A preparation device and method for cefditoren pivoxil mother core

Abstract

The invention is applicable to the technical field of cefditoren pivoxil mother core preparation, and provides a preparation device and a preparation method of cefditoren pivoxil mother core, comprising a base, a support rod is fixedly connected to the top of the base, a mixing barrel is arranged on the top of the base, a top cover extending to the outside of the adjusting tank is slidably connected to the inside of the adjusting tank, a power mixing component is arranged on the top cover, a flushing component is arranged on the top of the top cover, the power mixing component comprises a rotating main shaft, and the surface of the rotating main shaft is rotatably connected to the inside of the top cover. The invention provides a preparation device and a preparation method of cefditoren pivoxil mother core, wherein a pressing plate is driven to move up and down by a hydraulic press, and the pressing plate can extrude the material inside the mixing barrel during the rotation process, and the material can be continuously filtered and extruded through the filter holes during the extrusion process, and the material dispersed in the stock solution is effectively and evenly mixed, so that the material can be mixed more smoothly.

Description

Technical Field

[0001] The invention relates to the technical field of cefditoren pivoxil mother core preparation, and more specifically, to a device and method for preparing cefditoren pivoxil mother core. Background Art

[0002] Cefditoren pivoxil core is an important pharmaceutical intermediate, mainly used for the synthesis of cefditoren pivoxil, which has good antibacterial effects on a variety of bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, Proteus, etc.

[0003] In the preparation process of cefditoren mother core, when removing the 2-position protection, it is divided into chemical method and enzymatic method. The chemical method uses highly corrosive and environmentally unfriendly materials such as phosphorus pentachloride and pyridine, which cause great corrosion to the equipment, while the enzymatic method has mild reaction conditions and high efficiency, which meets the environmental protection requirements of modern pharmaceuticals. Among them, stirring plays a vital role in the enzymatic hydrolysis process of the preparation of cefditoren pivoxil mother core, which helps to mix the enzyme and the substrate.

[0004] In the prior art, most of the equipment used for processing cefditoren pivoxil core has a simple structure, and the stirring work of the processed raw materials is mostly carried out by a stirring rod. However, this stirring method cannot filter or extrude the materials, making it difficult for the solid enzyme dispersed in the stock solution to be effectively and evenly mixed, which easily leads to the problem of uneven mixing of the enzyme and the substrate. Summary of the invention

[0005] In view of the shortcomings of the prior art, the object of the present invention is to provide a device and a method for preparing a cefditoren pivoxil mother core.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] A preparation device for a cefditoren pivoxil mother core comprises a base, a support rod is fixedly connected to the top of the base, a mixing barrel is arranged on the top of the base, an adjusting groove is provided on the side of the support rod close to the mixing barrel, a top cover extending to the outside of the adjusting groove is slidably connected inside the adjusting groove, a power mixing component is arranged on the top cover, and a flushing component is arranged on the top of the top cover;

[0008] The power mixing assembly includes a rotating main shaft, the surface of the rotating main shaft is rotatably connected to the inside of the top cover, the outer surface of the rotating main shaft is fixedly connected to a driven gear, the top of the top cover is fixedly connected to a second motor, the output end of the second motor is fixedly connected to a driving gear, the surface of the driving gear is meshed with the surface of the driven gear, the bottom end of the rotating main shaft is fixedly connected to a support plate, the bottom of the support plate is fixedly connected to a hydraulic press, the output end of the hydraulic press is fixedly connected to a pressure plate, and the inside of the pressure plate is provided with a filter hole extending to the outside of the pressure plate.

[0009] The present invention is further configured as follows: a power disturbance mixing assembly is provided at the bottom of the support plate, the power disturbance mixing assembly includes a positioning shaft, the top end of the positioning shaft is fixedly connected to the bottom of the support plate, a rotating ring is rotatably connected inside the pressure plate, the rotating ring is movably sleeved on the positioning shaft, a power groove is provided inside the pressure plate, the rotating ring is provided inside the power groove, the outer surface of the rotating ring is provided with teeth, the inner surface of the power groove is also provided with teeth, a planetary gear is provided inside the power groove, the surface of the planetary gear is respectively meshed with the power groove and the rotating ring through the teeth, a limiting groove is provided on the outer surface of the positioning shaft, a slider is slidably connected inside the limiting groove, a connecting and fixing rod is fixedly connected to the outer surface of the slider, an end of the connecting and fixing rod away from the slider is fixedly connected to a tripod, a first threaded rod is rotatably connected inside the adjusting groove, the surface of the first threaded rod is threadedly connected to the inner surface of the top cover, a first motor is fixedly connected to the top of the support rod, and the output end of the first motor rotates through the top of the support rod and extends to the inside of the adjusting groove and is fixedly connected to the top of the first threaded rod.

