Soothing composition for increasing sensitive reaction threshold value, soothing moisturizing gel and preparation method of soothing moisturizing gel

Abstract

The invention relates to the technical field of cosmetics, in particular to a soothing composition for increasing a sensitive reaction threshold value, soothing moisturizing gel and a preparation method of the soothing composition and the soothing moisturizing gel. The soothing composition capable of increasing the sensitive reaction threshold value is prepared from the following components in parts by weight: 0.01 to 0.2 part of allantoin, 0.1 to 5 parts of D-panthenol, 0.01 to 0.5 part of palmitoyl tripeptide-8 and 0.1 to 2 parts of chamomile extract. According to the invention, allantoin, D-panthenol, palmitoyl tripeptide-8 and chamomile extract are combined in a specific weight part range to obtain the soothing composition capable of effectively increasing a sensitive reaction threshold. The four components are mutually matched and synergistically play a role, so that the use of the active component palmitoyl tripeptide-8 is reduced, the cost input is effectively reduced, the skin inflammation reaction is jointly inhibited, the relieving and redness removing effects of the product are synergistically enhanced, and the sensitive reaction threshold value and the overall tolerance of the skin are effectively improved.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a soothing composition for increasing a sensitive reaction threshold, a soothing and moisturizing gel, and a preparation method thereof. Background Art

[0002] With fluctuating environmental conditions, seasonal changes, the potential for irritation from facial skincare products, and the overuse of cosmetics containing hormones, the problem of sensitive skin has become increasingly prominent and serious. Consequently, the cosmetics industry has focused on effective skin care, particularly for sensitive skin, a field of research that is attracting increasing attention. Skincare products specifically designed to treat sensitive skin have become a popular choice on the market.

[0003] Sensitive skin cells are easily damaged, leading to a weakened stratum corneum and consequently severe moisture loss, resulting in a significant drop in water content. This weakens the immune system, making sensitive skin susceptible to adverse reactions such as redness, fever, itching, and stinging when exposed to external stimuli (such as climate change, cosmetic ingredients, and UV rays). Therefore, the most important repair strategy for sensitive skin lies in increasing skin hydration, strengthening the skin's barrier function, and effectively alleviating the skin's stress response to external stimuli, thereby calming, soothing, and promoting skin repair.

[0004] While there are a variety of skincare products for sensitive skin on the market, most focus on moisturizing and soothing, with few addressing the potential to reduce adverse reactions by raising the skin's sensitivity threshold. This threshold is the minimum intensity of stimulation required for the skin to noticeably react to a stimulus. This threshold is influenced by a variety of factors, including the nature, frequency, and duration of the stimulus, as well as the skin's previous condition. If the stimulus is intense and frequent, the skin may become even more sensitive, lowering the sensitivity threshold.

[0005] Palmitoyl Tripeptide-8 is a new type of peptide that relieves neuroinflammation in sensitive skin. It is derived from neurotransmitters connected to lipids and has anti-inflammatory, anti-irritation and soothing effects. It can calm and soothe irritated skin caused by ultraviolet rays, immune response and mechanical stress, and help maintain and restore normal skin sensitivity threshold.

[0006] Due to the high price of Palmitoyl Tripeptide-8, the amount added to cosmetics is limited, and the soothing effect is limited. In order to achieve the desired soothing effect, it needs to be compounded with other ingredients with soothing effects. It is very necessary to develop a soothing composition with high cost-effectiveness, high safety and good efficacy. Summary of the Invention

[0007] The purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art and to provide a soothing composition for increasing the threshold of sensitive reactions, a soothing moisturizing gel and a preparation method thereof that are cost-effective, safe, effective and widely applicable.

[0008] To achieve the above objectives, the technical solutions adopted by the present invention include: In a first aspect, the present invention provides a soothing composition for increasing the threshold of a sensitive reaction, comprising the following components in parts by weight: 0.01-0.2 parts of allantoin, 0.1-5 parts of D-panthenol, 0.01-0.5 parts of palmitoyl tripeptide-8, and 0.1-2 parts of chamomile extract; The weight portion of the palmitoyl tripeptide-8 is more than 1% of the total weight portion of the three components of allantoin, D-panthenol and chamomile extract.

