High-safety supercritical extraction equipment for pharmacy

Abstract

The invention relates to pharmaceutical high-safety supercritical extraction equipment which comprises an extraction tank body, an auxiliary shell, a filter screen cover, a partition plate, a drainage cylinder, a drainage opening, a spiral wheel, a tank cover, a tank body rod and a tank inner cork.The auxiliary shell is additionally arranged on the extraction tank body, and an extraction medium is driven by the spiral wheel to circularly flow between the extraction tank body and the auxiliary shell; according to the technical scheme, flowing extraction media are filtered through the filter screen cover, extraction materials are prevented from entering the auxiliary shell, the extraction media are mixed with the extraction materials through flowing scouring of the extraction media, the mixing effect of the extraction media and the extraction materials is effectively improved, and in the technical scheme, the mixing mode of the extraction media and the extraction materials is simpler; according to the technical scheme, the mixing structure is located in the auxiliary shell and does not occupy the central area of the extraction tank body, and the internal extraction materials are rapidly taken out by pulling out the inner plug of the tank, so that the replacement efficiency of the extraction materials is effectively improved.

Description

Technical Field

[0001] The invention relates to a supercritical extraction device, in particular to a high-safety supercritical extraction device for pharmaceutical use applied in the technical field of supercritical extraction. Background Art

[0002] Supercritical extraction is a technology that uses supercritical fluid as an extraction medium to separate different components in a mixture. Supercritical fluid refers to a fluid state that is above its critical temperature and critical pressure. In this state, the fluid has unique solubility and diffusion properties, making it an effective medium in the extraction process. In order to fully mix the extraction medium with the extraction material, the extraction tank will have a stirring structure, but the active stirring structure will affect the difficulty of sealing the extraction tank and affect the safety performance of the extraction equipment.

[0003] The specification of Chinese invention patent CN201921156181.1 discloses "A liquid fractionation kettle for supercritical extraction", which drives the stirring shaft to rotate by non-contact electromagnetic stirring. In the overall equipment, only the two large positions between the kettle cover and the kettle body unit and between the stirring shaft sleeve and the kettle cover need to fully ensure the sealing, so as to avoid the conventional stirring method resulting in poor sealing and safety risks.

[0004] When extracting certain solid materials that are not suitable for pulverization pretreatment, it is necessary to keep the fiber structure of natural products unchanged. The extraction equipment needs to be opened for feeding and discharging. The extraction materials are loaded at one time and the supercritical fluid is continuously introduced. The materials in the extraction tank need to be replaced frequently manually. However, the traditional stirring shaft structure and the magnetic stirring shaft structure in the above patent are both located in the center of the extraction tank, resulting in a relatively complex replacement environment for the extraction materials. The entry and exit of the extraction materials are blocked by the mixing structure, which affects the replacement efficiency of the extraction materials. Summary of the invention

[0005] In view of the above-mentioned prior art, the technical problem to be solved by the present invention is that the traditional stirring shaft structure and the magnetic stirring shaft structure in the above-mentioned patent are both located in the center of the extraction tank, which makes the replacement environment of the extraction material relatively complex and affects the replacement efficiency of the extraction material.

[0006] In order to solve the above problems, the present invention provides a high-safety supercritical extraction device for pharmaceutical use, comprising an extraction tank body, the top of the extraction tank body is fixedly connected to an auxiliary shell, and a filter cover is fixedly connected between the extraction tank body and the auxiliary shell, the top and bottom of the auxiliary shell are respectively fixedly connected to an output pipe and an input pipe, and a partition plate is fixedly connected to the middle of the auxiliary shell, a drainage cylinder is fixedly connected between the partition plate and the input pipe, the lower opening of the drainage cylinder faces the filter cover, and a drainage port is opened between the drainage cylinder and the top of the partition plate, the interior of the drainage cylinder is rotatably connected to a spiral wheel, the outside of the auxiliary shell is fixedly connected to a driving motor, the output end of the driving motor and the tail of the spiral wheel are fixedly connected to magnetic suction wheels, and the two magnetic suction wheels are arranged to attract each other magnetically;

[0007] A tank cover is clamped inside the tank mouth of the extraction tank body, the inner end of the tank cover is fixedly connected to the tank body rod, the bottom end of the tank body rod is fixedly connected to the tank plug, the tank plug corresponds to the tank bottom of the extraction tank body, and the top of the tank plug is arranged in an inclined surface, and the inclined surface of the tank plug corresponds to the outlet of the drainage tube.