[0010] The present invention is further configured as follows: a side of the tripod close to the planetary gear is rotationally connected to the surface of the planetary gear, and the planetary gear is rotationally connected to the bottom of the tripod via a shaft.

[0011] The present invention is further configured such that: a disturbance rod is fixedly connected to the outer surface of the rotating ring.

[0012] The present invention is further configured as follows: the interior of the support plate is slidably connected to an extension rod extending to the exterior of the support plate, and one side of the extension rod is fixedly connected to a scraper.

[0013] The present invention is further configured as follows: the internal rotation of the rotating main shaft is connected to a power shaft extending to the outside of the rotating main shaft, the interior of the rotating main shaft is provided with a transmission groove connected to the interior of the support plate, the bottom end of the power shaft is fixedly connected to a second bevel gear, the internal rotation of the support plate is connected to a second threaded rod, the surface of the second threaded rod is connected to the internal thread of the extension rod, the outer surface of the second threaded rod is fixedly connected to the first bevel gear, the surface of the first bevel gear is meshingly connected to the surface of the second bevel gear, the outer surface of the pressure plate is provided with a groove, and the scraper is arranged inside the groove.

[0014] The present invention is further configured as follows: the flushing assembly includes a water tank, the bottom of the water tank is fixedly connected to the top of the top cover, the top of the top cover is fixedly connected to a water pump, the water pump is connected to the interior of the water tank through a pipeline, the output end of the water pump is fixedly connected to a first connecting pipe, the interior of the top cover is fixedly connected to a second connecting pipe extending to the interior of the mixing barrel, and one end of the first connecting pipe close to the second connecting pipe is fixedly connected to the interior of the second connecting pipe.

[0015] The present invention is further configured as follows: the first connecting pipe is connected to the interior of the second connecting pipe, and a nozzle is provided at the bottom end of the second connecting pipe.

[0016] A process for preparing a cefditoren pivoxil mother core comprises the following specific steps:

[0017] Step 1: After the staff puts the acylase into the mixing barrel, the purified water is injected into the mixing barrel to clean the enzyme for standby use. After the pH value of the pre-enzymatic hydrolysis liquid is adjusted to meet the production process requirements, it is pumped into the mixing barrel with a pump. The staff starts the second motor, and the second motor drives the driven gear and the rotating main shaft to rotate through the driving gear. The rotating main shaft drives the support plate to rotate. At the same time, the staff starts the hydraulic press, and the hydraulic press drives the pressing plate to move up and down, and the pressing plate squeezes the material inside the mixing barrel during the rotation process. During the extrusion process, the material is continuously filtered and squeezed through the filter holes, effectively and evenly mixing the dispersed materials in the stock solution, so that the materials can be mixed more smoothly;

[0018] Step 2: The pressing plate is rotated to make the power slot drive the planetary gear to rotate, and the planetary gear drives the rotating ring to rotate, so that the rotating ring and the pressing plate rotate in opposite directions, so that the pressing plate drives the rotating ring to rotate in the opposite direction and move up and down during the process of moving up and down and rotating, so that the disturbance rod disturbs the material for the second time;

[0019] Step 3: When the inner wall of the mixing barrel needs to be cleaned, the power shaft is rotated by the staff, and the power shaft drives the second threaded rod to rotate through the meshing connection between the first bevel gear and the second bevel gear, so that the second threaded rod drives the extension rod to move, and the scraper can be close to the inner wall of the mixing barrel, and the staff starts the second motor, so that the second motor drives the driven gear and the rotating main shaft to rotate through the driving gear, and the rotating main shaft drives the support plate to rotate, and the scraper scrapes and cleans the inner wall of the mixing barrel;

[0020] Step 4: The staff starts the water pump, which transfers the cleaning solution in the water tank to the nozzle through the first connecting pipe and the second connecting pipe, and makes the nozzle spray the solution to clean the scraper.

