Veterinary drug composition

Abstract

The invention discloses a veterinary medicine composition, which is prepared from the following medicines in parts by weight: 6 to 13 parts of penicillin, 0.5 to 1.4 parts of herba violae extract and 0.5 to 1.4 parts of fish extract. Through scientific proportioning of penicillin, a Corydalis delavayi Franch. Extract, a fish extract and other ingredients, the action mechanism of the penicillin is to inhibit synthesis of bacterial cell walls, so that the purpose of killing bacteria is achieved. The penicillin has a strong antibacterial effect on gram-positive bacteria, and especially has a good curative effect on most diseases caused by gram-positive bacteria, such as respiratory system infection, swine erysipelas, anthrax, septicemia and the like. Besides, penicillin also has a strong antibacterial effect on various spirochetes and actinomycetes, the delavay schefflera leaves can promote blood circulation, relieve swelling and pain, resist bacteria and kill viruses and enhance immunity, and meanwhile, the penicillin and the delavay schefflera leaves are matched with the fish extract, so that an effective treatment effect can be achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of veterinary medicines, in particular to a veterinary medicine composition. Background Art

[0002] Swine erysipelas is an acute febrile infectious disease caused by Erysipelothrix rhizogenes, with the main characteristics of high fever, acute septicemia, skin rash (subacute), chronic verrucous endocarditis and skin necrosis and multiple non-suppurative arthritis (chronic). At present, it is relatively rare in intensive pig farms, but it is still not completely controlled. The disease is distributed worldwide. Erysipelothrix rhizogenes is a Gram-positive bacterium with a clear tendency to form filaments. The bacteria are straight or slightly curved small rods with a size of 0.2-0.4 microns × 0.8-2.5 microns. The bacteria in the diseased material are arranged singly, in pairs or in clusters. They generally exist in clusters in white blood cells. In old broth cultures and in the endocardial warts of chronically sick pigs, they are mostly filamentous, sometimes very thin. The bacteria have strong resistance to natural environments such as salting, smoking, drying, corruption and sunlight.

[0003] The liver and spleen of dead pigs were kept at 4°C for 159 days, and the toxicity was still strong. Erysipelothrix rhizopus was isolated from the liver of dead pigs placed in the open air for 27 days, the dead pig carcasses buried 1.5 meters deep for 231 days, and pork treated with 12.5% ​​salt and refrigerated at 4°C for 148 days. It died quickly in general disinfectants such as 2% formalin, 1% bleaching powder, 1% sodium hydroxide or 5% carbonic acid. It has weak resistance to heat, and can be killed by broth culture at 50°C for 12 to 20 minutes and 70°C for 5 minutes. The bacteria are highly acid-resistant, and the acidity in the pig's stomach cannot kill it, so it can enter the intestine through the stomach.

[0004] The pathological changes of swine erysipelas are as follows: (1) Acute type: diffuse bleeding and small spots of bleeding occur in the gastric fundus and pyloric membrane; the entire intestine has varying degrees of catarrhal or hemorrhagic inflammation; the spleen is enlarged, showing a typical septic spleen; the kidneys are congested and swollen, known as "big purple kidneys"; the lymph nodes are congested and swollen, the cut surface is everted and juicy, and the lungs are congested and edematous; (2) Subacute type: the center of the congested plaque may appear pale due to edema compression. (3) Chronic type ① Endocarditis: Cauliflower-like growths can be seen in the heart of the mitral valve and aortic valve of defective endocarditis. ② Arthritis: joint swelling, with accumulation of serous and fibrinous exudates.