[0008] In the above-mentioned high-safety supercritical extraction equipment for pharmaceutical use, an auxiliary shell is added to the extraction tank body, and the extraction medium is driven by a spiral wheel to circulate between the extraction tank body and the auxiliary shell, so as to achieve mixing of the extraction medium and the extraction material. Compared with the traditional stirring and mixing structure, it is convenient for the sealing assembly of the extraction tank body, and effectively avoids the safety hazards caused by the poor sealing effect of the extraction tank body.

[0009] As a further improvement of the present application, the tank rod is close to the inner wall of the extraction tank, and the outer part of the tank rod is rotatably connected to a disturbance wheel, which is spherical in shape. The flowing extraction medium pushes the disturbance wheel, thereby utilizing the rotation of the disturbance wheel to further improve the mixing effect of the extraction medium and the extraction material.

[0010] As a further improvement of the present application, a plug door plate is fixedly connected between the disturbance wheel and the top of the inclined surface of the plug in the tank. The plug door plate and the partition plate correspond to the same plane. The plug door plate is used to extend the partition plate to separate the interior of the extraction tank body, thereby effectively preventing the extraction medium just discharged from the auxiliary shell from quickly returning to the auxiliary shell, thereby effectively increasing the contact time between the extraction medium and the extraction material.

[0011] As a further improvement of the present application, a focusing window is provided at the bottom of the gate plate, and the focusing window corresponds to the bottom of the disturbance wheel. The extraction medium flows through the focusing window in a concentrated manner, thereby achieving concentrated impact of the extraction medium on the disturbance wheel, thereby effectively improving the rotation effect of the disturbance wheel.

[0012] As another improvement of the present application, a storage groove is provided at the top of the plug door plate, and a sealing tape is placed inside the storage groove. The sealing tape is in close contact with the bottom end of the partition plate, and a sealing rubber pad is fixedly connected to the top contact surface of the sealing tape. The sealing tape is used in combination with the sealing rubber pad to effectively improve the contact effect with the partition plate, thereby effectively improving the effect of blocking the extraction medium.

[0013] As another improved supplement of the present application, the interior of the sealing belt is hollow and filled with inert gas, so that the sealing belt rises due to buoyancy and sinks back into the storage tank after the extraction medium is emptied.

[0014] As another improvement supplement of the present application, both ends of the upper opening of the storage tank are fixedly connected with an extended scraper frame, and the extended scraper frame corresponds to the lower surface of the filter cover. The extended scraper frame is used to clean the lower surface of the filter cover and prevent the extracted material from falling into the storage tank after cleaning.

[0015] As another improved supplement of the present application, a scraping brush is fixedly connected to the contact end of the extended scraper frame and the filter cover. The scraping brush is made of wear-resistant rubber material. The scraping brush is used to effectively improve the cleaning effect of the extended scraper frame on the lower surface of the filter cover.

[0016] As another improvement of the present application, a blocking sack is fixedly connected to the bottom end of the slope of the tank plug, and the blocking sack is arranged in an arc shape corresponding to the filter cover. The blocking sack is utilized to block the extraction material, thereby effectively improving the collection of the extraction material on the slope of the tank plug, and at the same time effectively preventing the extraction material from contacting the lower surface of the filter cover again when the tank plug is taken out.