[0021] The advantages of the present invention are:

[0022] 1. A preparation device and method for a cefditoren pivoxil mother core of the present invention drives a pressing plate to move up and down by a hydraulic press, and the pressing plate can extrude the material inside a mixing barrel during rotation. During the extrusion process, the material can be continuously filtered and extruded through filter holes, effectively and evenly mixing the dispersed materials in the stock solution, so that the materials can be mixed more smoothly.

[0023] 2. The present invention provides a preparation device and method for a cefditoren pivoxil mother core. The rotating ring rotates in opposite directions to the pressing plate, so that the pressing plate can drive the rotating ring to rotate in the opposite direction and move up and down during the process of moving up and down and rotating, so that the disturbance rod can perform a secondary disturbance on the material, and the mixing and stirring of the material is smoother, and the mixing of the material is more uniform.

[0024] 3. The present invention provides a device and method for preparing a cefditoren pivoxil core. The main shaft is rotated to drive the support plate to rotate, and the scraper can scrape and clean the inner wall of the mixing barrel, which can reduce the long-term adhesion of materials to the inner wall of the mixing barrel, causing the material to deteriorate and affect the material processing, and make it more convenient for the staff to clean the inner wall of the mixing barrel.

[0025] 4. The present invention provides a device and method for preparing a cefditoren pivoxil mother core. The cleaning solution inside the water tank is transferred to the nozzle through the first connecting pipe and the second connecting pipe by a water pump, and the nozzle sprays the solution to clean the scraper to a certain extent, so that the staff can clean the device more conveniently. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a structural schematic diagram of a device for preparing a cefditoren pivoxil mother core of the present invention;

[0027] Figure 2 It is a schematic diagram of the structure of the mixing barrel of the present invention;

[0028] Figure 3 It is a structural schematic diagram of the support rod of the present invention;

[0029] Figure 4 It is a schematic diagram of the structure of the dynamic disturbance mixing component of the present invention;

[0030] Figure 5 It is a structural schematic diagram of the support plate of the present invention;

[0031] Figure 6 It is a structural schematic diagram of the pressing plate of the present invention;

[0032] Figure 7 It is a schematic diagram of the structure of the flushing component of the present invention.

[0033] In the figure: 1, base; 2, support rod; 3, mixing barrel; 4, adjustment groove; 5, top cover; 6, power mixing assembly; 7, power disturbance mixing assembly; 8, flushing assembly; 9, first threaded rod; 10, first motor; 11, groove; 12, second threaded rod; 13, extension rod; 14, scraper; 15, first bevel gear; 16, second bevel gear; 17, transmission groove; 18, power shaft; 19, tripod; 20, connecting fixing rod;

[0034] 601, rotating main shaft; 602, driven gear; 603, driving gear; 604, second motor; 605, support plate; 606, hydraulic press; 607, pressing plate; 608, filter hole;

[0035] 701, positioning shaft; 702, rotating ring; 703, disturbance rod; 704, power slot; 705, planetary gear; 706, limit slot; 707, slider;

[0036] 801, water tank; 802, water pump; 803, first connecting pipe; 804, second connecting pipe. DETAILED DESCRIPTION

[0037] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application may be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0038] It should be noted that, unless otherwise specified, all technical and scientific terms used in this application have the same meanings as commonly understood by ordinary technicians in the technical field to which this application belongs.

[0039] In the present invention, unless otherwise specified, the directions used, such as "up" and "down", usually refer to the directions shown in the drawings, or to the vertical, perpendicular or gravity directions; similarly, for ease of understanding and description, "left" and "right" usually refer to the left and right shown in the drawings; "inside" and "outside" refer to the inside and outside relative to the outline of each component itself, but the above-mentioned directions are not used to limit the present invention.

[0040] See also Figure 1-7 The present invention provides the following technical solutions: a preparation device for a cefditoren pivoxil mother core, comprising a base 1, a support rod 2 is fixedly connected to the top of the base 1, a mixing barrel 3 is arranged on the top of the base 1, an adjusting groove 4 is opened on the side of the support rod 2 close to the mixing barrel 3, a top cover 5 extending to the outside of the adjusting groove 4 is slidably connected inside the adjusting groove 4, the mixing barrel 3 can be closed by the top cover 5, so that the mixing barrel 3 can mix and stir the materials more smoothly, a power mixing component 6 is arranged on the top cover 5, a flushing component 8 is arranged on the top of the top cover 5, a first threaded rod 9 is rotatably connected inside the adjusting groove 4, the surface of the first threaded rod 9 is threadedly connected to the inside of the top cover 5, a first motor 10 is fixedly connected to the top of the support rod 2, the output end of the first motor 10 rotates through the top of the support rod 2 and extends to the inside of the adjusting groove 4 and is fixedly connected to the top of the first threaded rod 9, and the first motor 10 drives the first threaded rod 9 to rotate so that the top cover 5 can move up and down.