[0005] The main symptoms of swine erysipelas are: the incubation period of clinical symptoms is as short as 1 day and as long as 7 days. Acute type: This type is common, characterized by sudden outbreak, acute course and high mortality. Sick pigs are listless and have persistent high fever; they do not eat and vomit; their conjunctivae are congested; their feces are dry and hard with mucus. Piglets suffer from diarrhea in the later stage. The skin of the ears, neck and back is flushed and purple. Before death, there are irregular bright red patches in the armpits, thighs and abdomen, which fade and merge together after finger pressure. Death usually occurs within 3-4 days. The mortality rate is about 80%, and those who do not die turn into rash type or chronic type. When swine erysipelas occurs in suckling piglets and newly weaned piglets, the disease usually occurs suddenly, with neurological symptoms, convulsions, and death on the ground. The course of the disease usually does not exceed one day. Subacute type (rash type): The disease is relatively mild. In the first one or two days, clearly demarcated, round, quadrilateral, and hot rashes appear on different parts of the body, especially the chest, back, neck, and the whole body. They are commonly known as "fire marks" and fade when pressed. The rashes protrude 2-3 mm from the skin, and are about one to several centimeters in size, ranging from a few to dozens. After drying, brown scabs are formed. The sick pigs are thirsty, constipated, vomit, and have high body temperatures. After the rash occurs, the body temperature begins to drop, the disease is alleviated, and after several days or even more than ten days, the sick pigs recover on their own. There are also many sick pigs whose symptoms worsen during the onset of the disease and turn into septicemia and die. The course of the disease is about 1-2 weeks. Chronic type: It is transformed from acute or subacute type, and there are also primary types. Common ones include chronic arthritis, chronic endocarditis, and skin necrosis. The chronic arthritis type is mainly manifested by inflammatory swelling of the joints of the limbs (wrist and tarsal joints are more common than knee and hip joints), stiffness and pain in the sick legs. After that, the acute symptoms disappear, and the main symptoms are joint deformation, with one or two limbs being broken or lying on the ground. The sick pigs have a normal appetite, but grow slowly, are weak and emaciated. The course of the disease is several weeks or months. The main manifestations of chronic endocarditis are emaciation, anemia, general weakness, love to lie down, hate to walk, and if forced to walk, the behavior is slow and the whole body shakes. Auscultation of the heart has murmurs, accelerated and hyperactive heartbeats, irregular heartbeats, and rapid breathing. This type of sick pig cannot be cured, and usually dies suddenly due to cardiac paralysis. Ulcerative or cabbage-like warty polyptych endocarditis. Irregular heartbeat, difficulty breathing, anemia. The course of the disease is several weeks to several months. Chronic swine erysipelas sometimes forms skin necrosis. It often occurs on the back, shoulders, ears, hooves and tail. The local skin is swollen, raised, necrotic, black, dry and leathery. It gradually separates from the new tissue below, like a layer of shell. The necrotic area is sometimes very large, covering the entire back skin; sometimes it can occur in part of the ear shell, tail, tip, and hoof shell. After about 2 to 3 months, the necrotic skin falls off, leaving behind a hairless, light-colored scar and healing. If there is secondary infection, the condition will be complicated and the course of the disease will be prolonged.

[0006] At present, the drugs for preventing and treating swine erysipelas are penicillins (amoxicillin) and cephalosporins (ceftiofur sodium). However, the side effects of Western medicine are relatively large, and Western medicine only has obvious effects on a single disease or a class of diseases during treatment. For some diseases with more symptoms, the effect is not very obvious, and a lot of Western medicine is often required, which is expensive; however, due to the long-term use of antibiotics, there are drug residues and drug resistance, and the clinical effect is getting worse and worse. In addition, drug residues lead to export restrictions and endanger people's health, which greatly restricts the use of antibiotics.

[0007] Therefore, a veterinary drug composition is proposed to solve the current deficiencies. Summary of the invention

[0008] The technical problem to be solved by the present invention is to overcome the defects of the above-mentioned technology and provide a veterinary drug composition.

[0009] To solve the above technical problems, the technical solution provided by the present invention is a veterinary drug composition, which is prepared from the following drugs in weight ratio: 6 to 13 parts of penicillin, 0.5 to 1.4 parts of Lycium barometz leaf extract, and 0.5 to 1.4 parts of fish extract.

[0010] As an improvement, the drug is prepared from the following weight ratio: 10 parts of penicillin, 1 part of Lycium barometz leaf extract, and 1 part of fish extract.

[0011] As an improvement, the drug is prepared from the following drugs in the following weight ratio: 8 parts of penicillin, 0.8 parts of Lycium barometz leaf extract, and 1.1 parts of fish extract.