[0017] To summarize, the present invention adds an auxiliary shell to the extraction tank body, and uses a partition plate to divide the internal space of the auxiliary shell into two areas, corresponding to the outflow area and the reflux area of ​​the extraction medium. Subsequently, the extraction medium is driven by a spiral wheel to circulate between the extraction tank body and the auxiliary shell, and the flowing extraction medium is filtered by a filter cover to prevent the extraction material from entering the auxiliary shell. The flow of the extraction medium is flushed to achieve mixing with the extraction material, thereby effectively improving the mixing effect of the extraction medium and the extraction material. Compared with the traditional stirring and mixing structure, the mixing structure of the extraction medium and the extraction material in the technical solution is located in the auxiliary shell and does not occupy the central area of ​​the extraction tank body, thereby providing a smooth material inlet and outlet environment for the extraction tank body, and the internal extraction material is quickly taken out by pulling out the plug in the tank, thereby effectively improving the replacement efficiency of the extraction material. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a three-dimensional structural diagram of the first embodiment of the present application;

[0019] Figure 2This is a three-dimensional structural diagram of the extraction tank and the auxiliary shell in the first embodiment of the present application;

[0020] Figure 3 This is a demonstration diagram of the circulation flow of the extraction medium in the first embodiment of the present application;

[0021] Figure 4 This is a sectional three-dimensional structural diagram of a partition plate in the first embodiment of the present application;

[0022] Figure 5 This is a three-dimensional structural diagram of the spiral wheel and the driving motor in the first embodiment of the present application;

[0023] Figure 6 This is a three-dimensional structural diagram of a tank cover and a tank plug according to a first embodiment of the present application;

[0024] Figure 7 This is a three-dimensional structural diagram of a tank plug according to a second embodiment of the present application;

[0025] Figure 8 This is a three-dimensional structural diagram of a plug door plate according to a second embodiment of the present application;

[0026] Fig. 9 This is a cross-sectional view of the storage groove according to the second embodiment of the present application.

[0027] Description of the numbers in the figure:

[0028] 1. Extraction tank body; 101. Auxiliary shell; 102. Filter cover; 103. Output pipe; 104. Input pipe; 105. Partition plate; 106. Drainage tube; 107. Drainage port; 108. Spiral wheel; 109. Driving motor; 110. Magnetic wheel; 2. Tank cover; 201. Tank rod; 202. Tank plug; 203. Disturbance wheel; 204. Plug door plate; 205. Centralizing window; 3. Storage slot; 301. Sealing tape; 302. Sealing rubber pad; 303. Outward scraper; 304. Scraping brush; 305. Blocking bag plate. DETAILED DESCRIPTION

[0029] Two implementation modes of the present application are described in detail below with reference to the accompanying drawings.

[0030] The first implementation method:

[0031] Figures 1 to 5It is shown that a high-safety supercritical extraction equipment for pharmaceutical use comprises an extraction tank body 1, the top of the extraction tank body 1 is fixedly connected with an auxiliary shell 101, and a filter cover 102 is fixedly connected between the extraction tank body 1 and the auxiliary shell 101, the top and bottom of the auxiliary shell 101 are respectively fixedly connected with an output pipe 103 and an input pipe 104, and a partition plate 105 is fixedly connected to the middle of the auxiliary shell 101, a drainage cylinder 106 is fixedly connected between the partition plate 105 and the input pipe 104, the lower opening of the drainage cylinder 106 faces the filter cover 102, and a drainage port 107 is opened between the drainage cylinder 106 and the top of the partition plate 105, the drainage cylinder 106 is rotatably connected with a spiral wheel 108 inside, and a driving motor 109 is fixedly connected to the outside of the auxiliary shell 101, and a magnetic attraction wheel 110 is fixedly connected to the output end of the driving motor 109 and the tail of the spiral wheel 108, and the two magnetic attraction wheels 110 are arranged to attract each other by magnetic force;