[0041] Specifically, the power mixing assembly 6 includes a rotating main shaft 601, the surface of the rotating main shaft 601 is rotatably connected to the inside of the top cover 5, the outer surface of the rotating main shaft 601 is fixedly connected to a driven gear 602, the top of the top cover 5 is fixedly connected to a second motor 604, the second motor 604 is an existing structure, and no further details are given here, the output end of the second motor 604 is fixedly connected to a driving gear 603, the surface of the driving gear 603 is meshingly connected to the surface of the driven gear 602, the bottom end of the rotating main shaft 601 is fixedly connected to a support plate 605, the bottom of the support plate 605 is fixedly connected to a hydraulic press 606, the hydraulic press 606 is an existing structure, and no further details are given here, the output end of the hydraulic press 606 is fixedly connected to a hydraulic press Plate 607, a filter hole 608 extending to the outside of the pressing plate 607 is opened inside the pressing plate 607, and the second motor 604 is started by the staff. The second motor 604 drives the driven gear 602 and the rotating main shaft 601 to rotate through the driving gear 603, and the rotating main shaft 601 drives the supporting plate 605 to rotate. At the same time, the hydraulic press 606 is started by the staff, and the hydraulic press 606 drives the pressing plate 607 to move up and down, and the pressing plate 607 can squeeze the material inside the mixing barrel 3 during the rotation process. During the extrusion process, the material can be continuously filtered and squeezed through the filter hole 608, so that the dispersed materials in the stock solution are effectively and evenly mixed, so that the materials can be mixed more smoothly.

[0042] Furthermore, a power disturbance mixing component 7 is provided at the bottom of the support plate 605, and the power disturbance mixing component 7 includes a positioning shaft 701, the top of the positioning shaft 701 is fixedly connected to the bottom of the support plate 605, and the internal rotation of the pressure plate 607 is connected to a rotating ring 702, and the rotating ring 702 is movably sleeved on the positioning shaft 701, and the rotating ring 702 can rotate and move on the positioning shaft 701, and the pressure plate 607 is provided with a power groove 704 inside, and the rotating ring 702 is arranged inside the power groove 704, and the outer surface of the rotating ring 702 is provided with teeth, and the inner surface of the power groove 704 is also provided with teeth, and the power groove 704 is provided with a planetary gear 705, and the surface of the planetary gear 705 The surfaces are meshed with the power slot 704 and the rotating ring 702 through teeth respectively, a limiting slot 706 is provided on the outer surface of the positioning shaft 701, and a slider 707 is slidably connected inside the limiting slot 706, and the outer surface of the slider 707 is fixedly connected with a connecting and fixing rod 20, and the end of the connecting and fixing rod 20 away from the slider 707 is fixedly connected with a tripod 19, and the side of the tripod 19 close to the planetary gear 705 is rotatably connected to the surface of the planetary gear 705, and the planetary gear 705 is rotatably connected to the bottom of the tripod 19 through an axis, and the position of the planetary gear 705 is positioned and limited through the mutual cooperation of the tripod 19, the connecting and fixing rod 20, the limiting slot 706, the slider 707 and the positioning shaft 701.

[0043] Furthermore, a disturbance rod 703 is fixedly connected to the outer surface of the rotating ring 702, and the material can be disturbed by the disturbance rod 703.

[0044] By rotating the pressing plate 607, the power slot 704 drives the planetary gear 705 to rotate, and the planetary gear 705 drives the rotating ring 702 to rotate, so that the rotating ring 702 and the pressing plate 607 rotate in opposite directions, so that the pressing plate 607 can drive the rotating ring 702 to rotate in the opposite direction and move up and down during the process of moving up and down and rotating, so that the disturbance rod 703 can perform secondary disturbance on the material, and the mixing and stirring of the material can be smoother, and the mixing of the material can be made more uniform.