[0009] Allantoin acts directly on the keratin in the skin, promoting the hydration capacity of the stratum corneum, increasing the softness and elasticity of the skin, while reducing water loss in the skin, relieving discomfort such as dryness and tightness of the skin, and providing a soothing effect on the skin; it can also inhibit the activity of inflammatory cells, thereby inhibiting the release of inflammatory mediators and reducing inflammatory responses; at the same time, it can also bind to cell surface receptors, regulate the activity of immune cells, and reduce skin inflammation and allergic reactions caused by excessive immune responses; it can also stimulate the proliferation of epidermal cells and increase the permeability of blood vessels, which is beneficial to the absorption of nutrients and the excretion of waste, thereby supporting cell growth and repair; at the same time, allantoin can also promote the growth of granulation tissue to accelerate the wound healing process, which helps to repair and rebuild the skin barrier.

[0010] Panthenol, a derivative of vitamin B5, has a small molecular weight and can effectively penetrate into the stratum corneum of the skin and be quickly converted into vitamin B5, participating in the synthesis of cholesterol and fatty acids, enhancing the structure and function of the stratum corneum, thereby reducing water loss; it can also increase the fluidity of filaggrin, promote lipid fusion, further improve and enhance the barrier function of the skin; it can also upregulate the expression of heme oxygenase 1 (HO-1) to further enhance the skin's antioxidant capacity and protect the skin from damage by ultraviolet rays and environmental pollution.

[0011] Palmitoyl tripeptide-8 can inhibit the production or release of pro-inflammatory cytokines, effectively reducing or inhibiting the inflammatory response on inflamed skin; it can also enhance the integrity of the skin barrier, thereby reducing damage to the skin by external stimuli and further alleviating inflammatory symptoms; finally, palmitoyl tripeptide-8 can also promote the repair and regeneration of damaged skin cells, maintain and restore the skin's normal sensitivity threshold, make the skin's response to external stimuli more moderate, and maintain the skin's health. However, when the content of palmitoyl tripeptide-8 in the product is too low, the soothing effect is very poor, while too high a content leads to high product costs.

[0012] Chamomile extract is rich in flavonoids, which can inhibit the release and activity of inflammatory mediators, thereby reducing skin inflammation; it can also enhance the resistance of capillaries, inhibit capillary permeability, and thereby reduce microvascular rupture and exudation caused by skin inflammation, further reducing sensitive reactions; chamomile extract is also rich in antioxidants, which can eliminate free radicals and protect the skin from damage by the external environment; at the same time, it can also improve the metabolism and repair ability of skin cells, increase the skin's sensitive reaction threshold, and enhance the skin's tolerance and resistance.

[0013] The present invention combines allantoin, D-panthenol, palmitoyl tripeptide-8, and chamomile extract within a specific weight range to produce a soothing composition that effectively increases the sensitivity reaction threshold. In this composition, the four ingredients work together synergistically, reducing the use of the active ingredient palmitoyl tripeptide-8, effectively reducing costs. They also jointly inhibit skin inflammatory reactions, synergistically enhancing the product's soothing and redness-reducing effects, and effectively increasing the skin's sensitivity reaction threshold and overall tolerance.

[0014] Preferably, the soothing composition for increasing the threshold of sensitive reaction comprises the following components in parts by weight: 0.05-0.2 parts of allantoin, 0.5-2 parts of D-panthenol, 0.02-0.2 parts of palmitoyl tripeptide-8, and 0.5-2 parts of chamomile extract.

[0015] After extensive testing and exploration, the inventors discovered that when the weight percentages of the components in the soothing composition are within the preferred range described in the present invention, the soothing and moisturizing gel prepared from the composition has a better improvement rate in histamine stinging and histamine redness. Long-term use can effectively improve skin tolerance, that is, increase the skin's sensitive reaction threshold, and each component in the composition fully exerts its role, ultimately achieving better soothing, anti-inflammatory, and redness-reducing effects.

[0016] Preferably, the soothing composition for increasing the threshold of sensitive reaction comprises: 0.1 part of allantoin, 1 part of D-panthenol, 0.1 part of palmitoyl tripeptide-8, and 1 part of chamomile extract.