[0032] When supercritical extraction of medicinal materials is performed, the auxiliary housing 101 is divided into two areas according to the partition plate 105, corresponding to the outflow area and the reflux area of ​​the extraction medium. The input pipe 104 feeds the extraction medium into the outflow area, and the output pipe 103 discharges the extraction medium from the reflux area. When the extraction medium stops inputting and outputting, the non-contact transmission connection between the driving motor 109 and the spiral wheel 108 is realized through the magnetic attraction of the two magnetic wheels 110. The spiral wheel 108 drives the extraction medium in the drainage tube 106 to fill the bottom of the extraction tank body 1, so that the extraction medium flows along the inclined surface of the plug 202 in the tank. , and then rises along the extraction tank body 1 and mixes with the extraction material in the extraction tank body 1. Finally, the extraction material passes through the filter screen cover 102 again and enters the reflux area. The extraction material in the reflux area enters the drainage tube 106 again through the drainage port 107, so that the extraction medium circulates between the extraction tank body 1 and the auxiliary shell 101, prolongs the mixing time of the extraction material and the extraction medium, and effectively improves the mixing effect of the extraction medium and the extraction material, thereby effectively improving the extraction quality. At the same time, a relatively open and unobstructed environment is maintained in the extraction tank body 1, which is convenient for the replacement operation of the extraction material in the extraction tank body 1.

[0033] Figure 1 and Figure 3 As shown, a tank cover 2 is clamped inside the tank mouth of the extraction tank body 1, a tank body rod 201 is fixedly connected to the inner end of the tank cover 2, and a tank plug 202 is fixedly connected to the bottom end of the tank body rod 201, and the tank plug 202 corresponds to the tank bottom of the extraction tank body 1, and the top of the tank plug 202 is arranged in an inclined surface, and the inclined surface of the tank plug 202 corresponds to the outlet of the drainage tube 106;

[0034] Before the extraction work is carried out, the drug extraction material is inserted into the extraction tank body 1 together with the tank plug 202, ensuring that the tank plug 202 is at the bottom of the extraction tank body 1 and the extraction material is at the top of the tank plug 202. When replacing the extraction material in the extraction tank body 1, the tank cover 2 is removed, and the tank plug 202 is pulled outward through the tank cover 2. The tank plug 202 is used to push the extraction material in the extraction tank body 1, so that the tank plug 202 brings the extraction material out of the extraction tank body 1, effectively improving the replacement efficiency of the extraction material.

[0035] Figures 3 to 6 As shown, the tank rod 201 is close to the inner wall of the extraction tank body 1, and the outer part of the tank rod 201 is rotatably connected with a disturbance wheel 203, which is spherical. The flowing extraction medium pushes the disturbance wheel 203, so that the rotation of the disturbance wheel 203 further improves the mixing effect of the extraction medium and the extraction material. A plug door plate 204 is fixedly connected between the disturbance wheel 203 and the top of the inclined surface of the plug 202 in the tank. The plug door plate 204 corresponds to the same plane as the partition plate 105, and the plug door plate 204 is used to extend the partition plate 105. The partition 105 separates the inside of the extraction tank 1, effectively preventing the extraction medium just discharged from the auxiliary shell 101 from returning to the auxiliary shell 101 quickly, thereby effectively increasing the contact time between the extraction medium and the extraction material. A concentration window 205 is provided at the bottom of the plug gate plate 204, and the concentration window 205 corresponds to the bottom of the disturbance wheel 203. The extraction medium flows through the concentration window 205 in a concentrated manner, thereby realizing the extraction medium concentrated impact on the disturbance wheel 203, thereby effectively improving the rotation effect of the disturbance wheel 203.

[0036] By combining the gate plate 204 with the partition plate 105, the blocking effect of the partition plate 105 on the extraction medium is extended to the inside of the partition plate 105, thereby effectively increasing the contact time between the extraction medium and the extraction material. The extraction medium blocked by the gate plate 204 descends and finally passes through the concentration window 205 at the bottom of the gate plate 204, so that the flowing extraction medium can more concentratedly push the disturbance wheel 203 to rotate, and the rotation of the disturbance wheel 203 is used to provide a mixing effect of the extraction medium and the extraction material. The gate plate 204 extends the partition plate 105 to separate the inside of the extraction tank body 1, effectively preventing the extraction medium just discharged from the auxiliary shell 101 from quickly returning to the auxiliary shell 101, thereby effectively improving the circulation flow effect of the extraction medium, and by opening the concentration window 205 at the bottom of the gate plate 204, the extraction medium is concentrated, thereby effectively improving the impact effect of the extraction medium on the disturbance wheel 203, thereby effectively improving the rotation effect of the disturbance wheel 203.