[0012] The advantages of the present invention compared with the prior art are:

[0013] Through the scientific proportion of penicillin, ground bone leaf extract, fish extract and other ingredients, the mechanism of action of penicillin is to inhibit the synthesis of bacterial cell walls, thereby achieving the purpose of killing bacteria. Penicillin has a strong antibacterial effect on Gram-positive bacteria, especially for most diseases caused by Gram-positive bacteria, such as respiratory system infections, swine erysipelas, anthrax, sepsis, etc., and has a good therapeutic effect. In addition, penicillin also has a strong antibacterial effect on various spirochetes and actinomycetes. Ground bone leaf can promote blood circulation, reduce swelling and relieve pain, fight bacteria and kill viruses, and enhance immunity. At the same time, combined with fish extract, it can play an effective therapeutic effect. DETAILED DESCRIPTION

[0014] The content of the present invention can be more easily understood by selecting the following detailed description of the preferred implementation method of the present invention and the embodiments included. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those of ordinary skill in the art to which the present invention belongs. When there is a conflict, the definition in this specification shall prevail.

[0015] As used herein, the term "prepared from" is synonymous with "comprising." As used herein, the terms "comprising," "including," "having," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises the listed elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

[0016] The conjunction "consisting of excludes any unspecified element, step, or component. If used in a claim, this phrase renders the claim closed-ended so that it does not include materials other than those described, except for conventional impurities associated therewith. When the phrase "consisting of" appears in a clause of the body of a claim rather than immediately following the subject matter, it limits only the elements described in that clause; other elements are not excluded from the claim as a whole.

[0017] When amount, concentration or other value or parameter is expressed as range, preferred range or a series of upper preferred value and lower preferred value limit range, this should be understood as specifically disclosing all ranges formed by any pairing of any range upper limit or preferred value and any range lower limit or preferred value, regardless of whether the range is disclosed separately. For example, when disclosing range "1 to 5", described range should be interpreted as including range "1 to 4", "1 to 3", "1 to 2", "1 to 2 and 4 to 5", "1 to 3 and 5" etc. When numerical range is described in this article, unless otherwise stated, the range is intended to include its end value and all integers and fractions within the range.

[0018] Singular forms include plural references unless the context clearly indicates otherwise. "Optional" or "either" means that the subsequently described event or incident may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

[0019] Approximate terms in the specification and claims are used to modify quantities, indicating that the present invention is not limited to the specific quantity, but also includes acceptable and modified parts close to the quantity without causing changes in the relevant basic functions. Accordingly, the use of "about", "approximately", etc. to modify a numerical value means that the present invention is not limited to the exact numerical value. In some examples, the approximate terms may correspond to the accuracy of the instrument for measuring the numerical value. In the specification and claims of this application, range limitations can be combined and / or interchanged, and if not otherwise stated, these ranges include all subranges contained therein.

[0020] In addition, the indefinite articles "a" and "an" before the elements or components of the present invention have no restrictions on the quantity requirements (i.e. the number of occurrences) of the elements or components. Therefore, "a" or "an" should be interpreted as including one or at least one, and the elements or components in the singular form also include the plural form, unless the number is obviously intended to be in the singular form.

[0021] "Polymer" means a polymeric compound prepared by polymerizing monomers of the same or different types. The general term "polymer" includes the terms "homopolymer", "copolymer", "terpolymer" and "interpolymer". "Interpolymer" means a polymer prepared by polymerizing at least two different monomers. The general term "interpolymer" includes the term "copolymer" (which is generally used to refer to a polymer prepared from two different monomers) and the term "terpolymer" (which is generally used to refer to a polymer prepared from three different monomers). It also includes polymers made by polymerizing more monomers. "Blend" means a polymer formed by mixing two or more polymers together by physical or chemical methods.

[0022] In addition, any methods and materials similar or equivalent to those described herein can be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and cannot limit the content of this application.

[0023] The experimental methods in the following examples are conventional methods unless otherwise specified; the test materials and test strains used in the following examples are purchased from commercial channels unless otherwise specified.

[0024] Embodiment 1

[0025] A veterinary drug composition is prepared from the following drugs in the following weight ratio: 6 parts of penicillin, 0.5 parts of Lycium barometz leaf extract and 0.5 parts of fish extract.