[0045] Furthermore, the support plate 605 is internally slidably connected to an extension rod 13 extending to the outside of the support plate 605, and a scraper 14 is fixedly connected to one side of the extension rod 13, through which the inner wall of the mixing barrel 3 can be scraped and cleaned, the rotating main shaft 601 is internally rotatably connected to a power shaft 18 extending to the outside of the rotating main shaft 601, and the rotating main shaft 601 is provided with a transmission groove 17 connected to the inside of the support plate 605, and the bottom end of the power shaft 18 is fixedly connected to a second bevel gear 16, the support plate 605 is internally rotatably connected to a second threaded rod 12, the surface of the second threaded rod 12 is connected to the internal thread of the extension rod 13, and the outer surface of the second threaded rod 12 is fixedly connected to a first bevel gear 15, and the surface of the first bevel gear 15 is meshingly connected to the surface of the second bevel gear 16, and the outer surface of the pressing plate 607 is provided with a groove 11, and the scraper 14 is arranged inside the groove 11, and the scraper 14 can move to a certain extent inside the groove 11.

[0046] When the inner wall of the mixing barrel 3 needs to be cleaned, the staff rotates the power shaft 18, and the power shaft 18 drives the second threaded rod 12 to rotate through the meshing connection between the first bevel gear 15 and the second bevel gear 16, so that the second threaded rod 12 drives the extension rod 13 to move, and the scraper 14 can be close to the inner wall of the mixing barrel 3, and the staff starts the second motor 604, so that the second motor 604 drives the driven gear 602 and the rotating main shaft 601 to rotate through the driving gear 603, and the rotating main shaft 601 drives the support plate 605 to rotate, and the scraper 14 can scrape and clean the inner wall of the mixing barrel 3, which to a certain extent reduces the long-term adhesion of materials to the inner wall of the mixing barrel 3, causing the material to deteriorate and affect the material processing, and allows the staff to clean the inner wall of the mixing barrel 3 more conveniently.

[0047] The flushing assembly 8 includes a water tank 801, the bottom of which is fixedly connected to the top of the top cover 5, a water pump 802 is fixedly connected to the top of the top cover 5, the water pump 802 is connected to the interior of the water tank 801 through a pipeline, the output end of the water pump 802 is fixedly connected to a first connecting pipe 803, the interior of the top cover 5 is fixedly connected to a second connecting pipe 804 extending to the interior of the mixing barrel 3, one end of the first connecting pipe 803 close to the second connecting pipe 804 is fixedly connected to the interior of the second connecting pipe 804, the first connecting pipe 803 is connected to the interior of the second connecting pipe 804, and a nozzle is provided at the bottom end of the second connecting pipe 804.

[0048] The staff starts the water pump 802, which transfers the cleaning solution in the water tank 801 to the nozzle through the first connecting pipe 803 and the second connecting pipe 804, and makes the nozzle spray the solution to clean the scraper 14 to a certain extent, so that the staff can clean the device more conveniently.

[0049] A process for preparing a cefditoren pivoxil mother core comprises the following specific steps:

[0050] Step 1: After the staff puts the acylase into the mixing barrel 3, purified water is injected into the mixing barrel 3 to clean the enzyme for standby use. After the pH value of the pre-enzymatic hydrolysis liquid is adjusted to meet the production process requirements, it is pumped into the mixing barrel 3 with a pump, and the staff starts the second motor 604, and the second motor 604 drives the driven gear 602 and the rotating main shaft 601 to rotate through the driving gear 603, and the rotating main shaft 601 drives the support plate 605 to rotate. At the same time, the staff starts the hydraulic press 606, and the hydraulic press 606 drives the pressing plate 607 to move up and down, and the pressing plate 607 can squeeze the material inside the mixing barrel 3 during the rotation process. During the extrusion process, the material can be continuously filtered and squeezed through the filter hole 608, effectively and evenly mixing the dispersed materials in the stock solution, so that the materials can be mixed more smoothly;

[0051] Step 2: The pressing plate 607 is rotated to make the power slot 704 drive the planetary gear 705 to rotate, and the planetary gear 705 drives the rotating ring 702 to rotate, so that the rotating ring 702 and the pressing plate 607 rotate in opposite directions, so that the pressing plate 607 can drive the rotating ring 702 to rotate in the opposite direction and move up and down during the process of moving up and down and rotating, so that the disturbance rod 703 can perform secondary disturbance on the material;