[0037] The second implementation method:

[0038] Compared with the first embodiment, this embodiment mainly adds a sealing belt 301. The specific newly added structure is as follows, and the remaining structures are consistent with the first embodiment.

[0039] Figures 7 and 8 As shown, a receiving groove 3 is provided at the top of the plug door plate 204, and a sealing tape 301 is placed inside the receiving groove 3. The sealing tape 301 is in close contact with the bottom end of the partition plate 105, and a sealing rubber pad 302 is fixedly connected to the top contact surface of the sealing tape 301. The sealing tape 301 cooperates with the sealing rubber pad 302 to effectively improve the contact effect with the partition plate 105, thereby effectively improving the effect of blocking the extraction medium. The interior of the sealing tape 301 is hollow, and the interior of the sealing tape 301 is filled with inert gas, so that the sealing tape 301 rises due to buoyancy, and after the extraction medium is emptied, the sealing tape 301 sinks back into the receiving groove 3;

[0040] After the extraction tank body 1 is filled with the extraction medium, the sealing tape 301 in the storage tank 3 rises due to its own buoyancy, and cooperates with the sealing rubber pad 302 to effectively improve the contact effect with the partition plate 105, thereby effectively improving the blocking and sealing effect of the top of the plug plate 204 on the extraction medium, and effectively improving the drainage capacity of the extraction medium. The hollow sealing tape 301 effectively improves its own buoyancy, and even if the filled inert gas leaks, it can effectively avoid contamination of the extraction material.

[0041] Figures 7 to 9 As shown, both ends of the upper opening of the storage tank 3 are fixedly connected with an extended scraper 303, and the extended scraper 303 corresponds to the lower surface of the filter cover 102. The extended scraper 303 is used to clean the lower surface of the filter cover 102 and prevent the extracted materials from falling into the storage tank 3. The contact end of the extended scraper 303 and the filter cover 102 is fixedly connected with a scraping brush 304, and the scraping brush 304 is made of wear-resistant rubber material. 4. Effectively improve the cleaning effect of the extended scraper 303 on the lower surface of the filter cover 102. The bottom end of the inclined surface of the tank plug 202 is fixedly connected with a blocking plate 305. The blocking plate 305 is arranged in an arc shape corresponding to the filter cover 102. The blocking plate 305 is used to block the extraction material, effectively improve the collection of the extraction material on the inclined surface of the tank plug 202, and effectively prevent the extraction material from contacting the lower surface of the filter cover 102 again when the tank plug 202 is taken out;

[0042] When replacing the extraction material in the extraction tank body 1, the extraction medium in the extraction tank body 1 is first emptied to restore the internal pressure of the extraction tank body 1 to normal pressure, and then the tank cover 2 is opened and the tank plug 202 is pulled out. During the process of pulling out the tank plug 202, the lower surface of the filter cover 102 is cleaned by using the extended scraper 303 on the plug door plate 204. The extended scraper 303 is in a state of extending outward from the storage tank 3, which effectively prevents the extraction material from entering the storage tank 3, and the sealing belt 301 no longer rises due to buoyancy. The sealing tape 301 sinks into the storage groove 3, thereby effectively separating the plug door plate 204 from the partition plate 105 and the filter cover 102, thereby effectively avoiding friction between the sealing tape 301 and the filter cover 102, so as to increase the service life of the sealing tape 301 and facilitate the movement of the plug door plate 204. Finally, the extracted material is supported by the inclined surface of the tank plug 202 and taken out of the tank plug 202, and the blocking plate 305 prevents the extracted material from contacting the filter cover 102 again along the inclined surface of the tank plug 202, thereby effectively improving the extraction effect of the extracted material.