[0017] When the weight proportions of the components in the soothing composition are the most preferred values ​​described in the present invention, the soothing and moisturizing gel prepared by the composition has the best soothing effect and the highest cost-effectiveness.

[0018] In a second aspect, the present invention further provides a soothing and moisturizing gel comprising the soothing composition.

[0019] A soothing and moisturizing gel, comprising the following components: Phase A: 0.1%-1% acrylates / C10-30 alkyl acrylate crosspolymer, 0.15%-0.4% sodium acrylates copolymer, 0.05-0.2% lecithin, 0.5-5% glycerol polyether-26, 1-4% glycerol, 0.5-3% butylene glycol, and appropriate amount of deionized water; Phase B: 0.2%-0.4% parahydroxyacetophenone, 0.2%-0.4% hexylene glycol, 0.01%-0.8% arginine, 0.5%-8% of the above soothing composition.

[0020] In a third aspect, the present invention further provides a method for preparing the soothing and moisturizing gel as described above, which specifically comprises: S1: Mix and disperse phase A evenly, and heat to 75-85℃; S2: Cool down to 40-45℃, add phase B and mix well.

[0021] Compared with the prior art, the present invention has the following beneficial effects: The present invention combines allantoin, D-panthenol, palmitoyl tripeptide-8, and chamomile extract within a specific weight range to produce a soothing composition that effectively increases the sensitivity reaction threshold. The four ingredients work synergistically, reducing the use of the active ingredient palmitoyl tripeptide-8, effectively reducing costs. They also jointly inhibit skin inflammatory reactions, synergistically enhancing the product's soothing and redness-reducing effects, and effectively increasing the skin's sensitivity reaction threshold and overall tolerance. DETAILED DESCRIPTION

[0022] The present invention provides a soothing composition, a soothing moisturizing gel, and a preparation method thereof for increasing the threshold of a sensitive reaction. To clarify and clarify the objectives, technical solutions, and effects of the present invention, the present invention is described in further detail below. It should be understood that the specific embodiments described herein are merely illustrative of the present invention and are not intended to limit the present invention.

[0023] A soothing and moisturizing gel for increasing the threshold of sensitive reactions is composed of the following components, calculated by weight percentage. The specific contents of Examples 1-5 and the control group are shown in Table 1 below:

[0024] A soothing moisturizing gel for increasing the threshold of sensitive reactions is composed of the following components, calculated by weight percentage. The specific contents of Comparative Examples 1-8 are shown in Table 2 below:

[0025] The preparation method of the soothing and moisturizing gel described in the embodiments and comparative examples of the present invention comprises the following steps: S1: Mix and disperse phase A evenly, and heat to 75-85℃; S2: Cool down to 40-45℃, add phase B and mix well.

[0026] Performance test: The soothing and moisturizing gels prepared in Examples 1-5 and Comparative Examples 1-8 were subjected to the following performance tests:

[0027] 1. Irritation test: According to SN / T 2329-2009 Chicken Embryo Chorioallantoic Test for Eye Irritation / Corrosion of Cosmetics, irritation tests were conducted on the samples of Examples 1-5 and Comparative Examples 1-8. The test data are recorded in Table 4. The test and evaluation criteria are shown in Table 3:

[0028] Table 4: Irritation test results:

[0029] Conclusion: As can be seen from Table 4, all 13 samples showed no or mild irritation, indicating that the soothing and moisturizing gels provided by the present invention are safe and non-irritating.

[0030] 2. Soothing effect test: In order to verify that the present invention has the ability to soothe and enhance the sensitivity reaction threshold, the soothing and moisturizing gels of Examples 1-5, the control group, and comparative examples 1-8 were subjected to a histamine stimulation test.

[0031] Test subjects: People with histamine-positive sensitive skin, no serious systemic diseases, no immune deficiency or autoimmune diseases, and no previous skin treatment, beauty treatment, or other behaviors that may affect the results.

[0032] Number of testers: 10 people / group, 14 groups in total.

