white lentil flower, hawthorn or mint can not further significantly improve the prevention and / or treatment of liver damage by the Chinese medicine composition. In the Chinese medicine composition containing wolfberry, mulberry, ebony, tangerine peel, lotus seed, polygonatum, malt, amomum and raw licorice, white lentil flower, hawthorn and mint are further added at the same time to synergistically improve the prevention and / or treatment of liver damage by the composition.
Claims
1. A Chinese medicine composition, characterized in that: It contains the following Chinese medicinal ingredients: wolfberry, mulberry, black plum, tangerine peel, lotus seed, polygonatum, malt, amomum and raw licorice.
2. The Chinese medicine composition according to claim 1, characterized in that: Contains the following Chinese medicine components in parts by weight: 5-40 parts of wolfberry, 5-30 parts of mulberry, 5-30 parts of black plum, 10-30 parts of tangerine peel, 5-30 parts of lotus seeds, 5-30 parts of polygonatum, 5-60 parts of malt, 5-20 parts of amomum, and 5-20 parts of raw licorice.
3. The Chinese medicine composition according to claim 1, characterized in that Contains the following Chinese medicine components in parts by weight: 10-30 parts of wolfberry, 5-20 parts of mulberry, 5-20 parts of black plum, 10-30 parts of tangerine peel, 5-20 parts of lotus seeds, 10-30 parts of polygonatum, 10-40 parts of malt, 5-20 parts of amomum, and 5-20 parts of raw licorice.
4. The Chinese medicine composition according to claim 1, characterized in that: Contains the following Chinese medicine components in parts by weight: 15 parts of wolfberry, 10 parts of mulberry, 10 parts of black plum, 15 parts of dried orange peel, 10 parts of lotus seeds, 15 parts of polygonatum, 30 parts of malt, 10 parts of amomum, 10 parts of raw liquorice; Or, 10 parts of wolfberry, 5 parts of mulberry, 5 parts of black plum, 10 parts of dried orange peel, 5 parts of lotus seeds, 10 parts of polygonatum, 20 parts of malt, 5 parts of amomum, and 5 parts of raw liquorice; Or, 20 parts of wolfberries, 15 parts of mulberries, 15 parts of ebony plums, 20 parts of dried tangerine peels, 15 parts of lotus seeds, 20 parts of polygonatum, 60 parts of malt, 20 parts of amomum, and 20 parts of raw liquorice.
5. The Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition also contains white lentil flower, hawthorn and mint.
6. The Chinese medicine composition according to claim 5, characterized in that: Contains the following Chinese medicine components in parts by weight: 5-40 parts of wolfberry, 5-30 parts of mulberry, 5-30 parts of black plum, 5-30 parts of white hyacinth bean flower, 10-30 parts of tangerine peel, 5-30 parts of lotus seeds, 5-30 parts of polygonatum, 5-60 parts of malt, 5-20 parts of amomum, 5-20 parts of hawthorn, 5-20 parts of mint, and 5-20 parts of raw licorice.
7. The Chinese medicine composition according to claim 6, characterized in that: Contains the following Chinese medicine components in parts by weight: 10-30 parts of wolfberry, 5-20 parts of mulberry, 5-20 parts of black plum, 5-20 parts of white hyacinth bean flower, 10-30 parts of tangerine peel, 5-20 parts of lotus seeds, 10-30 parts of polygonatum, 10-40 parts of malt, 5-20 parts of amomum, 5-20 parts of hawthorn, 5-20 parts of mint, and 5-20 parts of raw licorice.
8. The Chinese medicine composition according to claim 6, characterized in that: Contains the following Chinese medicine components in parts by weight: 15 parts of wolfberry, 10 parts of mulberry, 10 parts of black plum, 10 parts of white hyacinth bean flower, 15 parts of dried orange peel, 10 parts of lotus seeds, 15 parts of polygonatum, 30 parts of malt, 10 parts of amomum, 10 parts of hawthorn, 10 parts of mint, 10 parts of raw liquorice; Or, 10 parts of wolfberry, 5 parts of mulberry, 5 parts of black plum, 5 parts of white hyacinth bean flower, 10 parts of dried tangerine peel, 5 parts of lotus seeds, 10 parts of polygonatum, 20 parts of malt, 5 parts of amomum, 5 parts of hawthorn, 5 parts of mint, 5 parts of raw liquorice; Or, 20 parts of wolfberries, 15 parts of mulberries, 15 parts of ebony, 15 parts of white hyacinthus flowers, 20 parts of dried tangerine peels, 15 parts of lotus seeds, 20 parts of polygonatum, 60 parts of malt, 20 parts of amomum, 20 parts of hawthorn, 20 parts of mint, and 20 parts of raw liquorice.
9. The Chinese medicine composition according to any one of claims 1 to 8 in the preparation of a medicine for preventing and / or treating liver damage Application in things.
10. The use according to claim 9, characterized in that: The medicine uses the extract or extract obtained by using the above-mentioned Chinese medicine composition as raw material as the effective ingredient.