[0026] Through the scientific proportion of penicillin, ground bone leaf extract, fish extract and other ingredients, the mechanism of action of penicillin is to inhibit the synthesis of bacterial cell walls, thereby achieving the purpose of killing bacteria. Penicillin has a strong antibacterial effect on Gram-positive bacteria, especially for most diseases caused by Gram-positive bacteria, such as respiratory system infections, swine erysipelas, anthrax, sepsis, etc., and has a good therapeutic effect. In addition, penicillin also has a strong antibacterial effect on various spirochetes and actinomycetes. Ground bone leaf can promote blood circulation, reduce swelling and relieve pain, fight bacteria and kill viruses, and enhance immunity. At the same time, combined with fish extract, it can play an effective therapeutic effect.

[0027] Embodiment 2

[0028] A veterinary drug composition is prepared from the following drugs in the following weight ratio: 10 parts of penicillin, 1 part of Lycium barometz leaf extract and 1 part of fish extract.

[0029] Through the scientific proportion of penicillin, ground bone leaf extract, fish extract and other ingredients, the mechanism of action of penicillin is to inhibit the synthesis of bacterial cell walls, thereby achieving the purpose of killing bacteria. Penicillin has a strong antibacterial effect on Gram-positive bacteria, especially for most diseases caused by Gram-positive bacteria, such as respiratory system infections, swine erysipelas, anthrax, sepsis, etc., and has a good therapeutic effect. In addition, penicillin also has a strong antibacterial effect on various spirochetes and actinomycetes. Ground bone leaf can promote blood circulation, reduce swelling and relieve pain, fight bacteria and kill viruses, and enhance immunity. At the same time, combined with fish extract, it can play an effective therapeutic effect.

[0030] Embodiment 3

[0031] A veterinary drug composition is prepared from the following drugs in the following weight ratio: 8 parts of penicillin, 0.8 parts of Lycium barometz leaf extract, and 1.1 parts of fish extract.

[0032] Through the scientific proportion of penicillin, ground bone leaf extract, fish extract and other ingredients, the mechanism of action of penicillin is to inhibit the synthesis of bacterial cell walls, thereby achieving the purpose of killing bacteria. Penicillin has a strong antibacterial effect on Gram-positive bacteria, especially for most diseases caused by Gram-positive bacteria, such as respiratory system infections, swine erysipelas, anthrax, sepsis, etc., and has a good therapeutic effect. In addition, penicillin also has a strong antibacterial effect on various spirochetes and actinomycetes. Ground bone leaf can promote blood circulation, reduce swelling and relieve pain, fight bacteria and kill viruses, and enhance immunity. At the same time, combined with fish extract, it can play an effective therapeutic effect.

[0033] Embodiment 4

[0034] A veterinary drug composition is prepared from the following drugs in the following weight ratio: 13 parts of penicillin, 1.4 parts of Lycium barometz leaf extract, and 1.4 parts of fish extract.

[0035] Through the scientific proportion of penicillin, ground bone leaf extract, fish extract and other ingredients, the mechanism of action of penicillin is to inhibit the synthesis of bacterial cell walls, thereby achieving the purpose of killing bacteria. Penicillin has a strong antibacterial effect on Gram-positive bacteria, especially for most diseases caused by Gram-positive bacteria, such as respiratory system infections, swine erysipelas, anthrax, sepsis, etc., and has a good therapeutic effect. In addition, penicillin also has a strong antibacterial effect on various spirochetes and actinomycetes. Ground bone leaf can promote blood circulation, reduce swelling and relieve pain, fight bacteria and kill viruses, and enhance immunity. At the same time, combined with fish extract, it can play an effective therapeutic effect.

[0036] The present invention and its implementation methods are described above, but such description is not restrictive, and what is shown is only one of the implementation methods of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims

1. A veterinary drug composition, characterized in that: The invention is prepared from the following medicines in the following weight proportions: 6-13 parts of penicillin, 0.5-1.4 parts of Lycium barometz leaf extract and 0.5-1.4 parts of fish extract.

2. A veterinary drug composition according to claim 1, characterized in that: The invention is prepared from the following drugs in the following weight proportions: 10 parts of penicillin, 1 part of Lycium barometz leaf extract and 1 part of fish extract.

3. A veterinary drug composition according to claim 1, characterized in that: The invention is prepared from the following drugs in the following weight proportions: 8 parts of penicillin, 0.8 parts of Lycium barometz leaf extract and 1.1 parts of fish extract.