[0033] Test method:

[0034] (1) No cosmetics or medicines should be used on the test area on the test day. The test subject should wash the skin with clean water and then dry the skin surface with dry tissue paper. The test subject should sit quietly for 30 minutes in a constant temperature and humidity environment. During this period, he should not drink water or eat any food and should remain relaxed. A 2cm*2cm test area should be divided on the inner side of the subject's arms.

[0035] (2) Use a pipette to take 0.02 ml of 1% histamine aqueous solution and apply it to the test area. After five minutes, when redness, swelling and itching reactions appear on the skin, take 0.02 g of the test sample and the control group sample and apply them evenly to the test area. Ask the subjects about their subjective symptoms (itching and redness and swelling reduction effect) at 0 min, 15 min and 30 min respectively, record the redness and itching of the arm at each time point, and score and record. For the sensitive reaction threshold test, after the tester has used the sample in the above test area for 1 week, the above histamine test is performed again in the test area. Ask the subjects about their subjective symptoms (itching and redness and swelling reduction effect) at 0 min, 15 min and 30 min respectively, record the redness and itching of the arm at each time point, and score and record.

[0036] Histamine sting improvement rate (%) = (stinging pain score at 0 minutes after histamine application - stinging pain score at n minutes after histamine application) × 100% / stinging pain score at 0 minutes after histamine application;

[0037] Histamine redness improvement rate (%) = (redness score at 0 minutes after histamine application - redness score n minutes after histamine application) × 100% / redness score at 0 minutes after histamine application;

[0038] Itch / pain scoring criteria: 5 points: obvious severe itching / pain, can't help scratching / unbearable; 4 points: obvious itching / pain, occasional urge to scratch / tolerable; 3 points: mild itching / pain, no treatment is required; 2 points: vague itching / pain, unable to be accurately described; 1 point: No itching or pain.

[0039] Redness rating scale: 5 points: obvious and severe redness; 4 points: obvious redness; 3 points: moderate redness; 2 points: very slight redness; Score 1: No redness, same skin color as untreated area.

[0040] Table 5: Histamine test data of Examples, Control Group and Comparative Examples

[0041] Conclusion: As shown in Table 5, when the weight parts of the components in the soothing composition are within the preferred range of the present invention, the gels prepared in Examples 1-5 have good histamine stinging improvement rate and histamine redness improvement rate, and long-term use can effectively improve skin tolerance, that is, increase the skin's sensitive reaction threshold, and each component in the composition fully exerts its role, ultimately achieving better soothing, anti-inflammatory and redness-reducing effects; when the weight parts of the components in the compositions of Examples 1 and 3 are within the more preferred range of the present invention, the soothing, anti-inflammatory and redness-reducing effects of the prepared gels are further improved; and by comparing Example 2 and Example 3, it can be seen that the palmitoyl tripeptide- The addition amount of 8 is twice that of Example 2, that is, the raw material cost of Example 3 is nearly twice that of Example 2, but the soothing effect is not significantly improved compared with Example 2. Example 5, like Example 2, fails to achieve the better soothing effect corresponding to Example 2 in terms of raw material cost. Therefore, from the comprehensive evaluation of cost performance and soothing effect, the weight parts of the components of the composition in Example 2 are the most preferred values ​​of the present invention, indicating that when palmitoyl tripeptide-8 and allantoin, D-panthenol and chamomile extract in the composition are used in combination within a specific dosage range, they interact with each other and exert a synergistic effect, thereby maximizing the soothing effect of the product.