[0052] Step 3: When the inner wall of the mixing barrel 3 needs to be cleaned, the power shaft 18 is rotated by the staff, and the power shaft 18 drives the second threaded rod 12 to rotate through the meshing connection between the first bevel gear 15 and the second bevel gear 16, so that the second threaded rod 12 drives the extension rod 13 to move, and the scraper 14 can be close to the inner wall of the mixing barrel 3, and the staff starts the second motor 604, so that the second motor 604 drives the driven gear 602 and the rotating main shaft 601 to rotate through the driving gear 603, and the rotating main shaft 601 drives the support plate 605 to rotate, so that the scraper 14 can scrape and clean the inner wall of the mixing barrel 3;

[0053] Step 4: The water pump 802 is started by a staff member, and the water pump 802 transfers the cleaning solution in the water tank 801 to the nozzle through the first connecting pipe 803 and the second connecting pipe 804, and the nozzle sprays the solution to clean the scraper 14.

[0054] Obviously, the above-described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0055] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0056] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the numbers used in this way can be interchanged where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein.

[0057] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A device for preparing a cefditoren pivoxil core, comprising a base (1), characterized in that: The top of the base (1) is fixedly connected to a support rod (2), a mixing barrel (3) is arranged on the top of the base (1), an adjustment groove (4) is provided on a side of the support rod (2) close to the mixing barrel (3), the inside of the adjustment groove (4) is slidably connected to a top cover (5) extending to the outside of the adjustment groove (4), a power mixing assembly (6) is arranged on the top cover (5), and a flushing assembly (8) is arranged on the top of the top cover (5); The power mixing assembly (6) comprises a rotating main shaft (601), the surface of the rotating main shaft (601) is rotatably connected to the inside of the top cover (5), the outer surface of the rotating main shaft (601) is fixedly connected to a driven gear (602), the top of the top cover (5) is fixedly connected to a second motor (604), the output end of the second motor (604) is fixedly connected to a driving gear (603), the surface of the driving gear (603) is meshingly connected to the surface of the driven gear (602), the bottom end of the rotating main shaft (601) is fixedly connected to a support plate (605), the bottom of the support plate (605) is fixedly connected to a hydraulic press (606), the output end of the hydraulic press (606) is fixedly connected to a pressing plate (607), and a filter hole (608) extending to the outside of the pressing plate (607) is opened inside the pressing plate (607); The bottom of the support plate (605) is provided with a power disturbance mixing component (7), which comprises a positioning shaft (701), the top end of the positioning shaft (701) is fixedly connected to the bottom of the support plate (605), the interior of the pressure plate (607) is rotatably connected to a rotating ring (702), the rotating ring (702) is movably sleeved on the positioning shaft (701), the interior of the pressure plate (607) is provided with a power groove (704), the rotating ring (702) is arranged inside the power groove (704), the outer surface of the rotating ring (702) is provided with teeth, the inner surface of the power groove (704) is also provided with teeth, the interior of the power groove (704) is provided with a planetary gear (705), the surface of the planetary gear (705) is respectively connected to the power through the teeth The groove (704) is meshedly connected with the rotating ring (702); a limiting groove (706) is provided on the outer surface of the positioning shaft (701); a slider (707) is slidably connected inside the limiting groove (706); a connecting and fixing rod (20) is fixedly connected to the outer surface of the slider (707); an end of the connecting and fixing rod (20) away from the slider (707) is fixedly connected to a tripod (19); a first threaded rod (9) is rotatably connected inside the adjustment groove (4); a surface of the first threaded rod (9) is threadably connected to the inside of the top cover (5); a first motor (10) is fixedly connected to the top of the support rod (2); an output end of the first motor (10) rotates through the top of the support rod (2) and extends to the inside of the adjustment groove (4) and is fixedly connected to the top of the first threaded rod (9).

2. A device for preparing a cefditoren pivoxil mother nucleus according to claim 1, characterized in that: A side of the tripod (19) close to the planetary gear (705) is rotationally connected to the surface of the planetary gear (705), and the planetary gear (705) is rotationally connected to the bottom of the tripod (19) via a shaft.

3. A device for preparing a cefditoren pivoxil mother nucleus according to claim 2, characterized in that: A disturbance rod (703) is fixedly connected to the outer surface of the rotating ring (702).