[0043] In view of current practical needs, the above-mentioned implementation mode adopted in this application is not limited to the scope of protection. Various changes made within the knowledge scope of technical personnel in this field without departing from the concept of this application still fall within the scope of protection of the present invention.

Claims

1. A highly safe supercritical extraction equipment for pharmaceutical use, characterized in that: The invention comprises an extraction tank body (1), wherein the top of the extraction tank body (1) is fixedly connected to an auxiliary shell (101), and a filter cover (102) is fixedly connected between the extraction tank body (1) and the auxiliary shell (101), the top and bottom of the auxiliary shell (101) are respectively fixedly connected to an output pipe (103) and an input pipe (104), and a partition plate (105) is fixedly connected to the middle of the auxiliary shell (101), and a drainage tube (106) is fixedly connected between the partition plate (105) and the input pipe (104), The lower opening of the drainage tube (106) faces the filter cover (102), and a drainage port (107) is provided between the drainage tube (106) and the top of the partition plate (105). The interior of the drainage tube (106) is rotatably connected to a spiral wheel (108), and the exterior of the auxiliary housing (101) is fixedly connected to a driving motor (109). The output end of the driving motor (109) and the tail of the spiral wheel (108) are both fixedly connected to a magnetic attraction wheel (110), and the two magnetic attraction wheels (110) are arranged to attract each other by magnetic force; A tank cover (2) is clamped inside the tank mouth of the extraction tank body (1); the inner end of the tank cover (2) is fixedly connected to a tank body rod (201); the bottom end of the tank body rod (201) is fixedly connected to a tank plug (202); the tank plug (202) corresponds to the tank bottom of the extraction tank body (1), and the top of the tank plug (202) is arranged in an inclined surface; the inclined surface of the tank plug (202) corresponds to the outlet of the drainage tube (106).

2. A highly safe supercritical extraction device for pharmaceutical use according to claim 1, characterized in that: The tank body rod (201) is close to the inner wall of the extraction tank body (1), and the outside of the tank body rod (201) is rotatably connected to a disturbance wheel (203), and the disturbance wheel (203) is spherically arranged.

3. A highly safe supercritical extraction device for pharmaceutical use according to claim 2, characterized in that: A plug door plate (204) is fixedly connected between the disturbance wheel (203) and the top of the inclined surface of the plug (202) in the tank, and the plug door plate (204) corresponds to the partition plate (105) in the same plane.

4. A highly safe supercritical extraction device for pharmaceutical use according to claim 3, characterized in that: A centralizing window (205) is provided at the bottom of the gate plate (204), and the centralizing window (205) corresponds to the bottom of the disturbance wheel (203).

5. A highly safe supercritical extraction equipment for pharmaceutical use according to claim 1, characterized in that: The top end of the plug door plate (204) is provided with a receiving groove (3), a sealing belt (301) is placed inside the receiving groove (3), the sealing belt (301) is in close contact with the bottom end of the partition plate (105), and a sealing rubber pad (302) is fixedly connected to the top contact surface of the sealing belt (301).

6. A highly safe supercritical extraction device for pharmaceutical use according to claim 5, characterized in that: The interior of the sealing belt (301) is hollow and is filled with inert gas.

7. A highly safe supercritical extraction device for pharmaceutical use according to claim 5, characterized in that: Both ends of the upper opening of the storage groove (3) are fixedly connected with an outwardly extending scraper frame (303), and the outwardly extending scraper frame (303) corresponds to the lower surface of the filter screen cover (102).

8. A highly safe supercritical extraction device for pharmaceutical use according to claim 7, characterized in that: A scraping brush (304) is fixedly connected to the contact end of the extended scraper frame (303) and the filter screen cover (102), and the scraping brush (304) is made of a wear-resistant rubber material.

9. A highly safe supercritical extraction device for pharmaceutical use according to claim 1, characterized in that: The bottom end of the inclined surface of the tank plug (202) is fixedly connected with a blocking plate (305), and the blocking plate (305) is arranged in an arc shape corresponding to the filter cover (102).

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