[0042] In addition, by comparing Comparative Examples 1-4 and Comparative Examples 6-7 with Example 2, it can be seen that when Comparative Example 1 lacks palmitoyl tripeptide-8, allantoin, and chamomile extract, and Comparative Examples 2-4 lack any two of the above three components, and Comparative Examples 6-7 lack palmitoyl tripeptide-8 and chamomile extract respectively, the histamine stinging improvement rate and the histamine redness improvement rate of the final gel are significantly lower than those in Example 2, that is, the soothing effect is significantly worse. The above conclusions fully illustrate that the four components of palmitoyl tripeptide-8, allantoin, D-panthenol and chamomile extract in the composition of the present invention cooperate with each other and interact with each other to synergistically enhance the soothing effect of the composition, and none of the four components can be missing; in addition, when the amount of palmitoyl tripeptide-8 added in Comparative Example 8 is less than 1% compared to the total amount of allantoin, chamomile extract and D-panthenol added, The histamine stinging improvement rate and histamine redness improvement rate of the prepared gel also decreased significantly, indicating that palmitoyl tripeptide-8, as one of the key components of the composition, will have an important impact on improving the sensitive reaction threshold and soothing effect of the sample. When the content of palmitoyl tripeptide-8 in the composition is too low, a good soothing effect and improved skin tolerance are basically not achieved; at the same time, the amount of palmitoyl tripeptide-8 in Comparative Example 5 exceeds the specified range of the present invention, while the amounts of the other components are the same as in Example 3. The histamine stinging improvement rate and histamine redness improvement rate of the prepared gel are basically the same as those in Example 3, and the cost-effectiveness is significantly reduced. This shows that when the amount of each component in the composition is within the specified range of the present invention, the synergistic effect can be better exerted to significantly improve the soothing effect of the product and increase the sensitive reaction threshold of the skin, while effectively reducing the cost investment.

[0043] In summary, the present invention provides a soothing composition for improving the threshold value of sensitive reactions with high cost-effectiveness, high safety, good efficacy and wide applicability. By combining allantoin, D-panthenol, palmitoyl tripeptide-8 and chamomile extract within a specific weight range, a soothing composition that can effectively improve the threshold value of sensitive reactions is obtained. The four ingredients cooperate with each other and work synergistically, reducing the use of the active ingredient palmitoyl tripeptide-8, effectively reducing cost investment, and jointly inhibiting skin inflammatory reactions, synergistically enhancing the soothing and redness-reducing effect of the product, and effectively improving the skin's sensitive reaction threshold and overall tolerance.

[0044] Throughout this specification, references to terms such as "one embodiment," "example," or "specific example" indicate that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of these terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0045] The preferred embodiments of the present invention disclosed above are intended only to help illustrate the present invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the present invention to the specific embodiments described. Obviously, many modifications and variations are possible based on the content of this specification. These embodiments are selected and described in detail in this specification to better explain the principles and practical applications of the present invention, thereby enabling those skilled in the art to better understand and utilize the present invention. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. The present invention provides a soothing composition for increasing the threshold of sensitive reactions, characterized in that: The invention comprises the following components in parts by weight: 0.01-0.2 parts of allantoin, 0.1-5 parts of D-panthenol, 0.01-0.5 parts of palmitoyl tripeptide-8 and 0.1-2 parts of chamomile extract; the weight of the palmitoyl tripeptide-8 is more than 1% of the total weight of the three components of allantoin, D-panthenol and chamomile extract.

2. A soothing composition for increasing the threshold of sensitive reactions according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 0.05-0.2 parts of allantoin, 0.5-2 parts of D-panthenol, 0.02-0.2 parts of palmitoyl tripeptide-8 and 0.5-2 parts of chamomile extract.

3. A soothing composition for increasing the threshold of sensitive reaction according to claim 2, characterized in that: The invention comprises the following components in parts by weight: 0.1 part of allantoin, 1 part of D-panthenol, 0.1 part of palmitoyl tripeptide-8 and 1 part of chamomile extract.

4. A soothing and moisturizing gel, characterized in that: A soothing composition for increasing the threshold of sensitive reactions comprising any one of claims 1 to 3.

5. A soothing and moisturizing gel according to claim 4, characterized in that: The soothing and moisturizing gel includes the following components: Phase A: 0.1%-1% acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, 0.15%-0.4% acrylic acid (ester) copolymer sodium, 0.05-0.2% lecithin, 0.5-5% glyceryl polyether-26, 1-4% glycerol, 0.5-3% butylene glycol, appropriate amount of deionized water; Phase B: 0.2%-0.4% p-hydroxyacetophenone, 0.2%-0.4% hexylene glycol, 0.01%-0.8% arginine, 0.5%-8% of the above soothing composition.

6. A method for preparing a soothing and moisturizing gel according to claim 5, characterized in that: The following steps are involved: S1: Mix and disperse phase A evenly, and heat to 75-85℃; S2: Cool down to 40-45℃, add phase B, mix and disperse evenly.

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