4. A device for preparing a cefditoren pivoxil mother nucleus according to claim 3, characterized in that: An extension rod (13) extending to the outside of the support plate (605) is slidably connected to the inside of the support plate (605), and a scraper (14) is fixedly connected to one side of the extension rod (13).

5. A device for preparing a cefditoren pivoxil mother nucleus according to claim 4, characterized in that: The rotating main shaft (601) is internally rotatably connected to a power shaft (18) extending to the outside of the rotating main shaft (601); the rotating main shaft (601) is internally provided with a transmission groove (17) communicating with the inside of the support plate (605); the bottom end of the power shaft (18) is fixedly connected to a second bevel gear (16); the inside of the support plate (605) is internally rotatably connected to a second threaded rod (12); the surface of the second threaded rod (12) is threadedly connected to the inside of the extension rod (13); the outer surface of the second threaded rod (12) is fixedly connected to a first bevel gear (15); the surface of the first bevel gear (15) is meshingly connected to the surface of the second bevel gear (16); the outer surface of the pressure plate (607) is provided with a groove (11); and the scraper (14) is arranged inside the groove (11).

6. A device for preparing a cefditoren pivoxil mother nucleus according to claim 5, characterized in that: The flushing assembly (8) comprises a water tank (801), the bottom of the water tank (801) being fixedly connected to the top of the top cover (5), the top of the top cover (5) being fixedly connected to a water pump (802), the water pump (802) being connected to the interior of the water tank (801) via a pipeline, the output end of the water pump (802) being fixedly connected to a first connecting pipe (803), the interior of the top cover (5) being fixedly connected to a second connecting pipe (804) extending to the interior of the mixing barrel (3), and one end of the first connecting pipe (803) close to the second connecting pipe (804) being fixedly connected to the interior of the second connecting pipe (804).

7. A device for preparing a cefditoren pivoxil mother nucleus according to claim 6, characterized in that: The first connecting pipe (803) is connected to the interior of the second connecting pipe (804), and a nozzle is provided at the bottom end of the second connecting pipe (804).

8. A method for preparing a cefditoren pivoxil core, based on a device for preparing a cefditoren pivoxil core according to claim 7, characterized in that: The specific steps include: The first step: after the staff puts the acylase into the mixing barrel (3), purified water is injected into the mixing barrel (3) to clean the enzyme for standby use. After the cephalosporin C sodium salt concentrate is heated and the pH value is adjusted to meet the production process requirements, it is pumped into the mixing barrel (3) by a pump. The staff starts the second motor (604), and the second motor (604) drives the driven gear (602) and the rotating main shaft (601) to rotate through the driving gear (603). The rotating main shaft (601) drives the support plate (605) to rotate. At the same time, the staff starts the hydraulic press (606), and the hydraulic press (606) drives the pressing plate (607) to move up and down, and the pressing plate (607) squeezes the material inside the mixing barrel (3) during the rotation process. During the squeezing process, the material is continuously filtered and squeezed through the filter hole (608), effectively and evenly mixing the dispersed materials in the stock solution, so that the materials are mixed more smoothly; Step 2: The pressing plate (607) is rotated to make the power slot (704) drive the planetary gear (705) to rotate, and the planetary gear (705) drives the rotating ring (702) to rotate, so that the rotating ring (702) and the pressing plate (607) rotate in opposite directions, so that the pressing plate (607) drives the rotating ring (702) to rotate in the opposite direction and move up and down during the process of moving up and down and rotating, so that the disturbance rod (703) performs a secondary disturbance on the material; Step 3: When the inner wall of the mixing barrel (3) needs to be cleaned, the power shaft (18) is rotated by a staff member, and the power shaft (18) drives the second threaded rod (12) to rotate through the meshing connection between the first bevel gear (15) and the second bevel gear (16), so that the second threaded rod (12) drives the extension rod (13) to move, and the scraper (14) can be closely attached to the inner wall of the mixing barrel (3), and the staff member starts the second motor (604), so that the second motor (604) drives the driven gear (602) and the rotating main shaft (601) to rotate through the driving gear (603), and the rotating main shaft (601) drives the support plate (605) to rotate, and the scraper (14) scrapes and cleans the inner wall of the mixing barrel (3); Step 4: The water pump (802) is started by a staff member, and the water pump (802) transmits the cleaning solution in the water tank (801) to the nozzle through the first connecting pipe (803) and the second connecting pipe (804), and the nozzle sprays the solution to clean the scraper (14).

Images